keyword
https://read.qxmd.com/read/38521120/comprehensive-review-of-statin-intolerance-and-the-practical-application-of-bempedoic-acid
#1
REVIEW
Siva Naga S Yarrarapu, Amandeep Goyal, Vikramaditya Samala Venkata, Viraj Panchal, Barath Prashanth Sivasubramanian, Doantrang T Du, Roopesh Sai Jakulla, Hema Pamulapati, Mazhar A Afaq, Steven Owens, Tarun Dalia
Statin-intolerance (SI) has prevalence between 8.0 % and 10 %, and muscular complaints are the most common reason for discontinuation. Bempedoic acid (BA), an ATP citrate lyase inhibitor, decreases hepatic generation of cholesterol, upregulates low-density lipoprotein (LDL) receptor expression in the liver, and eventually clears circulating LDL-cholesterol from the blood. Multiple randomized clinical trials studying BA demonstrate a reduction in LDL levels by 17-28 % in SI. The CLEAR OUTCOME trial established significant cardiovascular benefits with BA...
March 21, 2024: Journal of Cardiology
https://read.qxmd.com/read/38409440/cardiovascular-risk-management-among-individuals-with-type-2-diabetes-and-severe-mental-illness-a-cohort-study
#2
JOURNAL ARTICLE
Jonne G Ter Braake, Kelly J Fleetwood, Rimke C Vos, Luke Blackbourn, Stuart J McGurnaghan, Sarah H Wild, Caroline A Jackson
AIMS/HYPOTHESIS: The aim of this study was to compare cardiovascular risk management among people with type 2 diabetes according to severe mental illness (SMI) status. METHODS: We used linked electronic data to perform a retrospective cohort study of adults diagnosed with type 2 diabetes in Scotland between 2004 and 2020, ascertaining their history of SMI from hospital admission records. We compared total cholesterol, systolic BP and HbA1c target level achievement 1 year after diabetes diagnosis, and receipt of a statin prescription at diagnosis and 1 year thereafter, by SMI status using logistic regression, adjusting for sociodemographic factors and clinical history...
February 26, 2024: Diabetologia
https://read.qxmd.com/read/38265512/risk-and-effect-modifiers-for-poor-glycemic-control-among-the-chinese-diabetic-adults-on-statin-therapy-the-kailuan-study
#3
JOURNAL ARTICLE
Zhaogui Wu, Shuohua Chen, Xixi Tao, Hangkuan Liu, Pengfei Sun, Arthur Mark Richards, Huay Cheem Tan, Ying Yu, Qing Yang, Shouling Wu, Xin Zhou
BACKGROUND: Limited studies have investigated the association between statin therapy and poor glycemic control, especially in the Chinese diabetic population. METHODS: Two prospective diabetes cohorts were drawn from the Kailuan Cohort. In Cohort 1, linear regression models were used to evaluate the association between statin therapy and glycated hemoglobin (HbA1c) level change. In Cohort 2, new user design and conditional logistic models were used to assess associations between statin initiation and poor glycemic control which was a composite outcome comprised of hypoglycemic agent escalation and new-onset hyperglycemia...
January 24, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38166049/real-world-evaluation-of-care-for-type-2-diabetes-in-malaysia-a-cross-sectional-analysis-of-the-treatment-adherence-to-guideline-evaluation-in-type-2-diabetes-target-t2d-study
#4
JOURNAL ARTICLE
Lee-Ling Lim, Zanariah Hussein, Nurain Md Noor, Anis S Abd Raof, Norlaila Mustafa, Mohamed B Long Bidin, Rohana Abdul Ghani, Syahrizan Samsuddin, Sy-Liang Yong, Siew-Hui Foo, Kavitha Raghuram, Payiarat Suwannasri, Wan Mohamad W B, Thiam-Kian Chiew, Siew-Pheng Chan
AIM: Given a lack of data on diabetes care performance in Malaysia, we conducted a cross-sectional study to understand the clinical characteristics, control of cardiometabolic risk factors, and patterns of use of guideline-directed medical therapy (GDMT) among patients with type 2 diabetes (T2D), who were managed at publicly-funded hospitals between December 2021 and June 2022. METHODS: Patients aged ≥18 years with T2D from eight publicly-funded hospitals in the Greater Kuala Lumpur region, who had ≥2 outpatient visits within the preceding year and irrespective of treatment regimen, were eligible...
