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Follistatin

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https://www.readbyqxmd.com/read/29159199/dna-mediated-gene-therapy-in-a-mouse-model-of-limb-girdle-muscular-dystrophy-2b
#1
Julia Ma, Christophe Pichavant, Haley du Bois, Mital Bhakta, Michele P Calos
Mutations in the gene for dysferlin cause a degenerative disorder of skeletal muscle known as limb girdle muscular dystrophy 2B. To achieve gene delivery of plasmids encoding dysferlin to hind limb muscles of dysferlin knockout mice, we used a vascular injection method that perfused naked plasmid DNA into all major muscle groups of the hind limb. We monitored delivery by luciferase live imaging and western blot, confirming strong dysferlin expression that persisted over the 3-month time course of the experiment...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29156385/interaction-with-the-gdf8-11-pathway-reveals-treatment-options-for-adenocarcinoma-of-the-breast
#2
Christoph Wallner, Marius Drysch, Mustafa Becerikli, Henriette Jaurich, Johannes Maximilian Wagner, Stephanie Dittfeld, Julia Nagler, Kamran Harati, Mehran Dadras, Stathis Philippou, Marcus Lehnhardt, Björn Behr
Breast adenocarcinoma continues to be the most frequently diagnosed tumor entity. Despite established therapy options, mortality for breast cancer remains to be as high as 40,000 patients in the US annually. Thus, a need to develop a patient-oriented, targeted therapy exists. In this study, we investigated the interaction of breast adenocarcinoma with the ubiquitously present protein Follistatin and subsequently the GDF8/11 pathway. We analyzed primary histological samples from adenocarcinoma patients for expression of Follistatin and GDF8/11...
November 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29149247/quantitative-proteomic-profiling-of-bovine-follicular-fluid-during-follicle-development
#3
Rodrigo de Andrade Ferrazza, Elizabeth Moreira Dos Santos Schmidt, Monika Mihm Carmichael, Fabiana Ferreira de Souza, Richard Burchmore, Roberto Sartori, Peter David Eckersall, João Carlos Pinheiro Ferreira
Bovine follicular fluid (FF) constitutes the microenvironment of follicles and includes various biologically active proteins. We performed a study involving 18 healthy non-lactating Holstein cows to determine the protein expression profile of FF at key-stages of follicular development. Follicles were individually aspirated in vivo at pre-deviation (F1∼7.0mm); deviation (F1∼8.5mm); post-deviation (F1∼12.0mm); and pre-ovulatory stages of follicle development, which were confirmed by measurement of follicular estradiol and progesterone concentrations...
November 15, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29135371/follistatin-like-protein-1-upregulates-dendritic-cell-based-immunity-in-patients-with-nasopharyngeal-carcinoma
#4
Hong Wang, Shiping Huang, Senyong Wu, Shaolin Yin, Anzhou Tang, Wensheng Wen
Follistatin-like protein-1 (FSTL1) is an inflammatory factor that can induce an inflammatory response and is expressed in cancers. However, little is known about its content and function in nasopharyngeal carcinoma (NPC). Interleukin (IL)-12 and IL-4 are primarily secreted by dendritic cells (DCs) and activated T lymphocytes, respectively; these factors can induce Th cell differentiation and cytotoxic lymphocyte production, both of which facilitate tumors through the STAT4 and STAT6 pathways, respectively. In this study, the relationship between FSTL1 and both IL-12 and IL-4 as well as the functional mechanism of these cytokines was explored...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29134682/differential-effects-of-follistatin-on-porcine-oocyte-competence-and-cumulus-cell-gene-expression-in-vitro
#5
Z Guo, M S Islam, D Liu, G Liu, L Lv, Y Yang, B Fu, L Wang, Z Liu, H He, H Wu
Several oocyte-derived genes/proteins are essential to early embryonic development. The expression and stability of these proteins are influenced by the autocrine/paracrine activity of factors released by oocytes and cumulus cells. This study investigated the paracrine and autocrine activity of follistatin (FS), which is secreted by oocytes and cumulus cells as part of porcine embryogenesis. Immunohistochemical (IHC) localization of follistatin was conducted on 100 randomly selected early- and late-cleaving two-cell embryos...
