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https://www.readbyqxmd.com/read/28283528/rheumatoid-arthritis-phenotype-at-presentation-differs-depending-on-the-number-of-autoantibodies-present
#1
V F A M Derksen, S Ajeganova, L A Trouw, A H M van der Helm-van Mil, I Hafström, T W J Huizinga, R E M Toes, B Svensson, D van der Woude
OBJECTIVES: In rheumatoid arthritis (RA), seropositive and seronegative disease may be two entities with different underlying pathophysiological mechanisms, long-term outcomes and disease presentations. However, the effect of the conjoint presence of multiple autoantibodies, as proxy for a more pronounced humoral autoimmune response, on clinical phenotype remains unclear. Therefore, this study investigates the association between the number of autoantibodies and initial clinical presentation in two independent cohorts of patients with early RA...
April 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28244790/estimaci%C3%A3-n-de-la-prevalencia-de-los-fenotipos-en-pacientes-con-enfermedad-pulmonar-obstructiva-cr%C3%A3-nica-estudio-adepocle
#2
Ana Beatriz De Abajo Larriba, Enrique Méndez Rodríguez, Javier González-Gallego, Jessica Capón Álvarez, Ángel Díaz Rodríguez, Beatriz Peleteiro Cobo, Omar Mahmoud Atoui, Serafín De Abajo Olea, Víctor Lumbreras González, Juan Martínez de Mandojana Hernández
Objetivo: estimar la prevalencia de los fenotipos de enfermedad pulmonar obstructiva crónica (EPOC) en la provincia de León.Métodos: estudio epidemiológico, transversal, multicéntrico (30 centros de salud de la provincia de León). Incluyó pacientes mayores de 35 años diagnosticados y tratados de EPOC. Variables a estudio: edad, sexo, hábitat, datos antropométricos, tabaquismo, espirometría posbroncodilatadora, disnea (mMRC), reagudizaciones, gravedad (índice Bodex), hospitalizaciones, tratamiento, seguimiento y caracterización del fenotipo (GesEOPC 2014)...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28198956/evaluating-pharmaceutical-waste-disposal-in-pediatric-units
#3
Maria Angélica Randoli de Almeida, Ana Maria Miranda Martins Wilson, Maria Angélica Sorgini Peterlini
OBJECTIVE: To verify the disposal of pharmaceutical waste performed in pediatric units. METHOD: A descriptive and observational study conducted in a university hospital. The convenience sample consisted of pharmaceuticals discarded during the study period. Handling and disposal during preparation and administration were observed. Data collection took place at pre-established times and was performed using a pre-validated instrument. RESULTS: 356 drugs disposals were identified (35...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28032881/alopecia-frontal-fibrosante-una-enfermedad-en-auge
#4
A De Quintana Sancho, X Piris García, J N Valle García, M Hierro Cámara
La alopecia frontal fibrosante (AFF) es un tipo de alopecia cicatricial cuya incidencia está aumentando de forma significativa en nuestro país. Se caracteriza por un retroceso en la línea de implantación del pelo a nivel frontotemporal que afecta mayoritariamente a mujeres postmenopaúsicas, con un impacto negativo en su calidad de vida. Se asocia a menopausia precoz en un 14% de los casos y a hipotiroidismo en un 15%. Con respecto al tratamiento, son los inhibidores de la 5α-reductasa, los fármacos que han demostrado mejoría de la enfermedad en un mayor número de casos...
December 30, 2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/27982380/access-to-and-use-of-high-blood-pressure-medications-in-brazil
#5
Sotero Serrate Mengue, Andréa Dâmaso Bertoldi, Luiz Roberto Ramos, Mareni Rocha Farias, Maria Auxiliadora Oliveira, Noemia Urruth Leão Tavares, Paulo Sergio Dourado Arrais, Vera Lucia Luiza, Tatiane da Silva Dal Pizzol
OBJECTIVE: To analyze the access to and use of medicines for high blood pressure among the Brazilian population according to social and demographic conditions. METHODS: Analysis of data from Pesquisa Nacional Sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), a nationwide cross-sectional, population-based study, with probability sampling, carried out between September 2013 and February 2014 in urban households in the five Brazilian regions...
