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https://www.readbyqxmd.com/read/28100231/can-screening-instruments-accurately-determine-poor-outcome-risk-in-adults-with-recent-onset-low-back-pain-a-systematic-review-and-meta-analysis
#1
Emma L Karran, James H McAuley, Adrian C Traeger, Susan L Hillier, Luzia Grabherr, Leslie N Russek, G Lorimer Moseley
BACKGROUND: Delivering efficient and effective healthcare is crucial for a condition as burdensome as low back pain (LBP). Stratified care strategies may be worthwhile, but rely on early and accurate patient screening using a valid and reliable instrument. The purpose of this study was to evaluate the performance of LBP screening instruments for determining risk of poor outcome in adults with LBP of less than 3 months duration. METHODS: Medline, Embase, CINAHL, PsycINFO, PEDro, Web of Science, SciVerse SCOPUS, and Cochrane Central Register of Controlled Trials were searched from June 2014 to March 2016...
January 19, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28100201/developing-a-practice-guideline-for-the-occupational-health-services-by-using-a-community-of-practice-approach-a-process-evaluation-of-the-development-process
#2
Lydia Kwak, Charlotte Wåhlin, Kjerstin Stigmar, Irene Jensen
BACKGROUND: One way to facilitate the translation of research into the occupational health service practice is through clinical practice guidelines. To increase the implementability of guidelines it is important to include the end-users in the development, for example by a community of practice approach. This paper describes the development of an occupational health practice guideline aimed at the management of non-specific low back pain (LBP) by using a community of practice approach...
January 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28098741/does-familial-aggregation-of-chronic-low-back-pain-impact-on-recovery-a-population-based-twin-study
#3
J R Zadro, D Shirley, J F Sanchez-Romera, J R Ordoñana, P H Ferreira
STUDY DESIGN: Longitudinal twin-cohort study. OBJECTIVE: To investigate the impact familial aggregation of chronic low back pain (LBP) has on the recovery from chronic LBP. SUMMARY OF BACKGROUND DATA: LBP is a worldwide problem, with pain and disability often becoming chronic. Genetics and familial behaviours could significantly impact the recovery from chronic LBP but have not been extensively investigated. METHODS: 624 Spanish twins from the Murcia Twin Registry reported experiencing chronic LBP within the past two years during the 2009/11 data collection wave and were followed up in 2013...
January 16, 2017: Spine
https://www.readbyqxmd.com/read/28097246/three-year-follow-up-of-a-randomized-controlled-trial-comparing-preoperative-neuroscience-education-for-patients-undergoing-surgery-for-lumbar-radiculopathy
#4
Adriaan Louw, Ina Diener, Merrill R Landers, Kory Zimney, Emilio J Puentedura
BACKGROUND: Results from a previous multicenter randomized controlled trial (RCT) on preoperative pain neuroscience education (PNE) for lumbar radiculopathy found no significant difference in patient reported outcomes between groups. However, patients who received PNE viewed their surgical experience more favorably and utilized significantly less healthcare compared to those that did not. The purpose is to determine if the reduction in healthcare costs from 1-year would be continued at 3-year following surgery, and to explore differences (if any) in patient reported outcomes...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28096690/the-relationship-between-findings-on-magnetic-resonance-imaging-and-previous-history-of-low-back-pain
#5
Juichi Tonosu, Hiroyuki Oka, Ko Matsudaira, Akiro Higashikawa, Hiroshi Okazaki, Sakae Tanaka
The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one participants without current LBP were included. Sagittal T2-weighted MRI was used to assess the intervertebral space from T12/L1 to L5/S1. These images were classified into five grades based on the Pfirrmann grading system...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28095892/comparative-effectiveness-and-cost-effectiveness-of-chuna-manual-therapy-versus-conventional-usual-care-for-nonacute-low-back-pain-study-protocol-for-a-pilot-multicenter-pragmatic-randomized-controlled-trial-pcrn-study
#6
Byung-Cheul Shin, Me-Riong Kim, Jae-Heung Cho, Jae-Young Jung, Koh-Woon Kim, Jun-Hwan Lee, Kibong Nam, Min Ho Lee, Eui-Hyoung Hwang, Kwang-Ho Heo, Namkwen Kim, In-Hyuk Ha
BACKGROUND: While Chuna manual therapy is a Korean manual therapy widely used primarily for low back pain (LBP)-related disorders in Korea, well-designed studies on the comparative effectiveness of Chuna manual therapy are scarce. METHODS/DESIGN: This study is the protocol for a three-armed, multicenter, pragmatic randomized controlled pilot trial. Sixty severe nonacute LBP patients (pain duration of at least 3 weeks, Numeric Rating Scale (NRS) ≥5) will be recruited at four Korean medicine hospitals...
