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principal component analysis osteoarthritis

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https://www.readbyqxmd.com/read/28461019/polar-and-apolar-extra-virgin-olive-oil-and-leaf-extracts-as-a-promising-anti-inflammatory-natural-treatment-for-osteoarthritis
#1
Houda Nsir, Marta Anna Szychlinska, Venera Cardile, Adriana Carol Eleonora Graziano, Rosanna Avola, Hanen Esafi, Alessandra Bendini, Mokhtar Zarouk, Carla Loreto, Venerando Rapisarda, Paola Castrogiovanni, Giuseppe Musumeci
Osteoarthritis (OA) is a common joint disease with important socio-economic impact. Looking for a novel natural treatment represents an important challenge and a public health objective. A wide range of previous studies highlighted the antioxidant and anti-inflammatory properties especially of phenolic compounds present in olive oil. Therefore, the aim of this study was to investigate the anti-inflammatory activity of Tunisian Extra Virgin Olive Oil (EVOO) extracts in an in vitro OA model. To this aim we evaluated the polar and apolar olive oil fractions and olive leaf extract...
April 28, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28458186/dual-belt-treadmill-familiarization-implications-for-knee-function-in-moderate-knee-osteoarthritis-compared-to-asymptomatic-controls
#2
Derek Rutherford, Matthew Baker, Ivan Wong, William Stanish
BACKGROUND: Effect of treadmill familiarization on knee function in osteoarthritis is not clear. Purpose was to determine whether spatiotemporal characteristics, knee joint biomechanics and muscle activation patterns change as individuals with and without medial compartment knee osteoarthritis familiarize to dual-belt treadmill walking over 6min. METHODS: 20 individuals with knee osteoarthritis and 20 asymptomatic controls walked at a self-selected speed. Spatiotemporal characteristics, sagittal plane joint motions, sagittal and frontal plane moments and knee joint muscle activation patterns, amplitude normalized to maximum isometric contractions were analyzed...
June 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28451863/variations-in-knee-kinematics-after-acl-injury-and-after-reconstruction-are-correlated-with-bone-shape-differences
#3
Drew A Lansdown, Valentina Pedoia, Musa Zaid, Keiko Amano, Richard B Souza, Xiaojuan Li, C Benjamin Ma
BACKGROUND: The factors that contribute to the abnormal knee kinematics after anterior cruciate ligament (ACL) injury and ACL reconstruction remain unclear. Bone shape has been implicated in the development of hip and knee osteoarthritis, although there is little knowledge about the effects of bone shape on knee kinematics after ACL injury and after ACL reconstruction. QUESTIONS/QUESTIONS: (1) What is the relationship between bony morphology with alterations in knee kinematics after ACL injury? (2) Are baseline bone shape features related to abnormal knee kinematics at 12 months after ACL reconstruction? METHODS: Thirty-eight patients (29 ± 8 years, 21 men) were prospectively followed after acute ACL injury and before ligamentous reconstruction...
April 27, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28411486/the-effect-of-age-and-knee-osteoarthritis-on-muscle-activation-patterns-and-knee-joint-biomechanics-during-dual-belt-treadmill-gait
#4
Derek Rutherford, Matthew Baker, Ivan Wong, William Stanish
PURPOSE: To compare a group of individuals with moderate medial compartment knee osteoarthritis (OA) to both an age-matched asymptomatic group of older adults and younger adults to determine whether differences in knee joint muscle activation patterns and joint biomechanics exist during gait between these three groups. SCOPE: 20 young adults, 20 older adults, and 40 individuals with moderate knee OA were recruited. Using standardized procedures, surface electromyograms were recorded from the vastus lateralis and medialis, rectus femoris and the medial and lateral hamstrings...
