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https://www.readbyqxmd.com/read/29664885/the-effect-of-hip-positioning-on-the-projected-femoral-neck-shaft-angle-a-modeling-study
#1
Abhiram R Bhashyam, Edward K Rodriguez, Paul Appleton, John J Wixted
OBJECTIVES: The femoral neck-shaft angle (NSA) is used to restore normal hip geometry during hip fracture repair. Femoral rotation is known to affect NSA measurement, but the effect of hip flexion-extension is unknown. The goals of this study were to determine and test mathematical models of the relationship between hip flexion-extension, femoral rotation and NSA. We hypothesized that hip flexion-extension and femoral rotation would result in NSA measurement error. METHODS: Two mathematical models were developed to predict NSA in varying degrees of hip flexion-extension and femoral rotation...
April 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29653242/effect-of-combined-flexion-and-external-rotation-on-measurements-of-the-proximal-femur-from-anteroposterior-pelvic-radiographs
#2
J O'Connor, M Rutherford, J Hill, D Beverland, N Dunne, A Lennon
INTRODUCTION: Fixed flexion and external rotation contractures are common in patients with hip osteoarthritis and in particular before total hip replacement (THR). We aimed to answer the following question: how does combined flexion and external rotation of the femur influence the radiographic assessment of 1) femoral offset (FO) 2) neck-shaft angle (NSA) and 3) distance (parallel to the femoral axis) from greater trochanter to femoral head centre (GT-FHC)? HYPOTHESIS: Combined flexion and external rotation impact the accuracy of two-dimensional (2D) proximal femur measurements...
April 10, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29650557/sputum-proteomics-and-airway-cell-transcripts-of-current-and-ex-smokers-with-severe-asthma-in-u-biopred-an-exploratory-analysis
#3
Kentaro Takahashi, Stelios Pavlidis, Francois Ng Kee Kwong, Uruj Hoda, Christos Rossios, Kai Sun, Matthew Loza, Fred Baribaud, Pascal Chanez, Steve J Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Sven-Eric Dahlen, N Krug, Thomas Sandstrom, Dominic E Shaw, Rene Lutter, Per Bakke, Louise J Fleming, Peter H Howarth, Massimo Caruso, Ana R Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Ratko Djukanovic, Peter J Sterk, Yike Guo, Ian M Adcock, Kian Fan Chung
Background: Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes. Methods: The U-BIOPRED severe asthma patients containing current-smokers (CSA), ex-smokers (ESA), non-smokers (NSA) and healthy non-smokers (NH) was examined. Blood and sputum cell counts, fractional exhaled nitric oxide and spirometry were obtained. Exploratory proteomic analysis of sputum supernatants and transcriptomic analysis of bronchial brushings, biopsies and sputum cells was performed...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29628403/spanish-validation-of-the-negative-symptom-assessment-16-nsa-16-in-patients-with-schizophrenia
#4
Leticia Garcia-Alvarez, María Paz Garcia-Portilla, Pilar Alejandra Saiz, Eduardo Fonseca-Pedrero, María Teresa Bobes-Bascaran, Jesús Gomar, José Muñiz, Julio Bobes
INTRODUCTION: Negative symptoms are prevalent in schizophrenia and associated with a poorer outcome. Validated newer psychometric instruments could contribute to better assessment and improved treatment of negative symptoms. The Negative Symptom Assessment-16 (NSA-16) has been shown to have strong psychometric properties, but there is a need for validation in non-English languages. This study aimed to examine the psychometric properties of a Spanish version of the NSA-16 (Sp-NSA-16). MATERIAL AND METHOD: Observational, cross-sectional validation study in a sample of 123 outpatients with schizophrenia...
