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G P Senadheera, S Sri Ranganathan, G Patabendige, G H Fernando, D Gamage, R M Maneke, B M Fernandopulle
OBJECTIVES: Antibacterial resistance (ABR) is a public threat. Sri Lanka is a country with limited surveillance of ABR in the community. The WHO methodology was adapted to identify ABR in outpatient settings (nonhospitalised patients) and its link to consumption of antibiotics. METHODS: It was a cross-sectional descriptive community based study to collect ABR data from Out Patient Department (OPD) of two leading Teaching Hospitals in Colombo district. The indicator organism Escherichia coli (E...
2016: Ceylon Medical Journal
K Sanchayan, R Fernandopulle, A Amarasinghe, S N Thiyahiny, S Sri Ranganathan
OBJECTIVES: This study was designed to describe the safety profile of the single dose live attenuated Japanese encephalitis vaccine (LJEV) SA-14-14-2 given at the age of 9 months in the National Immunisation programme of Sri Lanka. METHODS: cohort event monitoring (CEM) was conducted in the Jaffna district during November 2012 to January 2015. A representative sample of 3041 infants who received the LJEV at the age of 9 months was followed up actively over telephone interviews on days 1, 3, 14, 30 and 45 for adverse events (AE)...
2016: Ceylon Medical Journal
Fathima Wardha Refai, Nayani P Madarasingha, Rohini Fernandopulle, Nadira Karunaweera
Leishmaniasis is caused by parasitic protozoa of the genus Leishmania. Cutaneous leishmaniasis (CL) is endemic in Sri Lanka with over 3000 cases during the last decade and numbers are increasing. Treatment options available in Sri Lanka for CL include intralesional/intramuscular sodium stibogluconate and cryotherapy. Eight cases of treatment failure with standard therapy are reported from the Dermatology Clinic, Teaching Hospital Anuradhapura. Therapeutic regimes aim for clinical healing, these patients responded poorly to anti-leishmanial therapy, indicating the need for close monitoring, explore alternative treatment options and to investigate for drug resistance in parasites...
July 2016: Tropical Parasitology
Barbara Rath, Jane F Gidudu, Helen Anyoti, Brigid Bollweg, Patrick Caubel, Yeoung-Hwang Chen, David Cornblath, Rohini Fernandopulle, Louis Fries, Jochem Galama, Neville Gibbs, Gualtiero Grilli, Patrick Grogan, Katharina Hartmann, Ulrich Heininger, Michael J Hudson, Hector S Izurieta, Indira Jevaji, Wiltshire M Johnson, James Jones, Brigitte Keller-Stanislawski, Jerome Klein, Katrin Kohl, Panagiotis Kokotis, Yulin Li, Thomas Linder, James Oleske, Georgina Richard, Tarek Shafshak, Michael Vajdy, Virginia Wong, James Sejvar
No abstract text is available yet for this article.
May 24, 2016: Vaccine
H Banneheke, R Fernandopulle, U Gunasekara, A Barua, N Fernando, R Wickremasinghe
Wet mount microscopy is the most commonly used diagnostic method for trichomoniasis in clinical diagnostic services all over the world including Sri Lanka due to its availability, simplicity and is relatively inexpensive. However, Trichomonas culture and PCR are the gold standard tests. Unfortunately, neither the culture nor PCR is available for the diagnosis of trichomoniasis in Sri Lanka. Thus, it is important to validate the wet mount microscopy as it is the only available diagnostic test and has not been validated to date in Sri Lanka...
June 2015: Tropical Biomedicine
Isurujith K Liyanage, Mitrakrishnan R Navinan, A C A Pathirana, H R I S Herath, Jevon Yudhishdran, Nilesh Fernandopulle, Aruna Kulatunga
Methyl Ethyl Ketone Peroxide (MEKP) is a highly toxic clear liquid used as a solvent. It is a strong oxidizing agent and a corrosive. Acute and chronic toxicity can occur as an occupational hazard. Ingestion is associated with corrosive burns leading to stricture formation, inhalational pneumonitis, acidosis, liver failure and renal failure. In this paper we present a case of a young patient who intentionally ingested MEKP. The patient developed multiple complications including proximal intestinal obstruction, acidosis and acute kidney injury...
2015: Journal of Occupational Medicine and Toxicology
Corey L Compton, Michael S Fernandopulle, Rohith T Nagari, Jason K Sello
UNLABELLED: Pupylation is a posttranslational modification peculiar to actinobacteria wherein proteins are covalently modified with a small protein called the prokaryotic ubiquitin-like protein (Pup). Like ubiquitination in eukaryotes, this phenomenon has been associated with proteasome-mediated protein degradation in mycobacteria. Here, we report studies of pupylation in a streptomycete that is phylogentically related to mycobacteria. We constructed mutants of Streptomyces coelicolor lacking PafA (Pup ligase), the proteasome, and the Pup-proteasome system...