April 7, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28093922/toll-like-receptors-and-their-soluble-forms-differ-in-the-knee-and-thumb-basal-osteoarthritic-joints
#5
Goncalo Barreto, Jerker Sandelin, Abdelhakim Salem, Dan C Nordström, Eero Waris
Background and purpose - Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be involved. We examined the relationship between Toll-like receptors (TLRs) and OA in cartilage from 2 joints differing in size and mechanical loading: the first carpometacarpal (CMC-I) and the knee. Patients and methods - Samples of human cartilage obtained from OA CMC-I and knee joints were immunostained for TLRs (1-9) and analyzed using histomorphometry and principal component analysis (PCA)...
January 17, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28090441/principal-component-analysis-t1%C3%AF-voxel-based-relaxometry-of-the-articular-cartilage-a-comparison-of-biochemical-patterns-in-osteoarthritis-and-anterior-cruciate-ligament-subjects
#6
Valentina Pedoia, Colin Russell, Allison Randolph, Xiaojuan Li, Sharmila Majumdar
BACKGROUND: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR)...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28029358/analysis-of-an-early-intervention-distal-femoral-resurfacing-implant-for-medial-osteoarthritis
#7
Miriam Chaudhary, Peter S Walker
A design concept was formulated for implants to treat medial osteoarthritis of the knee, using a metal plate resurfacing of the tibia plateau and a plastic bearing embedded in the distal end of the femur. A finite element analysis was carried out to determine whether a metal backing would be needed for the femoral component, and to what extent the stress and strain distribution in the trabecular bone surrounding the implant would match the normal intact condition. The CT scans from three knees scheduled for unicompartmental replacement were selected to generate computer models with variable bone densities in each element to cover a range of density patterns...
October 6, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27973527/the-nature-of-age-related-differences-in-knee-function-during-walking-implication-for-the-development-of-knee-osteoarthritis
#8
Katherine A Boyer, Thomas P Andriacchi
BACKGROUND: Changes in knee kinematics have been identified in the early stages of osteoarthritis (OA). However, there is a paucity of information on the nature of kinematic change that occur with aging prior to the development of OA, This study applied a robust statistical method (Principal Component Analysis) to test the hypothesis that coupling between primary (flexion) and secondary (anterior-posterior translation, internal-external rotation) joint motions in walking would differ for age groupings of healthy subjects...
2016: PloS One
https://www.readbyqxmd.com/read/27896800/principal-component-analysis-in-the-evaluation-of-osteoarthritis
#9
Stephanie E Calce, Helen K Kurki, Darlene A Weston, Lisa Gould
OBJECTIVES: The purpose of this study is to demonstrate advantages of principal component analysis (PCA) as a standardized procedure in the evaluation of osteoarthritis (OA) in a skeletal series to: (1) compute aggregate scores for joint complexes that accurately capture pathological expression, (2) reveal which variables describe the most sample variation in OA, (3) enable inter- and intra-sample comparison of results, and (4) formulate predictive models from component-based arthritic scores...
March 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27881929/rasch-analysis-of-the-western-ontario-osteoarthritis-of-the-shoulder-index-the-danish-version
#10
Sahar Moeini, Jeppe V Rasmussen, Tobias W Klausen, Stig Brorson
PURPOSE: The Western Ontario Osteoarthritis of the Shoulder (WOOS) index is a disease-specific, patient-reported, 19-question survey that measures the quality of life among patients with osteoarthritis (OA). The purpose of this study was to validate the Danish version of WOOS for OA and fractures (FRs) using modern test theory. PATIENTS AND METHODS: The study included 1,987 arthroplasties in 1,943 patients that were reported to the Danish Shoulder Arthroplasty Register between 2006 and 2011...
