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clivus chordoma

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https://www.readbyqxmd.com/read/28515451/hoxa7-hoxa9-and-hoxa10-are-differentially-expressed-in-clival-and-sacral-chordomas
#1
Daniela Jäger, Thomas F E Barth, Silke Brüderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, André Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss, Christian R Wirtz, Peter Möller, Kevin Mellert
Chordomas are rare tumours of the bone arising along the spine from clivus to sacrum. We compared three chordoma cell lines of the clivus region including the newly established clivus chordoma cell line, U-CH14, with nine chordoma cell lines originating from sacral primaries by morphology, on genomic and expression levels and with patient samples from our chordoma tissue bank. Clinically, chordomas of the clivus were generally smaller in size at presentation and patients with sacral chordomas had more metastases and more often recurrent disease...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28430034/um-chor1-establishment-and-characterization-of-the-first-validated-clival-chordoma-cell-line
#2
John Henry Owen, Christine M Komarck, Anthony C Wang, Waleed M Abuzeid, Richard F Keep, Erin L McKean, Stephen Sullivan, Xing Fan, Mark E P Prince
OBJECTIVE Chordomas are rare malignant tumors thought to arise from remnants of the notochord. They can be located anywhere along the axial skeleton but are most commonly found in the clival and sacrococcygeal regions, where the notochord regresses during fetal development. Chordomas are resistant to many current therapies, leaving surgery as the primary method of treatment. Cancer cell lines have been useful for developing new cancer treatments in a laboratory setting that can then be transferred to the clinic, but there are only 4 validated chordoma cell lines available...
April 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28409727/clival-chordomas-considerations-after-16-years-of-endoscopic-endonasal-surgery
#3
Matteo Zoli, Laura Milanese, Rocco Bonfatti, Marco Faustini-Fustini, Gianluca Marucci, Giovanni Tallini, Corrado Zenesini, Carmelo Sturiale, Giorgio Frank, Ernesto Pasquini, Diego Mazzatenta
OBJECTIVE In the past decade, the role of the endoscopic endonasal approach (EEA) has relevantly evolved for skull base tumors. In this study, the authors review their surgical experience with using an EEA in the treatment of clival chordomas, which are deep and infiltrative skull base lesions, and they highlight the advantages and limitations of this ventral approach. METHODS All consecutive cases of chordoma treated with an EEA between 1998 and 2015 at a single institution are included in this study. Preoperative assessment consisted of neuroimaging (MRI and CT with angiography sequences) and endocrinological, neurological, and ophthalmological evaluations, which were repeated 3 months after surgery and annually thereafter...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28228324/extended-maxillotomy-for-skull-base-access-in-contemporary-management-of-chordomas-rationale-and-technical-aspect
#4
Muhammad Fahmi Abdul Jalil, Rowan D Story, Myron Rogers
Minimally invasive approaches to the central skull base have been popularized over the last decade and have to a large extent displaced 'open' procedures. However, traditional skull base surgery still has its role especially when dealing with a large clival chordoma where maximal surgical resection is the principal goal to maximize patient survival. In this paper, we present a case of a 25year-old male patient with chordoma in the inferior clivus which was initially debulked via a transnasal endoscopic approach...
May 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27924417/surgical-resection-of-skull-base-chordomas-experience-in-case-selection-for-surgical-approach-according-to-anatomical-compartments-and-review-of-the-literature
#5
Nir Shimony, Lior Gonen, Ben Shofty, Avraham Abergel, Dan M Fliss, Nevo Margalit
BACKGROUND: Chordoma is a rare bony malignancy known to have a high rate of local recurrence after surgery. The best treatment paradigm is still being evaluated. We report our experience and review the literature. We emphasize on the difference between endoscopic and open craniotomy in regard to the anatomical compartment harboring the tumor, the limitations of the approaches and the rate of surgical resection. METHOD: We retrospectively collected all patients with skull-base chordomas operated on between 2004 and 2014...
