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femoral neck fractures

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https://www.readbyqxmd.com/read/29777918/sex-differences-in-the-spatial-distribution-of-bone-in-relation-to-incident-hip-fracture-findings-from-the-ages-reykjavik-study
#1
Elisa A Marques, Julio Carballido-Gamio, Vilmundur Gudnason, Gunnar Sigurdsson, Sigurdur Sigurdsson, Thor Aspelund, Kristin Siggeirsdottir, Lenore Launer, Gudny Eiriksdottir, Thomas Lang, Tamara B Harris
In this case-cohort study, we used data-driven computational anatomy approaches to assess within and between sex spatial differences in proximal femoral bone characteristics in relation to incident hip fracture. One hundred male and 234 female incident hip fracture cases, and 1047 randomly selected noncase subcohort participants (562 female) were chosen from the population-based AGES-Reykjavik study (mean age of 77 years). The baseline -i.e. before hip fracture- hip quantitative computed tomography scans of these subjects were analyzed using voxel-based morphometry, tensor-based morphometry, and surface-based statistical parametric mapping to assess the spatial distribution of volumetric bone mineral density (vBMD), internal structure, and cortical bone properties (thickness, vBMD and trabecular vBMD adjacent to the endosteal surface) of the proximal femur, respectively, in relation to incident hip fracture...
May 16, 2018: Bone
https://www.readbyqxmd.com/read/29775946/il-9-exhibits-elevated-expression-in-osteonecrosis-of-femoral-head-patients-and-promotes-cartilage-degradation-through-activation-of-jak-stat-signaling-in-vitro
#2
Wei Geng, Wen Zhang, Jinzhu Ma
Osteonecrosis of the femoral head (ONFH) often causes severe symptoms in young people and limits the mobility of the hip joint. Interleukin-9 (IL-9) is a multi-functional inflammatory factor that participates in lumbar disk herniation and arthritis and has been reported in many studies. However, the correlation between IL-9 and ONFH is unclear. The present study aimed to determine the role of IL-9 in the pathogenetic mechanism of osteonecrosis. To assess IL-9 expression in ONFH and femoral neck fracture patients, cartilage tissue was examined through western blot analysis and immunohistochemistry...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29774866/femoral-neck-stress-fracture-in-a-young-female-recruit-case-report
#3
Hélder Fonte, Ricardo Rodrigues-Pinto
INTRODUCTION: Femoral neck stress fractures are uncommon and depending on their location, can be at high risk for non-union and significant morbidity.  Their prevalence is higher among runners and military recruits, and women seem to be at higher risk. METHODS: A 27-year-old female, who was enrolled in military recruit, reported left side groin pain after a strenuous running exercise. Due to persistent pain an X-Ray was ordered, which revealed no signs of acute lesions...
2018: SICOT-J
https://www.readbyqxmd.com/read/29774403/anti-osteoporosis-drug-use-too-little-too-much-or-just-right-the-hunt-study-norway
#4
M Hoff, S Skurtveit, H E Meyer, A Langhammer, A J Søgaard, U Syversen, E Skovlund, B Abrahamsen, S Forsmo, B Schei
Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50-85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% of the men received AODs. The strongest predictors for AODs were high age in women and use of glucocorticoids among men. INTRODUCTION: To examine the use of anti-osteoporotic drugs (AODs) and to identify predictors for prescriptions. METHODS: Data were obtained from the Nord-Trøndelag Health Study (HUNT3) performed in 2006-2008 and the Norwegian Prescription Database, including 15,075 women and 13,386 men aged 50-85 years...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774402/subtrochanteric-and-diaphyseal-femoral-fractures-in-hypophosphatasia-not-atypical-at-all
#5
F Genest, L Seefried
Risk for subtrochanteric and diaphyseal femoral fractures is considered increased in patients with hypophosphatasia (HPP). Evaluating a large cohort of HPP patients, we could for the first time quantify the prevalcence and identify both morphometric features as well as predisposing factors for this complication of severe HPP. INTRODUCTION: Subtrochanteric and diaphyseal femoral fractures have been associated with both, long-term antiresorptive treatment and metabolic bone disorders, specifically Hypophosphatasia (HPP)...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29770880/intraoperative-periprosthetic-femur-fracture-during-bipolar-hemiarthroplasty-for-displaced-femoral-neck-fractures
#6
Choon Chiet Hong, Nazrul Nashi, Jiong Hao Tan, Ruben Manohara, Wei Ting Lee, Diarmuid Paul Murphy
INTRODUCTION: We aim to review the incidence and risk factors for the development of intraoperative periprosthetic femur fractures while performing a bipolar hemiarthroplasty for displaced neck of femur fractures. Our secondary aim is to characterize the types of intraoperative periprosthetic fractures, the steps leading to the fractures, and the salvage treatments instituted. MATERIALS AND METHODS: 271 patients treated with bipolar hemiarthroplasty after traumatic displaced femoral neck fractures were retrospectively analyzed...
