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https://www.readbyqxmd.com/read/28929113/impact-of-fish-oil-supplementation-and-interruption-of-fructose-ingestion-on-glucose-and-lipid-homeostasis-of-rats-drinking-different-concentrations-of-fructose
#1
Paola M Sulis, Katia Motta, Amanda M Barbosa, Matheus H Besen, Julia S da Silva, Everson A Nunes, Alex Rafacho
Background. Continuous fructose consumption may cause elevation of circulating triacylglycerol. However, how much of this alteration is reverted after the removal of fructose intake is not known. We explored this question and compared the efficacy of this approach with fish oil supplementation. Methods. Male Wistar rats were divided into the following groups: control (C), fructose (F) (water intake with 10% or 30% fructose for 9 weeks), fish oil (FO), and fructose/fish oil (FFO). Fish oil was supplemented only for the last 33 days of fructose ingestion...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28925370/controlled-preparation-of-m-ag-au-tio-sub-2-sub-through-sulfydryl-assisted-method-for-enhanced-photocatalysis
#2
Hongbo Xia, Suli Wu, Jiajie Bi, Shufen Zhang
Here a simple and effective method was explored to fabricate M/TiO<sub>2</sub> (M=Ag, Au) composites, which required neither pre-treatment of TiO<sub>2</sub> nor any additives as reducing agent. Using amorphous TiO<sub>2</sub> spheres functionalized with SH groups as starting materials, the noble metallic ions (Ag, Au) can be adsorbed by TiO<sub>2</sub> due to their special affinity with SH groups, which is beneficial to the uniform dispersion of metallic ions on the surface of TiO<sub>2</sub>...
September 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28923155/modeling-stochastic-complexity-in-complex-adaptive-systems-non-kolmogorov-probability-and-the-process-algebra-approach
#3
William H Sulis
Walter Freeman III pioneered the application of nonlinear dynamical systems theories and methodologies in his work on mesoscopic brain dynamics.Sadly, mainstream psychology and psychiatry still cling to linear correlation based data analysis techniques, which threaten to subvert the process of experimentation and theory building. In order to progress, it is necessary to develop tools capable of managing the stochastic complexity of complex biopsychosocial systems, which includes multilevel feedback relationships, nonlinear interactions, chaotic dynamics and adaptability...
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28923153/introduction-walter-j-freeman-iii-january-30-1927-april-24-2016
#4
William H Sulis, Irina Trofimova
No abstract text is available yet for this article.
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28902004/antiretroviral-therapy-in-hiv-infected-children-with-tuberculosis-a-systematic-review
#5
Giorgia Sulis, Silvia Amadasi, Anna Odone, Martina Penazzato, Alberto Matteelli
BACKGROUND: Tuberculosis is the major cause of mortality in HIV-infected children globally. Current guidelines about the management of antiretroviral therapy in children with tuberculosis are based on a limited number of non-randomized studies involving small numbers of participants. The aim of the study was to systematically retrieve and critically appraise available evidence on the efficacy and safety of different antiretroviral regimens in children with HIV infection who are receiving treatment for active tuberculosis...
September 7, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28886881/pahs-accelerate-the-propagation-of-antibiotic-resistance-genes-in-coastal-water-microbial-community
#6
Jing Wang, Jing Wang, Zelong Zhao, Jingwen Chen, Hong Lu, Guangfei Liu, Jiti Zhou, Xiaoyan Guan
Antibiotic resistance genes (ARGs) have been regarded as emerging contaminants and have attracted growing attention owing to their widespread presence in the environment. In addition to the well-documented selective pressure of antibiotics, ARGs have also become prevalent because of anthropogenic impacts. Coastal habitats are located between terrestrial and marine ecosystems, which are a hotspot for anthropogenic impacts. Excessive accumulation of polycyclic aromatic hydrocarbons (PAHs) has posed a serious threat to coastal habitats, but no information is available on the effect of PAHs on antibiotic resistance in the microbial community of coastal environments...
