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Embryo implantation

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https://www.readbyqxmd.com/read/29773831/dnajc17-is-localized-in-nuclear-speckles-and-interacts-with-splicing-machinery-components
#1
A Pascarella, G Ferrandino, S C Credendino, C Moccia, F D'Angelo, B Miranda, C D'Ambrosio, P Bielli, O Spadaro, M Ceccarelli, A Scaloni, C Sette, M De Felice, G De Vita, E Amendola
DNAJC17 is a heat shock protein (HSP40) family member, identified in mouse as susceptibility gene for congenital hypothyroidism. DNAJC17 knockout mouse embryos die prior to implantation. In humans, germline homozygous mutations in DNAJC17 have been found in syndromic retinal dystrophy patients, while heterozygous mutations represent candidate pathogenic events for myeloproliferative disorders. Despite widespread expression and involvement in human diseases, DNAJC17 function is still poorly understood. Herein, we have investigated its function through high-throughput transcriptomic and proteomic approaches...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773310/maternal-concentrations-of-human-chorionic-gonadotrophin-in-very-early-ivf-pregnancies-and-duration-of-pregnancy-a-follow-up-study
#2
Tom G Tanbo, Manuela Zucknick, Anne Eskild
RESEARCH QUESTION: Are maternal concentrations of human chorionic gonadotropin (HCG) on a fixed day after embryo transfer associated with duration of pregnancy? DESIGN: A follow-up study of 1917 singleton pregnancies after IVF was performed. Embryos were cultured for 2 days and maternal HCG concentration quantified on day 12 after embryo transfer. Duration of pregnancy was obtained from the Medical Birth Registry of Norway. Association of HCG concentration (log2-transformed) with duration of pregnancy was estimated as hazard ratios (HR) with 95% confidence intervals (CI) by applying Cox regression proportional hazard models, where time to delivery for pregnancies shortened because of planned Caesarean delivery or induction of labour was treated as censored...
May 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29773228/changes-in-mucins-and-matrix-metalloproteases-in-the-endometrium-of-early-pregnant-alpacas-vicugna-pacos
#3
Daniela E Barraza, Renato Zampini, Silvana A Apichela, Joel I Pacheco, Martin E Argañaraz
South American Camelids (SAC) have unique reproductive features, one of which is that 98% of the pregnancies develop in the left uterine horn. Furthermore, early pregnancy is an uncharacterized process in these species, especially in regard to the ultrastructural, biochemical and genetic changes that the uterine epithelial surface undergoes to allow embryo implantation. The present study describes the uterine horn luminal surface and the characteristics of the mucinous glycocalyx in non-pregnant and early pregnant (15 days) female alpacas...
May 14, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29773104/-knockdown-of-msx2-gene-inhibits-the-expression-of-enamel-matrix-proteins-and-the-enamel-mineralization-in-mouse-ameloblasts
#4
Hao Liu, Jianping Jiang, Qi Gong, Huanbing Tian, Sheng Wang, Juanjuan Zhang, Zhifang Pan, Xiaoying Liu
Objective To study the effect of muscle segment homeodomain homeobox 2 (MSX2) on the expression of enamel matrix protein and the formation of enamel. Methods Immunohistochemical staining was used to detect the expression of MSX2 in mouse tooth embryos and its localization in ameloblasts. The short hairpin RNA (shRNA) of the MSX2 gene was designed and synthesized, and then the annealed double stranded DNA was constructed into the pGMLV-SC5 RNAi lentivirus vector, and finally it was packaged with lentivirus. The lentivirus was used to infect ameloblasts...
March 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29770509/molecular-characteristics-of-granulosa-and-cumulus-cells-and-oocyte-competence-in-nelore-cows-with-low-and-high-numbers-of-antral-follicles
#5
C O Rosa, Lsr Marinho, Pra da Rosa, M P De Cesaro, P A Lunardelli, K C Silva-Santos, A C Basso, V Bordignon, M M Seneda
The aims of this study were to investigate whether the number of antral follicles (AF) in the ovaries of Nelore cows is influenced with the developmental competence of oocytes to reach the blastocyst stage and to quantify the mRNA abundance of genes associated with folliculogenesis and oogenesis in granulosa and cumulus cells. A total of 168 cows were distributed into two experimental groups according to the number of AF, low (≤31) and high AF (≥92), which were determined based on the mean number of AF (61...
