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https://www.readbyqxmd.com/read/28944112/excellent-response-with-ado-trastuzumab-emtansine-in-a-patient-with-relapsed-metastatic-breast-cancer-presenting-with-pulmonary-lymphangitic-carcinomatosis
#1
Zhou Yu, Shobana Sankar, Marianne Huben
In breast cancer, aggressive tumor biology and the corresponding poor prognosis is associated with amplification or overexpression of the human epidermal growth factor receptor 2 (HER2). Trastuzumab has significantly changed the natural history of HER2-positive breast cancer. However, resistance to trastuzumab remains a substantial clinical problem. Ado-trastuzumab emtansine (T-DM1), an antibody-drug conjugate, has demonstrated impressive results in second- or later-line treatment of HER2-positive breast cancer...
July 14, 2017: Curēus
https://www.readbyqxmd.com/read/28940260/authentication-of-m14-melanoma-cell-line-proves-misidentification-of-mda-mb-435-breast-cancer-cell-line
#2
Christopher Korch, Erin M Hall, Wilhelm G Dirks, Margaret Ewing, Mark Faries, Marileila Varella-Garcia, Steven Robinson, Douglas Storts, Jacqueline A Turner, Ying Wang, Edward C Burnett, Lyn Healy, Douglas Kniss, Richard M Neve, Raymond W Nims, Yvonne A Reid, William A Robinson, Amanda Capes-Davis
A variety of analytical approaches have indicated that melanoma cell line UCLA-SO-M14 (M14) and breast carcinoma cell line MDA-MB-435 originate from a common donor. This indicates that at some point in the past, one of these cell lines became misidentified, meaning that it ceased to correspond to the reported donor and instead became falsely identified (through cross-contamination or other means) as a cell line from a different donor. Initial studies concluded that MDA-MB-435 was the misidentified cell line and M14 was the authentic cell line, although contradictory evidence has been published, resulting in further confusion...
September 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28940212/no-induced-mutagenesis-in-human-lymphoblast-cell-line-and-bacterial-systems-upon-their-prolonged-sub-culturing-in-irradiated-food-blended-media
#3
Sudhanshu Saxena, Sanjeev Kumar, Jyoti Tripathi, Satyendra Gautam
BACKGROUND: Confound apprehension towards safety of irradiated food has remained a major cause behind tardy acceptance of this technology though it has immense socio-economic potential. Generation of in depth scientific evidences will help to refute these apprehensions. With this prospective, present study was undertaken where safety of various irradiated (Dmin up to 25 kGy) foods was evaluated through long term exposure studies in models including human lymphoblast TK6 cell line (100 generations) and Escherichia coli MG1655 cells (exclusive subcuturing in irradiated food medium for 3000 generations)...
September 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28938609/pegylated-arginine-deiminase-can-modulate-tumor-immune-microenvironment-by-affecting-immune-checkpoint-expression-decreasing-regulatory-t-cell-accumulation-and-inducing-tumor-t-cell-infiltration
#4
Elena Brin, Katherine Wu, Hsin-Tze Lu, Yudou He, Zhaoming Dai, Wei He
PEGylated arginine deiminase (ADI-PEG 20) is being investigated in clinical studies in arginine auxotrophic cancers and is well-tolerated. The anti-tumor properties of ADI-PEG 20 have been extensively investigated - ADI-PEG 20 inhibits the growth of auxotrophic cancers in vitro and in vivo - however, its impact on immune cells is largely unknown. Here we report the potential impact of ADI-PEG 20 on the tumor immune microenvironment. ADI-PEG 20 induced immunosuppressive programmed death-ligand 1 expression on some cancer cells in vitro, but the magnitude of the increase was cell line dependent and in most relatively small...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938361/columellar-reconstruction-following-nasal-cpap-injury
#5
Catherine S Chang, Jordan W Swanson, Anthony Wilson, David W Low, Scott P Bartlett
Nasal continuous positive airway pressure (nCPAP) is utilized increasingly to treat pulmonary immaturity in premature neonates. Nasal injury is common with nCPAP use, with full thickness tissue loss at the columella among the most devastating complications.Columellar necrosis often imparts a full thickness injury to the overlying columellar skin, the medial crura of the lower lateral nasal cartilages, as well as the anteromedial inner nasal mucosal lining, and potentially the anterior septal cartilage. Consequently, the columella can become scarred and shortened...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28935604/molecular-features-and-physiological-roles-of-k-cl-cotransporter-4-kcc4
#6
REVIEW
A A Marcoux, A P Garneau, R Frenette-Cotton, S Slimani, F Mac-Way, P Isenring
A K(+)-Cl(-) cotransport system was documented for the first time during the mid-seventies in sheep and goat red blood cells. It was then described as a Na(+)-independent and ouabain-insensitive ion carrier that could be stimulated by cell swelling and N-ethylmaleimide (NEM), a thiol-reacting agent. Twenty years later, this system was found to be dispensed by four different isoforms in animal cells. The first one was identified in the expressed sequence tag (EST) database by Gillen et al. based on the assumption that it would be homologous to the Na(+)-dependent K(+)-Cl(-) cotransport system for which the molecular identity had already been uncovered...
