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https://www.readbyqxmd.com/read/28099157/high-quality-epitaxial-graphene-by-hydrogen-etching-of-3c-sic-111-thin-film-on-si-111
#1
Bharati Gupta, Carlo Mariani, Josh Lipton-Duffin, Nunzio Motta, Pierluigi Mondelli, Maria Betti
Etching with atomic hydrogen as a preparation step before the high-temperature growth process of graphene onto a thin 3C-SiC film grown on Si(111) greatly improves the structural quality of topmost graphene layers. Pit formation and island coalescence, which are typical of graphene growth by SiC graphitization, are quenched and accompanied by widening of the graphene domain sizes to hundreds of nm, and by a significant reduction in surface roughness down to a single substrate bilayer. The surface reconstructions expected for graphene and the underlying layer are shown with atomic resolution by scanning tunnelling microscopy (STM)...
January 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28096305/epithelial-expression-and-function-of-trypsin-3-in-irritable-bowel-syndrome
#2
Claire Rolland-Fourcade, Alexandre Denadai-Souza, Carla Cirillo, Cintya Lopez, Josue Obed Jaramillo, Cleo Desormeaux, Nicolas Cenac, Jean-Paul Motta, Muriel Larauche, Yvette Taché, Pieter Vanden Berghe, Michel Neunlist, Emmanuel Coron, Sylvain Kirzin, Guillaume Portier, Delphine Bonnet, Laurent Alric, Stephen Vanner, Celine Deraison, Nathalie Vergnolle
OBJECTIVES: Proteases are key mediators of pain and altered enteric neuronal signalling, although the types and sources of these important intestinal mediators are unknown. We hypothesised that intestinal epithelium is a major source of trypsin-like activity in patients with IBS and this activity signals to primary afferent and enteric nerves and induces visceral hypersensitivity. DESIGN: Trypsin-like activity was determined in tissues from patients with IBS and in supernatants of Caco-2 cells stimulated or not...
January 17, 2017: Gut
https://www.readbyqxmd.com/read/28095140/prom1-gene-variations-in-brazilian-patients-with-macular-dystrophy
#3
Mariana Vallim Salles, Fabiana Louise Motta, Elton Dias da Silva, Patricia Varela Lima Teixeira, Kárita Antunes Costa, Rafael Filippelli-Silva, Renan Martin, João Bosco Pesquero, Juliana Maria Ferraz Sallum
BACKGROUND: Although the pathogenicity of the prominin-1 (PROM1) gene has already been described as associated with autosomal dominant Stargardt disease, little is known about sequence variations in this gene. PURPOSE: The aim of this study was to evaluate PROM1 gene sequence variations in patients with macular dystrophy. MATERIAL AND METHODS: This retrospective study evaluated variations in the PROM1 gene detected by next-generation sequencing test in patients with macular dystrophy and Stargardt disease...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28093132/controlled-release-oxycodone-improves-pain-management-after-uterine-artery-embolisation-for-symptomatic-fibroids
#4
G M G Freire, R N Cavalcante, J M Motta-Leal-Filho, M Messina, F L Galastri, B B Affonso, R D Rocha, F Nasser
AIM: To evaluate if pre- and post-procedure administration of controlled-release oxycodone (CRO) in combination with standard analgesia improves pain control and decreases the amount of required post-procedure opioids in uterine fibroid embolisation (UFE). MATERIALS AND METHODS: Between January 2009 and March 2010, 60 consecutive women were prospectively randomised in two groups for UFE: the control group, in which 30 patients underwent the standard anaesthetic procedure and the CRO group, in which 30 patients underwent the standard anaesthetic procedure with the addition of CRO...
January 13, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28069073/quantification-of-postural-stability-in-minimally-disabled-multiple-sclerosis-patients-by-means-of-dynamic-posturography-an-observational-study
#5
Lucia Grassi, Stefano Rossi, Valeria Studer, Gessica Vasco, Caterina Motta, Fabrizio Patanè, Enrico Castelli, Silvia Rossi, Paolo Cappa
BACKGROUND: Multiple Sclerosis (MS) is a widespread progressive neurologic disease with consequent impairments in daily activities. Disorders of balance are frequent and equilibrium tests are potentially useful to quantify disability and to verify treatment effectiveness. The fair sensitivity of the widely used not-perturbed tests to detect balance disturbances in MS patients have prompted the development of mechatronic systems capable to impose known equilibrium perturbations, in order to challenge the balance control and, consequently, to better assess the level of impairment...
