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https://www.readbyqxmd.com/read/28641277/association-of-the-cfh-y402h-polymorphism-with-the-1-year-response-of-exudative-amd-to-intravitreal-anti-vegf-treatment-in-the-brazilian-population
#1
Flavio Mac Cord Medina, Augusto Alves Lopes da Motta, Walter Yukihiko Takahashi, Pedro Carlos Carricondo, Mario Martins Dos Santos Motta, Monica B Melo, Jose Paulo C Vasconcellos
AIM: Evidence of the relationship between the polymorphism of the complement factor H (CFH) gene at position 402 (Y402H) and the response to the treatment of wet AMD is controversial. The aim of this study was to compare the functional and morphological 1-year evolution of patients with exudative AMD treated with antivascular endothelial growth factor (VEGF) drugs with the CFH Y402H polymorphism in the Brazilian population. METHODS: Forty-six patients treated for wet AMD with bevacizumab or ranibizumab in a pro re nata regimen were included...
June 23, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28640664/%C3%A2-somos-iguales-using-a-structural-violence-framework-to-understand-gender-and-health-inequities-from-an-intersectional-perspective-in-the-peruvian-amazon
#2
Geordan D Shannon, Angelica Motta, Carlos F Cáceres, Jolene Skordis-Worrall, Diana Bowie, Audrey Prost
BACKGROUND: In the Peruvian Amazon, historical events of colonization and political marginalization intersect with identities of ethnicity, class and geography in the construction of gender and health inequities. Gender-based inequalities can manifest in poor health outcomes via discriminatory practices, healthcare system imbalances, inequities in health research, and differential exposures and vulnerabilities to diseases. Structural violence is a comprehensive framework to explain the mechanisms by which social forces such as poverty, racism and gender inequity become embodied as individual experiences and health outcomes, and thus may be a useful tool in structuring an intersectional analysis of gender and health inequities in Amazonian Peru...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28638638/crystal-structure-of-2-2-ethane-1-2-di-yl-bis-2-3-di-hydro-1h-naphtho-1-2-e-1-3-oxazine-a-prospective-raw-material-for-polybenzoxazines
#3
Augusto Rivera, Juan E Cepeda-Santamaría, Jaime Ríos-Motta, Michael Bolte
In the title compound, C26H24N2O2, the oxazine moiety is fused to a naphthalene ring system. The asymmetric unit consists of one half of the mol-ecule, which lies about an inversion centre. The C atoms of the ethyl-ene spacer group adopt an anti-periplanar arrangement. The oxazine ring adopts a half-chair conformation. In the crystal, supra-molecular chains running along the b axis are formed via short C-H⋯π contacts. The crystal studied was a non-merohedral twin with a fractional contribution of 0.168 (2) of the minor twin component...
June 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28638633/1-3-bis-e-4-di-methyl-amino-benzyl-idene-amino-propan-2-ol-chain-structure-formation-via-an-o-h%C3%A2-n-hydrogen-bond
#4
Augusto Rivera, Ingrid Miranda-Carvajal, Jaime Ríos-Motta, Michael Bolte
The asymmetric unit of the title compound, C21H28N4O, consists of two unique mol-ecules linked by an O-H⋯N hydrogen bond. The conformation of both C=N bonds is E and the azomethine functional groups lie close to the plane of their associated benzene rings in each of the independent mol-ecules. The dihedral angles between the two benzene rings are 83.14 (4) and 75.45 (4)°. The plane of the one of the N(CH3)2 units is twisted away from the benzene ring by 18.8 (2)°, indicating loss of conjugation between the lone electron pair and the benzene ring...
June 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28635138/snake-spectacle-vessel-permeability-to-sodium-fluorescein
#5
Roy W Bellhorn, Ann R Strom, Monica J Motta, John Doval, Michelle G Hawkins, Joanne Paul-Murphy
OBJECTIVE: Assess vascular permeability of the snake spectacle to sodium fluorescein during resting and shedding phases of the ecdysis cycle. ANIMAL STUDIED: Ball python (Python regius). PROCEDURES: The snake was anesthetized, and spectral domain optic coherence tomography was performed prior to angiographic procedures. An electronically controlled digital single-lens reflex camera with a dual-head flash equipped with filters suitable for fluorescein angiography was used to make images...
