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Duy Le Pham, Ga-Young Ban, Seung-Hyun Kim, Yoo Seob Shin, Young-Min Ye, Yong-Joon Chwae, Hae-Sim Park
BACKGROUND: Autophagy and neutrophil extracellular DNA traps (NETs) are implicated in asthma; however, their roles in asthma pathogenesis have not been elucidated. OBJECTIVES: We compared autophagy and NET production levels from peripheral blood neutrophils (PBNs) of patients with severe asthma (SA) and non-severe asthma (NSA). Additionally, we investigated the inflammatory effects of NETs on human airway epithelial cells (AECs) and peripheral blood eosinophils (PBEs)...
November 24, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Duc A Tien, Paul Krakovitz, Samantha Anne
INTRODUCTION: Nasal septal abscess (NSA) in the pediatric population is rare and can result in devastating complications. Objective of this study is to review a case series of pediatric patients presenting with NSA in association with acute rhinosinusitis (ARS) for possible risk factors and predisposing conditions. METHOD: This is a retrospective review of pediatric patients that presented to a tertiary care hospital with nasal septal abscess associated with ARS...
December 2016: International Journal of Pediatric Otorhinolaryngology
James N Benardini, Kasthuri Venkateswaran
The National Aeronautics and Space Administration (NASA) measures and validates the biological cleanliness of spacecraft surfaces by counting endospores using the NASA standard assay (NSA). NASA has also approved an adenosine-5'-triphosphate (ATP)-based detection methodology as a means to prescreen surfaces for the presence of microbial contamination, prior to the spore assay. During Mars Science Laboratory (MSL) spacecraft assembly, test, and launch operations, 4853 surface samples were collected to verify compliance with the bioburden requirement at launch...
December 2016: AMB Express
Vanessa Cunill, Susana Arboleya, Maria de Los Reyes Jiménez, Antoni Campins, Patricia Herbera, LLuïsa Mestre, Antonio Clemente, Maria Inés Barceló, Maria Leyes, Francesca Canellas, Maria Rosa Julià
Neuronal surface antibodies (NSA) involved in autoimmune encephalitis (AE) have been related to relapses in HVS encephalitis. Their role in non-encephalitic psychosis is controversial. We previously reported an HIV-infected patient, NSA-positive, only presenting psychosis. Therefore, we determined the NSA prevalence in a prospective cohort of 22 HIV-positive patients with psychosis and we analyzed the frequency of HIV infection among NSA tested patients due to AE suspicion. We found no NSA in the prospective cohort...
November 2, 2016: Journal of Neuroimmunology
Eduardo Dunayevich, Robert W Buchanan, Chao-Yin Chen, Jun Yang, Jon Nilsen, Julie M Dietrich, Hong Sun, Stephen Marder
OBJECTIVE: To determine the safety and efficacy of AMG 747, an oral inhibitor of glycine transporter type-1 (GlyT1), as an add-on to antipsychotic therapy in clinically stable people with schizophrenia with enduring negative symptoms. METHOD: Analysis of pooled data from two phase 2 studies. Adults diagnosed with schizophrenia stabilized on antipsychotic medication randomized (2:2:2:3) to orally receive daily AMG 747 (5mg, 15mg, or 40mg) or placebo. Primary endpoint was Negative Symptom Assessment (NSA)-16 total score change from baseline to week 12...
October 24, 2016: Schizophrenia Research
Piotr T Filipczak, Cynthia L Thomas, Wenshu Chen, Andrew Salzman, Jacob D McDonald, Yong Lin, Steven A Belinsky
Tuberous sclerosis complex (TSC) is a genetic multi-organ disorder characterized by the development of neoplastic lesions in kidney, lung, brain, heart and skin. It is caused by an inactivating mutation in tumor suppressor genes coding the TSC1/TSC2 complex, resulting in hyperactivation of mTOR- and Raf/MEK/MAPK-dependent signaling that stimulates tumor cell proliferation and metastasis. Despite its oncogenic effect, cells with TSC deficiency were more sensitive to oxidative stress and dependent on mitochondrial metabolism, providing a rationale for a new therapeutic approach...
October 18, 2016: Cancer Research
Z W Zhang, G J Ma, J Zhao, S G Markell, L L Qi
A new downy mildew resistance gene, Pl 19 , was identified from wild Helianthus annuus accession PI 435414, introduced to confection sunflower, and genetically mapped to linkage group 4 of the sunflower genome. Wild Helianthus annuus accession PI 435414 exhibited resistance to downy mildew, which is one of the most destructive diseases to sunflower production globally. Evaluation of the 140 BC1F2:3 families derived from the cross of CMS CONFSCLB1 and PI 435414 against Plasmopara halstedii race 734 revealed that a single dominant gene controls downy mildew resistance in the population...
