keyword
MENU ▼
Read by QxMD icon Read
search

epidemic outbreak

keyword
https://www.readbyqxmd.com/read/28231269/a-mouse-model-of-paralytic-myelitis-caused-by-enterovirus-d68
#1
Alison M Hixon, Guixia Yu, J Smith Leser, Shigeo Yagi, Penny Clarke, Charles Y Chiu, Kenneth L Tyler
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory disease. Up to half of the 2014 AFM patients had EV-D68 RNA detected by RT-PCR in their respiratory secretions, although EV-D68 was only detected in cerebrospinal fluid (CSF) from one 2014 AFM patient. Given previously described molecular and epidemiologic associations between EV-D68 and AFM, we sought to develop an animal model by screening seven EV-D68 strains for the ability to induce neurological disease in neonatal mice...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28231235/near-real-time-surveillance-of-u-s-norovirus-outbreaks-by-the-norovirus-sentinel-testing-and-tracking-network-united-states-august-2009-july-2015
#2
Minesh P Shah, Mary E Wikswo, Leslie Barclay, Anita Kambhampati, Kayoko Shioda, Umesh D Parashar, Jan Vinjé, Aron J Hall
Norovirus is the leading cause of endemic and epidemic acute gastroenteritis in the United States (1). New variant strains of norovirus GII.4 emerge every 2-4 years (2-4) and are often associated with increased disease and health care visits (5-7). Since 2009, CDC has obtained epidemiologic data on norovirus outbreaks from state health departments through the National Outbreak Reporting System (NORS) (8) and laboratory data through CaliciNet (9). NORS is a web-based platform for reporting waterborne, foodborne, and enteric disease outbreaks of all etiologies, including norovirus, to CDC...
February 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28230525/inference-and-forecast-of-h7n9-influenza-in-china-2013-to-2015
#3
Ruiyun Li, Yuqi Bai, Alex Heaney, Sasikiran Kandula, Jun Cai, Xuyi Zhao, Bing Xu, Jeffrey Shaman
The recent emergence of A(H7N9) avian influenza poses a significant challenge to public health in China and around the world; however, understanding of the transmission dynamics and progression of influenza A(H7N9) infection in domestic poultry, as well as spillover transmission to humans, remains limited. Here, we develop a mathematical model-Bayesian inference system which combines a simple epidemic model and data assimilation method, and use it in conjunction with data on observed human influenza A(H7N9) cases from 19 February 2013 to 19 September 2015 to estimate key epidemiological parameters and to forecast infection in both poultry and humans...
February 16, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28229043/detection-and-molecular-characterization-of-the-mosquito-borne-filarial-nematode-setaria-tundra-in-danish-roe-deer-capreolus-capreolus
#4
Heidi Larsen Enemark, Antti Oksanen, Mariann Chriél, Jakob le Fèvre Harslund, Ian David Woolsey, Mohammad Nafi Solaiman Al-Sabi
Setaria tundra is a mosquito-borne filarial nematode of cervids in Europe. It has recently been associated with an emerging epidemic disease causing severe morbidity and mortality in reindeer and moose in Finland. Here, we present the first report of S. tundra in six roe deer (Capreolus capreolus) collected between October 2010 and March 2014 in Denmark. The deer originated from various localities across the country: the eastern part of the Jutland peninsular and four locations on the island Zealand. With the exception of one deer, with parasites residing in a transparent cyst just under the liver capsule, worms (ranging from 2 to >20/deer) were found free in the peritoneal cavity...
April 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28228590/a-polymorphism-within-the-internal-fusion-loop-of-the-ebola-virus-glycoprotein-modulates-host-cell-entry
#5
Markus Hoffmann, Lisa Crone, Erik Dietzel, Jennifer Paijo, Mariana González-Hernández, Inga Nehlmeier, Ulrich Kalinke, Stephan Becker, Stefan Pöhlmann
The large scale of the Ebola virus disease (EVD) outbreak in West Africa in 2013-2016 raised the question whether the host cell interactions of the responsible Ebola virus (EBOV) strain differed from those of other ebolaviruses. We previously reported that the glycoprotein (GP) of the virus circulating in West Africa in 2014 (EBOV2014) exhibited reduced ability to mediate entry into two non-human primate (NHP)-derived cell lines relative to the GP of EBOV1976. Here, we investigated the molecular determinants underlying the differential entry efficiency...
