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https://www.readbyqxmd.com/read/28319106/a-systematic-review-on-the-impact-of-diabetes-mellitus-on-the-ocular-surface
#1
REVIEW
K Co Shih, K S-L Lam, L Tong
Diabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28319002/hba1c-in-relation-to-incident-diabetes-and-diabetes-related-complications-in-non-diabetic-adults-at-baseline
#2
Patricia Anne Metcalf, Cam Kyle, Tim Kenealy, Rod T Jackson
AIMS: We compared the utility of glycated hemoglobin (HbA1c) and oral glucose tolerance (oGTT) in non-diabetic patients for identifying incident diabetes; all-cause mortality; cardiovascular disease (CVD) mortality; CVD, coronary heart disease (CHD), and ischemic stroke events; and diabetes microvascular complications. METHODS: Data from a New Zealand community setting were prospectively linked to hospitalization, mortality, pharmaceutical and laboratory test results data...
February 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28303846/heart-rate-variability-in-patients-with-acute-ischemic-stroke-at-different-stages-of-renal-dysfunction-a-cross-sectional-observational-study
#3
Lin Wei, Wen-Bo Zhao, Huan-Wen Ye, Yan-Hua Chen, Xiao-Pei Zhang, Yan Huang, Ye-Feng Cai, Quan-Fu Chen, Su-Yue Pan
BACKGROUND: Renal function is associated with mortality and functional disabilities in stroke patients, and impaired autonomic function is common in stroke, but little is known regarding its effects on stroke patients with renal dysfunction. This study sought to evaluate the association between autonomic function and stroke in patients with renal dysfunction. METHODS: This study comprised 232 patients with acute ischemic stroke consecutively enrolled from February 2013 to November 2014 at Guangdong Provincial Hospital of Chinese Medicine in China...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28296884/increased-von-willebrand-factor-decreased-adamts13-and-thrombocytopenia-in-melioidosis
#4
Emma Birnie, Gavin C K W Koh, Ester C Löwenberg, Joost C M Meijers, Rapeephan R Maude, Nicholas P J Day, Sharon J Peacock, Tom van der Poll, W Joost Wiersinga
BACKGROUND: Melioidosis, caused by bioterror treat agent Burkholderia pseudomallei, is an important cause of community-acquired Gram-negative sepsis in Southeast Asia and Northern Australia. New insights into the pathogenesis of melioidosis may help improve treatment and decrease mortality rates from this dreadful disease. We hypothesized that changes in Von Willebrand factor (VWF) function should occur in melioidosis, based on the presence of endothelial stimulation by endotoxin, pro-inflammatory cytokines and thrombin in melioidosis, and investigated whether this impacted on outcome...
March 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28273040/the-cost-of-diabetes-in-canada-over-10-years-applying-attributable-health-care-costs-to-a-diabetes-incidence-prediction-model
#5
Anja Bilandzic, Laura Rosella
INTRODUCTION: Our objective was to estimate the future direct health care costs due to diabetes for a 10-year period in Canada using national survey data, a validated diabetes risk prediction tool and individual-level attributable cost estimates. METHODS: We used the Diabetes Population Risk Tool to predict the number of new diabetes cases in those aged 20 years and above over a 10-year period (to 2022), using 2011 and 2012 Canadian Community Health Survey data...
February 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28255010/heart-failure-incidence-and-mortality-in-the-southern-community-cohort-study
#6
Elvis A Akwo, Edmond K Kabagambe, Thomas J Wang, Frank E Harrell, William J Blot, Michael Mumma, Deepak K Gupta, Loren Lipworth
BACKGROUND: There is a paucity of data on heart failure (HF) incidence among low-income and minority populations. Our objective was to investigate HF incidence and post-HF survival by race and sex among low-income adults in the southeastern United States. METHODS AND RESULTS: Participants were 27 078 white and black men and women enrolled during 2002 to 2009 in the SCCS (Southern Community Cohort Study) who had no history of HF and were receiving Centers for Medicare and Medicaid Services...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28216110/the-current-global-state-of-key-lifestyle-characteristics-health-and-economic-implications
#7
REVIEW
Ross Arena, Amy McNeil, Michael Sagner, Andrew P Hills
The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals, families and communities, placing an unsustainable burden on health systems. There is hope for the chronic disease crisis in that these conditions are largely preventable or can be delayed to much later in life through a timeless medicine, healthy living...