December 6, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27609115/differences-in-sex-distribution-anatomic-location-and-mr-imaging-appearance-of-pediatric-compared-to-adult-chordomas
#6
Ronnie Sebro, Thomas DeLaney, Francis Hornicek, Joseph Schwab, Edwin Choy, G Petur Nielsen, Daniel I Rosenthal
BACKGROUND: Chordomas are rare malignancies that primarily affect adults, but also rarely affect pediatric patients. We compared the imaging appearance, demographic and anatomic distributions of adult and pediatric chordomas in a large cohort. METHODS: We performed a retrospective review of medical records of 220 subjects with histologically confirmed chordomas of the axial skeleton and pre-treatment magnetic resonance imaging studies. Age, sex, type of chordoma (conventional, chondroid or dedifferentiated), the anatomic location of the chordoma, as well as whether the lesion was primarily extra-osseous were recorded...
2016: BMC Medical Imaging
https://www.readbyqxmd.com/read/27502775/maximum-surgical-resection-and-adjuvant-intensity-modulated-radiotherapy-with-simultaneous-integrated-boost-for-skull-base-chordoma
#7
Jun Won Kim, Chang-Ok Suh, Chang-Ki Hong, Eui Hyun Kim, Ik Jae Lee, Jaeho Cho, Kyu-Sung Lee
BACKGROUND: Local recurrence is common after surgical resection of clivus chordoma. We report the results of maximum surgical resection followed by intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB). METHODS: We reviewed 14 consecutive clivus chordoma cases undergoing postoperative IMRT-SIB using the institutional protocol between 2005 and 2013. Total and near-total resections were achieved in 11 patients (78.6 %), partial in 2 patients (14...
August 9, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27491867/spine-extra-osseous-chordoma-mimicking-neurogenic-tumors-report-of-three-cases-and-review-of-the-literatures
#8
REVIEW
Jian Yang, Xinghai Yang, Wujun Miao, Qi Jia, Wei Wan, Tong Meng, Zhipeng Wu, Xiaopan Cai, Dianwen Song, Jianru Xiao
BACKGROUND: For a long time, chordoma has been known as an osseous tumor mainly found at the clivus and sacrococcygeal region. However, spine extra-osseous chordoma (SEC) with a better prognosis than the classic type has been neglected. According to our literature review, only several case reports have been published in English literatures. Here in this article, three cases of SEC, plus a literature review, are presented. CASE PRESENTATION: Three cases of SEC were presented from our center...
August 4, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27441157/primary-bone-tumors-of-the-skull-spectrum-of-125-cases-with-review-of-literature
#9
Aanchal Kakkar, Aruna Nambirajan, Vaishali Suri, Chitra Sarkar, Shashank S Kale, Manmohan Singh, Mehar Chand Sharma
AIMS: Primary skull bone tumors, benign or malignant, are rare, and include a vast repertoire of lesions. These tumors are not reported systematically in the literature, with most studies being on individual entities or as single case reports. METHODS: Primary bone tumors diagnosed over a period of 12 years were retrieved, histological diagnoses reviewed, and clinical parameters noted. RESULTS: We identified 125 primary skull bone tumors. The mean age at diagnosis was 32 years (range: 2-65 years)...
August 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27433420/endoscopic-endonasal-approach-for-transclival-resection-of-a-petroclival-meningioma-a-technical-note
#10
Walter C Jean, Daniel R Felbaum, Amjad Anaizi, Timothy R DeKlotz
The endoscopic endonasal transclival approach has been widely described for its use to resect clivus chordomas, but there have only been isolated reports of its use for petroclival meningiomas. These tumors are most often resected utilizing open transpetrosal approaches, but these operations, difficult even in the hands of dedicated skull base surgeons, are particularly challenging if the meningiomas are medially-situated and positioned mainly behind the clivus. For this subset of petroclival meningiomas, a transclival approach may be preferable...
