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Neoadjuvant rectal cancer

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https://www.readbyqxmd.com/read/29665980/quality-of-life-and-anterior-resection-syndrome-after-surgery-for-mid-to-low-rectal-cancer-a-cross-sectional-study
#1
Loris Trenti, Ana Galvez, Sebastiano Biondo, Alejandro Solis, Francesc Vallribera-Valls, Eloy Espin-Basany, Alvaro Garcia-Granero, Esther Kreisler
BACKGROUND: The aim of this study was to analyze the quality of life (QoL), low anterior resection syndrome (LARS) and fecal incontinence after surgery for mid to low rectal cancer and its relationship with the type of surgical procedure performed. METHODS: A cross-sectional cohort survey study of 358 patients operated on for mid to low rectal cancer. Patients were included in three groups: abdominoperineal resection (APR), low mechanical colorectal anastomosis (CRA) and hand-sewn coloanal anastomosis (CAA)...
April 4, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29665665/-risk-factors-for-low-anterior-resection-syndrome
#2
G J Wu, W W Jia, Q An, T Yu, X L Cao, G Xiao
Objective: While low anterior resection avoided a permanent stoma, it might also cause bowel dysfunction which can significantly impact patients' quality of life. The objective of this study was to identify the incidence and risk factors for the development of bowel dysfunction following rectal surgery. Methods: Patients undergoing anterior resection for rectal neoplasm between January 2010 and December 2015 were identified from a rectal cancer database at the Department of Gastrointestinal Surgery, Beijing Hospital...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29663417/technical-note-a-deep-learning-based-auto-segmentation-of-rectal-tumors-in-mr-images
#3
Jiazhou Wang, Jiayu Lu, Gan Qin, Lijun Shen, Yiqun Sun, Hongmei Ying, Zhen Zhang, Weigang Hu
PURPOSE: Manual contouring of gross tumor volumes (GTV) is a crucial and time-consuming process in rectum cancer radiotherapy. This study aims to develop a simple deep learning based auto segmentation algorithm to segment rectal tumors on T2 weighted MR images. MATERIAL AND METHODS: MRI scans (3T, T2-weighted) of 93 patients with locally advanced (cT3-4 and/or cN1-2) rectal cancer treated with neoadjuvant chemoradiotherapy followed by surgery were enrolled in this study...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29663352/prognostic-value-of-pathological-node-status-after-neoadjuvant-radiotherapy-for-rectal-cancer
#4
E Duchalais, T Glyn Mullaney, G M Spears, S R Kelley, K Mathis, W S Harmsen, D W Larson
BACKGROUND: The prognostic value of pathological lymph node status following neoadjuvant radiotherapy (ypN) remains unclear. This study was designed to determine whether ypN status predicted overall survival. METHODS: Patients with locally advanced rectal adenocarcinoma who underwent neoadjuvant long-course radiation between 2005 and 2014 were identified from the National Cancer Data Base, and divided into ypN0, ypN1 and ypN2 groups. The primary outcome was overall survival...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29661620/tolerability-safety-and-outcomes-of-neoadjuvant-chemoradiotherapy-with-capecitabine-for-patients-aged-%C3%A2-70-years-with-locally-advanced-rectal-cancer
#5
Lotte Jacobs, Ellen van der Vlies, Daan Ten Bokkel Huinink, Haiko Bloemendal, Martijn Intven, Anke B Smits, Bas L A M Weusten, Peter D Siersema, Niels van Lelyveld, Maartje Los
INTRODUCTION: In studies of colorectal cancer, the elderly have been frequently underrepresented because comorbid conditions and functional status often lead to study exclusion. For elderly patients with an indication for neoadjuvant chemoradiotherapy (nCRT), physicians usually decide using clinical factors whether nCRT should be offered. The aim of the present retrospective study was to assess the tolerability of nCRT with capecitabine and the surgical outcomes in patients aged ≥ 70 years with locally advanced rectal cancer...
