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https://www.readbyqxmd.com/read/28342105/real-time-surgical-tool-tracking-and-pose-estimation-using-a-hybrid-cylindrical-marker
#1
Lin Zhang, Menglong Ye, Po-Ling Chan, Guang-Zhong Yang
PURPOSE: To provide an integrated visualisation of intraoperative ultrasound and endoscopic images to facilitate intraoperative guidance, real-time tracking of the ultrasound probe is required. State-of-the-art methods are suitable for planar targets while most of the laparoscopic ultrasound probes are cylindrical objects. A tracking framework for cylindrical objects with a large work space will improve the usability of the intraoperative ultrasound guidance. METHODS: A hybrid marker design that combines circular dots and chessboard vertices is proposed for facilitating tracking cylindrical tools...
March 24, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28340552/strauto-automation-and-parallelization-of-structure-analysis
#2
Vikram E Chhatre, Kevin J Emerson
BACKGROUND: Population structure inference using the software STRUCTURE has become an integral part of population genetic studies covering a broad spectrum of taxa including humans. The ever-expanding size of genetic data sets poses computational challenges for this analysis. Although at least one tool currently implements parallel computing to reduce computational overload of this analysis, it does not fully automate the use of replicate STRUCTURE analysis runs required for downstream inference of optimal K...
March 24, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28333193/increased-activity-of-colistin-in-combination-with-amikacin-against-escherichia-coli-co-producing-ndm-5-and-mcr-1
#3
Yu-Feng Zhou, Meng-Ting Tao, Youjun Feng, Run-Shi Yang, Xiao-Ping Liao, Ya-Hong Liu, Jian Sun
Objectives: Colistin and carbapenem are two lines of last-resort antibiotics against lethal infections caused by MDR Gram-negative pathogens. The emergence of carbapenemase-positive Escherichia coli with colistin resistance poses a serious threat to public health worldwide. Here we report, for the first time (to the best of our knowledge), a novel combination therapy used for the treatment of E. coli co-producing MCR-1 and NDM-5. Methods: The MICs of colistin were determined alone and with 1-4 mg/L amikacin...
February 20, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28275173/tropism-and-innate-host-responses-of-influenza-a-h5n6-virus-an-analysis-of-ex%C3%A2-vivo-and-in-vitro-cultures-of-the-human-respiratory-tract
#4
Kenrie P Y Hui, Louisa L Y Chan, Denise I T Kuok, Chris K P Mok, Zi-Feng Yang, Run-Feng Li, Geraldine S M Luk, Elaine F Lee, Jimmy C C Lai, Hui-Ling Yen, Huachen Zhu, Yi Guan, John M Nicholls, J S Malik Peiris, Michael C W Chan
Since their first isolation in 2013, influenza A/H5N6 viruses have spread amongst poultry across multiple provinces in China and to Laos, Vietnam and Myanmar. So far, there have been 14 human H5N6 infections with 10 fatalities.We investigated the tropism, replication competence and cytokine induction of one human and two avian H5N6 isolates in ex vivo and in vitro cultures derived from the human respiratory tract. Virus tropism and replication were studied in ex vivo cultures of human nasopharynx, bronchus and lung...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28259462/standardization-proposal-of-soft-tissue-artefact-description-for-data-sharing-in-human-motion-measurements
#5
Andrea Cereatti, Tecla Bonci, Massoud Akbarshahi, Kamiar Aminian, Arnaud Barré, Mickael Begon, Daniel L Benoit, Caecilia Charbonnier, Fabien Dal Maso, Silvia Fantozzi, Cheng-Chung Lin, Tung-Wu Lu, Marcus G Pandy, Rita Stagni, Antonie J van den Bogert, Valentina Camomilla
Soft tissue artefact (STA) represents one of the main obstacles for obtaining accurate and reliable skeletal kinematics from motion capture. Many studies have addressed this issue, yet there is no consensus on the best available bone pose estimator and the expected errors associated with relevant results. Furthermore, results obtained by different authors are difficult to compare due to the high variability and specificity of the phenomenon and the different metrics used to represent these data. Therefore, the aim of this study was twofold: firstly, to propose standards for description of STA; and secondly, to provide illustrative STA data samples for body segments in the upper and lower extremities and for a range of motor tasks specifically, level walking, stair ascent, sit-to-stand, hip- and knee-joint functional movements, cutting motion, running, hopping, arm elevation and functional upper-limb movements...
