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https://www.readbyqxmd.com/read/28934940/human-development-index-hdi-of-the-maternal-country-of-origin-as-a-predictor-of-perinatal-outcomes-a-longitudinal-study-conducted-in-spain
#1
S Garcia-Tizon Larroca, J Arevalo-Serrano, A Duran Vila, M P Pintado Recarte, I Cueto Hernandez, A Solis Pierna, S Lizarraga Bonelli, J De Leon-Luis
BACKGROUND: In an era of worldwide population displacement, recent studies have identified strong associations between social situations and perinatal outcomes among immigrants. Little is known about the effect of maternal social background on pregnancy outcomes. The Human Development Index (HDI) assesses the following dimensions of human development: life expectancy, education level and income. The objective of our study was to determine if maternal HDI may be used to identify women at increased odds of poor pregnancy outcomes...
September 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28932201/the-placental-microbiota-is-altered-among-subjects-with-gestational-diabetes-mellitus-a-pilot-study
#2
Jia Zheng, Xinhua Xiao, Qian Zhang, Lili Mao, Miao Yu, Jianping Xu, Tong Wang
Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother and child. However, the associations between human placental microbiota and GDM are poorly understood. We aimed to profile the placental microbiota of GDM and further define whether or not certain placental microbiota taxon correlates with specific clinical characteristics. Placenta were collected from GDM women and women with normal pregnancies (n = 10, in each group) consecutively recruited at Peking Union Medical College Hospital...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28929093/the-elevated-rate-of-cesarean-section-and-its-contribution-to-non-communicable-chronic-diseases-in-latin-america-the-growing-involvement-of-the-microbiota
#3
REVIEW
Fabien Magne, Alexa Puchi Silva, Bielka Carvajal, Martin Gotteland
The current recommendation of the World Health Organization (WHO) regarding cesarean section (C-section) is that this clinical practice should be carried out only under specific conditions, when the health or life of the mother/newborn dyad is threatened, and that its use should not exceed 10-15% of the total deliveries. However, over the last few decades, the frequency of C-section delivery in medium- and high-income countries has rapidly increased worldwide. This review describes the evolution of this procedure in Latin American countries, showing that today more than half of newborns in the region are delivered by C-section...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28925410/adiponectin-leptin-and-insulin-in-breast-milk-associations-with-maternal-characteristics-and-infant-body-composition-in-the-first-year-of-life
#4
D Chan, S Goruk, A B Becker, P Subbarao, P J Mandhane, S E Turvey, D Lefebvre, M R Sears, C J Field, M B Azad
BACKGROUND/OBJECTIVES: Breastfeeding may protect against excessive weight gain during infancy. However, the breast milk components responsible for this effect are unknown. We examined the variation of three breast milk hormones (adiponectin, leptin and insulin) according to maternal characteristics and determined their association with infant body composition. SUBJECTS/METHODS: We studied a representative subset of 430 breastfed infants in the CHILD birth cohort...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28901544/effect-of-obesity-on-neonatal-hypoglycaemia-in-mothers-with-gestational-diabetes-a-comparative-study
#5
Katherine Collins, Raoul Oehmen, Shailender Mehta
BACKGROUND: Rates of pre-gestational obesity and gestational diabetes mellitus (GDM) are increasing in Australia. While both are established risk factors for neonatal hypoglycaemia, the additive effect of both risks on neonatal hypoglycaemia is not well understood. AIMS: To determine the influence of obesity on neonatal hypoglycaemia among infants born to GDM mothers. The authors hypothesise the presence of a greater frequency and severity of neonatal hypoglycaemia in infants born to obese GDM women...
September 13, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28878831/the-mirage-of-long-term-vital-benefice-risk-for-the-beginning-of-life
#6
Ramona Mohora, Decebal Hudita, Silvia-Maria Stoicescu
INTRODUCTION: Cord blood is the "life" of the fetus until birth. After delivery, the newborn is "single" and forced to adapt to live using the latest resources provided by the mother. Those who believe that a newborn is just a miniature independent adult are just trusting one of the illusions of secular medicine. Cord blood contains precious cells, stem, red and white blood cells. T cells as a part of white blood cells prevent infections and other illnesses. Cochrane Database 2013 published a study reporting the role of delayed umbilical cord clamping for the benefit of infants...
January 2017: Mædica
https://www.readbyqxmd.com/read/28841845/sociodemographic-factors-and-pregnancy-outcomes-associated-with-prepregnancy-obesity-effect-modification-of-parity-in-the-nationwide-epifane-birth-cohort
#7
Julie Boudet-Berquier, Benoit Salanave, Jean-Claude Desenclos, Katia Castetbon
BACKGROUND: In light of the adverse outcomes for mothers and offspring related to maternal obesity, identification of subgroups of women at risk of prepregnancy obesity and its related-adverse issues is crucial for optimizing antenatal care. We aimed to identify sociodemographic factors and maternal and neonatal outcomes associated with prepregnancy obesity, and we tested the effect modification of parity on these associations. METHODS: In 2012, 3368 mothers who had delivered in 136 randomly selected maternity wards were included just after birth in the French birth cohort, Epifane...
