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https://www.readbyqxmd.com/read/29751310/a-continuous-flow-mfc-cw-coupled-with-a-biofilm-electrode-reactor-to-simultaneously-attenuate-sulfamethoxazole-and-its-corresponding-resistance-genes
#1
Hua Li, Hai-Liang Song, Xiao-Li Yang, Shuai Zhang, Yu-Li Yang, Li-Min Zhang, Han Xu, Ya-Wen Wang
A continuous flow microbial fuel cell constructed wetland (MFC-CW) coupled with a biofilm electrode reactor (BER) system was constructed to remove sulfamethoxazole (SMX). The BER unit powered by the stacked MFC-CWs was used as a pretreatment unit, and effluent flowed into the MFC-CW for further degradation. The experimental results indicated that the removal rate of 2 or 4 mg/L SMX in a BER unit was nearly 90%, and the total removal rate in the coupled system was over 99%. As the hydraulic retention time (HRT) was reduced from 16 h to 4 h, the SMX removal rate in the BER decreased from 75% to 48%...
May 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29747614/there-is-more-to-mental-illness-than-negative-affect-comprehensive-temperament-profiles-in-depression-and-generalized-anxiety
#2
Irina Trofimova, William Sulis
BACKGROUND: Temperament and mental illness are thought to represent varying degrees along the same continuum of neurotransmitter imbalances. A taxonomy of temperament could provide the basis for a new taxonomy of mental illness. Most popular models of temperament, being based heavily on emotionality traits, show very poor ability to discriminate between mental disorders. The main goal of this study was to examine whether a temperament model based on modern neurophysiology and possessing an extensive set of non-emotionality traits provides better discrimination between Major Depression (MD), Generalized Anxiety (GAD) and Comorbid MD and GAD, in comparison to emotionality-based temperament models...
May 10, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29733265/effects-of-cage-farming-on-antimicrobial-and-heavy-metal-resistance-of-escherichia-coli-enterococcus-faecium-and-lactococcus-garvieae
#3
Mustafa Ture, Ilhan Altinok, Huseyin Alp
OBJECTIVE: To characterize antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) of Escherichia coli and Enterococcus faecium isolated from the sediment and Lactococcus garvieae isolated from fish. MATERIALS AND METHODS: The isolated bacteria were identified by sequencing 16S rRNA genes. After identification of the bacteria, tetracycline (tetA, tetB, tetD), erythromycin (ereA, ereB), sulfonamides (sulI, sulII), trimethoprim (dhfrA1), β-lactam (blaTEM , blaCTX , ampC), florfenicol (floR), and class 1 integron (Int1) resistance gene were then determined...
May 7, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29730523/sewage-sludge-drying-method-combining-pressurized-electro-osmotic-dewatering-with-subsequent-bio-drying
#4
Qian Li, Xuebin Lu, Haigang Guo, Zengjun Yang, Yingte Li, Suli Zhi, Keqiang Zhang
In this study, pressurized electro-osmotic dewatering (PEOD) as a pretreatment process, instead of the conventional practice of adding bulking agents, for sewage sludge bio-drying was proposed. Initially, various parameters were optimized for obtaining dewatered sewage sludge (DSS), treated by an efficient, quick, and energy-saving PEOD process. The results show that the moisture content (MC) of sewage sludge could decrease from 83.41% to 60.0% within 7.5 min in the optimum conditions of the PEOD process...
April 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29728694/outcome-of-children-with-multiply-relapsed-b-cell-acute-lymphoblastic-leukemia-a-therapeutic-advances-in-childhood-leukemia-lymphoma-study
#5
Weili Sun, Jemily Malvar, Richard Sposto, Anupam Verma, Jennifer J Wilkes, Robyn Dennis, Kenneth Heym, Theodore W Laetsch, Melissa Widener, Susan R Rheingold, Javier Oesterheld, Nobuko Hijiya, Maria Luisa Sulis, Van Huynh, Andrew E Place, Henrique Bittencourt, Raymond Hutchinson, Yoav Messinger, Bill Chang, Yousif Matloub, David S Ziegler, Rebecca Gardner, Todd Cooper, Francesco Ceppi, Michelle Hermiston, Luciano Dalla-Pozza, Kirk R Schultz, Paul Gaynon, Alan S Wayne, James A Whitlock
The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the outcome of multiply R/R childhood B-ALL treated at 24 TACL institutions between 2005 and 2013. Patient information, treatment, and response were collected. Prognostic factors influencing the complete remission (CR) rate and event-free survival (EFS) were analyzed...