September 27, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Qiong He, Ling Tong, Lingyun Huang, Jing Liu, Yinran Chen, Jianwen Luo
Elastography provides tissue mechanical information to differentiate normal and disease states. Nowadays, axial displacement and strain are usually estimated in clinical practice whereas lateral estimation is rarely used given that its accuracy is typically one order of magnitude worse than that of axial estimation. To improve the performance of lateral estimation, spatial angular compounding of multiple axial displacements along ultrasound beams transmitting in different steering angles was previously proposed...
August 18, 2016: Ultrasonics
Rebecca L Stephens, Maura Sabatos-DeVito, J Steven Reznick
Individual differences in early attention are associated with later social, cognitive, and emotional development, and attentional deficits in the first year are associated with risk for developmental disorders such as Autism Spectrum Disorder (ASD). The First Year Inventory (FYI; Baranek, Watson, Crais, & Reznick, 2003) was developed to identify 12-month-olds at risk for an ASD diagnosis. The current study identifies FYI items that reflect aspects of early attention that might predict future typical and atypical social, cognitive, and emotional development...
August 8, 2016: Psychological Assessment
Raisa Z Freidlin, Harsh K Agarwal, Sandeep Sankineni, Anna M Brown, Francesca Mertan, Marcelino Bernardo, Dagane Daar, Maria Merino, Deborah Citrin, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
PURPOSE: The aim of this proof-of-concept work is to propose an unsupervised framework that combines multiple parameters, in "positive-if-all-positive" manner, from different models to localize tumors. METHODS: A voxel-by-voxel analysis of the DW-MRI images of whole prostate was performed to obtain parametric maps for D*, D, f, and K using the IVIM and kurtosis models. Ten patients with moderate or high-risk prostate cancer were included in study. The mean age and serum PSA for these 10 patients were 65years (range 54-78) and 21...
November 2016: Magnetic Resonance Imaging
Alyssa M Tutunjian, Nikolay Bugaev, Janis L Breeze, Sandra S Arabian, Reuven Rabinovici
BACKGROUND: Given potential safety risks when admitting injured patients to nonsurgical services (NSS), the American College of Surgeons mandates trauma centers justification. However, evidence supporting this requirement is lacking. METHODS: Adult patients cleared for admission to a NSS at a level 1 trauma center between 2012 and 2014 were retrospectively reviewed. Patient demographic, injury, and outcome characteristics were compared between nonsurgical (NSA) and surgical admission patients and analyzed for predictive value...
June 14, 2016: American Journal of Surgery
Alexander I Ivannikov, Artem M Khailov, Sergey P Orlenko, Valeri G Skvortsov, Valeri F Stepanenko, Kassym Sh Zhumadilov, Benjamin B Williams, Ann B Flood, Harold M Swartz
The aim of the study is to determine the average intensity and variation of the native background signal amplitude (NSA) and of the solar light-induced signal amplitude (LSA) in electron paramagnetic resonance (EPR) spectra of tooth enamel for different kinds of teeth and different groups of people. These values are necessary for determination of the intensity of the radiation-induced signal amplitude (RSA) by subtraction of the expected NSA and LSA from the total signal amplitude measured in L-band for in vivo EPR dosimetry...
July 13, 2016: Radiation Protection Dosimetry
Esmaeil Alizadeh, Nader Meskin, Khashayar Khorasani
High operational and maintenance costs represent as major economic constraints in the wind turbine (WT) industry. These concerns have made investigation into fault diagnosis of WT systems an extremely important and active area of research. In this paper, an immune system (IS) inspired methodology for performing fault detection and isolation (FDI) of a WT system is proposed and developed. The proposed scheme is based on a self nonself discrimination paradigm of a biological IS. Specifically, the negative selection mechanism [negative selection algorithm (NSA)] of the human body is utilized...
