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Hyperparathyroid

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https://www.readbyqxmd.com/read/29229131/racial-disparities-in-the-cost-of-surgical-care-for-parathyroidectomy
#1
Samuel Jang, Meagan Mandabach, Zviadi Aburjania, Courtney J Balentine, Herbert Chen
BACKGROUND: Parathyroidectomy is the only curative therapy for hyperparathyroidism, but its cost and variation in use among different racial and ethnic groups are largely unexamined. The purpose of this study was to examine the association between race and ethnicity and the total hospital cost of parathyroidectomy. METHODS: This retrospective study included 899 consecutive complete parathyroidectomies in our institution between September 2011 and July 2016. Total length of stay and cost were primary outcomes...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29227640/raman-spectroscopy-applied-to-parathyroid-tissues-a-new-diagnostic-tool-to-discriminate-normal-tissue-from-adenoma
#2
Andrea Palermo, Marco Fosca, Gaia Tabacco, Federico Marini, Valerio Graziani, Maria Carla Santarsia, Filippo Longo, Angelo Lauria, Roberto Cesareo, Isabella Giovannoni, Chiara Taffon, Massimiliano Rocchia, Silvia Manfrini, Pierfilippo Crucitti, Paolo Pozzilli, Anna Crescenzi, Julietta V Rau
Primary hyperparathyroidism is an endocrine disorder characterized by autonomous production of parathyroid hormone. Patients with the symptomatic disease should be referred for parathyroidectomy. However, the distinction between the pathological condition and the benign one is very challenging in the surgical setting; therefore, accurate recognition is important to ensure success during minimally invasive surgery. At present, all intraoperative techniques significantly increase surgical time and, consequently, cost...
December 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29225978/coexistence-of-gh-producing-pituitary-macroadenoma-and-meningioma-in-a-patient-with-multiple-endocrine-neoplasia-type-1-with-hyperglycemia-and-ketosis-as-first-clinical-sign
#3
A Herrero-Ruiz, H S Villanueva-Alvarado, J J Corrales-Hernández, C Higueruela-Mínguez, J Feito-Pérez, J M Recio-Cordova
We present the clinical case of a patient who was admitted with an onset of diabetes mellitus (DM) with associated ketosis and whose clinical, hormonal, and radiological evolution revealed the presence of primary hyperparathyroidism, pancreatic neuroendocrine tumor, and GH-producing pituitary macroadenoma in the context of multiple endocrine neoplasia type 1 (MEN1). DM is relatively common in cases of acromegaly, but it is not generally associated with ketosis. Simultaneously, the patient presented a meningioma, which is associated with pituitary macroadenoma only in extremely rare cases...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29225260/a-case-of-hyperparathyroidism-jaw-tumor-syndrome-confirmed-by-preoperative-genetic-testing
#4
Kenji Koikawa, Yosuke Okada, Hiroko Mori, Mayuko Kawaguchi, Shinya Uchino, Yoshiya Tanaka
We herein report the case of a young woman who was diagnosed with primary hyperparathyroidism and in whom genetic testing confirmed a diagnosis of hyperparathyroidism-jaw tumor syndrome. Familial hyperparathyroidism was suspected based on the patient's young age at the onset of the disease.Thus, genetic testing was performed.It showed a germline mutation in the HRPT2/CDC73 gene and confirmed the diagnosis of hyperparathyroidism-jaw tumor syndrome. Total parathyroidectomy was performed to prevent recurrence...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29225207/parathyroid-carcinoma-occurred-in-two-glands-in-multiple-endocrine-neoplasia-1-a-report-on-a-rare-case
#5
Yoko Omi, Kiyomi Horiuchi, Kento Haniu, Momoko Tokura, Erin Nagai, Osamu Isozaki, Yoji Nagashima, Takahiro Okamoto
Primary hyperparathyroidism is the most common hormonal manifestation associated with multiple endocrine neoplasia 1 (MEN1). It is generally caused by parathyroid hyperplasia, and parathyroid carcinoma is rare. Here, we report a case of MEN1 with parathyroid carcinoma in two parathyroid glands causing primary hyperparathyroidism. A 40-year-old man with primary hyperparathyroidism due to MEN1 underwent a total parathyroidectomy. His corrected calcium and intact PTH (i-PTH) serum levels were 10.8 mg/dL and 203 pg/mL, respectively...
December 8, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29221681/hypercalcemic-crisis-and-primary-hyperparathyroidism-cause-of-an-unusual-electrical-storm
#6
Tatiana Guimarães, Miguel Nobre Menezes, Diogo Cruz, Sónia do Vale, Armando Bordalo, Arminda Veiga, Fausto J Pinto, Dulce Brito
Hypercalcemia is a known cause of heart rhythm disorders, however its association with ventricular arrhythmias is rare. The authors present a case of a fifty-three years old male patient with a ischemic and ethanolic dilated cardiomyopathy, and severely reduced ejection fraction, carrier of cardiac resynchronization therapy (CRT) with cardioverter defibrillator (ICD), admitted in the emergency department with an electrical storm, with multiple appropriated ICD shocks, refractory to antiarrhythmic therapy. In the etiological investigation was documented severe hypercalcemia secondary to primary hyperparathyroidism undiagnosed until then...
