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https://www.readbyqxmd.com/read/28932537/the-role-of-video-assisted-thoracoscopic-surgery-for-management-of-symptomatic-pleural-effusion-after-coronary-artery-bypass-surgery-a-best-evidence-topic-report
#1
REVIEW
Alfonso Fiorelli, Francesco Caronia, Aldo Prencipe, Mario Santini, Brendon Stiles
A best evidence topic in thoracic surgery was written addressing whether video-assisted thoracoscopic surgery (VATS) talc pleurodesis could be justified in patients with pleural effusion (PE) after coronary artery bypass graft (CABG) surgery and no-responded to repeated thoracentesis. Ten papers were identified to answer the question. Of these, two were case-series study including ≥4 patients, 7 retrospective analytical studies, and one observational study but no randomized controlled trial (RCTs) was included in the analysis...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28930765/encouraging-reflexivity-in-a-residency-leadership-development-program-expanding-outside-the-competency-approach
#2
Justin T Clapp, Emily K B Gordon, Dimitry J Baranov, Beulah Trey, Felice Y Tilin, Lee A Fleisher
PROBLEM: While leadership development is increasingly a goal of academic medicine, it is typically framed as competency acquisition, which can limit its focus to a circumscribed set of social behaviors. This orientation may also reinforce the cultural characteristics of academic medicine that can make effective leadership difficult, rather than training leaders capable of examining and changing this culture. Expanding leadership development so it promotes social reflexivity presents a way to bolster some of the weaknesses of the competency paradigm...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28928329/single-incision-trocar-less-endoscopic-management-of-giant-liver-hydatid-cyst-in-children
#3
Himanshu Acharya, Vikesh Agrawal, Abhishek Tiwari, Dhananjaya Sharma
INTRODUCTION: Laparoscopic management of giant hydatid cyst has limitations such as spillage, poor control, difficulties in suctioning the contents through special ports which are not easily available, difficulty in the obliteration of residual cavity and recurrence. We describe single-incision trocar-less endoscopic (SITE) technique which simplifies enucleation and management of residual cavity. METHOD: Inclusion criteria for these cases were patients having single uncomplicated giant hydatid cyst >5 cm present at the surface of the liver and palpable on clinical examination...
September 20, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28923492/rationale-and-design-of-the-atrial-fibrillation-health-literacy-information-technology-trial-af-litt
#4
Emily N Guhl, Courtney L Schlusser, Lori E Henault, Timothy W Bickmore, Everlyne Kimani, Michael K Paasche-Orlow, Jared W Magnani
BACKGROUND: Atrial Fibrillation (AF) is a common cardiac arrhythmia that is challenging for patients and adversely impacts health-related quality of life (HRQoL). Long-term management of AF requires that patients adhere to complex therapies, understand difficult terminology, navigate subspecialty care, and have continued symptom monitoring with the goal of preventing adverse outcomes. Continued interventions to ameliorate the patient experience of AF are essential. DESIGN: The Atrial Fibrillation health Literacy Information Technology Trial (AF-LITT; NCT03093558) is an investigator-initiated, 2-arm randomized clinical trial (RCT)...
September 15, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28918952/a-dual-function-for-prickle-in-regulating-frizzled-stability-during-feedback-dependent-amplification-of-planar-polarity
#5
Samantha J Warrington, Helen Strutt, Katherine H Fisher, David Strutt
The core planar polarity pathway coordinates epithelial cell polarity during animal development, and loss of its activity gives rise to a range of defects, from aberrant morphogenetic cell movements to failure to correctly orient structures, such as hairs and cilia. The core pathway functions via a mechanism involving segregation of its protein components to opposite cells ends, where they form asymmetric intracellular complexes that couple cell-cell polarity. This segregation is a self-organizing process driven by feedback interactions between the core proteins themselves...
