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https://www.readbyqxmd.com/read/29440953/are-negative-symptoms-in-schizophrenia-a-distinct-therapeutic-target
#1
Octavia Oana Capatina, Ioana Valentina Miclutia
Background and aims: The relationship between negative symptoms and cognition in schizophrenia is not clear, inconsistent findings have been reported by multiple authors and meta analyses. The aim of this study was to investigate the relationship between cognition and primary negative symptoms. Methods: 67 outpatients diagnosed with schizophrenia were evaluated using PANSS and the NSA-16 scale. Correlation and regression analyses were used in the present study to investigate the relationship between the primary negative symptoms and cognition...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29410937/understanding-antipsychotic-drug-treatment-effects-a-novel-method-to-reduce-pseudospecificity-of-the-positive-and-negative-syndrome-scale-panss-factors
#2
REVIEW
Seth C Hopkins, Ajay Ogirala, Antony Loebel, Kenneth S Koblan
The Positive and Negative Syndrome Scale (PANSS) is the most widely used efficacy measure in acute treatment studies of schizophrenia. However, interpretation of the efficacy of antipsychotics in improving specific symptom domains is confounded by moderate-to-high correlations among standard (Marder) PANSS factors. The authors review the results of an uncorrelated PANSS score matrix (UPSM) transform designed to reduce pseudospecificity in assessment of symptom change in patients with schizophrenia. Based on a factor analysis of five pooled, placebo-controlled lurasidone clinical trials (N=1,710 patients), a UPSM transform was identified that generated PANSS factors with high face validity (good correlation with standard Marder PANSS factors), and high specificity/orthogonality (low levels of between-factor correlation measuring change during treatment)...
December 1, 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29391526/whole-metagenome-sequencing-reveals-links-between-mosquito-microbiota-and-insecticide-resistance-in-malaria-vectors
#3
Nsa Dada, Mili Sheth, Kelly Liebman, Jesus Pinto, Audrey Lenhart
In light of the declining global malaria burden attained largely due to insecticides, a deeper understanding of the factors driving insecticide resistance is needed to mitigate its growing threat to malaria vector control programs. Following evidence of microbiota-mediated insecticide resistance in agricultural pests, we undertook a comparative study of the microbiota in mosquitoes of differing insecticide resistance status. The microbiota of wild-caught Anopheles albimanus, an important Latin American malaria vector, that were resistant (FEN_Res) or susceptible (FEN_Sus) to the organophosphate (OP) insecticide fenitrothion were characterized and compared using whole metagenome sequencing...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29377850/does-the-angle-of-the-nail-matter-for-pertrochanteric-fracture-reduction-matching-nail-angle-and-native-neck-shaft-angle
#4
Joshua A Parry, Ian Barrett, Bradley Schoch, Brandon Yuan, Joseph Cass, William Cross
OBJECTIVES: To determine if fixation of pertrochanteric hip fractures with cephalomedullary nails (CMN) with a neck-shaft angle (NSA) less than the native NSA affects reduction and lag screw cutout. DESIGN: Retrospective comparative study SETTING:: Level one trauma center PATIENTS/PARTICIPANTS:: Patients treated with a CMN for unstable pertrochanteric femur fractures (OTA/AO 31-A2.2 and 31-A2.3) between 2005 and 2014 INTERVENTION:: CMN fixation MAIN OUTCOME MEASUREMENT:: NSA reduction, lag screw cutout RESULTS:: Patients fixed with a nail angle less than their native NSA were less likely to have good reductions (17% versus 60%, 95% CI -63% to -18%; p=0...
November 20, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29296991/design-of-a-porous-cobalt-sulfide-nanosheet-array-on-ni-foam-from-zeolitic-imidazolate-frameworks-as-an-advanced-electrode-for-supercapacitors
#5
Xue Han, Kai Tao, Ding Wang, Lei Han
Porous nanosheet-structured electrode materials are very attractive for the high efficiency storage of electrochemical energy. Herein, a porous cobalt sulfide nanosheet array on Ni foam (Co9S8-NSA/NF) is successfully fabricated by a facile method, which involves the uniform growth of 2D Co-based leaf-like zeolitic imidazole frameworks (Co-ZIF-L) on Ni foam followed by subsequent sulfurization with thioacetamide (TAA). Benefiting from the unique porous nanosheet array architecture and conductive substrate, the Co9S8-NSA/NF exhibits excellent electrochemical performance with a high capacitance (1098...
