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Emre Bektik, Adrienne Dennis, Gary Pawlowski, Chen Zhou, Danielle Maleski, Satoru Takahashi, Kenneth R Laurita, Isabelle Deschênes, Ji-Dong Fu
Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds a great promise for regenerative medicine and has been studied in several major directions. However, cell-cycle regulation, a fundamental biological process, has not been investigated during iCM-reprogramming. Here, our time-lapse imaging on iCMs, reprogrammed by Gata4, Mef2c, and Tbx5 (GMT) monocistronic retroviruses, revealed that iCM-reprogramming was majorly initiated at late-G1- or S-phase and nearly half of GMT-reprogrammed iCMs divided soon after reprogramming...
May 4, 2018: International Journal of Molecular Sciences
Víctor Manuel Mendoza-Núñez, Taide Laurita Arista-Ugalde, Juana Rosado-Pérez, Mirna Ruiz-Ramos, Edelmiro Santiago-Osorio
Introduction: The antioxidant and anti-inflammatory effects of Tai chi (TC) exercise training in healthy older adults has been demonstrated. However, there are no studies on this effect in older adults with metabolic syndrome (MetS). Purpose: The aim of this study was to determine the effect of TC exercise on oxidative stress and inflammatory markers in older adults with MetS. Methods: A quasi-experimental study was carried out with a sample of 110 older sedentary volunteers with clinical diagnoses of MetS: (i) a control group, n = 50, of individuals who do not participate in physical exercise, of which 37 fulfilled the entire study protocol, and (ii) an experimental group, n = 60, of subjects enrolled in a TC exercise training program (eight-form easy), 5 days a week for 6 months, in sessions of 50 min, under the supervision of a qualified instructor, of which 48 fulfilled the entire study protocol...
2018: Clinical Interventions in Aging
Fernando Scherner, Eduardo Bastos, Ticiane Rover, Eliana de Medeiros Oliveira, Rafael Almeida, Ana Gabriela Itokazu, Zenilda Laurita Bouzon, Leonardo Rubi Rörig, Sonia Maria Barreto Pereira, Paulo Antunes Horta
Seaweeds living at their temperature limits of distribution are naturally exposed to physiological stressors, facing additional stress when exposed to coastal pollution. The physiological responses of seaweeds to environmental conditions combining natural and anthropogenic stressors provide important information on their vulnerability. We assessed the physiological effects and ultrastructural alterations of trace metals enrichment at concentrations observed in polluted regions within the temperature ranges of distribution of the endemic seaweed Halimeda jolyana, an important component of tropical southwestern Atlantic reefs...
February 14, 2018: Environmental Science and Pollution Research International
Ji-Dong Fu, Kenneth R Laurita
No abstract text is available yet for this article.
February 2018: Circulation. Arrhythmia and Electrophysiology
Vitor C Chaves, Laurita Boff, Márcia Vizzotto, Eunice Calvete, Flávio H Reginatto, Cláudia Mo Simões
BACKGROUND: Phytochemical profiles of two Brazilian native fruits - pitanga (red and purple) and araçá (yellow and red) - as well as strawberry cultivars Albion, Aromas and Camarosa, blackberry cultivar Tupy and blueberry cultivar Bluegen cultivated in Brazil were characterized for total phenolic content and total anthocyanin content by liquid chromatography coupled to a photodiode array and a quadrupole time-of-flight mass spectrometer. Radical scavenging, antiherpes and cytotoxic activities of these berry extracts were also evaluated...
February 11, 2018: Journal of the Science of Food and Agriculture
N J Laurita, Yi Luo, Rongwei Hu, Meixia Wu, S W Cheong, O Tchernyshyov, N P Armitage
The symmetric splitting of two spin-wave branches in an antiferromagnetic resonance (AFR) experiment has been an essential measurement of antiferromagnets for over half a century. In this work, circularly polarized time-domain THz spectroscopy experiments performed on the low symmetry multiferroic hexagonal HoMnO_{3} reveal an AFR of the Mn sublattice to split asymmetrically in an applied magnetic field, with an ≈50% difference in g factors between the high and low energy branches of this excitation. The temperature dependence of the g factors, including a drastic renormalization at the Ho spin ordering temperature, reveals this asymmetry to unambiguously stem from Ho-Mn interactions...
December 1, 2017: Physical Review Letters
Emily C Schueller, Geneva Laurita, Douglas H Fabini, Constantinos C Stoumpos, Mercouri G Kanatzidis, Ram Seshadri
The temperature-dependent structure evolution of the hybrid halide perovskite compounds, formamidinium tin iodide (FASnI3 , FA+ = CH[NH2 ]2 + ) and formamidinium lead bromide (FAPbBr3 ), has been monitored using high-resolution synchrotron X-ray powder diffraction between 300 and 100 K. The data are consistent with a transition from cubic Pm3m (No. 221) to tetragonal P4/mbm (No. 127) for both materials upon cooling; this occurs for FAPbBr3 between 275 and 250 K, and for FASnI3 between 250 and 225 K. Upon further cooling, between 150 and 125 K, both materials undergo a transition to an orthorhombic Pnma (No...
