Marinde J G Bond, Karen Bolhuis, Olaf J L Loosveld, Jan Willem B de Groot, Helga Droogendijk, Helgi H Helgason, Mathijs P Hendriks, Joost M Klaase, Geert Kazemier, Mike S L Liem, Arjen M Rijken, Cornelis Verhoef, Johannes H W de Wilt, Koert P de Jong, Michael F Gerhards, Martinus J van Amerongen, Marc R W Engelbrecht, Krijn P van Lienden, I Quintus Molenaar, Bart de Valk, Brigitte C M Haberkorn, Emile D Kerver, Frans Erdkamp, Robbert J van Alphen, Daniëlle Mathijssen-van Stein, Aysun Komurcu, Marta Lopez-Yurda, Rutger-Jan Swijnenburg, Cornelis J A Punt
BACKGROUND: Patients with initially unresectable colorectal cancer liver metastases might qualify for local treatment with curative intent after reducing the tumour size by induction systemic treatment. We aimed to compare the currently most active induction regimens. METHODS: In this open-label, multicentre, randomised, phase 3 study (CAIRO5), patients aged 18 years or older with histologically confirmed colorectal cancer, known RAS/BRAFV600E mutation status, WHO performance status of 0-1, and initially unresectable colorectal cancer liver metastases were enrolled at 46 Dutch and one Belgian secondary and tertiary centres...
July 2023: Lancet Oncology