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https://www.readbyqxmd.com/read/29679775/influence-of-side-effects-on-early-therapy-persistence-with-letrozole-in-post-menopausal-patients-with-early-breast-cancer-results-of-the-prospective-evaluate-tm-study
#1
N Nabieva, T Fehm, L Häberle, J de Waal, M Rezai, B Baier, G Baake, H-C Kolberg, M Guggenberger, M Warm, N Harbeck, R Wuerstlein, J-U Deuker, P Dall, B Richter, G Wachsmann, C Brucker, J W Siebers, M Popovic, T Kuhn, C Wolf, H-W Vollert, G-P Breitbach, W Janni, R Landthaler, A Kohls, D Rezek, T Noesselt, G Fischer, S Henschen, T Praetz, V Heyl, T Kühn, T Krauss, C Thomssen, A Hohn, H Tesch, C Mundhenke, A Hein, C C Hack, K Schmidt, E Belleville, S Y Brucker, S Kümmel, M W Beckmann, D Wallwiener, P Hadji, P A Fasching
BACKGROUND: Endocrine treatment (ET) with an aromatase inhibitor (AI) is the treatment of choice in post-menopausal patients with hormone receptor-positive early breast cancer (EBC). However, adverse events (AEs) often lead to treatment discontinuation. This analysis aimed to identify side-effects that lead to patients failing to persist with letrozole treatment. PATIENTS AND METHODS: Post-menopausal hormone receptor-positive EBC patients starting ET with letrozole were enroled in EvAluate-TM, a non-interventional study...
April 18, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29677538/improvement-effects-of-a-mixed-extract-of-flowers-of-pueraria-thomsonii-benth-and-peels-of-citrus-unshiu-markovich-on-postmenopausal-symptoms-of-ovariectomized-mice
#2
Na-Ra Han, Sun-Young Nam, Sungwei Hong, Hee-Yun Kim, Phil-Dong Moon, Hyeong-Jin Kim, Hosong Cho, Boyoung Lee, Hyung-Min Kim, Hyun-Ja Jeong
BACKGROUND: Menopausal hot flushes occur frequently in postmenopausal women. In the present study, we investigated a regulatory effect of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich (PCE17), an extract of flowers of Pueraria thomsonii Benth. (PE), an extract of peels of Citrus unshiu Markovich (CE), a mixture of tectorigenin 7-O-xylosylglucoside, tectoridin, and tectorigenin (Tec, the active compounds of PE), and hesperidin (Hes, an active compound of CE) on menopausal hot flushes...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676942/pharmacotherapy-for-schizophrenia-in-postmenopausal-women
#3
Alexandre González-Rodríguez, Mary V Seeman
Reduced estrogen levels at menopause mean a loss of the neuroprotection that is conferred, from puberty until menopause, on women with schizophrenia. The postmenopausal stage of schizophrenia requires therapeutic attention because women with this diagnosis almost invariably experience increased symptoms and increased side effects at this time. So far, few targeted therapies have been successfully developed. Areas covered: This non-systematic, narrative review is based on the relevant published literature indexed in PubMed...
