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https://www.readbyqxmd.com/read/29772406/fertility-pregnancy-and-clinical-outcomes-after-uterine-arteriovenous-malformation-management
#1
Sophie Delplanque, Maela Le Lous, Maïa Proisy, Yolaine Joueidi, Estelle Bauville, Celine Rozel, Eugénie Beraud, Bertrand Bruneau, Jean Levêque, Vincent Lavoué, Krystel Nyangoh Timoh
STUDY OBJECTIVE: To evaluate fertility, pregnancy, and clinical outcomes after uterine arteriovenous malformation (UAVM) management. DESIGN: Single-center retrospective study from January 2000 to July 2017. (Canadian task force III). SETTING: One referral center. PATIENTS: Twenty-two patients with a UAVM diagnosed by Magnetic Resonance Angiography (MRA) or Computed Tomography (CT) angiography and managed by Expectant Management (EM) or Uterine Arterial Embolization (UAE) during the study period were included...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29769344/efficient-delivery-of-hcmv-t-cell-antigens-by-attenuated-sendai-virus-vectors
#2
Richard Kiener, Markus Fleischmann, Marian Alexander Wiegand, Niels A W Lemmermann, Christiane Schwegler, Christine Kaufmann, Angelique Renzaho, Simone Thomas, Eva Felder, Hans Helmut Niller, Benedikt Asbach, Ralf Wagner
Human Cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression and the licensing of a protective HCMV vaccine remains an unmet global need. Herein, we designed and validated novel Sendai virus (SeV) vectors delivering T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a non-productive manner while retaining viral gene expression. In this study, we explored the impact that transduction with rdSeV has on human dendritic cells (DCs) by comparing it to the parental, replication-competent Sendai virus strain (rcSeV) as well as the poxvirus strain Modified Vaccinia Ankara (MVA)...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29767691/thyroid-hormones-and-female-reproduction
#3
Juneo F Silva, Natália M Ocarino, Rogéria Serakides
Thyroid hormones are vital for the proper functioning of the female reproductive system, since they modulate the metabolism and development of ovarian, uterine and placental tissues. Therefore, hypo- and hyperthyroidism may result in subfertility or infertility in both women and animals. Other well-documented sequelae of maternal thyroid dysfunctions include menstrual/estral irregularity, anovulation, abortion, preterm delivery, preeclampsia, intrauterine growth restriction, postpartum thyroiditis, and mental retardation in children...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29757875/surgery-and-platinum-etoposide-based-chemotherapy-for-the-treatment-of-epithelioid-trophoblastic-tumor
#4
Janelle Sobecki-Rausch, Abigail Winder, Kruti P Maniar, Anna V Hoekstra, Emily Berry, Karen Novak, John R Lurain
OBJECTIVE: Epithelioid trophoblastic tumor (ETT) is a rare variant of gestational trophoblastic neoplasia that develops from chorionic-type intermediate trophoblast, simulates carcinoma, presents years after a pregnancy event, is associated with low or normal human chorionic gonadotropin levels, and is relatively resistant to chemotherapy. Our aim was to identify the role of surgery in combination with platinum/etoposide-based chemotherapy in the management of both localized and metastatic ETT...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29752204/medication-abortion-potential-for-improved-patient-access-through-pharmacies
#5
Sarah Raifman, Megan Orlando, Sally Rafie, Daniel Grossman
OBJECTIVES: To discuss the potential for improving access to early abortion care through pharmacies in the United States. SUMMARY: Despite the growing use of medications to induce termination of early pregnancy, pharmacist involvement in abortion care is currently limited. The Food and Drug Administration's Risk Evaluation and Mitigation Strategy (REMS) for Mifeprex® (mifepristone 200 mg), the principal drug used in early medication abortion, prohibits the dispensing of the drug by prescription at pharmacies...
