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Michael Richardson

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https://www.readbyqxmd.com/read/28632532/postpartum-tubal-sterilization-making-the-case-for-urgency
#1
Michael G Richardson, Sarah J Hall, Lisa C Zuckerwise
The parturient who requests postpartum sterilization has given consideration to and has made decisions regarding this aspect of her medical care long before her delivery. She arrives at parturition expecting the postpartum procedure to be performed as intended. The American Congress of Obstetricians and Gynecologists has reaffirmed its opinion that postpartum sterilization is an urgent procedure, owing to the safety and superior effectiveness of tubal sterilization via minilaparotomy in the immediate postpartum period, and the adverse consequences for mothers, babies, and society when the procedure is not actualized as desired and intended...
June 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28631842/uk-consensus-statement-on-the-use-of-plerixafor-to-facilitate-autologous-peripheral-blood-stem-cell-collection-to-support-high-dose-chemoradiotherapy-for-patients-with-malignancy
#2
Kenneth W Douglas, Maria Gilleece, Patrick Hayden, Hannah Hunter, Peter R E Johnson, Charlotte Kallmeyer, Ram K Malladi, Shankara Paneesha, Rachel Pawson, Michael Quinn, Kavita Raj, Deborah Richardson, Stephen Robinson, Nigel Russell, John Snowden, Anna Sureda, Eleni Tholouli, Kirsty Thomson, Mike Watts, Keith M Wilson
Plerixafor is a CXC chemokine receptor (CXCR4) antagonist that mobilizes stem cells in the peripheral blood. It is indicated (in combination with granulocyte-colony stimulating factor [G-CSF]) to enhance the harvest of adequate quantities of cluster differentiation (CD) 34+ cells for autologous transplantation in patients with lymphoma or multiple myeloma whose cells mobilize poorly. Strategies for use include delayed re-mobilization after a failed mobilization attempt with G-CSF, and rescue or pre-emptive mobilization in patients in whom mobilization with G-CSF is likely to fail...
June 20, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28630177/integrated-genome-and-transcriptome-sequencing-identifies-a-noncoding-mutation-in-the-genome-replication-factor-donson-as-the-cause-of-microcephaly-micromelia-syndrome
#3
Gilad D Evrony, Dwight R Cordero, Jun Shen, Jennifer N Partlow, Timothy W Yu, Rachel E Rodin, R Sean Hill, Michael E Coulter, Anh-Thu N Lam, Divya Jayaraman, Dianne Gerrelli, Diana G Diaz, Chloe Santos, Victoria Morrison, Antonella Galli, Ulrich Tschulena, Stefan Wiemann, M Jocelyne Martel, Betty Spooner, Steven C Ryu, Princess C Elhosary, Jillian M Richardson, Danielle Tierney, Christopher A Robinson, Rajni Chibbar, Dana Diudea, Rebecca Folkerth, Sheldon Wiebe, A James Barkovich, Ganeshwaran H Mochida, James Irvine, Edmond G Lemire, Patricia Blakley, Christopher A Walsh
While next-generation sequencing has accelerated the discovery of human disease genes, progress has been largely limited to the "low hanging fruit" of mutations with obvious exonic coding or canonical splice site impact. In contrast, the lack of high-throughput, unbiased approaches for functional assessment of most noncoding variants has bottlenecked gene discovery. We report the integration of transcriptome sequencing (RNA-seq), which surveys all mRNAs to reveal functional impacts of variants at the transcription level, into the gene discovery framework for a unique human disease, microcephaly-micromelia syndrome (MMS)...
June 19, 2017: Genome Research
https://www.readbyqxmd.com/read/28627286/constipation-related-health-care-utilization-in-children-before-and-after-hospitalization-for-constipation
#4
John R Stephens, Michael J Steiner, Neal DeJong, Jonathan Rodean, Matt Hall, Troy Richardson, Jay G Berry
We studied constipation-related health care among children before and after constipation admission. Index admissions for constipation in 2010-2011 were identified in the Truven Marketscan Database, which includes children receiving Medicaid in 10 states. We measured number of and spending for outpatient constipation visits 12 months before and after index hospitalizations. We also measured spending for constipation hospitalizations and rehospitalization rate. There were 780 index constipation admissions. The median number of outpatient constipation visits was 1 (interquartile range [IQR] = 0, 3) in the 12 months before and 2 (IQR [0, 4]) after admission ( P = ...
