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https://www.readbyqxmd.com/read/28801981/pregnancy-outcomes-in-mothers-of-offspring-with-inherited-bone-marrow-failure-syndromes
#1
Neelam Giri, Helen D Reed, Pamela Stratton, Sharon A Savage, Blanche P Alter
BACKGROUND: Children with inherited bone marrow failure syndromes (IBMFSs) may be symptomatic in utero, resulting in maternal and fetal problems during the pregnancy. Subsequent pregnancies by their mothers should be considered "high risk". METHODS: We retrospectively analyzed outcomes of 575 pregnancies in 165 unaffected mothers of offspring with Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond-Blackfan anemia (DBA), and Shwachman-Diamond syndrome (SDS) for events noted during pregnancy, labor, and delivery...
August 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28798930/adverse-pregnancy-outcomes-of-patients-with-history-of-first-trimester-recurrent-spontaneous-abortion
#2
Jing Yang, Yan Wang, Xiao-Ye Wang, Yan-Yu Zhao, Jing Wang, Yang-Yu Zhao
Although a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of subsequent pregnancy outcome is not clearly elucidated. Here, a retrospective analysis was performed on the clinical data of 492 singleton pregnant women. 164 of them with the history of FRSA were enrolled in study group, compared to 328 deliveries without the history of FRSA. For maternal outcomes, patients in the study group delivered earlier with mean gestational age and the incidences of cesarean section and postpartum hemorrhage were higher compared to the control group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28797671/pregnancy-after-bariatric-surgery-the-effect-of-time-to-conception-on-pregnancy-outcomes
#3
Patricia O Yau, Manish Parikh, John K Saunders, Patricia Chui, Tara Zablocki, Akuezunkpa Ude Welcome
BACKGROUND: At our medical center, female patients who have undergone bariatric surgery are advised to defer pregnancy for 2 years after surgery to avoid the following complications and their potential consequences for the fetus: inadequate gestational weight gain, inadequate postsurgical weight loss, hyperemesis gravidarum, nutritional deficiencies, gestational diabetes, and gestational hypertension. OBJECTIVES: To examine the effect of time from surgery to conception on pregnancy course and outcomes in bariatric patients...
July 17, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28768550/abuse-and-disrespect-in-childbirth-process-and-abortion-situation-in-latin-america-and-the-caribbean-systematic-review-protocol
#4
Sofia Madeira, Vicky Pileggi, João Paulo Souza
BACKGROUND: Studies show that a large number of women around the world have experienced situations of abuse, disrespect, abuse, and neglect during childbirth and/or abortion. This violence is a serious violation of the rights of women, especially because it is a period in which the woman is more physiologically, socially, and psychologically vulnerable. Although this type of violence is known, there is still no international consensus on the definition of such violence and its prevalence is not known...
August 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28766989/sixty-years-in-psychiatry
#5
John Bradley
The author, who has spent over 60 years working in a variety of mental health settings, shares his personal perspective of the way psychiatry has evolved. Treatments, both physical and psychological, have come and some have been discarded. There have been radical changes in the delivery of care, from the 2000-bed Victorian asylum to community care, and the on the whole beneficial impact of legislation such as mental health Acts and Acts dealing with suicide, abortion and sexual offences. His experience has warned him of the folly of overenthusiasm for some treatments - such as deep insulin for schizophrenia, psycho surgery, and even classical psychoanalysis which can become as addictive as any drug or a promise of salvation as convincing as a religion...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28761227/acute-kidney-injury-in-pregnancy-specific-disorders
#6
REVIEW
J Prakash, V C Ganiger
The incidence of acute kidney injury in pregnancy (P-AKI) has declined significantly over the last three decades in developing countries. However, it is still associated with significant fetomaternal mortality and morbidity. The diagnosis of P-AKI is based on the serum creatinine increase. The usual formulas for estimating glomerular filtration rate (GFR) are not validated in this population. The incidence of P-AKI with respect to total AKI cases has decreased in the last three decades from 25% in 1980s to 9% in 2000s at our centre...
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28758416/pregnancy-outcome-after-anti-migraine-triptan-use-a-prospective-observational-cohort-study
#7
Kevin Spielmann, Angela Kayser, Evelin Beck, Reinhard Meister, Christof Schaefer
Objective The objective of our study is to assess the impact of triptan exposure on pregnancy outcome. Methods We performed a prospective observational cohort study with 432 pregnant women exposed to triptans and enrolled by the German Embryotox system. Pregnancy outcomes were compared with a migraine and a non-migraine comparison cohort. Primary objectives were major birth defects and spontaneous abortion; secondary endpoints were preterm delivery, birth weight, pregnancy complications and the rate of electively terminated pregnancies...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28756529/risk-of-preterm-birth-and-low-birthweight-following-consecutive-surgical-and-medical-abortions
#8
Noah Zafran, Marian Musa, Sivan Zuarez-Easton, Gali Garmi, Shabtai Romano, Raed Salim
PURPOSE: To examine the effect of consecutive surgical compared to medical uterine evacuations on spontaneous preterm birth (SPTB) and low birthweight (LBW) rates in the immediate subsequent delivery. METHODS: Retrospective study, conducted at a teaching hospital on data from January 2000 to March 2016. First study group consisted of all women who had ≥2 consecutive medical evacuations (ME-Group); second study group consisted of women who had ≥2 consecutive surgical evacuations (SE-Group)...