November 14, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29126163/identification-of-novel-cancer-biomarkers-of-prognostic-value-using-specific-gene-regulatory-networks-grn-a-novel-role-of-rad51ap1-for-ovarian-and-lung-cancers
#6
Dimple Chudasama, Valeria Bo, Marcia Hall, Vladimir Anikin, Jeyarooban Jeyaneethi, Jane Gregory, George Pados, Allan Tucker, Amanda Harvey, Ryan Pink, Emmanouil Karteris
To date, microarray analyses have led to the discovery of numerous individual "molecular signatures" associated with specific cancers. However, there are serious limitations for the adoption of these multi-gene signatures in the clinical environment for diagnostic or prognostic testing as studies with more power need to be carried out. This may involve larger richer cohorts and more advanced analyses.In this study, we conduct analyses -based on GRN- to reveal distinct and common biomarkers across cancer types...
November 8, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29123487/hypertrophy-stimulation-at-the-onset-of-type-i-diabetes-maintains-the-soleus-but-not-the-edl-muscle-mass-in-wistar-rats
#7
Marco A S Fortes, Maria V M Scervino, Gabriel N Marzuca-Nassr, Kaio F Vitzel, Carlos H da Justa Pinheiro, Rui Curi
Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated in Wistar rats. The purpose was to examine whether the overload-induced hypertrophy can counteract the hypotrophy associated to the diabetic state. The experiments were performed in oxidative (soleus) or glycolytic (EDL) muscles...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29119699/effect-of-follistatin-on-pre-implantational-development-of-pig-parthenogenetic-embryos
#8
Yunsheng Li, Xing Liu, Zhen Chen, Dandan Song, Jie Yang, Xiaoyuan Zuo, Zubing Cao, Ya Liu, Yunhai Zhang
The present study was designed to explore effects of follistatin (FST) on pre-implantational development of parthenogenetically activated embryos (PAEs) in pigs. First, we investigated the FST messenger RNA expression level and dynamic FST protein expression patterns in porcine oocytes and PAEs. Then, PAEs were placed in embryo culture medium supplemented with 10 ng/mL of FST-288, FST-300, and FST-315. Next, PAEs were cultured with 0, 1, 10 and 100 ng/mL of FST-315 protein throughout the in vitro culture (IVC) duration...
November 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29115636/fstl1-suppresses-tumor-cell-proliferation-invasion-and-survival-in-non-small-cell-lung-cancer
#9
Xiaolei Ni, Xiaoming Cao, Yongquan Wu, Jian Wu
Follistatin like-1 (FSTL1) is a secreted glycoprotein involved in a series of physiological and pathological processes. However, its contribution to the development of cancer, especially the pathogenesis of NSCLC, remains to be elucidated. We explored the expression, function, and molecular mechanism of FSTL1 in NSCLC. In this study, we detected the expression of FSTL1 in a panel of NSCLC cell lines and lung normal epithelial cell line by qRT-PCR and western blot analysis and found that FSTL1 was downregulated in NSCLC cells compared with normal control...
October 31, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29113826/ghrelin-suppresses-cardiac-fibrosis-of-post-myocardial-infarction-heart-failure-rats-by-adjusting-the-activin-a-follistatin-imbalance
#10
Chunyan Yang, Jinsha Liu, Kai Liu, Beibei Du, Kaiyao Shi, Mei Ding, Bing Li, Ping Yang
Ghrelin, a growth hormone-releasing peptide, potentially improves cardiac function, but the mechanisms remain unclear. In the study, the rat heart failure (HF) model was established by ligating the left anterior descending coronary artery (LAD) and treated with ghrelin (100μg/kg, subcutaneous injection, bid); neonatal rat cardiomyocytes were cultured and stimulated with Ang II (0.1μM) and ghrelin(0.1μM) to explore the underlying mechanism of ghrelin in myocardial remodeling. Hemodynamic changes and serum brain natriuretic peptide (BNP) concentrations were measured to assess cardiac function...
November 4, 2017: Peptides
https://www.readbyqxmd.com/read/29111388/activin-over-expression-in-the-testis-of-mice-lacking-the-inhibin-%C3%AE-subunit-gene-is-associated-with-androgen-deficiency-and-regression-of-the-male-reproductive-tract
#11
Rukmali Wijayarathna, David M de Kretser, Andreas Meinhardt, Ralf Middendorff, Helen Ludlow, Nigel P Groome, Kate A Loveland, Mark P Hedger
Regionalised interaction of the activins, follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin α-subunit (Inha(-/-)). Serum and intratesticular activin B, although not activin A and follistatin, were increased in Inha(-/-) mice at 25 days of age, but all three proteins were elevated at 56 days. None of these proteins were altered within the epididymis and vas deferens at either age. At 25 days, histology of the epididymis and vas deferens was similar to wild-type...