September 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28935011/-correlation-between-serum-tumor-markers-and-efficacy-of-first-line-egfr-tkis-in-patients-with-advanced-lung-adenocarcinoma
#7
Hanxiao Chen, Xue Yang, Huijun Liu, Kun Ma, Jia Zhong, Zhi Dong, Minglei Zhuo, Yuyan Wang, Jianjie Li, Tongtong An, Meina Wu, Ziping Wang, Jun Zhao
BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) significantly improve the survival of advanced lung adenocarcinoma patients harboring EGFR mutation. Limited to the standards of tumor tissue samples and detection methods, still some people can't receive target therapy following genetic guidance. This study was to explore the relevance between serum tumor markers and treatment of EGFR-TKIs. METHODS: We retrospectively collected the clinical information of advanced lung adenocarcinoma patients harboring EGFR mutation, who received EGFR-TKIs as first-line therapy from June 2009 to June 2014 in Peking University Cancer Hospital, analyzed the relationship between serum tumor markers and efficacy of EGFR-TKIs...
September 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28934128/neuroticism-predicts-subsequent-risk-of-major-depression-for-whites-but-not-blacks
#8
Shervin Assari
Cultural and ethnic differences in psychosocial and medical correlates of negative affect are well documented. This study aimed to compare blacks and whites for the predictive role of baseline neuroticism (N) on subsequent risk of major depressive episodes (MDD) 25 years later. Data came from the Americans' Changing Lives (ACL) Study, 1986-2011. We used data on 1219 individuals (847 whites and 372 blacks) who had data on baseline N in 1986 and future MDD in 2011. The main predictor of interest was baseline N, measured using three items in 1986...
September 21, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28933984/differentiation-of-lepidoptera-scale-cells-from-epidermal-stem-cells-followed-by-ecdysone-regulated-dna-duplication-and-scale-secreting
#9
Shenglei Yuan, Wuren Huang, Lei Geng, Brenda T Beerntsen, Hongsheng Song, Erjun Ling
Integuments are the first line to protect insects from physical damage and pathogenic infection. In lepidopteran insects, they undergo distinct morphology changes such as scale formation during metamorphosis. However, we know little about integument development and scale formation during this stage. Here, we use the silkworm, Bombyx mori, as a model and show that stem cells in the integument of each segment, but not intersegmental membrane, divide into two scale precursor cells during the spinning stage. In young pupae, the scale precursor cell divides again...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933271/targeting-cell-necroptosis-and-apoptosis-induced-by-shikonin-via-receptor-interacting-protein-kinases-in-estrogen-receptor-positive-breast-cancer-cell-line-mcf-7
#10
Zahra Shahsavari, Fatemeh Karami-Tehrani, Siamak Salami
Recognition of a new therapeutic agent may activate an alternative programmed cell death for the treatment of breast cancer. Here, it has been tried to evaluate the effects of Shikonin, a naphthoquinone derivative of Lithospermum erythrorhizon, on the induction of necroptosis and apoptosis mediated by RIPK1-RIPK3 in the ER+ breast cancer cell line, MCF-7. In the current study, cell death modalities, cell cycle patterns, RIPK1 and RIPK3 expressions, caspase-3 and caspase-8 activities, reactive oxygen species and mitochondrial membrane potential have been evaluated in the Shikonin-treated MCF-7 cells...
