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M L Sulis, T M Blonquist, K E Stevenson, S K Hunt, S Kay-Green, U H Athale, L A Clavell, P D Cole, K M Kelly, C Laverdiere, J M Leclerc, B Michon, M A Schorin, J G Welch, D S Neuberg, S E Sallan, L B Silverman
BACKGROUND: Pediatric patients receiving induction chemotherapy for newly diagnosed acute lymphoblastic leukemia (ALL) are at high risk of developing life-threatening infections. We investigated whether uniform antibacterial guidelines, including mandatory antibacterial prophylaxis in afebrile patients during induction, decreases the incidence of microbiologically documented bacteremia. METHODS: Between 2012 and 2015, 230 patients with newly diagnosed ALL (aged 1-21) were enrolled on Dana-Farber Cancer Institute ALL Consortium Protocol 11-001 (DFCI 11-001)...
January 10, 2018: Pediatric Blood & Cancer
Jiangdong Qiu, Gang Yang, Mengyu Feng, Suli Zheng, Zhe Cao, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms, early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to pancreatic cancer progression require further exploration. Based on accumulating evidence, extracellular vesicles, including exosomes and microvesicles, play a crucial role in pancreatic cancer progression and chemoresistance. Furthermore, they also possess the potential to be promising biomarkers, therapy targets and tools for treating pancreatic cancer...
January 5, 2018: Molecular Cancer
Yan Zhang, Suli Tian, Xiaodong Li, Yanchao Ji, Zhongcheng Wang, Chang Liu
We aimed to characterize the expression pattern of UBE2C in rectal carcinoma and elucidate its fundamental involvement in rectal carcinoma biology. The relative expression of UBE2C in rectal carcinoma was determined by immunoblotting and QPCR. The cell viability was measured using CCK-8 assay. The anchorage-independent growth was evaluated with soft agar assay. Cell apoptosis was detected by Annexin V-PI staining. Invasion capacity was determined by transwell chamber. Tumor growth was monitored in xenograft mice model...
January 5, 2018: Cancer Biology & Therapy
Anna Camilla Birkegård, Tariq Halasa, Anders Folkesson, Julie Clasen, Kaare Græsbøll, Nils Toft
Antimicrobial resistance in pigs has been under scrutiny for many years. However, many questions remain unanswered, including whether the initial antimicrobial resistance level of a pig will influence the antimicrobial resistance found at slaughter. Faecal samples from finishers pigs from 681 farms and from sows from 82 farms were collected, and levels of seven antimicrobial resistance genes, ermB, ermF, sulI, sulII, tet(M), tet(O), and tet(W), were quantified by high-capacity qPCR. There were 40 pairs of observations where the finishers were born in the farms of the sows...
January 1, 2018: Preventive Veterinary Medicine
Jianlin He, Wenfei Huang, Shizhong Zheng, Michael Vigorito, Sulie L Chang
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients receiving combination anti-retroviral therapy (cART). Docosahexaenoic acid (DHA) is a marine compound that modulates inflammatory responses. Using HIV-1Tg rats subjected to binge exposure to ethanol (EtOH), this study examined whether DHA could reduce the detrimental neurological effects of EtOH and HIV proteins...
December 19, 2017: Journal of Neurovirology
Fulai Qi, Zhangxun Xia, Jutao Jin, Xudong Fu, Wei Wei, Suli Wang, Gongquan Sun
Due to the unique structure, carbon aerogels have always shown great potential for multifunctional applications. At present, it is highly desirable but remains challenging to tailor the micro-structures in respect of porosity and specific surface area to further expand its significance. A facile chemical foaming coupled self-etching strategy is developed for multiscale processing of carbon aerogels. The strategy is directly realized via the pyrolysis of a multifunctional precursor (pentaerythritol melamine phosphate) without any special drying process and multiple steps...
December 11, 2017: ACS Applied Materials & Interfaces
Yijing Zhu, Yayi Wang, Shuai Zhou, Xuxin Jiang, Xiao Ma, Chao Liu
Antibiotic resistance genes (ARGs) are an emerging concern in wastewater treatment plants (WWTPs), as dissemination of ARGs can pose a serious risk to human health. Few studies, however, have quantified ARGs in membrane bioreactors (MBRs), although MBRs have been widely used for both municipal and industrial wastewater treatment. To reveal the capacity of MBRs for removal of ARGs and the response of membrane fouling after antibiotic exposure, five typical ARG subtypes (sulI, sulII, tetC, tetX and ereA) and int1 were quantified affiliated by systematic membrane foulants analysis in a laboratory-scale anoxic/aerobic membrane bioreactor (A/O-MBR)...
