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https://www.readbyqxmd.com/read/29147891/long-term-presence-of-angiotensin-ii-type-1-receptor-autoantibody-reduces-aldosterone-production-by-triggering-ca-2-overload-in-h295r-cells
#1
Jinghui Lei, Suli Zhang, Pengli Wang, Yang Liao, Jingwei Bian, Xiaochen Yin, Ye Wu, Lina Bai, Feng Wang, Xiaoli Yang, Huirong Liu
Preeclamptic women are reported to have inadequate plasma volume expansion coupled with a suppressed secretion of aldosterone; however, the specific mechanism of preeclampsia remains unclear. We demonstrated that the presence of long-term angiotensin II type 1 receptor autoantibody (AT1-AA) reduces aldosterone production by triggering a Ca(2+) overload in H295R cells. AT1-AA was discovered in preeclamptic women and reported to activate AT1R, and consequently elevate intracellular Ca(2+). We found that AT1-AA significantly prolonged the time of intracellular Ca(2+) elevation...
November 16, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29138903/next-generation-sequencing-to-identify-candidate-genes-and-develop-diagnostic-markers-for-a-novel-phytophthora-resistance-gene-rpshc18-in-soybean
#2
Chao Zhong, Suli Sun, Yinping Li, Canxing Duan, Zhendong Zhu
A novel Phytophthora sojae resistance gene RpsHC18 was identified and finely mapped on soybean chromosome 3. Two NBS-LRR candidate genes were identified and two diagnostic markers of RpsHC18 were developed. Phytophthora root rot caused by Phytophthora sojae is a destructive disease of soybean. The most effective disease-control strategy is to deploy resistant cultivars carrying Phytophthora-resistant Rps genes. The soybean cultivar Huachun 18 has a broad and distinct resistance spectrum to 12 P. sojae isolates...
November 14, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29122670/infection-of-neuroblastoma-cells-by-rabies-virus-is-modulated-by-the-virus-titer
#3
Natalia Langenfeld Fuoco, Sandriana Dos Ramos Silva, Elaine Raniero Fernandes, Fernanda Guedes Luiz, Orlando Garcia Ribeiro, Iana Suly Santos Katz
Rabies is a lethal viral infection that can affect almost all mammals, including humans. To better understand the replication of Rabies lyssavirus, we investigated if the viral load in brains naturally infected with rabies influences viral internalization and viral growth kinetics in neuroblastoma cells, and if the viral load affects mortality in mice after intradermal infection. We noted that high initial viral loads in brains (group II) were unfavourable for increasing viral titers during serial passages in neuroblastoma cells when compared to low initial viral loads in brains (group I)...
November 6, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29119995/fabrication-of-tough-photonic-crystal-patterns-with-vivid-structural-colors-by-direct-handwriting
#4
Xin Su, Yu Jiang, Xiaoqian Sun, Suli Wu, Bingtao Tang, Wenbin Niu, Shufen Zhang
Patterned photonic crystals (PCs) have attracted considerable attention due to their great potential in practical applications. Direct writing is an important and convenient method to fabricate patterned PCs. However, due to the limited interaction among spheres and the evaporation of ink, the obtained patterns usually suffer from poor structure strength, and non-uniform and unstable structural colors. In this work, an in situ embedding and locking strategy for fabricating tough PC patterns in one step was demonstrated...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29095822/adherence-to-clinical-practice-guidelines-cpg-management-of-dengue-infection-in-adults-revised-2nd-edition
#5
Marzilawati Abd Rahman, Rafdzah Ahmad Zaki, Roza Sarimin, Mohd Izhar Ariff, Zailiza Suli, Maimunah Mahmud, Ker Hong Bee, Cecilia Anthonysamy, Azahirafairud Abdul Rahim, Balvinder Singh Gill, Shanti Rudra Deva, Ana Fizalinda Abdullah Sani, Erni Zurina Romli, Izzuna Mudla Mohamed Ghazali, Mohd Aminuddin Mohd Yusof, Nafisah Ahmad Lutfi, Shahril Effendi Shuib, Noormah Mohd Darus, Rugayah Bakri, 'Abqariyah Yahya
The Malaysian Dengue Clinical Practice Guidelines (CPG) have been developed to provide evidence-based guidance in the management of dengue infections. The use of these guidelines is essential to ensure its recommendations are being practiced. However, the adherence to the guidelines for management of dengue (revised 2nd edition) by healthcare providers still remains unknown. Therefore, the aim of this study was to evaluate the proportion among healthcare providers that adhere to this Dengue CPG. A retrospective cohort study of dengue cases registered from 1 January 2014 to 1 June 2015 was conducted in public hospitals and health clinics in Selangor, Putrajaya and Kuala Lumpur...
