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Yanying Guo, Jazyra Zynat, Shuqing Xing, Liang Xin, Suli Li, Nurongguli Mammat, Yuan Chen, Limin Zhao, Hongli Zhao, Xinling Wang
Recent incidence rates for Hashimoto's thyroiditis (HT) and hypothyroidism are higher than those of previous studies. Previous studies indicated that T helper cells may have a major role in the pathogenesis and development of HT, but there is no consensus in the literature. The aim of the present study was to explore the peripheral T helper cell response in the different stages of HT. In this cross-sectional study, we performed flow cytometry analysis to determine the various T cell subsets of 389 patients with HT (34 patients with HT who developed overt hypothyroidism, and 148 patients with HT who developed subclinical hypothyroidism), as well as 51 healthy controls...
April 2018: Experimental and Therapeutic Medicine
Ruru Guo, Yang Tu, Shaowei Xie, Xue Song Liu, Yang Song, Suli Wang, Xiaoxiang Chen, Liangjing Lu
BACKGROUND/AIMS: Neutrophil extracellular traps (NETs) are known to play an important role in systemic lupus erythematosus (SLE) by triggering innate and adaptive immune responses. The molecular mechanisms responsible for their formation in SLE are still unclear. In this study, we aim to characterize the role of the receptor-interacting protein kinase-1 (RIPK1), a homologous serine/threonine kinase previously implicated in the regulation of necroptosis and tissue injury, in decreasing neutrophil death and formation of NETs, and to investigate the clinical implications of RIPK1 in SLE...
March 13, 2018: Cellular Physiology and Biochemistry
Li Wang, Yang Li, Na Ning, Jin Wang, Zi Yan, Suli Zhang, Xiangying Jiao, Xiaohui Wang, Huirong Liu
It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-β1 -adrenergic receptor autoantibodies (β1 -AABs) decreased myocardial autophagy, but the role of decreased autophagy in cardiomyocyte apoptosis remains unclear. In the present study, we used a β1 -AAB-immunized rat model to investigate the role of decreased autophagy in cardiomyocyte apoptosis. We reported that the level of autophagic flux increased early and then decreased in an actively β1 -AAB-immunized rat model...
March 14, 2018: Cell Death & Disease
G Sulis, A C C Carvalho, S Capone, Y Hamada, P F Giorgetti, P da Silva Martins, H Getahun, A Matteelli
BACKGROUND: Although the management of latent tuberculous infection (LTBI) is a core component of the End TB Strategy, there is limited information about the status of implementation of such interventions in most African countries. METHODS: A web-based survey involving the 47 countries of the African Region was conducted between November 2016 and April 2017. RESULTS: The questionnaire was completed by 32/47 (68.1%) National TB Programme managers or their delegates...
February 1, 2018: International Journal of Tuberculosis and Lung Disease
Suli Zhi, Liang Tian, Nan Li, Keqiang Zhang
The MnO2 -mullite-cordierite composite particle (MnO2 -MCP) was prepared and firstly was applied as catalyst with sodium hypochlorite (NaOCl) as oxidant in heterogeneous Fenton-like system for methylene blue (MB) decolorization. The MnO2 -MCP was characterized by XRD, SEM, EDS and BET analysis. The decolorization efficiencies of MB/MnO2 -MCP, MB/NaClO, (MB after filtrating MnO2 -MCP)/NaClO and MB/MnO2 -MCP/NaClO were compared, which confirmed the interaction ability between MnO2 -MCP and NaClO. After evaluating the role of adsorption of MB by MnO2 -MCP, the catalytic oxidation effects of MnO2 -MCP with NaClO on MB were exploited...
March 2, 2018: Journal of Environmental Management
Jana Uher, Irina Trofimova, William Sulis, Petra Netter, Luiz Pessoa, Michael I Posner, Mary K Rothbart, Vladimir Rusalov, Isaac T Peterson, Louis A Schmidt
Throughout the last 2500 years, the classification of individual differences in healthy people and their extreme expressions in mental disorders has remained one of the most difficult challenges in science that affects our ability to explore individuals' functioning, underlying psychobiological processes and pathways of development. To facilitate analyses of the principles required for studying individual differences, this theme issue brought together prominent scholars from diverse backgrounds of which many bring unique combinations of cross-disciplinary experiences and perspectives that help establish connections and promote exchange across disciplines...
