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allergy cow's milk

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https://www.readbyqxmd.com/read/28934137/evidence-for-involvement-of-il-9-and-il-22-in-cows-milk-allergy-in-infants
#1
Karina V Barros, Vera L Flor Silveira, Marisa S Laranjeira, Neusa F Wandalsen, Susana Passeti, Roberta de Oliveira, Regina V Munekata, Paul S Noakes, Elizabeth A Miles, Philip C Calder
Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20)...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28925556/national-allergy-programme-had-little-impact-on-parent-reported-food-allergies-in-children-aged-6-7-years
#2
Sauli Palmu, Paula Heikkilä, Virpi Uski, Siina Niitty, Sari Kurikka, Matti Korppi
AIM: The ten-year Finnish national allergy programme was launched in 2008 to lessen the disease and psychological burden of allergy. This study assessed the prevalence of parent-reported food allergies requiring avoidance diets at primary school in children aged six and seven years. METHODS: The cohort comprised 1,937 children (51% boys) who started primary school in Tampere, Finland in August 2016. School health nurses charted parent-reported, doctor-diagnosed food allergies requiring avoidance diets as part of the routine health examination...
September 19, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28922259/gastrointestinal-symptoms-of-food-challenge-proven-non-ige-cow-s-milk-allergy-are-dissipated-by-early-school-age
#3
Noora Helin, Kaija-Leena Kolho, Erik Qvist, Mika Mäkelä, Laura Merras-Salmio
OBJECTIVES: To evaluate the current well-being and dietary restrictions in children six years after food challenge confirmed diagnosis of non-IgE cow's milk protein allergy, compared to peers with gastrointestinal symptoms but negative food challenge. To evaluate the diagnostic process retrospectively. METHODS: Internet-based survey for mothers whose children underwent six years ago the double-blind, placebo-controlled food challenge for cow's milk because of gastrointestinal symptoms causing suspicion of non-IgE cow's milk protein allergy...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28917235/reconfirmation-of-improved-tolerance-to-a-new-amino-acid-based-formula-by-infants-with-cow-s-milk-protein-allergy
#4
Pipop Jirapinyo, Narumon Densupsoontorn, Channagan Kangwanpornsiri, Renu Wongarn, Hathaichanok Tirapongporn, Kwanjai Chotipanang, Phakkanan Phuangphan
BACKGROUND AND OBJECTIVES: Reasons for intolerance to commercial amino acid-based formulas (cAAF) in infants diagnosed with cow's milk protein allergy (CMA) remain unknown. We assume that minute amounts of proteins, presenting in the glucose polymers derived from corn starch (cGPs), can elicit the intolerance to the cAAFs observed in some infants with CMA. By replacing cGPs with glucose polymers derived from rice starch (rGPs), a new amino acid-based (nAAF) formula has been shown to be better tolerated than an existing cAAF...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28885749/paediatric-food-induced-anaphylaxis-hospital-presentations-in-new-zealand
#5
Sophie Speakman, Bridget Kool, Jan Sinclair, Penny Fitzharris
AIM: Globally, rates of paediatric food-induced anaphylaxis (FIA) are increasing. Little data is available regarding the epidemiology of FIA among New Zealand (NZ) children. This study investigated the incidence of paediatric (0-14 years) FIA hospital presentations in NZ over a 10-year period. METHODS: Ministry of Health public hospital discharge data from 2006 to 2015 were analysed using FIA-related International Classification of Diseases codes (T78.0 - anaphylactic shock due to adverse food reaction and T78...
September 8, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28884988/assessment-of-allergen-specific-ige-by-immunoblotting-method-in-atopic-dermatitis
#6
M R Bonyadi, D Hassanzadeh, N Seyfizadeh, S Borzoueisileh
Background and Objectives. Stimulating the immune system by exposure to various allergens to produce specific IgE has a significant role in the pathogenesis of atopic dermatitis. Identifying disease-causing allergens, prevention of exposure to those allergens, and immunotherapy will play an important role in the treatment of Atopic Disease. The purpose of this study was to determine the common allergens of northwest of Iran in patients with atopic dermatitis that are resistant to treatment. Materials and methods...
