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Michael Richardson

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https://www.readbyqxmd.com/read/28329761/somatic-mutations-reveal-asymmetric-cellular-dynamics-in-the-early-human-embryo
#1
Young Seok Ju, Inigo Martincorena, Moritz Gerstung, Mia Petljak, Ludmil B Alexandrov, Raheleh Rahbari, David C Wedge, Helen R Davies, Manasa Ramakrishna, Anthony Fullam, Sancha Martin, Christopher Alder, Nikita Patel, Steve Gamble, Sarah O'Meara, Dilip D Giri, Torril Sauer, Sarah E Pinder, Colin A Purdie, Åke Borg, Henk Stunnenberg, Marc van de Vijver, Benita K T Tan, Carlos Caldas, Andrew Tutt, Naoto T Ueno, Laura J van 't Veer, John W M Martens, Christos Sotiriou, Stian Knappskog, Paul N Span, Sunil R Lakhani, Jórunn Erla Eyfjörd, Anne-Lise Børresen-Dale, Andrea Richardson, Alastair M Thompson, Alain Viari, Matthew E Hurles, Serena Nik-Zainal, Peter J Campbell, Michael R Stratton
Somatic cells acquire mutations throughout the course of an individual's life. Mutations occurring early in embryogenesis are often present in a substantial proportion of, but not all, cells in postnatal humans and thus have particular characteristics and effects. Depending on their location in the genome and the proportion of cells they are present in, these mosaic mutations can cause a wide range of genetic disease syndromes and predispose carriers to cancer. They have a high chance of being transmitted to offspring as de novo germline mutations and, in principle, can provide insights into early human embryonic cell lineages and their contributions to adult tissues...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28317464/molecular-mechanisms-of-pulmonary-response-progression-in-crystalline-silica-exposed-rats
#2
Rajendran Sellamuthu, Christina Umbright, Jenny R Roberts, Shih-Houng Young, Diana Richardson, Walter McKinney, Bean T Chen, Shengqiao Li, Michael Kashon, Pius Joseph
An understanding of the mechanisms underlying diseases is critical for their prevention. Excessive exposure to crystalline silica is a risk factor for silicosis, a potentially fatal pulmonary disease. Male Fischer 344 rats were exposed by inhalation to crystalline silica (15 mg/m(3), six hours/day, five days) and pulmonary response was determined at 44 weeks following termination of silica exposure. Additionally, global gene expression profiling in lungs and BAL cells and bioinformatic analysis of the gene expression data were done to understand the molecular mechanisms underlying the progression of pulmonary response to silica...
March 19, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28299842/electroacupuncture-promotes-cns-dependent-release-of-mesenchymal-stem-cells
#3
Tatiana E Salazar, Matthew R Richardson, Eleni Beli, Matthew S Ripsch, John George, Youngsook Kim, Yaqian Duan, Leni Moldovan, Yuanqing Yan, Ashay Bhatwadekar, Vaishnavi Jadhav, Jared A Smith, Susan McGorray, Alicia L Bertone, Dmitri O Traktuev, Keith L March, Luis M Colon-Perez, Keith Avin, Emily Sims, Julie A Mund, Jamie Case, Shaolin Deng, Min Su Kim, Bruce McDavitt, Michael E Boulton, Jeffrey Thinschmidt, Sergio Li Calzi, Stephanie D Fitz, Robyn K Fuchs, Stuart J Warden, Todd McKinley, Anantha Shekhar, Marcelo Febo, Phillip L Johnson, Lung Ji Chang, Zhanguo Gao, Mikhail G Kolonin, Song Lai, Jinfeng Ma, Xinzhong Dong, Fletcher A White, Huisheng Xie, Mervin C Yoder, Maria B Grant
Electro-acupuncture (EA) performed in rats and humans using front-limb acupuncture sites, LI-4 and LI-11, and Du-14 and Du-20 increased functional connectivity between the anterior hypothalamus and the amygdala and mobilized mesenchymal stem cells (MSC) into the systemic circulation. In human subjects, the source of the MSC was found to be primarily adipose tissue whereas in rodents the tissue sources were considered more heterogeneous. Pharmacological disinhibition of rat hypothalamus enhanced sympathetic nervous system (SNS) activation and similarly resulted in a release of MSC into the circulation...
March 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28299434/pathologies-of-the-shoulder-and-elbow-affecting-the-overhead-throwing-athlete
#4
REVIEW
Sean Wo, Hyojeong Mulcahy, Michael L Richardson, Felix S Chew, Albert Gee, Jason Hsu, Jack Porrino
The overhead-throwing athlete is susceptible to a variety of predictable disease entities affecting the shoulder and elbow. While the pathophysiology and nomenclature of these diseases are ubiquitous throughout the clinical literature, this information is sparse within the radiology domain. We provide a comprehensive review of these unique injuries with accompanying imaging features in an effort to enhance the role of the radiologist during the management of the overhead thrower. When appropriately recognized and described, the imaging features aid in establishing a diagnosis and ultimately the implementation of appropriate clinical management...
