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principal component analysis osteoarthritis

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https://www.readbyqxmd.com/read/29599826/gas-chromatography-time-of-flight-mass-spectrometry-based-metabonomics-of-changes-in-the-urinary-metabolic-profile-in-osteoarthritic-rats
#1
Hui Jiang, Jian Liu, Xiu-Juan Qin, Yuan-Yuan Chen, Jia-Rong Gao, Mei Meng, Yuan Wang, Ting Wang
The aim of the present study was to explore changes in the urinary metabolic spectrum in rats with knee osteoarthritis, using gas chromatography-time of flight/mass spectrometry (GC-TOF/MS) to determine the metabonomic disease pathogenesis. Sprague-Dawley rats were randomly divided into the control and model groups (n=8/group), and 20 µl of 4% papain and 0.03 M L-cysteine was injected into the right knee on days 1, 3 and 7 to establish the knee osteoarthritis model. Following 14 days, urine was collected over 12 h and cartilage ultrastructural damage was assessed by hematoxylin-eosin staining...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29551687/application-of-global-metabolomic-profiling-of-synovial-fluid-for-osteoarthritis-biomarkers
#2
Alyssa K Carlson, Rachel A Rawle, Erik Adams, Mark C Greenwood, Brian Bothner, Ronald K June
Osteoarthritis affects over 250 million individuals worldwide. Currently, there are no options for early diagnosis of osteoarthritis, demonstrating the need for biomarker discovery. To find biomarkers of osteoarthritis in human synovial fluid, we used high performance liquid-chromatography mass spectrometry for global metabolomic profiling. Metabolites were extracted from human osteoarthritic (n = 5), rheumatoid arthritic (n = 3), and healthy (n = 5) synovial fluid, and a total of 1233 metabolites were detected...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29548273/translation-cross-cultural-adaptation-and-validation-of-the-dutch-international-hip-outcome-tool-33-ihot-33-nl-in-young-physically-active-individuals-with-symptomatic-hip-joint-pathology
#3
Marsha Tijssen, Igor Tak, Janine Stubbe, Daniel Haverkamp, Enrico de Visser, Maria Nijhuis-van der Sanden, Robert van Cingel
Study Design Prospective cohort. Background The International Hip Outcome Tool 33 (iHOT-33), developed in English, has been shown to be a valid and reliable questionnaire for young physically active individuals with symptomatic hip joint pathology. Objectives Translate and validate the iHOT-33 in Dutch (iHOT-33 NL) in the target population. Methods Translation and cross-cultural adaptation of the iHOT-33 was performed following existing guidelines. Young to middle-aged (18-50 years), active (Tegner score ≥ 3) individuals presenting with symptomatic hip joint related pain (Numeric Pain Rating Score (NPRS) ≥ 1) in primary healthcare/hospital setting were included...
March 16, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29520913/delineation-between-different-components-of-chronic-pain-using-dimension-reduction-an-asl-fmri-study-in-hand-osteoarthritis
#4
D Keszthelyi, Q Aziz, J K Ruffle, O O'Daly, D Sanders, K Krause, S C Williams, M A Howard
BACKGROUND: Traditional psychometric measures aimed at characterizing the pain experience often show considerable overlap, due to interlinked affective and modulatory processes under central nervous system control. Neuroimaging studies have been employed to investigate this complexity of pain processing, in an attempt to provide a quantifiable, adjunctive description of pain perception. In this exploratory study, we examine psychometric and neuroimaging data from 38 patients with painful osteoarthritis of the carpometacarpal joint...