September 2015: Journal of Bacteriology
Crispin Corte, Nilesh Fernandopulle, Ana Maria Catuneanu, Daniel Burger, Monica Cesarini, Lydia White, Satish Keshav, Simon Travis
BACKGROUND: The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) accounts for 86% of the variance between observers in the overall assessment of endoscopic severity, but has not been correlated with outcomes. METHODS: Consecutive cases of acute severe colitis (ASC) defined by Truelove and Witts (TW) criteria were retrospectively evaluated. Demographic details, number of TW criteria, prior medical therapy, UCEIS and inpatient medical therapy were recorded...
May 2015: Journal of Crohn's & Colitis
Michael Pavlides, Ashley Barnabas, Nilesh Fernandopulle, Adam A Bailey, Jane Collier, Jane Phillips-Hughes, Anthony Ellis, Roger Chapman, Barbara Braden
AIM: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography (ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation. METHODS: In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscopy and radiology reporting databases were analysed for use of precut sphincterotomy, biliary access rate, repeat ERCP rate and complications. Patients with initially failed precut sphincterotomy were identified...
September 28, 2014: World Journal of Gastroenterology: WJG
Naohisa Yoshida, Nilesh Fernandopulle, Yutaka Inada, Yuji Naito, Yoshito Itoh
Colonoscopic examination is considered an effective examination for the detection of colorectal cancers. Additionally, early colorectal cancers can be resected using endoscopic techniques such as endoscopic mucosal resection and endoscopic submucosal dissection. However, those examinations and treatments need special techniques. Various training methods are practiced to acquire such endoscopic techniques throughout the world. In clinical cases, magnetic positioning devices help endoscopic insertion by less experienced endoscopists...
September 2014: Digestive Diseases and Sciences
A Kasturiratne, M N Mufeena, K C Mettananda, N Fernandopulle, S Rajindrajith, P R Waraketiya, S K Weerasinghe, A Ranaweera, S J Hewavisenthi, A P de Silva, H J de Silva
The aim of this report is to provide details of the methodology and results of the Sri Lankan component of the Asia-Pacific Crohn's and Colitis Epidemiology Study. Fourteen state and private hospitals with specialist services in the Gampaha and Colombo districts were kept under surveillance over a 12 month period to recruit patients with newly diagnosed Inflammatory Bowel Disease (IBD) who were permanent residents of the Gampaha district. Thirty five cases (ulcerative colitis-21, Crohn's disease-13, IBD-undetermined-1) were detected, giving a crude annual IBD incidence of 1...
March 2014: Ceylon Medical Journal
Rushika Fernandopulle
In this first installment of a new quarterly column on lessons learned from the cutting edge of care innovation, we discuss the imperative for and insights on how to move health care away from its current transactional focus and towards a more human-centric model.
April 2014: Journal of Ambulatory Care Management
Naohisa Yoshida, Yuji Naito, Ryouhei Hirose, Kiyoshi Ogiso, Yutaka Inada, Nilesh Fernandopulle, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Naoki Wakabayashi, Akio Yanagisawa, Yoshito Itoh
PURPOSE: The detailed efficacy of intraluminal L-menthol for preventing colonic spasm is not known. The aim of this study was to evaluate the effectiveness of L-menthol in preventing colonic spasm during colonoscopy. METHODS: We analyzed 65 patients (mean age: 71.7 years; 49 men and 16 women) who were administered 0.8% L-menthol (MINCLEA, Nihon Seiyaku, Tokyo, Japan) intraluminally for severe colonic spasm during colonoscopic examination at Kyoto Prefectural University of Medicine between February 2012 and May 2013...
May 2014: International Journal of Colorectal Disease
H Banneheke, R Fernandopulle, S Prathanapan, G de Silva, N Fernando, R Wickremasinghe
As a majority of the trichomoniasis patients are asymptomatic, laboratory tests are crucial in case detection. The usefulness of culture and immunochromatographic technique (ICT) compared to microscopy for detection of trichomoniasis in Sri Lanka was assessed. Females (16-45 years) from Colombo district were screened for Trichomonas vaginalis using three laboratory tests namely, microscopy of wet smear, Trichomonas liquid culture and ICT (OSOM® trichomonas rapid test). Trichomoniasis by at least one test being positive was 4...