May 8, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29745913/benefits-of-early-screening-and-proper-treatment-in-patient-with-significant-risk-factors-for-gestational-diabetes-mellitus-case-report
#6
V Limani
Gestational diabetes mellitus (GDM) occurs in 2-9% of all pregnancies. Evidence suggests that the use of insulin in treating hyperglycemia in GDM patients reduces the risk of perinatal morbidity. Pregnancy is an exciting time in a woman's life. However, once patient is diagnosed with GDM, she will be managed more intensively. GDM is managed using diet and exercise but one in six women with GDM requires insulin. A 35-year-old woman at the 14th gestational week of her tenth pregnancy was seen for routine prenatal care...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29742294/risk-factors-for-self-reported-postpartum-hemorrhage-in-ga-east-ghana
#7
Viviane Valdes, Philip B Adongo, Adanna U Nwameme, Philip T N Tabong, Michelle Fernandes
OBJECTIVE: To document the prevalence of self-reported postpartum hemorrhage (PPH) in Ga East, Accra, Ghana, and examine the demographic, biological, and social risk factors for PPH. METHODS: The present study was a cross-sectional secondary analysis of data collected during 2010-2012 from the Ghana Essential Health Interventions Program, a quasi-experimental interventional study surveying households in the urban Ga East Municipal District. The analysis included data from randomly selected parous women of childbearing age (15-49 years), excluding those with a history of abortion (spontaneous or induced) or stillbirth...
May 9, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29739005/smoking-exposure-in-early-pregnancy-and-adverse-pregnancy-outcomes-usefulness-of-urinary-tobacco-specific-nitrosamine-metabolite-4-methylnitrosamino-1-3-pyridyl-1-butanol-levels
#8
Si Won Lee, You Jung Han, Dong Hee Cho, Ho-Seok Kwak, Kinarm Ko, Mi Hye Park, Jung Yeol Han
OBJECTIVES: The aim was to investigate the effect of -maternal smoking exposure assessed by urinary tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-a1-butanol (NNAL) with adverse pregnancy outcomes. METHODS: A total of 251 pregnant women were recruited. Urinary cotinine and NNAL were measured. Participants' sociodemographics were obtained by questionnaire and pregnancy outcomes were collected by charts review after delivery. RESULTS: The prevalence of smoking was 8...
May 8, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29730033/incidence-and-biomarkers-of-pregnancy-spontaneous-abortion-and-neonatal-loss-during-an-environmental-stressor-implications-for-female-reproductive-suppression-in-the-cooperatively-breeding-meerkat
#9
Kristin A Dimac-Stohl, Charli S Davies, Nicholas M Grebe, Alexandra C Stonehill, Lydia K Greene, Jessica Mitchell, Tim Clutton-Brock, Christine M Drea
Meerkats are group-living, insectivorous herpestids in which subordinate members provide extensive care for the dominant female's young. In contrast to some cooperative breeders, subordinate female meerkats are physiologically able to reproduce and occasionally do so successfully; their attempts are more frequently 'suppressed' via eviction or infanticide by the dominant female. Spontaneous abortion and neonatal loss occur with some regularity, further negatively impacting reproductive success. Here, we compared the reproductive outcomes and endocrine profiles, including of serum progesterone (P4 ), serum estradiol (E2 ), and fecal glucocorticoid metabolites (fGCm), of dominant and subordinate dams residing within their clans in the Kalahari Desert of South Africa...
May 2, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29701867/pregnancy-complications-associated-with-maternal-hypothyroidism-a-systematic-review
#10
Danielle Rosani Shinohara, Thais da Silva Santos, Hayalla Corrêa de Carvalho, Laíza Cristina Bahls Lopes, Luciene Setsuko Akimoto Günther, Sandra Mara Alessi Aristides, Jorge Juarez Vieira Teixeira, Izabel Galhardo Demarchi
Importance: Hypothyroidism is one of the most prevalent diseases in pregnancy, but there is no consensus about its management in pregnant women. Objective: In this systematic review, we evaluated the association between pregnancy complications and treated or untreated maternal hypothyroidism. Evidence Acquisition: PubMed and reference lists were searched for the Medical Subject Headings terms "pregnancy complications" and "hypothyroidism...
