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https://www.readbyqxmd.com/read/28655129/pain-related-fear-of-re-injury-in-patients-with-low-back-pain-estimation-or-measurement-in-manual-therapy-primary-care-practice-a-pilot-study
#1
Rob A B Oostendorp, Hans Elvers, Emilia Mikolajewska, Marjan Laekeman, Nathalie Roussel, Olaf van der Zanden, Jo Nijs, Han Samwel
BACKGROUND: Manual physical therapists (MPTs) working in primary care get limited information about patient's courses of (chronic) low back pain (LBP). Identification of kinesiophobia is mostly based on clinical perception. OBJECTIVE: The aim of this study was to evaluate the association between the scores with which manual physical therapists in a primary care setting identify kinesiophobia in patients with low back pain, and the patients' self-reported measures of kinesiophobia...
June 2, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28655123/mechanical-low-back-pain-in-elite-track-and-field-athletes-an-observational-cohort-study
#2
Nikolaos Malliaropoulos, Georgios Bikos, Maria Meke, Ioannis Tsifountoudis, Dev Pyne, Vasileios Korakakis
OBJECTIVE: The aim of the study was to gain information about the incidence of mechanical Low Back Pain (MLBP) injuries etiology in elite track and field athletes and to assess the recurrence rate. BACKGROUND: The prevalence and the etiology of Low Back Pain (LBP) in athletic populations at the elite level of competition lack of longitudinal studies focused on certain sport fields. The present study evaluates MLBP incidents in elite track and field athletes visiting National Track and Field Centre in Thessaloniki, Greece and classifies MLBP according to etiology...
June 2, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28652802/comparison-of-quadrapolar%C3%A2-radiofrequency-lesions-produced-by-standard-versus-modified-technique-an-experimental-model
#3
Ramin Safakish
Lower back pain (LBP) is a global public health issue and is associated with substantial financial costs and loss of quality of life. Over the years, different literature has provided different statistics regarding the causes of the back pain. The following statistic is the closest estimation regarding our patient population. The sacroiliac (SI) joint pain is responsible for LBP in 18%-30% of individuals with LBP. Quadrapolar™ radiofrequency ablation, which involves ablation of the nerves of the SI joint using heat, is a commonly used treatment for SI joint pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28652204/evidence-for-a-role-of-nerve-injury-in-painful-intervertebral-disc-degeneration-a-cross-sectional-proteomic-analysis-of-human-cerebrospinal-fluid
#4
Tony K Y Lim, Kathleen M Anderson, Pawan Hari, Marcos Di Falco, Troy E Reihsen, George L Wilcox, Kumar G Belani, Sylvie LaBoissiere, Manuel R Pinto, David S Beebe, Lois Kehl, Laura S Stone
Intervertebral disc degeneration (DD) is a cause of low back pain (LBP) in some individuals. However, while >30% of adults have DD, LBP only develops in a subset of individuals. To gain insight into the mechanisms underlying non-painful versus painful DD, human cerebrospinal fluid (CSF) was examined using differential expression shotgun proteomic techniques comparing healthy controls, subjects with non-painful DD, and patients with painful DD scheduled for spinal fusion surgery. Eighty-eight proteins were detected, 27 of which were differentially expressed...
June 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28651304/rifaximin-and-propranolol-combination-therapy-is-more-effective-than-propranolol-monotherapy-for-the-reduction-of-portal-pressure-an-open-randomized-controlled-pilot-study
#5
Yoo Li Lim, Moon Young Kim, Yoon Ok Jang, Soon Koo Baik, Sang Ok Kwon
Background/Aims: Non-selective beta blockers (NSBBs) are currently the only accepted regimen for preventing portal hypertension (PHT)-related complications. However, the effect of NSBBs is insufficient in many cases. Bacterial translocation (BT) is one of the aggravating factors of PHT in cirrhosis; therefore, selective intestinal decontamination by rifaximin is a possible therapeutic option for improving PHT. We investigated whether the addition of rifaximin to propranolol therapy can improve hepatic venous pressure gradient (HVPG) response...
