Jonathon Nixon-Abell, Francesco S Ruggeri, Seema Qamar, Therese W Herling, Magdalena A Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S Fernandopulle, Tomas Sneideris, Joseph L Watson, Visakh V S Pillai, William Meadows, James W Henderson, Joseph E Chambers, Jane L Wagstaff, Sioned H Williams, Helena Coyle, Yuqian Lu, Shuyuan Zhang, Stefan J Marciniak, Stefan M V Freund, Emmanuel Derivery, Michael E Ward, Michele Vendruscolo, Tuomas P J Knowles, Peter St George-Hyslop
Phase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. The frequent juxtaposition of proteinaceous biomolecular condensates to cellular membranes raises the intriguing prospect that phase transitions in proteins and lipids could be co-regulated. Here we investigate this possibility in the ribonucleoprotein (RNP) granule-ANXA11-lysosome ensemble, where ANXA11 tethers RNP granule condensates to lysosomal membranes to enable their co-trafficking...
March 24, 2023: bioRxiv