January 17, 2017: Trials
https://www.readbyqxmd.com/read/28092545/heterogeneous-face-recognition-a-common-encoding-feature-discriminant-approach
#7
Dihong Gong, Zhifeng Li, Weilin Huang, Xuelong Li, Dacheng Tao
Heterogeneous face recognition is an important yet challenging problem in face recognition community. It refers to matching a probe face image to a gallery of face images taken from alternate imaging modality. The major challenge of heterogeneous face recognition lies in the great discrepancies between different image modalities. Conventional face feature descriptors, e.g. LBP, HOG and SIFT, are mostly designed in a handcrafted way and thus generally fail to extract the common discriminant information from the heterogeneous face images...
January 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28089347/virtual-screening-and-experimental-validation-identify-novel-modulators-of-nuclear-receptor-rxr%C3%AE-from-drugbank-database
#8
Dan Xu, Lijun Cai, Shangjie Guo, Lei Xie, Meimei Yin, Ziwen Chen, Hu Zhou, Ying Su, Zhiping Zeng, Xiaokun Zhang
Retinoid X receptor alpha (RXRα), an important ligand-dependent transcription factor, plays a critical role in the development of various cancers and metabolic and neurodegenerative diseases. Therefore, RXRα represents one of the most important targets in modern drug discovery. In this study, Drugbank 2.0 with 1280 old drugs were virtually screened by Glide according to the crystal structure of ligand-binding domain (LBP) of RXRα. 15 compounds selected were tested for their binding and transcriptional activity toward RXRα by Biacore and reporter gene assay, respectively...
December 26, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28087847/addressing-disparities-in-low-back-pain-care-by-developing-culturally-appropriate-information-for-aboriginal-australians-my-back-on-track-my-future
#9
Ivan B Lin, Kim Ryder, Juli Coffin, Charmaine Green, Eric Dalgety, Brian Scott, Leon M Straker, Anne J Smith, Peter B O'Sullivan
OBJECTIVES : Addressing disparities in low back pain care (LBP) is an important yet largely unaddressed issue. One avenue to addressing disparities, recommended by clinical guidelines, is to ensure that LBP information is culturally appropriate. Our objectives were, first, to develop LBP information that was culturally appropriate for Aboriginal Australians living in a rural area and, second, to compare this to traditional information. METHODS : The overall information development process was guided by a "cultural security" framework and included partnerships between Aboriginal/non-Aboriginal investigators, a synthesis of research evidence, and participation of a project steering group consisting of local Aboriginal people...
January 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28087062/timing-and-magnitude-of-lumbar-spine-contribution-to-trunk-forward-bending-and-backward-return-in-patients-with-acute-low-back-pain
#10
Iman Shojaei, Milad Vazirian, Elizabeth G Salt, Linda R Van Dillen, Babak Bazrgari
Alterations in the lumbo-pelvic coordination denote changes in neuromuscular control of trunk motion as well as load sharing between passive and active tissues in the lower back. Differences in timing and magnitude aspects of lumbo-pelvic coordination between patients with chronic low back pain (LBP) and asymptomatic individuals have been reported; yet, the literature on lumbo-pelvic coordination in patients with acute LBP is scant. A case-control study was conducted to explore the differences in timing and magnitude aspects of lumbo-pelvic coordination between females with (n=19) and without (n=19) acute LBP...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28079724/explaining-how-cognitive-behavioural-approaches-work-for-low-back-pain-mediation-analysis-of-the-back-skills-training-trial
#11
Bethany Fordham, Chen Ji, Zara Hansen, Ranjit Lall, Sarah E Lamb
STUDY DESIGN: .: This is secondary research examining the longitudinal mediation effect within a structural equation model. OBJECTIVE: .: To identify possible mechanisms which mediate the effects of a cognitive behavioural approach upon disability and pain in low back pain patients. SUMMARY OF BACKGROUND DATA: .: Cognitive behavioural interventions (CBIs) can improve pain and disability in low back pain (LBP) but the mechanisms of action are unclear...