2017: PloS One
https://www.readbyqxmd.com/read/29068350/chromium-removal-capability-and-photosynthetic-characteristics-of-cyperus-alternifolius-and-coix-lacryma-jobi-l-in-vertical-flow-constructed-wetland-treated-with-hexavalent-chromium-bearing-domestic-sewage
#6
Suli Li, Hailian Huang, Zhigang Li, Zhengwen Li, Zhenli He, He Liang
In this study, the chromium removal capability and photosynthetic capacity response of plants were investigated in vertical flow wetland microcosms (VFWM) treated with Cr(VI) bearing domestic sewage. Two plants, Cyperus alternifolius (C. alternifolius) and Coix lacryma-jobi L. (C. lacryma-jobi L.) grown in the VFWM enhanced the purification of Cr(VI) enriched domestic sewage. Cr concentration in the effluent fell below detection limit (<0.03 mg L(-1)), except for the C. alternifolius wetland treated with 40 mg L(-1) Cr(VI)...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29063863/controlled-preparation-of-m-ag-au-tio2-through-sulfydryl-assisted-method-for-enhanced-photocatalysis
#7
Hongbo Xia, Suli Wu, Jiajie Bi, Shufen Zhang
Here a simple and effective method was explored to fabricate M/TiO2 (M = Ag, Au) composites, which required neither pre-treatment of TiO2 nor any additives as reducing agent. Using amorphous TiO2 spheres functionalized with SH groups as starting materials, the noble metallic ions (Ag, Au) can be adsorbed by TiO2 due to their special affinity with SH groups, which is beneficial to the uniform dispersion of metallic ions on the surface of TiO2. Then the adsorbed ions were reduced to form noble metal nanoparticles by heating process (95 °C) directly without additive as reduction agent...
October 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29046858/fabrication-of-poly-styrene-co-maleic-anhydride-ag-spheres-with-high-surface-charge-intensity-and-their-self-assembly-into-photonic-crystal-films
#8
Jiajie Bi, Genrui Fan, Suli Wu, Xin Su, Hongbo Xia, Shu-Fen Zhang
Herein, we developed a method to prepare monodisperse poly(styrene-co-maleic anhydride)@Ag (PSMA@Ag) core-shell microspheres with high surface charge intensity by using an in situ reduction method. In this method, ethylenediamine tetraacetic acid tetrasodium salt (Na4EDTA) was used as a reducing agent to promote the growth of Ag, and at the same time endowed the PSMA@Ag spheres with a surface charge. The monodispersity of PSMA and PSMA@Ag and the ordered array of the photonic crystal films were characterized by using SEM...
October 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28985615/body-temperature-and-motion-evaluation-of-an-online-monitoring-system-in-pigs-challenged-with-porcine-reproductive-respiratory-syndrome-virus
#9
Tamás Süli, Máté Halas, Zsófia Benyeda, Réka Boda, Sándor Belák, Marta Martínez-Avilés, Eduardo Fernández-Carrión, José Manuel Sánchez-Vizcaíno
Highly contagious and emerging diseases cause significant losses in the pig producing industry worldwide. Rapid and exact acquisition of real-time data, like body temperature and animal movement from the production facilities would enable early disease detection and facilitate adequate response. In this study, carried out within the European Union research project RAPIDIA FIELD, we tested an online monitoring system on pigs experimentally infected with the East European subtype 3 Porcine Reproductive & Respiratory Syndrome Virus (PRRSV) strain Lena...
