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https://www.readbyqxmd.com/read/28445878/differential-allelic-expression-of-htr1b-in-suicide-victims-genetic-and-epigenetic-effect-of-the-cis-acting-variants
#1
Ali Bani-Fatemi, Aaron Howe, Clement Zai, James L Kennedy, John Vincent, John Strauss, Albert Wong, Vincenzo De Luca
OBJECTIVES: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. METHODS: The study was conducted using 3 sets of samples. First, C861G allele-specific mRNA levels in the frontal cortex were compared between suicide (n = 13) and nonsuicide controls (n = 13) from the Stanley Medical Research postmortem brain collection. Second, we tested common variants in the HTR1B promoter for linkage disequilibrium (LD) with the C861G variant in an unrelated sample of suicide attempters (SA; n = 38) and non-SA (NSA; n = 42)...
April 27, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28438550/lipophilic-salts-of-poorly-soluble-compounds-to-enable-high-dose-lipidic-sedds-formulations-in-drug-discovery
#2
Michael Morgen, Ajay Saxena, Xue-Qing Chen, Warren Miller, Richard Nkansah, Aaron Goodwin, Jon Cape, Roy Haskell, Ching Su, Olafur Gudmundsson, Michael Hageman, Anoop Kumar, Gajendra Singh Chowan, Abhijith Rao, Vinay K Holenarsipur
Self-emulsifying drug delivery systems (SEDDS) have been used to solubilize poorly water-soluble drugs to improve exposure in high-dose pharmacokinetic (PK) and toxicokinetic (TK) studies. However, the absorbable dose is often limited by drug solubility in the lipidic SEDDS vehicle. This study focuses on increasing solubility and drug loading of ionizable drugs in SEDDS vehicles using lipophilic counterions to prepare lipophilic salts of drugs. SEDDS formulations of two lipophilic salts-atazanavir-2-naphthalene sulfonic acid (ATV-2-NSA) and atazanavir-dioctyl sulfosuccinic acid (ATV-Doc)-were characterized and their performance compared to atazanavir (ATV) free base formulated as an aqueous crystalline suspension, an organic solution, and a SEDDS suspension, using in vitro, in vivo, and in silico methods...
April 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28400660/anthropometric-analysis-of-the-hip-joint-in-south-indian-population-using-computed-tomography
#3
Vetrivel Chezian Sengodan, Elangovan Sinmayanantham, J Saravana Kumar
BACKGROUND: Proximal femur has a significant functional modification on erect bipedal posture. Various proximal femoral parameters were analyzed in Western literature. This information was utilized in prosthetic designing. Implants designed for Western people are used in Indian patients undergoing hip surgeries such as internal fixation and replacement arthroplasty. MATERIALS AND METHODS: The study was done among 200 individuals (400 hips) with a normal hip joint after ethical committee clearance...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28389782/spanish-version-of-the-pelvic-organ-prolapse-urinary-incontinence-sexual-questionnaire%C3%A2-iuga-revised-pisq-ir-%C3%A2-transcultural-validation
#4
Montserrat Mestre, Judith Lleberia, Josep Pubill, Montserrat Espuña-Pons
INTRODUCTION AND HYPOTHESIS: The aim of this study was to transculturally adapt the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire IUGA-Revised (PISQ-IR) into Spanish and to validate the new version. METHODS: We carried out a two-stage observational cross-sectional study: translation and back-translation, followed by a validation stage in which the final version was administered to 268 consecutive women (118 not sexually active [NSA] and 150 sexually active [SA]) older than 18 from an Urogynecology Unit...
April 8, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28376893/effects-of-socio-demographic-characteristics-and-household-water-management-on-aedes-aegypti-production-in-suburban-and-rural-villages-in-laos-and-thailand
#5
Nanthasane Vannavong, Razak Seidu, Thor-Axel Stenström, Nsa Dada, Hans J Overgaard
BACKGROUND: Dengue fever is a mosquito-borne disease accounting for 50-100 million annual cases globally. Laos and Thailand are countries in south-east Asia where the disease is endemic in both urban and rural areas. Household water storage containers, which are favourable breeding sites for dengue mosquitoes, are common in these areas, due to intermittent or limited access to water supply. This study assessed the effect of household water management and socio-demographic risk factors on Aedes aegypti infestation of water storage containers...
