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https://www.readbyqxmd.com/read/29773978/effects-of-sevoflurane-exposure-during-mid-pregnancy-on-learning-and-memory-in-offspring-rats-beneficial-effects-of-maternal-exercise
#1
Ziyi Wu, Xingyue Li, Yi Zhang, Dongyi Tong, Lili Wang, Ping Zhao
Fetal exposure to general anesthetics may pose significant neurocognitive risks but methods to mitigate against these detrimental effects are still to be determined. We set out, therefore, to assess whether single or repeated in utero exposure to sevoflurane triggers long-term cognitive impairments in rat offspring. Since maternal exercise during pregnancy has been shown to improve cognition in offspring, we hypothesized that maternal treadmill exercise during pregnancy would protect against sevoflurane-induced neurotoxicity...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29768423/projecting-shifts-in-thermal-habitat-for-686-species-on-the-north-american-continental-shelf
#2
James W Morley, Rebecca L Selden, Robert J Latour, Thomas L Frölicher, Richard J Seagraves, Malin L Pinsky
Recent shifts in the geographic distribution of marine species have been linked to shifts in preferred thermal habitats. These shifts in distribution have already posed challenges for living marine resource management, and there is a strong need for projections of how species might be impacted by future changes in ocean temperatures during the 21st century. We modeled thermal habitat for 686 marine species in the Atlantic and Pacific oceans using long-term ecological survey data from the North American continental shelves...
2018: PloS One
https://www.readbyqxmd.com/read/29714645/application-of-prioritization-approaches-to-optimize-environmental-monitoring-and-testing-of-pharmaceuticals
#3
Emily E Burns, Laura J Carter, Jason Snape, Jane Thomas-Oates, Alistair B A Boxall
Pharmaceuticals are ubiquitous in the natural environment with concentrations expected to rise as human population increases. Environmental risk assessments are available for a small portion of pharmaceuticals in use, raising concerns over the potential risks posed by other drugs that have little or no data. With >1900 active pharmaceutical ingredients in use, it would be a major task to test all of the compounds with little or no data. Desk-based prioritization studies provide a potential solution by identifying those substances that are likely to pose the greatest risk to the environment and which, therefore, need to be considered a priority for further study...
May 1, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29702697/slamm-visual-monocular-slam-with-continuous-mapping-using-multiple-maps
#4
Hayyan Afeef Daoud, Aznul Qalid Md Sabri, Chu Kiong Loo, Ali Mohammed Mansoor
This paper presents the concept of Simultaneous Localization and Multi-Mapping (SLAMM). It is a system that ensures continuous mapping and information preservation despite failures in tracking due to corrupted frames or sensor's malfunction; making it suitable for real-world applications. It works with single or multiple robots. In a single robot scenario the algorithm generates a new map at the time of tracking failure, and later it merges maps at the event of loop closure. Similarly, maps generated from multiple robots are merged without prior knowledge of their relative poses; which makes this algorithm flexible...
2018: PloS One
https://www.readbyqxmd.com/read/29687766/identification-and-prevalence-of-rnd-family-multidrug-efflux-pump-oqxab-genes-in-enterococci-isolates-from-swine-manure-in-china
#5
Li Yuan, Ya-Jun Zhai, Hua Wu, Hua-Run Sun, Zhi-Pei He, Ya-Bin Wang, Yu-Shan Pan, Nan-Nan Kuang, Gong-Zheng Hu
PURPOSE: The resistance/nodulation/cell division (RND) family multidrug efflux pump, OqxAB, has been identified as one of the leading mechanisms of plasmid-mediated quinolone resistance and has become increasingly prevalent among Enterobacteriaceae in recent years. However, oqxAB genes have not yet been reported in Enterococcus isolates. The aim of the present study was to identify the oqxAB genes and investigate their prevalence among Enterococcus from swine manure in China. METHODOLOGY: The oqxAB genes were screened in 87 Enterococcus isolates by PCR...
April 23, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29667377/the-usefulness-of-determination-of-the-procalcitonin-pct-concentration-in-gbs-piositive-pregnant-womens-blood-serum-for-anticipations-of-infections-in-newborns
#6
Wojciech Cnota, Dominika Mucha, Jan Mucha
Group-B streptococci (GBS) are commensal bacteria of the human body. They may, however, pose a serious life hazard to pregnant women. During labour, newborns of GBS-positive mothers run the risk of infections that may eventually lead to severe complications, sepsis or even death. For this reason, it is very important to find new diagnostic markers that will enable fast and effective diagnostics and control of the disease process. The level of procalcitonin emerges as a promising diagnostic parameter. AIM. Analysis of the impact of the procalcitonin (PCT) level in GBS-positive pregnant women on the possibility of complications and infections in mothers and newborns MATERIAL AND METHODS...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29665483/absorption-of-arsenic-from-soil-and-water-by-two-chard-beta-vulgaris-l-varieties-a-potential-risk-to-human-health
#7
L M Yañez, J A Alfaro, G Bovi Mitre
The accumulation of arsenic (As) in vegetables poses a risk of contamination to humans via the food chain. Two chard (var. cicla and var. d'ampuis) crops were grown for 60 days in greenhouses on Aridisol soil, and irrigated with water from Pastos Chicos, Jujuy (Argentina). The soil and water used in the trial presented 49 and 1.44 mg/L As concentration levels, respectively. Total dry biomass (TDB) and total As were determined in soils, roots and leaves. The latter was quantified by atomic absorption spectrometry with hydride generation, and bioconcentration and translocation factors were determined...
