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https://www.readbyqxmd.com/read/28717369/association-of-irritable-bowel-syndrome-and-sleep-apnea-in-patients-referred-to-sleep-laboratory
#1
Farzin Ghiasi, Babak Amra, Vahid Sebghatollahi, Fatemeh Azimian
BACKGROUND: Irritable bowel syndrome (IBS) is assumed as one of the most frequent gastrointestinal disorders, which decreases the patient's quality of life. IBS pathogenesis, however, is not clearly defined. It seems that sleep apnea induces or escalates IBS clinical symptoms. This study aims at evaluating of IBS prevalence in patients, who are afflicted or are not afflicted with sleep apnea. MATERIALS AND METHODS: This was a case-control study, which was implemented in a sleep laboratory located in Isfahan, Iran...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28716527/identification-of-a-synergistic-combination-of-smac-mimetic-and-bortezomib-to-trigger-cell-death-in-b-cell-non-hodgkin-lymphoma-cells
#2
Irfan Ahmed Bhatti, Behnaz Ahangarian Abhari, Simone Fulda
Recently, copy number gains and increased expression levels of cIAP1 and cIAP2 have been reported in B-cell non-Hodgkin lymphomas (NHL). Therefore, we investigated the therapeutic potential of the Smac mimetic BV6 that antagonizes cIAP1/2 and XIAP. Here, we discover that subtoxic concentrations of BV6 prime B-cell NHL cells to proteasome inhibitor Bortezomib-induced cell death. Synergistic induction of cell death by BV6 and Bortezomib is confirmed by calculation of combination index in different cell lines, emphasizing the broader relevance of this combination...
July 14, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28639152/influence-of-muscle-groups-activation-on-proximal-femoral-growth-tendency
#3
Priti Yadav, Sandra J Shefelbine, Eva Pontén, Elena M Gutierrez-Farewik
Muscle and joint contact force influence stresses at the proximal growth plate of the femur and thus bone growth, affecting the neck shaft angle (NSA) and femoral anteversion (FA). This study aims to illustrate how different muscle groups' activation during gait affects NSA and FA development in able-bodied children. Subject-specific femur models were developed for three able-bodied children (ages 6, 7, and 11 years) using magnetic resonance images. Contributions of different muscle groups-hip flexors, hip extensors, hip adductors, hip abductors, and knee extensors-to overall hip contact force were computed...
June 22, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28607651/assessment-of-the-diagnostic-accuracy-of-double-inversion-recovery-sequence-compared-with-flair-and-t2w_tse-in-detection-of-cerebral-multiple-sclerosis-lesions
#4
Zahra Abidi, Fariborz Faeghi, Zahra Mardanshahi, Hasan Mortazavi
BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. MRI has an important role in early diagnosis of MS within diagnostic criteria. AIM: To determine the diagnostic value of the double inversion recovery (DIR) sequence in detection of brain MS lesions. METHODS: In this cross-sectional study, 55 patients were admitted to the MRI department in Vali-E-Asr Hospital in Qaemshahr, Iran, from May 2016 to February 2016...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28589290/validation-of-a-single-summary-score-for-the-prolapse-incontinence-sexual-questionnaire-iuga-revised-pisq-ir
#5
Melissa L Constantine, Rachel N Pauls, Rebecca R Rogers, Todd H Rockwood
INTRODUCTION AND HYPOTHESIS: The Prolapse/Incontinence Sexual Questionnaire-International Urogynecology Association (IUGA) Revised (PISQ-IR) measures sexual function in women with pelvic floor disorders (PFDs) yet is unwieldy, with six individual subscale scores for sexually active women and four for women who are not. We hypothesized that a valid and responsive summary score could be created for the PISQ-IR. METHODS: Item response data from participating women who completed a revised version of the PISQ-IR at three clinical sites were used to generate item weights using a magnitude estimation (ME) and Q-sort (Q) approaches...