December 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27982373/prevalence-of-self-medication-in-brazil-and-associated-factors
#6
Paulo Sérgio Dourado Arrais, Maria Eneida Porto Fernandes, Tatiane da Silva Dal Pizzol, Luiz Roberto Ramos, Sotero Serrate Mengue, Vera Lucia Luiza, Noemia Urruth Leão Tavares, Mareni Rocha Farias, Maria Auxiliadora Oliveira, Andréa Dâmaso Bertoldi
OBJECTIVE: To analyze the prevalence and associated factors regarding the use of medicines by self-medication in Brazil. METHODS: This cross-sectional population-based study was conducted using data from the PNAUM (National Survey on Access, Use and Promotion of Rational Use of Medicines), collected between September 2013 and February 2014 by interviews at the homes of the respondents. All people who reported using any medicines not prescribed by a doctor or dentist were classified as self-medication practitioners...
December 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27878224/potential-drug-interactions-in-patients-given-antiretroviral-therapy
#7
Wendel Mombaque Dos Santos, Silvia Regina Secoli, Stela Maris de Mello Padoin
Objective: to investigate potential drug-drug interactions (PDDI) in patients with HIV infection on antiretroviral therapy. Methods: a cross-sectional study was conducted on 161 adults with HIV infection. Clinical, socio demographic, and antiretroviral treatment data were collected. To analyze the potential drug interactions, we used the software Micromedex(r). Statistical analysis was performed by binary logistic regression, with a p-value of ≤0.05 considered statistically significant...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27828674/development-health-and-international-policy-the-research-and-innovation-dimension
#8
Paulo Marchiori Buss, Claudia Chamas, Miriam Faid, Carlos Morel
This text main objective is to discuss development and health from the perspective of the influence of global health governance, using as the tracer the dimension of research, development, and innovation policies in health, which relate to both important inputs for the health system, like drugs and medicines, vaccines, diagnostic reagents, and equipment, and innovative concepts and practices for the improvement of health systems and public health. The authors examine the two main macro-processes that influence development and health: the post-2015 Development Agenda and the process under way in the World Health Organization concerning research and development, intellectual property, and access to health inputs...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27683791/pathophysiology-diagnosis-and-treatmentof-dumping-syndrome-and-its-relation-to-bariatric-surgery
#9
Yasmin da Silva Chaves, Afrânio Côgo Destefani
Introduction: The dumping syndrome is frequent in bariatric surgery. It is probably the most common syndrome following partial or complete gastrectomy. Its prevalence in partial gastrectomy can reach up to 50%, thus it can be a significant complication arising from some types of bariatric surgeries. Objective: Critical analysis on dumping syndrome, its pathophysiology, diagnosis and treatment. Methods: A literature review was performed using the key words: 'dumping syndrome', 'bariatric surgery' and 'rapid dumping syndrome'...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27617528/micosis-fungoide-e-inhibidores-del-tnf%C3%AE-%C3%A2-riesgo-o-beneficio
#10
Lidia Maroñas-Jiménez, Sara Burillo-Martínez, Fátima Tous-Romero, Jose Luis Rodríguez-Peralto, Javier Ortiz de Frutos, Pablo Luis Ortiz-Romero
The growing use of anti-TNF drugs during the last years has reopened the discussion about the possible increased risk of developing non-Hodgkin lymphoma in patients with such type of treatments. We present our clinical experience and critical opinion about the current situation of such issue regarding cutaneous T-cell lymphomas.El creciente uso de fármacos anti-TNF durante los últimos años ha reabierto el debate sobre el posible aumento de riesgo de linfomas no Hodgkin en los pacientes con este tipo de tratamientos...
May 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27598380/drug-drug-interactions-and-adverse-drug-reactions-in-polypharmacy-among-older-adults-an-integrative-review
#11
Maria Cristina Soares Rodrigues, Cesar de Oliveira
OBJECTIVE: to identify and summarize studies examining both drug-drug interactions (DDI) and adverse drug reactions (ADR) in older adults polymedicated. METHODS: an integrative review of studies published from January 2008 to December 2013, according to inclusion and exclusion criteria, in MEDLINE and EMBASE electronic databases were performed. RESULTS: forty-seven full-text studies including 14,624,492 older adults (≥ 60 years) were analyzed: 24 (51...
