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https://www.readbyqxmd.com/read/29146387/dilemmas-in-genetic-counseling-for-low-penetrance-neuro-susceptibility-loci-detected-on-prenatal-chromosomal-microarray-analysis
#1
Dana Brabbing-Goldstein, Adi Reches, Ran Svirsky, Anat Bar-Shira, Yuval Yaron
BACKGROUND: Chromosomal microarray analysis is standard of care in fetuses with malformations, detecting clinically significant copy number variants in 5-7% of cases over conventional karyotyping. However, it also detects variants of uncertain significance in 1.6% - 4.2% of the cases, some of which are low-penetrance neuro-susceptibility loci. The interpretation of these variants in pregnancy is particularly challenging, because the significance is often unclear and the clinical implications may be difficult to predict...
November 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29145130/photophysical-and-photochemical-insights-into-the-photodegradation-of-sulfapyridine-in-water-a-joint-experimental-and-theoretical-study
#2
Heming Zhang, Xiaoxuan Wei, Xuedan Song, Shaheen Shah, Jingwen Chen, Jianhui Liu, Ce Hao, Zhongfang Chen
For organic pollutants, photodegradation, as a major abiotic elimination process and of great importance to the environmental fate and risk, involves rather complicated physical and chemical processes of excited molecules. Herein, we systematically studied the photophysical and photochemical processes of a widely used antibiotic, namely sulfapyridine. By means of density functional theory (DFT) computations, we examined the rate constants and the competition of both photophysical and photochemical processes, elucidated the photochemical reaction mechanism, calculated reaction quantum yield (Φ) based on both photophysical and photochemical processes, and subsequently estimated the photodegradation rate constant...
October 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29140656/an-analysis-of-%C3%A2-natural%C3%A2-food-litigation-to-build-a-sesame-allergy-consumer-class-action
#3
Dana Shaker
In a world where food allergy is still an incurable disease, law and regulation stand as necessary mechanisms to provide food-allergic consumers with the information they need to protect their health. The Food Allergen Labeling and Consumer Protection Act of 2004 provided specific labeling requirements for the “Top Eight” allergens in the U.S.: milk, soy, gluten, egg, tree nut, peanut, fish, and Crustacean shellfish. Since then, sesame has become more prevalent as an allergen and remains just as dangerous, inducing anaphylactic shock in some sesame-allergic individuals...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29137720/improving-surgical-residents-communication-in-disclosing-complications-a-qualitative-analysis-of-simulated-physician-and-patient-surrogate-conversations
#4
Carolina Fernandez Branson, Jeffrey G Chipman
BACKGROUND: In this study, we explore surgical resident communication with simulated patient surrogates (SPs), in an Objective Structured Clinical Examination (OSCE). METHODS: We use discourse analysis (DA), a qualitative approach to analyzing language, to evaluate our residents' interactions with simulated patient surrogates. After identifying problematic communication patterns, we apply communication theory to discuss our findings and provide suggestions for improvement...
November 7, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29134384/totally-robotic-single-docking-low-anterior-resection-for-rectal-cancer-pearls-and-pitfalls
#5
J W T Toh, A Zakaria, I Yang, S H Kim
Total robotic resection of mid- and low rectal cancers confers technical advantages within the confines of the pelvis and allows difficult rectal cancer cases to be performed efficiently with less risk of conversion to open. To maximize the advantage of robotic surgery, we utilize the technique of single docking totally robotic dissection for rectal cancer for both the Da Vinci Si and Xi Surgical Systems. All steps are performed robotically, with the surgery divided into two phases. The first phase consists of inferior mesenteric artery and vein ligation, sigmoid and descending colon mobilization and splenic flexure takedown...
November 13, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29131488/dorsal-root-ganglion-stimulation-used-for-the-treatment-of-chronic-neuropathic-pain-in-the-groin-a-single-center-study-with-long-term-prospective-results-in-34-cases
#6
Matthias Hubert Morgalla, Anil Bolat, Marcos Fortunato, Guilherme Lepski, Bankim Subhash Chander
OBJECTIVE: Chronic neuropathic pain in the groin is a severe condition and difficult to treat. Dorsal root ganglion stimulation (DRGS) covers discrete painful areas precisely with its stimulation power in comparison to spinal cord stimulation (SCS). It was our hypothesis that DRGS provides a long-term relief of chronic groin pain over a period of more than three years. MATERIALS AND METHODS: Patients (age >18 years) with chronic neuropathic groin pain were prospectively examined...