June 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28585457/effect-of-geometric-parameters-in-the-design-of-customized-hip-implants
#6
Mangesh Dharme, Abhaykumar Kuthe
In this paper, the effects of geometric parameters on the development of stress in custom cementless hip implant have been studied. Taguchi methods and analysis of variance (ANOVA) were used to find out which geometric parameters are statistically significant for the maximum von Mises stresses in the hip implant. The multiple regression analysis was also performed, to replace the FE solver and accurately and quickly predict the stress values for new patients. Three parameters horizontal offset (HO), vertical offset and neck shaft angle (NSA), with three levels have been selected...
June 6, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28560796/postoperative-evaluation-of-reduction-loss-in-proximal-humeral-fractures-a-comparison-of-plain-radiographs-and-computed-tomography
#7
Xiao-Yang Jia, Yan-Xi Chen, Min-Fei Qiang, Kun Zhang, Hao-Bo Li, Yu-Chen Jiang, Yi-Jie Zhang
OBJECTIVE: To compare postoperative CT images with plain radiographs for measuring prognostic factors of reduction loss of fractures of the proximal part of the humerus. METHODS: A total of 65 patients who sustained fractures of the proximal humerus treated with locking plates from June 2012 to October 2015 were retrospectively analyzed. There were 24 men and 41 women, with a mean age of 60.0 years (range, 22-76 years). According to the Neer classification system of proximal humeral fracture, there were 26 two-part, 27 three-part and 12 four-part fractures of the proximal part of the humerus, and all fractures were treated with open reduction and internal fixation (ORIF) using locked plating...
May 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28529944/optimization-of-time-for-neural-stem-cells-transplantation-for-brain-stroke-in-rats
#8
Seyyed Mohyeddin Ziaee, Parisa Tabeshmehr, Khawaja Husnain Haider, Majidreza Farrokhi, Abdolhamid Shariat, Atena Amiri, Seyed Mojtaba Hosseini
BACKGROUND: Despite encouraging data in terms of neurological outcome, stem cell based therapy for ischemic stroke in experimental models and human patients is still hampered by multiple as yet un-optimized variables, i.e., time of intervention, that significantly influence the prognosis. The aim of the present study was to delineate the optimum time for neural stem cells (NSCs) transplantation after ischemic stroke. METHODS: The NSCs were isolated from 14 days embryo rat ganglion eminence and were cultured in NSA medium (neurobasal medium, 2% B27, 1% N2, bFGF 10 ng/mL, EGF 20 ng/mL and 1% pen/strep)...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28500940/efficient-catalytic-hydration-of-cyanamides-in-aqueous-medium-and-in-the-presence-of-naringin-sulfuric-acid-or-green-synthesized-silver-nanoparticles-by-using-gongronema-latifolium-leaf-extract
#9
Zahra Issaabadi, Mahmoud Nasrollahzadeh, S Mohammad Sajadi
In this paper, a novel, efficient and green method for the preparation of Naringin sulfuric acid (NSA) as a Brønsted acid organocatalyst and silver nanoparticles (Ag NPs) by using Gongronema latifolium leaf extract as a reducing and stabilizing agent is introduced. The catalysts were characterized using the powder XRD, SEM, EDS, TEM, UV-Vis and FT-IR spectroscopy. Afterward, the catalytic activity of synthesized NSA and Ag NPs were investigated for the synthesis of N-monosubstituted ureas via the hydration of cyanamides in aqueous medium...
October 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28499398/biomechanical-evaluation-of-a-novel-dualplate-fixation-method-for-proximal-humeral-fractures-without-medial-support
#10
Yu He, Yaoshen Zhang, Yan Wang, Dongsheng Zhou, Fu Wang
BACKGROUND: Comminuted fractures of the proximal humerus are generally treated with the locking plate system, and clinical results are satisfactory. However, unstable support of the medial column results in varus malunion and screw perforation. We designed a novel medial anatomical locking plate (MLP) to directly support the medial column. Theoretically, the combined application of locking plate and MLP (LPMP) would directly provide strong dual-column stability. We hypothesized that the LPMP could provide greater construct stability than the locking plate alone (LP), locking plate combined with a fibular graft (LPSG), and locking plate combined with a distal radius plate (LPDP)...