2016: Patient related Outcome Measures
https://www.readbyqxmd.com/read/27777643/the-overexpression-of-nalp3-inflammasome-in-knee-osteoarthritis-is-associated-with-synovial-membrane-prolidase-and-nadph-oxidase-2
#11
Denise Clavijo-Cornejo, Karina Martínez-Flores, Karina Silva-Luna, Gabriela Angélica Martínez-Nava, Javier Fernández-Torres, Yessica Zamudio-Cuevas, Mónica Guadalupe Santamaría-Olmedo, Julio Granados-Montiel, Carlos Pineda, Alberto López-Reyes
Osteoarthritis is characterized by the presence of proinflammatory cytokines and reactive oxygen species. We aimed to clarify the role of prooxidant enzyme content at the synovial membrane level and how it correlates with the inflammatory process in patients with knee osteoarthritis (KOA). In synovial membranes from KOA patients and control group, we analyzed the protein content of prooxidant enzymes such as Nox2, xanthine oxidase (XO), and prolidase as well as the proinflammatory NALP3. Results show that protein content of prolidase and Nox2 increased 4...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27542282/next-generation-sequencing-identifies-articular-cartilage-and-subchondral-bone-mirnas-after-eswt-on-early-osteoarthritis-knee
#12
Jai-Hong Cheng, Ching-Jen Wang, Shi-Hao Su, Chien-Yiu Huang, Shan-Ling Hsu
Extracorporeal shockwave therapy (ESWT) has shown chondroprotective effects on the initiation of the osteoarthritis (OA) changes of the rat knee. This study evaluated 69 significant expressed profiles of microRNA (miRNA) in the articular cartilage and subchondral bone after ESWT. There were 118 target genes identified for miRNAs of interest in articular cartilage and 214 target genes in subchondral bone by next generation sequencing (NGS). In principal component analysis (PCA), the relationships of miRNA expression in bone and cartilage were improved after ESWT...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27509479/mild-leg-length-discrepancy-affects-lower-limbs-pelvis-and-trunk-biomechanics-of-individuals-with-knee-osteoarthritis-during-gait
#13
Renan A Resende, Renata N Kirkwood, Kevin J Deluzio, Amy M Morton, Sérgio T Fonseca
BACKGROUND: Leg length discrepancy greater than 1cm increases odds of progressive knee osteoarthritis in the shorter limb. METHODS: Biomechanical data of 15 knee osteoarthritis participants were collected while they walked under two conditions: (1) control - wearing thick sandals; (2) short limb - wearing a thin sandal on the osteoarthritic limb and a thick sandal on the contralateral limb. The thick and thin sandals had 1.45cm of thickness difference. The knee osteoarthritis limb was analyzed for both conditions...
October 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27378743/the-synovial-microenvironment-of-osteoarthritic-joints-alters-rna-seq-expression-profiles-of-human-primary-articular-chondrocytes
#14
Eric A Lewallen, Carolina A Bonin, Xin Li, Jay Smith, Marcel Karperien, A Noelle Larson, David G Lewallen, Simon M Cool, Jennifer J Westendorf, Aaron J Krych, Alexey A Leontovich, Hee-Jeong Im, Andre J van Wijnen
Osteoarthritis (OA) is a disabling degenerative joint disease that prompts pain and has limited treatment options. To permit early diagnosis and treatment of OA, a high resolution mechanistic understanding of human chondrocytes in normal and diseased states is necessary. In this study, we assessed the biological effects of OA-related changes in the synovial microenvironment on chondrocytes embedded within anatomically intact cartilage from joints with different pathological grades by next generation RNA-sequencing (RNA-seq)...
October 15, 2016: Gene
https://www.readbyqxmd.com/read/27374878/differential-effects-of-altered-patterns-of-movement-and-strain-on-joint-cell-behaviour-and-skeletal-morphogenesis
#15
L H Brunt, R E H Skinner, K A Roddy, N M Araujo, E J Rayfield, C L Hammond
OBJECTIVE: There is increasing evidence that joint shape is a potent predictor of osteoarthritis (OA) risk; yet the cellular events underpinning joint morphogenesis remain unclear. We sought to develop a genetically tractable animal model to study the events controlling joint morphogenesis. DESIGN: Zebrafish larvae were subjected to periods of flaccid paralysis, rigid paralysis or hyperactivity. Immunohistochemistry and transgenic reporters were used to monitor changes to muscle and cartilage...