January 10, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28067900/donor-cd19-car-t-cells-exert-potent-graft-versus-lymphoma-activity-with-diminished-graft-versus-host-activity
#6
Arnab Ghosh, Melody Smith, Scott E James, Marco L Davila, Enrico Velardi, Kimon V Argyropoulos, Gertrude Gunset, Fabiana Perna, Fabiana M Kreines, Emily R Levy, Sophie Lieberman, Hillary V Jay, Andrea Z Tuckett, Johannes L Zakrzewski, Lisa Tan, Lauren F Young, Kate Takvorian, Jarrod A Dudakov, Robert R Jenq, Alan M Hanash, Ana Carolina F Motta, George F Murphy, Chen Liu, Andrea Schietinger, Michel Sadelain, Marcel R M van den Brink
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT. Chimeric antigen receptors (CARs) direct tumor cell recognition of adoptively transferred T cells. CD19 is an attractive CAR target, which is expressed in most B cell malignancies, as well as in healthy B cells. Clinical trials using autologous CD19-targeted T cells have shown remarkable promise in various B cell malignancies...
January 9, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28063689/associations-of-linear-growth-and-relative-weight-gain-in-early-life-with-human-capital-at-30-years-of-age
#7
Bernardo Lessa Horta, Cesar G Victora, Christian Loret de Mola, Luciana Quevedo, Ricardo Tavares Pinheiro, Denise P Gigante, Janaina Vieira Dos Santos Motta, Fernando C Barros
OBJECTIVE: To assess the associations of birthweight, nutritional status and growth in childhood with IQ, years of schooling, and monthly income at 30 years of age. STUDY DESIGN: In 1982, the 5 maternity hospitals in Pelotas, Brazil, were visited daily and 5914 live births were identified. At 30 years of age, 3701 subjects were interviewed. IQ, years of schooling, and income were measured. RESULTS: On average, their IQ was 98 points, they had 11...
January 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28060860/prevalence-and-incidence-of-hcv-infection-among-prisoners-in-central-brazil
#8
Marco Antonio Moreira Puga, Larissa Melo Bandeira, Mauricio Antonio Pompilio, Julio Croda, Grazielli Rocha de Rezende, Luiz Fernando Paiva Dorisbor, Tayana Serpa Ortiz Tanaka, Gabriela Alves Cesar, Sheila Araújo Teles, Simone Simionatto, Alisson Richard Teixeira Novais, Bruna Nepomuceno, Lisie Souza Castro, Barbara Vieira do Lago, Ana Rita Coimbra Motta-Castro
The aim of this multicenter, cross sectional study was to assess the prevalence, incidence and associated risk factors among incarcerated populations from twelve Brazilian prisons. The total of 3,368 individuals from twelve prisons was randomly recruited between March 2013 and March 2014. Participants were interviewed, and provided blood samples which were tested for antibodies to Hepatitis C (HCV ab). One year after the first investigation, a cohort study was conducted with 1,656 inmates who participated the cross sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28032175/patient-versus-surgeon-preferences-between-traditional-and-neo-omphaloplasty-in-post-bariatric-abdominoplasty
#9
Maria Gabriela Bonilha Vallim, Davi Reis Calderoni, Marco Antonio Camargo Bueno, Marcos Matias Motta, Rafael de Campos Ferreira Basso, Paulo Kharmandayan
BACKGROUND: Abdominoplasty procedures have been proven highly valuable in promoting better quality of life for post-bariatric surgery patients. The literature reveals that the aspect of the navel is one of the most problematic issues regarding surgical results and many different surgical techniques have been proposed to obtain a satisfactory outcome. However, little is known about patients' preferences regarding these different techniques and their results. The aim of the present study was to compare evaluations made by plastic surgeons and patients of the results of two different techniques-traditional omphaloplasty and neo-omphaloplasty with lateral flaps...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28017658/vitamin-c-and-l-proline-antagonistic-effects-capture-alternative-states-in-the-pluripotency-continuum
#10
Cristina D'Aniello, Ehsan Habibi, Federica Cermola, Debora Paris, Francesco Russo, Alessandro Fiorenzano, Gabriele Di Napoli, Dominique J Melck, Gilda Cobellis, Claudia Angelini, Annalisa Fico, Robert Blelloch, Andrea Motta, Hendrik G Stunnenberg, Dario De Cesare, Eduardo J Patriarca, Gabriella Minchiotti
Metabolites and cofactors are emerging as key regulators of cell plasticity and reprogramming, and their role in the control of pluripotency is just being discovered. Here we provide unprecedented evidence that embryonic stem cell (ESC) pluripotency relies on the relative levels of two physiological metabolites, namely ascorbic acid (vitamin C, VitC) and l-proline (l-Pro), which affect global DNA methylation, transcriptional profile, and energy metabolism. Specifically, while a high VitC/l-Pro ratio drives ESCs toward a naive state, the opposite condition (l-Pro excess) captures a fully reversible early primed pluripotent state, which depends on autocrine fibroblast growth factor and transforming growth factor β signaling pathways...