February 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28256222/multiple-ligand-unbinding-pathways-and-ligand-induced-destabilization-revealed-by-wexplore
#6
Alex Dickson, Samuel D Lotz
We report simulations of full ligand exit pathways for the trypsin-benzamidine system, generated using the sampling technique WExplore. WExplore is able to observe millisecond-scale unbinding events using many nanosecond-scale trajectories that are run without introducing biasing forces. The algorithm generates rare events by dividing the coordinate space into regions, on-the-fly, and balancing computational effort between regions through cloning and merging steps, as in the weighted ensemble method. The averaged exit flux yields a ligand exit rate of 180 μs, which is within an order of magnitude of the experimental value...
February 28, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28240804/share-35-changes-center-level-liver-acceptance-practices
#7
David S Goldberg, Matthew Levine, Seth Karp, Richard Gilroy, Peter L Abt
Share 35 was implemented to provide improved access to organs for patients with MELD scores ≥35. However, little is known about the impact of Share 35 on organ offer acceptance rates. We evaluated all liver offers to adult patients that were ultimately transplanted between 1/1/2011-12/31/2015. The analyses focused on patients ranked in the top five positions of a given match run, and used multi-level mixed-effects models, clustering on individual waitlist candidate and transplant center. There was a significant interaction between Share 35 era and MELD category (p<0...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28237187/comparative-assessment-of-knee-joint-models-used-in-multi-body-kinematics-optimisation-for-soft-tissue-artefact-compensation
#8
Vincent Richard, Aurelio Cappozzo, Raphaël Dumas
Estimating joint kinematics from skin-marker trajectories recorded using stereophotogrammetry is complicated by soft tissue artefact (STA), an inexorable source of error. One solution is to use a bone pose estimator based on multi-body kinematics optimisation (MKO) embedding joint constraints to compensate for STA. However, there is some debate over the effectiveness of this method. The present study aimed to quantitatively assess the degree of agreement between reference (i.e., artefact-free) knee joint kinematics and the same kinematics estimated using MKO embedding six different knee joint models...
January 31, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28208286/derivatization-technique-to-identify-specifically-carbonyl-groups-by-infrared-spectroscopy-characterization-of-photooxidative-aging-products-in-terpenes-and-terpeneous-resins
#9
Stefan Zumbühl, Andreas Brändle, Andreas Hochuli, Nadim C Scherrer, Walter Caseri
Analysis of bioorganic materials by infrared spectroscopy (FT-IR) is frequently limited due to overlapping of diagnostic bands from the various components, which poses a fundamental problem to this analytical technique. The distinction of oxidized di- and triterpenes, for example, is hindered by the superposition of similar absorption bands of carbonyl functional groups summing up to a broad, nondistinctive signal. This study presents a technique for selective fluorination of various carboxylic acids by exposure to gaseous sulfur tetrafluoride...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28187410/jllumina-a-comprehensive-java-based-api-for-statistical-illumina-infinium-humanmethylation450-and-methylationepic-data-processing
#10
Diogo Almeida, Ida Skov, Jesper Lund, Afsaneh Mohammadnejad, Artur Silva, Fabio Vandin, Qihua Tan, Jan Baumbach, Richard Röttger
Measuring differential methylation of the DNA is the nowadays most common approach to linking epigenetic modifications to diseases (called epigenome-wide association studies, EWAS). For its low cost, its efficiency and easy handling, the Illumina HumanMethylation450 BeadChip and its successor, the Infinium MethylationEPIC BeadChip, is the by far most popular techniques for conduction EWAS in large patient cohorts. Despite the popularity of this chip technology, raw data processing and statistical analysis of the array data remains far from trivial and still lacks dedicated software libraries enabling high quality and statistically sound downstream analyses...