February 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28622810/exploratory-examination-of-the-utility-of-demoralization-as-a-diagnostic-specifier-for-adjustment-disorder-and-major-depression
#5
D W Kissane, I Bobevski, P Gaitanis, J Brooker, N Michael, C Lethborg, G Richardson, P Webster, C Hempton
OBJECTIVE: Demoralization, a state of lowered morale and poor coping, has a prevalence of 13-18% among patients with advanced cancer. We surveyed clinicians' perspectives of the utility of "with demoralization" as a diagnostic specifier for adjustment and depressive disorders. METHOD: Using comparative clinical vignettes in a field survey, clinicians from a range of disciplines were asked their perception of the utility of diagnosis and treatment options. Response frequencies were compared using Cochran's Q and McNemar's tests, with sensitivity and specificity rated against expert rankings of diagnosis...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28610984/sar-and-characterization-of-non-substrate-isoindoline-urea-inhibitors-of-nicotinamide-phosphoribosyltransferase-nampt
#6
Michael L Curtin, H Robin Heyman, Richard F Clark, Bryan K Sorensen, George A Doherty, T Matthew Hansen, Robin R Frey, Kathy A Sarris, Ana L Aguirre, Anurupa Shrestha, Noah Tu, Kevin Woller, Marina A Pliushchev, Ramzi F Sweis, Min Cheng, Julie L Wilsbacher, Peter J Kovar, Jun Guo, Dong Cheng, Kenton L Longenecker, Diana Raich, Alla V Korepanova, Nirupama B Soni, Mikkel A Algire, Paul L Richardson, Violeta L Marin, Ilaria Badagnani, Anil Vasudevan, F Greg Buchanan, David Maag, Gary G Chiang, Chris Tse, Michael R Michaelides
Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the terminal functionality of screening hit 5 provided inhibitors such as 52 and 58 with nanomolar antiproliferative activity and preclinical pharmacokinetics properties which enabled potent antitumor activity when dosed orally in mouse xenograft models. X-ray crystal structures of two inhibitors bound in the NAMPT active-site are discussed...
June 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28604778/p63-exerts-spatio-temporal-control-of-palatal-epithelial-cell-fate-to-prevent-cleft-palate
#7
Rose Richardson, Karen Mitchell, Nigel L Hammond, Maria Rosaria Mollo, Evelyn N Kouwenhoven, Niki D Wyatt, Ian J Donaldson, Leo Zeef, Tim Burgis, Rognvald Blance, Simon J van Heeringen, Hendrik G Stunnenberg, Huiqing Zhou, Caterina Missero, Rose Anne Romano, Satrajit Sinha, Michael J Dixon, Jill Dixon
Cleft palate is a common congenital disorder that affects up to 1 in 2500 live births and results in considerable morbidity to affected individuals and their families. The aetiology of cleft palate is complex with both genetic and environmental factors implicated. Mutations in the transcription factor p63 are one of the major individual causes of cleft palate; however, the gene regulatory networks in which p63 functions remain only partially characterized. Our findings demonstrate that p63 functions as an essential regulatory molecule in the spatio-temporal control of palatal epithelial cell fate to ensure appropriate fusion of the palatal shelves...
June 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28602612/lineage-reprogramming-of-astroglial-cells-from-different-origins-into-distinct-neuronal-subtypes
#8
Malek Chouchane, Ana Raquel Melo de Farias, Daniela Maria de Sousa Moura, Markus Michael Hilscher, Timm Schroeder, Richardson Naves Leão, Marcos Romualdo Costa
Astroglial cells isolated from the rodent postnatal cerebral cortex are particularly susceptible to lineage reprogramming into neurons. However, it remains unknown whether other astroglial populations retain the same potential. Likewise, little is known about the fate of induced neurons (iNs) in vivo. In this study we addressed these questions using two different astroglial populations isolated from the postnatal brain reprogrammed either with Neurogenin-2 (Neurog2) or Achaete scute homolog-1 (Ascl1). We show that cerebellum (CerebAstro) and cerebral cortex astroglia (CtxAstro) generates iNs with distinctive neurochemical and morphological properties...
June 5, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28594766/postdischarge-opioid-use-after-cesarean-delivery
#9
Sarah S Osmundson, Leslie A Schornack, Jennifer L Grasch, Lisa C Zuckerwise, Jessica L Young, Michael G Richardson
OBJECTIVE: To characterize postdischarge opioid use and examine factors associated with variation in opioid prescribing and consumption. METHODS: We conducted a prospective observational cohort study by recruiting all women undergoing cesarean delivery during an 8-week period, excluding those with major postoperative morbidities or chronic opioid use. Starting on postoperative day 14, women were queried weekly regarding number of opioid pills used, amount remaining, and their pain experience until they had stopped opioid medication...
