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https://www.readbyqxmd.com/read/28747411/stroke-of-the-inferiomedial-temporal-lobe-causing-word-agnosia
#1
Hardi Hassan, Huq Ehsanula, Mahendra Pattanshetti
A 69-year-old man presented with sudden loss of ability to recognise written words and remember the meaning of words and names. He could not name the town he lived in nor name his children. It was difficult for him to remember the meaning of concrete and abstract nouns. His speech fluency and understanding of casual talks were normal. He remembered that he had a conversation with his family that morning, but not the exact content. He was referred to the transient ischaemic attack clinic by his general practitioner as he scored low on the abbreviated mental test score...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28742971/evidence-for-quinone-redox-chemistry-mediating-daytime-and-nighttime-no2-to-hono-conversion-on-soil-surfaces
#2
Nicole K Scharko, Erin T Martin, Yaroslav B Losovyj, Dennis G Peters, Jonathan D Raff
Humic acid (HA) is thought to promote NO2 conversion to nitrous acid (HONO) on soil surfaces during the day. However, it has proven difficult to identify the reactive sites in natural HA substrates. The mechanism of NO2 reduction on soil surrogates comprised of HA and clay minerals was studied by use of a coated-wall flow reactor coupled to cavity-enhanced spectroscopy. Conversion of NO2 to HONO in the dark was found to be significant and correlated to the abundance of C‒O moieties in HA determined from X-ray photoelectron spectra of the C1s region...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28736417/choosing-flourishing-toward-a-more-binocular-way-of-thinking-about-disability
#3
Erik Parens
There is a long-standing debate between people who can seem to be arguing "for" and "against" disability. Those arguing for have often been disability scholars and those arguing against have often been utilitarian philosophers. At least since the mid-2000s, some on both sides have sought to move beyond that debate, but that has proved difficult. Here I seek two small steps forward. One step is critical, and is aimed at we who line up "for" disability. Specifically, I suggest that the phrase "choosing disability" is misleading in at least two ways...
2017: Kennedy Institute of Ethics Journal
https://www.readbyqxmd.com/read/28735564/synergistic-effect-of-co-digestion-to-enhance-anaerobic-degradation-of-catering-waste-and-orange-peel-for-biogas-production
#4
Muzammil Anjum, Azeem Khalid, Samia Qadeer, Rashid Miandad
Catering waste and orange peel were co-digested using an anaerobic digestion process. Orange peel is difficult to degrade anaerobically due to the presence of antimicrobial agents such as limonene. The present study aimed to examine the feasibility of anaerobic co-digestion of catering waste with orange peel to provide the optimum nutrient balance with reduced inhibitory effects of orange peel. Batch experiments were conducted using catering waste as a potential substrate mixed in varying ratios (20-50%) with orange peel...
July 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28735145/metabolic-gene-targeted-monitoring-of-non-starter-lactic-acid-bacteria-during-cheese-ripening
#5
Alessia Levante, Francesca De Filippis, Antonietta La Storia, Monica Gatti, Erasmo Neviani, Danilo Ercolini, Camilla Lazzi
Long ripened cheeses, such as Grana Padano (GP), a Protected Designation of Origin (PDO) Italian cheese, harbor a viable microbiota mainly composed of non-starter lactic acid bacteria (NSLAB), which contribute to the final characteristics of cheese. The NSLAB species Lactobacillus rhamnosus, Lb. casei and Lb. paracasei are frequently found in GP, and form a closely related taxonomic group (Lb. casei group), making it difficult to distinguish the three species through 16S rRNA sequencing. SpxB, a metabolic gene coding for pyruvate oxidase in Lb...
July 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28731954/laparoscopic-pancreaticoduodenectomy-a-single-team-preliminary-experience
#6
Xiaohui Duan, Bo Jiang, Lixue Zhou, Jianhui Yang, Bingzhang Tian, Huiming Wen, Xianhai Mao
OBJECTIVE: The present study aimed to describe the authors' experience and the perioperative outcome for laparoscopic pancreaticoduodenectomy (LPD). MATERIALS AND METHODS: Perioperative clinical data of 57 consecutive pancreaticoduodenectomy (PD) procedures performed from January 2014 to May 2016 in the Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital were retrospectively analyzed. RESULTS: The median of operative time was 315 minutes (range, 220 to 575 min) and the median of intraoperative estimated blood loss was 200 mL (range, 100 to 550 mL)...
