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Talitha Caldas Dos Santos, Nicoletta Rescignano, Laurita Boff, Flávio Henrique Reginatto, Cláudia Maria Oliveira Simões, Angela Machado de Campos, Carmen Mijangos
In this work is reported a novel and promising approach for the preparation of C-glycosylflavonoid enriched fraction of Cecropia glaziovii (EFF-Cg) loaded PLGA nanoparticles (NP) with antiherpes properties. The purpose of this study was to evaluate and to compare the effect of two nonionic surfactants (poloxamer 188 (PLU) and polyvinyl alcohol (PVA)), and also an emulsion stabilized by solid particles of cellulose nanocrystal (CNC) in place of surfactants. The characterization of these nanoparticles was in terms of size, polydispersity index, zeta potential, morphology, thermogravimetric analysis (TGA), loading capacity and percent yield...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Anne C Laurita, Cindy Hazan, R Nathan Spreng
The human brain tracks dynamic changes within the social environment, forming and updating representations of individuals in our social milieu. This mechanism of social navigation builds an increasingly complex map of persons with whom we are familiar and form attachments to guide adaptive social behaviors. We examined the neural representation of known others along a continuum of attachment using fMRI. Heterosexual adults (N = 29, 16 females), in romantic relationships for more than two years, made trait judgments for a romantic partner, parent, close friend, familiar acquaintance, and self during scanning...
April 12, 2017: Social Cognitive and Affective Neuroscience
Leo K Lamontagne, Geneva Laurita, Michael Knight, Huma Yusuf, Jerry Hu, Ram Seshadri, Katharine Page
The cubic semiconducting compounds APd3O4 (A = Ca, Sr) can be hole-doped by Na substitution on the A site and driven toward more conducting states. This process has been followed here by a number of experimental techniques to understand the evolution of electronic properties. While an insulator-to-metal transition is observed in Ca1-xNaxPd3O4 for x ≥ 0.15, bulk metallic behavior is not observed for Sr1-xNaxPd3O4 up to x = 0.20. Given the very similar crystal and (calculated) electronic structures of the two materials, the distinct behavior is a matter of interest...
April 13, 2017: Inorganic Chemistry
Drew M Nassal, Xiaoping Wan, Haiyan Liu, Kenneth R Laurita, Isabelle Deschênes
Pathologic electrical remodeling and attenuated cardiac contractility are featured characteristics of heart failure. Coinciding with these remodeling events is a loss of the K+ channel interacting protein, KChIP2. While, KChIP2 enhances the expression and stability of the Kv4 family of potassium channels, leading to a more pronounced transient outward K+ current, Ito,f, the guinea pig myocardium is unique in that Kv4 expression is absent, while KChIP2 expression is preserved, suggesting alternative consequences to KChIP2 loss...
2017: PloS One
Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S Moravec, Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes
Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in numerous cardiac pathologies. However, it remains unknown if KChIP2 loss is merely a symptom or involved in disease development. Using rat and human derived cardiomyocytes, we identify a previously unobserved transcriptional capacity for cardiac KChIP2 critical in maintaining electrical stability...
March 6, 2017: ELife
Clayton Cozzan, Kent J Griffith, Geneva Laurita, Jerry G Hu, Clare P Grey, Ram Seshadri
SiAlON ceramics, solid solutions based on the Si3N4 structure, are important, lightweight structural materials with intrinsically high strength, high hardness, and high thermal and chemical stability. Described by the chemical formula β-Si6-zAlzOzN8-z, from a compositional viewpoint, these materials can be regarded as solid solutions between Si3N4 and Al3O3N. A key aspect of the structural evolution with increasing Al and O (z in the formula) is to understand how these elements are distributed on the β-Si3N4 framework...
February 20, 2017: Inorganic Chemistry
Luciana Marques Paula, Luis Henrique Ferreira De Moraes, Abaeté Leite Do Canto, Laurita Dos Santos, Airton Abrahão Martin, Silvia Regina Rogatto, Renata De Azevedo Canevari
Nodal status is the most significant independent prognostic factor in breast cancer. Identification of molecular markers would allow stratification of patients who require surgical assessment of lymph nodes from the large numbers of patients for whom this surgical procedure is unnecessary, thus leading to a more accurate prognosis. However, up to now, the reported studies are preliminary and controversial, and although hundreds of markers have been assessed, few of them have been used in clinical practice for treatment or prognosis in breast cancer...
