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https://www.readbyqxmd.com/read/28318329/intact-parathyroid-hormone-levels-and-primary-hyperparathyroidism
#1
Haidar Al-Hraishawi, Peter J Dellatore, Xinjiang Cai, Xiangbing Wang
OBJECTIVE: The aim of this article is to compare clinical characteristics and lab values for metabolic syndrome between primary hyperparathyroidism (PHPT) patients with different levels of serum intact parathyroid hormone (iPTH) and to determine correlation between different clinical characteristics among PHPT patients Methods: We reviewed charts of 212 PHPT patients in this retrospective study. Patients were divided into two groups according to their initial serum iPTH levels. Student's t-tests were used to compare the two groups for differences in clinical characteristics and laboratory values...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28316315/current-indications-for-surgical-treatment-of-primary-hyperparathyroidism-in-the-elderly
#2
Andrea Polistena, Roberta Lucchini, Massimo Monacelli, Roberta Triola, Stefano Avenia, Ivan Barillaro, Louis Banka Johnson, Alessandro Sanguinetti, Nicola Avenia
This study presents the results of surgery in the elderly for primary hyperparathyroidism (PHPT) from a single institution's experience. We retrospectively analyzed 898 cases of surgically treated PHPT, divided into two groups: 135 elderly patients (A) and 763 patients younger than 65 years (B). PHPT was symptomatic in 68.8 per cent patients in group A and in 81.6 per cent in group B. Unilateral temporary recurrent laryngeal nerve palsy was observed in 0.9 per cent in group A and 0.1 per cent in group B (P > 0...
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28315908/positive-99m-tc-mibi-and-the-subtraction-parathyroid-scan-are-related-to-intact-parathyroid-hormone-but-not-to-total-plasma-calcium-in-primary-hyperparathyroidism
#3
Sanja Dugonjić, Marija Šišić, Marija Radulović, Boris Ajdinović
OBJECTIVE: Primary hyperparathyroidism (pHPT) is characterised by increased parathyroid hormone (PTH) secretion and consequently increased plasma calcium. During the last few decades parathyroid scintigraphy (PS), is applied in almost all patients with pPHT before surgery and specifically before minimally invasive parathyroidectomy. The aim of this study was to find the best cut-off levels of total plasma calcium and intact PTH (iPTH) that correlate with positive technetium-99m-methoxy isobutyl isonitrile ((99m)Tc-MIBI) PS and with positive subtraction PS (SPS) in patients with pHPT and thus the positive diagnostic value of these PS...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28314925/evaluation-of-left-ventricular-functions-in-patients-with-primary-hyperparathyroidism-is-there-any-effect-of-parathyroidectomy
#4
Alper Kepez, Mehmet Yasar, Murat Sunbul, Cigdem Ileri, Oguzhan Deyneli, Bulent Mutlu, Osman Yesildag, Yelda Basaran
PURPOSE: Our aim was to evaluate left ventricular (LV) systolic and diastolic functions of primary hyperparathyroidism (pHPT) patients with detailed echocardiographic analysis and investigate the effect of parathyroidectomy on echocardiographic parameters. METHODS: A total of 22 eligible consecutive patients with pHPT who underwent parathyroidectomy operation were recruited to the study. Another 22 subjects with similar age, gender and frequency of cardiovascular risk factors compared to patients were used as a control group...
March 17, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28302014/role-of-hepcidin-25-in-chronic-kidney-disease-anemia-and-beyond
#5
Norishi Ueda, Kazuya Takasawa
Iron is an essential element for all living organisms, but produces toxic oxidants. Thus, iron homeostasis is tightly regulated in mammals. Hepcidin-25 (hepcidin) has emerged as a molecule that regulates iron metabolism. Binding of hepcidin to its receptor, ferroportin, inhibits intestinal iron absorption and iron efflux from hepatocytes and macrophages. Decreased hepcidin enhances iron absorption and efflux. Hepcidin could be predictive of iron status and the response to iron supplementation or erythropoietin-stimulating agents...