November 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27255606/can-a-linear-combination-of-gait-principal-component-vectors-identify-hip-oa-stages
#16
Marzieh M Ardestani, Markus A Wimmer
Hip osteoarthritis (OA) has been shown to affect gait patterns of lower extremities. However, until now, no specific identifying gait characteristics for the various disease stages of hip OA have emerged. The present study addresses the following questions: (1) does a vector-based principal component analysis (PCA) discriminate between various disease stages? And, is this analysis more robust than using discrete gait variables? (2) Does the elimination of differences in walking speed affect the discriminatory robustness of a vector-based PCA? De-identified data sets of forty-five unilateral hip OA patients with varying disease stages and twenty-three age-matched, healthy control subjects were obtained from an available repository...
July 5, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27133762/gc-tof-ms-based-metabolomic-profiling-in-cultured-fibroblast-like-synoviocytes-from-rheumatoid-arthritis
#17
Joong Kyong Ahn, Sooah Kim, Jiwon Hwang, Jungyeon Kim, Kyoung Heon Kim, Hoon-Suk Cha
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and hyperplasia. Fibroblast-like synoviocytes (FLS) in RA exhibit a tumor cell-like aggressive phenotype. Thus, gas chromatography/time-of-flight-mass spectrometry (GC/TOF-MS) was employed to identify the characteristic metabolic profiling of RA FLS. METHODS: Metabolite profiling of RA FLS and osteoarthritis (OA) FLS was performed using GC/TOF-MS in conjunction with statistical analyses...
December 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27072641/gender-differences-in-gait-kinematics-for-patients-with-knee-osteoarthritis
#18
Angkoon Phinyomark, Sean T Osis, Blayne A Hettinga, Dylan Kobsar, Reed Ferber
BACKGROUND: Females have a two-fold risk of developing knee osteoarthritis (OA) as compared to their male counterparts and atypical walking gait biomechanics are also considered a factor in the aetiology of knee OA. However, few studies have investigated sex-related differences in walking mechanics for patients with knee OA and of those, conflicting results have been reported. Therefore, this study was designed to examine the differences in gait kinematics (1) between male and female subjects with and without knee OA and (2) between healthy gender-matched subjects as compared with their OA counterparts...
April 12, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27060435/ipsilateral-and-contralateral-foot-pronation-affect-lower-limb-and-trunk-biomechanics-of-individuals-with-knee-osteoarthritis-during-gait
#19
Renan A Resende, Renata N Kirkwood, Kevin J Deluzio, Elizabeth A Hassan, Sérgio T Fonseca
BACKGROUND: Lateral wedges have been suggested for the treatment of individuals with knee osteoarthritis, but it may have undesirable effects on the biomechanics of gait through increased foot pronation. This study investigated the effects of increased unilateral foot pronation on the biomechanics of individuals with knee osteoarthritis during gait. METHODS: Biomechanical data of twenty individuals with knee osteoarthritis were collected while they walked in three conditions: i) flat sandals; ii) wedged sandal on the knee osteoarthritis limb and flat sandal on the healthy limb; and iii) flat sandal on the osteoarthritis and wedged sandal on the healthy limb...
2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27020532/impairment-in-the-activities-of-daily-living-in-older-adults-with-and-without-osteoporosis-osteoarthritis-and-chronic-back-pain-a-secondary-analysis-of-population-based-health-survey-data
#20
Tanja Alexandra Stamm, Karin Pieber, Richard Crevenna, Thomas Ernst Dorner
BACKGROUND: Independence in performing activities of daily living (ADLs) is a central aspect of functioning. Older adults frequently experience impairments and limitations in functioning in various life areas. The aim of this survey was to explore the limitations in the ADLs in older adults in a population-based survey in Austria. METHOD: A population-based cross-sectional study in 3097 subjects aged ≥65 years who were included in the Austrian health interview survey was performed...
March 28, 2016: BMC Musculoskeletal Disorders
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