April 5, 2018: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29614353/necrosulfonamide-attenuates-the-spinal-cord-injury-via-necroptosis-inhibition
#5
Yongxiang Wang, Jingcheng Wang, Hua Wang, Xinmin Feng, Yuping Tao, Jiandong Yang, Jun Cai
Spinal cord injury (SCI) is a serious trauma without efficient treatment currently. Necroptosis can be blocked post injury by special inhibitors. To investigate the effects of Necrosulfonamide (NSA) in the treatment of SCI, pathological condition, necroptosis related factors, mitochondrial function and ethological performance were detected. Pathological detection using HE staining was performed first. Reduced lesions and protected neurons were found in the injured spinal cord after treatment with NSA. No obvious toxicity on rat liver, kidney, heart and spleen was detected using HE staining...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29595284/-treat-to-target-in-gouty-arthritis
#6
Karel Pavelka
Gout is a crystal-induced, metabolically determined inflammatory rheumatic disease with increasing prevalence. In clinical practice, gout causes frequent diagnostic as well as therapeutic problems. The golden diagnostic standard is crystalographic analysis and evidence of monosodium urate crystals in the polarization microscope; if this is not available, the diagnosis can be established through a combination of clinical, laboratory and imaging techniques. The acute gouty attack must be treated by quick administration of anti-inflammatory medicines, with available alternatives being nonsteroidal antirheumatic drugs (NSA), colchicine and glucocorticoids...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29595274/-chronic-pain-therapy-in-inflammatory-rheumatic-diseases
#7
David Suchý, Jan Lejčko
Chronic pain is a common health problem related to most of inflammatory rheumatic disorders. It is pain that has persisted for at least 3 month and cannot be fully relieved by standard pain medication. 40-60 % of patients do not have adequate relief of their pain. Paramount in the management of chronic pain patients is assessment of the pain and its impact on physical and psychosocial functioning. Multidisciplinary and multimodal approach is of vital importance. Non-steroidal anti-rheumatic drugs (NSA) have been used mainly due to their strong analgesic effect, especially in the treatment of acute pain as well as their anti-inflammatory effect in the treatment of chronic i pain...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29567105/proximal-and-distal-alignment-of-normal-canine-femurs-a-morphometric-analysis
#8
Mehmet Erkut Kara, Figen Sevil-Kilimci, Ömer Gürkan Dilek, Vedat Onar
Many researchers are interested in femoral conformation because most orthopaedic problems of the long bones occur in the femur and its joints. The neck-shaft (NSA) and the anteversion (AVA) angles are good predictors for understanding the orientation of the proximal end of the femur. The varus (aLDFA) and procurvatum (CDFA) angles have also been used to understand the orientation of the distal end of the femur. The purposes of this study were to investigate the relationship between the proximal and distal angles of the femur and to compare the distal femoral angles in male and female dogs in order to investigate the sexual dimorphism...
March 19, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29564500/high-throughput-genotyping-by-sequencing-facilitates-molecular-tagging-of-a-novel-rust-resistance-gene-r-15-in-sunflower-helianthus-annuus-l
#9
G J Ma, Q J Song, S G Markell, L L Qi
A novel rust resistance gene, R15 , derived from the cultivated sunflower HA-R8 was assigned to linkage group 8 of the sunflower genome using a genotyping-by-sequencing approach. SNP markers closely linked to R15 were identified, facilitating marker-assisted selection of resistance genes. The rust virulence gene is co-evolving with the resistance gene in sunflower, leading to the emergence of new physiologic pathotypes. This presents a continuous threat to the sunflower crop necessitating the development of resistant sunflower hybrids providing a more efficient, durable, and environmentally friendly host plant resistance...
March 21, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29534880/the-impact-of-changes-in-radiographic-sarcopenia-on-overall-survival-in-older-adults-undergoing-different-treatment-pathways-for-pancreatic-cancer
#10
Andrew J Benjamin, Mary M Buschmann, Shuang Qin Zhang, Kristen Wroblewski, Hedy L Kindler, Kevin K Roggin, William Dale
OBJECTIVE: Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS: Computed tomography (CT) total psoas area index (TPAI) and weighted average Hounsfield units (HU) were measured at each treatment interval in patients with resectable PDAC. Four cohorts were compared: 1...
March 10, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29526410/impingement-type-bony-morphology-was-related-to-cartilage-defects-but-not-pain-in-professional-ballet-dancers-hips
#11
Susan Mayes, Peter Smith, Jill Cook
OBJECTIVES: Professional ballet dancers may have hip bony morphology that predisposes them to cartilage or labral injury. However, the relationship between bony morphology and pathology has not been investigated in ballet. This study investigates associations between bony morphology, chondrolabral defects and hip pain in ballet dancers. DESIGN: Cross-sectional study. METHODS: 33 male and female professional ballet dancers, (mean age 27 years (range 19-39)), completed questionnaires with hip pain measured on a visual analogue scale; and underwent 3...
