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https://www.readbyqxmd.com/read/28944881/folate%C3%A2-targeted-polymeric-micelles-loaded-with-superparamagnetic-iron-oxide-as-a-contrast-agent-for-magnetic-resonance-imaging-of-a-human-tongue-cancer-cell-line
#1
Min-Yi Cui, Zhi Dong, Huasong Cai, Kun Huang, Yi Liu, Zhuangnian Fang, Xiangmin Li, Yanji Luo
The aim of the present study was to investigate the feasibility of using folate‑targeted superparamagnetic iron oxide nanoparticles (SPIO) as a magnetic resonance (MR) contrast agent that targets human tongue cancer cells. Folate‑targeted and folate‑free bilayer micelles composed of a diblock copolymer of polyethylene glycol (PEG) and poly‑caprolactone (PCL) that encapsulated SPIO in their hydrophobic core (SPIO‑PEG‑PCL micelles) were synthesized. The cytotoxicity of each set of micelles towards Tca‑8113 cells was examined using methyl thiazolyl tetrazolium (MTT) assays...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944659/t2-weighted-mr-imaging-of-hepatic-tumor-guided-by-spio-loaded-nanostructured-lipid-carriers-and-ferritin-reporter-genes
#2
Chenying Lu, Jiansong Ji, Xiuliang Zhu, Peifeng Tang, Qian Zhang, Nannan Zhang, Zuhua Wang, Xiaojuan Wang, Weiqian Chen, Jingbo Hu, Yongzhong Du, Risheng Yu
Nowadays, there is a high demand for supersensitive contrast agents for the early diagnostics of hepatocarcinoma. It has been recognized that accurate imaging information is able to be achieved by constructing hepatic tumor specific targeting probes, though it still faces challenges. Here, A AGKGTPSLETTP peptide (A54) functionalized superparamagnetic iron oxide (SPIO)-loaded nanostructured lipid carrier (A54-SNLC), which can be specifically uptaken by hepatoma carcinoma cell (Bel-7402) and exhibited ultralow imaging signal intensity with varied Fe concentration on T2-weighted imaging (T2WI), was first prepared as an effective gene carrier...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944403/prediction-of-disease-free-survival-by-the-pet-ct-radiomic-signature-in-non-small-cell-lung-cancer-patients-undergoing-surgery
#3
Margarita Kirienko, Luca Cozzi, Lidija Antunovic, Lisa Lozza, Antonella Fogliata, Emanuele Voulaz, Alexia Rossi, Arturo Chiti, Martina Sollini
PURPOSE: Radiomic features derived from the texture analysis of different imaging modalities e show promise in lesion characterisation, response prediction, and prognostication in lung cancer patients. The present study aimed to identify an images-based radiomic signature capable of predicting disease-free survival (DFS) in non-small cell lung cancer (NSCLC) patients undergoing surgery. METHODS: A cohort of 295 patients was selected. Clinical parameters (age, sex, histological type, tumour grade, and stage) were recorded for all patients...
September 24, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28944120/treatment-of-male-breast-cancer-by-dual-human-epidermal-growth-factor-receptor-2-her2-blockade-and-response-prediction-using-novel-optical-tomography-imaging-a-case-report
#4
Debasmita Saha, Susan Tannenbaum, Quing Zhu
Male breast cancer, although rare, is on the rise. Prospective clinical trials are unlikely and current management mirrors that of post-menopausal women. Neoadjuvant chemotherapy is widely used and pathologic complete response (pCR) predicts long-term survival. The addition of dual HER2 (human epidermal growth factor receptor 2) blockade has shown the highest pCR rates; however, there is no published data of this approach in men. Also, newer monitoring tools are necessary during a neoadjuvant therapy to help personalize treatment...
July 17, 2017: Curēus
https://www.readbyqxmd.com/read/28943940/leptomeningeal-metastasis-of-pulmonary-large-cell-neuroendocrine-carcinoma-a-case-report-and-review-of-the-literature
#5
Guozi Yang, Zhenyu Pan, Ning Ma, Limei Qu, Tingting Yuan, Xiaochuan Pang, Xu Yang, Lihua Dong, Shixin Liu
Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with a poor prognosis for patients. The common sites of metastases are the liver, adrenal glands, bone and brain. LCNEC rarely metastasizes to the small intestine, ovaries, tonsils, mandible, vulva or spine. To the best of our knowledge, there have been no reports of leptomeningeal metastasis of LCNEC to date. The present case report describes an unusual case of leptomeningeal metastasis from pulmonary LCNEC alongside a review of the literature...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943706/theoretical-predictions-for-spatially-focused-heating-of-magnetic-nanoparticles-guided-by-magnetic-particle-imaging-field-gradients
#6
Rohan Dhavalikar, Carlos Rinaldi
Magnetic nanoparticles in alternating magnetic fields (AMFs) transfer some of the field's energy to their surroundings in the form of heat, a property that has attracted significant attention for use in cancer treatment through hyperthermia and in developing magnetic drug carriers that can be actuated to release their cargo externally using magnetic fields. To date, most work in this field has focused on the use of AMFs that actuate heat release by nanoparticles over large regions, without the ability to select specific nanoparticle-loaded regions for heating while leaving other nanoparticle-loaded regions unaffected...