October 27, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29111087/angiogenic-factor-screening-in-women-with-mild-preeclampsia-new-and-significant-proteins-in-plasma
#12
Karol Charkiewicz, Elwira Jasinska, Joanna Goscik, Ewa Koc-Zorawska, Marcin Zorawski, Pawel Kuc, Grzegorz Raba, Tomasz Kluz, Jaroslaw Kalinka, Agata Sakowicz, Piotr Laudanski
INTRODUCTION: The aim of this study was to analyse a panel of 60 angiogenic factors (pro-angiogenic and antiangiogenic) in the plasma of women with mild preeclampsia. MATERIALS AND METHODS: We recruited 21 women between 25 and 40 weeks gestation with diagnosed mild preeclampsia into the study group and 27 healthy women with uncomplicated pregnancies of corresponding gestational age to that of the study to the control group. We used a quantitative protein macroarray method that allowed for analysis of 60 angiogenic proteins per sample simultaneously...
October 27, 2017: Cytokine
https://www.readbyqxmd.com/read/29110608/the-profile-of-angiogenic-factors-in-vitreous-humor-of-the-patients-with-proliferative-diabetic-retinopathy
#13
Y Yu, J Zhang, R Zhu, R Zhao, J Chen, J Jin, Y Tian, S B Su
OBJECTIVE: To explore the expression profile of angiogenic factors associated with proliferative diabetic retinopathy (PDR). METHODS: Undiluted vitreous humor samples were obtained from 10 diabetic patients with PDR (10 eyes) and 9 non-diabtic patients (9 eyes). The concentrations of 60 angiogenic factors in the vitreous humor samples were measured by RayBio Angiogenic Cytokine Antibody Array. Some differentially expressed factors were further confirmed in vitreous humor by enzyme-linked immunosorbent assay (ELISA)...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29059469/fat-free-muscle-mass-in-magnetic-resonance-imaging-predicts-acute-on-chronic-liver-failure-and-survival-in-decompensated-cirrhosis
#14
Michael Praktiknjo, Marius Book, Julian Luetkens, Alessandra Pohlmann, Carsten Meyer, Daniel Thomas, Christian Jansen, Andreas Feist, Johannes Chang, Jochen Grimm, Jennifer Lehmann, Christian P Strassburg, Juan Gonzalez Abraldes, Guido Kukuk, Jonel Trebicka
BACKGROUND: Muscle mass seems to be a prognostic marker in patients with liver cirrhosis. However, reported methods to quantify muscle mass are heterogeneous, consented cut-off values are missing and most studies used computed tomography (CT). This study evaluated fat-free muscle area as a marker of sarcopenia using magnetic resonance imaging (MRI) in decompensated cirrhotic patients with transjugular intrahepatic portosystemic shunt (TIPS). METHODS: The total erector spinae muscle area and the intramuscular fat tissue area were measured and subtracted to calculate the fat-free muscle area (FFMA) in 116 cirrhotic patients with TIPS and MRI...
October 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29058696/donor-and-recipient-plasma-follistatin-levels-are-associated-with-acute-gvhd-in-blood-and-marrow-transplant-clinical-trials-network-0402
#15
L M Turcotte, T E DeFor, L F Newell, C S Cutler, M R Verneris, J Wu, A Howard, M L MacMillan, J H Antin, G M Vercellotti, Ane Slungaard, B R Blazar, D J Weisdorf, A Panoskaltsis-Mortari, S G Holtan
Follistatin is an angiogenic factor elevated in the circulation after allogeneic hematopoietic cell transplantation (HCT). Elevations in follistatin plasma concentrations are associated with the onset of and poor survival after acute GvHD (aGvHD). Using data from the Blood and Marrow Transplant Clinical Trials Network 0402 study (n=247), we sought to further quantify the longitudinal associations between plasma follistatin levels in transplant recipients, as well as baseline HCT donor follistatin levels, and allogeneic HCT outcomes...