April 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
William Sulis
Temperament of healthy people and mental illnesses, particularly affective disorders, have been conjectured to lie along a continuum of neurobehavioural regulation. Understanding the nature of this continuum may better inform the construction of taxonomies for both categories of behaviour. Both temperament and mental illness refer to patterns of behaviour that manifest over long time scales (weeks to years) and they appear to share many underlying neuroregulatory systems. This continuum is discussed from the perspectives of nonlinear dynamical systems theory, neurobiology and psychiatry as applied to understanding such multiscale time-series behaviour...
April 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
I Trofimova, T W Robbins, W H Sulis, J Uher
This Editorial highlights a unique focus of this theme issue on the biological perspectives in deriving psychological taxonomies coming from neurochemistry, neuroanatomy, neurophysiology, genetics, psychiatry, developmental and comparative psychology-as contrasted to more common discussions of socio-cultural concepts (personality) and methods (lexical approach). It points out the importance of the distinction between temperament and personality for studies in human and animal differential psychophysiology, psychiatry and psycho-pharmacology, sport and animal practices during the past century...
April 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Suli Zhao, Mohong Deng, Hengxing Cai, Qinggong Meng, Wei Fang, Jin Ke, Xing Long
The aim of this study was to explore the application and efficacy of personalized digital guiding plate-aided radiofrequency in treating trigeminal neuralgia (TN). A total of 117 cases (93 patients) of TN from January 2015 to December 2016 were divided into the study group (n = 53) and the traditional group (n = 64). Patients in the study group were treated by the radiofrequency through a personalized digital guiding plate, whereas those in the traditional group were treated by the traditional method...
February 23, 2018: Journal of Craniofacial Surgery
Danni Zhou, Xiaoming Wang, Guokang Chen, Suli Sun, Yang Yang, Zhendong Zhu, Canxing Duan
Fusarium verticillioides , F. proliferatum , and F. meridionale were identified as the predominant fungi among 116 Fusarium isolates causing maize ear and kernel rot, a destructive disease in Chongqing areas, China. The toxigenic capability and genotype were determined by molecular amplification and toxin assay. The results showed that the key toxigenic gene FUM1 was detected in 47 F. verticillioides and 19 F. proliferatum isolates. Among these, F. verticillioides and F. proliferatum isolates mainly produced fumonisin B₁, ranging from 3...
February 22, 2018: Toxins
Kelsey P Ringer, Mark G Roth, Mitchell S Garey, Ted B Piorczynski, Arminda Suli, Jason M Hansen, Jonathan K Alder
CRISPR-Cas technology has revolutionized genome engineering. While Cas9 was not the first programmable endonuclease identified, its simplicity of use has driven widespread adoption in a short period of time. While CRISPR-Cas genome editing holds enormous potential for clinical applications, its use in laboratory settings for genotype-phenotype studies and genome-wide screens has led to breakthroughs in the understanding of many molecular pathways. Numerous protocols have been described for introducing CRISPR-Cas components into cells, and here we sought to simplify and optimize a protocol for genome editing using readily available and inexpensive tools...
February 19, 2018: Cell Biology International
Edina Szekeres, Cecilia Maria Chiriac, Andreea Baricz, Tiberiu Szőke-Nagy, Ildiko Lung, Maria-Loredana Soran, Knut Rudi, Nicolae Dragos, Cristian Coman
Groundwater is an essential public and drinking water supply and its protection is a goal for global policies. Here, we investigated the presence and prevalence of antibiotic residues, antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and microbial contamination in groundwater environments at various distances from urban areas. Antibiotic concentrations ranged from below detection limit to 917 ng/L, being trimethoprim, macrolide, and sulfonamide the most abundant antibiotic classes. A total of eleven ARGs (aminoglycoside, β-lactam, chloramphenicol, Macrolide-Lincosamide-Streptogramin B - MLSB, sulfonamide, and tetracycline), one antiseptic resistance gene, and two MGEs were detected by qPCR with relative abundances ranging from 6...
February 14, 2018: Environmental Pollution
Chao Zhong, Suli Sun, Liangliang Yao, Junjie Ding, Canxing Duan, Zhendong Zhu
Phytophthora root rot (PRR) caused by Phytophthora sojae is a major soybean disease that causes severe economic losses worldwide. Using soybean cultivars carrying a Rps resistance gene is the most effective strategy for controlling this disease. We previously detected a novel Phytophthora resistance gene, RpsZS18 , on chromosome 2 of the soybean cultivar Zaoshu18. The aim of the present study was to identify and finely map RpsZS18 . We used 232 F2:3families generated from a cross between Zaoshu18 (resistant) and Williams (susceptible) as the mapping population...
