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principal component analysis osteoarthritis

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https://www.readbyqxmd.com/read/29809081/prediction-of-knee-joint-contact-forces-from-external-measures-using-principal-component-prediction-and-reconstruction
#1
Christopher M Saliba, Allison L Clouthier, Scott C E Brandon, Michael J Rainbow, Kevin J Deluzio
Abnormal loading of the knee joint contributes to the pathogenesis of knee osteoarthritis. Gait retraining is a non-invasive intervention that aims to reduce knee loads by providing audible, visual, or haptic feedback of gait parameters. The computational expense of joint contact force prediction has limited real-time feedback to surrogate measures of the contact force, such as the knee adduction moment. We developed a method to predict knee joint contact forces using motion analysis and a statistical regression model that can be implemented in near real-time...
May 29, 2018: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/29794610/pain-sensitization-associated-with-non-response-following-physiotherapy-in-people-with-knee-osteoarthritis
#2
Helen O'Leary, Keith M Smart, Niamh A Moloney, Catherine Blake, Catherine M Doody
In knee osteoarthritis (OA) pain sensitization has been linked to a more severe symptomatology, but the prognostic implications of pain sensitivity in people undergoing conservative treatment such as physiotherapy are not established. This study aimed to prospectively investigate the association between features of pain sensitization and clinical outcome (non-response) following guideline-based physiotherapy in people with knee OA. Participants (n=156) with moderate/severe knee OA were recruited from secondary care...
May 22, 2018: Pain
https://www.readbyqxmd.com/read/29773182/essential-elements-in-synovial-fluid-samples-obtained-from-patients-living-in-northern-poland
#3
Pawel Konieczynski, Grzegorz Szreder, Ewelina Tamowska, Marek Wesolowski
Many people after 50 year of life suffer pains caused by osteoarthritis (OA), which make their life difficult and painful. There is a probable association of OA with the concentration of certain elements in body fluids. Therefore the aim of the study was to relate the level of essential elements in synovial fluids of patients with OA with the treatment using antiarthritic drugs. Thus, flame-atomic absorption spectrometry was used to determine the concentrations of Fe, Zn, Cu, Mn, Na, K, Ca and Mg in 74 samples of synovial fluids taken from 36 patients...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29737523/effects-of-osteoarthritis-on-age-at-death-estimates-from-the-human-pelvis
#4
Stephanie E Calce, Helen K Kurki, Darlene A Weston, Lisa Gould
OBJECTIVES: This study examined the degree of error in age-at-death estimates when osteoarthritis (OA) is present in three separate pelvic joint areas: (1) the pubic symphysis, (2) the auricular surface, and (3) the acetabulum from a modern known-age European cemetery sample of adults. MATERIALS AND METHODS: Age-at-death ranged from 17 to 79 years (x̄ =50.9 years; n = 252). OA in the pelvic joints was evaluated using standard ranked categorical scoring. Composite OA scores were derived through principal component analysis...
May 8, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29717032/responsiveness-of-single-versus-composite-measures-of-pain-in-knee-osteoarthritis
#5
Matthew J Parkes, Michael J Callaghan, Leslie Tive, Mark Lunt, David T Felson
OBJECTIVE: In rheumatoid arthritis, composite outcomes constructed from a combination of outcome measures are widely used to enhance responsiveness (sensitivity to change) and comprehensively summarize response. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain is the primary outcome measure in many osteoarthritis (OA) trials. Information from other outcomes, such as rescue medication use and other WOMAC subscales, could be added to create composite outcomes, but the sensitivity of such a composite has not been tested...
May 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29684084/local-and-systemic-inflammatory-lipid-profiling-in-a-rat-model-of-osteoarthritis-with-metabolic-dysregulation
#6
H M de Visser, S C Mastbergen, S Ravipati, P M J Welsing, F C Pinto, F P J G Lafeber, V Chapman, D A Barrett, H Weinans
OBJECTIVE: Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally induced osteoarthritis to investigate the potential role of oxylipins as a marker in the disease process of early osteoarthritis. DESIGN: Forty rats were randomly allocated to a standard or high-fat diet group...
2018: PloS One
https://www.readbyqxmd.com/read/29679859/the-relationship-of-age-activity-and-body-size-on-osteoarthritis-in-weight-bearing-skeletal-regions
#7
Stephanie E Calce, Helen K Kurki, Darlene A Weston, Lisa Gould
This study examined the simultaneous impact of multiple underlying factors on OA expression in weight-bearing joints of the vertebrae and lower limb of a modern European skeletal sample (Lisbon and Sassari). OA was evaluated using standard ranked categorical scoring; composite OA scores derived through principal component analysis. Body size was calculated from postcranial measurements; torsional strength (J) of the femoral midshaft was calculated from three-dimensional surface models, size standardized and used as a proxy for activity...
