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https://www.readbyqxmd.com/read/29331966/effectiveness-and-safety-of-oral-sedation-in-adult-patients-undergoing-dental-procedures-protocol-for-a-systematic-review
#1
Jimmy de Oliveira Araújo, Rogério Heládio Lopes Motta, Cristiane de Cássia Bergamaschi, Caio Chaves Guimarães, Juliana Cama Ramacciato, Natalia Karol de Andrade, Mabel Fernandes Fiqueiró, Luciane Cruz Lopes
INTRODUCTION: The management of anxious patients undergoing dental procedures is still a challenge in clinical practice. Despite a wide variety of drugs for oral sedation in adult patients, there are relatively few systematic reviews that compare the effectiveness and safety of different drugs administered via this route. Thus, this study will evaluate the effectiveness and safety of oral sedation with benzodiazepines and other agents to patients undergoing dental surgical procedures...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331397/persistent-hyperparathyroidism-as-a-risk-factor-for-long-term-graft-failure-the-need-to-discuss-indication-for-parathyroidectomy
#2
Maria Júlia Correia Lima Nepomuceno Araujo, Janaina Almeida Mota Ramalho, Rosilene Motta Elias, Vanda Jorgetti, William Nahas, Melani Custodio, Rosa M A Moysés, Elias David-Neto
BACKGROUND: Although a successful kidney transplant (KTx) improves most of the mineral and bone disorders (MBD) produced by chronic kidney disease (CKD), hyperparathyroidism may persist (pHPT). Current guidelines recommend parathyroidectomy if serum parathormone is persistently elevated 1 year after KTx, because pHPT has been recently associated with poor graft outcomes. However, whether patients with pHPT and adequate renal function are at risk for long-term graft failure is unknown...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29324955/burnout-and-depressive-symptoms-in-intensive-care-nurses-relationship-analysis
#3
Eduardo Motta de Vasconcelos, Milva Maria Figueiredo De Martino, Salomão Patrício de Souza França
OBJECTIVE: To analyze the existence of a relationship between burnout and depressive symptoms among intensive care unit nursing staff. METHOD: A quantitative, descriptive, cross-sectional study with 91 intensive care nurses. Data collection used a sociodemographic questionnaire, the Maslach Burnout Inventory - Human Services Survey, and the Beck Depression Inventory - I. The Pearson test verified the correlation between the burnout dimension score and the total score from the Beck Depression Inventory...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29324430/a-prospective-multicenter-study-to-compare-a-disposable-high-fluid-capacity-underpad-to-nonpermeable-disposable-reusable-containment-products-on-incontinence-associated-dermatitis-rates-among-skilled-nursing-facility-residents
#4
Glenda Motta, Catherine T Milne
Due to the high prevalence of incontinence among skilled nursing facility (SNF) residents, incontinence-associated derma- titis (IAD) is a common occurrence. In addition, facility staff may mistakenly identify IAD as a pressure injury. A prospective, descriptive, multicenter study was conducted in 3 Connecticut facilities to evaluate the effect of substituting a disposable, high- uid capacity underpad for nonpermeable disposable and reusable containment products on the rate of IADs. Residents with and without IAD but with high IAD risk scores who were bed- or chairbound or ambulatory and used disposable nonpermeable briefs and underpads or reusable, laundered containment products when in bed longer than 2 hours were randomly enrolled and observed for a 4-week period...
December 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/29319724/evaluation-of-the-efficacy-and-safety-of-endovascular-management-for-transplant-renal-artery-stenosis
#5
Leonardo G M Valle, Rafael N Cavalcante, Joaquim M Motta-Leal-Filho, Breno B Affonso, Francisco L Galastri, Marisa P Doher, Nadia K Guimarães-Souza, Ana K N Cavalcanti, Rodrigo G Garcia, Álvaro Pacheco-Silva, Felipe Nasser
OBJECTIVES: To evaluate the safety and efficacy of endovascular intervention with angioplasty and stent placement in patients with transplant renal artery stenosis. METHODS: All patients diagnosed with transplant renal artery stenosis and graft dysfunction or resistant systemic hypertension who underwent endovascular treatment with stenting from February 2011 to April 2016 were included in this study. The primary endpoint was clinical success, and the secondary endpoints were technical success, complication rate and stent patency...