March 9, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29314768/medium-and-long-chain-acylcarnitines-are-associated-with-osteoarthritis-severity-and-arterial-stiffness-in-end-stage-osteoarthritis-patients-a-case-control-study
#5
Kaspar Tootsi, Jaak Kals, Mihkel Zilmer, Kaido Paapstel, Aigar Ottas, Aare Märtson
AIM: Arterial pathology has been suggested to be involved in osteoarthritis (OA). Metabolic profiling enables the determination of low-molecular-weight molecules, which might further explain the pathogenesis of OA and its relationship with cardiovascular diseases (CVD). The aim of this study was to compare the metabolic profile of lipid metabolism-related compounds and arterial stiffness in OA patients and in controls. METHOD: The serum of 70 end-stage OA patients prior to joint replacement surgery and 82 age-matched controls were analyzed by the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria) using the targeted metabolomic approach...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29251373/altered-erector-spinae-activity-and-trunk-motion-occurs-with-moderate-and-severe-unilateral-hip-oa
#6
Janice Moreside, Ivan Wong, Derek Rutherford
People with hip osteoarthritis (OA) demonstrate altered movement patterns in the hip joint, as well as the pelvis and spine. While kinematic changes have been described in the literature, little is known about the associated erector spinae (ES) activity. Increased or prolonged ES activity may contribute to the low back pain often associated with hip OA. Using a cross-sectional cohort study, 3D trunk motions and ES surface electromyography were recorded on 19 individuals with severe OA (SOA), 20 with moderate hip OA (MOA), and 19 asymptomatic (ASYM) individuals during treadmill walking, using standardized collection and processing procedures...
December 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#7
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29136797/unparalleled-sample-treatment-throughput-for-proteomics-workflows-relying-on-ultrasonic-energy
#8
Susana Jorge, J E Araújo, F M Pimentel-Santos, Jaime C Branco, Hugo M Santos, Carlos Lodeiro, J L Capelo
We report on the new microplate horn ultrasonic device as a powerful tool to speed proteomics workflows with unparalleled throughput. 96 complex proteomes were digested at the same time in 4min. Variables such as ultrasonication time, ultrasonication amplitude, and protein to enzyme ratio were optimized. The "classic" method relying on overnight protein digestion (12h) and the sonoreactor-based method were also employed for comparative purposes. We found the protein digestion efficiency homogeneously distributed in the entire microplate horn surface using the following conditions: 4min sonication time and 25% amplitude...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29121669/application-and-interpretation-of-functional-data-analysis-techniques-to-differential-scanning-calorimetry-data-from-lupus-patients
#9
Sarah K Kendrick, Qi Zheng, Nichola C Garbett, Guy N Brock
BACKGROUND: DSC is used to determine thermally-induced conformational changes of biomolecules within a blood plasma sample. Recent research has indicated that DSC curves (or thermograms) may have different characteristics based on disease status and, thus, may be useful as a monitoring and diagnostic tool for some diseases. Since thermograms are curves measured over a range of temperature values, they are considered functional data. In this paper we apply functional data analysis techniques to analyze differential scanning calorimetry (DSC) data from individuals from the Lupus Family Registry and Repository (LFRR)...
2017: PloS One
https://www.readbyqxmd.com/read/29107572/trapeziometacarpal-joint-contact-varies-between-men-and-women-during-three-isometric-functional-tasks
#10
Marco T Y Schneider, Ju Zhang, Joseph J Crisco, Arnold-Peter C Weiss, Amy L Ladd, Kumar Mithraratne, Poul Nielsen, Thor Besier
Trapeziometacarpal (TMC) joint osteoarthritis (OA) affects women two to six times more than men, and is influenced by stresses and strains in the cartilage. The purpose of this study was to characterise sex and age differences in contact area and peak stress location of the healthy TMC joint during three isometric tasks including pinch, grasp and jar twist. CT images of the hand from 50 healthy adult men and women were used to create a statistical shape model that was used to create finite element models for each subject and task...