September 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28866406/rapid-startup-of-thermophilic-anaerobic-digester-to-remove-tetracycline-and-sulfonamides-resistance-genes-from-sewage-sludge
#7
Rui Xu, Zhao-Hui Yang, Qing-Peng Wang, Yang Bai, Jian-Bo Liu, Yue Zheng, Yan-Ru Zhang, Wei-Ping Xiong, Kito Ahmad, Chang-Zheng Fan
Spread of antibiotic resistance genes (ARGs) originating from sewage sludge is highlighted as an eminent health threat. This study established a thermophilic anaerobic digester using one-step startup strategy to quickly remove tetracycline and sulfonamides resistance genes from sewage sludge. At least 20days were saved in the startup period from mesophilic to thermophilic condition. Based on the results of 16S rDNA amplicons sequencing and predicted metagenomic method, the successful startup largely relied on the fast colonization of core thermophilic microbial population (e...
August 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28860086/assessing-the-impact-of-charge-variants-on-stability-and-viscosity-of-a-high-concentration-antibody-formulation
#8
Shantanu V Sule, Jason E Fernandez, Vincent J Mecozzi, Yana Kravets, William C Yang, Pamela Feng, Suli Liu, Li Zang, Allan D Capili, Tia B Estey, Kapil Gupta
Characterizing molecular charge variants or isoforms is essential for understanding safety, potency and bioavailability of antibody therapeutics. However, there is little information on how they influence stability and viscosity - properties governing immunogenicity and delivery. To bridge this gap, we studied antibody stability as a function of charge variant content generated via bioreactor process. We were able to systematically vary acidic variant levels as a function of bioreactor harvest time. Importantly, we do not observe any impact on aggregation behavior of a formulated antibody at high protein concentration as a function of acidic variant level...
August 28, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28857499/control-synthesis-of-pbs-tio%C3%A2-hollow-hybrid-structures-through-ion-adsorption-heating-progress-and-their-photocatalytic-activity
#9
Hongbo Xia, Suli Wu, Shufen Zhang
Hollow hybrid nanostructure has received significant attention because of its unique structural features. This study reports a facile "ion adsorption-heating" method to fabricate PbS-TiO₂ hybrid hollow particles. In this method, the TiO₂ spheres used as substrate material to grow PbS are aggregates of many small amorphous TiO₂ particles, and each of the small particles is covered by thioglycollic acid ligands through Ti4+-carboxyl coordination. When the Pb2+ ions were added into the TiO₂ spheres colloidal solution, these ions can be adsorbed by sulfydryl (-SH) groups to form metal thiolate, and the C-S bond will be dissociated by heating to release S2-...
August 31, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28826722/pd-1-pd-l1-and-immunotherapy-for-pancreatic-cancer
#10
Mengyu Feng, Guangbing Xiong, Zhe Cao, Gang Yang, Suli Zheng, Xujun Song, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Therapy that targets programmed death 1 or programmed death 1 ligand 1 (PD-1/PD-L1), which are known as immune checkpoints, has been recently rapidly developing as oncotherapy for various carcinomas. However, this therapy has a poor effect on the treatment of pancreatic cancer with PD-1/PD-L1 blockade monotherapy. In this review, the development and limitations of anti-PD-1/PD-L1 monotherapy in pancreatic cancer are discussed. We then consider the underlying mechanism of anti-PD-1/PD-L1 monotherapy failure, combination strategies overcoming resistance to anti-PD-1/PD-L1 immunotherapy and the prospect of targeting PD-1/PD-L1 for the immunotherapy of pancreatic cancer...
