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Michael S Fernandopulle, Ryan Prestil, Christopher Grunseich, Chao Wang, Li Gan, Michael E Ward
Accurate modeling of human neuronal cell biology has been a long-standing challenge. However, methods to differentiate human induced pluripotent stem cells (iPSCs) to neurons have recently provided experimentally tractable cell models. Numerous methods that use small molecules to direct iPSCs into neuronal lineages have arisen in recent years. Unfortunately, these methods entail numerous challenges, including poor efficiency, variable cell type heterogeneity, and lengthy, expensive differentiation procedures...
June 2018: Current Protocols in Cell Biology
Adam L Beckman, Sanchay Gupta
No abstract text is available yet for this article.
June 2018: Healthcare
Nigel Fernandopulle, Luc Mertens, Michelle Klingel, David Manson, Felix Ratjen
Transthoracic contrast echocardiography (TTCE) has high sensitivity but low specificity in screening for pulmonary arteriovenous malformations (pAVMs) in children with hereditary hemorrhagic telangiectasia (HHT). Here we describe characteristics of TTCE that might be used to reduce the need for confirmatory computed tomography scans in children with HHT.
April 2018: Journal of Pediatrics
Wardha F Refai, Nayani P Madarasingha, Buthsiri Sumanasena, Sudath Weerasingha, Amala De Silva, Rohini Fernandopulle, Abhay R Satoskar, Nadira D Karunaweera
Leishmania donovani causes cutaneous leishmaniasis (CL) in Sri Lanka. Standard treatment is multiple, painful doses of intralesional sodium stibogluconate (IL-SSG). Treatment failures are increasingly reported, hence the need to investigate alternatives. Efficacy, safety, and cost-effectiveness of thermotherapy were assessed for the first time for L . donovani CL. A single blinded noninferiority randomized controlled trial was conducted on new laboratory-confirmed CL patients with single lesions ( N = 213)...
October 2017: American Journal of Tropical Medicine and Hygiene
Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, Suranjith L Seneviratne, Ushagowry Saravanamuttu, Preethi Udagama, Melanie Hart, Peter Kelleher, Upul Senerath, Rohini Fernandopulle, Lilani P Weerasekera, Lalith S Wijayaratne
BACKGROUND: The standard dose of rituximab used in rheumatoid arthritis (RA) is 1000 mg but recent studies have shown that low dose (500 mg) is also effective. Efficacy of low dose rituximab in rheumatoid arthritis (RA) refractory to first-line non-biologic Disease Modifying Anti Rheumatic Drugs (DMARDs), compared to leflunomide is unknown. In a tertiary care referral setting, we conducted a randomized, double blind controlled clinical trial comparing the efficacy and safety of low-dose rituximab-methotrexate combination with leflunomide-methotrexate combination...
July 19, 2017: BMC Musculoskeletal Disorders
Ilankoon Imps, Goonewardena Cse, Fernandopulle Rc, Perera Ppr
No abstract text is available yet for this article.
February 2017: Iranian Journal of Public Health
Santosh Vijaykumar, Rianne Wally Meurzec, Karthikayen Jayasundar, Claudia Pagliari, Yohan Fernandopulle
In 2016, Singapore grappled with one of the largest Zika outbreaks in Southeast Asia. This study examines the use of Facebook for Zika-related outreach by the Ministry of Health (MOH) and the National Environmental Agency (NEA) from March 1, 2015, to September 1, 2016, and public response to this effort. Despite nearly equivalent outreach, MOH's Facebook posts received more likes (µ = 3.49) and shares (µ = 30.11), whereas NEA's posts received more comments (µ = 4.55), with NEA posting mostly on prevention (N = 30) and MOH on situational updates (N = 24)...
November 1, 2017: Journal of the American Medical Informatics Association: JAMIA
G P Senadheera, Shalini Sri Ranganathan, N S Gunawardane, G H Fernando, B M Fernandopulle
No abstract text is available yet for this article.
March 31, 2017: Ceylon Medical Journal
K Sanchayan, R Fernandopulle, A Amarasinghe, S N Thiyahiny, S Sri Ranganathan
Objectives: This study was designed to report incidence and characteristics of selected adverse events following immunisation which have consistent causal association (AEFIc) with Measles-Mumps-Rubella (MMR) vaccination given at the age of one year in the National Immunisation Programme of Sri Lanka. Methods: The data presented here were obtained from a cohort event monitoring study. It was carried out in the Jaffna Regional Directorate of Health Services area from November 2012 to December 2014...
March 31, 2017: Ceylon Medical Journal
Shanelle Fernandopulle, Meredith Perry, Donald Manlapaz, Prasath Jayakaran
OBJECTIVE: The aim of this study was to evaluate the effects of land-based generic physical activity interventions on pain, physical function, and physical performance in individuals with hip/knee osteoarthritis, when compared with a control group that received no intervention, minimal intervention, or usual care. METHODS: A systematic search for randomized controlled trials on 11 electronic databases (from their inception up until April 30, 2016) identified 27 relevant articles...
November 2017: American Journal of Physical Medicine & Rehabilitation
Rushika Fernandopulle
No abstract text is available yet for this article.
April 2017: Journal of Ambulatory Care Management
N D S Goonawardhana, G S K W Jayasekara, V Elanahai, P V Udagama, N D Fernandopulle
Allele frequencies and forensically important parameters of ten autosomal miniSTR loci, D1S1677, D2S1776, D10S1248, D11S4463, D12SATA, D14S1434, D17S974, D18S853, D20S482, and D22S1045, were obtained for 278 unrelated adults from the Sri Lankan population. The combined power of discrimination and probability of exclusion was found to be 0.999999999621539 and 0.9979620, respectively. No significant deviations from Hardy-Weinberg equilibrium were observed except for D20S482 which conformed to HW expectations only after the application of a Bonferroni correction...