February 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28225804/an-outbreak-of-acute-respiratory-disease-caused-by-a-virus-associated-rna-ii-gene-mutation-strain-of-human-adenovirus-7-in-china-2015
#6
Xiaoxia Yang, Qiongshu Wang, Beibei Liang, Fuli Wu, Hao Li, Hongbo Liu, Chunyu Sheng, Qiuxia Ma, Chaojie Yang, Jing Xie, Peng Li, Leili Jia, Ligui Wang, Xinying Du, Shaofu Qiu, Hongbin Song
Human adenovirus 7 (HAdV-7) strains are a major cause of acute respiratory disease (ARD) among adults and children, associated with fatal pneumonia. An ARD outbreak caused by HAdV-7 that involved 739 college students was reported in this article. To better understand the underlying cause of this large-scale epidemic, virus strains were isolated from infected patients and sequence variations of the whole genome sequence were detected. Evolutionary trees and alignment results indicated that the major capsid protein genes hexon and fibre were strongly conserved among serotype 7 strains in China at that time...
2017: PloS One
https://www.readbyqxmd.com/read/28225040/vulnerability-of-the-british-swine-industry-to-classical-swine-fever
#7
Thibaud Porphyre, Carla Correia-Gomes, Margo E Chase-Topping, Kokouvi Gamado, Harriet K Auty, Ian Hutchinson, Aaron Reeves, George J Gunn, Mark E J Woolhouse
Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during the 2000 epidemic of CSF in Great Britain (GB), a spatially explicit, premises-based model was developed to explore the risk of CSF spread in GB. We found that large outbreaks of CSF would be rare and generated from a limited number of areas in GB...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28223458/mutation-of-the-n-terminal-region-of-chikungunya-virus-capsid-protein-implications-for-vaccine-design
#8
Adam Taylor, Xiang Liu, Ali Zaid, Lucas Y H Goh, Jody Hobson-Peters, Roy A Hall, Andres Merits, Suresh Mahalingam
Mosquito-transmitted chikungunya virus (CHIKV) is an arthritogenic alphavirus of the Togaviridae family responsible for frequent outbreaks of arthritic disease in humans. Capsid protein, a structural protein encoded by the CHIKV RNA genome, is able to translocate to the host cell nucleolus. In encephalitic alphaviruses, nuclear translocation induces host cell transcriptional shutoff; however, the role of capsid protein nucleolar localization in arthritogenic alphaviruses remains unclear. Using recombinant enhanced green fluorescent protein (EGFP)-tagged expression constructs and CHIKV infectious clones, we describe a nucleolar localization sequence (NoLS) in the N-terminal region of capsid protein, previously uncharacterized in CHIKV...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28222831/tracking-and-predicting-hand-foot-and-mouth-disease-hfmd-epidemics-in-china-by-baidu-queries
#9
Q Y Xiao, H J Liu, M W Feldman
Hand, foot, and mouth disease (HFMD) is highly prevalent in China, and more efficient methods of epidemic detection and early warning need to be developed to augment traditional surveillance systems. In this paper, a method that uses Baidu search queries to track and predict HFMD epidemics is presented, and the outbreaks of HFMD in China during the 60-month period from January 2011 to December 2015 are predicted. The Pearson correlation coefficient (R) of the predictive model and the mean absolute percentage errors between observed HFMD case counts and the predicted number show that our predictive model gives excellent fit to the data...
February 22, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28222687/a-controlled-survey-of-less-typical-long-term-consequences-after-an-extensive-waterborne-epidemic
#10
Janne Laine, Outi Laine, Jukka Lumio, Jaakko Antonen, Salla Toikkanen, Mikko J Virtanen, Markku Kuusi
BACKGROUND: Extensive backflow of treated wastewater caused household water contamination in a Finnish town in 2007. The drinking water of 9 500 residents became heavily polluted with faecal microbes, resulting in a large gastroenteritis epidemic. Cases of reactive arthritis, milder joint symptoms and prolonged gastrointestinal symptoms were observed after the outbreak. A follow-up survey was performed to study less familiar long-term health consequences within a year from the outbreak...
