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https://www.readbyqxmd.com/read/29456218/renal-anemia-syndromes-in-iraqi-hemodialysis-patients-according-to-iron-status
#1
Ala Ali, Riyadh M Salih
Anemia is common in patients on hemodialysis (HD). Adequate iron stores are essential for achieving the best hemoglobin level through maximum benefit from erythropoiesis-stimulating agents (ESA). Decreased iron stores or decreased availability of iron are the most common reasons for resistance to the effect of these agents. Our objective was to categorize a group of Iraqi HD patients according to absolute or functional iron deficiency anemia (IDA); this study was conducted in the HD unit of the Baghdad Teaching Hospital from October 2012 to January 2013...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455549/multiple-endocrine-neoplasia-2a-men-2a-syndrome
#2
J Breza, J Breza
INTRODUCTION: In the MEN 2A syndrome, which is the most common of the three types of MEN, three endocrine systems are affected simultaneously or subsequently by the development of tumours manifested by medullary thyroid gland carcinoma, pheochromocytoma (often bilateral) and hyperparathyroidism. MATERIAL AND METHODS: 27 patients from 3 families affected by MEN 2A syndrome were examined clinically (by detecting the effects of catecholamine overproduction), biochemically (screening for metanephrine and normetanephrine in the serum), visualization (CT, MRI, MIBG, PET CT) and some of them also genetically (DNA fragment analysis obtained by PCR amplification)...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29453660/verification-of-candidate-microrna-markers-for-parathyroid-carcinoma
#3
Ya Hu, Xiang Zhang, Ming Cui, Zhe Su, Mengyi Wang, Quan Liao, Yupei Zhao
PURPOSE: Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of miRNA markers in a new series of samples to explore their potential significance in PCa diagnosis. METHODS: A total of 58 tissue samples, including 17 PCa lesions and 41 sporadic parathyroid adenomas (PAds), were obtained from 56 primary hyperparathyroidism (pHPT) patients...
February 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29449603/cinacalcet-versus-placebo-for-secondary-hyperparathyroidism-in-chronic-kidney-disease-patients-a-meta-analysis-of-randomized-controlled-trials-and-trial-sequential-analysis
#4
Guoqi Wang, Hongyan Liu, Chengzhi Wang, Xiaojian Ji, Weijun Gu, Yiming Mu
To assess the efficacy and safety of cinacalcet on secondary hyperparathyroidism in patients with chronic kidney disease, Pubmed, Embase, and the Cochrane Central Register of Controlled Trials were searched until March 2016. Trial sequential analysis (TSA) was conducted to control the risks of type I and II errors and calculate required information size (RIS). A total of 25 articles with 8481 participants were included. Compared with controls, cinacalcet administration did not reduce all-cause mortality (RR = 0...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29446693/hyperparathyroidism-mimicking-metastatic-bone-disease-a-case-report-and-review-of-literature
#5
Monica Gupta, Lalita Singhal, Akshay Kumar
Multiple osteolytic lesions are usually associated with metastatic involvement of the bone; however, metabolic bone diseases should also be included in the differential diagnosis. In this study, we describe a case of primary hyperparathyroidism (PHPT) with multiple osteolytic lesions that was diagnosed initially as having metastatic bone involvement. The laboratory results showed hypercalcemia and raised alkaline phosphatase along with fibrosis in the bone marrow biopsy with no increase in tumor markers and normal serum protein electrophoresis...
February 15, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29446565/targeted-surgical-parathyroidectomy-in-end-stage-renal-disease-patients-and-long-term-metabolic-control-a-single-center-experience-in-the-current-era
#6
Tibor Fülöp, Christian A Koch, Abdeen R Farah Musa, Christopher M Clark, Kamel A Gharaibeh, Zsolt Lengvársky, Mehrdad Hamrahian, Karen T Pitman, Mehul P Dixit
BACKGROUND: The long-term results of surgical parathyroidectomy (PTX) in end-stage renal disease (ESRD) patients are less well known in the modern era of newer activated vitamin-D analogs, calcimimetics and intraoperative monitoring of parathyroid hormone (PTH). METHODS: We performed a retrospective chart review of all ESRD patients undergoing PTX at the University of Mississippi Medical Center between January 2005 and August 2011, with follow-up data as available up to 4 years...
