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New Diagnosis of Chronic Pancreatitis

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https://www.readbyqxmd.com/read/28369140/serological-characteristics-of-autoimmune-pancreatitis-and-its-differential-diagnosis-from-pancreatic-cancer-by-using-a-combination-of-carbohydrate-antigen-19-9-globulin-eosinophils-and-hemoglobin
#1
Tianlian Yan, Yini Ke, Yi Chen, Chengfu Xu, Chaohui Yu, Youming Li
Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis, which may be misdiagnosed as pancreatic carcinoma. This study aims to verify new biomarkers for AIP and propose a serological pattern to differentiate AIP from pancreatic adenocarcinoma with routinely performed tests. In this study, data of serum samples were collected and compared between 25 patients with AIP and 100 patients with pancreatic carcinoma. Receiver operating characteristic analysis and logistic regression was performed to evaluate the diagnostic effect of serum parameters in differentiating AIP from pancreatic carcinoma alone or in combination...
2017: PloS One
https://www.readbyqxmd.com/read/28217237/-caught-by-the-eye-of-sound-epigastric-swelling-due-to-xiphisternal-tuberculosis
#2
Shabnam Bhandari Grover, Sumit Arora, Amit Kumar, Hemal Grover, Amit Katyan, Deepthi Mohan Nair
BACKGROUND: Common causes of an epigastric mass include hepatomegaly, pancreatic pseudocyst and epigastric hernia, less common causes being carcinoma of the stomach or pancreas, whereas diseases of the sternum presenting as an epigastric swelling is extremely uncommon. We report a case of tubercular infection of the sternum located in the xiphoid process resulting in its presentation as an epigastric swelling. CASE REPORT: A 30-year-old immunocompetent woman with complaints of an epigastric swelling and undocumented pyrexia for four months was referred for sonographic evaluation with a clinical suspicion of an incompletely treated liver abscess...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28213644/circulating-micrornas-and-diabetes-mellitus-a-novel-tool-for-disease-prediction-diagnosis-and-staging
#3
REVIEW
G Sebastiani, L Nigi, G E Grieco, F Mancarella, G Ventriglia, F Dotta
Diabetes is a complex, multifactorial group of metabolic diseases characterized by chronic hyperglycaemia due to pancreatic beta-cell dysfunction and/or loss. It is characterized by an asymptomatic and highly variable prodromic phase, which renders diabetes mellitus difficult to be predicted with sufficient accuracy. Despite several efforts in the identification and standardization of newly trustable. Biomarkers able to predict and follow-up diabetes and to specifically subtype its different forms, few of them have proven of clinical utility...
February 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28207725/ethnic-and-geographic-variations-in-the-incidence-of-pancreatitis-and-post-pancreatitis-diabetes-mellitus-in-new-zealand-a-nationwide-population-based-study
#4
Sayali A Pendharkar, Juby Mathew, Jinfeng Zhao, John A Windsor, Daniel J Exeter, Maxim S Petrov
AIM: To determine the incidence of acute pancreatitis (AP), chronic pancreatitis (CP), and post-pancreatitis diabetes mellitus (DP) in New Zealand, and the effect of ethnic and geographic variations. METHODS: Data were collected from all district health boards in New Zealand by the Ministry of Health (Manatū Hauora). Diagnosis of AP, CP and DP was determined by the International Classification of Diseases-10 codes. Incidence rates per 100,000 population per year were calculated using incident AP, CP and DP cases as the numerator, and the adult resident population of New Zealand as the denominator...
February 17, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28065243/autoimmune-pancreatitis-typing-diagnosis-and-treatment
#5
Yi-Xiao Zhao, Hong Lü
Autoimmune pancreatitis (AIP),a special type of chronic pancreatitis,is autoimmune-mediated and can be accompanied by swelling of the pancreas and irregular stenosis of the pancreatic duct. The main pathological features are fibrosis of pancreatic duct with IgG4-positive lymphoplasmacytic infiltration. Different typing methods of AIP can have differerent disease conditions. This paper reviews the history,clinical presentation,diagnostic criteria,and treatment of different AIP types to provide a new basis for the diagnosis and treatment...
December 20, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28027898/lower-plasma-levels-of-glucose-dependent-insulinotropic-peptide-gip-and-pancreatic-polypeptide-pp-in-patients-with-ductal-adenocarcinoma-of-the-pancreas-and-their-relation-to-the-presence-of-impaired-glucoregulation-and-weight-loss
#6
Jan Škrha, Petr Bušek, Jana Uhrová, Petr Hrabal, Klára Kmochová, Martin Laclav, Bohuš Bunganič, Přemysl Frič
BACKGROUND: The changes in gastrointestinal hormones associated with pancreatic ductal adenocarcinoma (PDAC) in patients with impaired glucoregulation have yet to be evaluated. The aim of this study was to determine plasma concentrations of selected gastrointestinal hormones in PDAC patients with and without diabetes and to compare them with levels found in Type 2 diabetic patients without cancer. METHODS: In this study we examined plasma concentrations of glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide 1 (GLP-1), pancreatic polypeptide (PP), peptide YY (PYY) and neuropeptide Y (NPY), and cytokines leptin and adiponectin in 94 patients with histologically confirmed PDAC...