June 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28646809/efficacy-of-fascial-distortion-model-treatment-for-acute-nonspecific-low-back-pain-in-primary-care-a-prospective-controlled-trial
#6
Detlef Richter, Matthias Karst, Hartmut Buhck, Matthias G Fink
Context • Low-back pain (LBP) is a prevalent and potentially crippling condition for which treatment is often unsatisfactory from the perspectives of physicians, patients, and payers. The application of the fascial distortion model (FDM), an integrated concept for the diagnosis and manipulative treatment of musculoskeletal disorders, is conceptually promising for LBP but has not been investigated systematically. Objective • The study intended to provide proof of concept to establish the noninferiority of the FDM treatment as opposed to the therapy recommended by the German National Disease Management Guideline (NDMG) for acute LBP...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646454/the-oswestry-disability-index-confirmatory-factor-analysis-in-a-sample-of-35-263-verifies-a-one-factor-structure-but-practicality-issues-remain
#7
Charles Philip Gabel, Antonio Cuesta-Vargas, Meihua Qian, Rok Vengust, Ulrich Berlemann, Emin Aghayev, Markus Melloh
PURPOSE: To analyze the factor structure of the Oswestry Disability Index (ODI) in a large symptomatic low back pain (LBP) population using exploratory (EFA) and confirmatory factor analysis (CFA). METHODS: Analysis of pooled baseline ODI LBP patient data from the international Spine Tango registry of EUROSPINE, the Spine Society of Europe. The sample, with n = 35,263 (55.2% female; age 15-99, median 59 years), included 76.1% of patients with a degenerative disease, and 23...
June 23, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28645884/investigation-of-the-effects-of-lycium-barbarum-polysaccharides-against-cadmium-induced-damage-in-testis
#8
Maria Vittoria Varoni, Sergio Domenico Gadau, Valeria Pasciu, Elena Baralla, Elisa Serra, Domenico Palomba, Maria Piera Demontis
This study describes the effects of Lycium barbarum polysaccharides (LBP) on testicular damage induced by cadmium (Cd). Adult male rats were i.p. injected with CdCl2 (4mg/Kg, once) with or without LBP pretreatment (300mg/Kg orally, once a day, for 30days). Testis weight, morphological/histological structure and oxidative stress parameters were evaluated. Several adverse effects were observed after CdCl2 injection, with a significant decrease in body/testis weight ratio (P<0.05), gross morphological changes with hyperemia of the parenchyma, increased volume and alteration in the structure of the seminiferous tubules...
June 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28645867/psychophysical-and-electrophysiological-evidence-for-enhanced-pain-facilitation-and-unaltered-pain-inhibition-in-acute-low-back-pain-patients
#9
Pascal Henri Vuilleumier, Federico Gabriel Arguissain, José Alberto Biurrun Manresa, Alban Ymer Neziri, Arto Christian Nirkko, Ole Kæseler Andersen, Lars Arendt-Nielsen, Michele Curatolo
The aim of this case-control study was to examine differences in neural correlates of pain facilitatory and inhibitory mechanisms between acute low back pain patients and healthy individuals. Pressure pain tolerance (PPT), electrical pain detection thresholds (EDT), pain ratings to repetitive suprathreshold electrical stimulation (SES) and conditioned pain modulation (CPM) were assessed in 18 patients with acute low back pain (LBP) and 18 healthy controls (CTRL). Furthermore, event-related potentials (ERPs) in response to repetitive SES were obtained from high-density electroencephalography...
June 20, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28645861/protective-effect-of-lycium-barbarum-polysaccharides-on-dextromethorphan-induced-mood-impairment-and-neurogenesis-suppression
#10
Kevin Kai-Ting Po, Joseph Wai-Hin Leung, Jackie Ngai-Man Chan, Timothy Kai-Hang Fung, Dalinda Isabel Sánchez-Vidaña, Emily Lok-Lam Sin, Kwok-Fai So, Benson Wui-Man Lau, Andrew Man-Hong Siu
Dextromethorphan (DXM) is one of the common drugs abused by adolescents. It is the active ingredient found in cough medicine which is used for suppressing cough. High dosage of DXM can induce euphoria, dissociative effects and even hallucinations. Chronic use of DXM may also lead to depressive-related symptoms. Lycium barbarum, commonly known as wolfberry, has been used as a traditional Chinese medicine for the treatment of ageing-related neurodegenerative diseases. A recent study has shown the potential beneficial effect of Lycium barbarum to reduce depression-like behavior...