April 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28322028/localization-of-nucleoside-transporters-in-rat-epididymis
#6
David M Klein, Marcus C Harding, Meghan K Crowther, Nathan J Cherrington
The epididymis relies on transporters for the secretion of nucleosides and influence the disposition of nucleoside analogs (NSA). Since these compounds can cross the blood-testis barrier (BTB), it is important to understand if the epididymis reabsorbs NSA drugs. The purpose of this study is to determine the localization of nucleoside transporters expressed within rat epididymis to demonstrate the potential of epididymal reabsorption. Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the nucleus of the epithelium and CNT2 is expressed by basal cells...
March 21, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28321452/spontaneous-wormlike-micelles-formed-in-a-single-tailed-zwitterionic-surface-active-ionic-liquid-aqueous-solution
#7
Panpan Sun, Fei Lu, Aoli Wu, Lijuan Shi, Liqiang Zheng
Wormlike micelles were successfully fabricated by the self-assembly of a single-tailed zwitterionic surface-active ionic liquid (SAIL), 3-(1-hexadecyl-3-imidazolio) propanesulfonate β-naphthalene sulfonate (C16IPS-Nsa), in aqueous solutions without any additives. With increasing zwitterionic SAIL concentration, spontaneous transition from micelles to wormlike micelles and then a hexagonal phase occurs. Interestingly, the wormlike micelles are closed, stretched and directionally arranged, which was rarely found in previous research studies...
March 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28289909/ripk1-ripk3-mlkl-mediated-necroptosis-contributes-to-compression-induced-rat-nucleus-pulposus-cells-death
#8
Songfeng Chen, Xiao Lv, Binwu Hu, Zengwu Shao, Baichuan Wang, Kaige Ma, Hui Lin, Min Cui
The aim of this study was to systematically investigate the role of necroptosis in compression-induced rat nucleus pulposus (NP) cells death, as well as explore the underlying mechanisms involved. Rat NP cells underwent various periods of exposure to 1.0 MPa pressure. Cell viability and cell death were quantified by using cell counting kit-8 (CCK-8), and Calcein-AM/propidium iodine (PI) staining respectively. Necroptosis-associated target molecules receptor-interacing protein kinase 1 (RIPK1), phosphorylated RIPK1 (pRIPK1), receptor-interacing protein kinase 3 (RIPK3), phosphorylated RIPK3 (pRIPK3) and mixed lineage kinase domain-like (MLKL) were analyzed by Western-blot and RT-PCR...
March 13, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28221067/ethical-concerns-for-telemental-health-therapy-amidst-governmental-surveillance
#9
Samuel D Lustgarten, Alexander J Colbow
Technology, infrastructure, governmental support, and interest in mental health accessibility have led to a burgeoning field of telemental health therapy (TMHT). Psychologists can now provide therapy via computers at great distances and little cost for parties involved. Growth of TMHT within the U.S. Department of Veterans Affairs and among psychologists surveyed by the American Psychological Association (APA) suggests optimism in this provision of services (Godleski, Darkins, & Peters, 2012; Jacobsen & Kohout, 2010)...
February 2017: American Psychologist
https://www.readbyqxmd.com/read/28160079/development-and-dissection-of-diagnostic-snp-markers-for-the-downy-mildew-resistance-genes-pl-arg-and-pl-8-and-maker-assisted-gene-pyramiding-in-sunflower-helianthus-annuus-l
#10
L L Qi, Z I Talukder, B S Hulke, M E Foley
Diagnostic DNA markers are an invaluable resource in breeding programs for successful introgression and pyramiding of disease resistance genes. Resistance to downy mildew (DM) disease in sunflower is mediated by Pl genes which are known to be effective against the causal fungus, Plasmopara halstedii. Two DM resistance genes, Pl Arg and Pl 8 , are highly effective against P. halstedii races in the USA, and have been previously mapped to the sunflower linkage groups (LGs) 1 and 13, respectively, using simple sequence repeat (SSR) markers...