June 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28594499/medial-unicompartmental-knee-arthroplasty
#10
Andrew Barrister Richardson, Michael J Morris
Unicompartmental knee arthroplasty (UKA) has substantial benefits, including lower perioperative morbidity and earlier recovery, compared with total knee arthroplasty. The traditionally strict indications for UKA have been challenged by studies that expanded the indications based on a diagnosis of anteromedial osteoarthritis of the knee and demonstrated successful outcomes. The Nuffield criteria no longer prohibit patients from UKA based on age, obesity, anterior knee pain, or involvement of the patellofemoral joint...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594000/synthesis-and-preliminary-pet-imaging-of-11-c-and-18-f-isotopologues-of-the-ros1-alk-inhibitor-lorlatinib
#11
Thomas Lee Collier, Marc D Normandin, Nickeisha A Stephenson, Eli Livni, Steven H Liang, Dustin W Wooten, Shadi A Esfahani, Michael G Stabin, Umar Mahmood, Jianqing Chen, Wei Wang, Kevin Maresca, Rikki N Waterhouse, Georges El Fakhri, Paul Richardson, Neil Vasdev
Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-small cell lung cancers. An early goal is to measure the concentrations of this drug in brain tumour lesions of lung cancer patients, as penetration of the blood-brain barrier is important for optimal therapeutic outcomes...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28590041/evaluating-the-importance-of-social-motor-synchronization-and-motor-skill-for-understanding-autism
#12
Paula Fitzpatrick, Veronica Romero, Joseph L Amaral, Amie Duncan, Holly Barnard, Michael J Richardson, R C Schmidt
Impairments in social interaction and communicating with others are core features of autism spectrum disorder (ASD), but the specific processes underlying such social competence impairments are not well understood. An important key for increasing our understanding of ASD-specific social deficits may lie with the social motor synchronization that takes place when we implicitly coordinate our bodies with others. Here, we tested whether dynamical measures of synchronization differentiate children with ASD from controls and further explored the relationships between synchronization ability and motor control problems...
June 7, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28535381/the-evolution-of-fangs-venom-and-mimicry-systems-in-blenny-fishes
#13
Nicholas R Casewell, Jeroen C Visser, Kate Baumann, James Dobson, Han Han, Sanjaya Kuruppu, Michael Morgan, Anthony Romilio, Vera Weisbecker, Karine Mardon, Syed A Ali, Jordan Debono, Ivan Koludarov, Ivo Que, Gregory C Bird, Gavan M Cooke, Amanda Nouwens, Wayne C Hodgson, Simon C Wagstaff, Karen L Cheney, Irina Vetter, Louise van der Weerd, Michael K Richardson, Bryan G Fry
No abstract text is available yet for this article.
May 22, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28533893/expression-of-pattern-recognition-receptor-genes-and-mortality-in-patients-with-colorectal-adenocarcinoma
#14
Kathryn E Royse, Liang Chen, David H Berger, Michael M Ittmann, Hashem B El-Serag, Courtney J Balentine, David Y Graham, Peter A Richardson, Rolando E Rumbaut, Xiaoyun Shen, Donna L White, Li Jiao
Toll-like receptors (TLRs) and the receptor for advanced glycation end products (AGER) are pattern recognition receptors that regulate intestinal inflammatory homeostasis. However, their relevance in colorectal cancer (CRC) prognosis is unclear. We investigated expression of TLRs, AGER, and interacting proteins in association with CRC mortality in a retrospective cohort study of 65 males diagnosed with primary resectable CRC between 2002 and 2009. Multiplex quantitative nuclease protection assay was used to quantify the expression of 19 genes in archived tissues of tumor and paired adjacent normal mucosa...
2017: International Journal of Molecular Epidemiology and Genetics
https://www.readbyqxmd.com/read/28493603/age-related-endothelial-dysfunction-in-human-skeletal-muscle-feed-arteries-the-role-of-free-radicals-derived-from-mitochondria-in-the-vasculature
#15
Song-Young Park, Oh Sung Kwon, Robert H I Andtbacka, John R Hyngstrom, Van Reese, Michael P Murphy, Russell S Richardson
AIM: This study sought to determine the role of free radicals derived from mitochondria in the vasculature in the recognized age-related endothelial dysfunction of human skeletal muscle feed arteries (SMFAs). METHODS: A total of 44 SMFAs were studied with and without acute exposure to the mitochondria-targeted antioxidant MitoQ and nitric oxide synthase (NOS) blockade. The relative abundance of proteins from the electron transport chain, phosphorylated (p-) to endothelial (e) NOS ratio, manganese superoxide dismutase (MnSOD), and the mitochondria-derived superoxide (O2(-) ) levels were assessed in SMFA...
