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https://www.readbyqxmd.com/read/29667827/in-situ-x-ray-diffraction-study-of-the-thermal-decomposition-of-selenogallates-cs-2-ga-2-se-2-2-x-se-2-x-x-0-1-2
#1
Daniel Friedrich, Marc Schlosser, Christian Näther, Arno Pfitzner
The selenogallates CsGaSe3 and Cs2 Ga2 Se5 release gaseous selenium upon heating. An in situ high-temperature X-ray powder diffraction analysis revealed a two-step degradation process from CsGaSe3 to Cs2 Ga2 Se5 and finally to CsGaSe2 . During each step, one Se2 2- unit of the anionic chains in Cs2 [Ga2 (Se2 )2- x Se2+ x ] ( x = 0, 1, 2) decomposes, and one equivalent of selenium is released. This thermal decomposition can be reverted by simple addition of elemental selenium and subsequent annealing of the samples below the decomposition temperature...
April 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29667529/emerging-therapeutic-targets-for-neurofibromatosis-type-1
#2
James A Walker, Meena Upadhyaya
Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited tumor predisposition syndrome with an incidence of one in 3000-4000 individuals with no currently effective therapies. The NF1 gene on chromosome 17 encodes neurofibromin, which functions as a negative regulator of RAS. NF1 is a chronic multi-system disorder affecting many different tissues. Due to cell-specific complexities of RAS signaling, therapeutic approaches for NF1 will likely have to focus on a particular tissue and manifestation of the disease...
April 18, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29667293/enhanced-in-vitro-biocompatibility-and-water-dispersibility-of-magnetite-and-cobalt-ferrite-nanoparticles-employed-as-ros-formation-enhancer-in-radiation-cancer-therapy
#3
Stefanie Klein, Melek Kızaloğlu, Luis Portilla, Hyoungwon Park, Tobias Rejek, Julian Hümmer, Karsten Meyer, Rainer Hock, Luitpold V R Distel, Marcus Halik, Carola Kryschi
Efficient magnetic reactive oxygen species (ROS) formation enhancing agents after X-ray treatment are realized by functionalizing superparamagnetic magnetite (Fe3 O4 ) and Co-ferrite (CoFe2 O4 ) nanoparticles with self-assembled monolayers (SAMs). The Fe3 O4 and CoFe2 O4 nanoparticles are synthesized using Massart's coprecipitation technique. Successful surface modification with the SAM forming compounds 1-methyl-3-(dodecylphosphonic acid) imidazolium bromide, or (2-{2-[2-hydroxy-ethoxy]-ethoxy}-ethyl phosphonic acid provides biocompatibility and long-term stability of the Fe3 O4 and CoFe2 O4 nanoparticles in cell media...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667125/parallel-exhaustive-processing-underlies-logarithmic-search-functions-visual-search-with-cortical-magnification
#4
Zhiyuan Wang, Alejandro Lleras, Simona Buetti
Our lab recently found evidence that efficient visual search (with a fixed target) is characterized by logarithmic Reaction Time (RT) × Set Size functions whose steepness is modulated by the similarity between target and distractors. To determine whether this pattern of results was based on low-level visual factors uncontrolled by previous experiments, we minimized the possibility of crowding effects in the display, compensated for the cortical magnification factor by magnifying search items based on their eccentricity, and compared search performance on such displays to performance on displays without magnification compensation...
April 17, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29666956/early-postnatal-development-of-the-lamination-in-the-lateral-geniculate-nucleus-a-layers-in-cats
#5
Natalia Merkulyeva, Aleksandr Mikhalkin, Pavel Zykin
The early postnatal development of the A-layers of the dorsal lateral geniculate nucleus (LGNd) was investigated in kittens aged 0-34 days by immunohistochemistry for the selective marker for neuronal differentiation (NeuN protein) and parvalbumin. We report two new facts about the LGNd development. First, there is a transient stratification of NeuN labelling in layer A, and to a lesser extent in layer A1, in kittens aged 0 and 4 days. Second, a transient population of large cells that are located between the LGNd A-layers (interlaminar cells) showed high expression levels of both NeuN and parvalbumin...