June 20, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28631320/spatial-patterns-and-broad-scale-weather-cues-of-beech-mast-seeding-in-europe
#6
Giorgio Vacchiano, Andrew Hacket-Pain, Marco Turco, Renzo Motta, Janet Maringer, Marco Conedera, Igor Drobyshev, Davide Ascoli
Mast seeding is a crucial population process in many tree species, but its spatio-temporal patterns and drivers at the continental scale remain unknown . Using a large dataset (8000 masting observations across Europe for years 1950-2014) we analysed the spatial pattern of masting across the entire geographical range of European beech, how it is influenced by precipitation, temperature and drought, and the temporal and spatial stability of masting-weather correlations. Beech masting exhibited a general distance-dependent synchronicity and a pattern structured in three broad geographical groups consistent with continental climate regimes...
July 2017: New Phytologist
https://www.readbyqxmd.com/read/28629093/novel-pemulen-pullulan-blended-hydrogel-containing-clotrimazole-loaded-cationic-nanocapsules-evaluation-of-mucoadhesion-and-vaginal-permeation
#7
Julia A de Lima, Thamiris C Paines, Mariana H Motta, Watussi B Weber, Sara S Dos Santos, Letícia Cruz, Cristiane de B da Silva
In this work, hydrogels containing clotrimazole-loaded nanocapsules were developed through the innovative association of two mucoadhesive polymers: Pemulen® TR1 and Pullulan. Furthermore, the hydrogels macroscopic characteristics, pH and spreadability were evaluated. The formulations showed homogeneous appearance and pH compatible with vaginal application (around 5.0). Similar spreadability profiles were found in hydrogels containing clotrimazole-loaded nanocapsules and in the free drug as well. Hydrogels were evaluated considering their mucoadhesive potential by the falling liquid film method and the permeation/penetration capacity through cow vaginal mucosa in Franz cell...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628525/assessing-sensitivity-and-specificity-of-the-manchester-triage-system-in-the-evaluation-of-acute-coronary-syndrome-in-adult-patients-in-emergency-care-a-systematic-review
#8
Fernanda Ayache Nishi, Flávia de Oliveira Motta Maia, Itamar de Souza Santos, Dina de Almeida Lopes Monteiro da Cruz
BACKGROUND: Triage is the first assessment and sorting process used to prioritize patients arriving in the emergency department (ED). As a triage tool, the Manchester Triage System (MTS) must have a high sensitivity to minimize the occurrence of under-triage, but must not compromise specificity to avoid the occurrence of overtriage. Sensitivity and specificity of the MTS can be calculated using the frequency of appropriately assigned clinical priority levels for patients presenting to the ED...
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28624818/maternal-subcutaneous-and-visceral-adipose-ultrasound-thickness-in-women-with-gestational-diabetes-mellitus-at-24-28-weeks-gestation
#9
Francesco D'Ambrosi, Francesca Crovetto, Enrico Colosi, Isabella Fabietti, Floriana Carbone, Beatrice Tassis, Silvia Motta, Alessandro Bulfoni, Luigi Fedele, Gabriele Rossi, Nicola Persico
OBJECTIVE: To compare the sonographic measurement of maternal subcutaneous and visceral adipose thickness between pregnant women with gestational diabetes mellitus (GDM) and patients with nondiabetic pregnancies. METHODS: Adipose thickness was measured by transabdominal ultrasound in pregnant women attending our antenatal clinics at 24-28 weeks' gestation. All patients underwent a 75-g oral glucose challenge as a diagnostic test for GDM. RESULTS: The study population comprised 56 women with a positive glucose challenge test and 112 nondiabetic pregnancies...