December 2017: Clinics
https://www.readbyqxmd.com/read/29318136/pleural-tuberculosis-medical-thoracoscopy-greatly-increases-the-diagnostic-accuracy
#6
Angelo Gianni Casalini, Pier Anselmo Mori, Maria Majori, Miriam Anghinolfi, Enrico Maria Silini, Letizia Gnetti, Federica Motta, Sandra Larini, Sara Montecchini, Roberta Pisi, Adriana Calderaro
Our objective was to evaluate the efficacy of a standardised work-up in the diagnosis of pleural tuberculosis (TB) that included fibreoptic bronchoscopy and medical thoracoscopy. A consecutive series of 52 pleural TB patients observed during the period 2001-2015 was evaluated retrospectively. 20 females, mean (range) age 39.7 (18-74) years, and 32 males, mean (range) age 45.75 (21-83) years, were included (28 non-EU citizens (53.8%)). The diagnosis of TB infections was established by identification (using stains, culture or molecular tests) of Mycobacterium tuberculosis in the pleura, sputum and/or bronchial specimens, or by evidence of caseous granulomas on pleural biopsies...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29306702/changes-in-mouse-gut-bacterial-community-in-response-to-different-types-of-drinking-water
#7
Marcela F Dias, Mariana P Reis, Leonardo B Acurcio, Anderson O Carmo, Cristiane F Diamantino, Amanda M Motta, Evanguedes Kalapothakis, Jacques R Nicoli, Andréa M A Nascimento
Gut microbiota exerts a fundamental role on host physiology, and how extrinsic perturbations influence its composition has been increasingly examined. However, the effect of drinking water on gut microbiota is still poorly understood. In this study, we explored the response of mouse gut bacterial community (fecal and mucosa-adhered) to the ingestion of different types of drinking water. The experimental cohort was divided according to different water sources into four groups of mice that consumed autoclaved tap water (control group), water collected directly from a drinking water treatment plant, tap water, and commercial bottled mineral water...
December 29, 2017: Water Research
https://www.readbyqxmd.com/read/29304398/generation-of-human-induced-pluripotent-stem-cells-euraci001-a-euraci002-a-euraci003-a-from-peripheral-blood-mononuclear-cells-of-three-patients-carrying-mutations-in-the-cav3-gene
#8
Viviana Meraviglia, Patrizia Benzoni, Sara Landi, Carmen Murano, Marianna Langione, Benedetta M Motta, Serena Baratto, Rosamaria Silipigni, Marina Di Segni, Peter P Pramstaller, Dario DiFrancesco, Elisabetta Gazzerro, Andrea Barbuti, Alessandra Rossini
Caveolinopathies are a heterogeneous family of genetic pathologies arising from alterations of the caveolin-3 gene (CAV3), encoding for the isoform specifically constituting muscle caveolae. Here, by reprogramming peripheral blood mononuclear cells, we report the generation of induced pluripotent stem cells (iPSCs) from three patients carrying the ΔYTT deletion, T78K and W101C missense mutations in caveolin-3. iPSCs displayed normal karyotypes and all the features of pluripotent stem cells in terms of morphology, specific marker expression and ability to differentiate in vitro into the three germ layers...
December 18, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29302290/pigmented-squamous-cell-carcinoma-in-situ-report-of-a-new-case-and-review-of-the-literature
#9
Fabiana Martins, Florence-Zumbaio Mistro, Sergio Kignel, Michelle Palmieri, Alan-Motta do Canto, Paulo-Henrique Braz-Silva
Pigmented squamous cell carcinoma in situ (PSCCIS) is very rare, being clinically described as a pigmented lesion with histological characteristics of an in-situ carcinoma presenting pigmentation within neoplastic cells. A 50-year-old Afro-descendant man came for clinical evaluation of a painful black and red lesion located on the right aspect of the oropharyngeal isthmus. After incisional biopsy, the resulting sample was described as a pigmented squamous cell carcinoma in situ, a diagnosis further confirmed by immunohistochemical analysis...
November 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29297760/silk-fibroin-porous-scaffolds-by-n2o-foaming
#10
Devid Maniglio, Walter Bonani, Claudio Migliaresi, Antonella Motta
Silk fibroin has acquired increasing interest for biomedical applications, and namely for the fabrication of scaffolds for tissue engineering, because of its highly positive biological interaction and the possibility to adapt the material to several application requirements by adopting different fabrication methods, in order to make films, sponges, fibers, nets or gels with predictable degradation times. For tissue engineering, in most cases porous scaffolds are required, in some cases possibly in situ forming and therefore fabricated in mild body-compatible conditions...