April 2018: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29692487/ectopic-pregnancy-review-of-80-cases
#11
S K Kathpalia, D Arora, Namrita Sandhu, Pooja Sinha
Background: Ectopic pregnancy or extrauterine pregnancy will invariably result in abortion or rupture. Though there are risk factors for ectopic pregnancy, but at times the condition can occur without any apparent predisposing factor. Cases admitted with provisional diagnosis of ectopic pregnancy were included in this prospective study. Methods: Eighty suspected cases of ectopic pregnancy were incorporated in the study. The management was done based on standard practice...
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29681079/abortion-law-reform-why-ethical-intractability-and-maternal-morbidity-are-grounds-for-decriminalisation
#12
Andrew McGee, Melanie Jansen, Sally Sheldon
In this paper, we present two grounds for arguing that abortion should be decriminalised. First, we consider the implications of the fact that the long-standing ethical debate concerning the morality of abortion has to date proven intractable. We maintain that because the philosophical literature has failed to demonstrate conclusively that views either for or against abortion's moral acceptability are false, the matter remains at a stalemate in terms of rational debate, contributing to the ongoing absence of political and popular consensus about the issue in our society...
April 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29680767/outcomes-of-dilation-and-evacuation-with-and-without-feticide-by-intra-cardiac-potassium-chloride-injection-a-service-evaluation
#13
Patricia A Lohr, John H Parsons, Jeanette Taylor, Chelsea Morroni
OBJECTIVE: To compare procedure duration, complications, and acceptability of dilation and evacuation (D&E) with and without feticide by intra-cardiac potassium chloride (KCL) injection. STUDY DESIGN: We evaluated outcomes with D&E at 18-24weeks' gestation in the 6months before and 6months after removing feticide with KCL from the guidelines of a national British abortion provider. We extracted demographic and procedure-related data from medical records and electronic databases...
April 19, 2018: Contraception
https://www.readbyqxmd.com/read/29668583/a-prisma-systematic-review-and-meta-analysis-on-chlamydia-trachomatis-infections-in-iranian-women-1986-2015
#14
Daem Roshani, Rashid Ramazanzadeh, Fariba Farhadifar, Amjad Ahmadi, Safoura Derakhshan, Samaneh Rouhi, Shamsi Zarea, Farnaz Zandvakili
BACKGROUND: Chlamydia trachomatis (CT) is the cause of genital tract infections in women. Some evidence has shown the role of this infection with CT in spontaneous abortions. The purpose of this study is to study the frequency of CT infection in Iranian women. METHODS: This study was performed based on PRISMA guidelines. A total of 75 articles published in Google Scholar, PubMed, ISI Web of Science, Biological abs, Iranmedex, SID, and Scopus databases were found (1986-2015) using the following keywords: CT in women, CT and Iranian women, CT and infection in Iran, CT and pregnancy in Iran, CT and preterm delivery in Iran, CT and preterm labor in Iran, CT and fertility in Iran, CT and infertility in Iran, and CT and abortion in Iran...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29661199/adverse-pregnancy-outcomes-in-adolescents-and-young-women-with-systemic-lupus-erythematosus-a-national-estimate
#15
Nicole Ling, Erica Lawson, Emily von Scheven
BACKGROUND: Pregnant women with systemic lupus erythematosus (SLE) have increased risk of adverse outcomes including disease flare, spontaneous abortion, preeclampsia/eclampsia, premature birth and maternal death. However, pregnancy outcomes among adolescents and young women with SLE have not been well-explored. Our objective was to compare risk of adverse pregnancy outcomes in adolescents and young women with SLE to risk among peers without SLE. METHODS: We studied the 2000-2011 Nationwide Inpatient Sample (NIS) of the Healthcare Cost and Utilization Project (HCUP) to estimate the prevalence of adverse pregnancy outcomes in women with SLE aged ≤ 21 years at time of delivery...