August 25, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28836274/interconception-care-for-women-with-a-history-of-gestational-diabetes-for-improving-maternal-and-infant-outcomes
#8
REVIEW
Joanna Tieu, Emily Shepherd, Philippa Middleton, Caroline A Crowther
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with adverse health outcomes for mothers and their infants both perinatally and long term. Women with a history of GDM are at risk of recurrence in subsequent pregnancies and may benefit from intervention in the interconception period to improve maternal and infant health outcomes. OBJECTIVES: To assess the effects of interconception care for women with a history of GDM on maternal and infant health outcomes...
August 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28831005/protective-major-histocompatibility-complex-allele-prevents-type-1-diabetes-by-shaping-the-intestinal-microbiota-early-in-ontogeny
#9
Michael Silverman, Lindsay Kua, Alessandro Tanca, Mauro Pala, Antonio Palomba, Ceylan Tanes, Kyle Bittinger, Sergio Uzzau, Christophe Benoist, Diane Mathis
Certain MHC-II or HLA-D alleles dominantly protect from particular autoimmune diseases. For example, expression of the MHC-II Eα:Eβ complex potently protects nonobese diabetic (NOD) mice, which normally lack this isotype, from spontaneous development of type 1 diabetes. However, the underlying mechanisms remain debated. We investigated MHC-II-mediated protection from type 1 diabetes using a previously reported NOD mouse line expressing an Eα transgene and, thereby, the Eα:Eβ complex. Eα16/NOD females vertically protected their NOD offspring from diabetes and insulitis, an effect that was dependent on the intestinal microbiota; moreover, they developed autoimmunity when treated with certain antibiotics or raised in a germ-free environment...
August 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28825879/e2f1-mediates-high-glucose-induced-neuronal-death-in-cultured-mouse-retinal-explants
#10
Yujiao Wang, Yi Zhou, Lirong Xiao, Shijie Zheng, Naihong Yan, Danian Chen
Diabetic retinopathy (DR) is the most common complication of diabetes and remains one of the major causes of blindness in the world; infants born to diabetic mothers have higher risk of developing retinopathy of prematurity (ROP). While hyperglycemia is a major risk factor, the molecular and cellular mechanisms underlying DR and diabetic ROP are poorly understood. To explore the consequences of retinal cells under high glucose, we cultured wild type or E2f1(-/-) mouse retinal explants from postnatal day 8 with normal glucose, high osmotic or high glucose media...
August 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28810088/the-impact-of-maternal-diabetes-obesity-and-race-on-infant-birth-weights-in-south-dakota
#11
Kari L Halvorson, H Bruce Vogt, Lon Kightlinger, Dennis Stevens
INTRODUCTION: Maternal obesity, high gestational weight gain and diabetes mellitus during pregnancy are known risk factors that correlate with high infant birth weight and the mother's race. Previous studies have focused on low birth weight, prematurity and infant mortality. This study examined the interaction between race, maternal risk factors and high infant birth weights at the population level in South Dakota to identify factors contributing to the high Native American infant birth weights...
February 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28801435/differences-in-the-pregnancy-gestation-period-and-mean-birth-weights-in-infants-born-to-indian-pakistani-bangladeshi-and-white-british-mothers-in-luton-uk-a-retrospective-analysis-of-routinely-collected-data
#12
Rebecca Garcia, Nasreen Ali, Andy Guppy, Malcolm Griffiths, Gurch Randhawa
OBJECTIVE: To compare mean birth weights and gestational age at delivery of infants born to Indian, Pakistani, Bangladeshi and white British mothers in Luton, UK. DESIGN: Retrospective analysis using routinely recorded secondary data in Ciconia Maternity information System, between 2008 and 2013. SETTING: Luton, UK. PARTICIPANTS: Mothers whose ethnicity was recorded as white British, Bangladeshi, Pakistani or Indian and living in Luton, aged over 16, who had a live singleton birth over 24 weeks of gestation were included in the analysis (n=14 871)...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799164/preconception-care-for-diabetic-women-for-improving-maternal-and-infant-health
#13
REVIEW
Joanna Tieu, Philippa Middleton, Caroline A Crowther, Emily Shepherd
BACKGROUND: Infants born to mothers with pre-existing type 1 or type 2 diabetes mellitus are at greater risk of congenital anomalies, perinatal mortality and significant morbidity in the short and long term. Pregnant women with pre-existing diabetes are at greater risk of perinatal morbidity and diabetic complications. The relationship between glycaemic control and health outcomes for both mothers and infants indicates the potential for preconception care for these women to be of benefit...
August 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28798896/pregnancy-outcomes-in-hiv-infected-women-experience-from-a-tertiary-care-center-in-india
#14
Vatsla Dadhwal, Aparna Sharma, Kavita Khoiwal, Dipika Deka, Plaboni Sarkar, P Vanamail
BACKGROUND AND OBJECTIVES: There is conflicting data on the effect of HIV infection as well as antiretroviral therapy (ART) on pregnancy outcome. The objectives of this study were to compare pregnancy outcomes in women with and without HIV infection, and to evaluate the effect of HAART on pregnancy in HIV-infected women. METHODS: This is a prospective case record analysis of 212 HIV-infected women delivering between 2002 and 2015, in a tertiary health care center in India...
