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https://www.readbyqxmd.com/read/29150491/hypothermia-modulates-arrhythmia-substrates-during-different-phases-of-resuscitation-from-ischemic-cardiac-arrest
#1
Joseph S Piktel, Aurelia Cheng, Matthew McCauley, Zack Dale, Michelle Nassal, Danielle Maleski, Gary Pawlowski, Kenneth R Laurita, Lance D Wilson
BACKGROUND: We designed an innovative porcine model of ischemia-induced arrest to determine dynamic arrhythmia substrates during focal infarct, global ischemia from ventricular tachycardia or fibrillation (VT/VF) and then reperfusion to determine the effect of therapeutic hypothermia (TH) on dynamic arrhythmia substrates and resuscitation outcomes. METHODS AND RESULTS: Anesthetized adult pigs underwent thoracotomy and regional plunge electrode placement in the left ventricle...
November 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29126766/raman-spectroscopic-analysis-of-oral-cells-in-the-high-wavenumber-region
#2
Luis Felipe C S Carvalho, Franck Bonnier, Cláudio Tellez, Laurita Dos Santos, Kate O'Callaghan, Jeff O'Sullivan, Luis Eduardo S Soares, Stephen Flint, Airton A Martin, Fiona M Lyng, Hugh J Byrne
Raman spectroscopy can provide a molecular-level signature of the biochemical composition and structure of cells with submicrometer spatial resolution and could be useful to monitor changes in composition for early stage and non-invasive cancer diagnosis, both ex-vivo and in vivo. In particular, the fingerprint spectral region (400-1800cm(-1)) has been shown to be very promising for optical biopsy purposes. However, limitations for discrimination of dysplastic and inflammatory processes based on the fingerprint region have been demonstrated...
November 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29094934/universal-dynamics-of-molecular-reorientation-in-hybrid-lead-iodide-perovskites
#3
Douglas H Fabini, Ting Ann Siaw, Constantinos C Stoumpos, Geneva Laurita, Daniel Olds, Katharine Page, Jerry G Hu, Mercouri G Kanatzidis, Songi Han, Ram Seshadri
The role of organic molecular cations in the high-performance perovskite photovoltaic absorbers, methylammonium lead iodide (MAPbI3) and formamidinium lead iodide (FAPbI3), has been an enigmatic subject of great interest. Beyond aiding in the ease of processing of thin films for photovoltaic devices, there have been suggestions that many of the remarkable properties of the halide perovskites can be attributed to the dipolar nature and the dynamic behavior of these cations. Here, we establish the dynamics of the molecular cations in FAPbI3 between 4 K and 340 K and the nature of their interaction with the surrounding inorganic cage using a combination of solid state nuclear magnetic resonance and dielectric spectroscopies, neutron scattering, calorimetry, and ab initio calculations...
November 2, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29068444/structural-convergence-properties-of-amorphous-ingazno4-from-simulated-liquid-quench-methods
#4
Jacob C Buchanan, Dylan B Fast, Benjamin E Hanken, Thomas J L Mustard, Geneva Laurita, Tsung-Han Chiang, Douglas A Keszler, Mas A Subramanian, John F Wager, Michelle R Dolgos, James R Rustad, Paul Ha-Yeon Cheong
The study of structural properties of amorphous structures is complicated by the lack of long-range order and necessitates the use of both cutting-edge computer modeling and experimental techniques. With regards to the computer modeling, many questions on convergence arise when trying to assess the accuracy of a simulated system. What cell size maximizes the accuracy while remaining computationally efficient? More importantly, does averaging multiple smaller cells adequately describe features found in bulk amorphous materials? How small is too small? The aims of this work are: (1) to report a newly developed set of pair potentials for InGaZnO4 and (2) to explore the effects of structural parameters such as simulation cell size and numbers on the structural convergence of amorphous InGaZnO4...