January 10, 2017: Spine
https://www.readbyqxmd.com/read/28078869/high-level-laser-therapy-for-the-treatment-of-lower-back-pain-clinical-efficacy-and-comparison-of-different-wavelengths
#12
A Notarnicola, G Maccagnano, S Tafuri, M F Gallone, L Moretti, B Moretti
High energy laser therapy (HELT) could be a new alternative treatment for lower back pain (LBP), which is a significant public health problem. Nevertheless, differences between the various light waves of HELT have not yet been fully researched. Sixty-six patients with lower back pain were treated using a high energy laser therapy. They were randomized into three different protocols which differed according to wave length (650 nm, 810 nm and TRIAX, which is simultaneous emission of 810 nm, 980 nm e 1064 nm)...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28076310/the-serum-concentrations-of-leptin-and-mcp-1-independently-predict-low-back-pain-duration
#13
Giuseppe Lippi, Concetta Dagostino, Ruggero Buonocore, Rosalia Aloe, Chiara Bonaguri, Guido Fanelli, Massimo Allegri
BACKGROUND: Low back pain (LBP) is a very frequent condition, affecting most people at some point throughout their life. This cross-sectional study was aimed to investigate a selected panel of cytokines and inflammatory biomarkers in patients with or without LBP. METHODS: The study population consisted of 104 patients diagnosed with LBP (52 non-persistent and 52 persistent) and 52 healthy subjects with no LBP. Blood samples were collected for assessment of adiponectin, leptin, monocyte chemoattractant protein-1 (MCP-1) and C reactive protein (CRP)...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28073798/effectiveness-of-a-lumbopelvic-monitor-and-feedback-device-to-change-postural-behaviour-a-protocol-for-the-elf-cluster-randomised-controlled-trial
#14
Daniel Cury Ribeiro, Stephan Milosavljevic, J Haxby Abbott
INTRODUCTION: Low back pain (LBP) is the most common, costly and disabling musculoskeletal disorder worldwide, and is prevalent in healthcare workers. Posture is a modifiable risk factor for LBP shown to reduce the prevalence of LBP. Our feasibility research suggests that postural feedback might help healthcare workers avoid hazardous postures. The Effectiveness of Lumbopelvic Feedback (ELF) trial will investigate the extent to which postural monitor and feedback (PMF) can reduce exposure to hazardous posture associated with LBP...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28073085/effect-of-investigator-observation-on-gait-parameters-in-individuals-with-and-without-chronic-low-back-pain
#15
Joshua Vickers, Austin Reed, Robert Decker, Bryan P Conrad, Marissa Olegario-Nebel, Heather K Vincent
Despite the ubiquity of gait assessment in clinic and research, it is unclear how observation impacts gait, particularly in persons with chronic pain and psychological stress. We compared temporal spatial gait patterns in people with and without chronic low back pain (CLBP) when they were aware and unaware of being observed. This was a repeated-measures, deception study in 55 healthy persons (32.0±12.4 yr, 24.2±2.7kg/m(2)) and persons with CLBP (51.9±17.9 yr, 27.8±4.4kg/m(2)). Participants performed one condition in which they were unaware of observation (UNW), and three conditions under investigator observation: (1) aware of observation (AWA), (2) investigators watching cadence, (3) investigators watching step length...
