Abdul Karim Ghaith, Oluwaseun O Akinduro, A Yohan Alexander, Anshit Goyal, Antonio Bon-Nieves, Leonardo de Macedo Filho, Andrea Otamendi-Lopez, Karim Rizwan Nathani, Kingsley Abode-Iyamah, Mark E Jentoft, Bernard R Bendok, Michelle J Clarke, Michael J Link, Jamie J Van Gompel, Alfredo Quiñones-Hinojosa, Mohamad Bydon
OBJECTIVE: Chordomas are rare tumors from notochordal remnants and account for 1%-4% of all primary bone malignancies, often arising from the clivus and sacrum. Despite margin-negative resection and postoperative radiotherapy, chordomas often recur. Further, immunohistochemical (IHC) markers have not been assessed as predictive of chordoma recurrence. The authors aimed to identify the IHC markers that are predictive of postoperative long-term (≥ 1 year) chordoma recurrence by using trained multiple tree-based machine learning (ML) algorithms...
June 2023: Neurosurgical Focus