October 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28810864/molecular-determination-of-antimicrobial-resistance-in-escherichia-coli-isolated-from-raw-meat-in-addis-ababa-and-bishoftu-ethiopia
#11
Yohannes Equar Messele, Reta Duguma Abdi, Shimels Tikuye Yalew, Desiye Tesfaye Tegegne, Bezina Arega Emeru, Gebremeskel Mamu Werid
BACKGROUND: Consumption of meat contaminated by E. coli causes a serious illness and even death to affected individuals. Recently the emerging of antibiotic resistant foodborne E. coli poses serious public health risks worldwide. However, little is known about the antibiotic resistance profile of E. coli in Ethiopia. This study aimed to determine the prevalence and Antimicrobial resistance (AMR) status of E. coli isolated from different type of meat. METHODS: Overall 292 samples were collected from December 2015 to April 2016 from slaughterhouses to determine the prevalence and AMR of E...
August 15, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28800142/alcohol-mediated-missplicing-of-mcl-1-pre-mrna-is-involved-in-neurotoxicity
#12
Rahsan Sariyer, Francesca I De-Simone, Martina Donadoni, Jan B Hoek, Sulie L Chang, Ilker Kudret Sariyer
BACKGROUND: Heavy and chronic ethanol (EtOH) exposure can cause significant structural and functional damage to the adult brain. The most devastating consequence of EtOH exposure is the neurotoxicity associated with the depletion of neurons. Regulation of splice variants in the brain can modulate protein functions, which may ultimately affect behaviors associated with alcohol dependence and EtOH-mediated neurotoxicity. As alcohol consumption is associated with neurotoxicity, it is possible that altered splicing of survival and pro-survival factors during the development of alcoholism may contribute to the neurotoxicity...
August 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28741317/significantly-enhanced-hydrogen-evolution-activity-of-freestanding-pd-ru-distorted-icosahedral-clusters-with-less-than-600-atoms
#13
Zhihui Dai, Suli Liu, Qinghua Zhang, Jianchun Bao, Yafei Li, Lin Gu
Freestanding metal nanoclusters can tune, precisely and effectively, the Gibbs free energy (ΔGH) of atomic hydrogen on the surface of materials. This enables the enhancement of hydrogen evolution activity. In this paper, we report a study of freestanding Pd-Ru distorted icosahedral clusters (ico-clusters) with less than 600 atoms using a simple one-pot synthesis method. This Pd-Ru ico-cluster can be used as an efficient electrocatalyst for the hydrogen evolution reaction (HER) in acidic water, which is a promising alternative to Pt...
July 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28732787/molecular-characterization-and-antimicrobial-resistance-profile-of-atypical-citrobacter-gillenii-and-citrobacter-sp-isolated-from-diseased-rainbow-trout-oncorhynchus-mykiss
#14
Muhammed Duman, Izzet Burcin Saticioglu, Ayse Gul Buyukekiz, Fikri Balta, Soner Altun
AIM: Over the last decade, Citrobacter species have been responsible for infections in fish and many species and also new Citrobacter species have been identified. In this study, molecular identifications and the phenotypic and genotypic antimicrobial-resistance characteristics of atypical and typical Citrobacter species were determined. MATERIALS AND METHODS: Seven Citrobacter isolates were investigated from rainbow trout of different lengths with signs of disease...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28726129/immunological-aspects-of-rabies-a-literature-review
#15
REVIEW
Iana Suly Santos Katz, Fernanda Guedes, Elaine Raniero Fernandes, Sandriana Dos Ramos Silva
Rabies is a lethal disease caused by the neurotropic virus rabies virus (RABV), and it remains an important public health problem globally. It is known that the host immune response is important for control of viral infection and promoting viral clearance. In this context, it is well documented that, in addition to RABV neutralizing antibody, interferons and cell-mediated immunity also have an important role in preventing the establishment of disease. On the other hand, RABV suppresses host immunity through different mechanisms, for example, direct inhibition of host gene expression, sequestration of pathogen-associated molecular patterns, or modification of cytokine signalling pathways, which hinder the protective host immune responses to RABV infection...