May 17, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29770222/recurrent-vertebral-fractures-in-a-young-adult-a-closer-look-at-bone-health-in-type-1-diabetes-mellitus
#7
Eleanor P Thong, Sarah Catford, Julie Fletcher, Phillip Wong, Peter J Fuller, Helena Teede, Frances Milat
The association between type 1 diabetes mellitus (T1DM) and bone health has garnered interest over the years. Fracture risk is known to be increased in individuals with T1DM, although bone health assessment is not often performed in the clinical setting. We describe the case of a 21-year-old male with longstanding T1DM with multilevel vertebral fractures on imaging, after presenting with acute back pain without apparent trauma. Dual-energy X-ray absorptiometry (DXA) revealed significantly reduced bone mineral density at the lumbar spine and femoral neck...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29768627/tsh-receptor-antibodies-may-prevent-bone-loss-in-pre-and-postmenopausal-women-with-graves-disease-and-graves-orbitopathy
#8
Mira Siderova, Kiril Hristozov, Aleksandra Tsukeva
OBJECTIVE: Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves' orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves' thyrotoxicosis and Graves' orbitopathy (GO). SUBJECTS AND METHODS: Forty seven women with Graves' disease, mean age 55...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766152/undesired-effect-of-excessive-betamethasone-administration-during-pregnancy-a-rare-case
#9
Alireza Mirzaei, Solmaz Piri, Kaveh Gharanizadeh, Mozhdeh Zabihiyeganeh
Background: Postpartum bilateral femoral neck fracture (BFNF) is a rare condition. We here report a case of BFNF due to excessive corticosteroid consumption, twin pregnancy, immobility, and vitamin D deficiency. Case: This is a report of a 32-yr-old woman with bilateral femoral insufficiency fracture five days after emergency cesarean section due to preterm labor, twin pregnancy, and the history of a previous cesarean section at 33 wk. Antenatal repeated courses of betamethasone injections for fetal lung maturity, daily oral use of prednisolone for the history of miscarriage, immobilization, and vitamin D deficiency were the important contributing factors in her past medical history and lab investigations...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29765105/neural-predisposing-factors-of-postoperative-delirium-in-elderly-patients-with-femoral-neck-fracture
#10
Sunghyon Kyeong, Jung Eun Shin, Kyu Hyun Yang, Woo Suk Lee, Tae-Sub Chung, Jae-Jin Kim
Elderly adults are more likely to develop delirium after major surgery, but there is limited knowledge of the vulnerability for postoperative delirium. In this study, we aimed to identify neural predisposing factors for postoperative delirium and develop a prediction model for estimating an individual's probability of postoperative delirium. Among 57 elderly participants with femoral neck fracture, 25 patients developed postoperative delirium and 32 patients did not. We preoperatively obtained data for clinical assessments, anatomical MRI, and resting-state functional MRI...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762165/improved-fracture-prediction-using-different-frax-adjustments-in-hiv-infected-women
#11
Jingyan Yang, Anjali Sharma, Qiuhu Shi, Kathryn Anastos, Mardge H Cohen, Elizabeth T Golub, Deborah Gustafson, Daniel Merenstein, Wendy J Mack, Phyllis C Tien, Jeri Nieves, Michael T Yin
OBJECTIVES: A Fracture risk assessment tool (FRAX®) using clinical risk factors (CRFs) alone underestimates fracture risk in HIV-infected men. Our objective was to determine whether accuracy of FRAX would be improved by considering HIV as a cause of secondary osteoporosis, and further improved with addition of DXA parameters in HIV-infected women. DESIGN: Subgroup analysis of Women's Interagency HIV Study. METHODS: We included 1148 women (900 HIV-infected and 248 uninfected) over age 40 with data to approximate FRAX CRFs and 10-year observational data for incident fragility fractures; 181 (20%) HIV-infected women had DXA data...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29762119/hip-fracture-mortality-differences-between-intertrochanteric-and-femoral-neck-fractures
#12
Nicholas B Frisch, Nolan Wessell, Michael Charters, Alexander Greenstein, Jonathan Shaw, Edward Peterson, S Trent Guthrie
The purpose of this study was to identify the specific risk factors that affect mortality in patients with hip fractures and differentiate mortality-associated factors between intertrochanteric (IT) and femoral neck (FN) fractures. A total of 1538 consecutive patients with hip fractures were treated at the authors' institution between January 2005 and October 2013. Ultimately 858 IT and 479 FN fracture patients were included on the basis of age >60 years with an isolated hip fracture. Mortality rate at 90 days was 12...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#13
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29750848/accelerated-bone-loss-in-older-men-effects-on-bone-microarchitecture-and-strength
#14
J A Cauley, A J Burghardt, S L Harrison, P M Cawthon, A V Schwartz, E Barrett Connor, Kristine E Ensrud, Lisa Langsetmo, S Majumdar, E Orwoll