September 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28875884/residual-allergenicity-of-amino-acid-based-and-extensively-hydrolysed-cow-s-milk-formulas
#7
M E Levin, D M Blackhurst, F Kirstein, D Kok, G F Van der Watt, A D Marais
BACKGROUND: Criteria for labelling infant feeds as suitable for the dietary management of cow's milk protein allergy (CMPA) rely on proving the hypoallergenicity of such feeds or clinical studies showing that the feeds are tolerated by 90% of children with proven CMPA. South African (SA) labelling legislation does not indicate what testing is necessary to prove hypoallergenicity. OBJECTIVES: To evaluate all extensively hydrolysed cow's milk formulas and amino acid-based formulas available in SA for residual allergen content, protein size and amino-acid content...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28866384/intestinal-microbiota-in-infants-at-high-risk-for-allergy-effects-of-prebiotics-and-role-in-eczema-development
#8
Harm Wopereis, Kathleen Sim, Alexander Shaw, John O Warner, Jan Knol, J Simon Kroll
BACKGROUND: The development of gut microbiota in infancy is important in the maturation of the immune system. Deviations in colonization patterns have been associated with allergic manifestations (e.g. eczema), but exact microbiome dysfunctions underlying allergies remain unclear. We studied the gut microbiota of 138 infants at increased risk of developing allergy, participating in a clinical trial investigating the effectiveness of a partially hydrolyzed protein formula supplemented with non-digestible oligosaccharides (pHF-OS) on the prevention of eczema...
August 30, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28858242/effect-of-processing-intensity-on-immunologically-active-bovine-milk-serum-proteins
#9
Tabea Brick, Markus Ege, Sjef Boeren, Andreas Böck, Erika von Mutius, Jacques Vervoort, Kasper Hettinga
Consumption of raw cow's milk instead of industrially processed milk has been reported to protect children from developing asthma, allergies, and respiratory infections. Several heat-sensitive milk serum proteins have been implied in this effect though unbiased assessment of milk proteins in general is missing. The aim of this study was to compare the native milk serum proteome between raw cow's milk and various industrially applied processing methods, i.e., homogenization, fat separation, pasteurization, ultra-heat treatment (UHT), treatment for extended shelf-life (ESL), and conventional boiling...
August 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28857182/altered-mir-193a-5p-expression-in-children-with-cow-s-milk-allergy
#10
Valeria D'Argenio, Valentina Del Monaco, Lorella Paparo, Fatima Domenica Elisa De Palma, Rita Nocerino, Francesca D'Alessio, Feliciano Visconte, Valentina Discepolo, Luigi Del Vecchio, Francesco Salvatore, Roberto Berni Canani
BACKGROUND: Cow's milk allergy (CMA) is one of the most common food allergies in children. Epigenetic mechanisms have been suggested to play a role in CMA pathogenesis. We shown that DNA methylation of Th1/Th2 cytokine genes and FoxP3 affects CMA disease course. Preliminary evidence suggest that also the miRNome could be implicated in the pathogenesis of allergy. Main study outcome was to comparatively evaluate miRNome in children with CMA and in healthy controls. METHODS: Peripheral blood mononuclear cells were obtained from children aged 4-18 months: 10 CMA patients, 9 CMA patients who outgrew CMA, and 11 healthy controls...
August 30, 2017: Allergy
https://www.readbyqxmd.com/read/28852472/better-recognition-diagnosis-and-management-of-non-ige-mediated-cow-s-milk-allergy-in-infancy-imap-an-international-interpretation-of-the-map-milk-allergy-in-primary-care-guideline
#11
REVIEW
Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M Fleischer, Ralf G Heine, Michael Levin, Mario C Vieira, Adam T Fox
Cow's milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood. It is also one of the most complex food allergies, being implicated in IgE-mediated food allergy as well as diverse manifestations of non-IgE-mediated food allergy. For example, gastrointestinal CMA may present as food protein induced enteropathy, enterocolitis or proctocolitis. Concerns regarding the early and timely diagnosis of CMA have been highlighted over the years. In response to these, guideline papers from the United Kingdom (UK), Australia, Europe, the Americas and the World Allergy Organisation have been published...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28825866/immunotherapy-for-cow-s-milk-allergy
#12
Shoichiro Taniuchi, Masaya Takahashi, Kazukiko Soejima, Yasuko Hatano, Hirotaka Minami
Oral immunotherapy (OIT) is used regularly for young children with cow's milk (CM) allergy and has been shown to be effective in several studies. However, adverse events occur frequently during OIT. Furthermore, there are only five randomized controlled trial studies of CM-OIT and these are low-powered single center trials. Therefore, evidence levels are also low and sometimes frequent and severe allergic events occur during the OIT. Furthermore, there are no standardized protocols in pediatric allergy guidelines from several countries and studies with long-term follow-up observations and clinical tolerance defined as sustained unresponsiveness are rare...