January 2017: Oncology Letters
Laurita Dos Santos, Claudio A Téllez S, Mariane P J Sousa, Nuno G Azoia, Artur M Cavaco-Paulo, Airton A Martin, Priscila P Favero
OBJECTIVE: The purpose of this study is to elucidate the behavior of retinyl acetate in penetrating human skin without the presence of enhancers by using confocal Raman spectroscopy and molecular dynamics simulation. METHODS: In this study, in vivo confocal Raman spectroscopy was combined with molecular dynamics simulation to investigate the transdermal permeation of the aqueous suspension of retinyl acetate. RESULTS: Permeation was measured after 30min, and retinyl acetate was found up to 20μm deep inside the stratum corneum...
March 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Rosanna Ciriello, Pina Teresa Iallorenzi, Alessandro Laurita, Antonio Guerrieri
A novel capillary zone electrophoresis (CZE) method was developed for an improved separation and size characterization of pristine gold nanoparticles (AuNP) using uncoated fused-silica capillaries with UV-Vis detection at 520 nm. To avoid colloid aggregation and/or adsorption during runs, poly(sodium 4-styrenesulfonate) (PSS) was added (1%, w/v) in the running buffer (CAPS 10 mM, pH 11). This polyelectrolyte conferred an enhanced stabilization to AuNP, both steric and electrostatic, exalting at the same time their differences in electrophoretic mobility...
March 2017: Electrophoresis
Lázaro Pinto Medeiros Neto, Luis Felipe das Chagas E Silva de Carvalho, Laurita Dos Santos, Cláudio Alberto Tellez Soto, Renata de Azevedo Canevari, André Bandiera de Oliveira Santos, Evandro Sobroza Mello, Marina Aparecida Pereira, Cláudio Roberto Cernea, Lenine Garcia Brandão, Aírton Abrahão Martin
Thyroid carcinomas are the most common endocrine malignancy. Inconclusive results for the analysis of malignancies are an issue in the diagnosis of thyroid carcinomas; 20% of thyroid cancer diagnoses are indeterminate or suspicious, resulting in a surgical procedure without immediate need. The use of Raman spectroscopy may help improve the diagnosis of thyroid carcinoma. In this study, 30 thyroid samples, including normal thyroid, goiter and thyroid cancer, were analyzed by confocal Raman spectroscopy. Principal component analysis (PCA), linear discriminant analysis (LDA) with cross validation and binary logistic regression (BLR) analysis were applied to discriminate among tissues...
December 5, 2016: Photodiagnosis and Photodynamic Therapy
Claudio Alberto Téllez Soto, Liliane Pereira, Laurita Dos Santos, Ramu Rajasekaran, Priscila Fávero, Airton Abrahão Martin
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
Douglas H Fabini, Constantinos C Stoumpos, Geneva Laurita, Andreas Kaltzoglou, Athanassios G Kontos, Polycarpos Falaras, Mercouri G Kanatzidis, Ram Seshadri
The structure of the hybrid perovskite HC(NH2 )2 PbI3 (formamidinium lead iodide) reflects competing interactions associated with molecular motion, hydrogen bonding tendencies, thermally activated soft octahedral rotations, and the propensity for the Pb(2+) lone pair to express its stereochemistry. High-resolution synchrotron X-ray powder diffraction reveals a continuous transition from the cubic α-phase (Pm3‾ m, #221) to a tetragonal β-phase (P4/mbm, #127) at around 285 K, followed by a first-order transition to a tetragonal γ-phase (retaining P4/mbm, #127) at 140 K...
November 10, 2016: Angewandte Chemie
Fernanda Kokowicz Pilatti, Fernanda Ramlov, Eder Carlos Schmidt, Christopher Costa, Eva Regina de Oliveira, Claudia M Bauer, Miguel Rocha, Zenilda Laurita Bouzon, Marcelo Maraschin
Fossil fuels, e.g. gasoline and diesel oil, account for substantial share of the pollution that affects marine ecosystems. Environmental metabolomics is an emerging field that may help unravel the effect of these xenobiotics on seaweeds and provide methodologies for biomonitoring coastal ecosystems. In the present study, FTIR and multivariate analysis were used to discriminate metabolic profiles of Ulva lactuca after in vitro exposure to diesel oil and gasoline, in combinations of concentrations (0.001%, 0...
January 30, 2017: Marine Pollution Bulletin
Angela De Bonis, Antonio Santagata, Agostino Galasso, Alessandro Laurita, Roberto Teghil
Laser ablation of bulk target in liquid allows to obtain stable nanoparticles and nanostructures, also in metastable phases, limiting the use of hazardous reagents and extreme reaction conditions. Titanium carbide (TiC) is a ceramic compound with several technological applications ranging from biocompatible materials to wear resistant coatings. The possibility to obtain core/shell structures expands its range of application due to the ability of modify the surface properties of the core ceramic material. TiC and metallic titanium targets have been ablated by means of an ultra-short laser source in different liquid media (water, acetone, n-hexane and toluene)...