September 2013: Ceylon Medical Journal
Sudul Mananjala Senanayake, Anthony Nilesh Ranjeev Fernandopulle, Madunil Anuk Niriella, Nethini Thilanga Wijesinghe, Amanda Ranaweera, Mohammadu Nisar Mufeena, Arunasalam Pathmeswaran, Nawarathnelage Meththananda Nawarathne, Arjuna Priyadarsin de Silva, Hithanadura Janaka de Silva
BACKGROUND: Inflammatory bowel disease, especially ulcerative colitis, is increasing in many "non-Western" countries, including Sri Lanka. The aim was to evaluate long-term outcomes of ulcerative colitis in a Sri Lankan population. METHODS: A retrospective cohort study was conducted at the gastroenterology clinics of the Colombo North Teaching Hospital, Ragama and the National Hospital of Sri Lanka, Colombo; the two major referral centers for ulcerative colitis...
2013: Clinical and Experimental Gastroenterology
Jennifer Fu, Samantha Kwok, Leah Sinai, Omar Abdel-Razek, Janet Babula, Dennis Chen, Emma Farago, Nigel Fernandopulle, Sean Leith, Melissa Loyzer, Catherine Lu, Niyati Malkani, Nicole Morris, Mandi Schmidt, Randa Stringer, Heather Whitehead, Matthew R Ban, Joseph B Dubé, Adam McIntyre, Christopher T Johansen, Henian Cao, Jian Wang, Robert A Hegele
BACKGROUND: Next-generation sequencing (NGS) is nearing routine clinical application, especially for diagnosis of rare monogenic cardiovascular diseases. But NGS uncovers so much variation in an individual genome that filtering steps are required to streamline data management. The first step is to determine whether a potential disease-causing variant has been observed previously in affected patients. METHODS: To facilitate this step for lipid disorders, we developed the Western Database of Lipid Variants (WDLV) of 2776 variants in 24 genes that cause monogenic dyslipoproteinemias, including conditions characterized primarily by either high or low low-density lipoprotein cholesterol, high or low high-density lipoprotein cholesterol, high triglyceride, and some miscellaneous disorders...
August 2013: Canadian Journal of Cardiology
Jan Bonhoeffer, Egeruan B Imoukhuede, Grace Aldrovandi, Novilia S Bachtiar, Eng-Soon Chan, Soju Chang, Robert T Chen, Rohini Fernandopulle, Karen L Goldenthal, James D Heffelfinger, Shah Hossain, Indira Jevaji, Ali Khamesipour, Sonali Kochhar, Mamodikoe Makhene, Elissa Malkin, David Nalin, Rebecca Prevots, Ranjan Ramasamy, Sarah Sellers, Johan Vekemans, Kenneth B Walker, Pam Wilson, Virginia Wong, Khalequz Zaman, Ulrich Heininger
This document is intended as a guide to the protocol development for trials of prophylactic vaccines. The template may serve phases I-IV clinical trials protocol development to include safety relevant information as required by the regulatory authorities and as deemed useful by the investigators. This document may also be helpful for future site strengthening efforts.
November 12, 2013: Vaccine
Rushika Fernandopulle
While most approaches to improving primary care delivery involve making incremental improvements to existing practices, for the past decade we have been engaged in a different approach-to build new practices from the ground up to demonstrate a vision of what is possible. Our Iora model of care combines a new payment model which does away with all fee for service billing, a new delivery model focused on robust team-based population management, and a new IT system to drive this very different care. We have demonstrated in several pilots improved experience, outcomes, and lower total cost of care...
April 2013: Journal of Ambulatory Care Management
Ping Cheng, Derrick L J Clive, Shimal Fernandopulle, Zhenhua Chen
The first synthesis of marinopyrrole B, which is highly active against methicillin-resistant Staphylococcus aureus, is described. The route involved constructing a pyrrole ring on the nitrogen of a 3-bromo-4,5-dichloropyrrole by N-alkylation with a special Michael acceptor having an allylic leaving group; the second pyrrole ring was then formed by a Paal-Knorr reaction.
January 21, 2013: Chemical Communications: Chem Comm
S M D K Ganga Senarathna, Shalini S Ranganathan, Nick Buckley, S S S B D Preethi Soysa, B M Rohini Fernandopulle
OBJECTIVES: Acute paracetamol poisoning is an emerging problem in Sri Lanka. Management guidelines recommend ingested dose and serum paracetamol concentrations to assess the risk. Our aim was to determine the usefulness of the patient's history of an ingested dose of >150 mg/kg and paracetamol concentration obtained by a simple colorimetric method to assess risk in patients with acute paracetamol poisoning. MATERIALS AND METHODS: Serum paracetamol concentrations were determined in 100 patients with a history of paracetamol overdose using High Performance Liquid Chromatography (HPLC); (reference method)...
July 2012: Indian Journal of Pharmacology
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