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Treatment resitant depression

Resit Canbeyli
Depression involves a dysfunction in an affective fronto-limbic circuitry including the prefrontal cortices, several limbic structures including the cingulate cortex, the amygdala, and the hippocampus as well as the basal ganglia. A major emphasis of research on the etiology and treatment of mood disorders has been to assess the impact of centrally generated (top-down) processes impacting the affective fronto-limbic circuitry. The present review shows that peripheral (bottom-up) unipolar stimulation via the visual and the auditory modalities as well as by physical exercise modulates mood and depressive symptoms in humans and animals and activates the same central affective neurocircuitry involved in depression...
2013: Frontiers in Human Neuroscience
Ajda Yilmaz, Ayla Aksoy, Resit Canbeyli
The present experiment investigated the potentially ameliorative effect of exposure to light in the dark phase of an 12:12 h daily lighting schedule (12L/12D cycle) on behavioral despair, an animal model of depression based on two forced swim tests separated by 24 h. Experimental groups of female Wistar rats were maintained on the 12L/12D cycle except for a single exposure to 12 h of light treatment in the dark phase of the 12L/12D cycle. Control animals were treated similarly except for light treatment. Animals then underwent one of two sets of behavioral tests starting on either the day light (or control) treatment ended (No Delay groups) or 24 h thereafter (Delay groups)...
December 2004: Progress in Neuro-psychopharmacology & Biological Psychiatry
Sevda Bulduk, Resit Canbeyli
The present experiment investigated the potentially differential effects of presenting inescapable tones with progressively increasing or decreasing durations on performance in behavioral despair, an animal model of depression based on two forced swim tests. Groups of female Wistar rats (n=8 each) were exposed to 60 inescapable tones (2000 Hz, 120 dB) either in a series of increasing or decreasing durations. Duration of tone exposure was incrementally increased (from 1 to 10 s) or decreased (from 10 to 1 s) by 1 s every six trials...
May 2004: Progress in Neuro-psychopharmacology & Biological Psychiatry
Ozgür Tataroğlu, Ayla Aksoy, Ajda Yilmaz, Resit Canbeyli
The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN disrupt both the rhythms and the basal levels of the HPA axis hormones involved in coping with stress. Moreover, stress can affect the biological rhythms regulated by the SCN, and disruption of biological rhythms in turn can cause stress...
March 19, 2004: Brain Research
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