November 13, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29128988/employing-community-voices-informing-practice-and-programming-through-camden-healthy-start-focus-groups
#7
Dianne R Browne, Sherolde Hackett, Allison Burger
Objectives Women living in communities with low-socioeconomic status, substandard healthcare, and ongoing exposure to social disparities encounter barriers to healthcare, often making it difficult to access health services. Barriers may stem from provider interactions with clients, conditions of the healthcare facility, or even language barriers. This prompts a call for providers to be keenly aware of the obstacles women encounter when attempting to access services. Methods In an effort to facilitate better access to services, Camden Healthy Start conducted six focus groups...
November 11, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29127795/an-investigation-of-the-leaf-retention-capacity-efficiency-and-mechanism-for-atmospheric-particulate-matter-of-five-greening-tree-species-in-beijing-china
#8
Jinqiang Liu, Zhiguo Cao, Songyan Zou, Huanhuan Liu, Xiao Hai, Shihua Wang, Jie Duan, Benye Xi, Guangxuan Yan, Shaowei Zhang, Zhongkui Jia
Urban trees have the potential to reduce air pollution, but the retention capacity and efficiency of different tree species for atmospheric particulate matter (PM) accumulation and the underlying mechanism hasn't been well understood. To select tree species with high air purification abilities, the supplementing ultrasonic cleaning (UC) procedure was first introduced into the conventional leaf cleaning methods [single water cleaning (WC) or plus brush cleaning (BC)] for eluting the leaf-retained PM. Further updates to the methodology were applied to investigate the retention capacity, efficiency, and mechanism for PM of five typical greening tree species in Beijing, China...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29125746/selective-activation-of-methane-on-single-atom-catalyst-of-rhodium-dispersed-on-zirconia-for-direct-conversion
#9
Yongwoo Kwon, Tae Yong Kim, Gihun Kwon, Jongheop Yi, Hyunjoo Lee
Direct methane conversion into value-added products becomes more important. Due to inertness of methane, cleaving the first C-H bond has been very difficult requiring high reaction temperature on the heterogeneous catalysts. Once the first C-H bond becomes activated, the remaining C-H bonds are successively dissociated on the metal surface, hindering the direct methane conversion into chemicals. Here, a single-atom Rh catalyst dispersed on ZrO2 surface has been synthesized and used for selective activation of methane...
November 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29121933/biochemical-analysis-and-the-preliminary-crystallographic-characterization-of-d-tagatose-3-epimerase-from-rhodobacter-sphaeroides
#10
Zhengliang Qi, Zhangliang Zhu, Jian-Wen Wang, Songtao Li, Qianqian Guo, Panpan Xu, Fuping Lu, Hui-Min Qin
BACKGROUND: D-Tagatose 3-epimerase epimerizes D-fructose to yield D-psicose, which is a rare sugar that exists in small quantities in nature and is difficult to synthesize chemically. We aim to explore potential industrial biocatalysts for commercial-scale manufacture of this rare sugar. A D-tagatose 3-epimerase from Rhodobacter sphaeroides (RsDTE) has recently been identified as a D-tagatose 3-epimerase that can epimerize D-fructose to yield D-psicose with a high conversion rate. RESULTS: The purified RsDTE by Ni-affinity chromatography, ionic exchange chromatography and gel filtration forms a tetramer in solution...
November 9, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29121812/risk-assessment-interviews-exploring-the-perspectives-of-psychologists-and-indeterminate-sentenced-prisoners-in-the-united-kingdom
#11
Jo Shingler, Stefanie J Sonnenberg, Adrian Needs
This study explores the forensic risk assessment interview from the perspectives of qualified prison-based psychologists and indeterminate sentenced prisoners in the United Kingdom. It focuses on the psychologist-prisoner relationship in the interview context. Twenty-one in-depth individual interviews were conducted with psychologists and prisoners and analysed using Grounded Theory methods. The analysis identified the following categories reflecting participants' descriptions of risk assessment interviews: "Emphasising Clarity and Transparency," "Collaborative Engagement," "Making a Respectful, Boundaried yet Human Connection," "Respecting Individuality," and "Having a Purposeful Conversation...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29121247/prediction-of-individual-outcomes-for-asthma-sufferers
#12
B Storlie Curtis, E Branda Megan, R Gionfriddo Michael, D Shah Nilay, A Rank Matthew
We consider the problem of individual-specific medication level recommendation (initiation, removal, increase, or decrease) for asthma sufferers. Asthma is one of the most common chronic diseases in both adults and children, affecting 8% of the US population and costing $37-63 billion/year in the United States of America. Asthma is a complex disease, whose symptoms may wax and wane, making it difficult for clinicians to predict outcomes and prognosis. Improved ability to predict prognosis can inform decision making and may promote conversations between clinician and provider around optimizing medication therapy...
