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https://www.readbyqxmd.com/read/29168199/experimental-investigation-of-left-ventricular-flow-patterns-after-percutaneous-edge-to-edge-mitral-valve-repair
#1
Morteza Jeyhani, Shahrokh Shahriari, Michel Labrosse
Mitral valve percutaneous edge-to-edge repair (PEtER) is a viable solution in high-risk patients with severe symptomatic mitral regurgitation. However, the generated double-orifice configuration poses challenges for the evaluation of the hemodynamic performance of the mitral valve and may alter flow patterns in the left ventricle (LV) during diastole. This in vitro study aims to evaluate the hemodynamic modifications following a simulated PEtER. A custom-made mitral valve was developed, and two configurations were tested: (i) a single-orifice valve with mitral regurgitation and (ii) a double-orifice mitral valve configuration following PEtER...
November 23, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29150937/cgmp-production-and-analysis-of-bg505-sosip-664-an-extensively-glycosylated-trimeric-hiv-1-envelope-glycoprotein-vaccine-candidate
#2
Antu K Dey, Albert Cupo, Gabriel Ozorowski, Vaneet K Sharma, Anna-Janina Behrens, Eden P Go, Thomas J Ketas, Anila Yasmeen, Per J Klasse, Eddy Sayeed, Heather Desaire, Max Crispin, Ian A Wilson, Rogier W Sanders, Thomas Hassell, Andrew Ward, John P Moore
We describe the properties of BG505 SOSIP.664 HIV-1 envelope glycoprotein trimers produced under current Good Manufacturing Practice (cGMP) conditions. These proteins are the first of a new generation of native-like trimers that are the basis for many structure-guided immunogen development programs aimed at devising how to induce broadly neutralizing antibodies (bNAbs) to HIV-1 by vaccination. The successful translation of this prototype demonstrates the feasibility of producing similar immunogens on an appropriate scale and of an acceptable quality for Phase I experimental medicine clinical trials...
November 18, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29149853/cost-of-delivering-health-care-services-at-primary-health-facilities-in-ghana
#3
Maxwell Ayindenaba Dalaba, Paul Welaga, Chieko Matsubara
BACKGROUND: There is limited knowledge on the cost of delivering health services at primary health care facilities in Ghana which is posing a challenge in resource allocations. This study therefore estimated the cost of providing health care in primary health care facilities such as Health Centres (HCs) and Community-based Health Planning and Services (CHPS) in Ghana. METHODS: The study was cross-sectional and quantitative data was collected from the health provider perspective...
November 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29073131/human-action-recognition-based-on-kinematic-similarity-in-real-time
#4
Qingqiang Wu, Guanghua Xu, Longting Chen, Ailing Luo, Sicong Zhang
Human action recognition using 3D pose data has gained a growing interest in the field of computer robotic interfaces and pattern recognition since the availability of hardware to capture human pose. In this paper, we propose a fast, simple, and powerful method of human action recognition based on human kinematic similarity. The key to this method is that the action descriptor consists of joints position, angular velocity and angular acceleration, which can meet the different individual sizes and eliminate the complex normalization...
2017: PloS One
https://www.readbyqxmd.com/read/29040432/machine-learning-accelerates-md-based-binding-pose-prediction-between-ligands-and-proteins
#5
Kei Terayama, Hiroaki Iwata, Mitsugu Araki, Yasushi Okuno, Koji Tsuda
Motivation: Fast and accurate prediction of protein-ligand binding structures is indispensable for structure-based drug design (SBDD) and accurate estimation of binding free energy of drug candidate molecules in drug discovery. Recently, accurate pose prediction methods based on short-MD simulations such as MM-PBSA and MM-GBSA among generated docking poses have been used. Since molecular structures obtained from MD simulation depends on the initial condition, taking the average over different initial conditions leads to better accuracy...
October 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29022952/ocular-morbidity-among-porters-at-high-altitudes
#6
Subodh Gnyawali, Gauri Shankar Shrestha, Safal Khanal, Talisa Dennis, John C Spencer
INTRODUCTION: High altitude, often characterized by settings over 2400m, can be detrimental to the human body and pose a significant risk to ocular health. Reports concerning various ocular morbidities occurring as a consequence of high altitude are limited in the current literature. OBJECTIVES: This study was aimed at evaluating the ocular health of porters working at high altitudesof Himalayas in Nepal. MATERIALS AND METHODS: A mobile eye clinic was set up in Ghat and patient data were collected from its out- patient unit by a team of seven optometrists which was run for five days...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28963926/hydrostatic-pressure-and-temperature-affect-the-tolerance-of-the-free-living-marine-nematode-halomonhystera-disjuncta-to-acute-copper-exposure
#7
Lisa Mevenkamp, Alastair Brown, Chris Hauton, Anna Kordas, Sven Thatje, Ann Vanreusel
Potential deep-sea mineral extraction poses new challenges for ecotoxicological research since little is known about effects of abiotic conditions present in the deep sea on the toxicity of heavy metals. Due to the difficulty of collecting and maintaining deep-sea organisms alive, a first step would be to understand the effects of high hydrostatic pressure and low temperatures on heavy metal toxicity using shallow-water relatives of deep-sea species. Here, we present the results of acute copper toxicity tests on the free-living shallow-water marine nematode Halomonhystera disjuncta, which has close phylogenetic and ecological links to the bathyal species Halomonhystera hermesi...