May 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28464594/-analysis-on-the-performance-evaluation-of-the-global-fund-malaria-programme-in-china-from-2003-to-2013
#11
Q F Zhang, R B Wang, B Zheng, Z G Xia, S S Zhou
Objective: To analyze the performance of the 5 Global Fund Malaria Programmes in China from 2003 to 2013. Methods: All of the proposals, summaries, progress reports, survey reports, Monitoring& Evaluation reports, and performance rating reports of the 5 Global Fund Malaria Programmes in China and the epidemic data of program areas were collected for statistical analysis from 2012 to 2014. Symposiums were held with relevant experts from national and provincial Centers for Disease Control and Prevention, program managers and staffs from national and provincial Global Fund Malaria Programme offices...
May 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28461299/th-2-signature-in-chronic-airway-diseases-towards-the-extinction-of-asthma-copd-overlap-syndrome
#12
Borja G Cosío, Luis Pérez de Llano, Antolin Lopez Viña, Alfons Torrego, Jose Luis Lopez-Campos, Joan B Soriano, Eva Martinez Moragon, Jose Luis Izquierdo, Irina Bobolea, Javier Callejas, Vicente Plaza, Marc Miravitlles, Juan Jose Soler-Catalunya
We aimed to describe the differences and similarities between patients with chronic obstructive airway disease classified on the basis of classical diagnostic labels (asthma, chronic obstructive pulmonary disease (COPD), or asthma-COPD overlap (ACOS)) or according to the underlying inflammatory pattern (Th-2 signature, either Th-2-high or Th-2-low).We performed a cross-sectional study of patients aged ≥40 years and with a post-bronchodilator forced expiratory volume in 1 s to forced vital capacity ratio ≤0...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28445878/differential-allelic-expression-of-htr1b-in-suicide-victims-genetic-and-epigenetic-effect-of-the-cis-acting-variants
#13
Ali Bani-Fatemi, Aaron Howe, Clement Zai, James L Kennedy, John Vincent, John Strauss, Albert Wong, Vincenzo De Luca
OBJECTIVES: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. METHODS: The study was conducted using 3 sets of samples. First, C861G allele-specific mRNA levels in the frontal cortex were compared between suicide (n = 13) and nonsuicide controls (n = 13) from the Stanley Medical Research postmortem brain collection. Second, we tested common variants in the HTR1B promoter for linkage disequilibrium (LD) with the C861G variant in an unrelated sample of suicide attempters (SA; n = 38) and non-SA (NSA; n = 42)...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28438550/lipophilic-salts-of-poorly-soluble-compounds-to-enable-high-dose-lipidic-sedds-formulations-in-drug-discovery
#14
Michael Morgen, Ajay Saxena, Xue-Qing Chen, Warren Miller, Richard Nkansah, Aaron Goodwin, Jon Cape, Roy Haskell, Ching Su, Olafur Gudmundsson, Michael Hageman, Anoop Kumar, Gajendra Singh Chowan, Abhijith Rao, Vinay K Holenarsipur
Self-emulsifying drug delivery systems (SEDDS) have been used to solubilize poorly water-soluble drugs to improve exposure in high-dose pharmacokinetic (PK) and toxicokinetic (TK) studies. However, the absorbable dose is often limited by drug solubility in the lipidic SEDDS vehicle. This study focuses on increasing solubility and drug loading of ionizable drugs in SEDDS vehicles using lipophilic counterions to prepare lipophilic salts of drugs. SEDDS formulations of two lipophilic salts-atazanavir-2-naphthalene sulfonic acid (ATV-2-NSA) and atazanavir-dioctyl sulfosuccinic acid (ATV-Doc)-were characterized and their performance compared to atazanavir (ATV) free base formulated as an aqueous crystalline suspension, an organic solution, and a SEDDS suspension, using in vitro, in vivo, and in silico methods...