March 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28298867/stones-bones-groans-thrones-and-psychiatric-overtones-systemic-associations-of-sclerochoroidal-calcification
#6
Jordan A Sugarman, Alexzandra M Douglass, Emil Anthony T Say, Carol L Shields
Sclerochoroidal calcification (SCC) is a frequent masquerader of choroidal melanoma with important systemic associations such as hyperparathyroidism and parathyroid adenoma. Herein, we describe a case of a 67-year-old male who presented with an amelanotic choroidal lesion in the right eye (OD) and a history of kidney stones. Ultrasonography showed the lesion to be flat and calcified OD. Incidentally, a subclinical calcified plaque was also found in the fellow eye. Optical coherence tomography showed an elevated suprachoroidal mass in a table mountain configuration OD and flat configuration left eye, consistent with type 4 and type 1 SCC...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28298326/let-7-and-microrna-148-regulate-parathyroid-hormone-levels-in-secondary-hyperparathyroidism
#7
Vitali Shilo, Irit Mor-Yosef Levi, Roy Abel, Aleksandra Mihailović, Gilad Wasserman, Tally Naveh-Many, Iddo Z Ben-Dov
Secondary hyperparathyroidism commonly complicates CKD and associates with morbidity and mortality. We profiled microRNA (miRNA) in parathyroid glands from experimental hyperparathyroidism models and patients receiving dialysis and studied the function of specific miRNAs. miRNA deep-sequencing showed that human and rodent parathyroids share similar profiles. Parathyroids from uremic and normal rats segregated on the basis of their miRNA expression profiles, and a similar finding was observed in humans. We identified parathyroid miRNAs that were dysregulated in experimental hyperparathyroidism, including miR-29, miR-21, miR-148, miR-30, and miR-141 (upregulated); and miR-10, miR-125, and miR-25 (downregulated)...
March 15, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28294593/effect-of-vitamin-d-replacement-in-primary-hyperparathyroidism-with-concurrent-vitamin-d-deficiency-a-systematic-review-and-meta-analysis
#8
Huai Heng Loh, Lee Ling Lim, Anne Yee, Huai Seng Loh, Shireene R Vethakkan
INTRODUCTION: We conducted a meta-analysis to assess the effects of vitamin D replacement on biochemical and skeletal parameters in subjects with mild primary hyperparathyroidism (PHPT) and coexistent vitamin D deficiency. EVIDENCE ACQUISITION: A systematic search of all English-language medical literature published from 1980 till May 2016 using Pubmed, Embase and Ovid was performed. Nine observational studies were evaluated after fulfilling the inclusion and exclusion criteria...
March 14, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28289433/the-serum-level-of-25-hydroxyvitamin-d-for-maximal-suppression-of-parathyroid-hormone-in-children-the-relationship-between-25-hydroxyvitamin-d-and-parathyroid-hormone
#9
Jung In Kang, Yoon Suk Lee, Ye Jin Han, Kyoung Ae Kong, Hae Soon Kim
PURPOSE: Serum level of 25-hydroxyvitamin D (25-OHD) is considered as the most appropriate marker of vitamin D status. However, only a few studies have investigated the relationship between 25-OHD and parathyroid hormone (PTH) in children. To this end, this study was aimed at evaluating the lowest 25-OHD level that suppresses the production of parathyroid hormone in children. METHODS: A retrospective record review was performed for children aged 0.2 to 18 years (n=193; 106 boys and 87 girls) who underwent simultaneous measurements of serum 25-OHD and PTH levels between January 2010 and June 2014...
