Thomas G Beach, Lucia I Sue, Sarah Scott, Anthony J Intorcia, Jessica E Walker, Richard A Arce, Michael J Glass, Claryssa I Borja, Madison P Cline, Spencer J Hemmingsen, Sanaria Qiji, Analisa Stewart, Kayleigh N Martinez, Addison Krupp, Rylee McHattie, Monica Mariner, Ileana Lorenzini, Angela Kuramoto, Kathy E Long, Cécilia Tremblay, Richard J Caselli, Bryan K Woodruff, Steven Z Rapscak, Christine M Belden, Danielle Goldfarb, Parichita Choudhury, Erika D Driver-Dunckley, Shyamal H Mehta, Marwan N Sabbagh, Holly A Shill, Alireza Atri, Charles H Adler, Geidy E Serrano
Cerebral white matter rarefaction (CWMR) was considered by Binswanger and Alzheimer to be due to cerebral arteriolosclerosis. Renewed attention came with CT and MR brain imaging, and neuropathological studies finding a high rate of CWMR in Alzheimer disease (AD). The relative contributions of cerebrovascular disease and AD to CWMR are still uncertain. In 1181 autopsies by the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND), large-format brain sections were used to grade CWMR and determine its vascular and neurodegenerative correlates...
May 25, 2023: Journal of Neuropathology and Experimental Neurology