April 16, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29658450/-influence-of-acute-pancreatitis-in-pregnancy-on-pregnancy-outcomes-and-neonates
#16
Shu-Juan Fan, Jun-Xi Xiang, Mi Xiao, Fang-Hui Wang, Xiao-Jie Lin, Xi-Hui Zhou, Ting Ai, Li Liu
OBJECTIVE: To study the influence of acute pancreatitis in pregnancy (APIP) on pregnancy outcomes and neonates. METHODS: A retrospective analysis was performed for 33 APIP patients and 31 neonates born alive. RESULTS: Of the 33 APIP patients, 26 (79%) developed APIP in the late pregnancy. Fourteen (45%) patients had hyperlipidemic APIP, 13 (42%) had biliary APIP, and 4 (13%) had other types of APIP. According to the severity, 22 (67%) were mild APIP, 5 (15%) were moderate APIP, and 6 were severe APIP...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29644439/comparative-effects-of-antidepressant-medications-and-untreated-major-depression-on-pregnancy-outcomes-a-systematic-review
#17
REVIEW
Jentina Mitchell, Janice Goodman
Psychopharmacological treatment of pregnant women is an area of continued controversy; extensive observational research on the use of antidepressant medications in pregnancy has found these medications to be associated with increased risk of spontaneous abortion, preterm delivery, and low birth weight. However, depression itself has also been associated with increased risk of those same outcomes, and only recently have researchers begun trying to compare treated with untreated depression. The purpose of this study was to conduct a systematic review of the literature to integrate those comparative studies and compare risks and benefits...
April 11, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29627847/pregnancy-outcomes-and-superiorities-of-prophylactic-cervical-cerclage-and-therapeutic-cervical-cerclage-in-cervical-insufficiency-pregnant-women
#18
Yanyan Liu, Zikan Ke, Wanmin Liao, Hanping Chen, Shiqing Wei, Xiaoquan Lai, Xi Chen
PURPOSE: To compare the clinical effect of prophylactic cervical cerclage and therapeutic cervical cerclage on pregnancy outcome and operative factors in cervical insufficiency pregnant women. METHODS: A retrospective study was conducted between June 2014 and September 2016 in a maternity ward, which included women who have had a single pregnancy and have been carried out a McDonald cerclage. All maternal medical records were reviewed. The efficacy of cerclage for preventing late foetal loss was assessed using multivariable logistic regression analysis...
April 7, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29625509/adult-congenital-heart-disease-with-pregnancy
#19
REVIEW
Koichiro Niwa
The number of women with congenital heart disease (CHD) at risk of pregnancy is growing because over 90% of them are grown-up into adulthood. The outcome of pregnancy and delivery is favorable in most of them provided that functional class and systemic ventricular function are good. Women with CHD such as pulmonary hypertension (Eisenmenger syndrome), severe left ventricular outflow stenosis, cyanotic CHD, aortopathy, Fontan procedure and systemic right ventricle (complete transposition of the great arteries [TGA] after atrial switch, congenitally corrected TGA) carry a high-risk...
April 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29594007/heterotopic-interstitial-pregnancy-a-case-report
#20
Joy Anderson, Chase Patterson, April Riley
Introduction: Before the advent of assisted reproductive technologies, the incidence of heterotopic pregnancy was estimated to be in 1 out of 30,000 pregnancies in the United States. With interstitial pregnancy comprising only 2.4% of ectopic pregnancies, spontaneous heterotopic interstitial pregnancies are exceedingly rare. Case: A 27-year-old pregnant woman (gravida 3 para 1011) with a history of one prior term vaginal delivery and a spontaneous abortion in the first trimester presented to the emergency department with abdominal pain and a positive home pregnancy test...
January 2018: Case Reports in Women's Health
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