September 20, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28947764/on-the-long-run-efficacy-of-punishments-and-recommendations-in-a-laboratory-public-goods-game
#8
Ananish Chaudhuri, Tirnud Paichayontvijit
We use decision-making experiments with human participants to study cooperation in a laboratory public goods game. Such games pose a conflict between cooperating, which is socially optimal and free-riding, which promotes individual self-interest. Prior research emphasizes the need for de-centralized peer-to-peer punishments as an evolutionarily stable response to the problem of free-riding, especially where interactions occur over long horizons. We show that a simple exhortative message appealing to participants' goodwill can achieve high rates of cooperation in social dilemmas played over many rounds, even in the absence of punishments for free-riding...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28913782/docking-of-small-molecules-to-farnesoid-x-receptors-using-autodock-vina-with-the-convex-pl-potential-lessons-learned-from-d3r-grand-challenge-2
#9
Maria Kadukova, Sergei Grudinin
The 2016 D3R Grand Challenge 2 provided an opportunity to test multiple protein-ligand docking protocols on a set of ligands bound to farnesoid X receptor that has many available experimental structures. We participated in the Stage 1 of the Challenge devoted to the docking pose predictions, with the mean RMSD value of our submission poses of 2.9 Å. Here we present a thorough analysis of our docking predictions made with AutoDock Vina and the Convex-PL rescoring potential by reproducing our submission protocol and running a series of additional molecular docking experiments...
September 14, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28902511/exploring-the-stability-of-ligand-binding-modes-to-proteins-by-molecular-dynamics-simulations-a-cross-docking-study
#10
Kai Liu, Hironori Kokubo
Docking has become an indispensable approach in drug discovery research to predict the binding mode of a ligand. One great challenge in docking is to efficiently refine the correct pose from various putative docking poses through scoring functions. We recently examined the stability of self-docking poses under molecular dynamics (MD) simulations and showed that equilibrium MD simulations have some capability to discriminate between correct and decoy poses. Here, we have extended our previous work to cross-docking studies for practical applications...
October 23, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28895578/challenges-in-comprehensive-management-of-spinal-cord-injury-in-india-and-in-the-asian-spinal-cord-network-region-findings-of-a-survey-of-experts-patients-and-consumers
#11
H S Chhabra, S Sharma, M Arora
STUDY DESIGN: Online survey. OBJECTIVES: To understand the prevailing scenario of the comprehensive management of spinal cord injuries (SCI) in India and in the Asian Spinal Cord Network (ASCoN) region, especially with a view to document the challenges faced and its impact. SETTING: Indian Spinal Injuries Centre. METHODS: A questionnaire was designed which covered various aspects of SCI management. Patients, consumers (spinal injured patients discharged since at least 1 year) and experts in SCI management from different parts of India and the ASCoN region were approached to complete the survey...
September 12, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28880549/binding-and-release-between-polymeric-carrier-and-protein-drug-ph-mediated-interplay-of-coulomb-forces-hydrogen-bonding-van-der-waals-interactions-and-entropy
#12
Sergio De Luca, Fan Chen, Prasenjit Seal, Martina H Stenzel, Sean C Smith
The accelerating search for new types of drugs and delivery strategies poses challenge to understanding the mechanism of delivery. To this end, a detailed atomistic picture of binding between the drug and carrier is quintessential. Although many studies focus on the electrostatics of drug-vector interactions, it has also been pointed out that entropic factors relating to water and counterions can play an important role. By carrying out extensive molecular dynamics simulations and subsequently validating with experiments, we shed light herein on the binding in aqueous solution between a protein drug and polymeric carrier...
October 2, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28830236/testing-many-treatments-within-a-single-protocol-over-10%C3%A2-years-at-mrc-clinical-trials-unit-at-ucl-multi-arm-multi-stage-platform-umbrella-and-basket-protocols
#13
Mahesh Kb Parmar, Fay H Cafferty, Matthew R Sydes, Babak Choodari-Oskooei, Ruth E Langley, Louise Brown, Patrick Pj Phillips, Melissa R Spears, Sam Rowley, Richard Kaplan, Nicholas D James, Timothy Maughan, Nicholas Paton, Patrick J Royston
BACKGROUND: There is real need to change how we do some of our clinical trials, as currently the testing and development process is too slow, too costly and too failure-prone - often we find that a new treatment is no better than the current standard. PURPOSE AND METHODS: Much of the focus on the development and testing pathway has been in improving the design of phase I and II trials. In this paper we present examples of new methods for improving the design of phase III trials (and the necessary lead up to them) as they are the most time-consuming and expensive part of the pathway...