September 7, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28916894/critical-appraisal-of-the-impact-of-individual-surgeon-experience-on-the-outcomes-of-laparoscopic-liver-resection-in-the-modern-era-collective-experience-of-multiple-surgeons-at-a-single-institution-with-324-consecutive-cases
#6
Brian K P Goh, Jin-Yao Teo, Ser-Yee Lee, Juinn-Huar Kam, Peng-Chung Cheow, Premaraj Jeyaraj, Pierce K H Chow, London L P J Ooi, Alexander Y F Chung, Chung-Yip Chan
BACKGROUND: Most studies analyzing the learning experience of laparoscopic liver resection (LLR) focused on the experience of one or two expert pioneering surgeons. This study aims to critically analyze the impact of individual surgeon experience on the outcomes of LLR based on the contemporary collective experiences of multiple surgeons at single institution. METHODS: Retrospective review of 324 consecutive LLR from 2006 to 2016. The cases were performed by 10 surgeons over various time periods...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916868/laparoscopic-liver-resection-using-a-monopolar-soft-coagulation-device-to-provide-maximum-intraoperative-bleeding-control-for-the-treatment-of-hepatocellular-carcinoma
#7
Mitsuo Miyazawa, Masayasu Aikawa, Katsuya Okada, Yukihiro Watanabe, Kojun Okamoto, Isamu Koyama
BACKGROUND: The popularity of laparoscopic liver resection (LLR) is spreading, worldwide, because the intraoperative blood loss is less than for open hepatectomy and it is associated with a shorter hospitalization period [1-6]. During LLR, intraoperative hemostasis is difficult to achieve, unlike during laparotomy where bleeding can be stopped instantly [7-10]. Our LLR method for the treatment of hepatocellular carcinoma (HCC) includes maximal control of intraoperative bleeding using a monopolar soft-coagulation device...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28913654/discriminating-cirrnas-from-other-lncrnas-using-a-hierarchical-extreme-learning-machine-h-elm-algorithm-with-feature-selection
#8
Lei Chen, Yu-Hang Zhang, Guohua Huang, Xiaoyong Pan, ShaoPeng Wang, Tao Huang, Yu-Dong Cai
As non-coding RNAs, circular RNAs (cirRNAs) and long non-coding RNAs (lncRNAs) have attracted an increasing amount of attention. They have been confirmed to participate in many biological processes, including playing roles in transcriptional regulation, regulating protein-coding genes, and binding to RNA-associated proteins. Until now, the differences between these two types of non-coding RNAs have not been fully uncovered. It is still quite difficult to detect cirRNAs from other lncRNAs using simple techniques...
September 14, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28899810/quantity-discrimination-in-canids-dogs-canis-familiaris-and-wolves-canis-lupus-compared
#9
Miletto Petrazzini Maria Elena, Clive D L Wynne
Accumulating evidence indicates that animals are able to discriminate between quantities. Recent studies have shown that dogs' and coyotes' ability to discriminate between quantities of food items decreases with increasing numerical ratio. Conversely, wolves' performance is not affected by numerical ratio. Cross-species comparisons are difficult because of differences in the methodologies employed, and hence it is still unclear whether domestication altered quantitative abilities in canids. Here we used the same procedure to compare pet dogs and wolves in a spontaneous food choice task...
September 9, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28898578/an-alternatively-packed-dry-molten-globule-like-intermediate-in-the-native-state-ensemble-of-a-multi-domain-protein
#10
Prajna Mishra, Santosh Kumar Jha
It has been difficult to quantify the degree of side-chain conformational heterogeneity in the native (N) state ensemble of proteins and the relative energetic contributions of the side-chain packing and the hydrophobic effect in protein stability. Here, we show using multiple site-specific spectroscopic probes and tools of thermodynamics that the N state ensemble of a multi-domain protein contains an equilibrium intermediate (I) whose inter-domain region resembles a dry molten globule. In the I state, a tryptophan residue in the inter-domain region is alternatively packed but its secondary structure and intra-domain packing are N-like...
September 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28892681/optimization-of-the-yield-of-dark-microaerobic-production-of-hydrogen-from-lactate-by-rhodopseudomonas-palustris
#11
Carolina Zampol Lazaro, Zeynep Yilmazer Hitit, Patrick C Hallenbeck
Hydrogen yields of dark fermentation are limited due to the need to also produce reduced side products, and photofermentation, an alternative, is limited by the need for light. A relatively new strategy, dark microaerobic fermentation, could potentially overcome both these constraints. Here, application of this strategy demonstrated for the first time significant hydrogen production from lactate by a single organism in the dark. Response surface methodology (RSM) was used to optimize substrate and oxygen concentration as well as inoculum using both (1) regular batch and (2) O2 fed batch cultures...
September 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28890950/creating-conditions-for-patients-values-to-emerge-in-clinical-conversations-perspectives-of-health-care-team-members
#12
Andrew B L Berry, Catherine Lim, Andrea L Hartzler, Tad Hirsch, Evette Ludman, Edward H Wagner, James D Ralston
Eliciting, understanding, and honoring patients' values- the things most important to them in daily life-is a cornerstone of patient-centered care. However, this rarely occurs explicitly as a routine part of clinical practice. This is particularly problematic for individuals with multiple chronic conditions (MCC) because they face difficult choices about how to balance competing demands for self-care in accordance with their values. In this study, we sought to inform the design of interventions to support conversations about patient values between patients with MCC and their health care providers...
June 2017: DIS (Des Interact Syst Conf)
https://www.readbyqxmd.com/read/28890780/recellularization-of-decellularized-heart-valves-progress-toward-the-tissue-engineered-heart-valve
#13
REVIEW
Mitchell C VeDepo, Michael S Detamore, Richard A Hopkins, Gabriel L Converse
The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance as a stand-alone implant, and partial recellularization in vivo. However, a significant challenge remains in realizing the tissue-engineered heart valve: assuring consistent recellularization of the entire valve leaflets by phenotypically appropriate cells...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28888759/impact-of-iliac-artery-anatomy-on-the-outcome-of-fenestrated-and-branched-endovascular-aortic-repair
#14
Enrico Gallitto, Mauro Gargiulo, Gianluca Faggioli, Rodolfo Pini, Chiara Mascoli, Antonio Freyrie, Stefano Ancetti, Andrea Stella
OBJECTIVE: Fenestrated and branched endovascular aneurysm repair (FB-EVAR) is a valid option to treat juxtarenal and pararenal abdominal aortic aneurysms and thoracoabdominal aortic aneurysms. Because successful deployment depends on complex maneuvers, hostile iliac artery anatomy (HIA) can prejudice the FB-EVAR outcome. The aim of the study was to evaluate the impact of HIA on FB-EVAR outcome. METHODS: Between 2010 and 2015, all patients undergoing FB-EVAR were prospectively categorized according to iliac anatomy (friendly iliac artery anatomy [FIA] or HIA)...
