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Lindsay M Fox, Mikiko Murakami, Houman Danesh, Alex F Manini
INTRODUCTION: Battlefield acupuncture (BFA) is an ear acupuncture protocol used by the military for immediate pain relief. This is a pilot feasibility study of BFA as a treatment for acute low back pain (LBP) in the emergency department (ED). METHODS: Thirty acute LBP patients that presented to ED were randomized to standard care plus BFA or standard care alone. In the BFA group, outcomes were assessed at the time of randomization, 5 min after intervention, and again within 1 h after intervention...
February 27, 2018: American Journal of Emergency Medicine
Alessandra Masci, Simone Carradori, Maria Antonietta Casadei, Patrizia Paolicelli, Stefania Petralito, Rino Ragno, Stefania Cesa
In the last decades, glycoconjugates from Lycium barbarum L. fruit (Goji berry) have received a great attention for their potential health-promoting effects. The present review includes a survey of extraction and purification methods of these bioactive molecules (L. barbarum polysaccharides, LBPs), along with a dissertation on the structural characterisation of the carbohydrate component. Furthermore, an overview of in vitro, in vivo and clinical studies concerning the hypoglycaemic and hypolipidaemic effects of isolated LBP fractions, is reported...
July 15, 2018: Food Chemistry
Nicolas Daffern, Zhonglei Chen, Yongbo Zhang, Leslie Pick, Ishwar Radhakrishnan
The ligand-binding domains (LBD) of the NR5A subfamily of nuclear receptors activate transcription via ligand-dependent and ligand-independent mechanisms. The Drosophila Ftz-F1 receptor (NR5A3) belongs to the latter category and its ligand-independence is attributed to a short helical segment (6) within the protein that resides in the canonical ligand-binding pocket (LBP) in the crystalline state. Here, we show that the 6 helix is dynamic in solution when Ftz-F1 is bound to the LxxLL motif of its cofactor Ftz, undergoing motions on the fast (picosecond-nanosecond) as well as slow (microsecond-millisecond) timescales...
March 16, 2018: Biochemistry
Lin Shen, Yinghua Wu, Liang Han, Haiying Zhang
Low back pain (LBP) is one of the most common musculoskeletal diseases in the world. The incidence is ~70% in adults and many of them suffer from disability. Recently, intervertebral disc degeneration (IDD) has been deemed as a main cause of LBP. The present study aimed to investigate the potentials of growth and differentiation factor-5 (GDF-5) in IDD. The protein levels of prostaglandin-E2 (PGE2), tumor necrosis factor (TNF)-α and interleukin (IL)-1β in culture medium were evaluated by ELISA. mRNA and protein expression levels in nucleus pulposus (NP) cells were evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting, respectively...
April 2018: Experimental and Therapeutic Medicine
Rashmi Panda, N B Puhan, Aparna Rao, Debananda Padhy, Ganapati Panda
Retinal nerve fiber layer defect (RNFLD) provides an early objective evidence of structural changes in glaucoma. RNFLD detection is currently carried out using imaging modalities like OCT and GDx which are expensive for routine practice. In this regard, we propose a novel automatic method for RNFLD detection and angular width quantification using cost effective redfree fundus images to be practically useful for computer-assisted glaucoma risk assessment. After blood vessel inpainting and CLAHE based contrast enhancement, the initial boundary pixels are identified by local minima analysis of the 1-D intensity profiles on concentric circles...
March 6, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
Mette Korshøj, Marie Birk Jørgensen, David M Hallman, Julie Lagersted-Olsen, Andreas Holtermann, Nidhi Gupta
Objective Low-back pain (LBP) is a massive health problem. Sitting at work has been suggested to be both a risk and protective factor for LBP. Thus, the objective of this study was to investigate the association between total and temporal patterns of objectively measured sitting duration and individual time course of LBP. Methods The analysis was performed among 665 participants from the DPhacto cohort of mainly blue-collar workers. Sitting at work was measured by accelerometry at baseline, expressed in total duration and temporal pattern [% of working time spent in brief bursts (≤5 minutes), moderate (>5 - ≤20 minutes) and prolonged periods (>20 minutes)] of sitting...
March 15, 2018: Scandinavian Journal of Work, Environment & Health
R Bonsale, R Seyed Sharifi, E Dirandeh, N Hedayat, A Mojtahedin, M Ghorbanalinia, A Abolghasemi
The objective of this study was to consider endocannabinoid system as inflammatory markers in bovine endometrium to better understand the role of this system in regulating many of the functions that are related to inflammatory condition. At day 26 post-partum, fourteen cows were divided into two groups depending on the inflammatory condition: 1- subclinical endometritis (n = 7, with purulent or mucopurulent uterine discharge detectable in the vagina) and 2- healthy (n = 7, No (muco)) purulent discharge...