December 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28904358/monitoring-osteoarthritis-progression-using-near-infrared-nir-spectroscopy
#11
Isaac O Afara, Indira Prasadam, Zohreh Arabshahi, Yin Xiao, Adekunle Oloyede
We demonstrate in this study the potential of near infrared (NIR) spectroscopy as a tool for monitoring progression of cartilage degeneration in an animal model. Osteoarthritic degeneration was artificially induced in one joint in laboratory rats, and the animals were sacrificed at four time points: 1, 2, 4, and 6 weeks (3 animals/week). NIR spectra were acquired from both (injured and intact) knees. Subsequently, the joint samples were subjected to histological evaluation and glycosaminoglycan (GAG) content analysis, to assess disease severity based on the Mankin scoring system and to determine proteoglycan loss, respectively...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899433/wearable-sensors-to-predict-improvement-following-an-exercise-intervention-in-patients-with-knee-osteoarthritis
#12
Dylan Kobsar, Sean T Osis, Jeffrey E Boyd, Blayne A Hettinga, Reed Ferber
BACKGROUND: Muscle strengthening exercises consistently demonstrate improvements in the pain and function of adults with knee osteoarthritis, but individual response rates can vary greatly. Identifying individuals who are more likely to respond is important in developing more efficient rehabilitation programs for knee osteoarthritis. Therefore, the purpose of this study was to determine if pre-intervention multi-sensor accelerometer data (e.g., back, thigh, shank, foot accelerometers) and patient reported outcome measures (e...
September 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28754420/identifying-changes-in-gait-waveforms-following-a-strengthening-intervention-for-women-with-knee-osteoarthritis-using-principal-components-analysis
#13
Elora C Brenneman, Monica R Maly
Lower limb strengthening exercise is pivotal for the management of symptoms related to knee osteoarthritis (OA). Though improvement in clinical symptoms is well documented, concurrent changes in gait biomechanics are ill-defined. This may occur because discrete analyses miss changes following an intervention, analyses limited to the knee undermine potential mechanical trade-offs at other joints, or strengthening interventions not been designed based on biomechanical principles. The purpose of this study was to characterize differences in entire gait waveforms for sagittal plane ankle, knee, and hip angles and external moments; the knee adduction moment; and frontal plane hip angle and moment following 12-weeks of a previously designed novel lower limb strengthening program...
July 11, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28671032/measuring-the-operative-treatment-effect-in-end-stage-ankle-arthritis-are-we-asking-the-right-questions-a-cofas-multicenter-study
#14
Kevin J Wing, Nuria Chapinal, Marcus P Coe, Timothy R Daniels, Mark Glazebrook, Peter Dryden, Alastair Younger, Murray J Penner, Jason M Sutherland
BACKGROUND: Foot and ankle surgeons are increasingly relying on patient-reported outcome measures (PROMs) such as the Ankle Osteoarthritis Scale (AOS) to evaluate treatment options. The objectives of this retrospective cohort study were 2-fold: (1) to examine the AOS instrument using psychometric analysis and (2) to revise the questions on the AOS to improve the effect of questions on the score and remove redundancies. METHODS: Pre- and postoperative patient scores were obtained from AOS questionnaires in the COFAS Prospective Ankle Reconstruction Database, a cohort of patients operatively treated for end-stage ankle arthritis...
October 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28668080/psychometric-evaluation-of-the-canine-brief-pain-inventory-in-a-swedish-sample-of-dogs-with-pain-related-to-osteoarthritis
#15
Ann Essner, Lena Zetterberg, Karin Hellström, Pia Gustås, Hans Högberg, Rita Sjöström
BACKGROUND: To evaluate intervention, implement evidence-based practice and enhance the welfare of dogs with naturally occurring osteoarthritis (OA), access to valid, reliable and clinically relevant outcome measures is crucial for researchers, veterinarians and rehabilitation practitioners. The objectives of the present study were to translate and evaluate psychometric properties, in terms of internal consistency and construct validity, of the owner-reported measure canine brief pain inventory (CBPI) in a Swedish sample of dogs with pain related to OA...
July 1, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28583727/validating-the-forgotten-joint-score-12-in-patients-after-acl-reconstruction
#16
Henrik Behrend, Karlmeinrad Giesinger, Vilijam Zdravkovic, Johannes M Giesinger
BACKGROUND: The forgotten joint score-12 (FJS-12), used to measure postoperative joint awareness, has been extensively validated to assess outcomes after arthroplasty, however the new score has never been validated in evaluating anterior cruciate ligament (ACL) reconstruction. The purpose of our study was to validate the FJS-12 versus the knee injury and osteoarthritis outcome score (KOOS) for patients who have undergone ACL reconstruction. METHODS: All patients who had undergone ACL reconstruction with the same arthroscopic surgical technique at our institution between 2011 and 2014 (medium-term follow-up group (M-FU)) or between 2000 and 2005 (long-term follow-up group (L-FU)) were considered for inclusion in the study...