February 16, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28212629/cardiometabolic-risk-in-a-population-of-older-adults-with-multiple-co-morbidities-in-rural-south-africa-the-haalsi-health-and-aging-in-africa-longitudinal-studies-of-indepth-communities-study
#8
Thomas A Gaziano, Shafika Abrahams-Gessel, F Xavier Gomez-Olive, Alisha Wade, Nigel J Crowther, Sartaj Alam, Jennifer Manne-Goehler, Chodziwadziwa W Kabudula, Ryan Wagner, Julia Rohr, Livia Montana, Kathleen Kahn, Till W Bärnighausen, Lisa F Berkman, Stephen Tollman
BACKGROUND: A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults...
February 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28196524/financial-barriers-and-adverse-clinical-outcomes-among-patients-with-cardiovascular-related-chronic-diseases-a-cohort-study
#9
David J T Campbell, Braden J Manns, Robert G Weaver, Brenda R Hemmelgarn, Kathryn M King-Shier, Claudia Sanmartin
BACKGROUND: Some patients with cardiovascular-related chronic diseases such as diabetes and heart disease report financial barriers to achieving optimal health. Previous surveys report that the perception of having a financial barrier is associated with self-reported adverse clinical outcomes. We sought to confirm these findings using linked survey and administrative data to determine, among patients with cardiovascular-related chronic diseases, if there is an association between perceived financial barriers and the outcomes of: (1) disease-related hospitalizations, (2) all-cause mortality and (3) inpatient healthcare costs...
February 15, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28176888/seasonality-risk-factors-and-burden-of-community-acquired-pneumonia-in-copd-patients-a-population-database-study-using-linked-health-care-records
#10
Nicholas P Williams, Ngaire A Coombs, Matthew J Johnson, Lynn K Josephs, Lucy A Rigge, Karl J Staples, Mike Thomas, Tom Ma Wilkinson
BACKGROUND: Community-acquired pneumonia (CAP) is more common in patients with COPD than in the adult general population, with studies of hospitalized CAP patients consistently reporting COPD as a frequent comorbidity. However, despite an increasing recognition of its importance, large studies evaluating the incidence patterns over time, risk factors and burden of CAP in COPD are currently lacking. METHODS: A retrospective observational study using a large UK-based database of linked primary and secondary care records was conducted...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28174193/age-specific-trends-in-incidence-mortality-and-comorbidities-of-heart-failure-in-denmark-1995-2012
#11
Mia N Christiansen, Lars Køber, Peter Weeke, Ramachandran S Vasan, Jørgen L Jeppesen, J Gustav Smith, Gunnar H Gislason, Christian Torp-Pedersen, Charlotte Andersson
BACKGROUND: -The cumulative burden and importance of cardiovascular risk factors have changed over the last decades. Specifically, obesity rates have increased among younger people, whereas cardiovascular health has improved in the elderly. Little is known regarding how these changes have impacted the incidence and the mortality rates of heart failure. Therefore, we aimed to investigate the age-specific trends in the incidence and 1-year mortality rates following a first time diagnosis of heart failure in Denmark between 1995 and 2012...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28167592/patient-characteristics-management-and-predictors-of-outcome-from-severe-community-onset-staphylococcal-sepsis-in-northeast-thailand-a-prospective-multicenter-study
#12
T Eoin West, Chanthiwa Wikraiphat, Sarunporn Tandhavanant, Pitchayanant Ariyaprasert, Pornpan Suntornsut, Shawna Okamoto, Weera Mahavanakul, Pramot Srisamang, Sunchai Phiphitaporn, Jirasak Anukunananchai, Ploenchan Chetchotisakd, Sharon J Peacock, Narisara Chantratita
Staphylococcus aureus infection is a persistent threat in resource-restricted settings in southeast Asia but informative data about this disease remain limited. We analyzed characteristics, management, and predictors of outcome in severely septic patients with community-onset S. aureus infection in northeast Thailand. We performed a prospective, multicenter observational cohort study of community-onset S. aureus sepsis in four referral hospitals recruiting patients at least 14 years of age admitted between March 2010 and December 2013...