November 6, 2017: Biostatistics
https://www.readbyqxmd.com/read/29118851/targeted-metatranscriptomics-of-compost-derived-consortia-reveals-a-gh11-exerting-an-unusual-exo-1-4-%C3%AE-xylanase-activity
#13
Bruno L Mello, Anna M Alessi, Diego M Riaño-Pachón, Eduardo R deAzevedo, Francisco E G Guimarães, Melissa C Espirito Santo, Simon McQueen-Mason, Neil C Bruce, Igor Polikarpov
Background: Using globally abundant crop residues as a carbon source for energy generation and renewable chemicals production stand out as a promising solution to reduce current dependency on fossil fuels. In nature, such as in compost habitats, microbial communities efficiently degrade the available plant biomass using a diverse set of synergistic enzymes. However, deconstruction of lignocellulose remains a challenge for industry due to recalcitrant nature of the substrate and the inefficiency of the enzyme systems available, making the economic production of lignocellulosic biofuels difficult...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29118100/-difficult-conversations-evaluation-of-multiprofessional-training
#14
Lisa Jane Brighton, Lucy Ellen Selman, Nicholas Gough, J J Nadicksbernd, Katherine Bristowe, Catherine Millington-Sanders, Jonathan Koffman
OBJECTIVES: Evidence-based communication skills training for health and social care professionals is essential to improve the care of seriously ill patients and their families. We aimed to evaluate the self-reported impact of 'Difficult Conversations', a multidisciplinary half-day interactive workshop, and gain feedback to inform future development and evaluation. METHODS: Service evaluation using questionnaire data collected before and immediately after workshops from February 2015 to August 2016 regarding participant self-assessed confidence, knowledge and skills...
November 8, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29116758/robust-stacking-independent-ultrafast-charge-transfer-in-mos2-ws2-bilayers
#15
Ziheng Ji, Hao Hong, Jin Zhang, Qi Zhang, Wei Huang, Ting Cao, Ruixi Qiao, Can Liu, Jing Liang, Chuanhong Jin, Liying Jiao, Kebin Shi, Sheng Meng, Kaihui Liu
Van der Waals-coupled two-dimensional (2D) heterostructures have attracted great attentions recently due to their high potential in the next-generation photodetectors and solar cells. The understanding of charge-transfer process between adjacent atomic layers is the key to design optimal devices as it directly determines the fundamental response speed and photon-electron conversion efficiency. However, general belief and theoretical studies have shown that the charge transfer behaviour depends sensitively on interlayer configurations, which is difficult to control accurately, bringing great uncertainties in device designing...
November 8, 2017: ACS Nano
https://www.readbyqxmd.com/read/29103336/procalcitonin-performance-in-detecting-serious-and-invasive-bacterial-infections-in-children-with-fever-without-apparent-source-a-systematic-review-and-meta-analysis
#16
Giulia Trippella, Luisa Galli, Maurizio De Martino, Catiuscia Lisi, Elena Chiappini
The management of children with fever without apparent sources (FWAS) is difficult. This study aimed to evaluate the diagnostic accuracy of procalcitonin (PCT) in detecting serious or invasive bacterial infection (SBI or IBI) in children with FWAS. Areas covered: A systematic review of literature from 2007 to 2017 was performed on Medline. Twelve studies were included, involving 7,260 children with FWAS and analyzing the diagnostic performance of PCT. Four meta-analyses were performed to calculate pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic curve for PCT in detecting SBI and IBI, at two different thresholds...
November 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29103168/fusion-of-dna-binding-domain-of-pyrococcus-furiosus-ligase-with-taqstoffel-dna-polymerase-as-a-useful-tool-in-pcr-with-difficult-targets
#17
Marta Śpibida, Beata Krawczyk, Beata Zalewska-Piątek, Rafał Piątek, Magdalena Wysocka, Marcin Olszewski
The DNA coding sequence of TaqStoffel polymerase was fused with the DNA-binding domain of Pyrococcus furiosus ligase. The resulting novel recombinant gene was cloned and expressed in E. coli. The recombinant enzyme was purified and its enzymatic features were studied. The fusion protein (PfuDBDlig-TaqS) was found to have enhanced processivity as a result of the conversion of the TaqDNA polymerase from a relatively low processive to a highly processive enzyme. The abovementioned processivity enhancement was about threefold as compared to the recombinant TaqStoffel DNA polymerase (TaqS), and the recombinant fusion protein was more thermostable...