February 3, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28151779/coxa-vara-in-postseptic-arthritis-of-the-hip-in-children
#11
Ashok N Johari, Aravind Hampannavar, Ratna A Johari, Arjun A Dhawale
The behavior and treatment of coxa vara and pseudarthrosis of the proximal femur secondary to sepsis is not well described. The aim of this study is to describe the pathoanatomy for coxa vara and pseudarthrosis in postseptic hips, evaluate progression of neck shaft angle (NSA), and discuss treatment. This is a retrospective case series of 20 patients (21 hips). There were 11 hips with predominant avascular necrosis of the capital femoral epiphysis without pseudarthrosis (type 1) and 10 with pseudarthrosis (type 2)...
February 1, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28141691/valgus-hip-osteotomy-in-children-with-spondyloepiphyseal-dysplasia-congenita-midterm-results
#12
Ilhan A Bayhan, Oussama Abousamra, Kenneth J Rogers, Michael B Bober, Freeman Miller, William G Mackenzie
BACKGROUND: Coxa vara has been frequently reported in spondyloepiphyseal dysplasia congenita (SEDC), and proximal femoral osteotomy has been described as a useful treatment. The aim of this study was to discuss the clinical, radiographic, and gait outcomes after valgus extension osteotomy of the proximal femur. Changes of lumbar lordosis, associated with coxa vara correction, are reported as well as the outcome differences between different ages. METHODS: Records of children with SEDC, who were followed at our institution between 2004 and 2014, were reviewed; and children had hip surgery were identified...
January 30, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28106226/applied-taguchi-method-for-fatigue-testing-of-customized-hip-implant
#13
Mangesh R Dharme, Abhaykumar M Kuthe, Tushar R Deshmukh
PURPOSE: Human activities generate stresses, which vary with time and may result in fatigue failure of the customized hip implant. This study aims to investigate fatigue testing of customized hip implants using the minimum number of experiments by the Taguchi method, for 147 patients. This study was also useful to determine the influential geometrical parameters on the fatigue safety factor of customized hip implants. METHODS: Horizontal offset (HO), vertical offset (VO) and neck shaft angle (NSA) of the hip joint of 147 patients were measured on computed tomography (CT) scanned images...
February 10, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28100712/salt-management-strategy-defines-the-stem-and-leaf-hydraulic-characteristics-of-six-mangrove-tree-species
#14
Guo-Feng Jiang, Uromi Manage Goodale, Yan-Yan Liu, Guang-You Hao, Kun-Fang Cao
Mangroves in hypersaline coastal habitats are under constant high xylem tension and face great risk of hydraulic dysfunction. To investigate the relationships between functional traits and salt management, we measured 20 hydraulic and photosynthetic traits in four salt-adapted (SA) and two non-SA (NSA) mangrove tree species in south China. The SA species included two salt secretors (SSs), Avicennia marina (Forsskål) Vierhapper and Aegiceras corniculatum (L.) Blanco and two salt excluders (SEs), Bruguiera gymnorrhiza (L...
March 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28088644/tert-butyl-hydroperoxide-t-bhp-induced-apoptosis-and-necroptosis-in-endothelial-cells-roles-of-nox4-and-mitochondrion
#15
Wenwen Zhao, Haitao Feng, Wen Sun, Kang Liu, Jin-Jian Lu, Xiuping Chen
Oxidative stress causes endothelial death while underlying mechanisms remain elusive. Herein, the pro-death effect of tert-butyl hydroperoxide (t-BHP) was investigated with low concentration (50μM) of t-BHP (t-BHPL) and high concentration (500μM) of t-BHP (t-BHPH). Both t-BHPL and t-BHPH induced endothelial cell death was determined. T-BHPL induced caspase-dependent apoptosis and reactive oxygen species (ROS) generation, which was inhibited by N-acetyl-L-cysteine (NAC). Furthermore, NADPH oxidase inhibitor diphenyleneiodonium (DPI), NOX4 siRNA, and NOX4 inhibitor GKT137831 reduced t-BHPL-induced ROS generation while mitochondrial respiratory chain inhibitors rotenone (Rot), 2-thenoyltrifluoroacetone (TTFA), and antimycin A (AA) failed to do so...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28060468/reducing-hysteresis-and-enhancing-performance-of-perovskite-solar-cells-using-low-temperature-processed-y-doped-sno2-nanosheets-as-electron-selective-layers
#16
Guang Yang, Hongwei Lei, Hong Tao, Xiaolu Zheng, Junjie Ma, Qin Liu, Weijun Ke, Zhiliang Chen, Liangbin Xiong, Pingli Qin, Zhao Chen, Minchao Qin, Xinhui Lu, Yanfa Yan, Guojia Fang
Despite the rapid increase of efficiency, perovskite solar cells (PSCs) still face some challenges, one of which is the current-voltage hysteresis. Herein, it is reported that yttrium-doped tin dioxide (Y-SnO2 ) electron selective layer (ESL) synthesized by an in situ hydrothermal growth process at 95 °C can significantly reduce the hysteresis and improve the performance of PSCs. Comparison studies reveal two main effects of Y doping of SnO2 ESLs: (1) it promotes the formation of well-aligned and more homogeneous distribution of SnO2 nanosheet arrays (NSAs), which allows better perovskite infiltration, better contacts of perovskite with SnO2 nanosheets, and improves electron transfer from perovskite to ESL; (2) it enlarges the band gap and upshifts the band energy levels, resulting in better energy level alignment with perovskite and reduced charge recombination at NSA/perovskite interfaces...