August 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28781718/a-partially-hydrolyzed-100-whey-formula-and-the-risk-of-eczema-and-any-allergy-an-updated-meta-analysis
#13
REVIEW
Hania Szajewska, Andrea Horvath
BACKGROUND: Recently, the role of using hydrolyzed formula for the prevention of allergic disease has been questioned. However, not all hydrolyzed formulas are equal. The efficacy of each hydrolyzed formula should be established separately. We updated evidence on the effectiveness of using partially hydrolyzed 100% whey formula (pHF), manufactured by a single manufacturer, for reducing the risk of eczema and allergy in healthy infants at high risk for allergy. METHODS: The Cochrane Library, MEDLINE, and EMBASE databases were searched in June 2016 for randomized and quasi-randomized controlled trials (RCTs); additional data were obtained from reviewed articles and the authors of included trials...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28759641/novel-sensitive-monoclonal-antibody-based-competitive-enzyme-linked-immunosorbent-assay-for-the-detection-of-raw-and-processed-bovine-beta-casein
#14
Daniela S Castillo, Alejandro Cassola
Cow milk protein allergy (CMPA) is the most common childhood food allergy, which can sometimes persist or can newly develop in adulthood with severe symptoms. CMPA's treatment is complete dietary avoidance of milk proteins. To achieve this task, patients have to be aware of milk proteins found as "hidden allergens" in food commodities. In regard to milk proteins, it has been reported that allergenicity of caseins remains unaffected upon heat treatment. For these reasons, we aimed to obtain monoclonal antibodies (mAbs) against native and denatured β-casein, one of the most abundant and antigenic caseins, in order to develop an indirect competitive ELISA (icELISA) to detect and quantify traces of this milk allergen in raw and processed foodstuffs...
2017: PloS One
https://www.readbyqxmd.com/read/28757143/methods-in-allergy-immunology-food-challenges
#15
EDITORIAL
Barbara K Ballmer-Weber, Kirsten Beyer
Since there is no in vitro test, which can accurately predict the clinical relevance of a sensitization to food, the oral food challenge still remains the most reliable procedure to confirm or exclude food allergy and to assess the development of tolerance in children with potentially transient food allergies such as to cow's milk, hen's egg, wheat or soy. Although in the last few years component-resolved diagnostic has improved the food allergy diagnostics, especially in peanut and tree nut allergy, the majority of patients still need to undergo oral food challenge...
July 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28739021/single-and-multiple-food-allergies-in-infants-with-proctocolitis
#16
B T Koksal, Z Barıs, F Ozcay, O Yilmaz Ozbek
BACKGROUND: Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined. OBJECTIVE: This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies. METHODS: A total of 132 infants with proctocolitis were evaluated retrospectively. All of the infants were diagnosed by a paediatric allergist and/or a paediatric gastroenterologist according to guidelines...
July 21, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28737860/natural-history-of-immunoglobulin-e-mediated-cow-s-milk-allergy-in-a-population-of-argentine-children
#17
Natalia A Petriz, Claudio As Parisi, Julio N Busaniche, Patricia Evangelista, Romina Mehaudy, Marina Orsi
INTRODUCTION: Cow's milk protein allergy is the most common allergy in pediatrics. Immunoglobulin E (IgE)-mediated cow's milk allergy poses a higher risk for life and a worse prognosis. OBJETIVES: To describe the course of IgE-mediated cow's milk protein allergy and risk factors associated with disease persistence. PATIENTS AND METHODS: This was a descriptive, retrospective study conducted in patients seen at the Division of Pediatric Allergy of Hospital Italiano between June 2006 and June 2012 who had been diagnosed with IgE-mediated cow's milk allergy...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28732431/the-efficacy-of-oral-immunotherapy-in-patients-with-cow-s-milk-allergy
#18
Mohsen Ebrahimi, Mohammad Gharagozlou, Ali Mohebbi, Nasim Hafezi, Gholamreza Azizi, Masoud Movahedi
Cow's milk allergy is the most common type of food allergy that decrease the quality of life of patients and their families. The aim of this study was to evaluate the efficacy of oral immunotherapy in patients with cow's milk allergy. 14 patients above 3 years of age with a history of cow's milk allergy confirmed by positive double blind placebo controlled food challenge (DBPCFC) test, presence of serum IgE against cow's milk and positive SPT (skin prick test) were enrolled in this study. During the immunotherapy all patients received increasing amounts of cow's milk during three phases...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28731550/food-allergy-in-schools-the-importance-of-government-involvement
#19
Tanya Lawlis, Sarah Bakonyi, Lauren T Williams
AIM: Children have the highest rates of food-related allergic reactions. While 85% of children outgrow allergies including cow's milk and eggs by five years of age, allergies to peanuts and seafood continue into adulthood. The school setting poses a high-risk environment for allergen exposure. The aim of the present study was to examine the availability, drivers and communication of school food allergy awareness and management policies/guidelines in one Australian education jurisdiction...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731411/oral-immunotherapy-for-food-allergy-a-spanish-guideline-immunotherapy-egg-and-milk-spanish-guide-items-guide-part-i-cow-milk-and-egg-oral-immunotherapy-introduction-methodology-rationale-current-state-indications-contraindications-and-oral-immunotherapy-build
#20
REVIEW
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. METHODS: A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC...
2017: Journal of Investigational Allergology & Clinical Immunology
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