March 15, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29723814/effect-of-uva-led-tio-2-photocatalysis-treated-sulfamethoxazole-and-trimethoprim-containing-wastewater-on-antibiotic-resistance-development-in-sequencing-batch-reactors
#6
Qinqing Cai, Jiangyong Hu
Controlling of antibiotics is the crucial step for preventing antibiotic resistance genes (ARGs) dissemination; UV photocatalysis has been identified as a promising pre-treatment technology for antibiotics removal. However, information about the effects of intermediates present in the treated antibiotics wastewater on the downstream biological treatment processes or ARGs development is very limited. In the present study, continuous UVA/LED/TiO2 photocatalysis removed more than 90% of 100 ppb sulfamethoxazole (SMX)/trimethoprim (TMP), the treated wastewater was fed into SBR systems for over one year monitoring...
April 24, 2018: Water Research
https://www.readbyqxmd.com/read/29717109/substitution-of-d701n-in-the-pb2-protein-could-enhance-the-viral-replication-and-pathogenicity-of-eurasian-avian-like-h1n1-swine-influenza-viruses
#7
Suli Liu, Wenfei Zhu, Zhaomin Feng, Rongbao Gao, Junfeng Guo, Xiyan Li, Jia Liu, Dayan Wang, Yuelong Shu
Eurasian avian-like H1N1 (EA H1N1) swine influenza viruses (SIVs) have become predominant in pig populations in China and have recently been reported to have the most potential to raise the next pandemic in humans. The mutation D701N in the PB2 protein, which accounts for 31% of H1N1 SIVs, has previously been shown to contribute to the adaptation of the highly pathogenic H5N1 or H7N7 avian influenza viruses in mammals. However, little is known of the effects of this substitution on the EA H1N1 viruses. Herein, we investigated the contributions of 701N in the PB2 protein to an EA H1N1 SIV (A/Hunan/42443/2015(H1N1), HuN EA-H1N1), which had 701D in the PB2 protein...
May 2, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29704483/the-potent-insulin-secretagogue-effect-of-betulinic-acid-is-mediated-by-potassium-and-chloride-channels
#8
Allisson Jhonatan Gomes Castro, Luisa Helena Cazarolli, Lizandra C Bretanha, Paola Miranda Sulis, Diana Patricia Rey Padilla, Diana Marcela Aragón Novoa, Betina Fernanda Dambrós, Moacir G Pizzolatti, Fátima Regina Mena Barreto Silva
Betulinic acid (BA) has been described as an insulin secretagogue which may explain its potent antihyperglycemic effect; however, the exact role of BA as an insulinogenic agent is not clear. The aim of this study was to investigate the mechanism of BA on calcium influx and static insulin secretion in pancreatic islets isolated from euglycemic rats. We found that BA triggers calcium influx by a mechanism dependent on ATP-dependent potassium channels and L-type voltage-dependent calcium channels. Additionally, the voltage-dependent and calcium-dependent chloride channels are also involved in the mechanism of BA, probably due to an indirect stimulation of calcium entry and increased intracellular calcium...
April 25, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29697782/the-inhibitory-effect-of-bkca-channels-induced-by-autoantibodies-against-angiotensin-ii-type-1-receptor-is-independent-of-at1r
#9
Peng Wang, Suli Zhang, Jie Ren, Li Yan, Lina Bai, Li Wang, Pengli Wang, Jingwei Bian, Xiaochen Yin, Huirong Liu
Autoantibodies against angiotensin II Type 1 receptor (AT1-AA) are routinely detected in the serum of preeclampsia patients, which results in an increase in vascular tone and an elevation in intracellular calcium concentration of rat vascular smooth muscle (VSM). The big conductance calcium-activated potassium channels (BKCa channels) account for the dominant outward currents in VSMCs, contributing to membrane hyperpolarization and vasodilation. In the present study, we investigated the effect of AT1-AA on BKCa channels...
April 25, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29677681/pphb22-a-member-of-hd-zip-proteins-activates-ppdam1-to-regulate-bud-dormancy-transition-in-suli-pear-pyrus-pyrifolia-white-pear-group
#10
Qinsong Yang, Qingfeng Niu, Jianzhao Li, Xiaoyan Zheng, Yunjing Ma, Songling Bai, Yuanwen Teng
Homeodomain-leucine zipper (HD-Zip) proteins, which form one of the largest and most diverse families, regulate many biological processes in plants, including differentiation, flowering, vascular development, and stress signaling. Abscisic acid (ABA) has been proved to be one of the key regulators of bud dormancy and to influence several HD-Zip genes expression. However, the role of HD-Zip genes in regulating bud dormancy remains unclear. We identified 47 pear (P. pyrifolia White Pear Group) HD-Zip genes, which were classified into four subfamilies (HD-Zip I-IV)...