April 20, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29673835/effects-of-ovarian-reserve-and-hormone-therapy-on-hearing-in-premenopausal-and-postmenopausal-women-a-cross-sectional-study
#4
Jingfei Zhang, Tingyue Zhang, Lisheng Yu, Qianying Ruan, Lingxue Yin, Dong Liu, Haicheng Zhang, Wenpei Bai, Zhenghong Ren
OBJECTIVES: To observe the hearing function around menopause, to analyze the effects of ovarian reserve and hormone therapy on hearing, and to study factors related to hearing loss among women around menopause. STUDY DESIGN: In this cross-sectional study, we evaluated 109 women around menopause aged 45-55 years, including 40 women with ovarian failure, 48 with ovarian non-failure, and 21 receiving hormone therapy. All women underwent an audiologic evaluation, and hormone blood testing was performed...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673834/severity-and-duration-of-menopausal-symptoms-after-risk-reducing-salpingo-oophorectomy
#5
A Stuursma, C M G van Driel, N J Wessels, G H de Bock, M J E Mourits
OBJECTIVES: To reduce the risk of ovarian cancer, women with BRCA1/2 mutations are advised to undergo risk-reducing salpingo-oophorectomy (RRSO) at a premenopausal age. Premenopausal RRSO results in acute menopause and is associated with various menopausal symptoms. This study investigates the severity and duration of subjective menopausal symptoms after premenopausal RRSO and associated factors. METHODS: We included 199 women who had undergone RRSO before age 52 in this cross-sectional study...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673828/decision-making-for-the-treatment-of-climacteric-symptoms-using-the-menopause-rating-scale
#6
Juan Enrique Blümel, Eugenio Arteaga, Joaquín Parra, Carolina Monsalve, Valentina Reyes, María Soledad Vallejo, Rosa Chea
OBJECTIVE: The Menopause Rating Scale (MRS) is one of the most frequently used instruments to evaluate menopausal symptoms; however, no cut-off score is given that would indicate the need for treatment. Our goal was to determine such a cut-off score on the MRS, using as a standard a woman's own perception of her need for treatment in relation to the severity of her symptoms. MATERIAL AND METHODS: The sample comprised 427 healthy women aged 40-59 years who were not taking hormonal treatment...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29668349/climacteric-women-at-work-what-lurks-behind-poor-occupational-quality-of-life
#7
Tatjana Gazibara, Biljana Rancic, Sanja Radovanovic, Ilma Kurtagic, Selmina Nurkovic, Nikolina Kovacevic, Jelena Dotlic
Physical and psychological changes during menopausal transition may affect various aspects of everyday functioning including women's work ability and work productivity. Presence of menopausal symptoms has been well-acknowledged to negatively affect quality of life (QOL). However, data on factors associated with occupational QOL among women at this period of life are lacking. The authors' purpose in this study was to evaluate factors affecting occupational QOL in a sample of employed mid-life women who are experiencing menopause...
April 18, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29667744/intraurethral-erbium-yag-laser-for-the-management-of-urinary-symptoms-of-genitourinary-syndrome-of-menopause-a-pilot-study
#8
Adrian Gaspar, Sandra Maestri, Joaquin Silva, Hugo Brandi, Daniel Luque, Neža Koron, Zdenko Vižintin
OBJECTIVES: Genitourinary syndrome of menopause (GSM) combines the conditions of vulvovaginal atrophy (VVA) and urinary tract dysfunction, which is a result of urethral atrophy. There are several treatment methods available for the management of vulvovaginal symptoms of GSM, whereas urinary tract dysfunction often remains overlooked and undertreated. The objective of this pilot study was to assess the safety and efficacy of intraurethral Er:YAG laser treatment of urinary symptoms of GSM...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29649395/top-10-tips-palliative-care-clinicians-should-know-when-caring-for-patients-with-endometrial-cancer
#9
Brittany A Davidson, Haley A Moss, Jaclyn Arquiette, Arif H Kamal
Endometrial cancer incidence has been increasing over the last two decades, likely due to the obesity epidemic. The majority of these cancers are confined to the uterus at diagnosis and can be cured with surgery. Overall, five-year disease-specific survival is about 80%, but some patients have locally advanced or metastatic disease that is not amenable to control with radiation and/or chemotherapy. Disease-related symptoms are most common in this subset of patients with endometrial cancer, although women with early-stage disease may also experience side effects related to surgical menopause or adjuvant treatment...
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29648860/motivation-and-readiness-for-tobacco-cessation-among-nicotine-dependent-postmenopausal-females-a-pilot-study
#10
MacKenzie R Peltier, Melanie R Roys, Aaron F Waters, Christine Vinci, Krystal M Waldo, Shelby A Stewart, Robert C Toups, Louis Jones, Amy L Copeland
Despite considerable health risks due to lower levels of estrogen production and the compounding antiestrogenic effects of nicotine, postmenopausal females continue to smoke. These females face significant barriers to cessation, including negative affect, weight concerns, and menopausal symptom severity. The current pilot study explored the effect of negative affect, weight concerns, and menopausal symptom severity on motivation and readiness to quit smoking. Eighteen postmenopausal smokers were randomized to receive brief motivational interviewing (B-MI; n = 8) or control treatment (i...