July 29, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28754161/a-cross-sectional-study-of-maternal-near-miss-and-mortality-at-a-rural-tertiary-centre-in-southern-nigeria
#9
Ikechukwu Innocent Mbachu, Chukwuemeka Ezeama, Kelechi Osuagwu, Osita Samuel Umeononihu, Chibuzor Obiannika, Nkeiru Ezeama
BACKGROUND: The study evaluated the pattern of severe maternal outcome, near miss indicators and associated patient and healthcare factors at a private referral hospital in rural Nigeria. METHODS: This was a cross sectional study conducted from September 2014 to August 2015 in Madonna University Teaching Hospital Elele, Rivers State, Nigeria. Pregnant and postpartum women were recruited for the study using Nigeria near miss network proforma which was adopted from the WHO near miss proforma...
July 28, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28753654/medical-treatment-of-second-trimester-fetal-miscarriage-a-retrospective-analysis
#10
Maarit Niinimäki, Maarit Mentula, Reetta Jahangiri, Jaana Männistö, Annina Haverinen, Oskari Heikinheimo
OBJECTIVES: Research on the treatment of second-trimester miscarriages is scarce. We studied the outcomes, and the factors associated with adverse events and need for hospital resources in the medical treatment of second-trimester miscarriage. MATERIALS AND METHODS: In these retrospective analyses we studied women treated for spontaneous fetal miscarriage with misoprostol-only (n = 24) or mifepristone and misoprostol (n = 177) in duration of gestation 12+1-21+6...
2017: PloS One
https://www.readbyqxmd.com/read/28742214/association-of-combined-gif290t-c-heterozygous-mutation-fut2-secretor-variant-with-neural-tube-defects
#11
R M Guéant-Rodriguez, C Chery, B-M Fofou-Caillierez, J Voirin, B Foliguet, T Josse, D Tramoy, F François, J-L Guéant
Folate and vitamin B12 are needed for the proper embryo-fetal development possibly through their interacting role in the one-carbon metabolism. Folate fortification reduces the prevalence of complex birth defects, and more specifically neural tube defects (NTD). GIF and FUT2 are two genes associated with the uptake and blood level of vitamin B12. We evaluated GIF and FUT2 as predictors of severe birth defects, in 181 aborted fetuses compared to 375 healthy newborns. The GIF290C allele frequency was estimated to 0...
July 25, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28737125/taxanes-in-combination-with-platinum-derivatives-for-the-treatment-of-ovarian-cancer%C3%A2-during-pregnancy-a-literature-review%C3%A2
#12
Xiaoling Zheng, Yao Zhu, Yunchun Zhao, Shisen Feng, Caihong Zheng
Ovarian cancer is one of the most common types of solid carcinoma diagnosed during pregnancy. Taxane plus a platinum derivative is a combination therapy that is predominantly used in the treatment of ovarian cancer in non-pregnant women. Pregnancy adds various complexities to a course of treatment. In pregnant patients diagnosed with cancer during the first trimester, the risks of fetal malformations and fetal loss increase following the administration of cytotoxic drugs, and this is higher with multi-agent vs...