April 17, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29666851/quantum-oscillation-in-carrier-transport-in-two-dimensional-junctions
#6
Junfeng Zhang, Weiyu Xie, Michael L Agiorgousis, Duk-Hyun Choe, Vincent Meunier, Xiaohong Xu, Jijun Zhao, Shengbai Zhang
Two-dimensional (2D) junction devices have recently attracted considerable attention. Here, we show that most 2D junction structures, whether vertical or lateral, act as a lateral monolayer-bilayer-monolayer junction in their operation. In particular, a vertical structure cannot function as a vertical junction as having been widely believed in the literature. Due to a larger electrostatic screening, the bilayer region in the junction always has a smaller bandgap than its monolayer counterpart. As a result, a potential well, aside from the usual potential barrier, will form universally in the bilayer region to affect the hole or electron quantum transport in the form of transmission or reflection...
April 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29666780/identification-expression-analysis-and-molecular-modeling-of-iron-deficiency-specific-clone-3-ids3-like-gene-in-hexaploid-wheat
#7
Priyanka Mathpal, Upendra Kumar, Anuj Kumar, Sanjay Kumar, Sachin Malik, Naveen Kumar, H S Dhaliwal, Sundip Kumar
Graminaceous plants secrete hydroxylated phytosiderophores encoded by the genes iron-deficiency-specific clone 2 ( Ids2 ) and iron-deficiency-specific clone 3 ( Ids3 ). An effort was made to identify a putative ortholog of Hodeum vulgare Ids3 gene in hexaploid wheat. The protein structure of TaIDS3 was modeled using homology modeling and structural behavior of modeled structure was analyzed at 20 ns. The simulation trajectory using molecular dynamics simulation suggested the model to be stable with no large fluctuations in residues and local domain level RMSF values (< 2...
April 2018: 3 Biotech
https://www.readbyqxmd.com/read/29666769/joint-level-energetics-differentiate-isoinertial-from-speed-power-resistance-training-a-bayesian-analysis
#8
Bernard X W Liew, Christopher C Drovandi, Samuel Clifford, Justin W L Keogh, Susan Morris, Kevin Netto
Background: There is convincing evidence for the benefits of resistance training on vertical jump improvements, but little evidence to guide optimal training prescription. The inability to detect small between modality effects may partially reflect the use of ANOVA statistics. This study represents the results of a sub-study from a larger project investigating the effects of two resistance training methods on load carriage running energetics. Bayesian statistics were used to compare the effectiveness of isoinertial resistance against speed-power training to change countermovement jump (CMJ) and squat jump (SJ) height, and joint energetics...
2018: PeerJ
https://www.readbyqxmd.com/read/29666472/caspase-8-deficiency-in-mouse-embryos-triggers-chronic-ripk1-dependent-activation-of-inflammatory-genes-independently-of-ripk3
#9
Tae-Bong Kang, Ju-Seong Jeong, Seung-Hoon Yang, Andrew Kovalenko, David Wallach
Deletion of the Casp8 gene in epithelial tissues of mice results in severe inflammatory pathologies. Its ubiquitous deletion, or its specific deletion in endothelial cells, results in intrauterine death associated with capillary damage. These pathologies are all preventable by co-deletion of Casp8 and the genes encoding either the RIPK1 or the RIPK3 protein kinase. Since activation of RIPK3 in Caspase-8-deficient cells can trigger necroptotic cell death, and since RIPK1 can activate RIPK3, it is widely assumed that the inflammatory states resulting from Caspase-8 deficiency occur as a consequence of RIPK3-induced necroptosis...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29666377/potential-reporting-bias-in-neuroimaging-studies-of-sex-differences
#10
Sean P David, Florian Naudet, Jennifer Laude, Joaquim Radua, Paolo Fusar-Poli, Isabella Chu, Marcia L Stefanick, John P A Ioannidis