June 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28622393/giardia-co-infection-promotes-the-secretion-of-antimicrobial-peptides-beta-defensin-2-and-trefoil-factor-3-and-attenuates-attaching-and-effacing-bacteria-induced-intestinal-disease
#10
Anna Manko, Jean-Paul Motta, James A Cotton, Troy Feener, Ayodele Oyeyemi, Bruce A Vallance, John L Wallace, Andre G Buret
Our understanding of polymicrobial gastrointestinal infections and their effects on host biology remains incompletely understood. Giardia duodenalis is an ubiquitous intestinal protozoan parasite infecting animals and humans. Concomitant infections with Giardia and other gastrointestinal pathogens commonly occur. In countries with poor sanitation, Giardia infection has been associated with decreased incidence of diarrheal disease and fever, and reduced serum inflammatory markers release, via mechanisms that remain obscure...
2017: PloS One
https://www.readbyqxmd.com/read/28621833/multiple-external-cervical-root-resorptions-after-home-bleaching-treatment-with-22-carbamide-peroxide
#11
Glauco Rodrigues Velloso, Marcos Motta de Freitas, Adriana Terezinha Neves Novellino Alves, Alan Roger Santos Silva, Eliane Dos Santos Porto Barboza, Vittorio Moraschini
Invasive multiple cervical root resorptions after vital tooth bleaching is a rare condition. The aim of this article is to present a case of multiple external cervical root resorptions (ECRR) after a misguided home whitening treatment. A 34-year-old male patient presented with slight sensitivity and mobility in several teeth. Despite the manufacturer's recommendations, the patient used a 22% carbamide peroxide-based tooth bleaching gel at home for 4 consecutive days, at night, on the upper and lower arches...
June 16, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28620958/a-network-meta-analysis-of-primary-prophylaxis-for-invasive-fungal-infection-in-haematological-patients
#12
REVIEW
L P Leonart, F S Tonin, V L Ferreira, S T S Penteado, A Wiens, F A Motta, R Pontarolo
WHAT IS KNOWN AND OBJECTIVE: Antifungal prophylaxis is an option to reduce the incidence of invasive fungal infection (IFI) in haematological patients. To date, no network meta-analysis (NMA) of high-quality evidence (double-blind randomized controlled trials) has been performed on this subject. This systematic review and NMA aimed to evaluate the safety and efficacy of different antifungal agents used for prophylaxis of IFI in patients with haematological disorders. METHODS: A systematic review was performed according to PRISMA and Cochrane recommendations...
June 15, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28619833/ct-angiography-aspects-predicts-outcome-much-better-than-noncontrast-ct-in-patients-with-stroke-treated-endovascularly
#13
F Sallustio, C Motta, S Pizzuto, M Diomedi, B Rizzato, M Panella, F Alemseged, M Stefanini, S Fabiano, R Gandini, R Floris, P Stanzione, G Koch
BACKGROUND AND PURPOSE: Noncontrast CT ASPECTS has been investigated as a predictor of outcome in patients with acute ischemic stroke. Our purpose was to investigate whether CTA source images are a better predictor of clinical and radiologic outcomes than NCCT ASPECTS in candidates for endovascular stroke therapy. MATERIALS AND METHODS: CT scans of patients (n = 124) were independently evaluated by 2 readers for baseline NCCT and CTA source image ASPECTS and for follow-up ASPECTS...
June 15, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28618984/glycemic-variability-and-insulin-needs-in-patients-with-type-1-diabetes-mellitus-supplemented-with-vitamin-d-a-pilot-study-using-continuous-glucose-monitoring-system
#14
Karem Miléo Felício, Ana Carolina Contente Braga de Souza, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Thaís Pontes Arbage, Hana Andrade de Rider Brito, Amanda Soares Peixoto, Alana Ferreira de Oliveira, Fabricio de Souza Resende, Scarlatt Sousa Reis, Ana Regina Motta, Henrique da Costa Miranda, Luísa Corrêa Janaú, Elizabeth Sumi Yamada, João Soares Felício
BACKGROUND: Recent studies suggest that glycemic variability could influence the risk of complications in type 1 diabetes mellitus (T1DM). There are no data about the action of vitamin D (VD) on glycemic variability. Our pilot study aims to evaluate glycemic variability and insulin needs in patients with T1DM supplemented with VD. METHODS: 22 patients received doses of 4000 and 10000 IU/day of cholecalciferol for 12 weeks, according to the patient's baseline VD levels and underwent continuous glucose monitoring system...
