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https://www.readbyqxmd.com/read/28538912/equity-promotion-policies-in-health-for-vulnerable-groups-the-role-of-the-ministry-of-health
#1
Sandra Aparecida Venâncio de Siqueira, Eliane Hollanda, José Inácio Jardim Motta
This article aims to analyze Equity Promotion Policies in Health implemented by the Ministry of Health for vulnerable groups, through the Department of Strategy and Participative Management based on race, ethnicity, gender and lifestyle markers. The three structural elements of these policies are identified as: participatory management, transversality and awareness / professional qualifications. In carrying out research for this article, different documental sources were used including: policies, videos, conferences and minutes from council meetings as well as information from health committees...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28529771/c-i%C3%A2-n-short-contacts-as-tools-for-the-construction-of-the-crystal-packing-in-the-crystal-structure-of-3-3-ethane-1-2-di-yl-bis-6-iodo-3-4-di-hydro-2h-1-3-benzoxazine
#2
Augusto Rivera, Jicli José Rojas, Jaime Ríos-Motta, Michael Bolte
The asymmetric unit of the title compound, C18H18I2N2O2, consists of one half-mol-ecule, completed by the application of inversion symmetry. The mol-ecule adopts the typical structure for this class of bis-benxozazines, characterized by an anti orientation of the two benzoxazine rings around the central C-C bond. The oxazinic ring adopts a half-chair conformation. In the crystal, mol-ecules are linked by C-I⋯N short contacts [I⋯N = 3.378 (2) Å], generating layers lying parallel to the bc plane.
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28523088/treatment-of-a-large-traumatic-encephalocele-with-titanium-mesh
#3
Alan Motta do Canto, Manuela Monteiro Pinotti, Fernando Alves Maciel, Alexandre Bossi Todeschini, Guilherme Brasileiro Aguiar, Ronaldo Rodrigues de Freitas
Encephalocele is defined as protrusion of cranial contents beyond the normal confines of the skull. Although most encephalocele cases have a congenital etiology, fractures of the skull base can cause traumatic encephalocele. In most encephalocele cases, the bone defect presents reduced dimensions and the endoscopic treatment is generally performed to reconstruct the area using mucosal and/or fat grafts. This article sought to report on a rare case of traumatic encephalocele associated with an extensive defect of the anterior skull base...
June 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28512164/time-to-positivity-of-bacteria-cultures-in-peritoneal-dialysis-fluid-evaluation-of-different-laboratory-techniques
#4
Roberta M Katzap, Vany Elisa Pagnussatti, Ana Elizabeth Figueiredo, Julia Gabriela Motta, Domingos O d'Avila, Bartira Ercília Pinheiro da Costa, Carlos Eduardo Poli-de-Figueiredo
Patients with chronic kidney disease on peritoneal dialysis (PD) are susceptible to infections, with peritonitis being the primary cause of dropout. Peritoneal fluid culture is one of the essential elements for proper diagnosis and peritonitis treatment. The aim of this study was to compare the time required to obtain a positive culture using different laboratory methods. An in vitro cross-sectional study was conducted comparing different techniques for preparation and culture of bacteria in peritoneal fluid...
May 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28500666/bioactivity-and-mineralization-of-natural-hydroxyapatite-from-cuttlefish-bone-and-bioglass%C3%A2-co-sintered-bioceramics
#5
Natascia Cozza, Felipe Monte, Walter Bonani, Pranesh Aswath, Antonella Motta, Claudio Migliaresi
In this study, bioactive hydroxyapatite-based bioceramics starting from cuttlefish bone powders have been prepared and characterized. In particular, fragmented cuttlefish bone was co-sintered with 30 wt% of Bioglass®-45S5 to synthesize hydroxyapatite-based powders with enhanced mechanical properties and bioactivity. Commercial synthetic hydroxyapatite was treated following the same procedure and used as a reference. The structure and composition of the bioceramics formulations were characterized using Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy...