January 3, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29297564/oral-nodular-lesions-in-patients-with-sj%C3%A3-gren-s-syndrome-unusual-oral-implications-of-a-systemic-disorder
#11
Juliana Barchelli Pinheiro, Camila Tirapelli, Claudia Helena Lovato da Silva, Marilena Chinali Komesu, Flávio Calil Petean, Paulo Louzada Junior, Jorge Esquiche León, Ana Carolina Fragoso Motta
Sjögren's syndrome (SS) is a systemic chronic autoimmune disorder affecting the lacrimal and salivary glands. SS may manifest as primary SS (pSS) or secondary SS (sSS), the latter occurring in the context of another autoimmune disorder. In both cases, the dry eyes and mouth affect the patient's quality of life. Late complications may include blindness, dental tissue destruction, oral candidiasis and lymphoma. This paper reports two cases of SS, each of them presenting unusual oral nodular lesion diagnosed as relapsed MALT lymphoma and mucocele...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29291434/short-term-particulate-matter-exposure-influences-nasal-microbiota-in-a-population-of-healthy-subjects
#12
Jacopo Mariani, Chiara Favero, Andrea Spinazzè, Domenico Maria Cavallo, Michele Carugno, Valeria Motta, Matteo Bonzini, Andrea Cattaneo, Angela Cecilia Pesatori, Valentina Bollati
BACKGROUND: Exposure to air pollutants, such as particulate matter (PM), represents a growing health problem. The aim of our study was to investigate whether PM could induce a dysbiosis in the nasal microbiota in terms of α-diversity and taxonomic composition. METHODS: We investigated structure and characteristics of the microbiota of 40 healthy subjects through metabarcoding analysis of the V3-V4 regions of the 16s rRNA gene. Exposure to PM10 and PM2.5 was assessed with a personal sampler worn for 24h before sample collection (Day -1) and with measurements from monitoring stations (from Day -2 to Day -7)...
December 28, 2017: Environmental Research
https://www.readbyqxmd.com/read/29288089/exploring-the-molecular-complexity-of-triatoma-dimidiata-sialome
#13
Paula Beatriz Santiago, Carla Nunes de Araújo, Sébastien Charneau, Izabela Marques Dourado Bastos, Teresa Cristina F Assumpção, Rayner Myr Lauterjung Queiroz, Yanna Reis Praça, Thuany de Moura Cordeiro, Carlos Henrique Saraiva Garcia, Ionizete Garcia da Silva, Tainá Raiol, Flávia Nader Motta, João Victor de Araújo Oliveira, Marcelo Valle de Sousa, José Marcos C Ribeiro, Jaime Martins de Santana
Triatoma dimidiata, a Chagas disease vector widely distributed along Central America, has great capability for domestic adaptation as the majority of specimens caught inside human dwellings or in peridomestic areas fed human blood. Exploring the salivary compounds that overcome host haemostatic and immune responses is of great scientific interest. Here, we provide a deeper insight into its salivary gland molecules. We used high-throughput RNA sequencing to examine in depth the T. dimidiata salivary gland transcriptome...
December 26, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29282091/gender-differences-in-patterns-of-drug-use-and-sexual-risky-behaviour-among-crack-cocaine-users-in-central-brazil
#14
Rafael Alves Guimarães, Vivianne de Oliveira Landgraf de Castro, Sandra Maria do Valle Leone de Oliveira, Andréa Cristina Stabile, Ana Rita Coimbra Motta-Castro, Megmar Aparecida Dos Santos Carneiro, Lyriane Apolinário Araujo, Karlla Antonieta Amorim Caetano, Marcos André de Matos, Sheila Araujo Teles
BACKGROUND: The aim of this study was to compare sociodemographic characteristics, patterns of drug use, and risky sexual behaviour among female and male users of crack cocaine. METHODS: Between 2012 and 2013, we conducted a cross-sectional study of 919 crack cocaine users (783 men and 136 women) in Central Brazil using face-to-face interviews. Blood samples were collected to test for syphilis. The Chi-Square Automatic Interaction Detector (CHAID) was used to explore the differences between genders...