September 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28973889/simultaneous-two-photon-imaging-of-intracellular-chloride-concentration-and-ph-in-mouse-pyramidal-neurons-in-vivo
#10
Sebastian Sulis Sato, Pietro Artoni, Silvia Landi, Olga Cozzolino, Riccardo Parra, Enrico Pracucci, Francesco Trovato, Joanna Szczurkowska, Stefano Luin, Daniele Arosio, Fabio Beltram, Laura Cancedda, Kai Kaila, Gian Michele Ratto
Intracellular chloride ([Cl(-)]i) and pH (pHi) are fundamental regulators of neuronal excitability. They exert wide-ranging effects on synaptic signaling and plasticity and on development and disorders of the brain. The ideal technique to elucidate the underlying ionic mechanisms is quantitative and combined two-photon imaging of [Cl(-)]i and pHi, but this has never been performed at the cellular level in vivo. Here, by using a genetically encoded fluorescent sensor that includes a spectroscopic reference (an element insensitive to Cl(-) and pH), we show that ratiometric imaging is strongly affected by the optical properties of the brain...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28946875/overexpression-of-lncrna-igfbp4-1-reprograms-energy-metabolism-to-promote-lung-cancer-progression
#11
Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li, Lei Yang, Yunchao Huang, Jiachun Lu
BACKGROUND: Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served as key regulators implicated in tumor development and progression by promoting proliferation, invasion and metastasis. However, the associations of lncRNAs with cellular energy metabolism in lung cancer (LC) need to be clarified. METHODS: Here, we conducted bioinformatics analysis and found insulin-like growth factor binding protein 4-1 (IGFBP4-1) as a new candidate lncRNA located in the upstream region of IGFBP4 gene...
September 25, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28942256/antibiotics-in-the-agricultural-soils-from-the-yangtze-river-delta-china
#12
Jianteng Sun, Qingtao Zeng, Daniel C W Tsang, L Z Zhu, X D Li
This study focused on the occurrence and spatial distribution of 13 common antibiotics in the agricultural soils of the Yangtze River Delta (YRD), China. Antibiotics were detected in all the 241 soil samples (i.e., 100% detection rate) with the total concentrations ranging from 4.55 to 2,010 ng/g dry weight. The concentrations of three antibiotic classes decreased in the order: quinolones (mean 48.8 ng/g) > tetracyclines (mean 34.9 ng/g) > sulfonamides (mean 2.35 ng/g). Ciprofloxacin was the prevalent compound with a mean concentration of 27...
September 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28929113/impact-of-fish-oil-supplementation-and-interruption-of-fructose-ingestion-on-glucose-and-lipid-homeostasis-of-rats-drinking-different-concentrations-of-fructose
#13
Paola M Sulis, Katia Motta, Amanda M Barbosa, Matheus H Besen, Julia S da Silva, Everson A Nunes, Alex Rafacho
Background. Continuous fructose consumption may cause elevation of circulating triacylglycerol. However, how much of this alteration is reverted after the removal of fructose intake is not known. We explored this question and compared the efficacy of this approach with fish oil supplementation. Methods. Male Wistar rats were divided into the following groups: control (C), fructose (F) (water intake with 10% or 30% fructose for 9 weeks), fish oil (FO), and fructose/fish oil (FFO). Fish oil was supplemented only for the last 33 days of fructose ingestion...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28925370/controlled-preparation-of-m-ag-au-tio-sub-2-sub-through-sulfydryl-assisted-method-for-enhanced-photocatalysis
#14
Hongbo Xia, Suli Wu, Jiajie Bi, Shufen Zhang
Here a simple and effective method was explored to fabricate M/TiO<sub>2</sub> (M=Ag, Au) composites, which required neither pre-treatment of TiO<sub>2</sub> nor any additives as reducing agent. Using amorphous TiO<sub>2</sub> spheres functionalized with SH groups as starting materials, the noble metallic ions (Ag, Au) can be adsorbed by TiO<sub>2</sub> due to their special affinity with SH groups, which is beneficial to the uniform dispersion of metallic ions on the surface of TiO<sub>2</sub>...