February 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28288139/mice-deleted-for-cell-division-cycle-73-gene-develop-parathyroid-and-uterine-tumours-model-for-the-hyperparathyroidism-jaw-tumour-syndrome
#10
G V Walls, M Stevenson, K E Lines, P J Newey, A A C Reed, M R Bowl, J Jeyabalan, B Harding, K J Bradley, S Manek, J Chen, P Wang, B O Williams, B T Teh, R V Thakker
The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malignant neoplasms. HPT-JT is caused by mutations of the cell division cycle 73 (CDC73) gene, located on chromosome 1q31.2 and encodes a 531 amino acid protein, parafibromin. To facilitate in vivo studies of Cdc73 in tumourigenesis we generated conventional (Cdc73(+/-)) and conditional parathyroid-specific (Cdc73(+/L)/PTH-Cre and Cdc73(L/L)/PTH-Cre) mouse models...
March 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28286773/the-strategy-to-prevent-and-regress-the-vascular-calcification-in-dialysis-patients
#11
REVIEW
Nai-Ching Chen, Chih-Yang Hsu, Chien-Liang Chen
The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia. The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure. In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28280638/a-giant-cell-lesion-with-cellular-cannibalism-in-the-mandible-case-report-and-review-of-brown-tumors-in-hyperparathyroidism
#12
Lorenzo Azzi, Laura Cimetti, Matteo Annoni, Diego Anselmi, Lucia Tettamanti, Angelo Tagliabue
A small radiolucent area in the mandible was discovered in a 58-year-old woman with no oral complaints. The patient's history included only hypertension. The lesion was considered as an inflammatory cyst and was enucleated. Three months later, a CT revealed the presence of a cyst-like lesion in the mandible with thin expanded buccal cortical plate, localized erosion, and a polylobate appearance on the lingual aspect of the cortical plate. The histological diagnosis of the lesion was central giant-cell granuloma (CGCG)...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28277829/etelcalcetide-for-the-treatment-of-secondary-hyperparathyroidism
#13
Naoto Hamano, Hirotaka Komaba, Masafumi Fukagawa
Calcium sensing receptor is an important target for the treatment of secondary hyperparathyroidism (SHPT). Etelcalcetide hydrochloride is a novel peptide calcimimetic agent that has a similar mechanism of action as cinacalcet hydrochloride. Clinical trials of etelcalcetide have been performed in the US, Europe, and Japan, and these trials demonstrated the safety and efficacy of etelcalcetide in dialysis patients. Etelcalcetide has recently been approved in Europe, the US and Japan. Areas covered: We review the development, pharmacokinetics, and clinical efficacy and safety of etelcalcetide for the treatment of SHPT in hemodialysis patients...
March 4, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28277104/self-diagnosis-of-hyperparathyroidism-during-pregnancy-resulting-in-parathyroidectomy-and-uncomplicated-delivery
#14
Aleksandra Medza, Lukasz Obolonczyk, Anna Lewalska, Tomasz Buss, Rafal Peksa, Malgorzata Siekierska-Hellmann, Monika Berendt-Obolonczyk, Piotr Wisniewski, Krzysztof Sworczak
Primary hyperparathyroidism is a condition with hypercalcemia and elevated parathyroid hormone (PTH). Typically, treating patients with such disease does not pose a problem for doctors, unless the patient is pregnant. Firstly, pregnancy may mask signs of hypercalcemia. Secondly, treatment should be applied with special care for immature fetus. If undiagnosed and untreated, it is life-threatening for the mother and the baby. The main cause of primary hyperparathyroidism is parathyroid adenoma, which should be removed surgically in second trimester...
March 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28273687/long-term-hypovitaminosis-d-and-secondary-hyperparathyroidism-outcomes-of-the-roux-en-y-gastric-bypass-a-systematic-review
#15
REVIEW
N J Switzer, G Marcil, S Prasad, E Debru, N Church, P Mitchell, E O Billington, R S Gill
INTRODUCTION: Pre-operative Vitamin D deficiency is markedly prevalent in prospective bariatric surgery patients. While bariatric surgery leads to significant weight loss, it can exacerbate or prolong Vitamin D deficiency. We systematically reviewed the literature to assess whether secondary hyperparathyroidism is maintained in the medium to long term in patients following the Roux-en-Y gastric bypass. METHODS: A comprehensive literature search was conducted through Medline, Embase, Scopus, Web of Science, Dare, Cochrane library and HTA database...