January 10, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28011755/computational-modeling-of-brain-pathologies-the-case-of-multiple-sclerosis
#11
Francesco Pappalardo, Abdul-Mateen Rajput, Santo Motta
The central nervous system is the most complex network of the human body. The existence and functionality of a large number of molecular species in human brain are still ambiguous and mostly unknown, thus posing a challenge to Science and Medicine. Neurological diseases inherit the same level of complexity, making effective treatments difficult to be found. Multiple sclerosis (MS) is a major neurological disease that causes severe inabilities and also a significant social burden on health care system: between 2 and 2...
December 22, 2016: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28006815/a-new-species-of-i-moenkhausia-i-eigenmann-1903-characiformes-characidae-from-amazon-basin-brazil
#12
Isabel Matos Soares, Cristina Motta Bührnheim
A new species of Moenkhausia is described from tributaries of the lower Amazon basin, Pará State, Brazil. The new species is morphologically similar to Moenkhausia collettii, M. copei, and M. venerei by the presence of a dark horizontal stripe across the middle portion of the eye, a conspicuous slightly rounded humeral blotch, a dark longitudinal midlateral stripe and a dark stripe along the anal-fin base. However, the new species can be distinguished from M. collettii, M. copei, and M. venerei mainly by the number of cusps on the inner row of the premaxillary, maxillary and dentary teeth, and by the number of scales in transversal series above and below the lateral line...
December 18, 2016: Zootaxa
https://www.readbyqxmd.com/read/28003785/central-retinal-vein-occlusion-associated-with-high-blood-levels-of-lipoprotein-a-is-lipoprotein-a-a-reliable-marker-for-identification-of-predisposed-individuals
#13
Piergiacomo Grassi, Alberto Salicone, Lorenzo Motta, Mario Salvatore Motta
To report a case of central retinal vein occlusion (CRVO) associated with abnormal elevation of Lipoprotein (a) [Lp(a)] plasma levels, without local or systemic risk factors. A 74-year-old man was referred to our department for cataract surgery in his left eye, and his anamnesis was negative for systemic diseases. Two months later, the patient presented with sudden visual loss in his operated eye, and comprehensive ophthalmic examination was performed, including Fluorescein Angiography (FA) and Optical Coherent Tomography (OCT)...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28002404/epigenome-wide-association-study-of-body-mass-index-and-the-adverse-outcomes-of-adiposity
#14
Simone Wahl, Alexander Drong, Benjamin Lehne, Marie Loh, William R Scott, Sonja Kunze, Pei-Chien Tsai, Janina S Ried, Weihua Zhang, Youwen Yang, Sili Tan, Giovanni Fiorito, Lude Franke, Simonetta Guarrera, Silva Kasela, Jennifer Kriebel, Rebecca C Richmond, Marco Adamo, Uzma Afzal, Mika Ala-Korpela, Benedetta Albetti, Ole Ammerpohl, Jane F Apperley, Marian Beekman, Pier Alberto Bertazzi, S Lucas Black, Christine Blancher, Marc-Jan Bonder, Mario Brosch, Maren Carstensen-Kirberg, Anton J M de Craen, Simon de Lusignan, Abbas Dehghan, Mohamed Elkalaawy, Krista Fischer, Oscar H Franco, Tom R Gaunt, Jochen Hampe, Majid Hashemi, Aaron Isaacs, Andrew Jenkinson, Sujeet Jha, Norihiro Kato, Vittorio Krogh, Michael Laffan, Christa Meisinger, Thomas Meitinger, Zuan Yu Mok, Valeria Motta, Hong Kiat Ng, Zacharoula Nikolakopoulou, Georgios Nteliopoulos, Salvatore Panico, Natalia Pervjakova, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Federica Rota, Michelle Ann Rozario, Johanna K Sandling, Clemens Schafmayer, Katharina Schramm, Reiner Siebert, P Eline Slagboom, Pasi Soininen, Lisette Stolk, Konstantin Strauch, E-Shyong Tai, Letizia Tarantini, Barbara Thorand, Ettje F Tigchelaar, Rosario Tumino, Andre G Uitterlinden, Cornelia van Duijn, Joyce B J van Meurs, Paolo Vineis, Ananda Rajitha Wickremasinghe, Cisca Wijmenga, Tsun-Po Yang, Wei Yuan, Alexandra Zhernakova, Rachel L Batterham, George Davey Smith, Panos Deloukas, Bastiaan T Heijmans, Christian Herder, Albert Hofman, Cecilia M Lindgren, Lili Milani, Pim van der Harst, Annette Peters, Thomas Illig, Caroline L Relton, Melanie Waldenberger, Marjo-Riitta Järvelin, Valentina Bollati, Richie Soong, Tim D Spector, James Scott, Mark I McCarthy, Paul Elliott, Jordana T Bell, Giuseppe Matullo, Christian Gieger, Jaspal S Kooner, Harald Grallert, John C Chambers
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype. Here we use epigenome-wide association to show that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 × 10(-7), range P = 9...