December 18, 2016: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28179076/challenges-for-the-wfd-second-management-cycle-after-the-implementation-of-a-regional-multi-municipality-sanitation-system-in-a-coastal-lagoon-ria-de-aveiro-portugal
#11
M L Lopes, B Marques, J M Dias, A M V M Soares, A I Lillebø
In the scope of the first WDF management cycle, a multi-municipality sanitation system with secondary treatment was implemented in 2005 in Ria de Aveiro coastal lagoon, with the treated effluent discharging into the Atlantic Ocean through a submarine outfall. The lagoon water chemical status was evaluated regarding dissolved inorganic nutrients and chlorophyll a before and after 2005. The S. Jacinto outfall has effectively reduced the point source nutrient loads (ammonium and phosphate) into Ria de Aveiro, representing a step forward for the implementation of the WFD, through eutrophication abatement...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28169176/breast-health-services-accuracy-of-benefit%C3%A2-coverage-information-in-the-individual-insurance-marketplace
#12
Mariam S Hamid, Giselle E Kolenic, Jessica Dozier, Vanessa K Dalton, Ruth C Carlos
PURPOSE: The aim of this study was to determine if breast health coverage information provided by customer service representatives employed by insurers offering plans in the 2015 federal and state health insurance marketplaces is consistent with Patient Protection and Affordable Care Act (ACA) and state-specific legislation. METHODS: One hundred fifty-eight unique customer service numbers were identified for insurers offering plans through the federal marketplace, augmented with four additional numbers representing the Connecticut state-run exchange...
January 27, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28166498/real-time-interactive-tree-animation
#13
Ed Quigley, Yue Yu, Jingwei Huang, Winnie Lin, Ronald Fedkiw
We present a novel method for posing and animating botanical tree models interactively in real time. Unlike other state of the art methods which tend to produce trees that are overly flexible, bending and deforming as if they were underwater plants, our approach allows for arbitrarily high stiffness while still maintaining real-time frame rates without spurious artifacts, even on quite large trees with over ten thousand branches. This is accomplished by using an articulated rigid body model with as-stiff-as-desired rotational springs in conjunction with our newly proposed simulation technique, which is motivated both by position based dynamics and the typical O(N) algorithms for articulated rigid bodies...
January 30, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28164158/quasi-solid-state-rechargeable-na-co2-batteries-with-reduced-graphene-oxide-na-anodes
#14
Xiaofei Hu, Zifan Li, Yaran Zhao, Jianchao Sun, Qing Zhao, Jianbin Wang, Zhanliang Tao, Jun Chen
Na-CO2 batteries using earth-abundant Na and greenhouse gas CO2 are promising tools for mobile and stationary energy storage, but they still pose safety risks from leakage of liquid electrolyte and instability of the Na metal anode. These issues result in extremely harsh operating conditions of Na-CO2 batteries and increase the difficulty of scaling up this technology. We report the development of quasi-solid state Na-CO2 batteries with high safety using composite polymer electrolyte (CPE) and reduced graphene oxide (rGO) Na anodes...