October 23, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29048681/effects-of-fstl1-on-cell-proliferation-in-breast-cancer-cell-line-mda%C3%A2-mb%C3%A2-231-and-its-brain-metastatic-variant-mda%C3%A2-mb%C3%A2-231%C3%A2-br
#16
Jiaqiang An, Lulu Wang, Yuanli Zhao, Qiang Hao, Ying Zhang, Jingyi Zhang, Chun Yang, Li Liu, Wenjuan Wang, Dongliang Fang, Tao Lu, Yan Gao
In the past decades, altered Follistatin‑like 1 (FSTL1) expression has been documented in a variety of cancers, while its functional roles are poorly understood. Particularly in breast cancer, the expression of FSTL1 and its signaling pathway remain to be determined. In the present study, an elevated FSTL1 expression and a supressed cell proliferation were detected in a specific brain metastatic cell line MDA‑MB‑231‑BR (231‑BR), compared with its parental cell line MDA‑MB‑231. However, this protein was hardly detected in the other three breast cancer cell lines...
September 26, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29030492/comparative-analysis-of-activins-a-and-b-in-the-adult-mouse-epididymis-and-vas-deferens
#17
Rukmali Wijayarathna, David de Kretser, Rajini Sreenivasan, Helen Ludlow, Ralf Middendorff, Andreas Meinhardt, Kate L Loveland, Mark P Hedger
Activin A regulates testicular and epididymal development, but the role of activin B in the epididymis and vas deferens is unknown. Mouse models with reduced activin A (Inhba(+/-) and Inhba(BK/+)), or its complete absence (Inhba(BK/BK)), were investigated to identify specific roles of activins in the male reproductive tract. In 8 week old Inhba(+/-) mice, serum activin A decreased by 70%, with a 50% reduction of gene expression and protein in the testis, epididymis and vas deferens. Activin B and the activin-binding protein, follistatin, were similar to wild-type...
October 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29020616/the-emerging-role-of-follistatin-under-stresses-and-its-implications-in-diseases
#18
REVIEW
Lingda Zhang, Kangli Liu, Bing Han, Zhengping Xu, Xiangwei Gao
Follistatin (FST), a single-chain glycosylated protein, is expressed in various tissues. The essential biological function of FST is binding and neutralizing transforming growth factor β (TGF-β) superfamily, including activin, myostatin, and bone morphogenetic protein (BMP). Emerging evidence indicates that FST also serves as a stress responsive protein, which plays a protective role under a variety of stresses. In most cases, FST performs the protective function through its neutralization of TGF-β superfamily...
October 8, 2017: Gene
https://www.readbyqxmd.com/read/28967680/circulating-proteins-as-predictors-of-incident-heart-failure-in-the-elderly
#19
Markus Stenemo, Christoph Nowak, Liisa Byberg, Johan Sundström, Vilmantas Giedraitis, Lars Lind, Erik Ingelsson, Tove Fall, Johan Ärnlöv
AIMS: To identify novel risk markers for incident heart failure using proteomic profiling of 80 proteins previously associated with cardiovascular pathology. METHODS AND RESULTS: Proteomic profiling (proximity extension assay) was performed in two community-based prospective cohorts of elderly individuals without heart failure at baseline: the Prospective Investigation of the Vasculature in Uppsala Seniors [PIVUS, n = 901, median age 70.2 (interquartile range 70...
October 2, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28964418/serum-biomarkers-may-prognosticate-recurrence-in-node-negative-non-small-cell-lung-cancers-less-than-4-centimeters
#20
COMPARATIVE STUDY
Christopher W Seder, Andrew T Arndt, Lia Jordano, Sanjib Basu, Cristina L Fhied, Selina Sayidine, Gary W Chmielewski, Kelsey Gallo, Michael J Liptay, Jeffrey A Borgia
BACKGROUND: A significant proportion of patients who undergo lung resection for less than 4 cm non-small cell lung cancer (NSCLC) will die of disease recurrence within 5 years. The ability to identify patients at greatest risk for recurrence may help individualize treatment and surveillance regimens and improve outcomes. We hypothesized that a serum-based biomarker panel could help risk stratify patients with node-negative NSCLC less than 4 cm for recurrence after lung resection. METHODS: An institutional biorepository of more than 1,800 cases was used to identify patients with resected, node-negative NSCLC less than 4 cm in size...
November 2017: Annals of Thoracic Surgery
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