July 20, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28727521/ethical-guidance-for-disaster-response-specifically-around-crisis-standards-of-care-a-systematic-review
#7
Jonathon P Leider, Debra DeBruin, Nicole Reynolds, Angelica Koch, Judy Seaberg
BACKGROUND: Terrorism, disease outbreaks, and other natural disasters and mass casualty events have pushed health care and public health systems to identify and refine emergency preparedness protocols for disaster response. Ethical guidance, alongside legal and medical frameworks, are increasingly common components of disaster response plans. OBJECTIVES: To systematically review the prevalence and content of ethical guidance offered for disaster response, specifically around crisis standards of care (CSCs)...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28725453/development-of-an-implementation-intention-based-intervention-to-change-children-s-and-parent-carers-behaviour
#8
Karen Davies, Christopher J Armitage, Yin-Ling Lin, James Munro, Tanya Walsh, Peter Callery
BACKGROUND: Implementation intentions enable individuals to translate good intentions into action. Parents and children can find maintaining oral health difficult, as evidenced by the presence of tooth decay. This is a common condition in children in spite of being preventable through the use of regular tooth brushing, fluoride protection and avoiding sugar intake. Even when parents and children are positive about looking after the teeth, they can face challenges in maintaining consistent habits...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28723302/why-use-group-visits-for-opioid-use-disorder-treatment-in-primary-care-a-patient-centered-qualitative-study
#9
Randi Sokol, Chiara Albanese, Deviney Chaponis, Jessica Early, George Maxted, Diana Morrill, Grace Poirier, Fran Puopolo, Zev Schuman-Olivier
BACKGROUND: Primary care providers are well positioned to respond to the opioid crisis by providing buprenorphine/naloxone (B/N) through shared medical appointments (SMA). While quantitative research has been previously conducted on SMAs with B/N, we conducted a qualitative assessment from the patients' point of view, considering whether and how group visits provide value for patients. METHODS: Twenty-five participants with opioid use disorder (OUD) who were enrolled in a weekly B/N group visit at a family medicine clinic participated in either of two one-hour-long focus groups, which were conducted as actual group visits...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28723098/a-new-area-in-main-group-chemistry-zerovalent-monoatomic-silicon-compounds-and-their-analogues
#10
Shenglai Yao, Yun Xiong, Matthias Driess
Monoatomic zerovalent main-group element complexes emerged very recently and attracted increasing attention of both theoretical and experimental chemists. In particular, zerovalent silicon complexes and their congeners (metallylones) stabilized by neutral Lewis donors are of significant importance not only because of their intriguing electronic structure but also because they can serve as useful building blocks for novel chemical species. Featuring four valence electrons as two lone pairs at the central atoms, such complexes may form donor-acceptor adducts with Lewis acids...
July 19, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28712284/mn-ii-oxidation-by-the-multicopper-oxidase-complex-mnx-a-binuclear-activation-mechanism
#11
Alexandra V Soldatova, Lizhi Tao, Christine A Romano, Troy A Stich, William H Casey, R David Britt, Bradley M Tebo, Thomas G Spiro
The bacterial protein complex Mnx contains a multicopper oxidase (MCO) MnxG that, unusually, catalyzes the two-electron oxidation of Mn(II) to MnO2 biomineral, via a Mn(III) intermediate. Although Mn(III)/Mn(II) and Mn(IV)/Mn(III) reduction potentials are expected to be high, we find a low reduction potential, 0.38V (pH 7.8), for the MnxG type 1 Cu(2+), the electron acceptor. Indeed the type 1 Cu(2+) is not reduced by Mn(II) in the absence of molecular oxygen, indicating that substrate oxidation requires an activation step...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28708375/enzyme-that-makes-you-cry-crystal-structure-of-lachrymatory-factor-synthase-from-allium-cepa
#12
Josie A Silvaroli, Matthew J Pleshinger, Surajit Banerjee, Philip D Kiser, Marcin Golczak
The biochemical pathway that gives onions their savor is part of the chemical warfare against microbes and animals. This defense mechanism involves formation of a volatile lachrymatory factor (LF) ((Z)-propanethial S-oxide) that causes familiar eye irritation associated with onion chopping. LF is produced in a reaction catalyzed by lachrymatory factor synthase (LFS). The principles by which LFS facilitates conversion of a sulfenic acid substrate into LF have been difficult to experimentally examine owing to the inherent substrate reactivity and lability of LF...
July 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28707639/life-in-unexpected-places-employing-visual-thinking-strategies-in-global-health-training
#13
Jill Allison, Shree Mulay, Monica Kidd
BACKGROUND: The desire to make meaning out of images, metaphor, and other representations indicates higher-order cognitive skills that can be difficult to teach, especially in the complex and unfamiliar environments like those encountered in many global health experiences. Because reflecting on art can help develop medical students' imaginative and interpretive skills, we used visual thinking strategies (VTS) during an immersive 4-week global health elective for medical students to help them construct new understanding of the social determinants of health in a low-resource setting...