July 2017: International Journal of Legal Medicine
G P Senadheera, S Sri Ranganathan, G Patabendige, G H Fernando, D Gamage, R M Maneke, B M Fernandopulle
OBJECTIVES: Antibacterial resistance (ABR) is a public threat. Sri Lanka is a country with limited surveillance of ABR in the community. The WHO methodology was adapted to identify ABR in outpatient settings (nonhospitalised patients) and its link to consumption of antibiotics. METHODS: It was a cross-sectional descriptive community based study to collect ABR data from Out Patient Department (OPD) of two leading Teaching Hospitals in Colombo district. The indicator organism Escherichia coli (E...
2016: Ceylon Medical Journal
K Sanchayan, R Fernandopulle, A Amarasinghe, S N Thiyahiny, S Sri Ranganathan
OBJECTIVES: This study was designed to describe the safety profile of the single dose live attenuated Japanese encephalitis vaccine (LJEV) SA-14-14-2 given at the age of 9 months in the National Immunisation programme of Sri Lanka. METHODS: cohort event monitoring (CEM) was conducted in the Jaffna district during November 2012 to January 2015. A representative sample of 3041 infants who received the LJEV at the age of 9 months was followed up actively over telephone interviews on days 1, 3, 14, 30 and 45 for adverse events (AE)...
2016: Ceylon Medical Journal
Fathima Wardha Refai, Nayani P Madarasingha, Rohini Fernandopulle, Nadira Karunaweera
Leishmaniasis is caused by parasitic protozoa of the genus Leishmania. Cutaneous leishmaniasis (CL) is endemic in Sri Lanka with over 3000 cases during the last decade and numbers are increasing. Treatment options available in Sri Lanka for CL include intralesional/intramuscular sodium stibogluconate and cryotherapy. Eight cases of treatment failure with standard therapy are reported from the Dermatology Clinic, Teaching Hospital Anuradhapura. Therapeutic regimes aim for clinical healing, these patients responded poorly to anti-leishmanial therapy, indicating the need for close monitoring, explore alternative treatment options and to investigate for drug resistance in parasites...
July 2016: Tropical Parasitology
Barbara Rath, Jane F Gidudu, Helen Anyoti, Brigid Bollweg, Patrick Caubel, Yeoung-Hwang Chen, David Cornblath, Rohini Fernandopulle, Louis Fries, Jochem Galama, Neville Gibbs, Gualtiero Grilli, Patrick Grogan, Katharina Hartmann, Ulrich Heininger, Michael J Hudson, Hector S Izurieta, Indira Jevaji, Wiltshire M Johnson, James Jones, Brigitte Keller-Stanislawski, Jerome Klein, Katrin Kohl, Panagiotis Kokotis, Yulin Li, Thomas Linder, James Oleske, Georgina Richard, Tarek Shafshak, Michael Vajdy, Virginia Wong, James Sejvar
No abstract text is available yet for this article.
April 4, 2017: Vaccine
H Banneheke, R Fernandopulle, U Gunasekara, A Barua, N Fernando, R Wickremasinghe
Wet mount microscopy is the most commonly used diagnostic method for trichomoniasis in clinical diagnostic services all over the world including Sri Lanka due to its availability, simplicity and is relatively inexpensive. However, Trichomonas culture and PCR are the gold standard tests. Unfortunately, neither the culture nor PCR is available for the diagnosis of trichomoniasis in Sri Lanka. Thus, it is important to validate the wet mount microscopy as it is the only available diagnostic test and has not been validated to date in Sri Lanka...
June 2015: Tropical Biomedicine
Isurujith K Liyanage, Mitrakrishnan R Navinan, A C A Pathirana, H R I S Herath, Jevon Yudhishdran, Nilesh Fernandopulle, Aruna Kulatunga
Methyl Ethyl Ketone Peroxide (MEKP) is a highly toxic clear liquid used as a solvent. It is a strong oxidizing agent and a corrosive. Acute and chronic toxicity can occur as an occupational hazard. Ingestion is associated with corrosive burns leading to stricture formation, inhalational pneumonitis, acidosis, liver failure and renal failure. In this paper we present a case of a young patient who intentionally ingested MEKP. The patient developed multiple complications including proximal intestinal obstruction, acidosis and acute kidney injury...
2015: Journal of Occupational Medicine and Toxicology
Corey L Compton, Michael S Fernandopulle, Rohith T Nagari, Jason K Sello
UNLABELLED: Pupylation is a posttranslational modification peculiar to actinobacteria wherein proteins are covalently modified with a small protein called the prokaryotic ubiquitin-like protein (Pup). Like ubiquitination in eukaryotes, this phenomenon has been associated with proteasome-mediated protein degradation in mycobacteria. Here, we report studies of pupylation in a streptomycete that is phylogentically related to mycobacteria. We constructed mutants of Streptomyces coelicolor lacking PafA (Pup ligase), the proteasome, and the Pup-proteasome system...
September 2015: Journal of Bacteriology
Crispin Corte, Nilesh Fernandopulle, Ana Maria Catuneanu, Daniel Burger, Monica Cesarini, Lydia White, Satish Keshav, Simon Travis
BACKGROUND: The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) accounts for 86% of the variance between observers in the overall assessment of endoscopic severity, but has not been correlated with outcomes. METHODS: Consecutive cases of acute severe colitis (ASC) defined by Truelove and Witts (TW) criteria were retrospectively evaluated. Demographic details, number of TW criteria, prior medical therapy, UCEIS and inpatient medical therapy were recorded...
May 2015: Journal of Crohn's & Colitis
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