March 8, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29661280/prognostic-value-of-neoadjuvant-treatment-response-in-locally-advanced-rectal-cancer
#6
Yvonne H Sada, Hop S Tran Cao, George J Chang, Avo Artinyan, Benjamin L Musher, Brandon G Smaglo, Nader N Massarweh
BACKGROUND: For locally advanced rectal cancer, response to neoadjuvant radiation has been associated with improved outcomes but has not been well characterized in general practice. The goals of this study were to describe disease response rates after neoadjuvant treatment and to evaluate the association between disease response and survival. MATERIALS AND METHODS: Retrospective cohort study of patients aged 18-80 y with clinical stage II and III rectal adenocarcinoma in the National Cancer Database (2006-2012)...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29650419/comparison-of-pathological-complete-response-rates-after-neoadjuvant-short-course-radiotherapy-or-chemoradiation-followed-by-delayed-surgery-in-locally-advanced-rectal-cancer
#7
Sieske Hoendervangers, Alice M Couwenberg, Martijn P W Intven, Wilhelmina M U van Grevenstein, Helena M Verkooijen
INTRODUCTION: Patients with locally advanced rectal cancer (LARC) who are unfit for chemoradiation (CRT), are often offered short-course radiotherapy followed by delayed surgery (SCRT-delay). This entails a lower radiation dose, no chemotherapy and a shorter treatment period. This may lower their chances for complete tumor response and, as such, organ-sparing approaches. The purpose of this study was to compare the pathological complete response (pCR) rates between neoadjuvant CRT and SCRT-delay in patients with LARC in a nationwide database from the Netherlands...
March 23, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29650416/effect-of-comorbidities-in-stage-ii-iii-colorectal-cancer-patients-treated-with-surgery-and-neoadjuvant-adjuvant-chemotherapy-a-single-center-observational-study
#8
Marina Baretti, Lorenza Rimassa, Nicola Personeni, Laura Giordano, Maria Chiara Tronconi, Tiziana Pressiani, Silvia Bozzarelli, Armando Santoro
BACKGROUND: Comorbidity has a detrimental effect on cancer survival, however, it is difficult to disentangle its direct effect from its influence on treatment choice. In this study we assessed the effect of comorbidity on survival in patients who received standard treatment for resected stage II and III colorectal cancer (CRC). PATIENTS AND METHODS: In total, 230 CRC patients, 68 rectal (29.6%) and 162 colon cancer (70.4%) treated with surgical resection and neoadjuvant/adjuvant chemotherapy from December 2002 to December 2009 at Humanitas Cancer Center were retrospectively reviewed...
March 21, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29644477/the-selective-use-of-radiation-therapy-in-rectal-cancer-patients
#9
REVIEW
Andrew Martella, Christopher Willett, Manisha Palta, Brian Czito
PURPOSE OF REVIEW: Colorectal cancer has a high global incidence, and standard treatment employs a multimodality approach. In addition to cure, minimizing treatment-related toxicity and improving the therapeutic ratio is a common goal. The following article addresses the potential of omitting radiotherapy in select rectal cancer patients. RECENT FINDINGS: Omission of radiotherapy in rectal cancer is analyzed in the context of historical findings, as well as more recent data describing risk stratification of stage II-III disease, surgical optimization, imaging limitations, improvement in systemic chemotherapeutic agents, and contemporary studies evaluating selective omission of radiotherapy...
April 11, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29644427/-gender-specific-differences-of-the-early-postoperative-and-oncosurgical-long-term-outcome-in-rectal-cancer-data-obtained-in-a-prospective-multicenter-observational-study
#10
J Katzenstein, R Steinert, H Ptok, R Otto, I Gastinger, H Lippert, F Meyer
BACKGROUND: Gender-specific aspects have been increasingly considered in clinical medicine, also in oncological surgery. AIM: To analyze gender-specific differences of early postoperative and oncological outcomes after rectal cancer resection based on data obtained in a prospective multicenter observational study. PATIENTS AND METHODS: As part of the multicenter prospective observational study "Quality assurance in primary rectal cancer", data on tumor site, exogenic and endogenic risk factors, neoadjuvant treatment, surgical procedures, tumor stage, intraoperative and postoperative complications of patients with the histological diagnosis of rectal cancer were registered...