February 2017: Science Advances
https://www.readbyqxmd.com/read/28135201/use-of-a-dehydrated-amniotic-membrane-allograft-in-the-treatment-of-lower-extremity-wounds-a-retrospective-cohort-study
#15
Eric J Lullove
Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. MATERIALS AND METHODS: Twenty patients were selected from the author's patient population at the West Boca Center for Wound Healing for a retrospective cohort study. Patients underwent a run-in period of 2 weeks, where standard of care was used to clear the wound of bioburden...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28122616/improving-safety-in-care-homes-protocol-for-evaluation-of-the-walsall-and-wolverhampton-care-home-improvement-programme
#16
Sarah Damery, Sarah Flanagan, Kiran Rai, Gill Combes
BACKGROUND: Improving safety in care homes is becoming increasingly important. Care home residents typically have multiple physical and/or cognitive impairments, and adverse events like falls often lead to hospital attendance or admission. Developing a safety culture is associated with beneficial impacts on safety outcomes, but the complex needs of care home residents, coupled with staffing pressures in the sector, pose challenges for positive safety practices to become embedded at the individual and organisational levels...
January 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28113835/poor-man-s-virtual-camera-real-time-simultaneous-matting-and-camera-pose-estimation
#17
Istvan Szentandrasi, Marketa Dubska, Michal Zacharias, Adam Herout
Today's film and advertisement production heavily uses computer graphics combined with living actors by chromakeying. The matchmoving process typically takes a considerable manual effort. Semi-automatic matchmoving tools exist as well, but they still work offline and require manual check-up and correction. In this article, we propose an instant matchmoving solution for green screen. It uses a recent technique of planar uniform marker fields. Our technique can be used in indie and professional filmmaking as a cheap and ultramobile virtual camera, and for shot prototyping and storyboard creation...
March 18, 2016: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28113458/marginal-space-deep-learning-efficient-architecture-for-volumetric-image-parsing
#18
Florin C Ghesu, Edward Krubasik, Bogdan Georgescu, Vivek Singh, Yefeng Zheng, Joachim Hornegger, Dorin Comaniciu
Robust and fast solutions for anatomical object detection and segmentation support the entire clinical workflow from diagnosis, patient stratification, therapy planning, intervention and follow-up. Current state-of-the-art techniques for parsing volumetric medical image data are typically based on machine learning methods that exploit large annotated image databases. There are two main challenges that need to be addressed, these are the efficiency in processing large volumetric input images and the need for strong, representative image features...
March 7, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28111036/an-lc-ms-ms-method-for-the-simultaneous-determination-of-15-antipsychotics-and-two-metabolites-in-hair-and-its-application-to-rat-hair
#19
Juhyun Sim, Eunmi Kim, Wonkyung Yang, Sanghee Woo, Sangwhan In
In recent years, the inappropriate use of antipsychotics by young Korean men has become a social problem. As military service exemptions are given for mental illness, some men pose as mental health patients to avoid military service. In order to verify the authenticity of mental illnesses, we developed simultaneous analytical methods for the detection of 15 antipsychotics and 2 of their metabolites in hair using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The target drugs were modafinil, atomoxetine, aripiprazole, benztropine, buspirone, duloxetine, gabapentin, oxcarbazepine, topiramate, escitalopram, paliperidone, ziprasidone, lamotrigine, clonazepam, levetiracetam, and metabolites of oxcarbazepine and clonazepam...
January 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28107447/a-software-tool-for-estimation-of-burden-of-infectious-diseases-in-europe-using-incidence-based-disability-adjusted-life-years
#20
Edoardo Colzani, Alessandro Cassini, Daniel Lewandowski, Marie-Josee J Mangen, Dietrich Plass, Scott A McDonald, Alies van Lier, Juanita A Haagsma, Guido Maringhini, Alessandro Pini, Piotr Kramarz, Mirjam E Kretzschmar
The burden of disease framework facilitates the assessment of the health impact of diseases through the use of summary measures of population health such as Disability-Adjusted Life Years (DALYs). However, calculating, interpreting and communicating the results of studies using this methodology poses a challenge. The aim of the Burden of Communicable Disease in Europe (BCoDE) project is to summarize the impact of communicable disease in the European Union and European Economic Area Member States (EU/EEA MS)...
2017: PloS One
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