November 30, 2017: Water Research
Izabele Vian, Paulo Zielinsky, Ana Maria Zílio, Maximiliano I Schaun, Camila Brum, Kenya Venusa Lampert, Nataly De Ávila, Giovana Baldissera, Tamires Mezzomo Klanovicz, Karina Zenki, Jesus Zurita-Peralta, Alessandro Olszewski, Antonio Piccoli, Luiz Henrique Nicoloso, Natássia Sulis, Luiza Van Der Sand, Melissa Markoski
OBJECTIVE: Anti-inflammatory substances that inhibit the synthesis of prostaglandins, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and polyphenol-rich foods, can cause constriction of the fetal ductus arteriosus. This study aimed to test the hypothesis that reversal of fetal ductal constriction after maternal restriction of polyphenol-rich foods, in the third trimester of pregnancy, is accompanied by increased prostaglandin E2(PGE2) plasma levels. METHOD: A controlled clinical trial was designed...
December 5, 2017: Ultrasound in Obstetrics & Gynecology
Hongna Li, Binxu Li, Zhiguo Zhang, Changxiong Zhu, Yunlong Tian, Jing Ye
The evolution of microbial communities during the electrokinetic treatment of antibiotic-polluted soil (EKA) was investigated with chlortetracycline (CTC), oxytetracycline (OTC) and tetracycline (TC) as template antibiotics. The total population of soil microorganisms was less affected during the electrokinetic process, while living anti-CTC, anti-OTC, anti-TC and anti-MIX bacteria were inactivated by 10.48%, 31.37%, 34.76%, and 22.08%, respectively, during the 7-day treatment compared with antibiotic-polluted soil without an electric field (NOE)...
November 30, 2017: Ecotoxicology and Environmental Safety
Deepa Bhojwani, Michael J Burke, Terzah Horton, David S Ziegler, Maria Luisa Sulis, Kirk R Schultz, Alan Wayne, Shai Izraeli, Bill H Chang
During the 2016 Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium investigators' meeting (Los Angeles, CA), a Biology Working Group was established to support the consortium's mission of developing innovative therapies for currently incurable childhood leukemias and lymphomas. The charge of the Biology Working Group was to address how TACL could advance biological investigations of pediatric relapsed/refractory hematologic malignancies while undertaking forward-looking therapeutic trials...
November 30, 2017: Pediatric Hematology and Oncology
Suli Liu, Qinpu Liu, Yun Lv, Biyao Chen, Quan Zhou, Lei Wang, Qiuhui Zheng, Chenjing Che, Changyun Chen
The construction of a high efficiency and stable catalyst for use in electrochemical hydrogen generation has great significance for renewable energy technologies. Herein, we show for the first time that Ru decorated with NiCoP is an excellent hydrogen evolving catalyst in both acidic and alkaline conditions, close in performance to that of Pt/C.
November 27, 2017: Chemical Communications: Chem Comm
Hafizah Y Chenia, Anelet Jacobs
Antibacterial compounds and metals co-select for antimicrobial resistance when bacteria harbour resistance genes towards both types of compounds, facilitating the proliferation and evolution of antimicrobial and heavy metal resistance. Antimicrobial and heavy metal resistance indices of 42 Gram-negative bacteria from a tilapia aquaculture system were determined to identify possible correlations between these phenotypes. Agar dilution assays were carried out to determine susceptibility to cadmium, copper, lead, mercury, chromate and zinc, while susceptibility to 21 antimicrobial agents was investigated by disk diffusion assays...
November 21, 2017: Diseases of Aquatic Organisms
Jinghui Lei, Suli Zhang, Pengli Wang, Yang Liao, Jingwei Bian, Xiaochen Yin, Ye Wu, Lina Bai, Feng Wang, Xiaoli Yang, Huirong Liu
Preeclamptic women are reported to have inadequate plasma volume expansion coupled with a suppressed secretion of aldosterone; however, the specific mechanism of preeclampsia remains unclear. We demonstrated that the presence of long-term angiotensin II type 1 receptor autoantibody (AT1-AA) reduces aldosterone production by triggering a Ca(2+) overload in H295R cells. AT1-AA was discovered in preeclamptic women and reported to activate AT1R, and consequently elevate intracellular Ca(2+). We found that AT1-AA significantly prolonged the time of intracellular Ca(2+) elevation...
November 16, 2017: Immunologic Research
Chao Zhong, Suli Sun, Yinping Li, Canxing Duan, Zhendong Zhu
A novel Phytophthora sojae resistance gene RpsHC18 was identified and finely mapped on soybean chromosome 3. Two NBS-LRR candidate genes were identified and two diagnostic markers of RpsHC18 were developed. Phytophthora root rot caused by Phytophthora sojae is a destructive disease of soybean. The most effective disease-control strategy is to deploy resistant cultivars carrying Phytophthora-resistant Rps genes. The soybean cultivar Huachun 18 has a broad and distinct resistance spectrum to 12 P. sojae isolates...