January 3, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28068962/correlation-between-lumbar-dysfunction-and-fat-infiltration-in-lumbar-multifidus-muscles-in-patients-with-low-back-pain
#16
Markus Hildebrandt, Gabriela Fankhauser, André Meichtry, Hannu Luomajoki
BACKGROUND: Lumbar multifidus muscles (LMM) are important for spinal motion and stability. Low back pain (LBP) is often associated with fat infiltration in LMM. An increasing fat infiltration of LMM may lead to lumbar dysfunction. The purpose of this study was to investigate whether there is a correlation between the severity of lumbar dysfunction and the severity of fat infiltration of LMM. METHODS: In a cross-sectional study, 42 patients with acute or chronic LBP were recruited...
January 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28061508/structure-based-understanding-of-binding-affinity-and-mode-of-estrogen-receptor-%C3%AE-agonists-and-antagonists
#17
Sehan Lee, Mace G Barron
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interactions and specific hydrogen bonds with the ligand. Here we present a framework for quantitative analysis of the steric and electronic features of the human ERα-ligand complex using three dimensional (3D) protein-ligand interaction description combined with 3D-QSAR approach...
2017: PloS One
https://www.readbyqxmd.com/read/28061494/prevalence-and-risk-factors-for-lumbar-spondylosis-and-its-association-with-low-back-pain-among-rural-korean-residents
#18
Sung Yeon Lee, Nam H Cho, Young Ok Jung, Young Il Seo, Hyun Ah Kim
OBJECTIVE: The purpose of this study was to investigate the prevalence of and the relevant risk factors for lumbar spondylosis (LS) among middle-aged and elderly rural Korean residents and to explore the association between radiographic LS and lower back pain (LBP) in relation to age and gender. METHODS: This community-based, cross-sectional study evaluated 1512 subjects with available radiograph. The prevalence of LBP was obtained using a questionnaire and disability resulting from LBP was measured using a validated Korean version of the Oswestry disability index (ODI)...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28059499/inactivation-of-the-nuclear-orphan-receptor-coup-tfii-by-small-chemicals
#19
Rémy Le Guével, Frédérik Oger, Celia P Martinez-Jimenez, Maud Bizot, Céline Gheeraert, François Firmin, Maheul Ploton, Miroslava Kretova, Gaëlle Palierne, Bart Staels, Peter Barath, Iannis Talianidis, Philippe Lefebvre, Jérôme Eeckhoute, Gilles Salbert
Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII/NR2F2) is an orphan member of the nuclear receptor family of transcription factors whose activities are modulated upon binding of small molecules into an hydrophobic ligand-binding pocket (LBP). Although the LBP of COUP-TFII is filled with aromatic amino-acid side chains, alternative modes of ligand binding could potentially lead to regulation of the orphan receptor. Here, we screened a synthetic and natural compound library in a yeast one-hybrid assay and identified 4-methoxynaphthol as an inhibitor of COUP-TFII...
January 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28048213/mo-de-207a-09-low-dose-ct-image-reconstruction-via-learning-from-different-patient-normal-dose-images
#20
H Han, L Xing, Z Liang
PURPOSE: To investigate a novel low-dose CT (LdCT) image reconstruction strategy for lung CT imaging in radiation therapy. METHODS: The proposed approach consists of four steps: (1) use the traditional filtered back-projection (FBP) method to reconstruct the LdCT image; (2) calculate structure similarity (SSIM) index between the FBP-reconstructed LdCT image and a set of normal-dose CT (NdCT) images, and select the NdCT image with the highest SSIM as the learning source; (3) segment the NdCT source image into lung and outside tissue regions via simple thresholding, and adopt multiple linear regression to learn high-order Markov random field (MRF) pattern for each tissue region in the NdCT source image; (4) segment the FBP-reconstructed LdCT image into lung and outside regions as well, and apply the learnt MRF prior in each tissue region for statistical iterative reconstruction of the LdCT image following the penalized weighted least squares (PWLS) framework...
June 2016: Medical Physics
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