February 15, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29442350/occult-phosphaturic-mesenchymal-tumor-of-femur-cortex-causing-oncogenic-osteomalacia-diagnostic-challenges-and-clinical-outcomes
#7
Deep Dutta, Raghuvansh Kumar Pandey, Rakhee Gogoi, Nagender Solanki, Renu Madan, Anupam Mondal, Shruti Dogra, Pradeep Thapa
BACKGROUND: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Investigations were significant for severe hypophosphatemia, severe phosphaturia, normal serum calcium, reduced 1,25-dihydroxy vitamin-D, elevated ALP, elevated intact parathyroid hormone (iPTH), and pseudo-fractures involving pelvis and bilateral femur...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442060/thyroid-hemiagenesis-associated-with-multinodular-goiter-and-hashimoto-s-thyroiditis
#8
Daniela Bosco, A Cammarata, R Cannarella, R Latino, R Lanteri, A Di Cataldo, A Calogero
Thyroid hemiagenesis is a rare congenital abnormality in which one of the thyroid lobes is not developed. It can be associated with various thyroid diseases, such as Grave's disease, nodular goiter and thyroid neoplasm, rarely with hyperparathyroidism. We report a case of a 50-year old woman with left thyroid lobe agenesis diagnosed by ultrasonography and scintigraphy. Right thyroidectomy was performed and the histopathological examination showed diffuse hyperplasia, multinodular goiter and Hashimoto's thyroiditis...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29441335/clinical-usefulness-of-intraoperative-parathyroid-hormone-monitoring-for-primary-hyperparathyroidism
#9
Se Hyun Paek, Su-Jin Kim, June Young Choi, Kyu Eun Lee
Purpose: The availability of intraoperative parathyroid hormone (IOPTH) monitoring allows successful focused parathyroidectomy for primary hyperparathyroidism (pHPT). The objective of this study was to report our initial experience in IOPTH monitoring during parathyroid surgery for primary hyperparathyroidsim. Methods: Between May 2011 and February 2013, 37 patients underwent focused parathyroidectomy due to pHPT. IOPTH monitoring based on Miami criteria was used to confirm complete excision of hyperfunctioning parathyroid gland during surgery...
February 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29440923/managing-hyperparathyroidism-in-hemodialysis-role-of-etelcalcetide
#10
REVIEW
Keith E Eidman, James B Wetmore
Secondary hyperparathyroidism (SHPT) is common in patients receiving maintenance hemodialysis and is associated with adverse outcomes. Currently, SHPT is managed by reducing circulating levels of phosphate with oral binders and parathyroid hormone (PTH) with vitamin D analogs and/or the calcimimetic cinacalcet. Etelcalcetide, a novel calcimimetic administered intravenously (IV) at the end of a hemodialysis treatment session, effectively reduces PTH in clinical trials when given thrice weekly. Additional clinical effects include reductions in circulating levels of phosphate and FGF-23 and an improved profile of markers of bone turnover...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29439698/a-retrospective-analysis-of-bone-mineral-status-in-patients-requiring-spinal-surgery
#11
Tobias Schmidt, Katharina Ebert, Tim Rolvien, Nicola Oehler, Jens Lohmann, Luca Papavero, Ralph Kothe, Michael Amling, Florian Barvencik, Haider Mussawy
BACKGROUND: Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders. METHODS: We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin...
February 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29439405/cholecalciferol-additively-reduces-serum-parathyroid-hormone-levels-in-severe-secondary-hyperparathyroidism-treated-with-calcitriol-and-cinacalcet-among-hemodialysis-patients
#12
Cai-Mei Zheng, Chia-Chao Wu, Chi-Feng Hung, Min-Tser Liao, Jia-Fwu Shyu, Yung-Ho Hsu, Chien-Lin Lu, Yuan-Hung Wang, Jing-Quan Zheng, Tian-Jong Chang, Yuh-Feng Lin, Kuo-Cheng Lu
We evaluated the improvement of intact parathyroid hormone (iPTH) levels and bone parameters by supplementing nutritional vitamin D (cholecalciferol) to combined calcimimetic (cinacalcet) and active vitamin D analog (calcitriol) among severe secondary hyperparathyroidism (SHPT) hemodialysis (HD) patients. A randomized, controlled open-label study was undertaken in 60 HD patients with serum iPTH > 1000 pg/mL or persistently high iPTH ≥ 600 pg/mL even after >3 months of calcitriol (3 μg/week). The study group received oral cholecalciferol (5000 IU/ day) and the control group received a placebo...
February 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29437827/normocalcaemic-primary-hyperparathyroidism-a-pragmatic-approach
#13
REVIEW
Feaz Babwah, Harit N Buch
It is well recognised that over the past three to four decades the incidence of asymptomatic primary hyperparathyroidism has increased significantly. However, more recently this pattern has further evolved into a presentation with normocalcaemia and raised parathyroid hormone (PTH) level without the presence of a recognised stimulus for its rise, in the form of vitamin D deficiency or renal impairment. A diagnostic label of normocalcaemic hyperparathyroidism (NPHPT) has been given to this phenotype and in most such individuals, the initial PTH measurement is driven by the presence of metabolic bone disease...