December 15, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27888869/latest-advances-in-chronic-pancreatitis
#7
J Enrique Domínguez-Muñoz
This article summarizes some of the recent and clinically relevant advances in chronic pancreatitis. These advances mainly concern the definition of the disease, the etiological diagnosis of idiopathic disease, the correlation between fibrosis degree and pancreatic secretion in the early stages of chronic pancreatitis, the treatment of the disease and of pain, the clinical relevance of pancreatic exocrine insufficiency, and the diagnosis of autoimmune pancreatitis. A new mechanistic definition of chronic pancreatitis has been proposed...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27826137/imaging-in-pancreatic-disease
#8
REVIEW
Julien Dimastromatteo, Teresa Brentnall, Kimberly A Kelly
Pancreatic diseases, chronic pancreatitis, pancreatic cancer and diabetes mellitus, taken together, occur in >10% of the world population. Pancreatic diseases, as with other diseases, benefit from early intervention and appropriate diagnosis. Although imaging technologies have given clinicians an unprecedented toolbox to aid in clinical decision-making, advances in these technologies and development of molecular-based diagnostic tools could enable physicians to identify diseases at an even earlier stage and, thereby, improve patient outcomes...
February 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27709245/cystic-fibrosis-a-clinical-view
#9
REVIEW
Carlo Castellani, Baroukh M Assael
Cystic fibrosis (CF), a monogenic disease caused by mutations in the CFTR gene on chromosome 7, is complex and greatly variable in clinical expression. Airways, pancreas, male genital system, intestine, liver, bone, and kidney are involved. The lack of CFTR or its impaired function causes fat malabsorption and chronic pulmonary infections leading to bronchiectasis and progressive lung damage. Previously considered lethal in infancy and childhood, CF has now attained median survivals of 50 years of age, mainly thanks to the early diagnosis through neonatal screening, recognition of mild forms, and an aggressive therapeutic attitude...
January 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27698546/insights-from-lncrnas-profiling-of-min6-beta-cells-undergoing-inflammation
#10
Chuntao Sun, Lihua Xue, Ziyang Zhu, Fan Zhang, Ruixue Yang, Xuewen Yuan, Zhanjun Jia, Qianqi Liu
Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by chronic and progressive apoptotic destruction of pancreatic beta cells. During the initial phases of T1DM, cytokines and other inflammatory mediators released by immune cells progressively infiltrate islet cells, induce alterations in gene expression, provoke functional impairment, and ultimately lead to apoptosis. Long noncoding RNAs (lncRNAs) are a new important class of pervasive genes that have a variety of biological functions and play key roles in many diseases...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27555793/hereditary-pancreatitis-current-perspectives
#11
REVIEW
Kara L Raphael, Field F Willingham
Hereditary pancreatitis (HP) is a rare cause of acute, recurrent acute, and chronic pancreatitis. It may present similarly to other causes of acute and chronic pancreatitis, and often there has been a protracted evaluation prior to the diagnosis of HP. Since it was first described in 1952, multiple genetic defects that affect the action of digestive enzymes in the pancreas have been implicated. The most common mutations involve the PRSS1, CFTR, SPINK1, and CTRC genes. New mutations in these genes and previously unrecognized mutations in other genes are being discovered due to the increasing use of next-generation genomic sequencing...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27554380/new-steps-of-elastography-for-the-diagnosis-of-chronic-pancreatitis
#12
Julio Iglesias-García
Editorial on the role of ultrasound guided elastography for the diagnosis of chronic pancreatitis.
August 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27466796/igg4-related-disease-in-organs-other-than-the-hepatobiliary-pancreatic-system
#13
Motohisa Yamamoto, Hiroki Takahashi
Immunoglobulin G4-related disease (IgG4-RD) is a new disease entity that was established in this century. It is a systemic and chronic inflammatory disorder. Autoimmune pancreatitis is a representative condition, but there is clearly involvement from other organs, including the kidneys, the retroperitoneal cavity, the lungs, and the thyroid, lacrimal, salivary, pituitary, and prostate glands. To aid in the resolution of the numerous issues related to IgG4-RD, the authors established a registry system of patients in multicenter institutes with IgG4-RD-the SMART registry...
August 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27428805/surgery-for-pancreatic-disease
#14
Daniel Hartmann, Benedikt Kaufmann, Helmut Friess
PURPOSE OF REVIEW: Surgery for pancreatic diseases is one of the most studied fields in general surgery and continues to evolve. This review focuses on recent advances in pancreatic surgery and summarizes the published research. RECENT FINDINGS: Surgery for pancreatic diseases is an evolving field with a wide range of innovations. Especially, contributions by high-volume pancreas centers have greatly improved outcomes in pancreatic surgery. In chronic pancreatitis, recent studies demonstrate that early surgical treatment should be favored over repeated endoscopic interventions, and local organ-preserving resection techniques should be preferred over classic Whipple resection...