2018: Frontiers in Plant Science
Xujun Song, Suli Zheng, Gang Yang, Guangbing Xiong, Zhe Cao, Mengyu Feng, Taiping Zhang, Yupei Zhao
Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucagonoma by evaluating 623 reported cases. A 1998 study reviewed 407 cases and 216 cases were reported in studies published after 1998. The current review consisted of 268 males and 339 females, with an average age of 52...
March 2018: Oncology Letters
Quanxiao Li, Gang Yang, Mengyu Feng, Suli Zheng, Zhe Cao, Jiangdong Qiu, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang, Yupei Zhao
Pancreatic cancer is considered a lethal disease with a high mortality and an extremely low five-year survival rate. Chemotherapy plays a pivotal role in pancreatic cancer treatment both in an adjuvant setting after complete resection and in the case of unresectable metastatic disease. However, none of the available combination chemotherapy regimens has resulted in satisfactory survival outcomes. Recent studies have revealed that both constitutive and induced activation of nuclear factor kappa B (NF-κB) in pancreatic cancer cells are closely associated with cell proliferation, invasion, anti-apoptosis, inflammation, angiogenesis and chemotherapeutic resistance...
February 9, 2018: Cancer Letters
Xiaohua Li, Chong Liu, Yongxing Chen, Hongkun Huang, Tianzhi Ren
A survey was conducted in regions of North China to better understand the effect of antibiotic residue pollution from swine feedlots to nearby groundwater environment. A total of nine experimental sites located in the regions of Beijing, Hebei, and Tianjin were selected to analyze the presence of residues of 11 most commonly used antibiotics, including tetracyclines (TCs), fluoroquinolones (FQNs), sulfonamides (SAs), macrolides, and fenicols, by using liquid chromatography spectrometry. The three most common antibiotics were TCs, FQNs, and SAs, with mean concentrations of 416...
February 9, 2018: Environmental Science and Pollution Research International
Jingwei Bian, Suli Zhang, Ming Yi, MingmingYue, Huirong Liu
The internalization of angiotensin II type 1 receptor (AT 1 R) plays an important role in maintaining cardiovascular homeostasis. Decreased receptor internalization is closely related to cardiovascular diseases induced by the abnormal activation of AT 1 R, such as hypertension. However, the mechanism behind reduced AT 1 R internalization is not fully understood. This review focuses on four parts of the receptor internalization process (the combination of agonists and receptors, receptor phosphorylation, endocytosis, and recycling) and summarizes the possible mechanisms by which AT 1 R internalization is reduced based on these four parts of the process...
February 6, 2018: Vascular Pharmacology
Ying Liu, Suli Liu, Yu Wang, Qinghua Zhang, Lin Gu, Shuchen Zhao, Dongdong Xu, Yafei Li, Jianchun Bao, Zhihui Dai
The construction of highly efficient and stable Pt-free catalysts for electrochemical hydrogen generation is highly desirable. Herein, we demonstrate the first metal-phosphides-metal system consisting of Ru, Ni2P and Ni, which forms unique multi-heterogeneous Ni@Ni2P-Ru nanorods. Interestingly, a Ru modulation effects that promotes the desorption of H2 to achieve a moderate hydrogen adsorption energy (ΔGH), and enables the formation of Ni@Ni2P nanorods via Ru-Ni coordination to enhance the conductivity was discovered...
February 7, 2018: Journal of the American Chemical Society
Abdollah Derakhshandeh, Vida Eraghi, Azar Motamedi Boroojeni, Malihe Akbarzadeh Niaki, Sahar Zare, Zahra Naziri
Escherichia coli (E. coli) is a normal flora of gastrointestinal tracts of humans and warm-blooded animals including dogs that has close vicinity with humans. Because the inter-species transmission of E. coli between pets and human beings, within a household, obtaining more information about the epidemiology, genetics, virulence factors, and antibiotic resistance of E. coli from dogs and their owners will help to control the inter-species transmission and treatment of E. coli infections. In this study we characterize and compare the antibiotic resistance and virulence profiles of fecal E...
January 30, 2018: Microbial Pathogenesis
Xiao-Li Yang, Shuai Zhang, Hua Li, Li-Min Zhang, Hai-Liang Song, Ya-Wen Wang
Few studies have been performed on both the potential and the risks of biofilm-electrode reactors (BERs) with regard to the removal of antibiotics. This study used 33 BERs to investigate the removal rate and degradation pathway of sulfadiazine (SDZ). Furthermore, the effects of additional electrons on sul genes and microbial community composition were examined. The study found that rapid elimination rates of 20mg/L SDZ were observed during the first 3h with different DC voltage rates. Even high concentrations (160mg/L) could be rapidly removed after 24h of system operation...
February 1, 2018: Ecotoxicology and Environmental Safety
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