2016: Curēus
https://www.readbyqxmd.com/read/27330428/tumour-seeding-in-the-surgical-pathway-after-resection-of-skull-base-chordoma
#11
Marco Krengli, Arturo Poletti, Eleonora Ferrara, Piero Fossati
AIM: The aim of this study is to review the clinical series in which tumour seeding was reported after skull base surgery for chordomas. BACKGROUND: The occurrence of implantation of cancer cells during surgical procedures for the removal of chordoma is a rare event described by a number of authors in a few patient series and case reports. MATERIALS AND METHODS: Literature search was performed by PubMed and Scopus by using the words "surgical tumour seeding, tumour implantation, surgical pathway recurrence, skull base chordoma, and clivus chordoma"...
July 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27303859/clivus-chordomas-a-systematic-review-and-meta-analysis-of-contemporary-surgical-management
#12
REVIEW
Moujahed Labidi, Kentaro Watanabe, Schahrazad Bouazza, Damien Bresson, Anne L Bernat, Bernard George, Sébastien Froelich
INTRODUCTION: Chordomas are rare bony lesions arising from notochordal remnants. Technical advances in endoscopic surgery have allowed the median endonasal corridor to be used for a larger number of chordoma cases. However, very few studies have critically examined the data in support of the anterior midline approach (AMA), as compared to lateral and posterolateral transcranial corridors. EVIDENCE ACQUISITION: A systematic search of the literature was done in March 2016 using EMBASE and PubMed for articles published between January 2006 and March 2016 to identify surgical series of clivus chordomas...
December 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27278644/the-use-of-a-three-dimensional-endoscope-for-different-skull-base-tumors-results-of-a-preliminary-extended-endonasal-surgical-series
#13
Giuseppe Catapano, Matteo de Notaris, Domenico Di Maria, Luis Alonso Fernandez, Giuseppe Di Nuzzo, Vincenzo Seneca, Giuseppina Iorio, Iacopo Dallan
BACKGROUND: The evolution of skull base surgery over the past decade has been influenced by advancement in visualization technology. Recently, as a result of such improvements, three-dimensional (3-D) scopes have been widely used during endoscopic endonasal approaches. In the present study, we describe the use of 3-D stereoscopic endoscope for the treatment of a variety of skull base lesions. METHODS: From January 2010 to June 2015, a 3-D endoscopic endonasal approach (4 and 4...
August 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27206421/ecchordosis-physaliphora-typical-and-atypical-radiologic-features
#14
Hun Ho Park, Kyu-Sung Lee, Sung Jun Ahn, Sang Hyun Suh, Chang-Ki Hong
Ecchordosis physaliphora (EP) is a distinct clinical entity defined as a notochordal remnant found on the dorsal surface of the clivus, occurring in about 2 % of autopsies. The aim of this study is to introduce typical and atypical imaging features of EP, which can be confused with those of clival chordoma. Forty-one patients with clinical suspicion for clival chordoma visited the outpatient clinic from June 2007 to August 2015. A retrospective review was performed with magnetic resonance imaging (MRI) and computed tomography (CT) studies to revise the diagnosis to EP...
January 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/27072875/establishment-of-clival-chordoma-cell-line-mug-cc1-and-lymphoblastoid-cells-as-a-model-for-potential-new-treatment-strategies
#15
Verena Gellner, Peter Valentin Tomazic, Birgit Lohberger, Katharina Meditz, Ellen Heitzer, Michael Mokry, Wolfgang Koele, Andreas Leithner, Bernadette Liegl-Atzwanger, Beate Rinner
Chordomas are rare malignant tumors that develop from embryonic remnants of the notochord and arise only in the midline from the clivus to the sacrum. Surgery followed by radiotherapy is the standard treatment. As chordomas are resistant to standard chemotherapy, further treatment options are urgently needed. We describe the establishment of a clivus chordoma cell line, MUG-CC1. The cell line is characterized according to its morphology, immunohistochemistry, and growth kinetics. During establishment, cell culture supernatants were collected, and the growth factors HGF, SDF-1, FGF2, and PDGF analyzed using xMAP(®) technology...