February 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28222682/a-statistical-method-utilizing-information-of-imported-cases-to-estimate-the-transmissibility-for-an-influenza-pandemic
#11
Ka Chun Chong, Benny Chung Ying Zee, Maggie Haitian Wang
BACKGROUND: In a new influenza pandemic, travel data such as arrival times of cases seeded by the originating country can be regarded as a combination of the epidemic size and the mobility networks of infections connecting the originating country with other regions. It can be a complete and timely source for estimating the basic reproduction number (R 0 ), a key indicator of disease transmissibility. METHOD: In this study, we developed a likelihood-based method using arrival times of infected cases in different countries to estimate R 0 for influenza pandemics...
February 21, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28222127/unusual-pattern-of-chikungunya-virus-epidemic-in-the-americas-the-panamanian-experience
#12
Jean-Paul Carrera, Yamilka Díaz, Bernardino Denis, Itza Barahona de Mosca, Dennys Rodriguez, Israel Cedeño, Dimelza Arauz, Publio González, Lizbeth Cerezo, Lourdes Moreno, Lourdes García, Lisseth E Sáenz, María Aneth Atencio, Eddy Rojas-Fermin, Fernando Vizcaino, Nicolas Perez, Brechla Moreno, Sandra López-Vergès, Anayansi Valderrama, Blas Armién
BACKGROUND: Chikungunya virus (CHIKV) typically causes explosive epidemics of fever, rash and polyarthralgia after its introduction into naïve populations. Since its introduction in Panama in May of 2014, few autochthonous cases have been reported; most of them were found within limited outbreaks in Panama City in 2014 and Puerto Obaldia town, near the Caribbean border with Colombia in 2015. In order to confirm that Panama had few CHIKV cases compared with neighboring countries, we perform an epidemiological analysis of chikungunya cases reported from May 2014 to July 2015...
February 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28219161/-advances-on-epidemiological-research-of-human-infections-with-novel-avian-influenza-a-h7n9-virus
#13
Q M Wang, S L Liu, E F Chen
Human infections with novel avian influenza A(H7N9)virus was an emerging infectious disease discovered in March, 2013. As of June30, 2016, 770 cases of H7N9 were reported in worldwide including 315 deaths with 40.9% of high case fatality rate. Yangtze River Delta and Pearl River Delta were the high-prevalence area. Formerly, the cases of H7N9 were concentrated on the municipalities. However, most of the case-patients were from smaller cities or rural areas nowadays. The H7N9 human infections mainly occurred in winter and spring every waves as similar as seasonal and H5N1 human infections...
February 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28219024/is-tetraethyl-lead-poison-affecting-contemporary-indigenous-suicides-in-ontario-canada
#14
Trehani Mary Fonseka, Gerald P McKinley, Sidney H Kennedy
Prior to the mid-1980s, suicide in Indigenous population in Northwestern Ontario, Canada, was rare, occurring at rates of 1-2 per year among over 20 communities. By the early 1990s, the completed suicide rates in the same communities were among the highest in the world. Prior to the outbreak of the suicide epidemic, sniffing of gasoline containing tetraethyl was common in many communities. Existing literature confirms that tetraethyl lead poisoning is associated with alterations to the amyloid-β protein precursor and amyloid-β as well as the 5-HT-1B receptor...
January 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28217934/population-dynamics-of-wild-rodents-induce-stochastic-fadeouts-of-a-zoonotic-pathogen
#15
Giorgio Guzzetta, Valentina Tagliapietra, Sarah E Perkins, Heidi C Hauffe, Piero Poletti, Stefano Merler, Annapaola Rizzoli
Stochastic processes play an important role in the infectious disease dynamics of wildlife, especially in species subject to large population oscillations. Here we study the case of a free ranging population of yellow-necked mice (Apodemus flavicollis) in northern Italy, where circulation of Dobrava-Belgrade hantavirus (DOBV) has been detected intermittently since 2001, until an outbreak emerged in 2010. We analyzed the transmission dynamics of the recent outbreak using a computational model that accounts for seasonal changes of the host population and territorial behavior...