January 16, 2018: Inorganic Chemistry
Joseph S Piktel, Aurelia Cheng, Matthew McCauley, Zack Dale, Michelle Nassal, Danielle Maleski, Gary Pawlowski, Kenneth R Laurita, Lance D Wilson
BACKGROUND: We designed an innovative porcine model of ischemia-induced arrest to determine dynamic arrhythmia substrates during focal infarct, global ischemia from ventricular tachycardia or fibrillation (VT/VF) and then reperfusion to determine the effect of therapeutic hypothermia (TH) on dynamic arrhythmia substrates and resuscitation outcomes. METHODS AND RESULTS: Anesthetized adult pigs underwent thoracotomy and regional plunge electrode placement in the left ventricle...
November 17, 2017: Journal of the American Heart Association
Luis Felipe C S Carvalho, Franck Bonnier, Cláudio Tellez, Laurita Dos Santos, Kate O'Callaghan, Jeff O'Sullivan, Luis Eduardo S Soares, Stephen Flint, Airton A Martin, Fiona M Lyng, Hugh J Byrne
Raman spectroscopy can provide a molecular-level signature of the biochemical composition and structure of cells with submicrometer spatial resolution and could be useful to monitor changes in composition for early stage and non-invasive cancer diagnosis, both ex-vivo and in vivo. In particular, the fingerprint spectral region (400-1800cm-1 ) has been shown to be very promising for optical biopsy purposes. However, limitations for discrimination of dysplastic and inflammatory processes based on the fingerprint region have been demonstrated...
December 2017: Experimental and Molecular Pathology
Douglas H Fabini, Ting Ann Siaw, Constantinos C Stoumpos, Geneva Laurita, Daniel Olds, Katharine Page, Jerry G Hu, Mercouri G Kanatzidis, Songi Han, Ram Seshadri
The role of organic molecular cations in the high-performance perovskite photovoltaic absorbers, methylammonium lead iodide (MAPbI3 ) and formamidinium lead iodide (FAPbI3 ), has been an enigmatic subject of great interest. Beyond aiding in the ease of processing of thin films for photovoltaic devices, there have been suggestions that many of the remarkable properties of the halide perovskites can be attributed to the dipolar nature and the dynamic behavior of these cations. Here, we establish the dynamics of the molecular cations in FAPbI3 between 4 K and 340 K and the nature of their interaction with the surrounding inorganic cage using a combination of solid state nuclear magnetic resonance and dielectric spectroscopies, neutron scattering, calorimetry, and ab initio calculations...
November 22, 2017: Journal of the American Chemical Society
Jacob C Buchanan, Dylan B Fast, Benjamin E Hanken, Thomas J L Mustard, Geneva Laurita, Tsung-Han Chiang, Douglas A Keszler, Mas A Subramanian, John F Wager, Michelle R Dolgos, James R Rustad, Paul Ha-Yeon Cheong
The study of structural properties of amorphous structures is complicated by the lack of long-range order and necessitates the use of both cutting-edge computer modeling and experimental techniques. With regards to the computer modeling, many questions on convergence arise when trying to assess the accuracy of a simulated system. What cell size maximizes the accuracy while remaining computationally efficient? More importantly, does averaging multiple smaller cells adequately describe features found in bulk amorphous materials? How small is too small? The aims of this work are: (1) to report a newly developed set of pair potentials for InGaZnO4 and (2) to explore the effects of structural parameters such as simulation cell size and numbers on the structural convergence of amorphous InGaZnO4 ...
November 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Geneva Laurita, Douglas H Fabini, Constantinos C Stoumpos, Mercouri G Kanatzidis, Ram Seshadri
Hybrid halide perovskites combine ease of preparation and relatively abundant constituent elements with fascinating photophysical properties. Descriptions of the chemical and structural drivers of the remarkable properties have often focused on the potential role of the dynamic order/disorder of the molecular A-site cations. We reveal here a key aspect of the inorganic framework that potentially impacts the electronic, thermal, and dielectric properties. The temperature evolution of the X-ray pair distribution functions of hybrid perovskites ABX3 [A(+) = CH3NH3 (MA) or CH(NH2)2 (FA); B(2+) = Sn or Pb; X(-) = Br, or I] in their cubic phases above 300 K reveals temperature-activated displacement (off-centering) of the divalent group 14 cations from their nominal, centered sites...
August 1, 2017: Chemical Science
Eleonora Turrini, Romolo Laurita, Augusto Stancampiano, Elena Catanzaro, Cinzia Calcabrini, Francesca Maffei, Matteo Gherardi, Vittorio Colombo, Carmela Fimognari
Cold atmospheric plasma (CAP) has shown its antitumor activity in both in vitro and in vivo systems. However, the mechanisms at the basis of CAP-cell interaction are not yet completely understood. The aim of this study is to investigate CAP proapoptotic effect and identify some of the molecular mechanisms triggered by CAP in human T-lymphoblastoid leukemia cells. CAP treatment was performed by means of a wand electrode DBD source driven by nanosecond high-voltage pulses under different operating conditions...