November 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28989600/chemical-tuning-of-dynamic-cation-off-centering-in-the-cubic-phases-of-hybrid-tin-and-lead-halide-perovskites
#5
Geneva Laurita, Douglas H Fabini, Constantinos C Stoumpos, Mercouri G Kanatzidis, Ram Seshadri
Hybrid halide perovskites combine ease of preparation and relatively abundant constituent elements with fascinating photophysical properties. Descriptions of the chemical and structural drivers of the remarkable properties have often focused on the potential role of the dynamic order/disorder of the molecular A-site cations. We reveal here a key aspect of the inorganic framework that potentially impacts the electronic, thermal, and dielectric properties. The temperature evolution of the X-ray pair distribution functions of hybrid perovskites ABX3 [A(+) = CH3NH3 (MA) or CH(NH2)2 (FA); B(2+) = Sn or Pb; X(-) = Br, or I] in their cubic phases above 300 K reveals temperature-activated displacement (off-centering) of the divalent group 14 cations from their nominal, centered sites...
August 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28947928/cold-atmospheric-plasma-induces-apoptosis-and-oxidative-stress-pathway-regulation-in-t-lymphoblastoid-leukemia-cells
#6
Eleonora Turrini, Romolo Laurita, Augusto Stancampiano, Elena Catanzaro, Cinzia Calcabrini, Francesca Maffei, Matteo Gherardi, Vittorio Colombo, Carmela Fimognari
Cold atmospheric plasma (CAP) has shown its antitumor activity in both in vitro and in vivo systems. However, the mechanisms at the basis of CAP-cell interaction are not yet completely understood. The aim of this study is to investigate CAP proapoptotic effect and identify some of the molecular mechanisms triggered by CAP in human T-lymphoblastoid leukemia cells. CAP treatment was performed by means of a wand electrode DBD source driven by nanosecond high-voltage pulses under different operating conditions...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28923525/morphological-and-functional-characterization-of-the-hemocytes-from-the-pearl-oyster-pteria-hirundo-and-their-immune-responses-against-vibrio-infections
#7
Graziela Cleuza Vieira, Patrícia Mirella da Silva, Margherita Anna Barracco, Augusto Ferrari Hering, Marcos Caivano Pedroso de Albuquerque, Jaqueline da Rosa Coelho, Éder Carlos Schmidt, Zenilda Laurita Bouzon, Rafael Diego Rosa, Luciane Maria Perazzolo
Hemocyte populations of the pearl oyster Pteria hirundo were characterized at morphological, ultrastructural and functional levels. Three main hemocyte populations were identified: hyalinocytes, granulocytes and blast-like cells. Hyalinocytes were the most abundant population (88.2%) characterized by the presence of few or no granules in the cytoplasm and composed by two subpopulations, large and small hyalinocytes. Comparatively, granulocytes represented 2.2% of the hemocyte population and were characterized by the presence of numerous large electron-lucid granules in the cytoplasm...
September 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28869750/thermoelectric-performance-and-the-role-of-anti-site-disorder-in-the-24-electron-heusler-tife2sn
#8
Malinda L C Buffon, Geneva Laurita, Leo Lamontagne, Emily E Levin, Shahryar Mooraj, Demetrious L Lloyd, Natalie White, Tresa M Pollock, Ram Seshadri
Heusler compounds XY 2 Z with 24 valence electrons per formula unit are potential thermoelectric materials, given their thermal and chemical stability and their relatively earth-abundant constituent elements. We present results on the 24-electron compound TiFe2Sn here. First principles calculations on this compound suggest semiconducting behavior. A relatively flat conduction band that could be associated with a high Seebeck coefficient upon electron doping is found. A series of compounds have been prepared and characterized using a combination of synchrotron x-ray and neutron diffraction studies to understand the effects of site order/disorder phenomena and n-type doping...
October 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28837652/an-infrared-optical-pacing-system-for-screening-cardiac-electrophysiology-in-human-cardiomyocytes
#9
Matthew T McPheeters, Yves T Wang, Andreas A Werdich, Michael W Jenkins, Kenneth R Laurita
Human cardiac myocytes derived from pluripotent stem cells (hCM) have invigorated interest in genetic disease mechanisms and cardiac safety testing; however, the technology to fully assess electrophysiological function in an assay that is amenable to high throughput screening has lagged. We describe a fully contactless system using optical pacing with an infrared (IR) laser and multi-site high fidelity fluorescence imaging to assess multiple electrophysiological parameters from hCM monolayers in a standard 96-well plate...
