Neslihan Günay, İsmail Dursun, İbrahim Gökçe, Mehtap Akbalık Kara, Demet Tekcan, Neslihan Çiçek, Meral Torun Bayram, Mustafa Koyun, Nida Dinçel, Hasan Dursun, Seha Saygılı, Zeynep Nagehan Yürük Yıldırım, Selçuk Yüksel, Osman Dönmez, Sibel Yel, Beltinge Demircioğlu Kılıç, Özlem Aydoğ, Bahriye Atmış, Aysun Çaltık Yılmaz, Sevcan A Bakkaloğlu, Mehmet Baha Aytaç, Mehmet Taşdemir, Belde Kasap Demir, Alper Soylu, Elif Çomak, Aslı Kantar Özşahin, Alper Kaçar, Nur Canpolat, Alev Yılmaz, İlknur Girişgen, Kadirye Betül Akkoyunlu, Harika Alpay, Hakan M Poyrazoğlu
BACKGROUND: C3 glomerulopathy (C3G) is a complement-mediated disease. Although genetic studies are not required for diagnosis, they are valuable for treatment planning and prognosis prediction. The aim of this study is to investigate the clinical phenotypes, kidney survival, and response to mycophenolate mofetil (MMF) treatment in pediatric C3G patients with and without mutations in complement-related genes. METHODS: Sixty pediatric C3G patients were included, divided into two groups based on complement-related gene mutations...
December 2, 2023: Pediatric Nephrology