Numerous functional magnetic resonance imaging (fMRI) studies have reported sex differences. To empirically evaluate for evidence of excessive significance bias in this literature, we searched for published fMRI studies of human brain to evaluate sex differences, regardless of the topic investigated, in Medline and Scopus over 10 years. We analyzed the prevalence of conclusions in favor of sex differences and the correlation between study sample sizes and number of significant foci identified. In the absence of bias, larger studies (better powered) should identify a larger number of significant foci...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666365/unifying-the-global-phylogeny-and-environmental-distribution-of-ammonia-oxidising-archaea-based-on-amoa-genes
#11
Ricardo J Eloy Alves, Bui Quang Minh, Tim Urich, Arndt von Haeseler, Christa Schleper
Ammonia-oxidising archaea (AOA) are ubiquitous and abundant in nature and play a major role in nitrogen cycling. AOA have been studied intensively based on the amoA gene (encoding ammonia monooxygenase subunit A), making it the most sequenced functional marker gene. Here, based on extensive phylogenetic and meta-data analyses of 33,378 curated archaeal amoA sequences, we define a highly resolved taxonomy and uncover global environmental patterns that challenge many earlier generalisations. Particularly, we show: (i) the global frequency of AOA is extremely uneven, with few clades dominating AOA diversity in most ecosystems; (ii) characterised AOA do not represent most predominant clades in nature, including soils and oceans; (iii) the functional role of the most prevalent environmental AOA clade remains unclear; and (iv) AOA harbour molecular signatures that possibly reflect phenotypic traits...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29666271/desynchronization-of-slow-oscillations-in-the-basal-ganglia-during-natural-sleep
#12
Aviv D Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Hagai Bergman
Slow oscillations of neuronal activity alternating between firing and silence are a hallmark of slow-wave sleep (SWS). These oscillations reflect the default activity present in all mammalian species, and are ubiquitous to anesthesia, brain slice preparations, and neuronal cultures. In all these cases, neuronal firing is highly synchronous within local circuits, suggesting that oscillation-synchronization coupling may be a governing principle of sleep physiology regardless of anatomical connectivity. To investigate whether this principle applies to overall brain organization, we recorded the activity of individual neurons from basal ganglia (BG) structures and the thalamocortical (TC) network over 70 full nights of natural sleep in two vervet monkeys...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666262/spatial-and-temporal-heterogeneity-of-neural-responses-in-human-posteromedial-cortex
#13
Amy L Daitch, Josef Parvizi
Neuroimaging evidence supports a role of the default mode network (DMN) in spontaneous thought and goal-driven internally oriented processes, such as recalling an autobiographical event, and has demonstrated its deactivation during focused, externally oriented attention. Recent work suggests that the DMN is not a homogeneous network but rather is composed of at least several subnetworks, which are engaged in distinct functions; however, it is still unclear if these different functions rely on the same neuronal populations...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666071/b-type-natriuretic-peptide-assessment-in-patients-undergoing-revascularization-for-left-main-coronary-artery-disease-analysis-from-the-excel-trial
#14
Björn Redfors, Shmuel Chen, Aaron Crowley, Ori Ben-Yehuda, Bernard J Gersh, Nicholas J Lembo, W Morris Brown, Adrian P Banning, David P Taggart, Patrick W Serruys, Arie Pieter Kappetein, Joseph F Sabik, Gregg W Stone
Background -Elevated B-type natriuretic peptide (BNP) is reflective of impaired cardiac function and is associated with worse prognosis among patients with coronary artery disease (CAD). We sought to assess the association between baseline BNP, adverse outcomes, and the relative efficacy of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) in patients with left main (LM) CAD. Methods -The EXCEL trial randomized patients with LMCAD and low or intermediate SYNTAX scores to PCI with everolimus-eluting stents versus CABG...