May 11, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28491275/outflow-tract-septation-and-the-aortic-arch-system-in-reptiles-lessons-for-understanding-the-mammalian-heart
#16
Robert E Poelmann, Adriana C Gittenberger-de Groot, Marcel W M Biermans, Anne I Dolfing, Armand Jagessar, Sam van Hattum, Amanda Hoogenboom, Lambertus J Wisse, Rebecca Vicente-Steijn, Merijn A G de Bakker, Freek J Vonk, Tatsuya Hirasawa, Shigeru Kuratani, Michael K Richardson
BACKGROUND: Cardiac outflow tract patterning and cell contribution are studied using an evo-devo approach to reveal insight into the development of aorto-pulmonary septation. RESULTS: We studied embryonic stages of reptile hearts (lizard, turtle and crocodile) and compared these to avian and mammalian development. Immunohistochemistry allowed us to indicate where the essential cell components in the outflow tract and aortic sac were deployed, more specifically endocardial, neural crest and second heart field cells...
2017: EvoDevo
https://www.readbyqxmd.com/read/28486574/assessing-the-potential-for-bias-from-non-response-to-a-study-follow-up-interview-an-example-from-the-agricultural-health-study
#17
Jessica L Rinsky, David B Richardson, Steve Wing, John D Beard, Michael Alavanja, Laura E Beane Freeman, Honglei Chen, Paul K Henneberger, Freya Kamel, Dale P Sandler, Jane A Hoppin
Prospective cohort studies are important tools for identifying causes of disease. However, these studies are susceptible to attrition. When information collected after enrollment is through interview or exam, attrition leads to missing information for non-respondents. The Agricultural Health Study enrolled 52,394 farmers in 1993-1997 and collected additional information during subsequent interviews. Forty-six percent of enrolled farmers responded to the 2005-2010 interview; 7% of farmers died prior to interview...
May 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28480278/should-human-immunodeficiency-virus-specialty-clinics-treat-patients-with-hypertension-or-refer-to-primary-care-an-analysis-of-treatment-outcomes
#18
A Ben Appenheimer, Barbara Bokhour, D Keith McInnes, Kelly K Richardson, Andrew L Thurman, Brice F Beck, Mary Vaughan-Sarrazin, Steven M Asch, Amanda M Midboe, Thom Taylor, Kelly Dvorin, Allen L Gifford, Michael E Ohl
BACKGROUND: Care for people with human immunodeficiency virus (HIV) increasingly focuses on comorbidities, including hypertension. Evidence indicates that antiretroviral therapy and opportunistic infections are best managed by providers experienced in HIV medicine, but it is unclear how to structure comorbidity care. Approaches include providing comorbidity care in HIV clinics ("consolidated care") or combining HIV care with comorbidity management in primary care clinics ("shared care")...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28468779/discovery-and-characterization-of-novel-non-substrate-and-substrate-nampt-inhibitors
#19
Julie L Wilsbacher, Min Cheng, Dong Cheng, Samuel A J Trammell, Yan Shi, Jun Guo, Stormy L Koeniger, Peter J Kovar, Yupeng He, Sujatha Selvaraju, H Robin Heyman, Bryan K Sorensen, Richard F Clark, T Matthew Hansen, Kenton L Longenecker, Diana Raich, Alla V Korepanova, Steven Cepa, Danli L Towne, Vivek C Abraham, Hua Tang, Paul L Richardson, Shaun M McLoughlin, Ilaria Badagnani, Michael L Curtin, Michael R Michaelides, David Maag, F Greg Buchanan, Gary G Chiang, Wenqing Gao, Saul H Rosenberg, Charles Brenner, Chris Tse
Cancer cells are highly reliant on nicotinamide adenine dinucleotide (NAD(+))-dependent processes including glucose metabolism, calcium signaling, DNA repair, and regulation of gene expression. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD(+) salvage from nicotinamide (NAM), has been investigated as a target for anti-cancer therapy. Known NAMPT inhibitors with potent cell activity are composed of a nitrogen-containing aromatic group, which is phosphoribosylated by the enzyme...
May 3, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28453838/impact-of-pre-exposure-history-and-host-genetics-on-antibody-avidity-following-norovirus-vaccination
#20
Lisa C Lindesmith, Michael L Mallory, Taylor A Jones, Charles Richardson, Robert R Goodwin, Frank Baehner, Paul M Mendelman, Robert F Bargatze, Ralph S Baric
Background.: Development of high avidity, broadly neutralizing antibodies (Abs) is a priority after vaccination against rapidly evolving, widely disseminated viruses like human norovirus. After vaccination with a multivalent GI.1 and GII.4c norovirus virus-like particle (VLP) vaccine candidate adjuvanted with alum and monophosphoryl lipid A (MPL), blockade Ab titers peaked early, with no increase in titer following a second vaccine dose. Methods.: Blockade Ab relative avidity was evaluated by measuring the slope of blockade Ab neutralization curves...
March 15, 2017: Journal of Infectious Diseases
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