April 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29628723/prevalence-of-postmenopausal-symptoms-its-effect-on-quality-of-life-and-coping-in-rural-couple
#11
Radha Shukla, Jaishree Ganjiwale, Rakhee Patel
Aim: Menopause is a physiological process, with potential to lead to various pathological/psychological complications, leading to change in quality of life (QOL). Although literature suggests the effect of menopause on various aspects of life, there is scarcity of studies from rural setup in this regard. Thus, it is essential to assess extent of menopause-related changes, its awareness, and coping mechanisms in rural couple. This study aimed to find the prevalence of postmenopausal symptoms, its severity, and effect on QOL of rural women and the couples' coping mechanisms...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29628218/effects-of-sex-hormones-and-age-on-brain-volume-in-post-menopausal-women
#12
Gwang-Won Kim, Kwangsung Park, Gwang-Woo Jeong
BACKGROUND: Investigation of the effect of sex hormones on the brain volume in women provides a unique opportunity to examine menopause-related morphometric alterations. AIM: To evaluate brain morphological alterations in post-menopausal women using voxel-based morphometry and its correlations with sex hormone levels. METHODS: 20 Pre-menopausal women and 20 post-menopausal women underwent structural MRI. OUTCOMES: T1-weighted magnetic resonance data were acquired and serum sex hormones including total estrogen, estriol, estradiol (E2), follicle-stimulating hormone, free testosterone, SHBG, and luteinizing hormone were measured...
April 5, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29623928/effect-of-tibolone-pretreatment-on-kinases-and-phosphatases-that-regulate-the-expression-and-phosphorylation-of-tau-in-the-hippocampus-of-rats-exposed-to-ozone
#13
Rodolfo Pinto-Almazan, Julia J Segura-Uribe, Marvin A Soriano-Ursúa, Eunice D Farfán-García, Juan M Gallardo, Christian Guerra-Araiza
Oxidative stress (OS) is a key process in the development of many neurodegenerative diseases, memory disorders, and other pathological processes related to aging. Tibolone (TIB), a synthetic hormone used as a treatment for menopausal symptoms, decreases lipoperoxidation levels, prevents memory impairment and learning disability caused by ozone (O3 ) exposure. However, it is not clear if TIB could prevent the increase in phosphorylation induced by oxidative stress of the microtubule-associated protein Tau. In this study, the effects of TIB at different times of administration on the phosphorylation of Tau, the activation of glycogen synthase kinase-3β (GSK3β), and the inactivation of Akt and phosphatases PP2A and PTEN induced by O3 exposure were assessed in adult male Wistar rats...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29622056/psychosocial-and-health-related-risk-factors-for-depressive-symptom-trajectories-among-midlife-women-over-15-years-study-of-women-s-health-across-the-nation-swan
#14
Joyce T Bromberger, Laura L Schott, Nancy E Avis, Sybil L Crawford, Sioban D Harlow, Hadine Joffe, Howard M Kravitz, Karen A Matthews
BACKGROUND: Psychosocial and health-related risk factors for depressive symptoms are known. It is unclear if these are associated with depressive symptom patterns over time. We identified trajectories of depressive symptoms and their risk factors among midlife women followed over 15 years. METHODS: Participants were 3300 multiracial/ethnic women enrolled in a multisite longitudinal menopause and aging study, Study of Women's Health Across the Nation. Biological, psychosocial, and depressive symptom data were collected approximately annually...