September 19, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28932033/glandular-odontogenic-cyst-series-of-five-cases
#11
Aadithya B Urs, Priya Kumar, Jeyaseelan Augustine, Rewa Malhotra
INTRODUCTION: Glandular odontogenic cyst (GOC) is a clinically rare and histopathologically unusual type of developmental odontogenic cyst with unpredictable and potentially aggressive behaviour. MATERIALS AND METHODS: Archival data of cases histopathologically identified as GOC were analyzed from the Department of Oral Pathology over the past six years. The clinical, radiographic, histopathological features and treatment were evaluated. Special stains such as periodic acid Schiff, mucicarmine along with immunohistochemical staining for cytokeratin 19 were employed to confirm the histopathological diagnosis...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28928695/moderate-contrast-in-the-evaluation-of-paintings-is-liked-more-but-remembered-less-than-high-contrast
#12
Katinka Dijkstra, Noah N N van Dongen
Many visual aspects of paintings, as well as exposure to art and cultural norms, contribute to the aesthetic evaluation of paintings. The current study looked at heightened visual contrast as an important factor in the appreciation of paintings. Participants evaluated abstract digitized paintings that were manipulated in contrast for an appreciation task and were later presented with these paintings in a memory task. The results indicated that for art appreciation, a moderate increase in contrast resulted in the highest appreciation for paintings whereas recognition memory was better for paintings with a higher increase in contrast...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28928635/d-tubocurarine-and-berbamine-alkaloids-that-are-permeant-blockers-of-the-hair-cell-s-mechano-electrical-transducer-channel-and-protect-from-aminoglycoside-toxicity
#13
Nerissa K Kirkwood, Molly O'Reilly, Marco Derudas, Emma J Kenyon, Rosemary Huckvale, Sietse M van Netten, Simon E Ward, Guy P Richardson, Corné J Kros
Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged following entry of these antibiotics via the mechano-electrical transducer (MET) channels located at the tips of the hair cell's stereocilia. d-Tubocurarine (dTC) is a MET channel blocker that reduces the loading of gentamicin-Texas Red (GTTR) into rat cochlear hair cells and protects them from gentamicin treatment...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28927879/effects-of-volar-tilt-wrist-extension-and-plate-position-on-contact-between-flexor-pollicis-longus-tendon-and-volar-plate
#14
Caroline N Wolfe Wurtzel, Geoffrey T Burns, Andy F Zhu, Kagan Ozer
PURPOSE: Volar plates positioned at, or distal to, the watershed line have been shown to have a higher incidence of attritional rupture of the flexor pollicis longus (FPL). In this study, we aimed to evaluate the effect of wrist extension and volar tilt on the contact between the plate and the FPL tendon in a cadaver model. We hypothesized that, following volar plate application, loss of native volar tilt increases the contact between the FPL and the plate at lower degrees of wrist extension...
September 16, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28927806/-aging-prevention-new-surgical-techniques-and-future-options-for-facial-rejuvenation
#15
C Le Louarn
Prevention of aging is mainly obtained through appropriate health practices, modulated by the genetic causes of aging. Causes of facial structural aging include gravity, volume loss, contraction of the mimic muscles and obviously biological aging of tissues. Among the very numerous new surgical technique of facial rejuvenation, we could point out: for the frontal region, obviously we are focus on the endoscopic and non-endoscopic frontal lifts. But also, we should note the transcutaneous Brow Shaping which with a well defined, step by step technique is indeed a simple way to improve a possible difficult situation; concerning the mid-face lift, as the main risk is the secondary eyelid malposition, a high Smas or a temporo-malar lift can be performed...