April 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28400660/anthropometric-analysis-of-the-hip-joint-in-south-indian-population-using-computed-tomography
#15
Vetrivel Chezian Sengodan, Elangovan Sinmayanantham, J Saravana Kumar
BACKGROUND: Proximal femur has a significant functional modification on erect bipedal posture. Various proximal femoral parameters were analyzed in Western literature. This information was utilized in prosthetic designing. Implants designed for Western people are used in Indian patients undergoing hip surgeries such as internal fixation and replacement arthroplasty. MATERIALS AND METHODS: The study was done among 200 individuals (400 hips) with a normal hip joint after ethical committee clearance...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28389782/spanish-version-of-the-pelvic-organ-prolapse-urinary-incontinence-sexual-questionnaire%C3%A2-iuga-revised-pisq-ir-%C3%A2-transcultural-validation
#16
Montserrat Mestre, Judith Lleberia, Josep Pubill, Montserrat Espuña-Pons
INTRODUCTION AND HYPOTHESIS: The aim of this study was to transculturally adapt the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire IUGA-Revised (PISQ-IR) into Spanish and to validate the new version. METHODS: We carried out a two-stage observational cross-sectional study: translation and back-translation, followed by a validation stage in which the final version was administered to 268 consecutive women (118 not sexually active [NSA] and 150 sexually active [SA]) older than 18 from an Urogynecology Unit...
April 8, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28376893/effects-of-socio-demographic-characteristics-and-household-water-management-on-aedes-aegypti-production-in-suburban-and-rural-villages-in-laos-and-thailand
#17
Nanthasane Vannavong, Razak Seidu, Thor-Axel Stenström, Nsa Dada, Hans J Overgaard
BACKGROUND: Dengue fever is a mosquito-borne disease accounting for 50-100 million annual cases globally. Laos and Thailand are countries in south-east Asia where the disease is endemic in both urban and rural areas. Household water storage containers, which are favourable breeding sites for dengue mosquitoes, are common in these areas, due to intermittent or limited access to water supply. This study assessed the effect of household water management and socio-demographic risk factors on Aedes aegypti infestation of water storage containers...
April 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28322028/localization-of-nucleoside-transporters-in-rat-epididymis
#18
David M Klein, Marcus C Harding, Meghan K Crowther, Nathan J Cherrington
The epididymis relies on transporters for the secretion of nucleosides and influence the disposition of nucleoside analogs (NSA). Since these compounds can cross the blood-testis barrier (BTB), it is important to understand if the epididymis reabsorbs NSA drugs. The purpose of this study is to determine the localization of nucleoside transporters expressed within rat epididymis to demonstrate the potential of epididymal reabsorption. Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the nucleus of the epithelium and CNT2 is expressed by basal cells...
March 21, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28321452/spontaneous-wormlike-micelles-formed-in-a-single-tailed-zwitterionic-surface-active-ionic-liquid-aqueous-solution
#19
Panpan Sun, Fei Lu, Aoli Wu, Lijuan Shi, Liqiang Zheng
Wormlike micelles were successfully fabricated by the self-assembly of a single-tailed zwitterionic surface-active ionic liquid (SAIL), 3-(1-hexadecyl-3-imidazolio) propanesulfonate β-naphthalene sulfonate (C16IPS-Nsa), in aqueous solutions without any additives. With increasing zwitterionic SAIL concentration, spontaneous transition from micelles to wormlike micelles and then a hexagonal phase occurs. Interestingly, the wormlike micelles are closed, stretched and directionally arranged, which was rarely found in previous research studies...
March 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28289909/ripk1-ripk3-mlkl-mediated-necroptosis-contributes-to-compression-induced-rat-nucleus-pulposus-cells-death
#20
Songfeng Chen, Xiao Lv, Binwu Hu, Zengwu Shao, Baichuan Wang, Kaige Ma, Hui Lin, Min Cui
The aim of this study was to systematically investigate the role of necroptosis in compression-induced rat nucleus pulposus (NP) cells death, as well as explore the underlying mechanisms involved. Rat NP cells underwent various periods of exposure to 1.0 MPa pressure. Cell viability and cell death were quantified by using cell counting kit-8 (CCK-8), and Calcein-AM/propidium iodine (PI) staining respectively. Necroptosis-associated target molecules receptor-interacing protein kinase 1 (RIPK1), phosphorylated RIPK1 (pRIPK1), receptor-interacing protein kinase 3 (RIPK3), phosphorylated RIPK3 (pRIPK3) and mixed lineage kinase domain-like (MLKL) were analyzed by Western-blot and RT-PCR...
March 13, 2017: Apoptosis: An International Journal on Programmed Cell Death
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