December 21, 2016: Nature
https://www.readbyqxmd.com/read/27999742/reprogramming-of-tlr7-signaling-enhances-antitumor-nk-and-cytotoxic-t-cell-responses
#15
Christian Hotz, Marina Treinies, Ines Mottas, Laurin C Rötzer, Anne Oberson, Lorenzo Spagnuolo, Maurizio Perdicchio, Thibaud Spinetti, Tina Herbst, Carole Bourquin
Toll-like receptor (TLR) 7 agonists are effective in topical application for the immunotherapy of skin cancers, but their performance for the systemic treatment of solid tumors is limited by the development of TLR tolerance. In this study, we describe a novel strategy to overcome TLR tolerance and enhance TLR7-dependent antitumor immune responses through reprogramming of TLR signaling pathways. The sensitivity of TLR7 signaling in dendritic cells (DC) was increased by prior stimulation with the dsRNA poly(I:C) that mimics virally induced immune activation...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27999739/tlr7-based-cancer-immunotherapy-decreases-intratumoral-myeloid-derived-suppressor-cells-and-blocks-their-immunosuppressive-function
#16
Thibaud Spinetti, Lorenzo Spagnuolo, Inès Mottas, Chiara Secondini, Marina Treinies, Curzio Rüegg, Christian Hotz, Carole Bourquin
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with the capacity to inhibit immunological responses. During cancer progression, MDSC are recruited to the tumor sites and secondary lymphoid organs, leading to the suppression of the antitumor function of NK and T cells. Here, we show that the TLR7/8 agonist resiquimod (R848) has a direct effect on MDSC populations in tumor-bearing mice. Systemic application of R848 led to a rapid reduction in both intratumoral and circulating MDSC...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27997515/zika-virus-infection-associated-with-congenital-birth-defects-in-a-hiv-infected-pregnant-woman
#17
Esaú Custódio João, Maria Isabel Fragoso da Silveira Gouvea, Maria de Lourdes Benamor Teixeira, Wallace Mendes-Silva, Juliana Silva Esteves, Edwiges Motta Santos, Leandro Augusto Ledesma, Maria Letícia Cruz
We describe a case of Zika Virus infection acquired during the first trimester in a HIV-infected pregnant woman that led to multiple fetal malformations and fetal demise in Rio de Janeiro, Brazil.
December 15, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27995903/experimental-study-of-laminar-and-turbulent-boundary-layer-separation-control-of-shark-skin
#18
Farhana Afroz, Amy Lang, Maria Laura Habegger, Philip Motta, Robert Hueter
The Shortfin Mako shark (Isurus oxyrinchus) is a fast swimmer and has incredible turning agility, and has flexible scales known to bristle up to 50° in the flank regions. It is purported that this bristling capability of the scales may result in a unique pass flow control method to control flow separation and reduce drag. It appears that the scales have evolved to be only actuated when the flow over the body is reversed; thereby inducing a method of inhibiting flow reversal close to the surface. In addition, bristled scales form cavities which could induce boundary layer mixing and further assist in delaying flow separation...
December 20, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27993986/tael-a-zebrafish-optimized-optogenetic-gene-expression-system-with-fine-spatial-and-temporal-control
#19
Anna Reade, Laura B Motta-Mena, Kevin H Gardner, Didier Y Stainier, Orion D Weiner, Stephanie Woo
Here, we describe an optogenetic gene expression system optimized for use in zebrafish. This system overcomes the limitations of current inducible expression systems by enabling robust spatial and temporal regulation of gene expression in living organisms. Because existing optogenetic systems show toxicity in zebrafish, we re-engineered the blue-light-activated EL222 system for minimal toxicity while exhibiting a large range of induction, fine spatial precision and rapid kinetics. We validate several strategies to spatially restrict illumination and thus gene induction with our new TAEL (TA4-EL222) system...
January 15, 2017: Development
https://www.readbyqxmd.com/read/27992030/perceptions-of-adolescents-family-members-about-therapeutic-workshops-in-a-child-psychosocial-care-center
#20
Arlete Aparecida Noronha, Daniela Folle, Andréa Noeremberg Guimarães, Maria Luiza Bevilaqua Brum, Jacó Fernando Schneider, Maria da Graça Corso da Motta
Objective: To learn the perceptions of adolescents' family members about therapeutic workshops in a Child Psychosocial Care Center (CAPSi). Methods: A qualitative, descriptive study conducted in 2013 in Santa Catarina, comprising 18 family members of adolescents being cared for in a CAPSi. Information was gathered through interviews construed based on content analysis. Results: Two themes were identified: (un)awareness about therapeutic workshops and recognition of therapy workshops...
December 15, 2016: Revista Gaúcha de Enfermagem
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