March 14, 2018: Reproduction in Domestic Animals, Zuchthygiene
Davood Afshari, Seyed Mahmood Latifi, Samira Kord, Maryam Nourollahi-Darabad
In 2011, load limits for manual lifting were adopted in Iran to protect workers from low back injury without prior testing of accuracy with Iranian workers. This investigation examined how accurate the adopted ACGIH TLVs at the allowable limits predict risk for LBP disorders for a group of Iranian workers using biomechanical criteria. Testing took place in the laboratory with participants completing a series of 2-handed lifting tasks as defined in the Iranian Guideline for Manual Lifting. To test accuracy, both compression and shear forces were estimated for fifteen male Iranian workers who completed 25 lift combinations that varied in height and reach with the maximal allowable load...
March 13, 2018: Industrial Health
Rodrigo Dalke Meucci, Angélica Ozório Linhares, Daniel Wenceslau Votto Olmedo, Ewerton Luiz Porto Cousin Sobrinho, Vlanice Madruga Duarte, Juraci Almeida Cesar
The scope of this article is to assess low back pain prevalence and associated factors in the last 12 months among adolescents in a city in the south of the State of Piauí. It was a cross-sectional study which included 1,112 adolescents aged 13-19 in the city of Caracol, Piauí. Demographic, socio-economic, nutritional, behavioral and comorbidty characteristics were investigated. The outcome was the occurrence of low back pain (LBP) in the last 12 months. The outcome prevalence was calculated in accordance with independent variables...
March 2018: Ciência & Saúde Coletiva
Monica Teng, Hui Jun Zhou, Liang Lin, Pang Hung Lim, Doreen Yeo, Suzanne Goh, Soon Yin Tjan, Boon Peng Lim
Background: The study evaluated the cost-effectiveness of hydrotherapy versus land-based therapy in patients with musculoskeletal disorders (MSDs) in Singapore. Methods: A decision-analytic model was constructed to compare the cost-effectiveness of hydrotherapy to land-based therapy over 3 months from societal perspective. Target population comprised patients with low back pain (LBP), osteoarthritis (OA), rheumatoid arthritis (RA), total hip replacement (THR) and total knee replacement (TKR)...
March 9, 2018: Journal of Public Health
Kessarawan Nilvarangkul, Teerasak Phajan, WongsaLAOHASIRIWONG, John F Smith, Dariwan Settheetham
This cross sectional study developed and validated a LBP risk-factor screening scale for use with sugarcane farmers. The scale was developed from a synthesis of LBP risk factors, pretested with 30 sugarcane farmers and administered to five hundred and forty sugarcane farmers to test its psychometric properties. Results indicated construct validity for three factors; physical factors (19 items) with factor loadings of 0.406 to 0.881 and communalities between 0.471 and 0.991; psychological factors (7 items) with factor loadings of 0...
March 10, 2018: Industrial Health
Ruijun He, Min Cui, Hui Lin, Lei Zhao, Jiayu Wang, Songfeng Chen, Zengwu Shao
AIMS: Intervertebral disc degeneration (IVDD) is thought to be the major cause of low back pain (LBP), which is still in lack of effective etiological treatment. Oxidative stress has been demonstrated to participate in the impairment of nucleus pulposus cells (NPCs). As the most important neuroendocrine hormone in biological clock regulation, melatonin (MLT) is also featured by good antioxidant effect. In this study, we investigated the effect and mechanisms of melatonin on oxidative stress-induced damage in rat NPCs...
March 8, 2018: Life Sciences
Adam W A Geraghty, Rosie Stanford, Beth Stuart, Paul Little, Lisa C Roberts, Nadine E Foster, Jonathan C Hill, Elaine M Hay, David Turner, Wansida Malakan, Linda Leigh, Lucy Yardley
OBJECTIVE: To determine the feasibility of a randomised controlled trial of an internet intervention for low back pain (LBP) using three arms: (1) usual care, (2) usual care plus an internet intervention or (3) usual care plus an internet intervention with additional physiotherapist telephone support. DESIGN AND SETTING: A three-armed randomised controlled feasibility trial conducted in 12 general practices in England. PARTICIPANTS: Primary care patients aged over 18 years, with current LBP, access to the internet and without indicators of serious spinal pathology or systemic illness...