Accelerated bone loss (ABL) shown on routine dual-energy X-ray absorptiometry (DXA) may be accompanied by microarchitectural changes, increased cortical porosity and lower bone strength. To test this hypothesis, we performed a cross-sectional study and used high resolution peripheral quantitative computed tomography (HR-pQCT) scans (SCANCO, Inc., Switzerland) to measure estimated bone strength and microarchitecture in the distal radius and distal and diaphyseal tibia. We studied 1628 men who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750828/romosozumab-frame-study-a-post-hoc-analysis-of-the-role-of-regional-background-fracture-risk-on-nonvertebral-fracture-outcome
#15
Felicia Cosman, Daria B Crittenden, Serge Ferrari, E Michael Lewiecki, Juan Jaller-Raad, Cristiano Zerbini, Cassandra E Milmont, Paul D Meisner, Cesar Libanati, Andreas Grauer
In the pivotal Fracture Study in Postmenopausal Women with Osteoporosis (FRAME; NCT01575834), 1 year of the bone-forming agent romosozumab significantly reduced new vertebral and clinical fracture risk versus placebo. Nonvertebral fracture risk was not significantly reduced in the overall population, influenced by a low placebo-group fracture rate, observed particularly in the highest-enrolling region of Latin America. In year 1 of FRAME, postmenopausal women with a T-score of -2.5 to -3.5 at the total hip or femoral neck were randomized to subcutaneous romosozumab 210 mg or placebo once monthly for 12 months...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750116/classification-of-osteoporosis-by-artificial-neural-network-based-on-monarch-butterfly-optimisation-algorithm
#16
D Devikanniga, R Joshua Samuel Raj
Osteoporosis is a life threatening disease which commonly affects women mostly after their menopause. It primarily causes mild bone fractures, which on advanced stage leads to the death of an individual. The diagnosis of osteoporosis is done based on bone mineral density (BMD) values obtained through various clinical methods experimented from various skeletal regions. The main objective of the authors' work is to develop a hybrid classifier model that discriminates the osteoporotic patient from healthy person, based on BMD values...
April 2018: Healthcare Technology Letters
https://www.readbyqxmd.com/read/29739257/obtuse-triangle-screw-configuration-for-optimal-internal-fixation-of-femoral-neck-fracture-an-anatomical-analysis
#17
Qiuliang Zhu, Bengong Shi, Bin Xu, Jianfeng Yuan
OBJECTIVES: To identify the optimal screw configuration for internal fixation of femoral neck fractures based on anatomic analysis on radiologic imaging. METHODS: Thirty proximal femurs of 15 adults were constructed by CT. Three femoral neck sections (FNS), the subcapital, medial, and the fundus, were projected on the lateral femoral trochanteric wall. The simulated three screw configurations in the projection of FNS include: two inverted equilateral triangles symmetrized to the axis of the FNS (IET-FNS group) or the coronal axis of the proximal femur (IET-PR group) and an obtuse triangle (OT group)...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29738418/anxiety-levels-predict-fracture-risk-in-postmenopausal-women-assessed-for-osteoporosis
#18
Antonino Catalano, Gabriella Martino, Federica Bellone, Agostino Gaudio, Carmen Lasco, Viviana Langher, Antonino Lasco, Nunziata Morabito
OBJECTIVE: There has been increasing interest in the association of psychiatric disorders with fracture risk. This study aimed at investigating the role of severity of anxiety in bone health. METHODS: Multiple clinical risk factors for fractures, the Fracture Risk Assessment Tool score, the bone mineral density (BMD) at the lumbar spine and femoral neck, Hamilton Anxiety Rating Scale (HAMA) scores, Beck Depression Inventory scores, and the 36-Item Short Form Health Survey (SF-36) scores for evaluation of the quality of life were determined, and x-ray vertebral morphometry was carried out in postmenopausal women referred for osteoporosis...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29736726/high-incidence-of-intraoperative-calcar-fractures-with-the-cementless-cls-spotorno-stem
#19
Carla Timmer, Davey M J M Gerhardt, Enrico de Visser, Marinus de Kleuver, Job L C van Susante
INTRODUCTION: This study reports on the incidence of intraoperative calcar fractures with the cementless Spotorno (CLS) stem, and the potential role of a learning curve and implant positioning is investigated. METHODS: After introduction of the CLS stem, 800 consecutive cementless total hip arthroplasties (THA) were analyzed. The incidence of calcar fracture in the first 400 THA was compared with the second 400 THA, in order to study a potential learning curve effect...
May 7, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29734844/the-effect-of-patient-fracture-and-surgery-on-outcomes-of-high-energy-neck-of-femur-fractures-in-patients-aged-15-50
#20
Wayne Hoskins, Johnny Rayner, Rohan Sheehy, Harry Claireaux, Roger Bingham, Roselyn Santos, Andrew Bucknill, Xavier L Griffin
INTRODUCTION: High-energy femoral neck fractures in young patients can be devastating, with the risk of osteonecrosis, nonunion, malunion and lifelong morbidity. The aim of this study is to define the effects of patient, fracture and surgical factors on the outcome of high-energy femoral neck fractures in patients aged from 15 to 50 years. METHODS: A retrospective review was conducted of high-energy femoral neck fractures in patients aged 15-50 managed surgically at a Level 1 Trauma Centre, using a prospectively recorded trauma database...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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