February 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28216186/demographics-epidemiology-and-the-impact-of-vaccination-campaigns-in-a-measles-free-world-can-elimination-be-maintained
#16
J M Prada, C J E Metcalf, S Takahashi, J Lessler, A J Tatem, M Ferrari
INTRODUCTION: All six WHO regions currently have goals for measles elimination by 2020. Measles vaccination is delivered via routine immunization programmes, which in most sub-Saharan African countries reach children around 9months of age, and supplementary immunization activities (SIAs), which target a wider age range at multi-annual intervals. In the absence of endemic measles circulation, the proportion of individuals susceptible to measles will gradually increase through accumulation of new unvaccinated individuals in each birth cohort, increasing the risk of an epidemic...
February 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28215187/experiences-of-ebola-survivors-causes-of-distress-and-sources-of-resilience
#17
Patricia M Schwerdtle, Veronique De Clerck, Virginia Plummer
: Introduction An appreciation of the experience of Ebola survivors is critical for community engagement and an effective outbreak response. Few qualitative, descriptive studies have been conducted to date that concentrate on the voices of Ebola survivors. Problem This study aimed to explore the experiences of Ebola survivors following the West African epidemic of 2014. METHOD: An interpretive, qualitative design was selected using semi-structured interviews as the method of data collection...
February 20, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28213873/first-isolation-and-genetic-characteristics-of-porcine-sapeloviruses-in-hunan-china
#18
Taotao Yang, Runcheng Li, Wang Peng, Meng Ge, Binyu Luo, Tailong Qu, Xinglong Yu
Outbreaks of diarrhea in piglets cause serious economic consequences in China. Diarrhetic fecal samples from 20 Hunan farm piglets were tested and found to be positive for porcine epidemic diarrhea virus (PEDV) by RT-PCR, although incubation with porcine kidney (PK-15) cells failed to produce infectious PEDV. Four porcine sapelovirus (PSV) strains (designated as PSV-HuNs) were isolated from four of the samples. Genomic sequence analysis revealed open reading frames encoding polyproteins of 2,331 (HuN1, 2 and 3) and 2,332 (HuN4) amino acids...
February 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28212379/distribution-and-abundance-of-key-vectors-of-rift-valley-fever-and-other-arboviruses-in-two-ecologically-distinct-counties-in-kenya
#19
Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander
BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis of ruminants and humans that causes outbreaks in Africa and the Arabian Peninsula with significant public health and economic consequences. Humans become infected through mosquito bites and contact with infected livestock. The virus is maintained between outbreaks through vertically infected eggs of the primary vectors of Aedes species which emerge following rains with extensive flooding. Infected female mosquitoes initiate transmission among nearby animals, which amplifies virus, thereby infecting more mosquitoes and moving the virus beyond the initial point of emergence...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28207932/detecting-signals-of-chronic-shedding-to-explain-pathogen-persistence-leptospira-interrogans-in-california-sea-lions
#20
M G Buhnerkempe, K C Prager, C C Strelioff, D J Greig, J L Laake, S R Melin, R L DeLong, F M D Gulland, J O Lloyd-Smith
Identifying mechanisms driving pathogen persistence is a vital component of wildlife disease ecology and control. Asymptomatic, chronically infected individuals are an oft-cited potential reservoir of infection but demonstrations of the importance of chronic shedding to pathogen persistence at the population level remain scarce. Studying chronic shedding using commonly collected disease data is hampered by numerous challenges, including short-term surveillance that focuses on single epidemics and acutely ill individuals, the subtle dynamical influence of chronic shedding relative to more obvious epidemic drivers, and poor ability to differentiate between the effects of population prevalence of chronic shedding versus intensity and duration of chronic shedding in individuals...
February 16, 2017: Journal of Animal Ecology
keyword
keyword
47392
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"