November 4, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29098931/ante-mortem-detection-of-chronic-wasting-disease-in-recto-anal-mucosa-associated-lymphoid-tissues-from-elk-cervus-elaphus-nelsoni-using-real-time-quaking-induced-conversion-rt-quic-assay-a-blinded-collaborative-study
#18
Sireesha Manne, Naveen Kondru, Tracy Nichols, Aaron Lehmkuhl, Bruce Thomsen, Rodger Main, Patrick Halbur, Somak Dutta, Anumantha G Kanthasamy
Prion diseases are transmissible spongiform encephalopathies (TSEs) characterized by fatal, progressive neurologic diseases with prolonged incubation periods and an accumulation of infectious misfolded prion proteins. Antemortem diagnosis is often difficult due to a long asymptomatic incubation period, differences in the pathogenesis of different prions, and the presence of very low levels of infectious prion in easily accessible samples. Chronic wasting disease (CWD) is a TSE affecting both wild and captive populations of cervids, including mule deer, white-tailed deer, elk, moose, muntjac, and most recently, wild reindeer...
November 3, 2017: Prion
https://www.readbyqxmd.com/read/29096369/in-vitro-anti-biofilm-activity-of-a-biphasic-gentamicin-loaded-calcium-sulfate-hydroxyapatite-bone-graft-substitute
#19
Maria Eugenia Butini, Sabrina Cabric, Andrej Trampuz, Mariagrazia Di Luca
Bone and implant-associated infections caused by microorganisms that grow in biofilms are difficult to treat because of persistence and recurrence of infection. Along with surgical debridement, the combination of systemic and local administration of antimicrobials represents the background for an efficient treatment strategy. Gentamicin is one of most used antibiotics for the local treatment of bone-related infections, alone or in combination, due to its bactericidal and broad-range activity. Gentamicin-loaded beads (GLBs), composed of calcium sulfate/hydroxyapatite, were assessed for their in vitro antimicrobial activity against planktonic and biofilm S...
October 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29095575/tokyo-guidelines-2018-surgical-management-of-acute-cholecystitis-safe-steps-in-laparoscopic-cholecystectomy-for-acute-cholecystitis-with-videos
#20
Go Wakabayashi, Yukio Iwashita, Taizo Hibi, Tadahiro Takada, Steven M Strasberg, Horacio J Asbun, Itaru Endo, Akiko Umezawa, Koji Asai, Kenji Suzuki, Yasuhisa Mori, Kohji Okamoto, Henry A Pitt, Ho-Seong Han, Tsann-Long Hwang, Yoo-Seok Yoon, Dong-Sup Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Mariano Eduardo Giménez, O James Garden, Dirk J Gouma, Giulio Belli, Christos Dervenis, Palepu Jagannath, Angus C W Chan, Wan Yee Lau, Keng-Hao Liu, Cheng-Hsi Su, Takeyuki Misawa, Masafumi Nakamura, Akihiko Horiguchi, Nobumi Tagaya, Shuichi Fujioka, Ryota Higuchi, Satoru Shikata, Yoshinori Noguchi, Tomohiko Ukai, Masamichi Yokoe, Daniel Cherqui, Goro Honda, Atsushi Sugioka, Eduardo de Santibañes, Avinash Nivritti Supe, Hiromi Tokumura, Taizo Kimura, Masahiro Yoshida, Toshihiko Mayumi, Seigo Kitano, Masafumi Inomata, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
In some cases, laparoscopic cholecystectomy (LC) may be difficult to perform in patients with acute cholecystitis (AC) with severe inflammation and fibrosis. The Tokyo Guidelines 2018 (TG18) expand the indications for LC under difficult conditions for each level of severity of AC. As a result of expanding the indications for LC to treat AC, it is absolutely necessary to avoid any increase in bile duct injury (BDI), particularly vasculo-biliary injury (VBI), which is known to occur at a certain rate in LC. Since the Tokyo Guidelines 2013 (TG13), an attempt has been made to assess intraoperative findings as objective indicators of surgical difficulty; based on expert consensus on these difficulty indicators, bail-out procedures (including conversion to open cholecystectomy) have been indicated for cases in which LC for AC is difficult to perform...
November 2, 2017: Journal of Hepato-biliary-pancreatic Sciences
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