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principal component analysis osteoarthritis

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https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#1
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29136797/unparalleled-sample-treatment-throughput-for-proteomics-workflows-relying-on-ultrasonic-energy
#2
Susana Jorge, J E Araújo, F M Pimentel-Santos, Jaime C Branco, Hugo M Santos, Carlos Lodeiro, J L Capelo
We report on the new microplate horn ultrasonic device as a powerful tool to speed proteomics workflows with unparalleled throughput. 96 complex proteomes were digested at the same time in 4min. Variables such as ultrasonication time, ultrasonication amplitude, and protein to enzyme ratio were optimized. The "classic" method relying on overnight protein digestion (12h) and the sonoreactor-based method were also employed for comparative purposes. We found the protein digestion efficiency homogeneously distributed in the entire microplate horn surface using the following conditions: 4min sonication time and 25% amplitude...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29121669/application-and-interpretation-of-functional-data-analysis-techniques-to-differential-scanning-calorimetry-data-from-lupus-patients
#3
Sarah K Kendrick, Qi Zheng, Nichola C Garbett, Guy N Brock
BACKGROUND: DSC is used to determine thermally-induced conformational changes of biomolecules within a blood plasma sample. Recent research has indicated that DSC curves (or thermograms) may have different characteristics based on disease status and, thus, may be useful as a monitoring and diagnostic tool for some diseases. Since thermograms are curves measured over a range of temperature values, they are considered functional data. In this paper we apply functional data analysis techniques to analyze differential scanning calorimetry (DSC) data from individuals from the Lupus Family Registry and Repository (LFRR)...
2017: PloS One
https://www.readbyqxmd.com/read/29107572/trapeziometacarpal-joint-contact-varies-between-men-and-women-during-three-isometric-functional-tasks
#4
Marco T Y Schneider, Ju Zhang, Joseph J Crisco, Arnold-Peter C Weiss, Amy L Ladd, Kumar Mithraratne, Poul Nielsen, Thor Besier
Trapeziometacarpal (TMC) joint osteoarthritis (OA) affects women two to six times more than men, and is influenced by stresses and strains in the cartilage. The purpose of this study was to characterise sex and age differences in contact area and peak stress location of the healthy TMC joint during three isometric tasks including pinch, grasp and jar twist. CT images of the hand from 50 healthy adult men and women were used to create a statistical shape model that was used to create finite element models for each subject and task...
December 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28904358/monitoring-osteoarthritis-progression-using-near-infrared-nir-spectroscopy
#5
Isaac O Afara, Indira Prasadam, Zohreh Arabshahi, Yin Xiao, Adekunle Oloyede
We demonstrate in this study the potential of near infrared (NIR) spectroscopy as a tool for monitoring progression of cartilage degeneration in an animal model. Osteoarthritic degeneration was artificially induced in one joint in laboratory rats, and the animals were sacrificed at four time points: 1, 2, 4, and 6 weeks (3 animals/week). NIR spectra were acquired from both (injured and intact) knees. Subsequently, the joint samples were subjected to histological evaluation and glycosaminoglycan (GAG) content analysis, to assess disease severity based on the Mankin scoring system and to determine proteoglycan loss, respectively...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899433/wearable-sensors-to-predict-improvement-following-an-exercise-intervention-in-patients-with-knee-osteoarthritis
#6
Dylan Kobsar, Sean T Osis, Jeffrey E Boyd, Blayne A Hettinga, Reed Ferber
BACKGROUND: Muscle strengthening exercises consistently demonstrate improvements in the pain and function of adults with knee osteoarthritis, but individual response rates can vary greatly. Identifying individuals who are more likely to respond is important in developing more efficient rehabilitation programs for knee osteoarthritis. Therefore, the purpose of this study was to determine if pre-intervention multi-sensor accelerometer data (e.g., back, thigh, shank, foot accelerometers) and patient reported outcome measures (e...
September 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28754420/identifying-changes-in-gait-waveforms-following-a-strengthening-intervention-for-women-with-knee-osteoarthritis-using-principal-components-analysis
#7
Elora C Brenneman, Monica R Maly
Lower limb strengthening exercise is pivotal for the management of symptoms related to knee osteoarthritis (OA). Though improvement in clinical symptoms is well documented, concurrent changes in gait biomechanics are ill-defined. This may occur because discrete analyses miss changes following an intervention, analyses limited to the knee undermine potential mechanical trade-offs at other joints, or strengthening interventions not been designed based on biomechanical principles. The purpose of this study was to characterize differences in entire gait waveforms for sagittal plane ankle, knee, and hip angles and external moments; the knee adduction moment; and frontal plane hip angle and moment following 12-weeks of a previously designed novel lower limb strengthening program...