April 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26972706/novel-reconstruction-of-the-anterior-craniocervical-junction-using-an-expandable-cage-with-integrated-fixation-after-total-c2-spondylectomy-for-chordoma
#16
Joshua T Wewel, Ravi S Nunna, Lee A Tan, Manish K Kasliwal, John E O'Toole
Chordoma is a locally aggressive malignant tumor that generally occurs in the clivus, mobile spine and sacrum. While en bloc resection with wide margins has been advocated as the only cure for chordomas, tumor characteristics and violation of critical anatomical boundaries may preclude pursuing this treatment option in the cervical spine. We present a C2 chordoma in a 35-year-old man with epidural and prevertebral extension that was treated with a single stage anterior-posterior total C2 spondylectomy with novel reconstruction using an expandable cage with integrated fixation followed by stereotactic radiosurgery...
August 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26968445/anterior-spinal-reconstruction-to-the-clivus-using-an-expandable-cage-after-c2-chordoma-resection-via-a-labiomandibular-glossotomy-approach-a-technical-report
#17
Alp Ozpinar, Jesse J Liu, Nathaniel L Whitney, Zachary J Tempel, Philip A Choi, Peter E Andersen, Nicholas D Coppa, D Kojo Hamilton
INTRODUCTION: En bloc resection of high-cervical chordomas is a technically challenging procedure associated with significant morbidity. Two key components of this procedure include the approach and the method of spinal reconstruction. A limited number of reported cases of en bloc resection of high-cervical chordomas have been reported in the literature. CASE PRESENTATION: We report a novel case using an expandable cage to reconstruct the anterior spinal column above C2 with fixation to the clivus...
June 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26885420/clival-ectopic-pituitary-adenoma-mimicking-a-chordoma-case-report-and-review-of-the-literature
#18
Constantine L Karras, Isaac Josh Abecassis, Zachary A Abecassis, Joseph G Adel, Esther N Bit-Ivan, Rakesh K Chandra, Bernard R Bendok
Background. Purely ectopic pituitary adenomas are exceedingly rare. Here we report on a patient that presented with an incidental clival mass thought to be a chordoma. Endonasal resection, tumor pathology, and endocrinology workup revealed a prolactinoma. Case Presentation. A 41-year-old male presented with an incidental clival lesion presumed to be a chordoma. On MRI it involved the entire clivus, extended laterally to the petroclival junction, and invaded the cavernous sinuses bilaterally, encasing both internal carotid arteries, without direct extension into the sella...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/26810468/bone-invasiveness-is-associated-with-prognosis-in-clivus-chordomas
#19
Ke Wang, Liang Wang, Zhen Wu, Kaibing Tian, Cong Ren, Guijun Jia, Liwei Zhang, Junting Zhang
Clivus chordomas present a great challenge for neurosurgeons, and the prognosis is poor. To investigate bone invasiveness characteristics in regard to the prognosis of clivus chordomas, a retrospective study of 19 patients with primary clivus chordoma was performed. Clinical data, MRI, CT scans and follow-up data were examined, and the bone invasiveness of the chordoma was classified into two growth patterns (endophytic and exophytic) which were analyzed with regard to prognosis. The overall survival rate was 78...
May 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26623237/nasopharyngeal-masses-arising-from-embryologic-remnants-of-the-clivus-a-case-series
#20
Mirabelle Sajisevi, Jenny K Hoang, Rose Eapen, David W Jang
Objectives This study aims to (1) discuss rare nasopharyngeal masses originating from embryologic remnants of the clivus, and (2) discuss the embryology of the clivus and understand its importance in the diagnosis and treatment of these masses. Design and Participants This is a case series of three patients. We discuss the clinical and imaging characteristics of infrasellar craniopharyngioma, intranasal extraosseous chordoma, and canalis basilaris medianus. Results Case 1: A 16-year-old male patient with a history of craniopharyngioma resection, who presented with nasal obstruction...
November 2015: Journal of Neurological Surgery Reports
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