August 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28797548/efficient-and-robust-cell-detection-a-structured-regression-approach
#14
Yuanpu Xie, Fuyong Xing, Xiaoshuang Shi, Xiangfei Kong, Hai Su, Lin Yang
Efficient and robust cell detection serves as a critical prerequisite for many subsequent biomedical image analysis methods and computer-aided diagnosis (CAD). It remains a challenging task due to touching cells, inhomogeneous background noise, and large variations in cell sizes and shapes. In addition, the ever-increasing amount of available datasets and the high resolution of whole-slice scanned images pose a further demand for efficient processing algorithms. In this paper, we present a novel structured regression model based on a proposed fully residual convolutional neural network for efficient cell detection...
July 26, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28755474/controlling-localization-of-escherichia-coli-populations-using-a-two-part-synthetic-motility-circuit-an-accelerator-and-brake
#15
Ryan McKay, Pricila Hauk, Hsuan-Chen Wu, Alex Eli Pottash, Wu Shang, Jessica Terrell, Gregory F Payne, William E Bentley
Probiotics, whether taken as capsules or consumed in foods, have been regarded as safe for human use by regulatory agencies. Being living cells, they serve as "tunable" factories for the synthesis of a vast array of beneficial molecules. The idea of reprogramming probiotics to act as controllable factories, producing potential therapeutic molecules under user-specified conditions, represents a new and powerful concept in drug synthesis and delivery. Probiotics that serve as drug delivery vehicles pose several challenges, one being targeting (as seen with nanoparticle approaches)...
December 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28746386/tracmit-an-effective-pipeline-for-tracking-and-analyzing-cells-on-micropatterns-through-mitosis
#16
Olivier Burri, Benita Wolf, Arne Seitz, Pierre Gönczy
The use of micropatterns has transformed investigations of dynamic biological processes by enabling the reproducible analysis of live cells using time-lapse fluorescence microscopy. With micropatterns, thousands of individual cells can be efficiently imaged in parallel, rendering the approach well suited for screening projects. Despite being powerful, such screens remain challenging in terms of data handling and analysis. Typically, only a fraction of micropatterns is occupied in a manner suitable to monitor a given phenotypic output...
2017: PloS One
https://www.readbyqxmd.com/read/28711845/the-impact-of-synoptic-circulation-on-air-quality-and-pollution-related-human-health-in-the-yangtze-river-delta-region
#17
Zhiheng Liao, Meng Gao, Jiaren Sun, Shaojia Fan
PM2.5 and O3 pollution are of concern for the Yangtze River Delta (YRD) region due to their adverse impact on human health. In conjunction with a complex distribution of emission sources, the synoptic circulation conditions control the temporal and spatial variability of air pollution levels and hence the pollution-related health burdens. In this study, a long-term synoptic circulation catalogue is developed by applying the automated Lamb weather type method to the ECMWF mean sea level pressure reanalysis for the YRD region during 2013-2016...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28710977/assessing-the-toxicity-and-risk-of-salt-impacted-winter-road-runoff-to-the-early-life-stages-of-freshwater-mussels-in-the-canadian-province-of-ontario
#18
R S Prosser, Q Rochfort, R McInnis, K Exall, P L Gillis
In temperate urbanized areas where road salting is used for winter road maintenance, the level of chloride in surface waters has been increasing. While a number of studies have shown that the early-life stages of freshwater mussels are particularly sensitive to salt; few studies have examined the toxicity of salt-impacted winter road runoff to the early-life stages of freshwater mussels to confirm that chloride is the driver of toxicity in this mixture. This study examines the acute toxicity of field-collected winter road runoff to the glochidia of wavy-rayed lampmussels (Lampsilis fasciola) (48 h exposure) and newly released juvenile fatmucket mussels (Lampsilis siliquoidea) (<1 week old; 96 h exposure) under different water hardness...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28693467/predicting-rna-hyper-editing-with-a-novel-tool-when-unambiguous-alignment-is-impossible
#19
Wilson H McKerrow, Yiannis A Savva, Ali Rezaei, Robert A Reenan, Charles E Lawrence
BACKGROUND: Repetitive elements are now known to have relevant cellular functions, including self-complementary sequences that form double stranded (ds) RNA. There are numerous pathways that determine the fate of endogenous dsRNA, and misregulation of endogenous dsRNA is a driver of autoimmune disease, particularly in the brain. Unfortunately, the alignment of high-throughput, short-read sequences to repeat elements poses a dilemma: Such sequences may align equally well to multiple genomic locations...
July 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28682063/history-matters-pre-exposure-to-wastewater-enhances-pesticide-toxicity-in-invertebrates
#20
Jochen P Zubrod, Dominic Englert, Simon Lüderwald, Sandra Poganiuch, Ralf Schulz, Mirco Bundschuh
Disturbance regimes determine communities' structure and functioning. Nonetheless, little effort has been undertaken to understand interactions of press and pulse disturbances. In this context, leaf-shredding macroinvertebrates can be chronically exposed to wastewater treatment plant effluents (i.e., press disturbance) before experiencing pesticide exposure following agricultural runoff (i.e., pulse disturbance). It is assumed that wastewater pre-exposure alters animals' sensitivity to pesticides. To test this hypothesis, we exposed model-populations of the shredder Gammarus fossarum to wastewater at three field-relevant dilution levels (i...
July 25, 2017: Environmental Science & Technology
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