December 5, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29221466/unusual-pathological-fracture-of-the-clavicle-revealing-primary-hyperparathyroidism-a-case-report
#7
Yassir Benameur, Hasnae Guerrouj, Imad Ghfir, Nouzha Ben Rais Aouad
BACKGROUND: Primary hyperparathyroidism revealed by a pathological fracture is very uncommon; in the majority of cases the discovery of lytic bone lesions on imaging examinations evokes in the clinician first a neoplastic etiology and a metabolic origin is often omitted. This case report adds to the existing literature as it describes an unusual presentation of primary hyperparathyroidism. CASE PRESENTATION: We report a case of a 50-year-old Moroccan man, without any known tumor, who presented a fracture of his left clavicle with multiple osteolytic lesions on computed tomography suggesting bone metastases...
December 9, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29217931/hyper-parathyroidisim-jaw-tumor-syndrome-a-rare-condition-of-incongruous-features
#8
Manchil P Redwin Dhas, Kannan S Karthiga, Joy E Tatu, Sherubin J Eugenia
Background: Hyperparathyroidism-Jaw Tumor (HPT-JT) syndrome is a rare genetic disorder bearing both a germline and a somatic CDC73 mutation (formerly known as HRPT2), which has been mapped to chromosome 1q25-q31. The association of jaw ossifying fibroma with primary hyperparathyroidisim (PHPT) is typical of HPT-JT. It may also include cystic and neoplastic renal abnormalities and uterine tumors. Case Details: Here, we report a case of HPT-JT with an initial presentation of declination in reproductive fitness...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29216631/effect-of-cinacalcet-combined-with-calcitriol-on-the-clinical-outcome-and-bone-metabolism-in-patients-on-hemodialysis-with-severe-secondary-hyperparathyroidism
#9
Fang Yuan, Xing Chen, Chang Wang, Zheng Li, Hong Liu
OBJECTIVE: To observe the clinical outcome and the effect of bone metabolism of cinacalcet combined with calcitriol in maintenance hemodialysis (MHD) patients with severe secondary hyperparathyroidism (SHPT). METHODS: Thirty MHD patients with SHPT were enrolled into the study. All patients were given cinacalcet 25-75 mg and 0.5 μg calcitriol daily. Serum Ca, P, intact parathyroid hormone (iPTH), and bone metabolic markers were measured. The clinical symptoms and their changes were investigated...
December 7, 2017: Blood Purification
https://www.readbyqxmd.com/read/29212579/time-course-of-vitamin-d-depletion-and-repletion-in-reproductive-age-female-c57bl-6-mice
#10
Anthony M Belenchia, Sarah A Johnson, Alyssa C Kieschnick, Cheryl S Rosenfeld, Catherine A Peterson
The use of animal models in vitamin D deficiency (VDD) research, particularly in regard to maternal deficits, has increased dramatically, yet these studies may be confounded due to ill-conceived experimental timelines. We conducted 2 experiments to (1) characterize the time course of VDD induction and repletion and (2) explore the long-term consequences of VDD on calcium homeostasis and body composition in reproductive-age female mice. Eight-week-old female C57BL/6 mice were randomized to receive either a vitamin D sufficient (VDS) or VDD diet; serum was collected weekly...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29209851/elevated-parathyroid-hormone-levels-after-successful-parathyroidectomy-for-primary-hyperparathyroidism-a-clinical-review
#11
REVIEW
Roberto de la Plaza Llamas, José Manuel Ramia Ángel, Vladimir Arteaga Peralta, Cristina García Amador, Aylhín Joana López Marcano, Aníbal Armando Medina Velasco, Begoña González Sierra, Alba Manuel Vázquez, Raquel Aránzazu Latorre Fragua
INTRODUCTION: Surgery for primary hyperparathyroidism (PHPT) is traditionally deemed to be successful if serum calcium levels return to normal 6 months after parathyroidectomy. Regular monitoring of serum calcium and parathyroid hormone (PTH) in the follow-up of patients after parathyroidectomy for PHPT has drawn attention to the presence of a normocalcemic group of patients with elevated PTH (NCePTH) during the post-operative period. The etiological factors and mechanisms underlying this condition, its consequences, and the possibility of treatment are the object of this study...
December 5, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29207788/hyperparathyroidism-during-pregnancy-a-diagnostic-and-therapeutic-challenge
#12
Richa Sharma, Bhanupriya, Vishnu Bhartiya, Kiran Guleria, Amita Suneja
Primary Hyperparathyroidism (PHP) is a rare event in pregnancy; Maternal complications in PHP patients can be as high as 67%. It can be overlooked easily because of many similar complaints shared by hyperparathyroidism and pregnancy such as nausea and vomiting, gastritis, bone aches, easy fatigability. Hypercalcemic crisis can develop resulting in coma and death. Neonatal effects are tetany and death in about 80% of cases. We report a case, of an antenatal woman at 30 weeks gestation with complains of painful swelling in left lower jaw and below right knee, pain over right hip joint and frequent episodes of gastritis...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205012/evaluation-of-the-different-surgical-parathyroidectomieson-secondary-hyperparathyroidism-in-uremia-patients
#13
Litong Zhu, Fei Xiong, Tongxia Cui
No abstract text is available yet for this article.