September 1, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27529446/-counterfeit-medicines-in-internet-and-the-fakeshare-european-project-experiences-and-activities-in-spain
#12
Daniel Catalán-Matamoros, Nuria González-Ochando, Henar Pecharroman-Arribas, Ana Fernández-Muelas, Stella Sandra Bentolila-Benchimol, Manuel IbarraLorente
The illicit trafficking of medicines over the Internet is a growing problem that affects public health. Since 2013, the Spanish Agency of Medicines and Medical Devices (AEMPS) participates in the European project Fakeshare, co-funded by the European Commission and coordinated by the Italian Medicines Agency (Agenzia Italiana del Farmaco, AIFA). This project aims to coordinate initiatives against the illegal supply of medicines, including from purchases through websites engaged in illegal activity, to thefts and other diversions of medicines to the illicit trafficking...
August 16, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27384206/phlebitis-associated-with-peripheral-intravenous-catheters-in-adults-admitted-to-hospital-in-the-western-brazilian-amazon
#13
Sandra Maria Sampaio Enes, Simone Perufo Opitz, André Ricardo Maia da Costa de Faro, Mavilde de Luz Gonçalves Pedreira
OBJECTIVE: To identify the presence of phlebitis and the factors that influence the development of this complication in adult patients admitted to hospital in the western Brazilian Amazon. METHOD: Exploratory study with a sample of 122 peripheral intravenous catheters inserted in 122 patients in a medical unit. Variables related to the patient and intravenous therapy were analyzed. For the analysis, we used chi-square tests of Pearson and Fisher exact test, with 5% significance level...
April 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27269219/-not-available
#14
REVIEW
Eduard Fort Casamartina, Lorena Arribas Hortiguela, Carmen Bleda Pérez, Carme Muñoz Sánchez, Imma Peiro Martínez, María Perayre Badía, Ana Clopés Estela
Durante la última década, el conocimiento de nuevos mecanismos implicados en el desarrollo del cáncer ha permitido el diseño de nuevos fármacos para su tratamiento y la mayor parte de ellos son fármacos que se administran por vía oral. Uno de los principales problemas de los pacientes oncohematológicos es la desnutrición, que suele tener causas multifactoriales (de la propia enfermedad, de los pacientes y de los diferentes tratamientos administrados). Para minimizar el impacto de la desnutrición es necesaria una intervención nutricional, ya sea adaptando la dieta o mediante la instauración de soporte nutricional artificial, en función de la gravedad de cada caso...
June 3, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27269215/-not-available
#15
REVIEW
Alberto MIján de la Torre
El síndrome de caquexia cancerosa es responsable de la muerte de un número significativo de pacientes con cáncer. Se caracteriza por la presencia de una ingesta reducida, con inflamación sistémica y un metabolismo alterado. Los enfermos presentan característicamente una progresiva pérdida de peso y de masa muscular, junto a deterioro funcional. La pérdida muscular se debe a la combinación de reducción de la síntesis proteica con aumento de su degradación. Ello conduce tanto a un acortamiento como a una reducción en el área de la fibra muscular...
June 3, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27183509/model-of-management-mo-ma-for-the-patient-with-schizophrenia-crisis-control-maintenance-relapse-prevention-and-recovery-with-long-acting-injectable-antipsychotics-lais
#16
Roberto Brugnoli, Chiara Rapinesi, Georgios D Kotzalidis, Andrea Marcellusi, Francesco S Mennini, Sergio De Filippis, Dario Carrus, Andrea Ballerini, Antonio Francomano, Giuseppe Ducci, Antonio Del Casale, Paolo Girardi
INTRODUCTION: Schizophrenia is a severe mental disease that affects approximately 1% of the population with a relevant chronic impact on social and occupational functioning and daily activities. People with schizophrenia are 2-2.5 times more likely to die early than the general population. Non-adherence to antipsychotic medications, both in chronic and first episode schizophrenia, is one of the most important risk factors for relapse and hospitalization, that consequently contributes to increased costs due to psychiatric hospitalization...
