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principal component analysis osteoarthritis

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https://www.readbyqxmd.com/read/27896800/principal-component-analysis-in-the-evaluation-of-osteoarthritis
#1
Stephanie E Calce, Helen K Kurki, Darlene A Weston, Lisa Gould
OBJECTIVES: The purpose of this study is to demonstrate advantages of principal component analysis (PCA) as a standardized procedure in the evaluation of osteoarthritis (OA) in a skeletal series to: (1) compute aggregate scores for joint complexes that accurately capture pathological expression, (2) reveal which variables describe the most sample variation in OA, (3) enable inter- and intra-sample comparison of results, and (4) formulate predictive models from component-based arthritic scores...
November 29, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27881929/rasch-analysis-of-the-western-ontario-osteoarthritis-of-the-shoulder-index-the-danish-version
#2
Sahar Moeini, Jeppe V Rasmussen, Tobias W Klausen, Stig Brorson
PURPOSE: The Western Ontario Osteoarthritis of the Shoulder (WOOS) index is a disease-specific, patient-reported, 19-question survey that measures the quality of life among patients with osteoarthritis (OA). The purpose of this study was to validate the Danish version of WOOS for OA and fractures (FRs) using modern test theory. PATIENTS AND METHODS: The study included 1,987 arthroplasties in 1,943 patients that were reported to the Danish Shoulder Arthroplasty Register between 2006 and 2011...
2016: Patient related Outcome Measures
https://www.readbyqxmd.com/read/27777643/the-overexpression-of-nalp3-inflammasome-in-knee-osteoarthritis-is-associated-with-synovial-membrane-prolidase-and-nadph-oxidase-2
#3
Denise Clavijo-Cornejo, Karina Martínez-Flores, Karina Silva-Luna, Gabriela Angélica Martínez-Nava, Javier Fernández-Torres, Yessica Zamudio-Cuevas, Mónica Guadalupe Santamaría-Olmedo, Julio Granados-Montiel, Carlos Pineda, Alberto López-Reyes
Osteoarthritis is characterized by the presence of proinflammatory cytokines and reactive oxygen species. We aimed to clarify the role of prooxidant enzyme content at the synovial membrane level and how it correlates with the inflammatory process in patients with knee osteoarthritis (KOA). In synovial membranes from KOA patients and control group, we analyzed the protein content of prooxidant enzymes such as Nox2, xanthine oxidase (XO), and prolidase as well as the proinflammatory NALP3. Results show that protein content of prolidase and Nox2 increased 4...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27542282/next-generation-sequencing-identifies-articular-cartilage-and-subchondral-bone-mirnas-after-eswt-on-early-osteoarthritis-knee
#4
Jai-Hong Cheng, Ching-Jen Wang, Shi-Hao Su, Chien-Yiu Huang, Shan-Ling Hsu
Extracorporeal shockwave therapy (ESWT) has shown chondroprotective effects on the initiation of the osteoarthritis (OA) changes of the rat knee. This study evaluated 69 significant expressed profiles of microRNA (miRNA) in the articular cartilage and subchondral bone after ESWT. There were 118 target genes identified for miRNAs of interest in articular cartilage and 214 target genes in subchondral bone by next generation sequencing (NGS). In principal component analysis (PCA), the relationships of miRNA expression in bone and cartilage were improved after ESWT...
August 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27509479/mild-leg-length-discrepancy-affects-lower-limbs-pelvis-and-trunk-biomechanics-of-individuals-with-knee-osteoarthritis-during-gait
#5
Renan A Resende, Renata N Kirkwood, Kevin J Deluzio, Amy M Morton, Sérgio T Fonseca
BACKGROUND: Leg length discrepancy greater than 1cm increases odds of progressive knee osteoarthritis in the shorter limb. METHODS: Biomechanical data of 15 knee osteoarthritis participants were collected while they walked under two conditions: (1) control - wearing thick sandals; (2) short limb - wearing a thin sandal on the osteoarthritic limb and a thick sandal on the contralateral limb. The thick and thin sandals had 1.45cm of thickness difference. The knee osteoarthritis limb was analyzed for both conditions...