January 3, 2018: Nanoscale
https://www.readbyqxmd.com/read/29288345/polish-translation-and-validation-of-the-pelvic-organ-prolapse-urinary-incontinence-sexual-questionnaire-iuga-revised-pisq-ir
#6
Magdalena Emilia Grzybowska, Justyna Piaskowska-Cala, Dariusz Grzegorz Wydra
INTRODUCTION AND HYPOTHESIS: The aim of the study was to translate into Polish the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire, IUGA-Revised (PISQ-IR), which evaluates sexual function in sexually active (SA) and not SA (NSA) women with pelvic floor disorders (PFD), and to validate the Polish version. METHODS: After translation, back-translation and cognitive interviews, the final version of PISQ-IR was established. The study group included 252 women with PFD (124 NSA and 128 SA)...
December 29, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29183313/location-of-unaccessible-implant-surface-areas-during-debridement-in-simulated-peri-implantitis-therapy
#7
Valerie Steiger-Ronay, Andrea Merlini, Daniel B Wiedemeier, Patrick R Schmidlin, Thomas Attin, Philipp Sahrmann
BACKGROUND: An in vitro model for peri-implantitis treatment was used to identify areas that are clinically difficult to clean by analyzing the pattern of residual stain after debridement with commonly employed instruments. METHODS: Original data from two previous publications, which simulated surgical (SA) and non-surgical (NSA) implant debridement on two different implant systems respectively, were reanalyzed regarding the localization pattern of residual stains after instrumentation...
November 28, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29156831/protective-effect-of-nsa-on-intestinal-epithelial-cells-in-a-necroptosis-model
#8
Wei Dong, Min Zhang, Yaxi Zhu, Yuanhan Chen, Xingchen Zhao, Ruizhao Li, Li Zhang, Zhiming Ye, Xingling Liang
Objective: This study aimed to investigate the protective effect of the necroptosis inhibitor necrosulfonamide (NSA) on intestinal epithelial cells using a novel in vitro necroptosis model that mimics inflammatory bowel disease (IBD). Methods: 2,4,6-trinitrobenzenesulfonic acid (TNBS) was perfused into the rectum of BALB/c mice to established a colitis model. Pathologic injury and cell death were evaluated. A novel in vitro model of necroptosis was established in Caco-2 cells using TNF-α and Z-VAD-fmk, and the cells were treated with or without NSA...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135122/the-role-of-the-multidisciplinary-team-in-the-decision-making-process-in-stage-one-testicular-cancer-retrospective-cohort-analysis
#9
Tomislav Omrcen, Andrija Katic, Eduard Vrdoljak
PURPOSE: To analyze the role of a multidisciplinary team (MDT) in the decision-making process in clinical stage one (CS I) testicular cancer (TC). METHODS: We retrospectively evaluated data on 115 consecutive patients with CS I TC (excluding stage IS) who were referred to the Department of Oncology, University Hospital of Split, Croatia, from 2003 to 2012. Fifty-six patients (48.7%) were referred between 2003 and 2007, before the introduction of the MDT and 59 patients (51...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29104146/mlkl-pitp%C3%AE-signaling-mediated-necroptosis-contributes-to-cisplatin-triggered-cell-death-in-lung-cancer-a549-cells
#10
Lin Jing, Fei Song, Zhenyu Liu, Jianghua Li, Bo Wu, Zhiguang Fu, Jianli Jiang, Zhinan Chen
Necroptosis has been reported to be involved in cisplatin-induced cell death, but the mechanisms underlying the occurrence of necroptosis are not fully elucidated. In this study, we show that apart from apoptosis, cisplatin induces necroptosis in A549 cells. The alleviation of cell death by two necroptosis inhibitors-necrostatin-1 (Nec-1) and necrosulfonamide (NSA), and the phosphorylation of mixed lineage kinase domain-like protein (MLKL) at serine 358, suggest the involvement of receptor-interacting protein kinase 1 (RIPK1)-RIPK3-MLKL signaling in cisplatin-treated A549 cells...