2017: Oxidative Medicine and Cellular Longevity
Graziela Cleuza Vieira, Patrícia Mirella da Silva, Margherita Anna Barracco, Augusto Ferrari Hering, Marcos Caivano Pedroso de Albuquerque, Jaqueline da Rosa Coelho, Éder Carlos Schmidt, Zenilda Laurita Bouzon, Rafael Diego Rosa, Luciane Maria Perazzolo
Hemocyte populations of the pearl oyster Pteria hirundo were characterized at morphological, ultrastructural and functional levels. Three main hemocyte populations were identified: hyalinocytes, granulocytes and blast-like cells. Hyalinocytes were the most abundant population (88.2%) characterized by the presence of few or no granules in the cytoplasm and composed by two subpopulations, large and small hyalinocytes. Comparatively, granulocytes represented 2.2% of the hemocyte population and were characterized by the presence of numerous large electron-lucid granules in the cytoplasm...
September 18, 2017: Fish & Shellfish Immunology
Malinda L C Buffon, Geneva Laurita, Leo Lamontagne, Emily E Levin, Shahryar Mooraj, Demetrious L Lloyd, Natalie White, Tresa M Pollock, Ram Seshadri
Heusler compounds XY 2 Z with 24 valence electrons per formula unit are potential thermoelectric materials, given their thermal and chemical stability and their relatively earth-abundant constituent elements. We present results on the 24-electron compound TiFe2 Sn here. First principles calculations on this compound suggest semiconducting behavior. A relatively flat conduction band that could be associated with a high Seebeck coefficient upon electron doping is found. A series of compounds have been prepared and characterized using a combination of synchrotron x-ray and neutron diffraction studies to understand the effects of site order/disorder phenomena and n-type doping...
October 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Matthew T McPheeters, Yves T Wang, Andreas A Werdich, Michael W Jenkins, Kenneth R Laurita
Human cardiac myocytes derived from pluripotent stem cells (hCM) have invigorated interest in genetic disease mechanisms and cardiac safety testing; however, the technology to fully assess electrophysiological function in an assay that is amenable to high throughput screening has lagged. We describe a fully contactless system using optical pacing with an infrared (IR) laser and multi-site high fidelity fluorescence imaging to assess multiple electrophysiological parameters from hCM monolayers in a standard 96-well plate...
2017: PloS One
Talitha Caldas Dos Santos, Nicoletta Rescignano, Laurita Boff, Flávio Henrique Reginatto, Cláudia Maria Oliveira Simões, Angela Machado de Campos, Carmen Ugarte Mijangos
Oral bioavailability of C-glycosyl flavonoid enriched fraction of Cecropia glaziovii (EFF-Cg) is limited due to its chemical complexity. The purpose of this study is the prospective evaluation of chitosan buccal films impregnated with EFF-Cg-loaded nanospheres as a drug delivery system for labial herpes treatment or for buccal administration. EFF-Cg-loaded PLGA nanospheres were prepared by double emulsion solvent evaporation technique. Nanoparticles were embedded into buccoadhesive chitosan films in different concentrations in order to obtain nanocomposite films...
October 1, 2017: Carbohydrate Polymers
Yu Sun, Valeriy Timofeyev, Adrienne Dennis, Emre Bektik, Xiaoping Wan, Kenneth R Laurita, Isabelle Deschênes, Ronald A Li, Ji-Dong Fu
The inward rectifier potassium current (IK1 ) is generally thought to suppress cardiac automaticity by hyperpolarizing membrane potential (MP). We recently observed that IK1 could promote the spontaneously-firing automaticity induced by upregulation of pacemaker funny current (If ) in adult ventricular cardiomyocytes (CMs). However, the intriguing ability of IK1 to activate If and thereby promote automaticity has not been explored. In this study, we combined mathematical and experimental assays and found that only IK1 and If , at a proper-ratio of densities, were sufficient to generate rhythmic MP-oscillations even in unexcitable cells (i...
October 2017: Stem Cell Reviews
Gail M Jensen, Laurita M Hack, Terrence Nordstrom, Janet Gwyer, Elizabeth Mostrom
This perspective shares recommendations that draw from (1) the National Study of Excellence and Innovation in Physical Therapist Education research findings and a conceptual model of excellence in physical therapist education, (2) the Carnegie Foundation's Preparation for the Professions Program (PPP), and (3) research in the learning sciences. The 30 recommendations are linked to the dimensions described in the conceptual model for excellence in physical therapist education: Culture of Excellence, Praxis of Learning, and Organizational Structures and Resources...
September 1, 2017: Physical Therapy
Gail M Jensen, Terrence Nordstrom, Elizabeth Mostrom, Laurita M Hack, Janet Gwyer
Background: The Carnegie Foundation for the Advancement of Teaching commissioned the Preparation for the Professions Program, a qualitative study of professional education in 5 professions: medicine, nursing, law, engineering, and clergy. These studies identified curricular structures, instructional practices, assessment approaches, and environmental characteristics that support the preparation of professionals and led to educational reforms. The physical therapy profession has not had any in-depth, national investigation of physical therapist education since the Catherine Worthingham studies conducted more than 50 years ago...
September 1, 2017: Physical Therapy
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