2024: PloS One
https://read.qxmd.com/read/38061370/efficacy-and-safety-of-bempedoic-acid-among-patients-with-and-without-diabetes-prespecified-analysis-of-the-clear-outcomes-randomised-trial
#5
JOURNAL ARTICLE
Kausik K Ray, Stephen J Nicholls, Na Li, Michael J Louie, Danielle Brennan, A Michael Lincoff, Steven E Nissen
BACKGROUND: Statins reduce LDL cholesterol and cardiovascular events among those with or without diabetes but have been reported to increase new-onset diabetes. The CLEAR Outcomes trial demonstrated that bempedoic acid reduced the risk of major adverse cardiovascular events among statin-intolerant patients at high cardiovascular risk. In this prespecified analysis, our dual aims were to evaluate the cardiovascular benefits of bempedoic acid, an ATP-citrate lyase inhibitor, in individuals with diabetes, and to evaluate the risk of new-onset diabetes and HbA1c among those without diabetes in the CLEAR Outcomes trial...
December 4, 2023: Lancet Diabetes & Endocrinology
https://read.qxmd.com/read/38058709/eligibility-for-icosapent-ethyl-in-a-french-population-of-coronary-outpatients-with-type-2-diabetes
#6
JOURNAL ARTICLE
Pierre François Sabouret, Jean-Claude Dib, Fiona Ecarnot, Maciej Banach, Nicolas Lellouche
INTRODUCTION: We determined eligibility for icosapent ethyl (EPA) treatment in coronary artery disease (CAD). METHODS: Consecutive patients with type 2 diabetes and CAD were prospectively included from 03/2019 to 12/2020. RESULTS: 574 patients were included; mean age 71 years, 81% males, with a high prevalence of other risk factors (81% hypertension). Mean lipid-density lipoprotein cholesterol was 85 mg/dl, mean glycated hemoglobin HbA1c 7...
2023: Archives of Medical Science: AMS
https://read.qxmd.com/read/38053073/status-of-lipid-control-in-bangladeshi-subjects-with-type-2-diabetes-mellitus-on-lipid-lowering-drugs-a-multicenter-facility-based-cross-sectional-study
#7
MULTICENTER STUDY
Shahjada Selim, Muhammad Shah Alam, Samir Kumar Talukder, Md Lutful Kabir, Abu Jar Gaffar, Md Ahamedul Kabir, Nusrat Zarin, Shahin Ibn Rahman, Md Masud Un Nabi, Marufa Mustari, Md Firoj Hossain, Ahmed Ifrad Bin Raunak, Md Azizul Hoque, Md Rashedul Islam, Farhana Akter, Mohammad Abdul Hannan, Mohammad Saifuddin, Md Asaduzzaman, Mohammad Motiur Rahman, Afsar Ahammed, Md Abdur Rafi, Mohammad Jahid Hasan, A B M Kamrul-Hasan
BACKGROUND: Achievement of lipid targets is crucial in patients with type 2 diabetes mellitus (T2DM) to mitigate the risk of cardiovascular diseases (CVD). Data on lipid-control status among patients with T2DM in Bangladesh are scarce. This study was conducted to determine the lipid-control status among patients with T2DM who were on lipid-lowering drugs in the country. METHODS: This cross-sectional study was conducted in the diabetes outpatient departments of several tertiary hospitals in Bangladesh from January 2022 to December 2022...
December 5, 2023: BMC Endocrine Disorders
https://read.qxmd.com/read/38001968/analysis-of-methylglyoxal-concentration-in-a-group-of-patients-with-newly-diagnosed-prediabetes
#8
JOURNAL ARTICLE
Edyta Sutkowska, Izabela Fecka, Dominik Marciniak, Katarzyna Bednarska, Magdalena Sutkowska, Katarzyna Hap
BACKGROUND: The abnormal serum concentration of methylglyoxal (MGO) has been presented as an indicator of chronic complications in diabetes (DM). Because such complications are also found in pre-DM, we decided to assess the concentration of this compound in individuals with pre-DM, without cardio-vascular diseases. METHODS: Frozen samples from individuals newly diagnosed with pre-DM (N = 31) and healthy subjects (N = 11) were prepared and MGO concentration was determined using UHPLC-ESI-QqTOF-MS...