April 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29650307/development-of-an-information-retrieval-tool-for-biomedical-patents
#8
Tiago Alves, Rúben Rodrigues, Hugo Costa, Miguel Rocha
BACKGROUND AND OBJECTIVE: The volume of biomedical literature has been increasing in the last years. Patent documents have also followed this trend, being important sources of biomedical knowledge, technical details and curated data, which are put together along the granting process. The field of Biomedical text mining (BioTM) has been creating solutions for the problems posed by the unstructured nature of natural language, which makes the search of information a challenging task. Several BioTM techniques can be applied to patents...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29624632/advances-in-industrial-biopharmaceutical-batch-process-monitoring-machine-learning-methods-for-small-data-problems
#9
Aditya Tulsyan, Christopher Garvin, Cenk Undey
Biopharmaceutical manufacturing comprises of multiple distinct processing steps that require effective and efficient monitoring of many variables simultaneously in real-time. The state-of-the-art real-time multivariate statistical batch process monitoring (BPM) platforms have been in use in recent years to ensure comprehensive monitoring is in place as a complementary tool for continued process verification to detect weak signals. This article addresses a longstanding, industry-wide problem in BPM, referred to as the 'Low-N' problem, wherein a product has a limited production history...
April 6, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29571119/improved-phosphometabolome-profiling-applying-isotope-dilution-strategy-and-capillary-ion-chromatography-tandem-mass-spectrometry
#10
Marit H Stafsnes, Lisa M Røst, Per Bruheim
The phosphometabolome is comprised of all phosphorylated metabolites including the major metabolite classes sugar phosphates and nucleoside phosphates. Phosphometabolites are invaluable in any cell as a part of primary- and energy- metabolism, and as building blocks in the biosynthesis of macromolecules. Here, we report quantitative profiling of the phosphometabolome by applying capillary ion chromatography-tandem mass spectrometry (capIC-MS/MS), ensuring improved chromatographic separation, robustness and quantitative precision...
February 6, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29567492/paternal-cocaine-disrupts-offspring-circadian-clock-function-in-a-sex-dependent-manner-in-mice
#11
Alexandra M Yaw, Robert W Woodruff, Rebecca A Prosser, J David Glass
The present study is the first to explore the multigenerational effects of mammalian paternal cocaine intake on offspring (F1) circadian clock regulation. Parental cocaine use poses significant health risks to the offspring, through both maternal and paternal drug influences. With respect to the latter, recent evidence suggests that a paternal mode of cocaine inheritance involves epigenetic germ line actions that can ultimately disrupt offspring behavior. Based on our previous report in mice that free-running circadian period (tau) is chronically lengthened following withdrawal from long term cocaine treatment, the present study was undertaken to explore potential epigenetic effects of paternal exposure to cocaine over the ∼40 day murine spermatogenic cycle on F1 circadian regulatory functions...
March 19, 2018: Neuroscience
https://www.readbyqxmd.com/read/29566830/affordability-challenges-to-value-based-pricing-mass-diseases-orphan-diseases-and-cures
#12
Patricia M Danzon
OBJECTIVES: To analyze how value-based pricing (VBP), which grounds the price paid for pharmaceuticals in their value, can manage "affordability" challenges, defined as drugs that meet cost-effectiveness thresholds but are "unaffordable" within the short-run budget. METHODS: Three specific contexts are examined, drawing on recent experience. First, an effective new treatment for a chronic, progressive disease, such as hepatitis C, creates a budget spike that is transitory because initial prevalence is high, relative to current incidence...
March 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29565564/xplex-an-effective-multiplex-cross-linking-chemistry-for-acidic-residues
#13
Mariana Fioramonte, Hugo Cesar Ramos de Jesus, Allan Jhonathan Ramos Ferrari, Diogo Borges Lima, Roberta Lopes Drekener, Carlos Roque Duarte Correia, Luciana Gonzaga Oliveira, Ana Gisele da Costa Neves-Ferreira, Paulo Costa Carvalho, Fabio Cesar Gozzo
Cross-linking/Mass spectrometry (XLMS) is a consolidated technique for structural characterization of proteins and protein complexes. Despite its success, the cross-linking chemistry currently used is mostly based on N-hydroxysuccinimed (NHS) esters, which react primarily with lysine residues. One way to expand the current applicability of XLMS into several new areas is to increase the number of cross-links obtainable for a target protein. We introduce a multiplex chemistry (denoted XPlex) that targets Asp, Glu, Lys, and Ser residues...