December 4, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29204278/cured-primary-hyperparathyroidism-after-fine-needle-aspiration-biopsy-induced-parathyroid-disappearance
#14
Elda Kara, Elisa Della Valle, Sara De Vincentis, Vincenzo Rochira, Bruno Madeo
Spontaneous or fine-needle aspiration (FNAB)-induced remission of primary hyperparathyroidism (PHPT) may occur, especially for cystic lesions. However, the disease generally relapses over a short time period. We present a case of PHPT due to an enlarged hyperfunctioning parathyroid that underwent long-term (almost 9 years) clinical and ultrasonographic remission after the disappearance of the lesion following ultrasound (US)-assisted FNAB. A 67-year-old woman with PHPT underwent biochemical and US examinations that confirmed the diagnosis and showed a lesion suggestive for parathyroid adenoma or hyperplasia...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29198075/characteristics-management-and-outcome-of-primary-hyperparathyroidism-at-a-single-clinical-center-from-2005-to-2016
#15
B Sun, B Guo, B Wu, J Kang, X Deng, Z Zhang, Y Fan
This study presents the clinical and biochemical profiles of patients with PHPT between 2005 and 2016 at our center. Most PHPT patients in China show symptomatic features. The number of symptomatic and asymptomatic patients increased during that time, and the number of individuals with parathyroid carcinoma is now increasing. INTRODUCTION: Over the last decade, the prevalence of primary hyperparathyroidism (PHPT) has increased sharply, and the number of individuals with parathyroid cancer is still trending upward...
December 3, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29196929/factors-associated-with-calcium-requirements-after-parathyroidectomy-in-chronic-kidney-disease-patients
#16
Yue Ding, Hongying Wang, Qiang Zou, Yiting Jin, Zijing Zhang, Junwen Huang
BACKGROUND: Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD). Parathyroidectomy (PTX) for these patients continues to be a valuable option in the era of calcimimetics. Postoperative hypocalcemia is common after surgery. The aim of this study was to identify clinical factors to define postoperative calcium requirements. METHODS: From February 2013 to May 2017, 68 patients with chronic kidney disease 5 (CKD5) who underwent PTX were reviewed...
December 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29193813/a-case-report-of-brown-tumor-in-a-patient-with-chronic-renal-failure-and-renal-cell-carcinoma
#17
Yong-Jun Liu, Elizabeth E Frauenhoffer, Eric Walker, Nicole C Williams
We report a case of a 72 year old male with hyperparathyroidism secondary to end stage diabetic renal disease and coexisting bilateral chromophobe renal cell carcinomas. The patient presented with back and groin pain, right pelvic hemorrhage, and multiple lytic bone lesions concerning for metastatic renal cell carcinoma. Fine needle aspiration cytology demonstrated benign appearing osteoclasts and spindled cells. A concurrent core biopsy showed foci of spindled cell proliferation populated by osteoclast-like giant cells with stromal hemorrhage without evidence of metastatic carcinoma...
November 29, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29193308/the-influence-of-chronic-kidney-disease-on-the-structural-and-mechanical-properties-of-canine-bone
#18
A Shipov, R Shahar, N Sugar, G Segev
BACKGROUND: Chronic kidney disease (CKD) is common in companion animals. Secondary hyperparathyroidism is an inevitable consequence of the disease and may have deleterious effect on the bone; however, the information regarding CKD-associated bone abnormalities in companion animals is scarce. HYPOTHESIS/OBJECTIVES: Dogs with CKD have decreased bone quality compared to dogs without CKD. ANIMALS: Nine dogs diagnosed with naturally occurring CKD for at least 6 months and 9 age-matched controls...
November 30, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29192571/-a-man-with-dyspnoea-after-a-kidney-transplant
#19
L C Vermeer, M Veltkamp, A B M Geers
We present a 62-year-old man with a kidney transplant in the past. Because of progressive dyspnoea a CT-scan was made, which showed ground glass in the upper fields with calcifications. He was diagnosed with metastatic pulmonary calcification, which is mostly seen in patient with renal failure and secondary hyperparathyroidism.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29192005/successful-reversal-of-furosemide-induced-secondary-hyperparathyroidism-with-cinacalcet
#20
Tarak Srivastava, Shahryar Jafri, William E Truog, Judith Sebestyen VanSickle, Winston M Manimtim, Uri S Alon
Secondary hyperparathyroidism (SHPT) is a rare complication of furosemide therapy that can occur in patients treated with the loop diuretic for a long period of time. We report a 6-month-old 28-weeks premature infant treated chronically with furosemide for his bronchopulmonary dysplasia, who developed hypocalcemia and severe SHPT, adversely affecting his bones. Discontinuation of the loop diuretic and the addition of supplemental calcium and calcitriol only partially reversed the SHPT, bringing serum parathyroid hormone level down from 553 to 238 pg/mL...
December 2017: Pediatrics
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