April 17, 2018: Circulation
https://www.readbyqxmd.com/read/29665880/post-operative-course-prediction-during-endoscopic-sinus-surgery-in-patients-with-chronic-rhinosinusitis
#15
K Tsuzuki, K Hashimoto, K Okazaki, M Sakagami
OBJECTIVE: This study aimed to analyse findings of functional endoscopic sinus surgery to estimate the post-operative course of patients with chronic rhinosinusitis. METHODS: From 2007 to 2015, 291 adult patients with bilateral chronic rhinosinusitis, divided into eosinophilic chronic rhinosinusitis (n = 210) and non-eosinophilic chronic rhinosinusitis (n = 81) groups, who underwent primary functional endoscopic sinus surgery were enrolled. Functional endoscopic sinus surgery findings, scored as operating score, were analysed in relation to pre-operative olfactory recognition threshold and sinonasal computed tomography imaging score, as well as post-operative endoscopic appearance...
April 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29665821/plasma-proteomic-analysis-reveals-altered-protein-abundances-in-cardiovascular-disease
#16
Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak, Antonia Vlahou
BACKGROUND: Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To this end, we performed a comprehensive proteomic analysis of blood plasma, with the scope to identify disease-associated changes after placing them in the context of existing knowledge, and generate a well characterized dataset for further use in CVD multi-omics integrative analysis...
April 17, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29665773/identification-and-characterization-of-functional-modules-reflecting-transcriptome-transition-during-human-neuron-maturation
#17
Zhisong He, Qianhui Yu
BACKGROUND: Neuron maturation is a critical process in neurogenesis, during which neurons gain their morphological, electrophysiological and molecular characteristics for their functions as the central components of the nervous system. RESULTS: To better understand the molecular changes during this process, we combined the protein-protein interaction network and public single cell RNA-seq data of mature and immature neurons to identify functional modules relevant to the neuron maturation process in humans...
April 17, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29665713/a-clockwork-wikipedia-from-a-broad-perspective-to-a-case-study
#18
Omer Benjakob, Rona Aviram
While research has shown that scientists use Wikipedia and that scientific content on Wikipedia ramifies back into scientific literature, many questions remain on how the two sides interact and through what paradigm this dynamic may be best understood. Using the circadian clock field as a case study, we discuss this scientific field's representation on Wikipedia. We traced the changes made to the articles for "Circadian clock" and "Circadian rhythm" and reviewed the debates that informed them over a span of a decade, using Wikipedia's native and third-party tools...
April 1, 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29665226/tunable-spectrum-selectivity-for-multiphoton-absorption-with-enhanced-visible-light-trapping-in-zno-nanorods
#19
Kok Hong Tan, Fang Sheng Lim, Alfred Zhen Yang Toh, Xia-Xi Zheng, Chang Fu Dee, Burhanuddin Yeop Majlis, Siang-Piao Chai, Wei Sea Chang
Observation of visible light trapping in zinc oxide (ZnO) nanorods (NRs) correlated to the optical and photoelectrochemical properties is reported. In this study, ZnO NR diameter and c-axis length respond primarily at two different regions, UV and visible light, respectively. ZnO NR diameter exhibits UV absorption where large ZnO NR diameter area increases light absorption ability leading to high efficient electron-hole pair separation. On the other hand, ZnO NR c-axis length has a dominant effect in visible light resulting from a multiphoton absorption mechanism due to light reflection and trapping behavior in the free space between adjacent ZnO NRs...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29665127/proteomic-analysis-of-serum-and-sputum-analytes-distinguishes-controlled-and-poorly-controlled-asthmatics
#20
Marion T Kasaian, Julie Lee, Agnes Brennan, Spencer I Danto, Kendall E Black, Lori Fitz, Anne E Dixon
BACKGROUND: A major goal of asthma therapy is to achieve disease control, with maintenance of lung function, reduced need for rescue medication, and prevention of exacerbation. Despite current standard of care, up to 70% of patients with asthma remain poorly controlled. Analysis of serum and sputum biomarkers could offer insights into parameters associated with poor asthma control. OBJECTIVE: To identify signatures as determinants of asthma disease control, we performed proteomics using Olink proximity extension analysis...
April 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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