October 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27378743/the-synovial-microenvironment-of-osteoarthritic-joints-alters-rna-seq-expression-profiles-of-human-primary-articular-chondrocytes
#6
Eric A Lewallen, Carolina A Bonin, Xin Li, Jay Smith, Marcel Karperien, A Noelle Larson, David G Lewallen, Simon M Cool, Jennifer J Westendorf, Aaron J Krych, Alexey A Leontovich, Hee-Jeong Im, Andre J van Wijnen
Osteoarthritis (OA) is a disabling degenerative joint disease that prompts pain and has limited treatment options. To permit early diagnosis and treatment of OA, a high resolution mechanistic understanding of human chondrocytes in normal and diseased states is necessary. In this study, we assessed the biological effects of OA-related changes in the synovial microenvironment on chondrocytes embedded within anatomically intact cartilage from joints with different pathological grades by next generation RNA-sequencing (RNA-seq)...
October 15, 2016: Gene
https://www.readbyqxmd.com/read/27374878/differential-effects-of-altered-patterns-of-movement-and-strain-on-joint-cell-behaviour-and-skeletal-morphogenesis
#7
Lucy H Brunt, Roderick E H Skinner, Karen A Roddy, Natalia M Araujo, Emily J Rayfield, Chrissy L Hammond
OBJECTIVE: There is increasing evidence that joint shape is a potent predictor of osteoarthritis risk; yet the cellular events underpinning joint morphogenesis remain unclear. We sought to develop a genetically tractable animal model to study the events controlling joint morphogenesis. DESIGN: Zebrafish larvae were subjected to periods of flaccid paralysis, rigid paralysis or hyperactivity. Immunohistochemistry and transgenic reporters were used to monitor changes to muscle and cartilage...
June 29, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27255606/can-a-linear-combination-of-gait-principal-component-vectors-identify-hip-oa-stages
#8
Marzieh M Ardestani, Markus A Wimmer
Hip osteoarthritis (OA) has been shown to affect gait patterns of lower extremities. However, until now, no specific identifying gait characteristics for the various disease stages of hip OA have emerged. The present study addresses the following questions: (1) does a vector-based principal component analysis (PCA) discriminate between various disease stages? And, is this analysis more robust than using discrete gait variables? (2) Does the elimination of differences in walking speed affect the discriminatory robustness of a vector-based PCA? De-identified data sets of forty-five unilateral hip OA patients with varying disease stages and twenty-three age-matched, healthy control subjects were obtained from an available repository...
July 5, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27133762/gc-tof-ms-based-metabolomic-profiling-in-cultured-fibroblast-like-synoviocytes-from-rheumatoid-arthritis
#9
Joong Kyong Ahn, Sooah Kim, Jiwon Hwang, Jungyeon Kim, Kyoung Heon Kim, Hoon-Suk Cha
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and hyperplasia. Fibroblast-like synoviocytes (FLS) in RA exhibit a tumor cell-like aggressive phenotype. Thus, gas chromatography/time-of-flight-mass spectrometry (GC/TOF-MS) was employed to identify the characteristic metabolic profiling of RA FLS. METHODS: Metabolite profiling of RA FLS and osteoarthritis (OA) FLS was performed using GC/TOF-MS in conjunction with statistical analyses...
April 25, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27072641/gender-differences-in-gait-kinematics-for-patients-with-knee-osteoarthritis
#10
Angkoon Phinyomark, Sean T Osis, Blayne A Hettinga, Dylan Kobsar, Reed Ferber
BACKGROUND: Females have a two-fold risk of developing knee osteoarthritis (OA) as compared to their male counterparts and atypical walking gait biomechanics are also considered a factor in the aetiology of knee OA. However, few studies have investigated sex-related differences in walking mechanics for patients with knee OA and of those, conflicting results have been reported. Therefore, this study was designed to examine the differences in gait kinematics (1) between male and female subjects with and without knee OA and (2) between healthy gender-matched subjects as compared with their OA counterparts...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27060435/ipsilateral-and-contralateral-foot-pronation-affect-lower-limb-and-trunk-biomechanics-of-individuals-with-knee-osteoarthritis-during-gait
#11
Renan A Resende, Renata N Kirkwood, Kevin J Deluzio, Elizabeth A Hassan, Sérgio T Fonseca
BACKGROUND: Lateral wedges have been suggested for the treatment of individuals with knee osteoarthritis, but it may have undesirable effects on the biomechanics of gait through increased foot pronation. This study investigated the effects of increased unilateral foot pronation on the biomechanics of individuals with knee osteoarthritis during gait. METHODS: Biomechanical data of twenty individuals with knee osteoarthritis were collected while they walked in three conditions: i) flat sandals; ii) wedged sandal on the knee osteoarthritis limb and flat sandal on the healthy limb; and iii) flat sandal on the osteoarthritis and wedged sandal on the healthy limb...