March 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28291473/physiological-impact-of-platelet-apheresis-in-pigs-oxygen-metabolism-and-coagulation
#5
Wenjun Z Martini, Cassandra M Rodriguez, Jonathan Richardson, James K Aden, Andrew P Cap, Michael A Dubick
INTRODUCTION: Platelet apheresis is a routine clinical practice, but the physiological impact on the donors has been incompletely characterized. This study measured the effects of platelet apheresis on hemodynamics, oxygen metabolism, and coagulation in pigs to assess its impact before employing the animals in experimental studies. METHODS: Forty pigs (39.8 ± 0.6 kg) were anesthetized and catheterized with an apheresis catheter in the femoral vein. During the platelet apheresis process, blood was withdrawn from the pig to separate platelets, and the remaining red blood cells and plasma returned back to the pigs, using the Haemonetics MCS+9000 system...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28288110/hrdetect-is-a-predictor-of-brca1-and-brca2-deficiency-based-on-mutational-signatures
#6
Helen Davies, Dominik Glodzik, Sandro Morganella, Lucy R Yates, Johan Staaf, Xueqing Zou, Manasa Ramakrishna, Sancha Martin, Sandrine Boyault, Anieta M Sieuwerts, Peter T Simpson, Tari A King, Keiran Raine, Jorunn E Eyfjord, Gu Kong, Åke Borg, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, Anne-Lise Børresen-Dale, John W M Martens, Paul N Span, Sunil R Lakhani, Anne Vincent-Salomon, Christos Sotiriou, Andrew Tutt, Alastair M Thompson, Steven Van Laere, Andrea L Richardson, Alain Viari, Peter J Campbell, Michael R Stratton, Serena Nik-Zainal
Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors. Thus, assays to detect BRCA1/BRCA2-deficient tumors have been sought. Recently, somatic substitution, insertion/deletion and rearrangement patterns, or 'mutational signatures', were associated with BRCA1/BRCA2 dysfunction...
March 13, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28275050/novel-thiosemicarbazones-inhibit-lysine-rich-ceacam1-co-isolated-lyric-and-the-lyric-induced-epithelial-mesenchymal-transition-via-up-regulation-of-n-myc-downstream-regulated-gene-1-ndrg1
#7
Ruxing Xi, Ivan Ho Yuen Pun, Sharleen V Menezes, Leyla Fouani, Danuta S Kalinowski, Michael L H Huang, Xiaozhi Zhang, Des R Richardson, Zaklina Kovacevic
Tumor necrosis factor α (TNFα) plays a vital role in cancer progression, being associated with inflammation and promotion of cancer angiogenesis and metastasis. The effects of TNFα are mediated by its down-stream target, the oncogene, lysine-rich CEACAM1 co-isolated protein (LYRIC; also known as metadherin or astrocyte elevated gene-1). LYRIC plays an important role in activating the nuclear factor-κB (NF-κB) signaling pathway, which controls multiple cellular processes, including proliferation, apoptosis, migration, etc...
March 8, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28271925/aarhus-regenerative-orthopaedics-symposium-aros
#8
Casper B Foldager, Michael Bendtsen, Lise C Berg, Jan E Brinchmann, Mats Brittberg, Cody Bunger, Jose Canseco, Li Chen, Bjørn B Christensen, Pauline Colombier, Bent W Deleuran, James Edwards, Brian Elmengaard, Jack Farr, Birgitta Gatenholm, Andreas H Gomoll, James H Hui, Rune B Jakobsen, Natasja L Joergensen, Moustapha Kassem, Thomas Koch, Søren Kold, Michael R Krogsgaard, Henrik Lauridsen, Dang Le, Catherine Le Visage, Martin Lind, Jens V Nygaard, Morten L Olesen, Michael Pedersen, Martin Rathcke, James B Richardson, Sally Roberts, Jan H D Rölfing, Daisuke Sakai, Wei Seong Toh, Jill Urban, Myron Spector
The combination of modern interventional and preventive medicine has led to an epidemic of ageing. While this phenomenon is a positive consequence of an improved lifestyle and achievements in a society, the longer life expectancy is often accompanied by decline in quality of life due to musculoskeletal pain and disability. The Aarhus Regenerative Orthopaedics Symposium (AROS) 2015 was motivated by the need to address regenerative challenges in an ageing population by engaging clinicians, basic scientists, and engineers...