March 9, 2018: BMJ Open
Yuko Hashimoto, Ko Matsudaira, Susumu S Sawada, Yuko Gando, Ryoko Kawakami, Robert A Sloan, Chihiro Kinugawa, Takashi Okamoto, Koji Tsukamoto, Motohiko Miyachi, Hisashi Naito
BACKGROUND: The relationship between the combination of physical activity (PA) and body mass index (BMI) with low back pain (LBP) is unclear. The present study offers a cross-sectional assessment of how combinations of PA and BMI are related to LBP in Japanese men. METHODS: Participants were 4022 Japanese men (mean age = 47) who underwent regular clinical examinations. PA was measured using a uniaxial accelerometer and divided into tertiles (PAhigh , PAmiddle , PAlow )...
March 9, 2018: BMC Public Health
Audrey Petit, Cyril Begue, Isabelle Richard, Yves Roquelaure
OBJECTIVES: To assess the attitudes and beliefs of physiotherapists (PTs) regarding the management of chronic LBP and to investigate the factors which influence them. METHODS: A cross-sectional study conducted in the French Loire Valley region by a questionnaire sent to the private PTs between June and September 2014. Demographic data and modalities of practices were collected in association with the Pain Attitudes and Beliefs Scale (PABS) which is a specific self-administered questionnaire designed to assess the "biomedical" or "behavioral" (i...
March 9, 2018: Physiotherapy Theory and Practice
Mengxia Wang, Yongxiong Chen, Yuanyuan Wang, Yuan Li, Haihui Zheng, Fangli Ma, ChungWah Ma, Xiaojun Zhang, Biyu Lu, Zhiyong Xie, Qiongfeng Liao
Weaning is an essential and important event for infants and rodent animals, and the dietary supplementation plays a crucial role in regulating the composition and function of gut microbiota in the initial period after weaning. In this study, we investigated the potential effects of two probiotics along with three polysaccharides (PP) in weaned rats. Male SD rats, 21 days of age, were divided into two groups: one group was administered with PP for four weeks and the other was not. Body weight, food intake, gut epithelial barrier function, digestive enzyme activities, and the composition and function of gut microbiota were analyzed...
March 9, 2018: Food & Function
Xuanqi Xiong, Zhengwei Zhou, Matteo Figini, Junjie Shangguan, Zhuoli Zhang, Wei Chen
Objective: To quantitatively evaluate lumbar disc degeneration with recently-developed quantitative magnetic resonance imaging (MRI) techniques. A series of MRI parameters, including T2*, T1rho relaxation time, apparent diffusion coefficient and gagCEST, were compared and correlated with the Pfirrmann semi-quantitative classification of lumbar intervertebral disc degeneration; the most accurate and relevant MRI parameters of lumbar disc degeneration were identified. Materials and Methods: Thirty-seven subjects (age range, 18-74 years) with non-specific low back pain (LBP) for more than 6 months were enrolled...
2018: American Journal of Translational Research
Nicola Holt, Gemma Mansell, Jonathan C Hill, Tamar Pincus
OBJECTIVES: Reassurance is an essential part of treatment for low back pain (LBP), but evidence on effective methods to deliver reassurance remains scarce. The interaction between consultation-based reassurance and patients' psychological risk is unknown. Our objective was to investigate the relationship between consultation-based reassurance and clinical outcomes at follow-up, in people with and without psychological risk. METHODS: We tested the associations between specific reassurance components (data gathering, relationship building, generic reassurance, and cognitive reassurance), patients' psychological risk (the presence of depression, anxiety, catastrophizing, or fear-avoidance), and postconsultation outcomes including, satisfaction and enablement, disability, pain, and mood at 3-month follow-up...
April 2018: Clinical Journal of Pain
Clark R Dickerson, Talia Alenabi, Bernard J Martin, Don B Chaffin
This study aimed to compare the activity of four shoulder muscles in individuals with low back pain (LBP), spinal cord injuries (SCI) and a control group, during one-handed load transfer trials. Nine individuals with minimum one-year of LBP, eleven with thoracic/lumbar SCI and nine healthy controls participated in this study. The activations of anterior deltoid, upper trapezius, infraspinatus and pectoralis major were recorded by surface EMG during one-handed transferring of a cylinder from a home shelve to six spatially distributed target shelves...
March 8, 2018: Ergonomics
Kenji Miki, Tatsunori Ikemoto, Kazuhiro Hayashi, Young-Chang Arai, Miho Sekiguchi, Kenrin Shi, Takahiro Ushida
BACKGROUND: Current worldwide clinical practice guidelines recommend acetaminophen as the first option for the treatment of acute low back pain. However, there is no concrete evidence regarding whether acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) is more effective for treating acute low back pain (LBP) in Japan. The present study aimed to investigate whether acetaminophen treatment for acute musculoskeletal pain was comparable with loxoprofen (a traditional NSAID in Japan) treatment...
March 1, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
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