May 16, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29766148/endogenous-luteinizing-hormone-concentration-and-ivf-outcome-during-ovarian-stimulation-in-fixed-versus-flexible-gnrh-antagonist-protocols-an-rct
#6
Raffaella Depalo, Paolo Trerotoli, Annarosa Chincoli, Margherita Patrizia Vacca, Giuseppina Lamanna, Ettore Cicinelli
Background: Luteinizing hormone (LH) is essential for normal follicular development and oocyte maturation. In particular, fluctuations of LH during the follicular phase have a significant impact on morphological and functional changes of the oocyte and determine its meiotic status and ability to be fertilized. Objective: This prospective randomized controlled trial examined effects of endogenous follicular phase LH levels on oocyte maturity and IVF outcomes in fixed vs...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29763784/alterations-in-the-distribution-of-actin-and-its-binding-proteins-in-the-porcine-endometrium-during-early-pregnancy-possible-role-in-epithelial-remodeling-and-embryo-adhesion
#7
Beenu Moza Jalali, Pawel Likszo, Aneta Andronowska, Dariusz J Skarzynski
During early pregnancy, uterine epithelial cells undergo major transformations in their cytoskeleton that make the endometrium receptive for conceptus attachment. Actin binding proteins (ABPs) such as cofilin, gelsolin, and vinculin are involved in regulating actin polymerization, severing or crosslinking actin to integrins. However, whether ABPs are involved in epithelial remodeling or embryo adhesion in pigs is unknown. Therefore, the expression and distribution of these proteins were investigated in porcine endometrium on Days 10 and 13 (pre-implantation period), and 16 (attachment phase) of the estrous cycle or pregnancy...
May 8, 2018: Theriogenology
https://www.readbyqxmd.com/read/29761655/fennel-induces-cytotoxic-effects-against-testicular-germ-cells-in-mice-evidences-for-suppressed-pre-implantation-embryo-development
#8
Aram Minas, Gholamreza Najafi, Ali Shalizar Jalali, Mazdak Razi
Foeniculum vulgare (FVE; fennel) is an aromatic plant belonging to Umbelliferae family, which is widely used in traditional societies because of its different pharmaceutical properties. To uncover the fennel-derived essential oil (FVEO)-induced effects on male reproductive potential, 24 mature male albino mice were divided into, control, 0.37, 0.75, and 1.5 mg kg-1 FVEO-received groups. Following 35 days, the animals were euthanized and the testicular tissue and sperm samples were collected. The histological alterations, tubular differentiation (TDI), spermiogenesis (SPI) indices, apoptosis ratio, and RNA damage of germinal cells were analyzed...
May 15, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29757581/transmyometrial-embryo-transfer-as-a-useful-method-to-overcome-difficult-embryo-transfers-a-single-center-retrospective-study
#9
Janisse Ferreri Dos Anjos, Emma Gabriela Portillo Osorio, Joana Peñarrubia, Ester Vidal, Francisco Fábregues Gasol
OBJECTIVE: Pregnancy after an embryo transfer depends largely on embryo quality, endometrial receptivity, and the technique used in the embryo transfer. Embryo transfers have been reported as inevitably traumatic and difficult for 5-7% of patients in assisted reproduction treatment. In these cases, transmyometrial embryo transfer should be considered as a suitable method to overcome difficult embryo transfers. The aim of this study was to report our experience with this technique and analyze its causes, results and complications...
May 14, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29757275/isolation-of-primary-human-decidual-cells-from-the-fetal-membranes-of-term-placentae
#10
Tali Farine, Michael Parsons, Stephen Lye, Oksana Shynlova
The decidua, also known as the pregnant endometrium, is a critically important reproductive tissue. Decidual cells, comprised mainly of decidualized stromal cells and immune cells, are responsible for the secretion of hormonal and inflammatory factors which are critical for successful blastocyst implantation, placental development and play a role in the initiation of labor at term and preterm. Many pregnancy complications can arise from perturbations of a fine balance of different cell populations comprising decidua...