December 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/28258897/local-hypothermia-as-a-radioprotector-of-the-rectal-wall-during-prostate-stereotactic-body-radiation-therapy
#9
Brian A Hrycushko, Rajiv Chopra, James W Sayre, James A Richardson, Michael R Folkert, Robert D Timmerman, Paul M Medin
PURPOSE: To compare the single-fraction dose-related incidence of rectal obstruction and/or bleeding in normothermic and hypothermic rectums of a rat model. METHODS AND MATERIALS: A 1.9-cm length of rectum was irradiated with a single fraction in 57 Sprague-Dawley rats using a dedicated image-guided small animal irradiator and Monte Carlo-based treatment planning system. All rats had a rectal temperature control apparatus placed during irradiation and were stratified to achieve either a normothermic (37°C) or hypothermic (15°C) rectal wall temperature...
January 11, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28254486/sar-of-amino-pyrrolidines-as-potent-and-novel-protein-protein-interaction-inhibitors-of-the-prc2-complex-through-eed-binding
#10
Michael L Curtin, Marina A Pliushchev, Huan-Qiu Li, Maricel Torrent, Justin D Dietrich, Clarissa G Jakob, Haizhong Zhu, Hongyu Zhao, Ying Wang, Zhiqin Ji, Richard F Clark, Kathy A Sarris, Sujatha Selvaraju, Bailin Shaw, Mikkel A Algire, Yupeng He, Paul L Richardson, Ramzi F Sweis, Chaohong Sun, Gary G Chiang, Michael R Michaelides
Herein we disclose SAR studies of a series of dimethylamino pyrrolidines which we recently reported as novel inhibitors of the PRC2 complex through disruption of EED/H3K27me3 binding. Modification of the indole and benzyl moieties of screening hit 1 provided analogs with substantially improved binding and cellular activities. This work culminated in the identification of compound 2, our nanomolar proof-of-concept (PoC) inhibitor which provided on-target tumor growth inhibition in a mouse xenograft model. X-ray crystal structures of several inhibitors bound in the EED active-site are also discussed...
April 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28231042/cost-effectiveness-analysis-of-four-simulated-colorectal-cancer-screening-interventions-north-carolina
#11
Kristen Hassmiller Lich, David A Cornejo, Maria E Mayorga, Michael Pignone, Florence K L Tangka, Lisa C Richardson, Tzy-Mey Kuo, Anne-Marie Meyer, Ingrid J Hall, Judith Lee Smith, Todd A Durham, Steven A Chall, Trisha M Crutchfield, Stephanie B Wheeler
INTRODUCTION: Colorectal cancer (CRC) screening rates are suboptimal, particularly among the uninsured and the under-insured and among rural and African American populations. Little guidance is available for state-level decision makers to use to prioritize investment in evidence-based interventions to improve their population's health. The objective of this study was to demonstrate use of a simulation model that incorporates synthetic census data and claims-based statistical models to project screening behavior in North Carolina...
February 23, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28228893/-tennis-leg-gastrocnemius-injury-is-a-far-more-common-cause-than-plantaris-rupture
#12
Joelle R Harwin, Michael L Richardson
We report a typical case of "tennis leg", in which the main finding was a fluid collection between the medial head of the gastrocnemius and soleus muscles. Since the first clinical description of this entity in 1883, the injury has been attributed to rupture of the plantaris tendon. However, recent studies of this condition with sonography and magnetic resonance imaging have shown that most of these cases are actually due to injury to the gastrocnemius and/or soleus muscles, and up to 10% are due to deep venous thrombosis masquerading as muscle injury...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28210537/multilevel-predictors-of-colorectal-cancer-testing-modality-among-publicly-and-privately-insured-people-turning-50
#13
Stephanie B Wheeler, Tzy-Mey Kuo, Anne Marie Meyer, Christa E Martens, Kristen M Hassmiller Lich, Florence K L Tangka, Lisa C Richardson, Ingrid J Hall, Judith Lee Smith, Maria E Mayorga, Paul Brown, Trisha M Crutchfield, Michael P Pignone
Understanding multilevel predictors of colorectal cancer (CRC) screening test modality can help inform screening program design and implementation. We used North Carolina Medicare, Medicaid, and private, commercially available, health plan insurance claims data from 2003 to 2008 to ascertain CRC test modality among people who received CRC screening around their 50th birthday, when guidelines recommend that screening should commence for normal risk individuals. We ascertained receipt of colonoscopy, fecal occult blood test (FOBT) and fecal immunochemical test (FIT) from billing codes...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28210231/effects-of-agent-environment-symmetry-on-the-coordination-dynamics-of-triadic-jumping
#14
Akifumi Kijima, Hiroyuki Shima, Motoki Okumura, Yuji Yamamoto, Michael J Richardson