June 20, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28645455/kinematic-chain-reactions-on-trunk-and-dynamic-postural-steadiness-in-subjects-with-recurrent-low-back-pain
#11
Paul S Sung, Michael J Maxwell
Although subjects with recurrent low back pain (LBP) demonstrate altered trunk control, the kinematic and kinetic responses of the trunk have not been carefully investigated. This study was conducted to compare the standing time, spine range of motion (ROM), and dynamic postural steadiness index (DPSI) based on visual condition between subjects with and without recurrent LBP during upright one leg standing. Sixty-three individuals participated in the study, including 34 control subjects and 29 subjects with recurrent LBP...
June 8, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28645291/the-effect-of-zoledronic-acid-on-type-and-volume-of-modic-changes-among-patients-with-low-back-pain
#12
Katri Koivisto, Jyri Järvinen, Jaro Karppinen, Marianne Haapea, Markus Paananen, Eero Kyllönen, Osmo Tervonen, Jaakko Niinimäki
BACKGROUND: Modic changes (MC) are associated with low back pain (LBP). In this study, we compared changes in size and type of MC, after a single intravenous infusion of 5 mg zoledronic acid (ZA) or placebo, among chronic LBP patients with MC on magnetic resonance imaging (MRI), and evaluated whether the MRI changes correlate with symptoms. METHODS: All patients (N = 19 in ZA, 20 in placebo) had MRI at baseline (0.23-1.5 T) and at one year (1.5-3 T). We evaluated the level, type and volume of all the MC...
June 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28644196/cebranopadol-a-novel-first-in-class-analgesic-drug-candidate-first-experience-in-patients-with-chronic-low-back-pain-in-a-randomized-clinical-trial
#13
Annette Christoph, Marie-Henriette Eerdekens, Maurits Kok, Gisela Volkers, Rainer Freynhagen
Chronic low back pain (LBP) is a common condition, usually with involvement of nociceptive and neuropathic pain components, high economic burden and impact on quality of life. Cebranopadol is a potent, first-in-class drug candidate with a novel mechanistic approach, combining nociceptin/orphanin FQ peptide and opioid peptide receptor agonism. We conducted the first Phase II, randomized, doubleblind, placebo- and active-controlled trial, evaluating the analgesic efficacy, safety, and tolerability of cebranopadol in patients with moderate to severe chronic LBP with and without neuropathic pain component...
June 21, 2017: Pain
https://www.readbyqxmd.com/read/28639551/facet-joint-injections-for-people-with-persistent-non-specific-low-back-pain-facet-injection-study-a-feasibility-study-for-a-randomised-controlled-trial
#14
David R Ellard, Martin Underwood, Felix Achana, James Hl Antrobus, Shyam Balasubramanian, Sally Brown, Melinda Cairns, James Griffin, Frances Griffiths, Kirstie Haywood, Charles Hutchinson, Ranjit Lall, Stavros Petrou, Nigel Stallard, Colin Tysall, David A Walsh, Harbinder Sandhu
BACKGROUND: The National Institute for Health and Care Excellence (NICE) 2009 guidelines for persistent low back pain (LBP) do not recommend the injection of therapeutic substances into the back as a treatment for LBP because of the absence of evidence for their effectiveness. This feasibility study aimed to provide a stable platform that could be used to evaluate a randomised controlled trial (RCT) on the clinical effectiveness and cost-effectiveness of intra-articular facet joint injections (FJIs) when added to normal care...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28637603/reliability-and-validity-of-two-multidimensional-self-reported-physical-activity-questionnaires-in-people-with-chronic-low-back-pain
#15
Flávia A Carvalho, Priscila K Morelhão, Marcia R Franco, Chris G Maher, Rob J E M Smeets, Crystian B Oliveira, Ismael F Freitas Júnior, Rafael Z Pinto
BACKGROUND: Although there is some evidence for reliability and validity of self-report physical activity (PA) questionnaires in the general adult population, it is unclear whether we can assume similar measurement properties in people with chronic low back pain (LBP). OBJECTIVE: To determine the test-retest reliability of the International Physical Activity Questionnaire (IPAQ) long-version and the Baecke Physical Activity Questionnaire (BPAQ) and their criterion-related validity against data derived from accelerometers in patients with chronic LBP...