November 20, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29081846/avascular-necrosis-in-children-with-cerebral-palsy-after-reconstructive-hip-surgery
#11
L Phillips, K Hesketh, E K Schaeffer, J Andrade, J Farr, K Mulpuri
PURPOSE: Progressive hip displacement is one of the most common orthopaedic pathologies in children with cerebral palsy (CP). Reconstructive hip surgery has become the standard treatment of care. Reported avascular necrosis (AVN) rates for hip reconstructive surgery in these patients vary widely in the literature. The purpose of this study is to identify the frequency and associated risk factors of AVN for reconstructive hip procedures. METHODS: A retrospective analysis was performed of 70 cases of reconstructive hip surgery in 47 children with CP, between 2009 and 2013...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29042960/application-of-3d-printing-rapid-prototyping-assisted-percutaneous-fixation-in-the-treatment-of-intertrochanteric-fracture
#12
Sheng-Nai Zheng, Qing-Qiang Yao, Feng-Yong Mao, Peng-Fei Zheng, Shu-Chang Tian, Jia-Yi Li, Yi-Fan Yu, Shuai Liu, Jin Zhou, Jun Hu, Yan Xu, Kai Tang, Yue Lou, Li-Ming Wang
The aim of the present study was to investigate the application of 3D printing (3DP) rapid prototyping (RP) technique-assisted percutaneous fixation in the treatment of femoral intertrochanteric fracture (ITF) using proximal femoral nail anti-rotation (PFNA). A total of 39 patients with unstable ITF were included in the current study. Patients were divided into two groups: 19 patients were examined using computed tomography scanning and underwent PFNA with SDP-RP whereas the other 20 patients underwent conventional PFNA treatment...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28978125/the-degradation-of-mixed-lineage-kinase-domain-like-protein-promotes-neuroprotection-after-ischemic-brain-injury
#13
Yanlong Zhou, Beiqun Zhou, Hui Tu, Yan Tang, Chen Xu, Yanbo Chen, Zhong Zhao, Zhigang Miao
Mixed lineage kinase domain-like (MLKL) protein was recently found to play a critical role in necrotic cell death. To explore its role in neurological diseases, we measured MLKL protein expression after ischemia injury in a mouse model. We found that MLKL expression significantly increased 12 h after ischemia/reperfusion (I/R) injury with peak levels at 48 h. Inhibition of MLKL by intraperitoneal administration of NSA significantly reduced infarct volume and improved neurological deficits after 75 min of ischemia and 24 h of reperfusion...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28951633/neutrophil-extracellular-dna-traps-induce-autoantigen-production-by-airway-epithelial-cells
#14
Youngwoo Choi, Le Duy Pham, Dong-Hyun Lee, Ga-Young Ban, Ji-Ho Lee, Seung-Hyun Kim, Hae-Sim Park
The hypothesis of autoimmune involvement in asthma has received much recent interest. Autoantibodies, such as anti-cytokeratin (CK) 18, anti-CK19, and anti-α-enolase antibodies, react with self-antigens and are found at high levels in the sera of patients with severe asthma (SA). However, the mechanisms underlying autoantibody production in SA have not been fully determined. The present study was conducted to demonstrate that neutrophil extracellular DNA traps (NETs), cytotoxic molecules released from neutrophils, are a key player in the stimulation of airway epithelial cells (AECs) to produce autoantigens...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28945533/ornithinimicrobium-flavum-sp-nov-isolated-from-the-leaf-of-paris-polyphylla
#15
Xiao-Mei Fang, Dong Yan, Jing-Lin Bai, Jing Su, Hong-Yu Liu, Bai-Ping Ma, Yu-Qin Zhang, Li-Yan Yu
A Gram-positive bacterium originating from the surface-sterilized leaf of Paris polyphylla var. yunnanensis (Franch.) was characterized by using a polyphasic approach. The isolate formed yellow, smooth, circular colonies on nutrient agar with 0.2 % starch (NSA). Cells were non-motile, non-sporulating, irregular rods or cocci. Strain CPCC 203535T had the highest 16S rRNA gene sequence similarity to the type strain of Ornithinimicrobium kibberense (96.9 %) and formed the deepest branch in the genus Ornithinimicrobium in the neighbour-joining (NJ) phylogenetic tree based on 16S rRNA gene sequences...