July 24, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28723858/maternal-hepatitis-b-virus-infection-and-pregnancy-outcomes-a-hospital-based-case-control-study-in-wuhan-china
#13
Zhihua Wan, Aifen Zhou, Huiping Zhu, Xiaofang Lin, Dan Hu, Songxu Peng, Bin Zhang, Yukai Du
GOALS: To examine the impact of maternal hepatitis B virus infection on pregnancy outcomes. BACKGROUND: Studies regarding hepatitis B virus infection and pregnancy outcomes are limited with inconsistent results, and none of them have evaluated the effect of maternal viral load in pregnancy on pregnancy outcomes. STUDY: A hospital-based case-control study was conducted. In total, 1728 hepatitis B surface antigen (HBsAg)-positive women who delivered consecutively at Wuhan Women and Children Medical and Healthcare Center, Wuhan, China, from June 2008 to May 2015, were compared with 1497 HBsAg-negative women giving birth in the same hospital during the same period who were randomly identified and selected from the computerized medical record database in parallel...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28706366/gnrh-antagonist-cetrorelix-administration-before-hcg-for-protection-of-ovarian-hyperstimulation-syndrome
#14
Sherif A Hebisha, Banan A Aboelazm, H N Sallam
OBJECTIVE: Studying the effect of GnRH antagonist administration on the day of hCG to cases of IVF/ICSI with estradiol level above 5000 ng/dl for protection of ovarian hyperstimulation syndrome. DESIGN: Prospective study. MATERIALS AND METHODS: Sixty patients undergoing controlled hyperstimulation COH, for IVF/ICSI using long agonist and E2 level on the day of hCG, are above 5000 ng/dl, 52 patients received single dose of cetrorelix 0.25 mg on the day of hCG, and 8 patients received two doses of 0...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28706365/obstetric-outcome-in-women-with-chronic-liver-disease
#15
Pinky Jena, C N Sheela, Rao Preethi Venkatachala, Harshad Devarbhavi
AIM: This study determines the prevalence, causes and outcome of pregnancy in women with chronic liver diseases in a tertiary level teaching institute in Southern India. METHODS: Retrospective analysis of case records was carried out between December 2010 and May 2015 in the departments of Obstetrics and Gynecology and Gastroenterology including pregnant women diagnosed to have chronic liver diseases prenatally or during pregnancy. RESULTS: The frequency of chronic liver disease in pregnancy was 50 among 10,823 deliveries (0...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28699189/human-papillomavirus-infects-placental-trophoblast-and-hofbauer-cells-but-appears-not-to-play-a-causal-role-in-miscarriage-and-preterm-labor
#16
Lea Maria Margareta Ambühl, Anne Katrine Leonhard, Carina Widen Zakhary, Annemette Jørgensen, Jan Blaakaer, Karen Dybkaer, Ulrik Baandrup, Niels Uldbjerg, Suzette Sørensen
INTRODUCTION: Recently, an association between human papillomavirus (HPV) infection and both spontaneous abortion and spontaneous preterm delivery was suggested. However, the reported HPV prevalence in pregnant women varies considerably and reliable conclusions are difficult. We aimed to investigate HPV infection in placental tissue of a Danish study cohort. Furthermore, we studied the cellular localization of HPV. MATERIAL AND METHODS: In this prospective case-control study, placental tissue was analyzed for HPV infection by nested PCR in the following four study groups: full-term delivery (n=103), spontaneous preterm delivery (n=69), elective abortion (n=54), and spontaneous abortion (n=44)...
July 12, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28698886/the-prevalence-subtypes-and-obstetric-risk-factors-of-urinary-incontinence-in-reproductive-age-women-referred-to-community-health-care-centers-of-dezful-iran-2015
#17
Roghaye Komeilifar, Nahid Javadifar, Poorandokht Afshari, Mohammad Hosein Haghighizade, Azam Honarmandpour
BACKGROUND: Urinary incontinence (UI) is a common health problem and has a profound effect on the quality of life and psychosocial aspects of the affected women. The aim of this study was to investigate the prevalence and risk factors of UI in reproductive age women. METHODS: This cross-sectional study was conducted on 2000 reproductive age women from February to June 2015. The women were selected from all of the primary health care centers of Dezful, using easy access sampling method...
July 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28690281/women-with-subclinical-hypothyroidism-are-at-low-risk-of-poor-pregnancy-outcome-in-japan
#18
Seishi Furukawa, Kazuko Miyakawa, Joichi Shibata, Mitsutoshi Iwashita
Maternal subclinical hypothyroidism may be associated with adverse pregnancy outcomes, although not consistently across regions. Here, we sought to determine the effect of elevated thyroid-stimulating hormone (TSH) on pregnancy outcomes in Japanese women without known medical complications. TSH was determined by dried blood spots at 8-20 weeks of gestation, and 3.0-10.0 μU/mL of TSH was considered as elevated TSH (eTSH). A retrospective study involving 167 cases of eTSH was conducted. Five hundred and seventy eight of controls with normal TSH and without thyroid antibodies were selected...
July 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28690279/towards-a-preventive-strategy-for-neosporosis-challenges-and-future-perspectives-for-vaccine-development-against-infection-with-neospora-caninum
#19
Yoshifumi Nishikawa
Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against infection with N. caninum. Because live and attenuated vaccines against N. caninum have had safety and effectiveness issues, development of a next-generation vaccine is urgently required. To develop a vaccine against neosporosis, my laboratory has been focused on the following: 1) understanding the host immune responses against Neospora infection, 2) identifying vaccine antigens and 3) developing an effective antigen-delivery system...
July 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28673342/knowledge-and-provision-of-misoprostol-among-pharmacy-workers-in-senegal-a-cross-sectional-study
#20
Kate Reiss, Katharine Footman, Eva Burke, Nafissatou Diop, Ramatoulaye Ndao, Babacar Mane, Maaike van Min, Thoai D Ngo
BACKGROUND: Making misoprostol widely available for management of postpartum haemorrhage (PPH) and post abortion care (PAC) is essential for reducing maternal mortality. Private pharmacies (thereafter called "pharmacies") are integral in supplying medications to the general public in Senegal. In the case of misoprostol, pharmacies are also the main supplier to public providers and therefore have a key role in increasing its availability. This study seeks to understand knowledge and provision of misoprostol among pharmacy workers in Dakar, Senegal...
July 3, 2017: BMC Pregnancy and Childbirth
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