April 11, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29622706/-klebsiella-endophthalmitis-as-the-herald-of-occult-colorectal-cancer
#11
Chun Yue Mak, Helena Pui-Yee Sin, Vesta Cheuk-Ki Chan, Alvin Young
A 67-year-old Chinese man presented with acute loss of vision and pain in the left eye with hypopyon in the anterior chamber. The patient was afebrile with no systemic symptoms at presentation. Diagnosis of endogenous endophthalmitis was made with vitreous tap yielding Klebsiella pneumoniae Pars plana vitrectomy was performed twice to clear the infection. Thorough investigations showed no septic foci. Whole body positron emission tomography CT revealed a rectal tumour and biopsy showed adenocarcinoma. He was treated with neoadjuvant chemoirradiation followed by surgery to resect the tumour...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29615840/biomarker-expression-in-rectal-cancer-tissue-before-and-after-neoadjuvant-therapy
#12
Leonora Sf Boogerd, Maxime Jm van der Valk, Martin C Boonstra, Hendrica Ajm Prevoo, Denise E Hilling, Cornelis Jh van de Velde, Cornelis Fm Sier, Arantza Fariña Sarasqueta, Alexander L Vahrmeijer
Purpose: Intraoperative identification of rectal cancer (RC) can be challenging, especially because of fibrosis after treatment with preoperative chemo- and radiotherapy (CRT). Tumor-targeted fluorescence imaging can enhance the contrast between tumor and normal tissue during surgery. Promising targets for RC imaging are carcinoembryonic antigen (CEA), epithelial cell adhesion molecule (EpCAM) and the tyrosine-kinase receptor Met (c-Met). The effect of CRT on their expression determines their applicability for imaging...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29605024/benchmarking-rectal-cancer-care-institutional-compliance-with-a-longitudinal-checklist
#13
William C Chapman, Pamela Choi, Alexander T Hawkins, Steven R Hunt, Matthew L Silviera, Paul E Wise, Matthew G Mutch, Sean C Glasgow
BACKGROUND: In 2012, the American Society of Colon and Rectal Surgeons published the Rectal Cancer Surgery Checklist, a consensus document listing 25 essential elements of care for all patients undergoing radical surgery for rectal cancer. The authors herein examine checklist adherence in a mature, multisurgeon specialty academic practice. MATERIALS AND METHODS: A retrospective medical record review of patients undergoing elective radical resection for rectal adenocarcinoma over a 23-mo period was conducted...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29602976/do-clinical-criteria-reflect-pathologic-complete-response-in-rectal-cancer-following-neoadjuvant-therapy
#14
Aurelie Garant, Livia Florianova, Adrian Gologan, Alan Spatz, Julio Faria, Nancy Morin, Carol-Ann Vasilevsky, Te Vuong
BACKGROUND: Clinical complete response (cCR) in rectal cancer is being evaluated as a tool to identify patients who would not require surgery in the curative management of rectal cancer. Our study reviews mucosal changes after neoadjuvant therapy for rectal cancer in patients treated at our center. METHODS: Pathology reports were retrieved for patients treated with neoadjuvant chemoradiation therapy (CRT) or high-dose rate brachytherapy (HDRBT). The macroscopic appearance of the specimen was compared with pathologic staging...
March 30, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29594202/time-to-surgery-and-pathologic-complete-response-after-neoadjuvant-chemoradiation-in-rectal-cancer-a-population-study-on-2094-patients
#15
Gabriella Macchia, Maria Antonietta Gambacorta, Carlotta Masciocchi, Giuditta Chiloiro, Giovanna Mantello, Maika di Benedetto, Marco Lupattelli, Elisa Palazzari, Liliana Belgioia, Almalina Bacigalupo, Aldo Sainato, Sabrina Montrone, Lucia Turri, Angela Caroli, Antonino De Paoli, Fabio Matrone, Carlo Capirci, Giampaolo Montesi, Rita Marina Niespolo, Mattia Falchetto Osti, Luciana Caravatta, Alessandra Galardi, Domenico Genovesi, Maria Elena Rosetto, Caterina Boso, Piera Sciacero, Lucia Giaccherini, Salvatore Parisi, Antonella Fontana, Francesco Romeo Filippone, Vincenzo Picardi, Alessio Giuseppe Morganti, Vincenzo Valentini
Background: To retrospectively evaluate the difference in terms of pathologic complete response (pCR) according to time elapsed between chemoradiation (CRT) and total mesorectal excision (TME) on a large unselected real-life dataset of locally advanced rectal cancer (LARC) patients. Methods: A multicentre retrospective cohort study of LARC patients from 21 Italian Radiotherapy Institutions was performed. Patients were stratified into 3 different time intervals from CRT...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29594111/waiting-time-following-neoadjuvant-chemoradiotherapy-for-rectal-cancer-does-it-really-matter
#16
Aris Plastiras, Michail Sideris, Andy Gaya, Amyn Haji, Joseph Nunoo-Mensah, Asif Haq, Savvas Papagrigoriadis
Background: Neoadjuvant chemoradiotherapy (CRT) is considered the standard approach before any surgical intervention for locally advanced rectal tumors and has been proven to significantly improve the local recurrence rates of rectal cancer. However, the optimal timing of surgical resection after neoadjuvant CRT remains debatable. Objective and Methods: We conducted a retrospective review of 65 consecutive patients with locally advanced rectal cancer who underwent preoperative CRT followed by surgical resection in order to evaluate the optimal time for surgical treatment...