December 28, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29279371/enhancement-of-hepatic-autophagy-increases-ureagenesis-and-protects-against-hyperammonemia
#15
Leandro R Soria, Gabriella Allegri, Dominique Melck, Nunzia Pastore, Patrizia Annunziata, Debora Paris, Elena Polishchuk, Edoardo Nusco, Beat Thöny, Andrea Motta, Johannes Häberle, Andrea Ballabio, Nicola Brunetti-Pierri
Ammonia is a potent neurotoxin that is detoxified mainly by the urea cycle in the liver. Hyperammonemia is a common complication of a wide variety of both inherited and acquired liver diseases. If not treated early and thoroughly, it results in encephalopathy and death. Here, we found that hepatic autophagy is critically involved in systemic ammonia homeostasis by providing key urea-cycle intermediates and ATP. Hepatic autophagy is triggered in vivo by hyperammonemia through an α-ketoglutarate-dependent inhibition of the mammalian target of rapamycin complex 1, and deficiency of autophagy impairs ammonia detoxification...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29277405/transcranial-magnetic-stimulation-of-the-precuneus-enhances-memory-and-neural-activity-in-prodromal-alzheimer-s-disease
#16
Giacomo Koch, Sonia Bonnì, Maria Concetta Pellicciari, Elias P Casula, Matteo Mancini, Romina Esposito, Viviana Ponzo, Silvia Picazio, Francesco Di Lorenzo, Laura Serra, Caterina Motta, Michele Maiella, Camillo Marra, Mara Cercignani, Alessandro Martorana, Carlo Caltagirone, Marco Bozzali
Memory loss is one of the first symptoms of typical Alzheimer's disease (AD), for which there are no effective therapies available. The precuneus (PC) has been recently emphasized as a key area for the memory impairment observed in early AD, likely due to disconnection mechanisms within large-scale networks such as the default mode network (DMN). Using a multimodal approach we investigated in a two-week, randomized, sham-controlled, double-blinded trial the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the PC on cognition, as measured by the Alzheimer Disease Cooperative Study Preclinical Alzheimer Cognitive Composite in 14 patients with early AD (7 females)...
December 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/29273518/d2a-ala-peptide-derived-from-the-urokinase-receptor-exerts-anti-tumoural-effects-in-vitro-and-in-vivo
#17
Federico Furlan, Gabriele Eden, Marco Archinti, Ralitsa Arnaudova, Giuseppina Andreotti, Valentina Citro, Maria Vittoria Cubellis, Andrea Motta, Bernard Degryse
D2A-Ala is a synthetic peptide that has been created by introducing mutations in the original D2A sequence, 130IQEGEEGRPKDDR142 of human urokinase receptor (uPAR). In vitro, D2A-Ala peptide displays strong anti-tumoural properties inhibiting EGF-induced chemotaxis, invasion and proliferation of a human fibrosarcoma cell line, HT 1080, and a human colorectal adenocarcinoma cell line, HT 29. D2A-Ala exerts its effects by preventing EGF receptor (EGFR) phosphorylation. To test D2A-Ala in vivo, this peptide was PEGylated generating polyethyleneglycol (PEG)-D2A-Ala peptide...
December 19, 2017: Peptides
https://www.readbyqxmd.com/read/29259064/bleeding-risk-in-patients-using-oral-anticoagulants-submitted-to-surgical-procedures-in-dentistry-a-systematic-review-protocol
#18
Rogério Heládio Lopes Motta, Cristiane de Cássia Bergamaschi, Natalia Karol de Andrade, Caio Chaves Guimaraes, Juliana Cama Ramacciato, Jimmy de Oliveira Araújo, Luciane Cruz Lopes
INTRODUCTION: The management of patients undergoing oral surgical procedures using anticoagulants raises concerns regarding the risk of bleeding. Bleeding rates in those patients during or after oral surgical procedures are uncertain. The aim of this study will be to determine the bleeding rate during and after oral surgeries in patients using anticoagulants. METHODS AND ANALYSIS: A systematic review will be conducted and if appropriate, a meta-analysis of randomised clinical trials evaluating the bleeding risk during and after oral surgical procedures in patients using anticoagulants were selected...
December 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29247431/infrared-photobiomodulation-pbm-therapy-improves-glucose-metabolism-and-intracellular-insulin-pathway-in-adipose-tissue-of-high-fat-fed-mice
#19
Gabriela Silva, Cleber Ferraresi, Rodrigo Teixeira de Almeida, Mariana Lopes Motta, Thiago Paixão, Vinicius Oliveira Ottone, Ivana Alice Fonseca, Murilo Xavier Oliveira, Etel Rocha-Vieira, Marco Fabrício Dias-Peixoto, Elizabethe Adriana Esteves, Cândido Celso Coimbra, Fabiano Trigueiro Amorim, Flávio de Castro Magalhães
Obesity represents a continuously growing global epidemic and is associated with the development of type 2 diabetes mellitus. The etiology of type 2 diabetes is related to the resistance of insulin-sensitive tissues to its action leading to impaired blood glucose regulation. Photobiomodulation (PBM) therapy might be a non-pharmacological, non-invasive strategy to improve insulin resistance. It has been reported that PBM therapy in combination with physical exercise reduces insulin resistance. Therefore, the aim of this study was to investigate the effects of PBM therapy on insulin resistance in obese mice...
December 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29239460/guidelines-for-the-treatment-of-lung-cancer-using-radiotherapy
#20
Michael J Chen, Paulo Eduardo Novaes, Rafael Gadia, Rodrigo Motta
No abstract text is available yet for this article.
September 2017: Revista da Associação Médica Brasileira
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