June 15, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28617714/perioperative-chemotherapy-with-and-without-high-dose-methotrexate-in-adult-osteosarcoma
#15
Marcelo Vailati Negrão, Lucila S da Silva Rocha, Daniel da Motta Girardi, Olavo Feher
Treatment of adult osteosarcoma (AOS) includes perioperative chemotherapy and surgery. Standard chemotherapy consists of cisplatin (CP) and doxorubicin (DOX). Although considered the standard of care for pediatric patients, high-dose methotrexate (HDM) remains controversial in adults. We aimed to evaluate the role of HDM in AOS treated with curative intent. This study included patients with AOS who received perioperative chemotherapy with DOX and CP (group 1; N=16) and DOX, CP, and HDM (group 2; N=10). The primary endpoint was grade 3 or superior toxicities...
June 14, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28617073/metabolomics-of-exhaled-breath-condensate-a-means-for-phenotyping-respiratory-diseases
#16
Mauro Maniscalco, Andrea Motta
No abstract text is available yet for this article.
June 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28616990/modeling-binding-with-large-conformational-changes-key-points-in-ensemble-docking-approaches
#17
Stefano Motta, Laura Bonati
Protein dynamics play a critical role in ligand binding, and different models have been proposed to explain the relationships between protein motion and molecular recognition. Here, we present a study of ligand-binding processes associated with large conformational changes of a protein to elucidate the critical choices in ensemble-docking approaches for effective prediction of the binding geometry. Two study cases were selected in which binding involves different protein motions and intermolecular interactions and, accordingly, conformational selection and induced-fit mechanisms play different roles: binding of multiple ligands to the acetylcholine binding protein and highly specific binding of D-allose to the allose binding protein...
June 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28609273/knowledge-regarding-fertility-preservation-in-cancer-patients-a-population-based-survey-among-brazilian-people-during-the-pink-october-awareness-event
#18
Mauricio B Chehin, Tatiana Cs Bonetti, Paulo C Serafini, Eduardo LA Motta
OBJECTIVE: The aim of this study was to assess the knowledge about the risk of infertility in cancer patients after treatment, and the options for fertility preservation based on a survey carried out during the 2013 Pink October campaign. METHODS: This survey was carried out during the 2013 Pink October event in the most important public park of São Paulo, Brazil. Approximately 900 people expressed interest in learning about breast cancer prevention and fertility preservation by participating in workshops, and 242 people filled out a questionnaire...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28609091/supercapacitor-electrodes-with-remarkable-specific-capacitance-converted-from-hybrid-graphene-oxide-nacl-urea-films
#19
Yi Zhao, Jinzhang Liu, Bin Wang, Jiangbo Sha, Yan Li, Dezhi Zheng, Mojtaba Amjadipour, Jennifer M Macleod, Nunzio Motta
A novel approach to improve the specific capacitance of reduced graphene oxide (rGO) films is reported. We combine the aqueous dispersion of liquid-crystalline GO incorporating salt and urea with a blade-coating technique to make hybrid films. After drying, stacked GO sheets mediated by solidified NaCl and urea are hydrothermally reduced, resulting in a nanoporous film consisting of rumpled N-doped rGO sheets. As a supercapacitor electrode, the film exhibits a high gravimetric specific capacitance of 425 F g(-1) and a record volumetric specific capacitance of 693 F cm(-3) at 1 A g(-1) in 1 M H2SO4 aqueous electrolyte when integrated into a symmetric cell...
June 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28608290/titanium-and-iron-titanium-oxide-nanoparticles-in-antennae-of-the-migratory-ant-pachycondyla-marginata-an-alternative-magnetic-sensor-for-magnetoreception
#20
Eliane Wajnberg, André Linhares Rossi, Darci Motta S Esquivel
The most accepted hypothesis of magnetoreception for social insects is the ferromagnetic hypothesis which assumes the presence of magnetic material as a sensor coupled to sensitive structures that transmit the geomagnetic field information to the nervous system. As magnetite is the most common magnetic material observed in living beings, it has been suggested as basic constituent of the magnetoreception system. Antennae and head have been pointed as possible magnetosensor organs in social insects as ants, bees and termites...
June 12, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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