December 1, 2016: Journal of Magnetism and Magnetic Materials
https://www.readbyqxmd.com/read/28943584/cholangiolocellular-carcinoma-in-a-young-patient-who-showed-sustained-virological-response-after-treatment-for-hepatitis-c-virus-infection
#7
Mitsutaka Osawa, Satoshi Saitoh, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Kenji Ikeda, Keiichi Kinowaki, Takeshi Fujii, Toshio Fukusato, Fukuo Kondo, Hiromitsu Kumada
A 35-year-old male patient who showed sustained virological response (SVR) following treatment for hepatitis C virus infection developed liver cancer. The lesion was identified by imaging studies, with atypical findings suggestive of hepatocellular carcinoma. Partial hepatectomy was performed and the histopathological diagnosis was cholangiolocellular carcinoma (CLC). Only a few cases of CLC have been described in young patients who achieved SVR. Hepatologists should recognize the potential development of CLC even in young patients who achieve SVR, and the need for a close follow-up by imaging studies...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943200/determinants-of-the-overuse-of-imaging-in-low-risk-prostate-cancer-a-systematic-review
#8
REVIEW
Allison H Oakes, Ritu Sharma, Madeline Jackson, Jodi B Segal
BACKGROUND: The overuse of radiologic services, where imaging tests are provided in circumstances where the propensity for harm exceeds the propensity for benefit, comprises a risk to patient safety and a burden on health care systems. Advanced imaging in the staging of low-risk prostate cancer is considered an overused procedure by many professional societies, yet the determinants that drive this phenomenon are not fully appreciated. METHODS: We systematically searched published literature within MEDLINE and Embase from January 1998 to March 2017...
September 21, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28943075/a-novel-absorbable-radiopaque-hydrogel-spacer-to-separate-the-head-of-the-pancreas-and-duodenum-in-radiation-therapy-for-pancreatic-cancer
#9
Avani D Rao, Ziwei Feng, Eun Ji Shin, Jin He, Kevin M Waters, Stephanie Coquia, Robert DeJong, Lauren M Rosati, Lin Su, Dengwang Li, Juan Jackson, Stephen Clark, Jeffrey Schultz, Danielle Hutchings, Seong-Hun Kim, Ralph H Hruban, Theodore L DeWeese, John Wong, Amol Narang, Joseph M Herman, Kai Ding
PURPOSE: We assessed the feasibility and theoretical dosimetric advantages of an injectable hydrogel to increase the space between the head of the pancreas (HOP) and duodenum in a human cadaveric model. METHODS AND MATERIALS: Using 3 human cadaveric specimens, an absorbable radiopaque hydrogel was injected between the HOP and duodenum by way of open laparotomy in 1 case and endoscopic ultrasound (EUS) guidance in 2 cases. The cadavers were subsequently imaged using computed tomography and dissected for histologic confirmation of hydrogel placement...
August 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28943074/local-protocol-variations-for-image-guided-radiation-therapy-in-the-multicenter-dutch-hypofractionation-hypro-trial-impact-of-rectal-balloon-and-mri-delineation-on-anorectal-dose-and-gastrointestinal-toxicity-levels
#10
R C Wortel, W D Heemsbergen, R J Smeenk, M G Witte, A D Krol, F J Pos, L Incrocci
PURPOSE: The phase 3 HYpofractionated irradiation for PROstate cancer (HYPRO) trial randomized patients with intermediate- to high-risk localized prostate cancer to conventionally fractionated (78 Gy in 39 fractions) or hypofractionated (64.6 Gy in 19 fractions) radiation therapy. Differences in techniques and treatment protocols were present between participating centers. This study aimed to compare dose parameters and patient-reported gastrointestinal symptoms between these centers...