May 13, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28500458/occurrence-of-vascular-lake-phenomenon-as-a-predictor-of-improved-tumor-response-in-hcc-patients-that-underwent-deb-tace
#6
Rafael Noronha Cavalcante, Felipe Nasser, Joaquim M Motta-Leal-Filho, Breno B Affonso, Francisco L Galastri, Bruna De Fina, Rodrigo G Garcia, Nelson Wolosker
PURPOSE: To evaluate incidence and predictive factors for the vascular lake phenomenon (VLP), as well as to compare local and overall tumor response in patients with and without VLP induced during DEB-TACE for HCC. METHODS: A total of 200 consecutive patients with 323 HCC nodules underwent first-session DEB-TACE from 2011 to 2014. Patients were divided in two groups, according to the presence of the VLP during DEB-TACE. Pre- and post-treatment imaging studies (CT or MRI) were performed...
May 12, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28497129/molecular-modeling-of-the-ahr-structure-and-interactions-can-shed-light-on-ligand-dependent-activation-and-transformation-mechanisms
#7
Laura Bonati, Dario Corrada, Sara Giani Tagliabue, Stefano Motta
Molecular modeling has given important contributions to elucidation of the main stages in the AhR signal transduction pathway. Despite the lack of experimentally determined structures of the AhR functional domains, information derived from homologous systems has been exploited for modeling their structure and interactions. Homology models of the AhR PASB domain have provided information on the binding cavity and contributed to elucidate species-specific differences in ligand binding. Molecular Docking simulations of the ligand binding process have given insights into differences in binding of diverse agonists, antagonists, and selective AhR modulators, and their application to virtual screening of large databases of compounds have allowed identification of novel AhR ligands...
February 2017: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/28497111/investigating-the-influence-of-biological-sex-on-the-behavioral-and-neural-basis-of-face-recognition
#8
K Suzanne Scherf, Daniel B Elbich, Natalie V Motta-Mena
There is interest in understanding the influence of biological factors, like sex, on the organization of brain function. We investigated the influence of biological sex on the behavioral and neural basis of face recognition in healthy, young adults. In behavior, there were no sex differences on the male Cambridge Face Memory Test (CFMT)+ or the female CFMT+ (that we created) and no own-gender bias (OGB) in either group. We evaluated the functional topography of ventral stream organization by measuring the magnitude and functional neural size of 16 individually defined face-, two object-, and two place-related regions bilaterally...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28495843/treating-fructose-induced-metabolic-changes-in-mice-with-high-intensity-interval-training-insights-in-the-liver-white-adipose-tissue-and-skeletal-muscle
#9
Victor Faria Motta, Thereza Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Fructose-rich caloric sweeteners induce adverse changes in the population metabolism. The study evaluated the effects of high-intensity interval training (HIIT) on a fructose feeding model, focusing on the liver, white adipose tissue (WAT), skeletal muscle, and their interplay. Male C57BL/6 mice were fed for 18 weeks one of the following diets: control (C; 5 % of total energy from fructose), or fructose (F; 55 % of total energy from fructose). In the 10th week, for an additional eight-week period the groups were divided into non-trained (NT) or HIIT groups, totaling four groups: C-NT, C-HIIT, F-NT, and F-HIIT...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28490781/identification-of-long-noncoding-rnas-deregulated-in-papillary-thyroid-cancer-and-correlated-with-braf-v600e-mutation-by-bioinformatics-integrative-analysis
#10
Lucas Goedert, Jessica Rodrigues Plaça, Cesar Seigi Fuziwara, Maiaro Cabral Rosa Machado, Desirée Rodrigues Plaça, Palloma Porto Almeida, Talita Perez Sanches, Jair Figueredo Dos Santos, Amanda Cristina Corveloni, Illy Enne Gomes Pereira, Marcela Motta de Castro, Edna Teruko Kimura, Wilson Araújo Silva, Enilza Maria Espreafico
Papillary Thyroid Cancer (PTC) is an endocrine malignancy in which BRAF(V600E) oncogenic mutation induces the most aggressive phenotype. In this way, considering that lncRNAs are arising as key players in oncogenesis, it is of high interest the identification of BRAF(V600E)-associated long noncoding RNAs, which can provide possible candidates for secondary mechanisms of BRAF-induced malignancy in PTC. In this study, we identified differentially expressed lncRNAs correlated with BRAF(V600E) in PTC and, also, extended the cohort of paired normal and PTC samples to more accurately identify differentially expressed lncRNAs between these conditions...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28476345/the-perception-of-the-patient-safety-climate-by-professionals-of-the-emergency-department
#11
Mayara Carvalho Godinho Rigobello, Rhanna Emanuela Fontenele Lima de Carvalho, Juliana Magalhães Guerreiro, Ana Paula Gobbo Motta, Elizabeth Atila, Fernanda Raphael Escobar Gimenes
AIM: The aim of this study was to assess the patient safety climate from the perspective of healthcare professionals working in the emergency department of a hospital in Brazil. BACKGROUND: Emergency departments are complex and dynamic environments. They are prone to adverse events that compromise the quality of care provided and reveal the importance of patient safety culture and climate. METHODS: This was a quantitative, descriptive, cross-sectional study...