June 2, 2017: Knee
https://www.readbyqxmd.com/read/28535749/analysis-of-change-in-gait-in-the-ovine-stifle-normal-injured-and-anterior-cruciate-ligament-reconstructed
#17
B J Heard, J E Beveridge, M Atarod, E J O'Brien, C Rolian, C B Frank, D A Hart, N G Shrive
BACKGROUND: Many patients who undergo anterior cruciate ligament (ACL) reconstructive surgery develop post-traumatic osteoarthritis (PTOA). ACL reconstructive surgery may not fully restore pre-injury joint biomechanics, thereby resulting in further joint damage and contributing to the development of PTOA. In an ovine model of idealized ACL reconstruction (ACL-R), it has been shown that signs of PTOA develop within surgical joints by 20 weeks post-surgery. The aim of the present study was to investigate whether altered kinematics contribute to early PTOA development within ACL-R joints of the ovine injury model by comparing the gait of these surgical animals to the gait of a stable normal control group, and an unstable injury group in which the ACL and medial collateral ligament (MCL) had been transected...
May 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28461019/retracted-polar-and-apolar-extra-virgin-olive-oil-and-leaf-extracts-as-a-promising-anti-inflammatory-natural-treatment-for-osteoarthritis
#18
Houda Nsir, Marta Anna Szychlinska, Venera Cardile, Adriana Carol Eleonora Graziano, Rosanna Avola, Hanen Esafi, Alessandra Bendini, Mokhtar Zarouk, Carla Loreto, Venerando Rapisarda, Paola Castrogiovanni, Giuseppe Musumeci
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Authors. An anonymous reader made the authors aware of potential errors in the presentation and the experimental design for the Western blot data in Figure 3. Upon thorough investigation the authors concluded that in fact, in addition to an honest error (wrong image selected for inclusion into the article), the experimental design was not state-of-the-art in that the loading controls were run on parallel gels rather than on the gels to be probed for iNOS and collagen II...
May 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28458186/dual-belt-treadmill-familiarization-implications-for-knee-function-in-moderate-knee-osteoarthritis-compared-to-asymptomatic-controls
#19
Derek Rutherford, Matthew Baker, Ivan Wong, William Stanish
BACKGROUND: Effect of treadmill familiarization on knee function in osteoarthritis is not clear. Purpose was to determine whether spatiotemporal characteristics, knee joint biomechanics and muscle activation patterns change as individuals with and without medial compartment knee osteoarthritis familiarize to dual-belt treadmill walking over 6min. METHODS: 20 individuals with knee osteoarthritis and 20 asymptomatic controls walked at a self-selected speed. Spatiotemporal characteristics, sagittal plane joint motions, sagittal and frontal plane moments and knee joint muscle activation patterns, amplitude normalized to maximum isometric contractions were analyzed...
June 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28451863/variations-in-knee-kinematics-after-acl-injury-and-after-reconstruction-are-correlated-with-bone-shape-differences
#20
Drew A Lansdown, Valentina Pedoia, Musa Zaid, Keiko Amano, Richard B Souza, Xiaojuan Li, C Benjamin Ma
BACKGROUND: The factors that contribute to the abnormal knee kinematics after anterior cruciate ligament (ACL) injury and ACL reconstruction remain unclear. Bone shape has been implicated in the development of hip and knee osteoarthritis, although there is little knowledge about the effects of bone shape on knee kinematics after ACL injury and after ACL reconstruction. QUESTIONS/QUESTIONS: (1) What is the relationship between bony morphology with alterations in knee kinematics after ACL injury? (2) Are baseline bone shape features related to abnormal knee kinematics at 12 months after ACL reconstruction? METHODS: Thirty-eight patients (29 ± 8 years, 21 men) were prospectively followed after acute ACL injury and before ligamentous reconstruction...
October 2017: Clinical Orthopaedics and related Research
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