August 3, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28943051/a-case-of-adult-congenital-laryngeal-cleft-asymptomatic-until-hypopharynx-cancer-treatment
#11
Kotaro Shimizu, Atsuhiko Uno, Kazuya Takemura, Naoki Ashida, Ryohei Oya, Takahiro Kitamura, Yukinori Takenaka, Yoshifumi Yamamoto
Laryngeal cleft is an anomaly of failed posterior closure of the larynx. Most cases are diagnosed and need treatment early in life due to respiratory and swallowing problems. We report an unusual case of a 66-year-old man with an asymptomatic laryngeal cleft until treatment for hypopharyngeal cancer. During concurrent chemoradiotherapy (CCRT), despite reduced tumor volume, he presented severe dysphagia and dyspnea, followed by severe pneumonia twice. Because CCRT had to be discontinued, a pharyngolaryngectomy was performed for the cancer treatment...
September 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28942682/near-infrared-light-mediated-photochemotherapy-for-efficiently-treating-deep-orthotopic-tumors-guided-by-ultrasound-imaging
#12
Zuhua Wang, Shaoyan Xuan, Wenqi Qiu, Jiang Zhu, Xiaomeng Guo, Wei Li, Hanbo Zhang, Xiuliang Zhu, Yong-Zhong Du, Jian You
Recently, Combined cancer photothermal-chemotherapy has become a highly promising strategy in cancer treatment for its enhanced therapeutic efficacy, controlled drug release and reduced systemic toxicity. Almost all the reported strategies based on photothermal-chemotherapy have only focused on the treatment of superficial or subcutaneous cancer, which are not considered as a more clinically relevant and better predictive models of drug efficacy than orthotopic tumor models. Here, we reported an EphB4 receptor-targeting polymeric nanoplatform containing hollow gold nanospheres (HAuNS) and the anticancer drug paclitaxel (PTX) for cancer photothermal-chemotherapy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28942608/early-anthracycline-induced-cardiotoxicity-monitored-by-echocardiographic-doppler-parameters-combined-with-serum-hs-ctnt
#13
Chu-Jie Zhang, Xiao-Li Pei, Fei-Yan Song, Ye Guo, Qun-Ling Zhang, Xian-Hong Shu, David H Hsi, Lei-Lei Cheng
PURPOSE: As growing numbers of long-term cancer survivors faced with the cardiac side effects by anthracycline treatment, it is necessary to explore the optimal monitoring method for the early detection of cardiac toxicity. METHODS: We conducted a retrospective analysis of 82 consecutive patients with diffuse large B-cell lymphoma treated with chemotherapy. Echocardiographic Doppler imaging-derived Tei index and mitral annular peak systolic velocity (Sm) measured by tissue Doppler imaging TDI, serum high-sensitivity cardiac troponin T (hs-cTnT) levels, and left ventricular ejection fraction (LVEF) by multigated radionuclide angiography (MUGA) were obtained before, after 2-4, and after 6-8 chemotherapy cycles...
September 24, 2017: Echocardiography
https://www.readbyqxmd.com/read/28941921/external-validation-of-contact-surface-area-as-a-predictor-of-post-operative-renal-function-in-patients-undergoing-partial-nephrectomy
#14
Miki Haifler, Benjamin T Ristau, Andrew M Higgins, Marc C Smaldone, Alexander Kutikov, Amnon Zisman, Robert G Uzzo
PURPOSE: To externally validate a mathematical formula for tumor contact surface area (CSA) as a predictor of post-operative renal function in patients undergoing partial nephrectomy for renal cell carcinoma. MATERIALS AND METHODS: A prospectively maintained kidney cancer database was queried for patients who underwent partial nephrectomy between 2014 and 2016. CSA was calculated using data obtained from pre-operative cross sectional imaging. The correlation between CSA and peri-operative variables was examined...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941918/impact-of-lesion-visibility-on-transrectal-ultrasound-on-the-prediction-of-clinically-significant-prostate-cancer-gleason-score-%C3%A2-3-4-with-trus-mri-fusion-biopsy
#15
Kirema Garcia-Reyes, Hao G Nguyen, Ronald J Zagoria, Katsuto Shinohara, Peter R Carroll, Spencer C Behr, Antonio C Westphalen
PURPOSE: The purpose of this study was to estimate the impact of lesion visibility with TRUS on the prediction of CS-PCA with TRUS-MRI fusion biopsy. MATERIALS AND METHODS: This HIPAA-compliant, IRB-approved retrospective study included 178 men (age, 64.7 years; PSA, 8.9 ng/ml) who underwent TRUS-MRI fusion biopsy from January/2013 to September/2016. Visible lesions on MRI were those assigned a PI-RADS v2 score ≥ 3. TRUS was positive when a hypoechoic lesion was identified...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941871/accuracy-of-dermatoscopy-for-the-diagnosis-of-nonpigmented-cancers-of-the-skin
#16
Christoph Sinz, Philipp Tschandl, Cliff Rosendahl, Bengu Nisa Akay, Giuseppe Argenziano, Andreas Blum, Ralph P Braun, Horacio Cabo, Jean-Yves Gourhant, Juergen Kreusch, Aimilios Lallas, Jan Lapins, Ashfaq A Marghoob, Scott W Menzies, John Paoli, Harold S Rabinovitz, Christoph Rinner, Alon Scope, H Peter Soyer, Luc Thomas, Iris Zalaudek, Harald Kittler
BACKGROUND: Nonpigmented skin cancer is common, and diagnosis with the unaided eye is error prone. OBJECTIVE: To investigate whether dermatoscopy improves the diagnostic accuracy for nonpigmented (amelanotic) cutaneous neoplasms. METHODS: We collected a sample of 2072 benign and malignant neoplastic lesions and inflammatory conditions and presented close-up images taken with and without dermatoscopy to 95 examiners with different levels of experience...