July 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28722442/sensing-active-heparin-by-counting-aggregated-quantum-dots-at-single-particle-level
#16
Suli Dong, Xiaojun Liu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Aiye Liang, Hongwei Gai
Developing highly sensitive and highly selective assays for monitoring heparin levels in blood is required during and after surgery. In previous studies, electrostatic interactions are exploited to recognize heparin and changes in light signal intensity are used to sense heparin. In the present study, we developed a quantum dot (QD) aggregation-based detection strategy to quantify heparin. When cationic micelles and fluorescence QDs modified with anti-thrombin III (AT III) are added into heparin sample solution, the AT III-QDs, which specifically bind with heparin, aggregate around the micelles...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28706609/distribution-of-class-i-integron-and-smqnr-resistance-gene-among-stenotrophomonas-maltophilia-isolated-from-clinical-samples-in-iran
#17
Mohammadali Malekan, Bahman Tabaraie, Ladan Akhoundtabar, Parviz Afrough, Ava Behrouzi
BACKGROUND: Stenotrophomonas maltophilia (S. maltophilia) is a multiple-antibiotic-resistant opportunistic pathogen that is being isolated with increasing frequency from patients with health-care-associated infections. S. maltophilia is inherently resistant to most of the available antimicrobial agents. Spread of resistant strains has been attributed, in part, to class I integrons. In vitro susceptibility studies have shown trimethoprim-sulfamethoxazole and new floroquinolones as two important agents with activity against these organisms...
July 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28702913/time-series-analysis-of-ambient-air-pollution-effects-on-daily-mortality
#18
Yinsheng Guo, Yue Ma, Yanwei Zhang, Suli Huang, Yongsheng Wu, Shuyuan Yu, Fei Zou, Jinquan Cheng
Although the growths of ambient pollutants have been attracting public concern, the characteristic of the associations between air pollutants and mortality remains elusive. Time series analysis with a generalized additive model was performed to estimate the associations between ambient air pollutants and mortality outcomes in Shenzhen City for the period of 2012-2014. The results showed that nitrogen dioxide (NO2)-induced excess risks (ER) of total non-accidental mortality and cardiovascular mortality were significantly increased (6...
July 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28687424/identification-by-serological-proteome-analysis-of-paramyosin-as-prominent-allergen-in-dust-mite-allergy
#19
Antonio Conti, Giulia J Burastero, Claudia Suli, Srinita Banerjee, Susanne Vrtala, Massimo Alessio, Samuele E Burastero
Component-resolved diagnosis (CRD) of IgE-mediated hypersensitivities is challenged by the possibility that single patients are sensitized to components not commercially available to the clinical lab. Here, we studied a patient with positive extract-based diagnosis of house dust mite (HDM) allergy based on routine in vivo (prick test) and in vitro (serum specific IgE) tests, whose serum scored negative for IgE to the three recombinant allergens routinely used in CRD (group 1 allergens, group 2 allergens and tropomyosin)...
July 4, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28674052/characterization-of-a-large-antibiotic-resistance-plasmid-found-in-enteropathogenic-escherichia-coli-strain-b171-and-its-relatedness-to-plasmids-of-diverse-e-coli-and-shigella-strains
#20
Tracy H Hazen, Jane Michalski, Sushma Nagaraj, Iruka N Okeke, David A Rasko
Enteropathogenic Escherichia coli (EPEC) is a leading cause of severe infantile diarrhea in developing countries. Previous research has focused on the diversity of the EPEC virulence plasmid, whereas less is known regarding the genetic content and distribution of antibiotic resistance plasmids carried by EPEC. A previous study demonstrated that in addition to the virulence plasmid, reference EPEC strain B171 harbors a second, larger plasmid that confers antibiotic resistance. To further understand the genetic diversity and dissemination of antibiotic resistance plasmids among EPEC strains, we describe the complete sequence of an antibiotic resistance plasmid from EPEC strain B171...
September 2017: Antimicrobial Agents and Chemotherapy
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