November 14, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Natalia Langenfeld Fuoco, Sandriana Dos Ramos Silva, Elaine Raniero Fernandes, Fernanda Guedes Luiz, Orlando Garcia Ribeiro, Iana Suly Santos Katz
Rabies is a lethal viral infection that can affect almost all mammals, including humans. To better understand the replication of Rabies lyssavirus, we investigated if the viral load in brains naturally infected with rabies influences viral internalization and viral growth kinetics in neuroblastoma cells, and if the viral load affects mortality in mice after intradermal infection. We noted that high initial viral loads in brains (group II) were unfavourable for increasing viral titers during serial passages in neuroblastoma cells when compared to low initial viral loads in brains (group I)...
November 6, 2017: Antiviral Research
Xin Su, Yu Jiang, Xiaoqian Sun, Suli Wu, Bingtao Tang, Wenbin Niu, Shufen Zhang
Patterned photonic crystals (PCs) have attracted considerable attention due to their great potential in practical applications. Direct writing is an important and convenient method to fabricate patterned PCs. However, due to the limited interaction among spheres and the evaporation of ink, the obtained patterns usually suffer from poor structure strength, and non-uniform and unstable structural colors. In this work, an in situ embedding and locking strategy for fabricating tough PC patterns in one step was demonstrated...
November 23, 2017: Nanoscale
Marzilawati Abd Rahman, Rafdzah Ahmad Zaki, Roza Sarimin, Mohd Izhar Ariff, Zailiza Suli, Maimunah Mahmud, Ker Hong Bee, Cecilia Anthonysamy, Azahirafairud Abdul Rahim, Balvinder Singh Gill, Shanti Rudra Deva, Ana Fizalinda Abdullah Sani, Erni Zurina Romli, Izzuna Mudla Mohamed Ghazali, Mohd Aminuddin Mohd Yusof, Nafisah Ahmad Lutfi, Shahril Effendi Shuib, Noormah Mohd Darus, Rugayah Bakri, 'Abqariyah Yahya
The Malaysian Dengue Clinical Practice Guidelines (CPG) have been developed to provide evidence-based guidance in the management of dengue infections. The use of these guidelines is essential to ensure its recommendations are being practiced. However, the adherence to the guidelines for management of dengue (revised 2nd edition) by healthcare providers still remains unknown. Therefore, the aim of this study was to evaluate the proportion among healthcare providers that adhere to this Dengue CPG. A retrospective cohort study of dengue cases registered from 1 January 2014 to 1 June 2015 was conducted in public hospitals and health clinics in Selangor, Putrajaya and Kuala Lumpur...
2017: PloS One
Suli Li, Hailian Huang, Zhigang Li, Zhengwen Li, Zhenli He, He Liang
In this study, the chromium removal capability and photosynthetic capacity response of plants were investigated in vertical flow wetland microcosms (VFWM) treated with Cr(VI) bearing domestic sewage. Two plants, Cyperus alternifolius (C. alternifolius) and Coix lacryma-jobi L. (C. lacryma-jobi L.) grown in the VFWM enhanced the purification of Cr(VI) enriched domestic sewage. Cr concentration in the effluent fell below detection limit (<0.03 mg L(-1)), except for the C. alternifolius wetland treated with 40 mg L(-1) Cr(VI)...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Hongbo Xia, Suli Wu, Jiajie Bi, Shufen Zhang
Here a simple and effective method was explored to fabricate M/TiO2 (M = Ag, Au) composites, which required neither pre-treatment of TiO2 nor any additives as reducing agent. Using amorphous TiO2 spheres functionalized with SH groups as starting materials, the noble metallic ions (Ag, Au) can be adsorbed by TiO2 due to their special affinity with SH groups, which is beneficial to the uniform dispersion of metallic ions on the surface of TiO2. Then the adsorbed ions were reduced to form noble metal nanoparticles by heating process (95 °C) directly without additive as reduction agent...
October 23, 2017: Nanotechnology
Jiajie Bi, Genrui Fan, Suli Wu, Xin Su, Hongbo Xia, Shu-Fen Zhang
Herein, we developed a method to prepare monodisperse poly(styrene-co-maleic anhydride)@Ag (PSMA@Ag) core-shell microspheres with high surface charge intensity by using an in situ reduction method. In this method, ethylenediamine tetraacetic acid tetrasodium salt (Na4EDTA) was used as a reducing agent to promote the growth of Ag, and at the same time endowed the PSMA@Ag spheres with a surface charge. The monodispersity of PSMA and PSMA@Ag and the ordered array of the photonic crystal films were characterized by using SEM...
October 2017: ChemistryOpen
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