April 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29755412/association-between-progesterone-elevation-on-the-day-of-human-chronic-gonadotropin-trigger-and-pregnancy-outcomes-after-fresh-embryo-transfer-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles
#11
REVIEW
Sandro C Esteves, Gautam Khastgir, Jatin Shah, Kshitiz Murdia, Shweta Mittal Gupta, Durga G Rao, Soumyaroop Dash, Kundan Ingale, Milind Patil, Kunji Moideen, Priti Thakor, Pavitra Dewda
Progesterone elevation (PE) during the late follicular phase of controlled ovarian stimulation in fresh embryo transfer in vitro fertilization (IVF)/intracytoplasmic sperm injection cycles has been claimed to be associated with decreased pregnancy rates. However, the evidence is not unequivocal, and clinicians still have questions about the clinical validity of measuring P levels during the follicular phase of stimulated cycles. We reviewed the existing literature aimed at answering four relevant clinical questions, namely (i) Is gonadotropin type associated with PE during the follicular phase of stimulated cycles? (ii) Is PE on the day of human chorionic gonadotropin (hCG) associated with negative fresh embryo transfer IVF/intracytoplasmic sperm injection (ICSI) cycles outcomes in all patient subgroups? (iii) Which P thresholds are best to identify patients at risk of implantation failure due to PE in a fresh embryo transfer? and (iv) Should a freeze all policy be adopted in all the cycles with PE on the day of hCG? The existing evidence indicates that late follicular phase progesterone rise in gonadotropin releasing analog cycles is mainly caused by the supraphysiological stimulation of granulosa cells with exogenous follicle-stimulating hormone...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29740882/differential-gene-expression-of-eph-ephrin-a1-and-lepr-lep-with-high-or-low-number-of-embryos-in-pigs-during-implantation
#12
Y Fu, R V Knox, L Li, S Ren
The objective of this study was to ascertain whether mRNA and protein expressions of implantation-related genes (erythropoietin-producing hepatocellular receptor-ligand A1, Eph-ephrin A1 and leptin receptor-leptin, LEPR-LEP) differed between pigs with high and low number of embryos, and whether these differences in gene expression might affect embryo implantation. Experimental pig groups (n = 24) for high and low number of embryos were prepared by altering the number of eggs ovulated in pre-pubertal gilts treated with 1...
May 8, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29740477/determination-of-oocyte-manipulation-zygote-manipulation-and-genome-reprogramming-effects-on-the-transcriptomes-of-bovine-blastocysts
#13
Byungkuk Min, Jung S Park, Yong-Kook Kang
Somatic cell nuclear transfer (scNT) embryos suffer from damage caused by micro-operation (manipulation) and inefficient genome reprograming that hinder their normal development at different levels and in distinct ways. These two effects are inseparable in the nature of the scNT embryo, although methods to separately measure them are needed to improve scNT technology and evaluate incoming reprogramming tools. As an attempt to meet these demands, we made bovine sham nuclear-transfer (shNT) blastocysts, special embryos made with a standard nuclear-transfer procedure at the zygote stage, while retaining an intact genome...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29739285/association-between-mir-605a-g-mir-608g-c-mir-631i-d-mir-938c-t-and-mir-1302-3c-t-polymorphisms-and-risk-of-recurrent-implantation-failure
#14
Hyun Ah Lee, Eun Hee Ahn, Hyo Geun Jang, Jung Oh Kim, Ji Hyang Kim, Yu Bin Lee, Woo Sik Lee, Nam Keun Kim
Recurrent implantation failure (RIF) is diagnosed when pregnancy failure occurs after 2 consecutive in vitro fertilization-embryo transfers (IVF-ET) to the endometrium using at least 4 high-quality embryos. MicroRNAs (miRNAs) are a class of small noncoding RNA and reported to play an important role in cell proliferation as well as implantation process. Recently, it has been reported that miRNA can regulate RIF occurrence. So, we were to examine the association between the specific miRNA polymorphisms and RIF in Korean women...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29737471/does-the-endometrial-receptivity-array-really-provide-personalized-embryo-transfer
#15
Rawad Bassil, Robert Casper, Nivin Samara, Tzu-Bou Hsieh, Eran Barzilay, Raoul Orvieto, Jigal Haas
PURPOSE: The aim of the present study was to determine the percentage of infertility patients who are diagnosed with a non-receptive endometrium according to the endometrial receptivity array (ERA) test and to examine whether adjusting the embryo transfer day according to the proposed shift in the window of implantation improves the pregnancy rate compared to non-ERA-tested patients. METHODS: A single-center retrospective cohort study, including 53 consecutive good prognosis patients (0-2 previous frozen embryo transfers) admitted to our IVF unit for a mock cycle prior to their frozen day-5 embryo (blastocyst) transfer cycle...