April 5, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29668605/patients-with-mild-paraquat-poisoning-treated-with-prolonged-low-dose-methylprednisolone-have-better-lung-function-a-retrospective-analysis
#11
Jie Gao, Zongxun Cao, Shunyi Feng, Yangying Song, Wenjing Bai, Shumin Zhao, Suli Zhang, Yong Li
Lung dysfunction is an important characteristic of injury induced by paraquat (PQ). This study aimed to evaluate the effects of prolonged low-dose methylprednisolone (MP) treatment on lung function in patients with mild PQ poisoning. We analyzed the results of lung function testing in all patients with mild PQ poisoning admitted to Cangzhou Central Hospital between January 2012 and August 2017. Patients were grouped according to short-term treatment (3 mg/kg/day MP for 3 days) or prolonged treatment (3 mg/kg/day MP for 3 days, followed by dosage reduction by half every 3 days, with treatment terminated when a dosage of 0...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29615098/mir-10a-5p-targets-tfap2c-to-promote-gemcitabine-resistance-in-pancreatic-ductal-adenocarcinoma
#12
Guangbing Xiong, Hua Huang, Mengyu Feng, Gang Yang, Suli Zheng, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang, Yupei Zhao
BACKGROUND: By regulating target genes, microRNAs play essential roles in carcinogenesis and drug resistance in human pancreatic ductal adenocarcinoma (PDAC). Previous studies have shown that microRNA-10a-5p (miR-10a-5p) is overexpressed in PDAC and acts as an oncogene to promote the metastatic behavior of PDAC cells. However, the role of miR-10a-5p in PDAC chemoresistance remains unclear. METHODS: The effects of miR-10a-5p on biological behaviors were analyzed...
April 3, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29603593/phase-i-trial-of-the-mtor-inhibitor-everolimus-in-combination-with-multi-agent-chemotherapy-in-relapsed-childhood-acute-lymphoblastic-leukemia
#13
Andrew E Place, Yana Pikman, Kristen E Stevenson, Marian H Harris, Melinda Pauly, Maria-Luisa Sulis, Nobuko Hijiya, Lia Gore, Todd M Cooper, Mignon L Loh, Giovanni Roti, Donna S Neuberg, Sarah K Hunt, Sarah Orloff-Parry, Kimberly Stegmaier, Stephen E Sallan, Lewis B Silverman
BACKGROUND: We sought to determine the feasibility of co-administering everolimus with a four-drug reinduction in children and adolescents with acute lymphoblastic leukemia (ALL) experiencing a first marrow relapse. PROCEDURE: This phase I study tested everolimus with vincristine, prednisone, pegaspargase and doxorubicin in patients with marrow relapse occurring >18 months after first complete remission (CR). The primary aim was to identify the maximum tolerated dose of everolimus...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29600711/jq-1-inhibits-colon-cancer-proliferation-via-suppressing-wnt-%C3%AE-catenin-signaling-and-mir-21
#14
Yan Zhang, Suli Tian, Jidong Xiong, Yongxu Zhou, Hongyu Song, Chang Liu
Bromodoamin and extraterminal (BET) protein inhibitors are a novel class of cancer therapeutics. Here we aim to investigate the efficacy and mechanism of JQ-1, a potent BET inhibitor, in colon cancer therapy. JQ-1 was used to treat SW480 colon cancer mouse xenografts. Tumor size and mouse survival were recorded. Cell apoptosis was evaluated by Annex V-FIC/PI flow cytometry. ChIP-q-PCR analysis was used to assess the H3K27 trimethylation (H3K27m3) of the p16 promoter. Wnt signaling was evaluated by Nkd2 and β-catenin levels...
March 30, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29589280/response-to-cyclosporine-a-and-corticosteroids-in-adult-patients-with-acquired-pure-red-cell-aplasia-serial-experience-at-a-single-center
#15
Xuemei Wu, Suli Wang, Xingyu Lu, Wenyi Shen, Chun Qiao, Yujie Wu, Ruinan Lu, Shuai Wang, Jianfu Zhang, Ming Hong, Yu Zhu, Jianyong Li, Guangsheng He
To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immunosuppressive agents on becoming refractory and relapse. Thirty-nine patients were evaluated. Remission induction therapy included CsA (n = 16), CS (n = 13), CsA in combination with CS (n = 6), or other immunosuppressive agents (n = 4)...