April 18, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29599826/gas-chromatography-time-of-flight-mass-spectrometry-based-metabonomics-of-changes-in-the-urinary-metabolic-profile-in-osteoarthritic-rats
#8
Hui Jiang, Jian Liu, Xiu-Juan Qin, Yuan-Yuan Chen, Jia-Rong Gao, Mei Meng, Yuan Wang, Ting Wang
The aim of the present study was to explore changes in the urinary metabolic spectrum in rats with knee osteoarthritis, using gas chromatography-time of flight/mass spectrometry (GC-TOF/MS) to determine the metabonomic disease pathogenesis. Sprague-Dawley rats were randomly divided into the control and model groups (n=8/group), and 20 µl of 4% papain and 0.03 M L-cysteine was injected into the right knee on days 1, 3 and 7 to establish the knee osteoarthritis model. Following 14 days, urine was collected over 12 h and cartilage ultrastructural damage was assessed by hematoxylin-eosin staining...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29551687/application-of-global-metabolomic-profiling-of-synovial-fluid-for-osteoarthritis-biomarkers
#9
Alyssa K Carlson, Rachel A Rawle, Erik Adams, Mark C Greenwood, Brian Bothner, Ronald K June
Osteoarthritis affects over 250 million individuals worldwide. Currently, there are no options for early diagnosis of osteoarthritis, demonstrating the need for biomarker discovery. To find biomarkers of osteoarthritis in human synovial fluid, we used high performance liquid-chromatography mass spectrometry for global metabolomic profiling. Metabolites were extracted from human osteoarthritic (n = 5), rheumatoid arthritic (n = 3), and healthy (n = 5) synovial fluid, and a total of 1233 metabolites were detected...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29548273/translation-cross-cultural-adaptation-and-validation-of-the-dutch-international-hip-outcome-tool-33-ihot-33-nl-in-young-physically-active-individuals-with-symptomatic-hip-joint-pathology
#10
Marsha Tijssen, Igor Tak, Janine Stubbe, Daniel Haverkamp, Enrico de Visser, Maria Nijhuis-van der Sanden, Robert van Cingel
Study Design Prospective cohort. Background The international Hip Outcome Tool-33 (iHOT-33), developed in English, has been shown to be a valid and reliable questionnaire for young, physically active individuals with symptomatic hip joint pathology. Objectives To translate and validate the iHOT-33 in Dutch (iHOT-33 NL) in the target population. Methods Translation and cross-cultural adaptation of the iHOT-33 were performed following existing guidelines. Young to middle-aged (18-50 years), active (Tegner activity score of 3 or greater) individuals presenting with symptomatic hip joint-related pain (numeric pain-rating score of 1 or greater) in a primary health care/hospital setting were included...
April 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29520913/delineation-between-different-components-of-chronic-pain-using-dimension-reduction-an-asl-fmri-study-in-hand-osteoarthritis
#11
D Keszthelyi, Q Aziz, J K Ruffle, O O'Daly, D Sanders, K Krause, S C R Williams, M A Howard
BACKGROUND: Traditional psychometric measures aimed at characterizing the pain experience often show considerable overlap, due to interlinked affective and modulatory processes under central nervous system control. Neuroimaging studies have been employed to investigate this complexity of pain processing, in an attempt to provide a quantifiable, adjunctive description of pain perception. In this exploratory study, we examine psychometric and neuroimaging data from 38 patients with painful osteoarthritis of the carpometacarpal joint...
March 9, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29314768/medium-and-long-chain-acylcarnitines-are-associated-with-osteoarthritis-severity-and-arterial-stiffness-in-end-stage-osteoarthritis-patients-a-case-control-study
#12
Kaspar Tootsi, Jaak Kals, Mihkel Zilmer, Kaido Paapstel, Aigar Ottas, Aare Märtson
AIM: Arterial pathology has been suggested to be involved in osteoarthritis (OA). Metabolic profiling enables the determination of low-molecular-weight molecules, which might further explain the pathogenesis of OA and its relationship with cardiovascular diseases (CVD). The aim of this study was to compare the metabolic profile of lipid metabolism-related compounds and arterial stiffness in OA patients and in controls. METHOD: The serum of 70 end-stage OA patients prior to joint replacement surgery and 82 age-matched controls were analyzed by the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria) using the targeted metabolomic approach...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29251373/altered-erector-spinae-activity-and-trunk-motion-occurs-with-moderate-and-severe-unilateral-hip-oa
#13
Janice Moreside, Ivan Wong, Derek Rutherford
People with hip osteoarthritis (OA) demonstrate altered movement patterns in the hip joint, as well as the pelvis and spine. While kinematic changes have been described in the literature, little is known about the associated erector spinae (ES) activity. Increased or prolonged ES activity may contribute to the low back pain often associated with hip OA. Using a cross-sectional cohort study, 3D trunk motions and ES surface electromyography were recorded on 19 individuals with severe OA (SOA), 20 with moderate hip OA (MOA), and 19 asymptomatic (ASYM) individuals during treadmill walking, using standardized collection and processing procedures...