November 3, 2023: Biomedicines
https://read.qxmd.com/read/37949074/-laboratory-diagnostics-of-lipid-metabolism-disorders
#9
JOURNAL ARTICLE
Winfried März, Hubert Scharnagl, Marcus Kleber, Günther Silbernagel, Matthias Nauck, Dirk Müller-Wieland, Arnold von Eckardstein
Clinically, disorders of lipid metabolism often remain without symptoms. Typical skin lesions, however, can be indicative. Secondary hyperlipoproteinemias (HLP) are more common than primary hyperlipoproteinemias; they can (partially) be improved by treating the underlying disease. Basic diagnostics consist of the determination of cholesterol, triglycerides, LDL cholesterol and HDL cholesterol. To exclude secondary HLP, glucose, HbA1C , TSH, transaminases, creatinine, urea, protein and protein in the urine are useful...
November 2023: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/37947085/development-and-validation-of-the-american-heart-association-s-prevent-equations
#10
JOURNAL ARTICLE
Sadiya S Khan, Kunihiro Matsushita, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Michael J Blaha, April P Carson, Alexander R Chang, Elizabeth Ciemins, Alan S Go, Orlando M Gutierrez, Shih-Jen Hwang, Simerjot K Jassal, Csaba P Kovesdy, Donald M Lloyd-Jones, Michael G Shlipak, Latha P Palaniappan, Laurence Sperling, Salim S Virani, Katherine Tuttle, Ian J Neeland, Sheryl L Chow, Janani Rangaswami, Michael J Pencina, Chiadi E Ndumele, Josef Coresh
BACKGROUND: Multivariable equations are recommended by primary prevention guidelines to assess absolute risk of cardiovascular disease (CVD). However, current equations have several limitations. Therefore, we developed and validated the American Heart Association Predicting Risk of CVD EVENTs (PREVENT) equations among US adults 30 to 79 years of age without known CVD. METHODS: The derivation sample included individual-level participant data from 25 data sets (N=3 281 919) between 1992 and 2017...
February 6, 2024: Circulation
https://read.qxmd.com/read/37892811/effect-of-lipids-on-diabetic-retinopathy-in-a-large-cohort-of-diabetic-patients-after-10-years-of-follow-up
#11
JOURNAL ARTICLE
Pedro Romero-Aroca, Raquel Verges, Jordi Pascual-Fontanilles, Aida Valls, Josep Franch, Joan Barrot, Xavier Mundet, Alex La Torre, Antonio Moreno, Ramon Sagarra, Josep Basora, Eugeni Garcia-Curto, Marc Baget-Bernaldiz
(1) Background: Diabetic retinopathy (DR) remains the leading cause of low vision and blindness in young adults of working age. Although the most important risk factors-such as the duration of diabetes mellitus (DM) and glycemic control measured by HbA1c-are known, the effects of lipids are not as clear. The aim of the present study is to analyze the effects of lipids on the development of DR. (2) Methods: This is a retrospective study of a population of 175,645 DM2 patients, during the period 2010 to 2020, in which the effects of different lipid factors are studied...
October 22, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37833402/baseline-treatments-and-metabolic-control-of-288-913-type-2-diabetes-patients-in-a-10-year-retrospective-cohort-in-malaysia
#12
JOURNAL ARTICLE
Kim Sui Wan, Feisul Mustapha, Arunah Chandran, Shubash Shander Ganapathy, Nurhaliza Zakariah, Sivarajan Ramasamy, Gunenthira Rao Subbarao, Muhammad Fadhli Mohd Yusoff
Diabetes is one of the quickest-growing global health emergencies of the twenty-first century, and data-driven care can improve the quality of diabetes management. We aimed to describe the formation of a 10-year retrospective open cohort of type 2 diabetes patients in Malaysia. We also described the baseline treatment profiles and HbA1c, blood pressure, and lipid control to assess the quality of diabetes care. We used 10 years of cross-sectional audit datasets from the National Diabetes Registry and merged 288,913 patients with the same identifying information into a 10-year open cohort dataset...