March 3, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29526153/surgical-reconstruction-of-hip-subluxation-and-dislocation-in-children-with-cerebral-palsy
#12
Murat Oto, İlker Abdullah Sarıkaya, Ozan Ali Erdal, Ali Şeker
OBJECTIVES: This study aims to review the efficacy of femoral varus derotation osteotomy (VDRO) and Dega transiliac osteotomy in the treatment of hip subluxation and dislocation of cerebral palsy (CP) patients. PATIENTS AND METHODS: This retrospective study included 25 hips of 22 CP patients (9 males, 13 females; mean age 8.7 years; range 4 to 18 years) who were operated due to hip subluxation and dislocation between July 2010 and December 2015. The mean follow-up period was 36...
April 2018: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/29523173/upscaling-participatory-action-and-videos-for-agriculture-and-nutrition-upavan-trial-comparing-three-variants-of-a-nutrition-sensitive-agricultural-extension-intervention-to-improve-maternal-and-child-nutritional-outcomes-in-rural-odisha-india-study-protocol
#13
Suneetha Kadiyala, Audrey Prost, Helen Harris-Fry, Meghan O'Hearn, Ronali Pradhan, Shibananth Pradhan, Naba Kishore Mishra, Suchitra Rath, Nirmala Nair, Shibanand Rath, Prasantha Tripathy, Sneha Krishnan, Peggy Koniz-Booher, Heather Danton, Diana Elbourne, Joanna Sturgess, Emma Beaumont, Hassan Haghparast-Bidgoli, Jolene Skordis-Worrall, Satyanarayan Mohanty, Avinash Upadhay, Elizabeth Allen
BACKGROUND: Maternal and child undernutrition have adverse consequences for pregnancy outcomes and child morbidity and mortality, and they are associated with low educational attainment, economic productivity as an adult, and human wellbeing. 'Nutrition-sensitive' agriculture programs could tackle the underlying causes of undernutrition. METHODS/DESIGN: This study is a four-arm cluster randomised controlled trial in Odisha, India. Interventions are as follows: (1) an agricultural extension platform of women's groups viewing and discussing videos on nutrition-sensitive agriculture (NSA) practices, and follow-up visits to women at home to encourage the adoption of new practices shown in the videos; (2) women's groups viewing and discussing videos on NSA and nutrition-specific practices, with follow-up visits; and (3) women's groups viewing and discussing videos on NSA and nutrition-specific practices combined with a cycle of Participatory Learning and Action meetings, with follow-up visits...
March 9, 2018: Trials
https://www.readbyqxmd.com/read/29482067/influence-of-geometry-on-proximal-femoral-shaft-strains-implications-for-atypical-femoral-fracture
#14
Ifaz T Haider, Prism Schneider, Andrew Michalski, W Brent Edwards
INTRODUCTION: Atypical femoral fractures (AFF) are characterized as low-energy fractures of the femoral shaft or subtrochanteric region. Femoral geometry is known to play a role in AFF risk; it is hypothesized that high-risk geometries are associated with elevated femoral shaft strain. However, it is not well known which geometric parameters have the greatest effect on strain, or whether interaction between parameters is significant. The purpose of this study was to thoroughly quantify the relationship between femoral geometry and diaphyseal strain, using patient specific finite element (FE) modelling in concert with parametric mesh morphing...