May 8, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29735973/baicalein-enhances-migration-and-invasion-of-extravillous-trophoblasts-via-activation-of-the-nf-%C3%AE%C2%BAb-pathway
#16
Jia Liu, Shan-Shan Lv, Zi-Yi Fu, Li-Li Hou
BACKGROUND Baicalein, one of the major flavonoids in the plant [i]Scutellaria baicalensis[/i], can regulate the invasive ability of cancer cells. The invasion of trophoblasts is similar to the invasion of tumor cells into host tissues. The appropriate invasion of trophoblast cells into the endometrium is an important factor for successful embryo implantation. In this research, we investigated the effect of baicalein on the invasion and migration of trophoblast cells and its possible molecular mechanism. MATERIAL AND METHODS We treated HTR-8/SVneo cells with different concentrations (0, 0...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29734084/association-between-early-%C3%AE-hcg-kinetics-blastocyst-morphology-and-pregnancy-outcome-in-a-single-blastocyst-transfer-program
#17
Jean-Maxime Girard, Mathilde Simorre, Florence Leperlier, Arnaud Reignier, Tiphaine Lefebvre, Paul Barrière, Thomas Fréour
OBJECTIVE(S): Beta human chorionic gonadotrophin (β-hCG) is secreted by placenta and detectable in maternal serum a few days after embryo implantation. The evolution of β-hCG serum levels is commonly used to confirm early pregnancy and differentiate normal pregnancies from others, either in spontaneous pregnancies or after IVF. However, little is known on the eventual link between blastocyst quality in IVF, pregnancy outcome, and βhCG kinetics. The objective was to evaluate the association between early βhCG rise, blastocyst morphology and pregnancy evolution in a single-blastocyst transfer program STUDY DESIGN: This retrospective cohort study was conducted in a University-affiliated IVF center in 441 couples undergoing 455 single blastocyst transfer cycles leading to a positive pregnancy test 12 days afterwards...
April 30, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29728797/potential-of-testicular-sperm-to-support-embryonic-development-to-the-blastocyst-stage-is-comparable-to-that-of-ejaculated-sperm
#18
Sun-Hee Lee, Chan Woo Park, Yong-Pil Cheon, Chun Kyu Lim
PURPOSE: Recent studies have shown that improved clinical outcomes can be achieved by transferring blastocysts rather than cleavage-stage embryos. However, blastocyst transfer is not performed in all patients. The aim of this study was to compare clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles using testicular sperm (TE) with those of ICSI cycles using ejaculated sperm (EJ). METHODS: ICSI was performed using EJ in 141 cycles and TE in 37 cycles...
May 5, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29727537/-testicular-histology-does-not-affect-the-clinical-outcomes-of-icsi-in-men-with-non-obstructive-azoospermia
#19
Yan-Rong Kuai, Zhan-Ju He, Sheng Wang, Kai Zhang, Cheng Zeng, Liang Chen, Qing Xue, Jing Shang, Hui-Xia Yang, Yang Xu
Objective: To investigate whether testicular histology influences the clinical outcomes of intracytoplasmic sperm injection (ICSI) in men with non-obstructive azoospermia (NOA). METHODS: We retrospectively analyzed the clinical data about 73 cases of NOA undergoing ICSI, including 105 ICSI cycles and 79 embryo transfer cycles. The infertility of the patients was attributed to male factors only or both male and female tube factors and the females' age was ≤38 years...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726999/insulin-regulates-glycogen-synthesis-in-human-endometrial-glands-through-increased-gys2
#20
Clare A Flannery, Gina H Choe, Andrew G Fleming, Katherine M Cooke, Caitlin C Radford, Pinar H Kodaman, Michael J Jurczak, Richard G Kibbey, Hugh S Taylor
Context: Glycogen synthesis is a critical metabolic function of the endometrium to prepare for successful implantation and sustain embryo development. Yet regulation of endometrial carbohydrate metabolism is poorly characterized. While glycogen synthesis is attributed to progesterone, we previously found that the metabolic B isoform of insulin receptor is maximally expressed in secretory phase endometrium indicating a potential role of insulin in glucose metabolism. Objective: We sought to determine whether insulin or progesterone regulates glycogen synthesis in human endometrium...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
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