March 8, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28272298/serum-parathyroid-hormone-responses-to-vitamin-d-supplementation-in-overweight-obese-adults-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#16
REVIEW
Ashley Lotito, Masaru Teramoto, May Cheung, Kendra Becker, Deeptha Sukumar
Obesity is often associated with vitamin D deficiency and secondary hyperparathyroidism. Vitamin D supplementation typically leads to the reductions in serum parathyroid hormone (PTH) levels, as shown in normal weight individuals. Meanwhile, the dose of vitamin D supplementation for the suppression of PTH may differ in overweight and obese adults. We conducted a systematic review and meta-analysis of randomized controlled trials to determine the dose of vitamin D supplementation required to suppress PTH levels in overweight/obese individuals...
March 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28262264/the-incidence-of-new-onset-diabetes-after-transplantation-and-related-factors-single-center-experience
#17
Ayse Sinangil, Vedat Celik, Soykan Barlas, Yener Koc, Taner Basturk, Tamer Sakaci, Emin Baris Akin, Tevfik Ecder
AIM: New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication and is considered a risk factor for patients undergoing renal transplant. The aim of this study was to evaluate the incidence and developing duration of new-onset diabetes after transplant (NODAT) and influencing factors. METHODS: All patients' data was investigated retrospectively. Diabetics, follow-up period<6 months, age<18years were excluded. Demographic, clinical and laboratory data was recorded...
March 2, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28258382/-is-autotransplantation-with-parathyroidectomy-for-secondary-hyperparathyroidism-outdated
#18
H Dralle
No abstract text is available yet for this article.
March 3, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28253186/brown-tumor-clinical-findings-of-secondary-hyperparathyroidism-in-patients-with-renal-osteodystrophy
#19
Mairaira Teles Leão E Silva, Juliana Silva Barros Cedraz, Caetano Guilherme Carvalho Pontes, Cleverson Luciano Trento, Bernardo Ferreira Brasileiro, Marta Rabello Piva, Fabiano Alvim Pereira
A brown tumor, or osteoclastoma, is a nonneoplastic bony lesion associated with hyperparathyroidism and directly related to increased levels of parathyroid hormone. These tumors result from excessive osteoclastic activity. This article presents 3 cases of brown tumor localized in facial bones. The lesions were the result of secondary hyperparathyroidism associated with chronic renal failure. The patients were two 42-year-old men and a 39-year-old woman. All patients had been treated systemically by hemodialysis for more than 10 years...
March 2017: General Dentistry
https://www.readbyqxmd.com/read/28251020/regional-clinical-and-biochemical-differences-among-patients-with-primary-hyperparathyroidism
#20
Özer Makay, Beyza Özçınar, Turgay Şimşek, Cumhur Arıcı, Bülent Güngör, Serdar Özbaş, Tamer Akça, Ali Uğur Emre, Güldeniz Karadeniz Çakmak, Müfide Akçay, Bülent Ünal, Mustafa Girgin, Sadullah Girgin, Semih Görgülü, Atakan Sezer, Adem Karataş, İbrahim Ali Özemir, Nihat Aksakal, Serap Erel, M Ümit Uğurlu, Ali İlker Filiz, Can Atalay, Ali Uzunköy, Uğur Deveci, Çetin Kotan, Gökhan İçöz, Yavuz Kurt, Abut Kebudi, N Zafer Cantürk, Yeşim Erbil, Rumen Pandev, Bahadır M Güllüoğlu
BACKGROUND: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. STUDY DESIGN: Retrospective, clinical-based multi-centric study of 694 patients with pHPT. METHODS: Patients from 23 centers and 8 different geographical regions were included...
January 2017: Balkan Medical Journal
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