January 2017: Small
https://www.readbyqxmd.com/read/28055281/effects-of-bronchoscopy-on-lung-function-in-asthmatics
#17
Christina Bellinger, Eugene R Bleecker, Stephen P Peters, Rodolfo M Pascual, Jeffrey Krings, Regina V Smith, Annette Hasties, Wendy C Moore
BACKGROUND: To better understand changes in pulmonary physiology related to asthma severity following bronchoscopy, we performed scheduled pre- and post-procedure spirometry on all subjects undergoing bronchoscopy in our research program. METHODS: Control subjects and asthma subjects of all severity were recruited for bronchoscopy. On the day of bronchoscopy, subjects underwent spirometry when they arrived, after pre-bronchoscopy treatment with albuterol and then up to three sets within two hours following completion of the bronchoscopy...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28048818/su-f-i-65-fatty-acid-quantification-in-high-fat-diet-induced-abnormal-intrahepatic-triglyceride-storage-using-internal-standard-method-at-3-0-t
#18
K-H Song, C-H Yoo, S-I Lim, B-Y Choe
PURPOSE: The objective of this study was to determine the metabolic changes in a rat model of high-fat-diet-induced non-alcoholic fatty liver disease (NAFLD) by using single-voxel 1H-MRS with a 3.0 T MRI scanner. METHODS: The examination were performed on a 3.0T scanner using a 4-channel animal coil for higher resolution. This method used point-resolved spectroscopy (PRESS) (repetition time (TR)/echo time (TE) = 6000/35 ms; number of signal averages (NSA) = 64)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046759/su-f-i-64-comparison-of-lipid-contents-using-steam-and-press-with-in-vivo-high-resolution-spectra-at-9-4-t
#19
K-H Song, S-I Lim, C-H Yoo, B-Y Choe
PURPOSE: The objective of this study is to compare lipid contents using localized point-resolved spectroscopy (PRESS) and stimulated echo acquisition mode (STEAM) sequences to assess lipid resonances in the liver, using in vivo high-resolution spectra at 9.4 T. METHODS: The examinations were performed on a Bruker 9.4T scanner using 4-channel animal coil for higher resolution. We used PRESS (repetition time [TR]/ TE = 3500/20 ms; number of signal averages [NSA] = 128; acquisition data points = 2048) and STEAM (TR/TM/TE = 3500/10/20 ms; NSA = 128; acquisition data points = 2048)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28031513/double-intertrochanteric-osteotomy-for-trochanteric-overgrowth-and-a-short-femoral-neck-in-adolescents
#20
Turgut Akgül, Cengiz Şen, Halil İbrahim Balci, Gökhan Polat
PURPOSE: To review the outcome of Wagner double intertrochanteric osteotomy for trochanteric overgrowth and a short femoral neck in 7 adolescents. METHODS: Records of one male and 6 females aged 15 to 20 years who underwent modified Wagner osteotomy for trochanteric overgrowth and a short femoral neck by a single senior surgeon were reviewed. The diagnoses were coxa vara (n=2), developmental dysplasia of the hip (n=3), Leg-Calve-Perthes (n=1), and proximal femoral focal deficiency (n=1)...
December 2016: Journal of Orthopaedic Surgery
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