March 1, 2017: Journal of Colloid and Interface Science
Douglas H Fabini, Geneva Laurita, Jonathon S Bechtel, Constantinos C Stoumpos, Hayden A Evans, Athanassios G Kontos, Yannis S Raptis, Polycarpos Falaras, Anton Van der Ven, Mercouri G Kanatzidis, Ram Seshadri
Stable s(2) lone pair electrons on heavy main-group elements in their lower oxidation states drive a range of important phenomena, such as the emergence of polar ground states in some ferroic materials. Here we study the perovskite halide CsSnBr3 as an embodiment of the broader materials class. We show that lone pair stereochemical activity due to the Sn(2+) s(2) lone pair causes a crystallographically hidden, locally distorted state to appear upon warming, a phenomenon previously referred to as emphanisis...
September 14, 2016: Journal of the American Chemical Society
Thiago de Oliveira Mendes, Liliane Pereira Pinto, Laurita Dos Santos, Vamshi Krishna Tippavajhala, Claudio Alberto Téllez Soto, Airton Abrahão Martin
No abstract text is available yet for this article.
July 1, 2016: Journal of Biomedical Optics
Tilak Pasala, Mary Dettmer, Peter J Leo, Kenneth R Laurita, Elizabeth S Kaufman
INTRODUCTION: In experimental models, spatial dispersion of repolarization (DOR) due to discordant cellular alternans predisposes to ventricular fibrillation. To test the hypothesis that microvolt T-wave alternans (MTWA) in humans causes spatial DOR, we measured Tpeak-Tend interval (Tpe) and Tpe/QT ratio, electrocardiographic indices of spatial DOR. METHODS: Mean Tpe and Tpe/QT were compared in ischemic cardiomyopathy patients with positive and negative MTWA studies...
September 2016: Journal of Electrocardiology
Chiara Gualandi, Nora Bloise, Nicolò Mauro, Paolo Ferruti, Amedea Manfredi, Maurilio Sampaolesi, Anna Liguori, Romolo Laurita, Matteo Gherardi, Vittorio Colombo, Livia Visai, Maria Letizia Focarete, Elisabetta Ranucci
Electrospun poly-l-lactic acid (PLLA) nanofiber mats carrying surface amine groups, previously introduced by nitrogen atmospheric pressure nonequilibrium plasma, are embedded into aqueous solutions of oligomeric acrylamide-end capped AGMA1, a biocompatible polyamidoamine with arg-gly-asp (RGD)-reminiscent repeating units. The resultant mixture is finally cured giving PLLA-AGMA1 hydrogel composites that absorb large amounts of water and, in the swollen state, are translucent, soft, and pliable, yet as strong as the parent PLLA mat...
June 10, 2016: Macromolecular Bioscience
Prasongchai Sattayaprasert, Drew M Nassal, Xiaoping Wan, Isabelle Deschenes, Kenneth R Laurita
BACKGROUND: The paracrine action of non-cardiac progenitor cells is robust, but not well understood. Mesenchymal stem cells (MSC) have been shown to enhance calcium (Ca(++)) cycling in myocytes. Therefore, we hypothesized that MSCs can suppress cardiac alternans, an important arrhythmia substrate, by paracrine action on Ca(++) cycling. METHODS AND RESULTS: Human cardiac myocyte monolayers derived from iPS cells (hCM) were cultured without or with human MSCs (hMSC) directly or plated on a transwell insert...
September 2016: Journal of Molecular and Cellular Cardiology
Fernanda Kokowicz Pilatti, Fernanda Ramlov, Eder Carlos Schmidt, Marianne Kreusch, Débora Tomazi Pereira, Christopher Costa, Eva Regina de Oliveira, Cláudia M Bauer, Miguel Rocha, Zenilda Laurita Bouzon, Marcelo Maraschin
Refined fuels have considerable share of pollution of marine ecosystems. Gasoline is one of the most consumed fuel worldwide, but its effects on marine benthic primary producers are poorly investigated. In this study, Ulva lactuca was chosen as a biological model due to its cosmopolitan nature and tolerance to high levels and wide range of xenobiotics and our goal was to evaluate the effects of gasoline on ultrastructure and metabolism of that seaweed. The experimental design consisted of in vitro exposure of U...
August 2016: Chemosphere
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