2017: PloS One
https://www.readbyqxmd.com/read/28732908/manufacture-and-characterization-of-chitosan-plga-nanoparticles-nanocomposite-buccal-films
#10
Talitha Caldas Dos Santos, Nicoletta Rescignano, Laurita Boff, Flávio Henrique Reginatto, Cláudia Maria Oliveira Simões, Angela Machado de Campos, Carmen Ugarte Mijangos
Oral bioavailability of C-glycosyl flavonoid enriched fraction of Cecropia glaziovii (EFF-Cg) is limited due to its chemical complexity. The purpose of this study is the prospective evaluation of chitosan buccal films impregnated with EFF-Cg-loaded nanospheres as a drug delivery system for labial herpes treatment or for buccal administration. EFF-Cg-loaded PLGA nanospheres were prepared by double emulsion solvent evaporation technique. Nanoparticles were embedded into buccoadhesive chitosan films in different concentrations in order to obtain nanocomposite films...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28623610/a-singular-role-of-ik1-promoting-the-development-of-cardiac-automaticity-during-cardiomyocyte-differentiation-by-ik1-induced-activation-of-pacemaker-current
#11
Yu Sun, Valeriy Timofeyev, Adrienne Dennis, Emre Bektik, Xiaoping Wan, Kenneth R Laurita, Isabelle Deschênes, Ronald A Li, Ji-Dong Fu
The inward rectifier potassium current (IK1) is generally thought to suppress cardiac automaticity by hyperpolarizing membrane potential (MP). We recently observed that IK1 could promote the spontaneously-firing automaticity induced by upregulation of pacemaker funny current (If) in adult ventricular cardiomyocytes (CMs). However, the intriguing ability of IK1 to activate If and thereby promote automaticity has not been explored. In this study, we combined mathematical and experimental assays and found that only IK1 and If, at a proper-ratio of densities, were sufficient to generate rhythmic MP-oscillations even in unexcitable cells (i...
October 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28586468/national-study-of-excellence-and-innovation-in-physical-therapist-education-part-2-a-call-to-reform
#12
Gail M Jensen, Laurita M Hack, Terrence Nordstrom, Janet Gwyer, Elizabeth Mostrom
This perspective shares recommendations that draw from (1) the National Study of Excellence and Innovation in Physical Therapist Education research findings and a conceptual model of excellence in physical therapist education, (2) the Carnegie Foundation's Preparation for the Professions Program (PPP), and (3) research in the learning sciences. The 30 recommendations are linked to the dimensions described in the conceptual model for excellence in physical therapist education: Culture of Excellence, Praxis of Learning, and Organizational Structures and Resources...
September 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28586430/national-study-of-excellence-and-innovation-in-physical-therapist-education-part-1-design-method-and-results
#13
Gail M Jensen, Terrence Nordstrom, Elizabeth Mostrom, Laurita M Hack, Janet Gwyer
Background: The Carnegie Foundation for the Advancement of Teaching commissioned the Preparation for the Professions Program, a qualitative study of professional education in 5 professions: medicine, nursing, law, engineering, and clergy. These studies identified curricular structures, instructional practices, assessment approaches, and environmental characteristics that support the preparation of professionals and led to educational reforms. The physical therapy profession has not had any in-depth, national investigation of physical therapist education since the Catherine Worthingham studies conducted more than 50 years ago...
September 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28415409/in-vitro-antiherpes-effect-of-c-glycosyl-flavonoid-enriched-fraction-of-cecropia-glaziovii-encapsulated-in-plga-nanoparticles
#14
Talitha Caldas Dos Santos, Nicoletta Rescignano, Laurita Boff, Flávio Henrique Reginatto, Cláudia Maria Oliveira Simões, Angela Machado de Campos, Carmen Mijangos
In this work is reported a novel and promising approach for the preparation of C-glycosylflavonoid enriched fraction of Cecropia glaziovii (EFF-Cg) loaded PLGA nanoparticles (NP) with antiherpes properties. The purpose of this study was to evaluate and to compare the effect of two nonionic surfactants (poloxamer 188 (PLU) and polyvinyl alcohol (PVA)), and also an emulsion stabilized by solid particles of cellulose nanocrystal (CNC) in place of surfactants. The characterization of these nanoparticles was in terms of size, polydispersity index, zeta potential, morphology, thermogravimetric analysis (TGA), loading capacity and percent yield...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28407150/dissociable-patterns-of-brain-activity-for-mentalizing-about-known-others-a-role-for-attachment
#15
Anne C Laurita, Cindy Hazan, R Nathan Spreng
The human brain tracks dynamic changes within the social environment, forming and updating representations of individuals in our social milieu. This mechanism of social navigation builds an increasingly complex map of persons with whom we are familiar and form attachments to guide adaptive social behaviors. We examined the neural representation of known others along a continuum of attachment using fMRI. Heterosexual adults (N = 29, 16 females), in romantic relationships for more than 2 years, made trait judgments for a romantic partner, parent, close friend, familiar acquaintance and self-during scanning...