February 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28637597/effects-of-lower-body-quadrant-neural-mobilization-in-healthy-and-low-back-pain-populations-a-systematic-review-and-meta-analysis
#16
REVIEW
Tiago Neto, Sandro R Freitas, Marta Marques, Luis Gomes, Ricardo Andrade, Raúl Oliveira
BACKGROUND: Neural mobilization (NM) is widely used to assess and treat several neuromuscular disorders. However, information regarding the NM effects targeting the lower body quadrant is scarce. OBJECTIVES: To determine the effects of NM techniques targeting the lower body quadrant in healthy and low back pain (LBP) populations. DESIGN: Systematic review with meta-analysis. METHOD: Randomized controlled trials were included if any form of NM was applied to the lower body quadrant...
February 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28636878/lycium-barbarum-polysaccharide-alleviates-nonylphenol-exposure-induced-testicular-injury-in-juvenile-zebrafish
#17
Ze-Yong Tang, Dong Sun, Chun-Wei Qian, Qi Chen, Shun-Shan Duan, Sheng-Yun Sun
Nonylphenol is an endocrine disrupting chemicals that can disrupt the organisms' reproductive system, and exists widely in rivers and lakes. Lycium barbarum polysaccharide (LBP) is the main active constituent (about 10%) in Lycium barbarum, which is used to protect reproductive health. In this study, we investigated whether LBP can alleviate nonylphenol exposure induced testicular injury in juvenile zebrafish. We detected histological alteration, anti-oxidant enzyme profile and P450 gene transcription to assess LBP effect on testicular development...
June 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28635877/-a-neuropathic-component-of-lumboischialgia-mechanisms-of-development-and-treatment-approaches
#18
M V Churyukanov, G E Shevtsova, O I Zagorulko
Low back pain (LBP) is accompanied by the development of pain syndrome that spreads into the leg in 25-57% of patients. This is an important factor predicting the risk of transition of pain from acute to chronic and is an indirect indicator of disease severity. It is often impossible to specify the primary mechanism facilitated pain irradiation in lumboischialgia because many structures can cause analogous symptoms. Mechanisms of development of LBP are represented by nociceptive, neuropathic and psychogenic components...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28634547/kinesiophobia-pain-muscle-functions-and-functional-performances-among-older-persons-with-low-back-pain
#19
Nor Azizah Ishak, Zarina Zahari, Maria Justine
OBJECTIVES: This study aims (1) to determine the association between kinesiophobia and pain, muscle functions, and functional performances and (2) to determine whether kinesiophobia predicts pain, muscle functions, and functional performance among older persons with low back pain (LBP). METHODS: This is a correlational study, involving 63 institutionalized older persons (age = 70.98 ± 7.90 years) diagnosed with LBP. Anthropometric characteristics (BMI) and functional performances (lower limb function, balance and mobility, and hand grip strength) were measured...
2017: Pain Research and Treatment
https://www.readbyqxmd.com/read/28634422/lipopolysaccharide-binding-protein-downregulates-fractalkine-through-activation-of-p38-mapk-and-nf-%C3%AE%C2%BAb
#20
Xia Huang, Yi Zeng, Yujie Jiang, Yueqiu Qin, Weigui Luo, Shulin Xiang, Suren R Sooranna, Liao Pinhu
BACKGROUND: LBP and fractalkine are known to be involved in the pathogenesis of ARDS. This study investigated the relationship between LBP and fractalkine in LPS-induced A549 cells and rat lung tissue in an ARDS rat model. METHODS: A549 cells were transfected with LBP or LBP shRNA plasmid DNA or pretreated with SB203580 or SC-514 following LPS treatment. An ARDS rat model was established using LPS with or without LBPK95A, SB203580, or SC-514 treatment. RT-PCR, western blotting, ELISA, immunofluorescence, coimmunoprecipitation, and immunohistochemical staining were used to study the expression of fractalkine and LBP and p38 MAPK and p65 NF-κB activities...
2017: Mediators of Inflammation
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