February 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28164259/five-year-mortality-in-patients-treated-for-severe-community-acquired-pneumonia-a-retrospective-study
#13
H Lenz, G O Norby, V Dahl, T E Ranheim, R E Haagensen
BACKGROUND: The mortality rate in patients with severe community-acquired pneumonia (SCAP) is high. We investigated the 5-year mortality rate and causes of death in a patient population treated for SCAP in our intensive care unit (ICU), and compared the mortality rate in patients with or without chronic obstructive pulmonary disease (COPD) as comorbidity. METHODS: This retrospective study, which covers a period of 10 years, included patients aged > 18 years admitted to our ICU with SCAP as primary diagnosis and in need of mechanical ventilation for more than 24 h...
April 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28153648/cost-effectiveness-of-subsidizing-fruit-and-vegetable-purchases-through-the-supplemental-nutrition-assistance-program
#14
Sung Eun Choi, Hilary Seligman, Sanjay Basu
INTRODUCTION: A diet high in fruits and vegetables (FV) is associated with reduced risk of chronic disease. One strategy to incentivize FV consumption among low-income households is to make them more affordable through the Supplemental Nutrition Assistance Program (SNAP). This study aims to identify the cost effectiveness of subsidizing FV purchases among the one in seven Americans who participate in SNAP. METHODS: A cost-effectiveness analysis was conducted from a societal perspective to estimate lifetime costs and health gains associated with subsidizing FV purchases...
January 30, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28141970/a-large-community-outbreak-of-legionnaires-disease-associated-with-a-cooling-tower-in-new-york-city-2015
#15
Don Weiss, Christopher Boyd, Jennifer L Rakeman, Sharon K Greene, Robert Fitzhenry, Trevor McProud, Kimberlee Musser, Li Huang, John Kornblum, Elizabeth J Nazarian, Annie D Fine, Sarah L Braunstein, Daniel Kass, Keren Landman, Pascal Lapierre, Scott Hughes, Anthony Tran, Jill Taylor, Deborah Baker, Lucretia Jones, Laura Kornstein, Boning Liu, Rodolfo Perez, David E Lucero, Eric Peterson, Isaac Benowitz, Kristen F Lee, Stephanie Ngai, Mitch Stripling, Jay K Varma
OBJECTIVES: Infections caused by Legionella are the leading cause of waterborne disease outbreaks in the United States. We investigated a large outbreak of Legionnaires' disease in New York City in summer 2015 to characterize patients, risk factors for mortality, and environmental exposures. METHODS: We defined cases as patients with pneumonia and laboratory evidence of Legionella infection from July 2 through August 3, 2015, and with a history of residing in or visiting 1 of several South Bronx neighborhoods of New York City...
March 2017: Public Health Reports
https://www.readbyqxmd.com/read/28120286/adverse-perinatal-outcomes-and-postpartum-multi-systemic-dysregulation-adding-vitamin-d-deficiency-to-the-allostatic-load-index
#16
Eynav Elgavish Accortt, James Mirocha, Christine Dunkel Schetter, Calvin J Hobel
Background Allostatic load (AL) is an index of multi-system physiological "wear-and-tear," operationalizing emergent chronic disease risk and predicting morbidity and mortality. AL has been proposed as an organizing framework for studying pregnancy outcomes and additional AL biomarkers for the study of maternal health would be valuable. Objectives To test whether adverse perinatal outcomes are associated with postpartum AL and if including vitamin D deficiency (serum 25(OH)D < 20 ng/ml) as an additional marker of postpartum AL increases the association...