September 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28923155/modeling-stochastic-complexity-in-complex-adaptive-systems-non-kolmogorov-probability-and-the-process-algebra-approach
#15
William H Sulis
Walter Freeman III pioneered the application of nonlinear dynamical systems theories and methodologies in his work on mesoscopic brain dynamics.Sadly, mainstream psychology and psychiatry still cling to linear correlation based data analysis techniques, which threaten to subvert the process of experimentation and theory building. In order to progress, it is necessary to develop tools capable of managing the stochastic complexity of complex biopsychosocial systems, which includes multilevel feedback relationships, nonlinear interactions, chaotic dynamics and adaptability...
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28923153/introduction-walter-j-freeman-iii-january-30-1927-april-24-2016
#16
William H Sulis, Irina Trofimova
No abstract text is available yet for this article.
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28902004/antiretroviral-therapy-in-hiv-infected-children-with-tuberculosis-a-systematic-review
#17
Giorgia Sulis, Silvia Amadasi, Anna Odone, Martina Penazzato, Alberto Matteelli
BACKGROUND: Tuberculosis is the major cause of mortality in HIV-infected children globally. Current guidelines about the management of antiretroviral therapy in children with tuberculosis are based on a limited number of non-randomized studies involving small numbers of participants. The aim of the study was to systematically retrieve and critically appraise available evidence on the efficacy and safety of different antiretroviral regimens in children with HIV infection who are receiving treatment for active tuberculosis...
September 7, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28886881/pahs-accelerate-the-propagation-of-antibiotic-resistance-genes-in-coastal-water-microbial-community
#18
Jing Wang, Jing Wang, Zelong Zhao, Jingwen Chen, Hong Lu, Guangfei Liu, Jiti Zhou, Xiaoyan Guan
Antibiotic resistance genes (ARGs) have been regarded as emerging contaminants and have attracted growing attention owing to their widespread presence in the environment. In addition to the well-documented selective pressure of antibiotics, ARGs have also become prevalent because of anthropogenic impacts. Coastal habitats are located between terrestrial and marine ecosystems, which are a hotspot for anthropogenic impacts. Excessive accumulation of polycyclic aromatic hydrocarbons (PAHs) has posed a serious threat to coastal habitats, but no information is available on the effect of PAHs on antibiotic resistance in the microbial community of coastal environments...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28866406/rapid-startup-of-thermophilic-anaerobic-digester-to-remove-tetracycline-and-sulfonamides-resistance-genes-from-sewage-sludge
#19
Rui Xu, Zhao-Hui Yang, Qing-Peng Wang, Yang Bai, Jian-Bo Liu, Yue Zheng, Yan-Ru Zhang, Wei-Ping Xiong, Kito Ahmad, Chang-Zheng Fan
Spread of antibiotic resistance genes (ARGs) originating from sewage sludge is highlighted as an eminent health threat. This study established a thermophilic anaerobic digester using one-step startup strategy to quickly remove tetracycline and sulfonamides resistance genes from sewage sludge. At least 20days were saved in the startup period from mesophilic to thermophilic condition. Based on the results of 16S rDNA amplicons sequencing and predicted metagenomic method, the successful startup largely relied on the fast colonization of core thermophilic microbial population (e...
January 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28860086/assessing-the-impact-of-charge-variants-on-stability-and-viscosity-of-a-high-concentration-antibody-formulation
#20
Shantanu V Sule, Jason E Fernandez, Vincent J Mecozzi, Yana Kravets, William C Yang, Pamela Feng, Suli Liu, Li Zang, Allan D Capili, Tia B Estey, Kapil Gupta
Characterizing molecular charge variants or isoforms is essential for understanding safety, potency, and bioavailability of antibody therapeutics. However, there is little information on how they influence stability and viscosity-properties governing immunogenicity and delivery. To bridge this gap, we studied antibody stability as a function of charge variant content generated via bioreactor process. We were able to systematically vary acidic variant levels as a function of bioreactor harvest time. Importantly, we do not observe any impact on aggregation behavior of a formulated antibody at high protein concentration as a function of acidic variant level...
August 30, 2017: Journal of Pharmaceutical Sciences
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