May 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27020532/impairment-in-the-activities-of-daily-living-in-older-adults-with-and-without-osteoporosis-osteoarthritis-and-chronic-back-pain-a-secondary-analysis-of-population-based-health-survey-data
#12
Tanja Alexandra Stamm, Karin Pieber, Richard Crevenna, Thomas Ernst Dorner
BACKGROUND: Independence in performing activities of daily living (ADLs) is a central aspect of functioning. Older adults frequently experience impairments and limitations in functioning in various life areas. The aim of this survey was to explore the limitations in the ADLs in older adults in a population-based survey in Austria. METHOD: A population-based cross-sectional study in 3097 subjects aged ≥65 years who were included in the Austrian health interview survey was performed...
March 28, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26873657/development-and-psychometric-testing-of-a-scale-for-evaluating-self-management-needs-of-knee-osteoarthritis-smnkoa-in-taiwan
#13
Mei-Hua Kao, Yun-Fang Tsai
Self-management of osteoarthritis (OA) of the knee is important for treating this chronic disease. This study developed and psychometrically tested a new instrument for measuring adult patients' self-management needs of knee osteoarthritis (SMNKOA). The theoretical framework of self-care guided the development of the 35-item SMNKOA scale. Participants (N = 372) were purposively sampled from orthopedic clinics at medical centers in Taiwan. The content validity index was 0.83. Principal components analysis identified a three-factor solution, accounting for 53...
February 12, 2016: Clinical Nursing Research
https://www.readbyqxmd.com/read/26714257/comparison-of-gait-characteristics-between-patients-with-nontraumatic-and-posttraumatic-medial-knee-osteoarthritis
#14
Shawn M Robbins, Trevor B Birmingham, Ian C Jones, Emily L Sischek, Mareike Dietzsch, J Robert Giffin
OBJECTIVE: To compare knee kinematics and kinetics during walking in patients with posttraumatic versus nontraumatic medial compartment knee osteoarthritis (OA). METHODS: Participants with medial compartment knee OA were classified as nontraumatic (n = 122) or posttraumatic (n = 93) based on evidence of previous anterior cruciate ligament tear, confirmed arthroscopically. Kellgren/Lawrence severity scores and mechanical axis angle (MAA) were determined from radiographs...
September 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26620089/novel-statistical-methodology-reveals-that-hip-shape-is-associated-with-incident-radiographic-hip-osteoarthritis-among-african-american-women
#15
H An, J S Marron, T A Schwartz, J B Renner, F Liu, J A Lynch, N E Lane, J M Jordan, A E Nelson
INTRODUCTION: Hip shape is a risk factor for the development of hip osteoarthritis (OA), and current methods to assess hip shape from radiographs are limited; therefore this study explored current and novel methods to assess hip shape. METHODS: Data from a prior case-control study nested in the Johnston County OA Project were used, including 382 hips (from 342 individuals). Hips were classified by radiographic hip OA (RHOA) status as RHOA cases (baseline Kellgren Lawrence grade [KLG] 0 or 1, follow-up [mean 6 years] KLG ≥ 2) or controls (KLG = 0 or 1 at both baseline and follow-up)...