January 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28706190/clean-power-generation-from-the-intractable-natural-coalfield-fires-turn-harm-into-benefit
#14
Bobo Shi, Hetao Su, Jinshi Li, Haining Qi, Fubao Zhou, José L Torero, Zhongwei Chen
The coal fires, a global catastrophe for hundreds of years, have been proved extremely difficult to control, and hit almost every coal-bearing area globally. Meanwhile, underground coal fires contain tremendous reservoir of geothermal energy. Approximately one billion tons of coal burns underground annually in the world, which could generate ~1000 GW per annum. A game-changing approach, environmentally sound thermal energy extraction from the intractable natural coalfield fires, is being developed by utilizing the waste energy and reducing the temperature of coalfield fires at the same time...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28703926/difficult-conversations-adults-with-diabetes-and-the-discussion-of-microvascular-complications
#15
M D Ritholz, T MacNeil, K Weinger
AIMS: To investigate the experiences among adults with diabetes of discussions of microvascular complications and provide recommendations for providers. METHODS: We performed a qualitative study in 148 adults with Type 1 and Type 2 diabetes (56% women, 95% white, mean age 60±13 years, 65% with Type 1 diabetes, 71% with ≥1 microvascular complication). Data were analysed using content analysis. RESULTS: At their first discussion of microvascular complications, 93% of participants (138/148) recalled providers using a preventative approach including clinical suggestions, factual information and warnings...
July 13, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28701767/actomyosin-and-vimentin-cytoskeletal-networks-regulate-nuclear-shape-mechanics-and-chromatin-organization
#16
Michael C Keeling, Luis R Flores, Asad H Dodhy, Elizabeth R Murray, Núria Gavara
The regulation of nuclear state by the cytoskeleton is an important part of cellular function. Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary roles in integrating the nucleus into its environment and influencing its mechanical state. However, the interconnectedness of cytoskeletal networks makes it difficult to dissect their individual effects on the nucleus. We use simple image analysis approaches to characterize nuclear state, estimating nuclear volume, Poisson's ratio, apparent elastic modulus and chromatin condensation...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694336/magnified-neural-envelope-coding-predicts-deficits-in-speech-perception-in-noise
#17
Rebecca E Millman, Sven L Mattys, André D Gouws, Garreth Prendergast
Verbal communication in noisy backgrounds is challenging. Understanding speech in background noise that fluctuates in intensity over time is particularly difficult for hearing-impaired listeners with a sensorineural hearing loss (SNHL). The reduction in fast-acting cochlear compression associated with SNHL exaggerates the perceived fluctuations in intensity in amplitude-modulated sounds. SNHL-induced changes in the coding of amplitude-modulated sounds may have a detrimental effect on the ability of SNHL listeners to understand speech in the presence of modulated background noise...
July 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28690000/-i-m-not-gonna-pull-the-rug-out-from-under-you-patient-provider-communication-about-opioid-tapering
#18
Marianne S Matthias, Nicole L Johnson, Cleveland G Shields, Matthew J Bair, Palmer MacKie, Monica Huffman, Stewart C Alexander
In response to increases in harms associated with prescription opioids, opioid prescribing has come under greater scrutiny, leading many healthcare organizations and providers to consider or mandate opioid dose reductions (tapering) for patients with chronic pain. Communicating about tapering can be difficult, particularly for patients on long-term opioids who perceive benefits and are using their medications as prescribed. Given the importance of effective patient-provider communication for pain management and recent health system-level initiatives and provider practices to taper opioids, this study used qualitative methods to understand communication processes related to opioid tapering, to identify best practices and opportunities for improvement...
July 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28687607/synaptotagmin-isoforms-confer-distinct-activation-kinetics-and-dynamics-to-chromaffin-cell-granules
#19
Tejeshwar C Rao, Zuleirys Santana Rodriguez, Mazdak M Bradberry, Alexandra H Ranski, Peter J Dahl, Michael W Schmidtke, Paul M Jenkins, Daniel Axelrod, Edwin R Chapman, David R Giovannucci, Arun Anantharam
Adrenomedullary chromaffin cells respond to sympathetic nervous system activation by secreting a cocktail of potent neuropeptides and hormones into the circulation. The distinct phases of the chromaffin cell secretory response have been attributed to the progressive fusion of distinct populations of dense core granules with different activation kinetics. However, it has been difficult to define what distinguishes these populations at the molecular level. Functional segregation of granule pools may depend on selective sorting of synaptotagmin-1 (Syt-1) and synaptotagmin-7 (Syt-7), which our previous work showed are rarely cosorted to the same granule...
July 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28681886/aromatic-c-h-amination-a-radical-approach-for-adding-new-functions-into-biology-and-materials-oriented-aromatics
#20
Kei Murakami, Gregory J P Perry, Kenichiro Itami
C-H amination is the most powerful method to directly add nitrogen functionalities into a variety of arenes including biology- and materials-oriented molecules. Recent developments in aromatic C-H amination chemistry have enabled the conversion of unactivated arenes into a range of arylamine derivatives without using directing groups or excess amounts of arenes. The key for such successful transformations is the catalytic generation of nitrogen or arene radical intermediates. In this perspective, we discuss recent developments in the radical C-H amination of aromatic molecules...
July 6, 2017: Organic & Biomolecular Chemistry
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