February 23, 2018: Bone
https://www.readbyqxmd.com/read/29440953/are-negative-symptoms-in-schizophrenia-a-distinct-therapeutic-target
#15
Octavia Oana Capatina, Ioana Valentina Miclutia
Background and aims: The relationship between negative symptoms and cognition in schizophrenia is not clear, inconsistent findings have been reported by multiple authors and meta analyses. The aim of this study was to investigate the relationship between cognition and primary negative symptoms. Methods: 67 outpatients diagnosed with schizophrenia were evaluated using PANSS and the NSA-16 scale. Correlation and regression analyses were used in the present study to investigate the relationship between the primary negative symptoms and cognition...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29410937/understanding-antipsychotic-drug-treatment-effects-a-novel-method-to-reduce-pseudospecificity-of-the-positive-and-negative-syndrome-scale-panss-factors
#16
REVIEW
Seth C Hopkins, Ajay Ogirala, Antony Loebel, Kenneth S Koblan
The Positive and Negative Syndrome Scale (PANSS) is the most widely used efficacy measure in acute treatment studies of schizophrenia. However, interpretation of the efficacy of antipsychotics in improving specific symptom domains is confounded by moderate-to-high correlations among standard (Marder) PANSS factors. The authors review the results of an uncorrelated PANSS score matrix (UPSM) transform designed to reduce pseudospecificity in assessment of symptom change in patients with schizophrenia. Based on a factor analysis of five pooled, placebo-controlled lurasidone clinical trials (N=1,710 patients), a UPSM transform was identified that generated PANSS factors with high face validity (good correlation with standard Marder PANSS factors), and high specificity/orthogonality (low levels of between-factor correlation measuring change during treatment)...
December 1, 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29391526/whole-metagenome-sequencing-reveals-links-between-mosquito-microbiota-and-insecticide-resistance-in-malaria-vectors
#17
Nsa Dada, Mili Sheth, Kelly Liebman, Jesus Pinto, Audrey Lenhart
In light of the declining global malaria burden attained largely due to insecticides, a deeper understanding of the factors driving insecticide resistance is needed to mitigate its growing threat to malaria vector control programs. Following evidence of microbiota-mediated insecticide resistance in agricultural pests, we undertook a comparative study of the microbiota in mosquitoes of differing insecticide resistance status. The microbiota of wild-caught Anopheles albimanus, an important Latin American malaria vector, that were resistant (FEN_Res) or susceptible (FEN_Sus) to the organophosphate (OP) insecticide fenitrothion were characterized and compared using whole metagenome sequencing...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29377850/does-the-angle-of-the-nail-matter-for-pertrochanteric-fracture-reduction-matching-nail-angle-and-native-neck-shaft-angle
#18
Joshua A Parry, Ian Barrett, Bradley Schoch, Brandon Yuan, Joseph Cass, William Cross
OBJECTIVES: To determine whether fixation of pertrochanteric hip fractures with cephalomedullary nails (CMNs) with a neck-shaft angle (NSA) less than the native NSA affects reduction and lag screw cutout. DESIGN: Retrospective comparative study. SETTING: Level I trauma center. PATIENTS/PARTICIPANTS: Patients treated with a CMN for unstable pertrochanteric femur fractures (OTA/AO 31-A2.2 and 31-A2.3) between 2005 and 2014...
April 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29296991/design-of-a-porous-cobalt-sulfide-nanosheet-array-on-ni-foam-from-zeolitic-imidazolate-frameworks-as-an-advanced-electrode-for-supercapacitors
#19
Xue Han, Kai Tao, Ding Wang, Lei Han
Porous nanosheet-structured electrode materials are very attractive for the high efficiency storage of electrochemical energy. Herein, a porous cobalt sulfide nanosheet array on Ni foam (Co9 S8 -NSA/NF) is successfully fabricated by a facile method, which involves the uniform growth of 2D Co-based leaf-like zeolitic imidazole frameworks (Co-ZIF-L) on Ni foam followed by subsequent sulfurization with thioacetamide (TAA). Benefiting from the unique porous nanosheet array architecture and conductive substrate, the Co9 S8 -NSA/NF exhibits excellent electrochemical performance with a high capacitance (1098...
February 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29288345/polish-translation-and-validation-of-the-pelvic-organ-prolapse-urinary-incontinence-sexual-questionnaire-iuga-revised-pisq-ir
#20
Magdalena Emilia Grzybowska, Justyna Piaskowska-Cala, Dariusz Grzegorz Wydra
INTRODUCTION AND HYPOTHESIS: The aim of the study was to translate into Polish the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire, IUGA-Revised (PISQ-IR), which evaluates sexual function in sexually active (SA) and not SA (NSA) women with pelvic floor disorders (PFD), and to validate the Polish version. METHODS: After translation, back-translation and cognitive interviews, the final version of PISQ-IR was established. The study group included 252 women with PFD (124 NSA and 128 SA)...
December 29, 2017: International Urogynecology Journal
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