September 6, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28878820/saccharomyces-cerevisiae-strain-comparison-in-glucose-xylose-fermentations-on-defined-substrates-and-in-high-gravity-sscf-convergence-in-strain-performance-despite-differences-in-genetic-and-evolutionary-engineering-history
#15
Vera Novy, Ruifei Wang, Johan O Westman, Carl Johan Franzén, Bernd Nidetzky
BACKGROUND: The most advanced strains of xylose-fermenting Saccharomyces cerevisiae still utilize xylose far less efficiently than glucose, despite the extensive metabolic and evolutionary engineering applied in their development. Systematic comparison of strains across literature is difficult due to widely varying conditions used for determining key physiological parameters. Here, we evaluate an industrial and a laboratory S. cerevisiae strain, which has the assimilation of xylose via xylitol in common, but differ fundamentally in the history of their adaptive laboratory evolution development, and in the cofactor specificity of the xylose reductase (XR) and xylitol dehydrogenase (XDH)...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28876236/auspex-a-graphical-tool-for-x-ray-diffraction-data-analysis
#16
Andrea Thorn, James Parkhurst, Paul Emsley, Robert A Nicholls, Melanie Vollmar, Gwyndaf Evans, Garib N Murshudov
In this paper, AUSPEX, a new software tool for experimental X-ray data analysis, is presented. Exploring the behaviour of diffraction intensities and the associated estimated uncertainties facilitates the discovery of underlying problems and can help users to improve their data acquisition and processing in order to obtain better structural models. The program enables users to inspect the distribution of observed intensities (or amplitudes) against resolution as well as the associated estimated uncertainties (sigmas)...
September 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28875782/improving-communication-with-families-in-the-intensive-care-unit
#17
Deborah Briggs
Families ('family' will be used in this article to refer to anyone the patient considers significant, whether they are an actual family member or not) of patients who are critically ill have heightened communication needs. Nurses are an important source of information, particularly about day-to-day patient events and progress. Intensive care unit (ICU) nurses are valued by families because they provide clear, jargon-free information about the patient and their condition. However, they have sometimes been criticised for focusing on short-term issues while avoiding potentially difficult conversations about long-term outcomes and prognosis...
September 6, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28871271/somatic-embryogenesis-in-coffee-the-evolution-of-biotechnology-and-the-integration-of-omics-technologies-offer-great-opportunities
#18
REVIEW
Nádia A Campos, Bart Panis, Sebastien C Carpentier
One of the most important crops cultivated around the world is coffee. There are two main cultivated species, Coffea arabica and C. canephora. Both species are difficult to improve through conventional breeding, taking at least 20 years to produce a new cultivar. Biotechnological tools such as genetic transformation, micropropagation and somatic embryogenesis (SE) have been extensively studied in order to provide practical results for coffee improvement. While genetic transformation got many attention in the past and is booming with the CRISPR technology, micropropagation and SE are still the major bottle neck and urgently need more attention...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28870855/growth-media-in-anaerobic-fermentative-processes-the-underestimated-potential-of-thermophilic-fermentation-and-anaerobic-digestion
#19
REVIEW
A T W M Hendriks, J B van Lier, M K de Kreuk
Fermentation and anaerobic digestion of organic waste and wastewater is broadly studied and applied. Despite widely available results and data for these processes, comparison of the generated results in literature is difficult. Not only due to the used variety of process conditions, but also because of the many different growth media that are used. Composition of growth media can influence biogas production (rates) and lead to process instability during anaerobic digestion. To be able to compare results of the different studies reported, and to ensure nutrient limitation is not influencing observations ascribed to process dynamics and/or reaction kinetics, a standard protocol for creating a defined growth medium for anaerobic digestion and mixed culture fermentation is proposed...
September 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28870710/communication-skills-training-in-ophthalmology-results-of-a-needs-assessment-and-pilot-training-program
#20
Anuradha Mishra, David Browning, Miriam J Haviland, Mary Lou Jackson, Donna Luff, Elaine C Meyer, Katherine Talcott, Carolyn E Kloek
OBJECTIVE: To conduct a needs assessment to identify gaps in communication skills training in ophthalmology residency programs and to use these results to pilot a communication workshop that prepares residents for difficult conversations. DESIGN: A mixed-methods design was used to perform the needs assessment. A pre-and postsurvey was administered to workshop participants. SETTING: Mass Eye and Ear Infirmary, Harvard Medical School (HMS), Department of Ophthalmology...
September 1, 2017: Journal of Surgical Education
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