March 22, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29551845/development-of-a-novel-loading-device-for-studying-magnesium-degradation-under-compressive-load-for-implant-applications
#14
Qiaomu Tian, Jose Antonio Mendez, Laura Rivera-Castaneda, Omar Mahmood, Adam Showalter, Elizabeth Ang, Sarah Kazmi, Huinan Liu
Medical implants play a key role in treating bone fractures. Permanent implants are currently used for immobilization of fractures and bearing physiological loads during bone healing. After bone has healed, these implants, if not removed, often cause complications in the long run; and secondary surgeries for removing them pose additional discomfort and expenses for patients. Magnesium (Mg)-based bioresorbable implants, can potentially eliminate the need for additional surgeries by degrading safely over time in the human body...
April 15, 2018: Materials Letters
https://www.readbyqxmd.com/read/29550789/simulation-experiment-description-markup-language-sed-ml-level-1-version-3-l1v3
#15
Frank T Bergmann, Jonathan Cooper, Matthias König, Ion Moraru, David Nickerson, Nicolas Le Novère, Brett G Olivier, Sven Sahle, Lucian Smith, Dagmar Waltemath
The creation of computational simulation experiments to inform modern biological research poses challenges to reproduce, annotate, archive, and share such experiments. Efforts such as SBML or CellML standardize the formal representation of computational models in various areas of biology. The Simulation Experiment Description Markup Language (SED-ML) describes what procedures the models are subjected to, and the details of those procedures. These standards, together with further COMBINE standards, describe models sufficiently well for the reproduction of simulation studies among users and software tools...
March 19, 2018: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/29533977/testing-of-alignment-parameters-for-ancient-samples-evaluating-and-optimizing-mapping-parameters-for-ancient-samples-using-the-tapas-tool
#16
Ulrike H Taron, Moritz Lell, Axel Barlow, Johanna L A Paijmans
High-throughput sequence data retrieved from ancient or other degraded samples has led to unprecedented insights into the evolutionary history of many species, but the analysis of such sequences also poses specific computational challenges. The most commonly used approach involves mapping sequence reads to a reference genome. However, this process becomes increasingly challenging with an elevated genetic distance between target and reference or with the presence of contaminant sequences with high sequence similarity to the target species...
March 13, 2018: Genes
https://www.readbyqxmd.com/read/29533817/poap-a-gnu-parallel-based-multithreaded-pipeline-of-open-babel-and-autodock-suite-for-boosted-high-throughput-virtual-screening
#17
A Samdani, Umashankar Vetrivel
High throughput virtual screening plays a crucial role in hit identification during the drug discovery process. With the rapid increase in the chemical libraries, virtual screening process becomes computationally challenging, thereby posing a demand for efficiently parallelized software pipelines. Here we present a GNU Parallel based pipeline-POAP that is programmed to run Open Babel and AutoDock suite under highly optimized parallelization. The ligand preparation module is a unique feature in POAP, as it offers extensive options for geometry optimization, conformer generation, parallelization and also quarantines erroneous datasets for seamless operation...
March 1, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29448365/improved-belief-propagation-algorithm-finds-many-bethe-states-in-the-random-field-ising-model-on-random-graphs
#18
G Perugini, F Ricci-Tersenghi
We first present an empirical study of the Belief Propagation (BP) algorithm, when run on the random field Ising model defined on random regular graphs in the zero temperature limit. We introduce the notion of extremal solutions for the BP equations, and we use them to fix a fraction of spins in their ground state configuration. At the phase transition point the fraction of unconstrained spins percolates and their number diverges with the system size. This in turn makes the associated optimization problem highly non trivial in the critical region...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29419793/microbiological-values-of-rainwater-harvested-in-adelaide
#19
Chirhakarhula Emmanuel Chubaka, Harriet Whiley, John W Edwards, Kirstin E Ross
In Australia, rainwater is an important source of water for many households. Unlike municipal water, rainwater is often consumed untreated. This study investigated the potential contamination of rainwater by microorganisms. Samples from 53 rainwater tanks across the Adelaide region were collected and tested using Colilert™ IDEXX Quanti-Tray*/2000. Twenty-eight out of the 53 tanks (53%) contained Escherichia coli . Samples collected from ten tanks contained E. coli at concentrations exceeding the limit of 150 MPN/100 mL for recreational water quality...
February 8, 2018: Pathogens
https://www.readbyqxmd.com/read/29396125/performing-an-informatics-consult-methods-and-challenges
#20
Alejandro Schuler, Alison Callahan, Kenneth Jung, Nigam H Shah
Our health care system is plagued by missed opportunities, waste, and harm. Data generated in the course of care are often underutilized, scientific insight goes untranslated, and evidence is overlooked. To address these problems, we envisioned a system where aggregate patient data can be used at the bedside to provide practice-based evidence. To create that system, we directly connect practicing physicians to clinical researchers and data scientists through an informatics consult. Our team processes and classifies questions posed by clinicians, identifies the appropriate patient data to use, runs the appropriate analyses, and returns an answer, ideally in a 48-hour time window...
March 2018: Journal of the American College of Radiology: JACR
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