May 2, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28456606/cyclodextrin-based-nanosponges-for-the-targeted-delivery-of-the-anti-restenotic-agent-db103-a-novel-opportunity-for-the-local-therapy-of-vessels-wall-subjected-to-percutaneous-intervention
#12
Vito Coviello, Stefania Sartini, Luca Quattrini, Cecilia Baraldi, Maria Cristina Gamberini, Concettina La Motta
Nano-sized colloidal carriers represent innovative drug delivery systems, as they allow a targeted and prolonged release of poorly water-soluble drugs, improving their bioavailability and modifying their pharmacokinetic parameters. In this work we describe cyclodextrin-based nanosponges, obtained through polimerization of β-cyclodextrin with diphenyl carbonate as the cross-linking agent, loaded with a novel multi-effective heterocyclic compound, DB103, able to regulate key cellular events involved in the remodelling of vessels wall...
April 26, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28452685/interactions-of-giardia-sp-with-the-intestinal-barrier-epithelium-mucus-and-microbiota
#13
Thibault Allain, Christina B Amat, Jean-Paul Motta, Anna Manko, André G Buret
Understanding how intestinal enteropathogens cause acute and chronic alterations has direct animal and human health perspectives. Significant advances have been made on this field by studies focusing on the dynamic crosstalk between the intestinal protozoan parasite model Giardia duodenalis and the host intestinal mucosa. The concept of intestinal barrier function is of the highest importance in the context of many gastrointestinal diseases such as infectious enteritis, inflammatory bowel disease, and post-infectious gastrointestinal disorders...
January 2, 2017: Tissue Barriers
https://www.readbyqxmd.com/read/28443188/intestinal-obstruction-induced-by-peach-stone-in-stenosis-of-sigmoid-colon-by-adenocarcinoma-a-case-report-and-literature-review
#14
Argos Soares de Matos Filho, Clarissa Santos Neto, Andreia Souto da Motta, Isabela de Alencar E Lombardi, Ronielly Araújo Rocha
INTRODUCTION: Intestinal obstruction is the second among the most frequent acute abdominal conditions of the non-traumatic surgical pathologies. It is Found in 20% of patients admitted to the emergency care services with acute abdominal pain. It often results in high morbidity and mortality. PRESENTATION OF CASE: We report a case of a foreign body resulting in a colon obstruction, concomitant with the diagnosis of a sigmoid cancer in a 47-year-old female. DISCUSSION: There are only a few cases of Intestinal Obstruction Induced by Peach Stone in Stenosis of Sigmoid Colon by Adenocarcinoma reported in the world literature...
May 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28435736/crystal-structure-of-1-3-bis-e-benzyl-idene-amino-propan-2-ol
#15
Augusto Rivera, Ingrid Miranda-Carvajal, Jaime Ríos-Motta, Michael Bolte
In the title compound, C17H18N2O, the central carbon atom with the OH substituent and one of the (E)-benzyl-idene-amino substituents are disordered over two sets of sites with occupancies of 0.851 (4) and 0.149 (4). The relative positions of the two disorder components is equivalent to a rotation of approximately 60° about the C-N single bond. In the crystal, the mol-ecules are held together by O-H⋯N hydrogen bonds, forming simple C(5) chains along the b-axis direction. In addition, pairs of the chains are further aggregated by weak C-H⋯π inter-actions...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28434586/the-periaqueductal-gray-and-primal-emotional-processing-critical-to-influence-complex-defensive-responses-fear-learning-and-reward-seeking
#16
REVIEW
Simone C Motta, Antônio P Carobrez, Newton S Canteras
The periaqueductal gray (PAG) has been commonly recognized as a downstream site in neural networks for the expression of a variety of behaviors and is thought to provide stereotyped responses. However, a growing body of evidence suggests that the PAG may exert more complex modulation of a number of behavioral responses and work as a unique hub supplying primal emotional tone to influence prosencephalic sites mediating complex aversive and appetitive responses. Of particular relevance, we review how the PAG is involved in influencing complex forms of defensive responses, such as circa-strike and risk assessment responses in animals...