July 11, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28671032/measuring-the-operative-treatment-effect-in-end-stage-ankle-arthritis-are-we-asking-the-right-questions-a-cofas-multicenter-study
#8
Kevin J Wing, Nuria Chapinal, Marcus P Coe, Timothy R Daniels, Mark Glazebrook, Peter Dryden, Alastair Younger, Murray J Penner, Jason M Sutherland
BACKGROUND: Foot and ankle surgeons are increasingly relying on patient-reported outcome measures (PROMs) such as the Ankle Osteoarthritis Scale (AOS) to evaluate treatment options. The objectives of this retrospective cohort study were 2-fold: (1) to examine the AOS instrument using psychometric analysis and (2) to revise the questions on the AOS to improve the effect of questions on the score and remove redundancies. METHODS: Pre- and postoperative patient scores were obtained from AOS questionnaires in the COFAS Prospective Ankle Reconstruction Database, a cohort of patients operatively treated for end-stage ankle arthritis...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28668080/psychometric-evaluation-of-the-canine-brief-pain-inventory-in-a-swedish-sample-of-dogs-with-pain-related-to-osteoarthritis
#9
Ann Essner, Lena Zetterberg, Karin Hellström, Pia Gustås, Hans Högberg, Rita Sjöström
BACKGROUND: To evaluate intervention, implement evidence-based practice and enhance the welfare of dogs with naturally occurring osteoarthritis (OA), access to valid, reliable and clinically relevant outcome measures is crucial for researchers, veterinarians and rehabilitation practitioners. The objectives of the present study were to translate and evaluate psychometric properties, in terms of internal consistency and construct validity, of the owner-reported measure canine brief pain inventory (CBPI) in a Swedish sample of dogs with pain related to OA...
July 1, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28583727/validating-the-forgotten-joint-score-12-in-patients-after-acl-reconstruction
#10
Henrik Behrend, Karlmeinrad Giesinger, Vilijam Zdravkovic, Johannes M Giesinger
BACKGROUND: The forgotten joint score-12 (FJS-12), used to measure postoperative joint awareness, has been extensively validated to assess outcomes after arthroplasty, however the new score has never been validated in evaluating anterior cruciate ligament (ACL) reconstruction. The purpose of our study was to validate the FJS-12 versus the knee injury and osteoarthritis outcome score (KOOS) for patients who have undergone ACL reconstruction. METHODS: All patients who had undergone ACL reconstruction with the same arthroscopic surgical technique at our institution between 2011 and 2014 (medium-term follow-up group (M-FU)) or between 2000 and 2005 (long-term follow-up group (L-FU)) were considered for inclusion in the study...
June 2, 2017: Knee
https://www.readbyqxmd.com/read/28535749/analysis-of-change-in-gait-in-the-ovine-stifle-normal-injured-and-anterior-cruciate-ligament-reconstructed
#11
B J Heard, J E Beveridge, M Atarod, E J O'Brien, C Rolian, C B Frank, D A Hart, N G Shrive
BACKGROUND: Many patients who undergo anterior cruciate ligament (ACL) reconstructive surgery develop post-traumatic osteoarthritis (PTOA). ACL reconstructive surgery may not fully restore pre-injury joint biomechanics, thereby resulting in further joint damage and contributing to the development of PTOA. In an ovine model of idealized ACL reconstruction (ACL-R), it has been shown that signs of PTOA develop within surgical joints by 20 weeks post-surgery. The aim of the present study was to investigate whether altered kinematics contribute to early PTOA development within ACL-R joints of the ovine injury model by comparing the gait of these surgical animals to the gait of a stable normal control group, and an unstable injury group in which the ACL and medial collateral ligament (MCL) had been transected...
May 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28461019/retracted-polar-and-apolar-extra-virgin-olive-oil-and-leaf-extracts-as-a-promising-anti-inflammatory-natural-treatment-for-osteoarthritis
#12
Houda Nsir, Marta Anna Szychlinska, Venera Cardile, Adriana Carol Eleonora Graziano, Rosanna Avola, Hanen Esafi, Alessandra Bendini, Mokhtar Zarouk, Carla Loreto, Venerando Rapisarda, Paola Castrogiovanni, Giuseppe Musumeci
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Authors. An anonymous reader made the authors aware of potential errors in the presentation and the experimental design for the Western blot data in Figure 3. Upon thorough investigation the authors concluded that in fact, in addition to an honest error (wrong image selected for inclusion into the article), the experimental design was not state-of-the-art in that the loading controls were run on parallel gels rather than on the gels to be probed for iNOS and collagen II...
May 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28458186/dual-belt-treadmill-familiarization-implications-for-knee-function-in-moderate-knee-osteoarthritis-compared-to-asymptomatic-controls
#13
Derek Rutherford, Matthew Baker, Ivan Wong, William Stanish
BACKGROUND: Effect of treadmill familiarization on knee function in osteoarthritis is not clear. Purpose was to determine whether spatiotemporal characteristics, knee joint biomechanics and muscle activation patterns change as individuals with and without medial compartment knee osteoarthritis familiarize to dual-belt treadmill walking over 6min. METHODS: 20 individuals with knee osteoarthritis and 20 asymptomatic controls walked at a self-selected speed. Spatiotemporal characteristics, sagittal plane joint motions, sagittal and frontal plane moments and knee joint muscle activation patterns, amplitude normalized to maximum isometric contractions were analyzed...