April 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/26559464/obesity-is-associated-with-prolonged-activity-of-the-quadriceps-and-gastrocnemii-during-gait
#16
P Amiri, C L Hubley-Kozey, S C Landry, W D Stanish, J L Astephen Wilson
PURPOSE: To examine the effect of obesity and its potential interaction with knee OA presence on the electromyography patterns of the major knee joint periarticular muscles during walking. SCOPE: One hundred and eighteen asymptomatic adults and 177 adults with moderate knee osteoarthritis were subdivided into categories of healthy weight (n = 77; 20 kg/m(2) < BMI < 25 kg/m(2)), overweight (n = 117; 25 kg/m(2) ⩽ BMI < 30 kg/m(2)), and obese (n = 101; BMI ⩾ 30 kg/m(2) based on their body mass index (BMI)...
December 2015: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/26556390/validity-and-reliability-of-the-dutch-version-of-the-international-hip-outcome-tool-ihot-12nl-in-patients-with-disorders-of-the-hip
#17
Martin Stevens, Inge van den Akker-Scheek, Bas ten Have, Marco Adema, Hilde Giezen, Inge H F Reininga
STUDY DESIGN: Clinical measurement. OBJECTIVES: To translate and culturally adapt the international Hip Outcome Tool (iHOT-12) into Dutch and to determine its validity and reliability. BACKGROUND: The iHOT-12 for measuring health-related quality of life and physical functioning in younger, active patients with hip pathology is available in English and Swedish. The tool is scored on a 0-to-100-point scale, with higher scores reflecting better function...
December 2015: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/26555194/mirna-profiling-of-whole-trabecular-bone-identification-of-osteoporosis-related-changes-in-mirnas-in-human-hip-bones
#18
Laura De-Ugarte, Guy Yoskovitz, Susana Balcells, Robert Güerri-Fernández, Santos Martinez-Diaz, Leonardo Mellibovsky, Roser Urreizti, Xavier Nogués, Daniel Grinberg, Natalia García-Giralt, Adolfo Díez-Pérez
BACKGROUND: MicroRNAs (miRNAs) are important regulators of gene expression, with documented roles in bone metabolism and osteoporosis, suggesting potential therapeutic targets. Our aim was to identify miRNAs differentially expressed in fractured vs nonfractured bones. Additionally, we performed a miRNA profiling of primary osteoblasts to assess the origin of these differentially expressed miRNAs. METHODS: Total RNA was extracted from (a) fresh femoral neck trabecular bone from women undergoing hip replacement due to either osteoporotic fracture (OP group, n = 6) or osteoarthritis in the absence of osteoporosis (Control group, n = 6), matching the two groups by age and body mass index, and (b) primary osteoblasts obtained from knee replacement due to osteoarthritis (n = 4)...
2015: BMC Medical Genomics
https://www.readbyqxmd.com/read/26542484/hip-joint-motion-and-gluteal-muscle-activation-differences-between-healthy-controls-and-those-with-varying-degrees-of-hip-osteoarthritis-during-walking
#19
Derek J Rutherford, Janice Moreside, Ivan Wong
PURPOSE: Compare gluteal muscle activation patterns and three-dimensional hip joint movements among those with severe hip osteoarthritis (OA), moderate OA and a healthy group during walking. SCOPE: 20 individuals with severe OA, 20 with moderate OA and 20 healthy individuals were recruited. Three-dimensional hip motion and surface electromyograms from gluteus maximus and medius were collected during treadmill walking at a self-selected speed. Angular displacement characteristics were calculated for three-dimensional hip motions...
December 2015: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/26471854/quadriceps-strength-muscle-activation-failure-and-patient-reported-function-at-the-time-of-return-to-activity-in-patients-following-anterior-cruciate-ligament-reconstruction-a-cross-sectional-study
#20
Lindsey K Lepley, Riann M Palmieri-Smith
STUDY DESIGN: Cross-sectional. OBJECTIVES: To determine if quadriceps activation failure (QAF) moderates the relationship between quadriceps strength and physical function in individuals following anterior cruciate ligament (ACL) reconstruction. BACKGROUND: Quadriceps activation failure may impair the recovery of physical function after ACL reconstruction, given that QAF reduces strength and strength is related to physical function. Evidence of this relationship has been found in individuals with knee osteoarthritis, wherein patients with lower strength and greater QAF had lower levels of physical function...
December 2015: Journal of Orthopaedic and Sports Physical Therapy
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