December 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#14
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29136797/unparalleled-sample-treatment-throughput-for-proteomics-workflows-relying-on-ultrasonic-energy
#15
Susana Jorge, J E Araújo, F M Pimentel-Santos, Jaime C Branco, Hugo M Santos, Carlos Lodeiro, J L Capelo
We report on the new microplate horn ultrasonic device as a powerful tool to speed proteomics workflows with unparalleled throughput. 96 complex proteomes were digested at the same time in 4min. Variables such as ultrasonication time, ultrasonication amplitude, and protein to enzyme ratio were optimized. The "classic" method relying on overnight protein digestion (12h) and the sonoreactor-based method were also employed for comparative purposes. We found the protein digestion efficiency homogeneously distributed in the entire microplate horn surface using the following conditions: 4min sonication time and 25% amplitude...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29121669/application-and-interpretation-of-functional-data-analysis-techniques-to-differential-scanning-calorimetry-data-from-lupus-patients
#16
Sarah K Kendrick, Qi Zheng, Nichola C Garbett, Guy N Brock
BACKGROUND: DSC is used to determine thermally-induced conformational changes of biomolecules within a blood plasma sample. Recent research has indicated that DSC curves (or thermograms) may have different characteristics based on disease status and, thus, may be useful as a monitoring and diagnostic tool for some diseases. Since thermograms are curves measured over a range of temperature values, they are considered functional data. In this paper we apply functional data analysis techniques to analyze differential scanning calorimetry (DSC) data from individuals from the Lupus Family Registry and Repository (LFRR)...
2017: PloS One
https://www.readbyqxmd.com/read/29107572/trapeziometacarpal-joint-contact-varies-between-men-and-women-during-three-isometric-functional-tasks
#17
Marco T Y Schneider, Ju Zhang, Joseph J Crisco, Arnold-Peter C Weiss, Amy L Ladd, Kumar Mithraratne, Poul Nielsen, Thor Besier
Trapeziometacarpal (TMC) joint osteoarthritis (OA) affects women two to six times more than men, and is influenced by stresses and strains in the cartilage. The purpose of this study was to characterise sex and age differences in contact area and peak stress location of the healthy TMC joint during three isometric tasks including pinch, grasp and jar twist. CT images of the hand from 50 healthy adult men and women were used to create a statistical shape model that was used to create finite element models for each subject and task...
December 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28904358/monitoring-osteoarthritis-progression-using-near-infrared-nir-spectroscopy
#18
Isaac O Afara, Indira Prasadam, Zohreh Arabshahi, Yin Xiao, Adekunle Oloyede
We demonstrate in this study the potential of near infrared (NIR) spectroscopy as a tool for monitoring progression of cartilage degeneration in an animal model. Osteoarthritic degeneration was artificially induced in one joint in laboratory rats, and the animals were sacrificed at four time points: 1, 2, 4, and 6 weeks (3 animals/week). NIR spectra were acquired from both (injured and intact) knees. Subsequently, the joint samples were subjected to histological evaluation and glycosaminoglycan (GAG) content analysis, to assess disease severity based on the Mankin scoring system and to determine proteoglycan loss, respectively...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899433/wearable-sensors-to-predict-improvement-following-an-exercise-intervention-in-patients-with-knee-osteoarthritis
#19
Dylan Kobsar, Sean T Osis, Jeffrey E Boyd, Blayne A Hettinga, Reed Ferber
BACKGROUND: Muscle strengthening exercises consistently demonstrate improvements in the pain and function of adults with knee osteoarthritis, but individual response rates can vary greatly. Identifying individuals who are more likely to respond is important in developing more efficient rehabilitation programs for knee osteoarthritis. Therefore, the purpose of this study was to determine if pre-intervention multi-sensor accelerometer data (e.g., back, thigh, shank, foot accelerometers) and patient reported outcome measures (e...
September 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28754420/identifying-changes-in-gait-waveforms-following-a-strengthening-intervention-for-women-with-knee-osteoarthritis-using-principal-components-analysis
#20
Elora C Brenneman, Monica R Maly
Lower limb strengthening exercise is pivotal for the management of symptoms related to knee osteoarthritis (OA). Though improvement in clinical symptoms is well documented, concurrent changes in gait biomechanics are ill-defined. This may occur because discrete analyses miss changes following an intervention, analyses limited to the knee undermine potential mechanical trade-offs at other joints, or strengthening interventions not been designed based on biomechanical principles. The purpose of this study was to characterize differences in entire gait waveforms for sagittal plane ankle, knee, and hip angles and external moments; the knee adduction moment; and frontal plane hip angle and moment following 12-weeks of a previously designed novel lower limb strengthening program...
July 11, 2017: Gait & Posture
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