July 15, 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27411434/insulitis-in-the-pathogenesis-of-type-1-diabetes
#15
REVIEW
Alberto Pugliese
Type 1 diabetes (T1D) is a chronic autoimmune disease in which autoreactive T-cells and inflammation cause severe loss of pancreatic beta cells. Insulitis, the pathologic hallmark of T1D, is an inflammatory lesion consisting of immune cell infiltrates around and within the islets. New research initiatives and methodologies are advancing our understanding of pancreas pathology. Studies have revealed the predominant cellular types that infiltrate the islets, novel molecular aspects associated with insulitis, and the coexistence of additional pathological abnormalities...
July 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27271825/hybrid-kappa-lambda-antibody-is-a-new-serological-marker-to-diagnose-autoimmune-pancreatitis-and-differentiate-it-from-pancreatic-cancer
#16
Mingju Hao, Wenli Li, Lang Yi, Songlin Yu, Gaowei Fan, Tian Lu, Xin Yang, Guojing Wang, Dong Zhang, Jiansheng Ding, Kuo Zhang, Rui Zhang, Guigao Lin, Yanxi Han, Lunan Wang, Jinming Li
The only generally accepted serological marker currently used for the diagnosis of autoimmune pancreatitis (AIP) is IgG4. Our aim was mainly to determine whether hybrid κ\λ antibody can help to diagnose AIP and to differentiate it from pancreatic cancer. We established an enzyme-linked immunosorbent assay (ELISA) system to measure the levels of hybrid κ\λ antibodies in human sera. Sera were obtained from 338 patients, including 61 with AIP, 74 with pancreatic cancer, 50 with acute pancreatitis, 40 with ordinary chronic pancreatitis, 15 with miscellaneous pancreatic diseases, and 98 with normal pancreas...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27214660/new-endoscopic-ultrasonography-techniques-for-pancreaticobiliary-diseases
#17
REVIEW
Ken Kamata, Masayuki Kitano, Shunsuke Omoto, Kumpei Kadosaka, Takeshi Miyata, Kosuke Minaga, Kentaro Yamao, Hajime Imai, Masatoshi Kudo
Endoscopic ultrasonography (EUS) is widely used to evaluate pancreaticobiliary diseases, especially pancreatic masses. EUS has a good ability to detect pancreatic masses, but it is not sufficient for the differential diagnosis of various types of lesions. In order to address the limitations of EUS, new techniques have been developed to improve the characterization of the lesions detected by EUS. EUS-guided fine needle aspiration (EUS-FNA) has been used for diagnosing pancreatic tumors. In order to improve the histological diagnostic yield, a EUS-FNA needle with a core trap has recently been developed...
July 2016: Ultrasonography
https://www.readbyqxmd.com/read/27196450/increased-risk-of-acute-coronary-syndrome-in-patients-with-chronic-pancreatitis-a-nationwide-cohort-analysis
#18
Ming-Tse Hsu, Cheng-Li Lin, Wei-Sheng Chung
Chronic inflammation may promote development of coronary heart disease. Studies on the relationship between chronic pancreatitis (CP) and cardiovascular diseases are scant.We conducted a nationwide retrospective cohort study to determine the risk of acute coronary syndrome (ACS) in patients with CP.We randomly selected a comparison cohort of individuals without CP from the Taiwan National Health Insurance Research Database (N = 23.74 million) and frequency-matched them with patients with CP from 2000 to 2010 in a 1:4 ratio according to age, sex, and index year...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27186921/contrast-enhancement-and-elastography-in-endoscopic-ultrasound-an-update-of-clinical-applications-in-pancreatic-diseases
#19
REVIEW
Marta Serrani, Andrea Lisotti, Giancarlo Caletti, Pietro Fusaroli
It is well established that endoscopic ultrasound (EUS) is fundamental in the characterization of many diseases concerning different organs, i.e. pancreaticobiliary diseases, gastrointestinal pathologic conditions, and lymph nodes of unknown origin. It is also well known that many factors can hamper the accuracy of EUS, i.e. biliary stents, chronic pancreatitis, poor operator's expertise. These factors can also lead to suboptimal accuracy when cytological confirmation through EUS-fine needle aspiration (EUS-FNA) is indicated...
August 2016: Minerva Medica
https://www.readbyqxmd.com/read/27082563/chronic-pancreatitis-correlates-with-increased-risk-of-cerebrovascular-disease-a-retrospective-population-based-cohort-study-in-taiwan
#20
Tuck-Siu Wong, Kuan-Fu Liao, Chi-Ming Lin, Cheng-Li Lin, Wen-Chi Chen, Shih-Wei Lai
The aim of this study is to explore whether there is a relationship between chronic pancreatitis and cerebrovascular disease in Taiwan. Using the claims data of the Taiwan National Health Insurance Program, we identified 16,672 subjects aged 20 to 84 years with a new diagnosis of chronic pancreatitis from 2000 to 2010 as the chronic pancreatitis group. We randomly selected 65,877 subjects aged 20 to 84 years without chronic pancreatitis as the nonchronic pancreatitis group. Both groups were matched by sex, age, comorbidities, and the index year of diagnosing chronic pancreatitis...
April 2016: Medicine (Baltimore)
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