January 24, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28102890/handgrip-strength-in-old-and-very-old-adults-mood-cognition-function-and-mortality
#17
Jochanan Stessman, Yakir Rottenberg, Matan Fischer, Aliza Hammerman-Rozenberg, Jeremy M Jacobs
OBJECTIVES: To determine the trajectory of handgrip strength (HGS) from age 70 to 90 and its association with mood, cognition, functional status, and mortality. DESIGN: Prospective follow-up of an age-homogenous representative community-dwelling cohort (born 1920-21) in the Jerusalem Longitudinal Cohort Study (1990-2015). SETTING: Home-based assessment. PARTICIPANTS: Subjects aged 70 (n = 327), 78 (n = 384), 85 (n = 1187), and 90 (n = 406), examined in 1990, 1998, 2005, and 2010, respectively...
January 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28100465/prevalence-of-masked-hypertension-among-us-adults-with-nonelevated-clinic-blood-pressure
#18
Y Claire Wang, Daichi Shimbo, Paul Muntner, Andrew E Moran, Lawrence R Krakoff, Joseph E Schwartz
Masked hypertension (MHT), defined as nonelevated blood pressure (BP) in the clinic setting and elevated BP assessed by ambulatory monitoring, is associated with increased risk of target organ damage, cardiovascular disease, and mortality. Currently, no estimate of MHT prevalence exists for the general US population. After pooling data from the Masked Hypertension Study (n = 811), a cross-sectional clinical investigation of systematic differences between clinic BP and ambulatory BP (ABP) in a community sample of employed adults in the New York City metropolitan area (2005-2012), and the National Health and Nutrition Examination Survey (NHANES; 2005-2010; n = 9,316), an ongoing nationally representative US survey, we used multiple imputation to impute ABP-defined hypertension status for NHANES participants and estimate MHT prevalence among the 139 million US adults with nonelevated clinic BP, no history of overt cardiovascular disease, and no use of antihypertensive medication...
January 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28089167/diabetic-self-care-practices-in-rural-mysuru-southern-karnataka-india-a-need-for-diabetes-self-management-educational-dsme-program
#19
K M Srinath, Madhu Basavegowda, Nandarula Sai Tharuni
CONTEXT: Diabetes and its complications are the leading cause of morbidity and mortality in the world. Self care has emerged as a crucial element in the management of diabetes and a key factor associated with the quality of diabetic care. AIMS: The purpose of the study was to assess the self care activities of patients with Type II diabetes mellitus in a rural area of Mysuru district. SETTINGS AND DESIGN: A community based cross sectional descriptive study was carried out among 400 diabetic patients in rural Mysore...
December 15, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28088662/metabolic-profiles-of-exudates-from-chronic-leg-ulcerations
#20
Adam Junka, Wojciech Wojtowicz, Adam Ząbek, Grzegorz Krasowski, Danuta Smutnicka, Barbara Bakalorz, Agnieszka Boruta, Mariusz Dziadas, Piotr Młynarz, Parish Paymon Sedghizadeh, Marzenna Bartoszewicz
Chronic leg ulceration is a disease usually associated with other comorbidities, and significantly reduces patient quality of life. Infected leg ulcers can lead to limb-threatening sequelae or mortality. Leg ulcerations are colonized by a number of microbes that are able to cause life-threating infections in susceptible patients. Wound exudate is a body fluid that collects metabolites from patient eukaryotic cells and from prokaryotic bacterial communities inhabiting the wound. This study aimed at identification of metabolites in exudates collected from chronic leg ulcers, and correlation of this metabolome with patient comorbidities and microbiological status of the wound...
January 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
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