July 1, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28406617/the-role-of-structural-and-compositional-heterogeneities-in-the-insulator-to-metal-transition-in-hole-doped-apd3o4-a-ca-sr
#16
Leo K Lamontagne, Geneva Laurita, Michael Knight, Huma Yusuf, Jerry Hu, Ram Seshadri, Katharine Page
The cubic semiconducting compounds APd3O4 (A = Ca, Sr) can be hole-doped by Na substitution on the A site and driven toward more conducting states. This process has been followed here by a number of experimental techniques to understand the evolution of electronic properties. While an insulator-to-metal transition is observed in Ca1-xNaxPd3O4 for x ≥ 0.15, bulk metallic behavior is not observed for Sr1-xNaxPd3O4 up to x = 0.20. Given the very similar crystal and (calculated) electronic structures of the two materials, the distinct behavior is a matter of interest...
April 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28384221/kchip2-regulates-the-cardiac-ca2-transient-and-myocyte-contractility-by-targeting-ryanodine-receptor-activity
#17
Drew M Nassal, Xiaoping Wan, Haiyan Liu, Kenneth R Laurita, Isabelle Deschênes
Pathologic electrical remodeling and attenuated cardiac contractility are featured characteristics of heart failure. Coinciding with these remodeling events is a loss of the K+ channel interacting protein, KChIP2. While, KChIP2 enhances the expression and stability of the Kv4 family of potassium channels, leading to a more pronounced transient outward K+ current, Ito,f, the guinea pig myocardium is unique in that Kv4 expression is absent, while KChIP2 expression is preserved, suggesting alternative consequences to KChIP2 loss...
2017: PloS One
https://www.readbyqxmd.com/read/28263709/kchip2-is-a-core-transcriptional-regulator-of-cardiac-excitability
#18
Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S Moravec, Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes
Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in numerous cardiac pathologies. However, it remains unknown if KChIP2 loss is merely a symptom or involved in disease development. Using rat and human derived cardiomyocytes, we identify a previously unobserved transcriptional capacity for cardiac KChIP2 critical in maintaining electrical stability...
March 6, 2017: ELife
https://www.readbyqxmd.com/read/28165235/structural-evolution-and-atom-clustering-in-%C3%AE-sialon-%C3%AE-si6-zalzozn8-z
#19
Clayton Cozzan, Kent J Griffith, Geneva Laurita, Jerry G Hu, Clare P Grey, Ram Seshadri
SiAlON ceramics, solid solutions based on the Si3N4 structure, are important, lightweight structural materials with intrinsically high strength, high hardness, and high thermal and chemical stability. Described by the chemical formula β-Si6-zAlzOzN8-z, from a compositional viewpoint, these materials can be regarded as solid solutions between Si3N4 and Al3O3N. A key aspect of the structural evolution with increasing Al and O (z in the formula) is to understand how these elements are distributed on the β-Si3N4 framework...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28123587/analysis-of-molecular-markers-as-predictive-factors-of-lymph-node-involvement-in-breast-carcinoma
#20
Luciana Marques Paula, Luis Henrique Ferreira De Moraes, Abaeté Leite Do Canto, Laurita Dos Santos, Airton Abrahão Martin, Silvia Regina Rogatto, Renata De Azevedo Canevari
Nodal status is the most significant independent prognostic factor in breast cancer. Identification of molecular markers would allow stratification of patients who require surgical assessment of lymph nodes from the large numbers of patients for whom this surgical procedure is unnecessary, thus leading to a more accurate prognosis. However, up to now, the reported studies are preliminary and controversial, and although hundreds of markers have been assessed, few of them have been used in clinical practice for treatment or prognosis in breast cancer...
January 2017: Oncology Letters
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