September 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28941866/-68-ga-psma-pet-ct-in-prostate-cancer
#17
J R García Garzón, M de Arcocha Torres, R Delgado-Bolton, F Ceci, S Alvarez Ruiz, J Orcajo Rincón, A P Caresia Aróztegui, M J García Velloso, A M García Vicente
Positron emission tomography/computed tomography (PET/CT) with (68)Ga-PSMA is a non-invasive diagnostic technique to image prostate cancer with increased prostate-specific membrane antigen (PSMA) expression. PSMA is a transmembrane protein present in all prostatic tissues. Increased PSMA expression is seen in several malignancies, although prostate cancer is the tumour where it presents higher concentrations. Almost all prostate adenocarcinomas show PSMA expression in most of lesions, primary and metastatic...
September 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28941757/contrast-enhanced-spectral-mammography-as-work-up-tool-in-patients-recalled-from-breast-cancer-screening-has-low-risks-and-might-hold-clinical-benefits
#18
I P L Houben, P Van de Voorde, C R L P N Jeukens, J E Wildberger, L F Kooreman, M L Smidt, M B I Lobbes
OBJECTIVE: Contrast-enhanced spectral mammography (CESM) is a reliable problem solving tool in the work-up of women recalled from breast cancer screening. We evaluated additional findings caused by CESM alone and outweighed them against the disadvantages of this technique. METHODS: From December 2012 to December 2015, all women recalled from screening who underwent CESM were considered for this study. Radiation exposure and number of adverse contrast reactions were analysed...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28941728/preoperative-prediction-of-microvascular-invasion-in-hepatocellular-carcinoma-using-quantitative-image-analysis
#19
Jian Zheng, Jayasree Chakraborty, William C Chapman, Scott Gerst, Mithat Gonen, Linda M Pak, William R Jarnagin, Ronald P DeMatteo, Richard Kg Do, Amber L Simpson, Peter J Allen, Vinod P Balachandran, Michael I D'Angelica, T Peter Kingham, Neeta Vachharajani
BACKGROUND: Microvascular invasion (MVI) is a significant risk factor for early recurrence after resection or transplantation for hepatocellular carcinoma (HCC). Knowledge of MVI status would help guide treatment recommendations but is generally identified after surgery. This study aims to predict MVI preoperatively using quantitative image analysis. STUDY DESIGN: From 2 institutions, 120 patients submitted to resection of HCC from 2003 to 2015 were included. The largest tumor from preoperative CT was subjected to quantitative image analysis, which uses an automated computer algorithm to capture regional variation in CT enhancement patterns...
September 20, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28941641/targeting-tumor-associated-macrophages-the-new-challenge-for-nanomedicine
#20
REVIEW
Fernando Torres Andón, Elisabeth Digifico, Akihiro Maeda, Marco Erreni, Alberto Mantovani, María José Alonso, Paola Allavena
The engineering of new nanomedicines with ability to target and kill or re-educate Tumor Associated Macrophages (TAMs) stands up as a promising strategy to induce the effective switching of the tumor-promoting immune suppressive microenvironment, characteristic of tumors rich in macrophages, to one that kills tumor cells, is anti-angiogenic and promotes adaptive immune responses. Alternatively, the loading of monocytes/macrophages in blood circulation with nanomedicines, may be used to profit from the high infiltration ability of myeloid cells and to allow the drug release in the bulk of the tumor...
September 20, 2017: Seminars in Immunology
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