September 25, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28941285/femoral-neck-shaft-angle-and-climate-induced-body-proportions
#16
Stephanie L Child, Libby W Cowgill
OBJECTIVES: Declination in femoral neck-shaft angle (NSA) is commonly linked to an increased level of physical activity during life. More recently, however, research suggests that lower NSA might also be explained, in part, as the mechanical consequence of differences in ecogeographic body proportions. This study tests the proposed link between NSA and climatic-induced body proportions, using relative body mass (RBM), throughout the course of development. MATERIALS AND METHODS: NSA and RBM were collected for 445 immature remains from five geographic locations...
September 23, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28923396/smac-mimetics-and-type-ii-interferon-synergistically-induce-necroptosis-in-various-cancer-cell-lines
#17
Michael John Cekay, Stefanie Roesler, Tanja Frank, Anne-Kathrin Knuth, Ines Eckhardt, Simone Fulda
Since cancer cells often evade apoptosis, induction of necroptosis as another mode of programmed cell death is considered a promising therapeutic alternative. Here, we identify a novel synergistic interaction of Smac mimetics that antagonize x-linked Inhibitor of Apoptosis (XIAP), cellular Inhibitor of Apoptosis (cIAP) 1 and 2 with interferon (IFN)γ to induce necroptosis in apoptosis-resistant cancer cells in which caspase activation is blocked. This synergism is confirmed by calculation of combination indices (CIs) and found in both solid and hematological cancer cell lines as well as for different Smac mimetics (i...
September 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28922590/efficacy-and-safety-of-the-%C3%AE-7-nicotinic-acetylcholine-receptor-agonist-abt-126-in-the-treatment-of-cognitive-impairment-associated-with-schizophrenia-results-from-a-phase-2b-randomized-controlled-study-in-smokers
#18
George M Haig, Deli Wang, Jun Zhao, Ahmed A Othman, Earle E Bain
OBJECTIVE: To evaluate the efficacy and safety of the α₇-nicotinic receptor agonist ABT-126 for treatment of cognitive impairment in stable subjects with schizophrenia who smoke. METHODS: A 12-week double-blind, placebo-controlled, parallel-group study was conducted from August 2012 to March 2014. Subjects with a diagnosis of schizophrenia based on DSM-IV-TR criteria (confirmed by the Mini-International Neuropsychiatric Interview version 6.0.0) were randomized 1:1:1 to ABT-126 25 mg, ABT-126 75 mg, or placebo once daily while maintained on their background antipsychotic medication...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28902001/guided-growth-of-the-proximal-femur-for-the-management-of-hip-dysplasia-in-children-with-cerebral-palsy
#19
Nicola Portinaro, Marco Turati, Matteo Cometto, Marco Bigoni, Jon R Davids, Artemisia Panou
BACKGROUND: Progressive hip displacement is one of the most common and debilitating deformities seen in children with cerebral palsy (CP). The aim of this study was to evaluate the results of temporary medial hemiepiphysiodesis of the proximal femur (TMH-PF) using a transphyseal screw to control hip migration during growth in children with CP. METHODS: This was a retrospective study of children with CP and hip dysplasia, age 4 to 11 years and GMFCS levels III-V...
September 8, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28835046/-evaluation-of-the-proximal-femur-geometry-in-patients-with-elderly-osteoporotic-hip-fractures
#20
J X Fan, N Li, X F Gong, M H Yang, S W Zhu, X B Wu, L He
Objective: To investigate the relationship between the proximal femur geometry and elderly osteoporotic hip fractures. Methods: From May 2015 to December 2015, 137 patients with elderly osteoporotic hip fractures were involved.69 cases were in the fracture group and 68 cases were in the control group.CT scan were performed on all patients and the proximal femur geometry parameters were measured, including the neck width (NW), neck length (NL), neck shaft angle (NSA), femur head diameter (FHD), head height (HH) and Offset...
August 15, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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