October 13, 2023: Scientific Reports
https://read.qxmd.com/read/37828071/impact-of-diabetes-mellitus-severity-treatment-regimen-and-glycaemic-control-on-atrial-fibrillation-prevalence-in-the-polish-population-aged%C3%A2-%C3%A2-%C3%A2-65
#13
JOURNAL ARTICLE
Jakub Gumprecht, Gregory Y H Lip, Adam Sokal, Beata Średniawa, Jakub Stokwiszewski, Tomasz Zdrojewski, Marcin Rutkowski, Tomasz Grodzicki, Jarosław Kaźmierczak, Grzegorz Opolski, Zbigniew Kalarus
Diabetes mellitus (DM) is a well-known risk factor for atrial fibrillation (AF), but the mechanism(s) by which DM affects AF prevalence remains unclear. This study aims to evaluate the impact of diabetes mellitus severity (expressed as its known duration), antihyperglycemic treatment regimen and glycaemic control on AF prevalence. From the representative sample of 3014 participants (mean age 77.5, 49.1% female) from the cross-sectional NOMED-AF study, 881 participants (mean age 77.6 ± 0.25, 46...
October 12, 2023: Scientific Reports
https://read.qxmd.com/read/37763042/effect-of-high-intensity-rosuvastatin-vs-combination-of-low-intensity-rosuvastatin-and-ezetimibe-on-hba1c-levels-in-patients-without-diabetes-a-randomized-ideal-trial
#14
JOURNAL ARTICLE
Jeongcheon Choe, Sun-Hack Lee, Jinhee Ahn, Hyewon Lee, Jun-Hyok Oh, Junghyun Choi, Hancheol Lee, Kwangsoo Cha, Jinsup Park
There is a dearth of studies investigating whether the combination of low-intensity statins with ezetimibe can reduce the risk of diabetes in patients requiring statin therapy. Therefore, we aimed to evaluate the effects of combination therapy on the prevention of glycated hemoglobin (HbA1c) elevation in patients without diabetes. Sixty-eight patients were randomly assigned in a 1:1 ratio to receive a combination of low-intensity rosuvastatin (5 mg/day) and ezetimibe (10 mg/day) or high-intensity rosuvastatin (20 mg/day)...
September 21, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37692611/microalbuminuria-as-the-tip-of-iceberg-in-type-2-diabetes-mellitus-prevalence-risk-factors-and-associated-diabetic-complications
#15
JOURNAL ARTICLE
Sohaib Asghar, Shoaib Asghar, Tayyab Mahmood, Syed Muhammad Hassan Bukhari, Muhammad Habib Mumtaz, Ali Rasheed
Background Microalbuminuria (MA) is an important clinical marker for the early detection of kidney damage in patients with type 2 diabetes (T2DM). Urine albumin-to-creatinine ratio (ACR), also known as urine microalbumin, is a sign of diabetic nephropathy (DN), which is a prevalent complication of diabetes and can result in end-stage renal disease (ESRD) if not managed. The prevalence of MA in T2DM has been steadily increasing worldwide, making it a significant public health concern. The goal of this study was to estimate the prevalence of MA and its relationship to hypertension and other diabetic complications among people with T2DM...
August 2023: Curēus
https://read.qxmd.com/read/37671124/sex-specific-risks-for-cardiovascular-disease-across-the-glycaemic-spectrum-a-population-based-cohort-study-using-the-uk-biobank
#16
JOURNAL ARTICLE
Christopher T Rentsch, Victoria Garfield, Rohini Mathur, Sophie V Eastwood, Liam Smeeth, Nish Chaturvedi, Krishnan Bhaskaran
BACKGROUND: We sought to examine sex-specific risks for incident cardiovascular disease (CVD) across the full glycaemic spectrum. METHODS: Using data from UK Biobank, we categorised participants' glycated haemoglobin (HbA1c) at baseline as low-normal (<35 mmol/mol), normal (35-41 mmol/mol), pre-diabetes (42-47 mmol/mol), undiagnosed diabetes (≥48 mmol/mol), or diagnosed diabetes. Our outcomes were coronary artery disease (CAD), atrial fibrillation, deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, heart failure, and a composite outcome of any CVD...