April 6, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29619387/a-comparative-study-on-the-effect-of-black-cohosh-and-evening-primrose-oil-on-menopausal-hot-flashes
#15
Maryam Mehrpooya, Soghra Rabiee, Amir Larki-Harchegani, Amir-Mohammad Fallahian, Abbas Moradi, Sara Ataei, Masoumeh Taravati Javad
INTRODUCTION: Hot flashes are considered to be a common experience for menopausal women and they can compromise the quality of life. The objective of this study is to assess the efficacy of Cimicifuga racemosa in comparison with evening primrose oil (EPO) in postmenopausal women with menopause-related symptoms. MATERIALS AND METHODS: This study was performed on 80 postmenopausal women with hot flashes. The participants were randomly divided into two groups by blocked randomization...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29613885/hormone-therapy-in-menopausal-women-with-fibroids-is-it-safe
#16
Vedhapriya Srinivasan, Mark G Martens
Menopause is an important transition in the life of women. It has been estimated that by the year 2030, worldwide 1.2 billion women will be menopausal. The most bothersome symptoms of menopause are believed to be due to declines in estrogen levels in postmenopausal women. Thus, hormone therapy is an effective treatment option for menopausal women, although prolonged use of hormone therapy is associated with a slightly increased risk of breast cancer, thromboembolism, and stroke. A literature search for studies evaluating the effects of hormone therapy in menopausal women with asymptomatic fibroids demonstrated variable effects of hormone therapy on the volume and size of the fibroids...
April 2, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29609503/postmenopausal-endometriosis-drawing-a-clearer-clinical-picture
#17
D A Tan, M J G Almaria
This review aims to draw a clearer clinical picture of postmenopausal endometriosis. Based on limited literature, postmenopausal endometriosis emerges as an infrequent entity but with a clinical picture significantly unlike that of premenopausal endometriosis. In contrast to the premenopausal disease, postmenopausal endometriosis occurs in a state of ovarian estrogen deficiency, appears to have a greater predisposition to malignant change, may have a greater tendency to spread to extragonadal organs and develop into constrictive and/or obstructive lesions, and is preferably treated surgically...
April 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29609500/an-unusual-hazard-of-menopause-in-the-workplace-a-case-report
#18
B G A Stuckey, M S Stuckey
Untreated vasomotor symptoms of the menopause can have a major impact on women at work. Recent recommendations advocate modification of the working environment, including adequate air-conditioning, to help relieve these symptoms. However, this may cause discomfort for work colleagues. We report the case of a 40-year-old woman with cold urticaria. Cold urticaria is a serious, potentially life-threatening condition. Our patient's symptoms were exacerbated when her postmenopausal work colleagues turned the air-conditioner temperature down to relieve their vasomotor symptoms...
April 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29606085/racial-ethnic-differences-in-cognitive-symptoms-during-the-menopausal-transition
#19
Eun-Ok Im, Yun Hu, Ching-Yu Cheng, Young Ko, Eunice Chee, Wonshik Chee
The purpose of this study was to explore racial/ethnic differences in midlife women's cognitive symptoms among four major racial/ethnic groups in the United States and to determine multiple factors that influenced the women's cognitive symptoms. This was a secondary analysis of the data from two larger studies among 1,054 midlife women. The instruments included multiple questions on background characteristics and health and menopausal status, and the Cognitive Symptom Index for Midlife Women. The data were analyzed using multiple logistic and Poisson regression analyses...
March 1, 2018: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29603811/utility-of-catheterized-specimens-in-reducing-overdiagnosis-of-urinary-tract-infections-in-women
#20
Carrie M Aisen, Erica Ditkoff, Arindam RoyChoudhury, Michele Corish, Matthew P Rutman, Doreen E Chung, Gina M Badalato, Kimberly L Cooper
AIMS: To evaluate the utility of catheterized samples in reducing overdiagnosis of UTI based on voided specimens among patients presenting with a range of urinary symptoms. We also aimed to determine variables that may modify the predictive value of the voided midstream urine culture. METHODS: Patient charts were reviewed to identify female patients referred to our voiding dysfunction clinic with a range of complaints warranting urine studies (5/2014-8/2016). Patients with a positive voided urine culture who also had a catheterized urine culture in our system were included...
March 31, 2018: Neurourology and Urodynamics
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