We investigated whether the patterns of coordination that emerged during a three-participant (triadic) jumping task were defined by the symmetries of the (multi) agent-environment task space. Triads were instructed to jump around different geometrical arrangements of hoops. The symmetry of the hoop geometry was manipulated to create two symmetrical and two asymmetrical participant-hoop configurations. Video and motion tracking recordings were employed to determine the frequencies of coordination misses (collisions or failed jumps) and during 20 successful jump sequences, the jump direction chosen (clockwise vs...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#15
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28207729/proposed-new-industry-code-on-unhealthy-food-marketing-to-children-and-young-people-will-it-make-a-difference
#16
Boyd Swinburn, Stefanie Vandevijvere, Alistair Woodward, Andrew Hornblow, Ann Richardson, Barbara Burlingame, Barry Borman, Barry Taylor, Bernhard Breier, Bruce Arroll, Bernadette Drummond, Cameron Grant, Chris Bullen, Clare Wall, Cliona Ni Mhurchu, David Cameron-Smith, David Menkes, David Murdoch, Dee Mangin, Diana Lennon, Diana Sarfati, Doug Sellman, Elaine Rush, Faafetai Sopoaga, George Thomson, Gerry Devlin, Gillian Abel, Harvey White, Jane Coad, Janet Hoek, Jennie Connor, Jeremy Krebs, Jeroen Douwes, Jim Mann, John McCall, John Broughton, John D Potter, Les Toop, Lesley McCowan, Louise Signal, Lutz Beckert, Mark Elwood, Marlena Kruger, Mauro Farella, Michael Baker, Michael Keall, Murray Skeaff, Murray Thomson, Nick Wilson, Nicholas Chandler, Papaarangi Reid, Patricia Priest, Paul Brunton, Peter Crampton, Peter Davis, Philip Gendall, Philippa Howden-Chapman, Rachael Taylor, Richard Edwards, Robert Beaglehole, Robert Doughty, Robert Scragg, Robin Gauld, Robert McGee, Rod Jackson, Roger Hughes, Roger Mulder, Ruth Bonita, Rozanne Kruger, Sally Casswell, Sarah Derrett, Shanthi Ameratunga, Simon Denny, Simon Hales, Sue Pullon, Susan Wells, Tim Cundy, Tony Blakely
Reducing the exposure of children and young people to the marketing of unhealthy foods is a core strategy for reducing the high overweight and obesity prevalence in this population. The Advertising Standards Authority (ASA) has recently reviewed its self-regulatory codes and proposed a revised single code on advertising to children. This article evaluates the proposed code against eight criteria for an effective code, which were included in a submission to the ASA review process from over 70 New Zealand health professors...
February 17, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28207645/hazards-of-standard-epidural-test-dose-in-laboring-parturients
#17
Michael G Richardson
No abstract text is available yet for this article.
March 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28192181/in-vitro-development-of-zebrafish-vascular-networks
#18
Muhammad Ibrahim, Michael K Richardson
A major limitation to culturing tissues and organs is the lack of a functional vascular network in vitro. The zebrafish possess many useful properties which makes it a promising model for such studies. Unfortunately, methods of culturing endothelial cells from this species are not well characterised. Here, we tried two methods (embryoid body culture and organ explants from transgenic zebrafish kdrl:GFP embryos) to develop in vitro vascular networks. In the kdrl:GFP line, endothelial cells expresses green fluorescent protein, which allows to track the vascular development in live cultures...
February 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28158632/impact-of-pre-exposure-history-and-host-genetics-on-antibody-avidity-following-norovirus-vaccination
#19
Lisa C Lindesmith, Michael L Mallory, Taylor A Jones, Charles Richardson, Robert R Goodwin, Frank Baehner, Paul M Mendelman, Robert F Bargatze, Ralph S Baric
No abstract text is available yet for this article.
February 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28156461/utilizing-electronic-technologies-to-measure-patient-reported-outcomes-pro-assessment-completion-time
#20
Tony Lam, Marsha N Richardson, Ellen F Manzullo, Michael Kallen, DerShung Yang, Niina Mari Haas, Carmelita P Escalante
69 Background: Patient-reported outcomes (PROs) contribute to the assessment and treatment of cancer-related fatigue (CRF). Paper-based symptom assessments are cumbersome and time-consuming. Electronic assessments are an efficient alternative. This study describes CRF Clinic patients at a major cancer Institution, the time they required to complete self-reported CRF symptom assessments via a tablet computer (iPad), and the factors influencing PRO assessment completion time. METHODS: From 1/1/2011 to 8/21/2012, 190 newly-referred CRF Clinic patients utilized an iPad to complete standardized CRF symptom assessments for: fatigue, pain, depression, anxiety, stress, sleepiness, and apathy...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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