September 2023: The Lancet regional health. Europe
https://read.qxmd.com/read/37644964/impact-of-covid-19-lockdown-on-glycemic-weight-blood-pressure-control-and-medication-adherence-in-patients-with-type-2-diabetes
#17
JOURNAL ARTICLE
Ruth Sim, Chun Wie Chong, Navin Kumar Loganadan, Zanariah Hussein, Noor Lita Adam, Shaun Wen Huey Lee
Medication adherence profoundly affects blood glucose management in patients with type 2 diabetes. Measures to contain the COVID-19 pandemic have affected disease management and medication adherence, owing to limited access to healthcare facilities. This study aimed to examine the impact of the COVID-19 lockdown on adherence to glucose-lowering and lipid-lowering therapies (statins), and glycemic, weight, and systolic blood pressure control measures. A retrospective chart review was conducted one year pre- and post- March 18, 2020, for patients receiving glucose-lowering medications and lipid-lowering therapies (statins) in two major public hospitals in Malaysia...
2023: Patient Preference and Adherence
https://read.qxmd.com/read/37598214/evaluation-of-the-diabetes-care-cascade-and-compliance-with-who-global-coverage-targets-in-iran-based-on-steps-survey-2021
#18
JOURNAL ARTICLE
Sina Azadnajafabad, Naser Ahmadi, Negar Rezaei, Mohammad-Mahdi Rashidi, Sahar Saeedi Moghaddam, Esmaeil Mohammadi, Mohsen Abbasi-Kangevari, Mohammadreza Naderian, Erfan Ghasemi, Yosef Farzi, Ameneh Kazemi, Arezou Dilmaghani-Marand, Moein Yoosefi, Shahabeddin Rezaei, Maryam Nasserinejad, Nima Fattahi, Nazila Rezaei, Rosa Haghshenas, Elmira Foroutan Mehr, Sogol Koolaji, Farideh Razi, Shirin Djalalinia, Bagher Larijani, Farshad Farzadfar
This study aimed to investigate the diabetes mellitus (DM) and prediabetes epidemiology, care cascade, and compliance with global coverage targets. We recruited the results of the nationally representative Iran STEPS Survey 2021. Diabetes and prediabetes were two main outcomes. Diabetes awareness, treatment coverage, and glycemic control were calculated for all population with diabetes to investigate the care cascade. Four global coverage targets for diabetes developed by the World Health Organization were adopted to assess the DM diagnosis and control status...
August 19, 2023: Scientific Reports
https://read.qxmd.com/read/37581619/atorvastatin-lowers-68-ga-dotatate-uptake-in-coronary-arteries-bone-marrow-and-spleen-in-individuals-with-type-2-diabetes
#19
JOURNAL ARTICLE
Reindert F Oostveen, Yannick Kaiser, Mia R Ståhle, Nick S Nurmohamed, Evangelos Tzolos, Marc R Dweck, Jeffrey Kroon, Andrew J Murphy, Damini Dey, Piotr J Slomka, Hein J Verberne, Erik S G Stroes, Nordin M J Hanssen
AIMS/HYPOTHESIS: Inflammation is a core component of residual cardiovascular risk in type 2 diabetes. With new anti-inflammatory therapeutics entering the field, accurate markers to evaluate their effectiveness in reducing cardiovascular disease are paramount. Gallium-68-labelled DOTATATE (68 Ga-DOTATATE) has recently been proposed as a more specific marker of arterial wall inflammation than 18 F-fluorodeoxyglucose (18 F-FDG). This study set out to investigate whether 68 Ga-DOTATATE uptake is amenable to therapeutic intervention in individuals with type 2 diabetes...
August 15, 2023: Diabetologia
https://read.qxmd.com/read/37528178/risk-of-first-time-major-cardiovascular-event-among-individuals-with-newly-diagnosed-type-2-diabetes-data-from-danish-registers
#20
JOURNAL ARTICLE
Alexander C Falkentoft, Thomas Alexander Gerds, Bochra Zareini, Filip K Knop, Lars Køber, Christian Torp-Pedersen, Morten Schou, Niels E Bruun, Anne-Christine Ruwald
AIMS/HYPOTHESIS: We aimed to examine whether individuals with initial omission of glucose-lowering drug treatment (GLDT), including those achieving initial remission of type 2 diabetes, may experience a higher risk of major adverse cardiovascular events (MACE) compared with well-controlled individuals on GLDT after a new type 2 diabetes diagnosis in real-world clinical practice. Furthermore, we examined whether a higher risk could be related to lower initiation of statins and renin-angiotensin system inhibitors (RASi)...
August 2, 2023: Diabetologia
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