May 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28432176/a-phase-i-study-of-the-cdk4-6-inhibitor-ribociclib-lee011-in-pediatric-patients-with-malignant-rhabdoid-tumors-neuroblastoma-and-other-solid-tumors
#17
Birgit Geoerger, Franck Bourdeaut, Steven G DuBois, Matthias Fischer, James I Geller, Nicholas G Gottardo, Aurélien Marabelle, Andrew D J Pearson, Shakeel Modak, Thomas Cash, Giles W Robinson, Marlyane Motta, Alessandro Matano, Suraj G Bhansali, Jason R Dobson, Sudha Parasuraman, Susan N Chi
Purpose: The cyclin-dependent kinase (CDK) 4/6 inhibitor, ribociclib (LEE011), displayed preclinical activity in neuroblastoma and malignant rhabdoid tumor (MRT) models. In this phase I study, the maximum tolerated dose (MTD) and recommended phase II dose (RP2D), safety, pharmacokinetics (PK), and preliminary activity of single-agent ribociclib were investigated in pediatric patients with neuroblastoma, MRT, or other cyclin D-CDK4/6-INK4-retinoblastoma pathway-altered tumors.Experimental Design: Patients (aged 1-21 years) received escalating once-daily oral doses of ribociclib (3-weeks-on/1-week-off)...
April 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28423722/the-importance-of-the-genomic-landscape-in-waldenstr%C3%A3-m-s-macroglobulinemia-for-targeted-therapeutical-interventions
#18
REVIEW
Antonio Sacco, Adriano Fenotti, Loredana Affò, Stefano Bazzana, Domenico Russo, Marco Presta, Michele Malagola, Antonella Anastasia, Marina Motta, Christopher J Patterson, Giuseppe Rossi, Luisa Imberti, Steven P Treon, Irene M Ghobrial, Aldo M Roccaro
The Literature has recently reported on the importance of genomics in the field of hematologic malignancies, including B-cell lymphoproliferative disorders such as Waldenström's Macrolgobulinemia (WM). Particularly, whole exome sequencing has led to the identification of the MYD88L265P and CXCR4C1013G somatic variants in WM, occurring in about 90% and 30% of the patients, respectively. Subsequently, functional studies have demonstrated their functional role in supporting WM pathogenesis and disease progression, both in vitro and in vivo, thus providing the pre-clinical evidences for extremely attractive targets for novel therapeutic interventions in WM...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422279/efficacy-and-safety-of-mechanical-thrombectomy-in-older-adults-with-acute-ischemic-stoke
#19
Fabrizio Sallustio, Giacomo Koch, Caterina Motta, Marina Diomedi, Fana Alemseged, Vittoria C D'Agostino, Simone Napolitano, Domenico Samà, Alessandro Davoli, Daniel Konda, Daniele Morosetti, Enrico Pampana, Roberto Floris, Roberto Gandini
OBJECTIVES: To evaluate the safety and efficacy of endovascular therapy in elderly adults treated for acute ischemic stroke. DESIGN: Retrospective cohort study. SETTING: Comprehensive Stroke Center, University of Tor Vergata, Rome, Italy. PARTICIPANTS: Elderly adults treated for acute ischemic stroke (N = 219). MEASUREMENTS: Participants were divided into two groups based on their age (n = 62, ≥80; n = 157, <80)...
April 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28403053/zika-virus-infection-associated-with-congenital-birth-defects-in-a-hiv-infected-pregnant-woman
#20
Esaú Custódio João, Maria Isabel Fragoso da Silveira Gouvea, Maria de Lourdes Benamor Teixeira, Wallace Mendes-Silva, Juliana Silva Esteves, Edwiges Motta Santos, Leandro Augusto Ledesma, Ana Paula Gomes, Maria Letícia Cruz
We describe a case of Zika virus infection acquired during the first trimester in a HIV-infected pregnant woman that led to multiple fetal malformations and fetal demise in Rio de Janeiro, Brazil.
May 2017: Pediatric Infectious Disease Journal
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