September 15, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28926609/developmental-expression-of-membrane-type-4-matrix-metalloproteinase-mt4-mmp-mmp17-in-the-mouse-embryo
#16
María José Blanco, Iván Rodríguez-Martín, Ana I R Learte, Cristina Clemente, María Gregoria Montalvo, Motoharu Seiki, Alicia G Arroyo, Cristina Sánchez-Camacho
Matrix metalloproteinases (MMPs) constitute a large group of endoproteases that play important functions during embryonic development, tumor metastasis and angiogenesis by degrading components of the extracellular matrix. Within this family, we focused our study on Mt4-mmp (also called Mmp17) that belongs to a distinct subset that is anchored to the cell surface via a glycosylphosphatidylinositol (GPI) moiety and with the catalytic site exposed to the extracellular space. Information about its function and substrates is very limited to date, and little has been reported on its role in the developing embryo...
2017: PloS One
https://www.readbyqxmd.com/read/28924248/adaptive-pixel-super-resolved-lensfree-in-line-digital-holography-for-wide-field-on-chip-microscopy
#17
Jialin Zhang, Jiasong Sun, Qian Chen, Jiaji Li, Chao Zuo
High-resolution wide field-of-view (FOV) microscopic imaging plays an essential role in various fields of biomedicine, engineering, and physical sciences. As an alternative to conventional lens-based scanning techniques, lensfree holography provides a new way to effectively bypass the intrinsical trade-off between the spatial resolution and FOV of conventional microscopes. Unfortunately, due to the limited sensor pixel-size, unpredictable disturbance during image acquisition, and sub-optimum solution to the phase retrieval problem, typical lensfree microscopes only produce compromised imaging quality in terms of lateral resolution and signal-to-noise ratio (SNR)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923486/retinoic-acid-is-required-and-fgf-wnt-and-bmp-signaling-inhibit-posterior-lateral-line-placode-induction-in-zebrafish
#18
Masataka Nikaido, Joaquin Navajas Acedo, Kohei Hatta, Tatjana Piotrowski
The lateral line system is a mechanosensory systems present in aquatic animals. The anterior and posterior lateral lines develop from anterior and posterior lateral line placodes (aLLp and pLLp), respectively. Although signaling molecules required for the induction of other cranial placodes have been well studied, the molecular mechanisms underlying formation of the lateral line placodes are unknown. In this study we tested the requirement of multiple signaling pathways, such as Wnt, Bmp Fgf, and Retinoic Acid for aLLp and pLLp induction...
September 18, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28923290/use-of-adult-sensory-panel-to-study-individual-differences-in-the-palatability-of-a-pediatric-hiv-treatment-drug
#19
Julie A Mennella, Phoebe S Mathew, Elizabeth D Lowenthal
PURPOSE: The recommended first-line treatment for young children infected with HIV includes the liquid formulation of the co-formulated protease inhibitors lopinavir/ritonavir (Kaletra(®) [Abbott Laboratories, Chicago, Illinois]). Clinical reports indicate that some children readily accept the taste of Kaletra, whereas others strongly reject it, which can deter therapeutic adherence and outcomes. METHODS: As a proof-of-concept approach, a sensory panel of genotyped adults was used to document the range of individual differences in the taste and palatability (hedonics) of the liquid formulation of Kaletra and other taste stimuli, including common excipients...
September 15, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28922610/symbiosis-of-selected-rhizobium-leguminosarum-bv-viciae-strains-with-diverse-pea-genotypes-effects-on-biological-nitrogen-fixation
#20
Chao Yang, Rosalind Bueckert, Jeff Schoenau, Axel Diederichsen, Hossein Zakeri, Thomas Warkentin
Biological nitrogen fixation (BNF) can be improved by optimizing the interaction between the rhizobial inoculant and pea (Pisum sativum L.), leading to increased productivity and reduced nitrogen (N) fertilizer use. Eight Rhizobium leguminosarum bv. viciae strains were used to inoculate super-nodulating pea mutant Rondo-nod3(fix+), hyper-nodulating pea mutant Frisson P88 Sym29, CDC Meadow commercial control, and a non-nodulating mutant Frisson P56 (nod-) to evaluate BNF in a greenhouse assay. Significant differences in strain×cultivar interactions were detected for shoot and root dry weight which ranged from 1...
September 18, 2017: Canadian Journal of Microbiology
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