June 30, 2016: IEEE Transactions on Cybernetics
A Tucker, O Diamond, S McDonald, A Johnston, M Neil, D Kealey, P Archbold
INTRODUCTION: The Variable angle Martin Plate (MP) is designed to offer patient-specific adaption for the treatment of intertrochanteric hip fractures. Its proposed benefits include optimization of lag screw placement, plate shaft congruence and reduced risk of failure. Often its use has been criticized as representing a poor reduction of the fracture. The purpose of this study was to assess for a poorer quality of reduction, and compare functional outcomes and mortality, using a MP to that of a fixed angle Dynamic Hip Screw (DHS) in a matched cohort of patients...
June 11, 2016: Injury
Jae Young Park, Young Choi, Byung Chae Cho, Sang Young Moon, Chin Youb Chung, Kyoung Min Lee, Ki Hyuk Sung, Soon-Sun Kwon, Moon Seok Park
Progression of hip displacement is common in patients with cerebral palsy (CP). We aimed to investigate the rate of progression of hip displacement in patients with CP by assessing changes in radiographic indices according to Gross Motor Function Classification System (GMFCS) level during hip surveillance. We analyzed the medical records of patients with CP aged < 20 years who underwent at least 6 months interval of serial hip radiographs before any surgical hip intervention, including reconstructive surgery...
July 2016: Journal of Korean Medical Science
Kerstin Reidy, Christoph Heidt, Stefan Dierauer, Hanspeter Huber
BACKGROUND: Hip reconstructive surgery in cerebral palsy (CP) patients necessitates either femoral varus derotational osteotomy (VDRO) or pelvic osteotomy, or both. The purpose of this study is to review the results of a moderate varisation [planned neck shaft angle (NSA) of 130°] in combination with pelvic osteotomy for a consecutive series of patients. METHODS: Patients with CP who had been treated at our institution for hip dysplasia, subluxation or dislocation with VDRO in combination with pelvic osteotomy between 2005 and 2010 were reviewed...
August 2016: Journal of Children's Orthopaedics
Devendra Pathrot, Rehan Ul Haq, Aditya N Aggarwal, Mahindra Nagar, Shuchi Bhatt
BACKGROUND: Intramedullary devices have increasingly become popular and are widely used for fixation of unstable intertrochanteric and subtrochanteric fractures. These implants have been designed taking into consideration of the anthropometry of the western population which varies from those of other ethnic groups. This study was carried out to assess the geometry of proximal femur for the placement of short cephalomedullary nails in our subset of patients and suggest suitable design modifications based on these parameters...
May 2016: Indian Journal of Orthopaedics
David W Roberts, Yavuz Saglam, Adriana De La Rocha, Brigid N Frasquillo, Kirsten Tulchin-Francis, Harry K W Kim
BACKGROUND: Congenital coxa vara (CCV) is a rare hip condition with few long-term studies. The purpose of this study was to assess clinical, radiographic, and functional outcomes after operative and nonoperative treatment of CCV, assess reliability of radiographic parameters, and investigate risk factors for recurrence after surgery. METHODS: Retrospective review was performed of all CCV patients treated at 1 institution from 1980 to 2010. In addition, patients were recalled for additional follow-up x-rays, modified Harris Hip Score (mHHS), and gait analysis...
June 2, 2016: Journal of Pediatric Orthopedics
Jun Yuan, Yu Wu, Ji-yong Li, Xi Chen, Li Zhang, Yu-feng Liu, Sheng-xiong Tong, Fang-fang Deng
OBJECTIVE: To explore the effect of dexmedetomidine combined electrical stimulation on cognitive function of neurosurgical diseases patients treated by extracerebral intervention. METHODS: Totally 122 patients with neurosurgical diseases who underwent selective intervention were randomly assigned to the observation group and the control group, 61 cases in each group. Patients in the control group recieved anesthesia by dexmedetomidine. Those in the observation group received electrical stimulation at Baihui (DU20), Yintang ( EX-HN3), and Neiguan (PC6) before dexmedetomidine anesthesia...
March 2016: Chinese Journal of Integrated Traditional and Western Medicine
Sarah Meyer, Nele De Bruyn, Lena Krumlinde-Sundholm, Andre Peeters, Hilde Feys, Vincent Thijs, Geert Verheyden
BACKGROUND AND PURPOSE: Longitudinal information regarding the prevalence of upper limb somatosensory deficits and the association with motor impairment and activity limitations is scarce. The aim of this prospective cohort study was to map the extent and distribution of somatosensory deficits, and to determine associations over time between somatosensory deficits and motor impairment and activity limitations. METHODS: We recruited 32 participants who were assessed 4 to 7 days after stroke, and reassessed at 6 months...
July 2016: Journal of Neurologic Physical Therapy: JNPT
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