March 27, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29581724/behaviour-of-the-foramen-ovale-flow-in-fetuses-with-intrauterine-growth-restriction
#16
Ângela R L Nader, Paulo Zielinsky, Alexandre Antonio Naujorks, Luiz Henrique S Nicoloso, Antonio Luiz Piccoli Junior, Natássia Miranda Sulis, Luiza Ferreira van der Sand, Victoria de Bittencourt Antunes, Gabriela Dos Santos Marinho, Fernanda Greinert Dos Santos, Natan Pereira Gosmann, Eduardo Becker Júnior, Renato Frajndlich, Tamara Beherens, Marcelo Brandão da Silva, Caroline Barbisan, Stefano Busato, Mauro Lopes, Caroline Klein
Background: Foramen ovale (FO) flow may be altered in IUGR. This study was designed to test this hypothesis. Methods: Forty pregnant women (24-38 weeks) were divided into 3 groups: group I (IUGR), group II (adequate growth and maternal hypertension), and group III (normal controls). Impedance across the FO was assessed by the FO pulsatility index (FOPI): (systolic velocity - presystolic velocity)/mean velocity. Statistical analysis utilized ANOVA, Tukey test, and ROC curves...
2018: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/29569050/anaerobic-digestion-performance-of-sweet-potato-vine-and-animal-manure-under-wet-semi-dry-and-dry-conditions
#17
Enlan Zhang, Jiajia Li, Keqiang Zhang, Feng Wang, Houhua Yang, Suli Zhi, Guangqing Liu
Sweet potato vine (SPV) is an abundant agricultural waste, which is easy to obtain at low cost and has the potential to produce clean energy via anaerobic digestion (AD). The main objectives of this study were to reveal methane production and process stability of SPV and the mixtures with animal manure under various total solid conditions, to verify synergetic effect in co-digestion of SPV and manure in AD systems, and to determine the kinetics characteristics during the full AD process. The results showed that SPV was desirable feedstock for AD with 200...
March 22, 2018: AMB Express
https://www.readbyqxmd.com/read/29556254/immunological-changes-of-t-helper-cells-in-flow-cytometer-sorted-cd4-t-cells-from-patients-with-hashimoto-s-thyroiditis
#18
Yanying Guo, Jazyra Zynat, Shuqing Xing, Liang Xin, Suli Li, Nurongguli Mammat, Yuan Chen, Limin Zhao, Hongli Zhao, Xinling Wang
Recent incidence rates for Hashimoto's thyroiditis (HT) and hypothyroidism are higher than those of previous studies. Previous studies indicated that T helper cells may have a major role in the pathogenesis and development of HT, but there is no consensus in the literature. The aim of the present study was to explore the peripheral T helper cell response in the different stages of HT. In this cross-sectional study, we performed flow cytometry analysis to determine the various T cell subsets of 389 patients with HT (34 patients with HT who developed overt hypothyroidism, and 148 patients with HT who developed subclinical hypothyroidism), as well as 51 healthy controls...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29550813/a-role-for-receptor-interacting-protein-kinase-1-in-neutrophil-extracellular-trap-formation-in-patients-with-systemic-lupus-erythematosus-a-preliminary-study
#19
Ruru Guo, Yang Tu, Shaowei Xie, Xue Song Liu, Yang Song, Suli Wang, Xiaoxiang Chen, Liangjing Lu
BACKGROUND/AIMS: Neutrophil extracellular traps (NETs) are known to play an important role in systemic lupus erythematosus (SLE) by triggering innate and adaptive immune responses. The molecular mechanisms responsible for their formation in SLE are still unclear. In this study, we aim to characterize the role of the receptor-interacting protein kinase-1 (RIPK1), a homologous serine/threonine kinase previously implicated in the regulation of necroptosis and tissue injury, in decreasing neutrophil death and formation of NETs, and to investigate the clinical implications of RIPK1 in SLE...
March 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29540670/decreased-autophagy-induced-by-%C3%AE-1-adrenoceptor-autoantibodies-contributes-to-cardiomyocyte-apoptosis
#20
Li Wang, Yang Li, Na Ning, Jin Wang, Zi Yan, Suli Zhang, Xiangying Jiao, Xiaohui Wang, Huirong Liu
It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-β1 -adrenergic receptor autoantibodies (β1 -AABs) decreased myocardial autophagy, but the role of decreased autophagy in cardiomyocyte apoptosis remains unclear. In the present study, we used a β1 -AAB-immunized rat model to investigate the role of decreased autophagy in cardiomyocyte apoptosis. We reported that the level of autophagic flux increased early and then decreased in an actively β1 -AAB-immunized rat model...
March 14, 2018: Cell Death & Disease
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