February 3, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29436275/predictors-of-readmission-and-reoperation-in-patients-undergoing-parathyroidectomy-for-primary-hyperparathyroidism
#14
Ansley M Roche, Jason A Brant, And Raymond L Chai
Objective Identify risk factors for 30-day reoperation and readmission after parathyroidectomy for primary hyperparathyroidism. Study Design Retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database from 2012 through 2014. Subjects and Methods Patients undergoing parathyroidectomy and parathyroid reexploration for primary hyperparathyroidism. Univariate and multivariate analyses were conducted to determine risk factors for reoperation and readmission...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29430234/excision-of-an-elusive-tiny-ectopic-parathyroid-adenoma
#15
Andre Navarro, Josanne Vassallo, Joseph Galea
An elderly lady was diagnosed with primary hyperparathyroidism after being admitted to hospital with pyelonephritis and constipation. A sestamibi parathyroid scan demonstrated increased uptake in the upper mediastinum, suggesting an ectopic mediastinal parathyroid adenoma. The 4-mm adenoma was successfully removed through a mini-sternotomy incision using a gamma probe to identify the gland from the surrounding tissue. The patient made an uneventful recovery.
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29429952/primary-hyperparathyroidism-diagnosed-and-treated-surgically-during-pregnancy
#16
Asma Rostom, María de la Calle, José Luis Bartha, Alejandro Castro, Beatriz Lecumberri
No abstract text is available yet for this article.
February 8, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29429003/parathyroid-autotransplantation-in-thyroid-surgery
#17
REVIEW
Antonio Sitges-Serra, Leyre Lorente-Poch, Juan Sancho
BACKGROUND: Careful parathyroid gland dissection and in situ preservation was the time-honored approach to prevent parathyroid failure after total thyroidectomy. The relative success of parathyroid autotransplantation of hyperplastic parathyroid tissue in patients with renal or hereditary hyperparathyroidism did popularize the use of normal parathyroid tissue autografts during thyroidectomy to prevent permanent hypoparathyroidism. Proof of autograft function in this setting, however, is controversial...
February 10, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29423207/old-and-new-calcimimetics-for-treatment-of-secondary-hyperparathyroidism-impact-on-biochemical-and-relevant-clinical-outcomes
#18
Luciano Pereira, Catarina Meng, Daniela Marques, João M Frazão
Secondary hyperparathyroidism (SHPT) is associated with increased bone turnover, risk of fractures, vascular calcifications, and cardiovascular and all-cause mortality. The classical treatment for SHPT includes active vitamin D compounds and phosphate binders. However, achieving the optimal laboratory targets is often difficult because vitamin D sterols suppress parathyroid hormone (PTH) secretion, while also promoting calcium and phosphate intestinal absorption. Calcimimetics increase the sensitivity of the calcium-sensing receptor, so that even with lower levels of extracellular calcium a signal can still exist, leading to a decrease of the set-point for systemic calcium homeostasis...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29423205/ckd-mbd-kdigo-guidelines-how-difficult-is-reaching-the-target
#19
Mario Cozzolino
Patients with chronic kidney disease (CKD) are affected by mineral and bone disorder (MBD), resulting in abnormalities in serum calcium (Ca), phosphorous (P) and parathyroid hormone (PTH). Changes in mineral metabolism have also been associated with higher rates of both all-cause and cardiovascular-related mortality. The majority of haemodialysis patients are also deficient in the endogenous hormone 1,25-dihydroxyvitamin D (calcitriol), often contributing to increased secondary hyperparathyroidism (SHPT) and consequently to abnormal levels of Ca, P and PTH...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29423140/maximum-cosmesis-for-patients-with-primary-hyperparathyroidism-a-case-for-larger-incisions
#20
Yazan N AlJamal, Raaj K Ruparel, Steven R Jacobson, David R Farley
While minimally invasive parathyroidectomy is an advantage to many properly selected patients, longer incisions and even wide skin resection may be optimal in a select few. We present an 80-year-old woman with primary hyperparathyroidism and bothersome excess neck skin and subcutaneous fat. The parathyroid adenoma was easily excised through a vertically-oriented cervical excision that removed an ellipse of fat and skin. Midline wound closure with a small Z-plasty to avoid wound tethering facilitated a cosmetic closure well within the surgical capabilities of endocrine surgeons...
October 2017: Journal of Surgical Case Reports
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