June 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28451863/variations-in-knee-kinematics-after-acl-injury-and-after-reconstruction-are-correlated-with-bone-shape-differences
#14
Drew A Lansdown, Valentina Pedoia, Musa Zaid, Keiko Amano, Richard B Souza, Xiaojuan Li, C Benjamin Ma
BACKGROUND: The factors that contribute to the abnormal knee kinematics after anterior cruciate ligament (ACL) injury and ACL reconstruction remain unclear. Bone shape has been implicated in the development of hip and knee osteoarthritis, although there is little knowledge about the effects of bone shape on knee kinematics after ACL injury and after ACL reconstruction. QUESTIONS/QUESTIONS: (1) What is the relationship between bony morphology with alterations in knee kinematics after ACL injury? (2) Are baseline bone shape features related to abnormal knee kinematics at 12 months after ACL reconstruction? METHODS: Thirty-eight patients (29 ± 8 years, 21 men) were prospectively followed after acute ACL injury and before ligamentous reconstruction...
October 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28411486/the-effect-of-age-and-knee-osteoarthritis-on-muscle-activation-patterns-and-knee-joint-biomechanics-during-dual-belt-treadmill-gait
#15
Derek Rutherford, Matthew Baker, Ivan Wong, William Stanish
PURPOSE: To compare a group of individuals with moderate medial compartment knee osteoarthritis (OA) to both an age-matched asymptomatic group of older adults and younger adults to determine whether differences in knee joint muscle activation patterns and joint biomechanics exist during gait between these three groups. SCOPE: 20 young adults, 20 older adults, and 40 individuals with moderate knee OA were recruited. Using standardized procedures, surface electromyograms were recorded from the vastus lateralis and medialis, rectus femoris and the medial and lateral hamstrings...
April 7, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28093922/toll-like-receptors-and-their-soluble-forms-differ-in-the-knee-and-thumb-basal-osteoarthritic-joints
#16
Goncalo Barreto, Jerker Sandelin, Abdelhakim Salem, Dan C Nordström, Eero Waris
Background and purpose - Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be involved. We examined the relationship between Toll-like receptors (TLRs) and OA in cartilage from 2 joints differing in size and mechanical loading: the first carpometacarpal (CMC-I) and the knee. Patients and methods - Samples of human cartilage obtained from OA CMC-I and knee joints were immunostained for TLRs (1-9) and analyzed using histomorphometry and principal component analysis (PCA)...
June 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28090441/principal-component-analysis-t1%C3%AF-voxel-based-relaxometry-of-the-articular-cartilage-a-comparison-of-biochemical-patterns-in-osteoarthritis-and-anterior-cruciate-ligament-subjects
#17
Valentina Pedoia, Colin Russell, Allison Randolph, Xiaojuan Li, Sharmila Majumdar
BACKGROUND: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR)...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28029358/analysis-of-an-early-intervention-distal-femoral-resurfacing-implant-for-medial-osteoarthritis
#18
Miriam Chaudhary, Peter S Walker
A design concept was formulated for implants to treat medial osteoarthritis of the knee, using a metal plate resurfacing of the tibia plateau and a plastic bearing embedded in the distal end of the femur. A finite element analysis was carried out to determine whether a metal backing would be needed for the femoral component, and to what extent the stress and strain distribution in the trabecular bone surrounding the implant would match the normal intact condition. The CT scans from three knees scheduled for unicompartmental replacement were selected to generate computer models with variable bone densities in each element to cover a range of density patterns...
October 6, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27973527/the-nature-of-age-related-differences-in-knee-function-during-walking-implication-for-the-development-of-knee-osteoarthritis
#19
Katherine A Boyer, Thomas P Andriacchi
BACKGROUND: Changes in knee kinematics have been identified in the early stages of osteoarthritis (OA). However, there is a paucity of information on the nature of kinematic change that occur with aging prior to the development of OA, This study applied a robust statistical method (Principal Component Analysis) to test the hypothesis that coupling between primary (flexion) and secondary (anterior-posterior translation, internal-external rotation) joint motions in walking would differ for age groupings of healthy subjects...
2016: PloS One
https://www.readbyqxmd.com/read/27896800/principal-component-analysis-in-the-evaluation-of-osteoarthritis
#20
Stephanie E Calce, Helen K Kurki, Darlene A Weston, Lisa Gould
OBJECTIVES: The purpose of this study is to demonstrate advantages of principal component analysis (PCA) as a standardized procedure in the evaluation of osteoarthritis (OA) in a skeletal series to: (1) compute aggregate scores for joint complexes that accurately capture pathological expression, (2) reveal which variables describe the most sample variation in OA, (3) enable inter- and intra-sample comparison of results, and (4) formulate predictive models from component-based arthritic scores...
March 2017: American Journal of Physical Anthropology
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