2017: International Journal of MCH and AIDS
https://www.readbyqxmd.com/read/28783802/association-of-neonatal-glycemia-with-neurodevelopmental-outcomes-at-4-5-years
#15
Christopher J D McKinlay, Jane M Alsweiler, Nicola S Anstice, Nataliia Burakevych, Arijit Chakraborty, J Geoffrey Chase, Gregory D Gamble, Deborah L Harris, Robert J Jacobs, Yannan Jiang, Nabin Paudel, Ryan J San Diego, Benjamin Thompson, Trecia A Wouldes, Jane E Harding
Importance: Hypoglycemia is common during neonatal transition and may cause permanent neurological impairment, but optimal intervention thresholds are unknown. Objective: To test the hypothesis that neurodevelopment at 4.5 years is related to the severity and frequency of neonatal hypoglycemia. Design, Setting, and Participants: The Children With Hypoglycemia and Their Later Development (CHYLD) Study is a prospective cohort investigation of moderate to late preterm and term infants born at risk of hypoglycemia...
August 7, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28780218/predicting-the-risk-of-macrosomia-at-mid-pregnancy-among-non-diabetics-a%C3%A2-retrospective-cohort-study
#16
Elizabeth Jeffers, Linda Dodds, Victoria Allen, Christy Woolcott
OBJECTIVE: To identify factors known in mid-pregnancy to be associated with risk of macrosomia (≥4000 g) among non-diabetic women and to develop a risk score to allow early identification of women at high risk. METHODS: Data were obtained from a population-based perinatal database and a hospital laboratory database in Nova Scotia, Canada. The study included singleton live births born to non-diabetic women between 1998 and 2005. Logistic regression was used to identify risk factors significantly associated with macrosomia...
August 2, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28776916/the-association-of-breastfeeding-with-insulin-resistance-at-17%C3%A2-years-prospective-observations-from-hong-kong-s-children-of-1997-birth-cohort
#17
Lai Ling Hui, Man Ki Kwok, E Anthony S Nelson, So Lun Lee, Gabriel M Leung, C Mary Schooling
Breastfeeding has many benefits for mother and infant. Whether breastfeeding also protects against type 2 diabetes is unclear. To clarify the role of breastfeeding in type 2 diabetes, we assessed the association of breastfeeding with insulin resistance in late adolescence in a birth cohort from a non-Western setting where breastfeeding was not associated with higher socio-economic position. We used multivariable linear regression, with multiple imputation and inverse probability weighting, to examine the adjusted associations of contemporaneously reported feeding in the first 3 months of life (exclusively breastfed, mixed feeding, or always formula-fed) with fasting glucose, fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) at 17 years in a subset (n = 710, 8...
August 4, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28771289/screening-for-gestational-diabetes-mellitus-based-on-different-risk-profiles-and-settings-for-improving-maternal-and-infant-health
#18
REVIEW
Joanna Tieu, Andrew J McPhee, Caroline A Crowther, Philippa Middleton, Emily Shepherd
BACKGROUND: Gestational diabetes mellitus (GDM) is a form of diabetes that occurs in pregnancy. Although GDM usually resolves following birth, it is associated with significant morbidities for mothers and their infants in the short and long term. There is strong evidence to support treatment for GDM. However, there is uncertainty as to whether or not screening all pregnant women for GDM will improve maternal and infant health and if so, the most appropriate setting for screening. This review updates a Cochrane Review, first published in 2010, and subsequently updated in 2014...
August 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28768549/intranasal-insulin-reverts-central-pathology-and-cognitive-impairment-in-diabetic-mother-offspring
#19
Juan Jose Ramos-Rodriguez, Daniel Sanchez-Sotano, Alberto Doblas-Marquez, Carmen Infante-Garcia, Simon Lubian-Lopez, Monica Garcia-Alloza
BACKGROUND: Adverse effects in diabetic mothers offspring (DMO) are a major concern of increasing incidence. Among these, chronic central complications in DMO remain poorly understood, and in extreme cases, diabetes can essentially function as a gestational brain insult. Nevertheless, therapeutic alternatives for DMO are limited. METHODS: Therefore, we have analyzed the central long-term complications in the offspring from CD1 diabetic mothers treated with streptozotozin, as well as the possible reversion of these alterations by insulin administration to neonates...
August 2, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28764828/the-infant-born-to-a-woman-with-gestational-diabetes
#20
Theresa Povinelli, Caitlin Lim, Deborah A Raines
Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset during pregnancy. During pregnancy, women with GDM develop insulin resistance, which results in altered glucose tolerance. As a result, there are frequent episodes of hyperglycemia and high levels of circulating amino acids, increasing the transfer of nutrients to the fetus. This article discusses the role of the mother-baby nursing in the care of neonates born to women with gestational diabetes.
July 1, 2017: Neonatal Network: NN
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