February 2018: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/29593430/prospective-study-of-neoadjuvant-chemoradiotherapy-using-intensity-modulated-radiotherapy-and-5-fluorouracil-for-locally-advanced-rectal-cancer-toxicities-and-response-assessment
#17
David K Simson, Swarupa Mitra, Parveen Ahlawat, Upasna Saxena, Manoj Kumar Sharma, Sheh Rawat, Harpreet Singh, Babita Bansal, Lalitha Kameshwari Sripathi, Aditi Tanwar
Aims and objectives: The past 2 decades witnessed the strengthening of evidence favoring the role of neoadjuvant chemoradiation (CHRT) in the treatment of locally advanced rectal cancer. The study aims to evaluate the response and acute toxicities to neoadjuvant CHRT using intensity-modulated radiotherapy (IMRT) in the treatment of rectal cancer. Predictive factors to achieve pathological complete response (pCR) were analyzed, as a secondary endpoint. Materials and methods: All consecutive patients who underwent IMRT as part of neoadjuvant CHRT in the treatment of rectal cancer between August 2014 and December 2016 at a tertiary cancer care center were accrued for the study...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29587797/comparison-of-efficacy-and-safety-of-preoperative-chemoradiotherapy-in-locally-advanced-upper-and-middle-lower-rectal-cancer
#18
Ming-Yii Huang, Hsin-Hua Lee, Hsiang-Lin Tsai, Ching-Wen Huang, Yung-Sung Yeh, Cheng-Jen Ma, Chun-Ming Huang, Chiao-Yun Chen, Joh-Jong Huang, Jaw-Yuan Wang
BACKGROUND: We aimed to explore the efficacy and safety profile of preoperative neoadjuvant chemoradiation (NACRT) in locally advanced rectal cancer (LARC) in upper rectum versus middle/lower rectum. METHODS: The study included 173 patients with stage II or III (T2-4b, N0-2b) LARC who underwent NACRT followed by total mesorectal excision (TME) between January 2011 and October 2016. Cox regression, log-rank test, and Kaplan-Meier curves were calculated. RESULTS: Among the 173 patients, 58 had lesions in the upper rectum and 115 patients had lesions in middle/lower rectum...
March 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29581756/the-optimal-application-of-transrectal-ultrasound-in-staging-of-rectal-cancer-following-neoadjuvant-therapy-a-pragmatic-study-for-accuracy-investigation
#19
Yufeng Ren, Jinning Ye, Yan Wang, Weixin Xiong, Jianbo Xu, Yulong He, Shirong Cai, Min Tan, Yujie Yuan
Background: Transrectal ultrasound (TRUS) is a cost-effective test for preoperative assessment of rectal cancer. However, whether the accuracy of TRUS staging is correlated with tumor location remains obscured. This study is designed to explore their relationship and confirm an optimal application of TRUS in rectal cancer restaging. Methods: From 2005 to 2011, rectal cancer patients with TRUS data were retrospectively reviewed. Patients were divided into five groups according to tumor-involved rectal segment (SEG) above the anal verge: SEG I 1-3cm, II 3-6cm, III 6-9cm, IV 9-12cm, and V 12-16cm...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29578178/comparison-of-short-course-with-long-course-preoperative-neoadjuvant-therapy-for-rectal-cancer-a-meta-analysis
#20
Ke Chen, Guoming Xie, Qi Zhang, Yanping Shen, Taoqi Zhou
Aim: This study attempted to compare the prognostic performance of short- and long-course preoperative treatments for neoadjuvant therapy of rectal cancer by meta-analysis. Methods: Electronic databases of PubMed and Embase were searched for eligible studies updated to February 29, 2016. Studies were included based on several predefined inclusion criteria. Quality assessment was carried out according to the Cochrane Collaboration recommendations in Cochrane handbook...
2018: Journal of Cancer Research and Therapeutics
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