March 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27132696/chemoimmunotherapy-with-methotrexate-cytarabine-thiotepa-and-rituximab-matrix-regimen-in-patients-with-primary-cns-lymphoma-results-of-the-first-randomisation-of-the-international-extranodal-lymphoma-study-group-32-ielsg32-phase-2-trial
#17
Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Valter Torri, Christopher P Fox, Paul La Rosée, Elisabeth Schorb, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Angela Ferrari, Kim M Linton, Roberta Rudà, Mascha Binder, Tobias Pukrop, Monica Balzarotti, Alberto Fabbri, Peter Johnson, Jette Sønderskov Gørløv, Georg Hess, Jens Panse, Francesco Pisani, Alessandra Tucci, Stephan Stilgenbauer, Bernd Hertenstein, Ulrich Keller, Stefan W Krause, Alessandro Levis, Hans J Schmoll, Franco Cavalli, Jürgen Finke, Michele Reni, Emanuele Zucca, Gerald Illerhaus
BACKGROUND: Standard treatment for patients with primary CNS lymphoma remains to be defined. Active therapies are often associated with increased risk of haematological or neurological toxicity. In this trial, we addressed the tolerability and efficacy of adding rituximab with or without thiotepa to methotrexate-cytarabine combination therapy (the MATRix regimen), followed by a second randomisation comparing consolidation with whole-brain radiotherapy or autologous stem cell transplantation in patients with primary CNS lymphoma...
May 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27125614/-cholestasic-toxic-hepatitis-due-to-clopidogrel-in-a-patient-with-multiple-conditions
#18
D Etxeberria Lekuona, I Méndez López, M R Mercado, J Oteiza, M Arteaga, V Jarne
Clopidogrel is a thienopyridine-class antiplatelet drug commonly used in ischemic heart disease,cerebrovascular disease and peripheral artery disease.Liver toxicity due to this drug is very infrequent.We found 16 cases in the literature, and in only two of them liver biopsy was carried out. We report the case of a 78 year old patient with multiple conditions affected by severe toxic cholestatic hepatitis due to clopidogrel and the results of the liver biopsy performed. Hepatitis was resolved after discontinuing the drug...
2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/26901344/health-authorities-data-collection-of-thc-cbd-oromucosal-spray-l-agenzia-italiana-del-farmaco-web-registry-figures-after-1-5-years
#19
Francesco Patti
BACKGROUND: In Italy, all prescriptions for THC:CBD oromucosal spray for treatment of multiple sclerosis (MS) spasticity are linked to the official Agenzia Italiana del Farmaco (AIFA) web-based registry, which tracks the effectiveness and tolerability of medications in a prospective and observational manner. METHODS: AIFA e-registry data for THC:CBD oromucosal spray collected between January 2014 and February 2015 for 1,534 patients from 30 large Italian specialized MS centres were compiled...
2016: European Neurology
https://www.readbyqxmd.com/read/26835238/eribulin-in-pretreated-metastatic-breast-cancer-patients-results-of-the-trotter-trial-a-multicenter-retrospective-study-of-eribulin-in-real-life
#20
Ornella Garrone, Filippo Montemurro, Chiara Saggia, Nicla La Verde, Anna Maria Vandone, Mario Airoldi, Enrico De Conciliis, Michela Donadio, Francesco Lucio, Maria Antonia Polimeni, Maria Vittoria Oletti, Alice Giacobino, Marco Carlo Merlano
This retrospective multicenter analysis was aimed to evaluate clinical activity and tolerability of eribulin in pretreated metastatic breast cancer patients in clinical practice. Patients treated with eribulin from January 2012 to July 2013 were enrolled in the observational study from 10 italian hospitals. Tumor and toxicity evaluation were performed according to Agenzia Italiana Farmaco. One-hundred and thirteen patients were included in the study. Median age 62 years old. 71.7 % of the patients had visceral involvement and the majority had a burden of disease involving two or more organs with a median number of 2 (1-6)...
2016: SpringerPlus
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