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https://www.readbyqxmd.com/read/29352436/posterolateral-tibial-plateau-fractures-how-to-buttress-reversed-l-posteromedial-or-the-posterolateral-approach-a-comparative-cadaveric-study
#1
Wich Orapiriyakul, Theerachai Apivatthakakul, Chanakarn Phornphutkul
INTRODUCTION: The selection of a surgical approach for buttressing posterolateral tibial plateau fractures is controversial. OBJECTIVE: This study compared the surgical exposure area between the reversed L posteromedial approach (R-PM) and the posterolateral (PL) approach using the lateral plateau width as a metric. MATERIALS AND METHODS: Twenty lower extremities from fresh frozen cadavers were included. The R-PM approach was used first and the boundary of the posterior tibial cortex exposure was marked with metal pins...
January 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29352045/eliminating-glutamatergic-input-onto-horizontal-cells-changes-the-dynamic-range-and-receptive-field-organization-of-mouse-retinal-ganglion-cells
#2
Sebastian Ströh, Christian Puller, Sebastian Swirski, Maj-Britt Hölzel, Lea I S van der Linde, Jasmin Segelken, Konrad Schultz, Christoph Block, Hannah Monyer, Klaus Willecke, Reto Weiler, Martin Greschner, Ulrike Janssen-Bienhold, Karin Dedek
In the mammalian retina, horizontal cells receive glutamatergic inputs from many rod and cone photoreceptors and return feedback signals to them, thereby changing photoreceptor glutamate release in a light-dependent manner. Horizontal cells also provide feedforward signals to bipolar cells. It is unclear, however, how horizontal cell signals also affect the temporal, spatial and contrast tuning in retinal output neurons, the ganglion cells. To study this, we generated a genetically modified mouse line in which we eliminated the light dependency of feedback by deleting glutamate receptors from mouse horizontal cells...
January 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29351679/landmarks-for-identifying-the-suprascapular-foramen-anteriorly-application-to-anterior-neurotization-and-decompressive-procedures
#3
Olga V Manouvakhova, Veronica Macchi, Fabian N Fries, Marios Loukas, Raffaele De Caro, Rod J Oskouian, Robert J Spinner, R Shane Tubbs
BACKGROUND: Additional landmarks for identifying the suprascapular nerve at its entrance into the suprascapular foramen from an anterior approach would be useful to the surgeon. OBJECTIVE: To identify landmarks for the identification of this hidden site within an anterior approach. METHODS: In 8 adult cadavers (16 sides), lines were used to connect the superior angle of the scapula, the acromion, and the coracoid process tip thus creating an anatomic triangle...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29349573/mesencephalic-astrocyte-derived-neurotrophic-factor-manf-elevates-stimulus-evoked-release-of-dopamine-in-freely-moving-rats
#4
Juho-Matti Renko, Susanne Bäck, Merja H Voutilainen, T Petteri Piepponen, Ilkka Reenilä, Mart Saarma, Raimo K Tuominen
Neurotrophic factors (NTFs) hold potential as disease-modifying therapies for neurodegenerative disorders like Parkinson's disease. Glial cell line-derived neurotrophic factor (GDNF), cerebral dopamine neurotrophic factor (CDNF), and mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown neuroprotective and restorative effects on nigral dopaminergic neurons in various animal models of Parkinson's disease. To date, however, their effects on brain neurochemistry have not been compared using in vivo microdialysis...
January 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29348023/impaired-recovery-of-left-ventricular-function-in-patients-with-cardiomyopathy-and-left%C3%A2-bundle-branch-block
#5
Edward Sze, Zainab Samad, Allison Dunning, Kristen Bova Campbell, Zak Loring, Brett D Atwater, Karen Chiswell, Joseph A Kisslo, Eric J Velazquez, James P Daubert
BACKGROUND: Patients with left bundle branch block (LBBB) often respond to cardiac resynchronization therapy (CRT) with left ventricular ejection fraction (LVEF) improvement. Guideline-directed medical therapy (GDMT), not CRT, is first-line therapy for patients with reduced LVEF with LBBB. However, there are little data on how patients with reduced LVEF and LBBB respond to GDMT. OBJECTIVES: This study examined patients with cardiomyopathy and sought to assess rates of LVEF improvement for patients with LBBB compared to other QRS morphologies...
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29346567/epithelial-grafting-of-a-decellularized-whole-tracheal-segment-an-in-vivo-experimental-model
#6
Margot Den Hondt, Bart M Vanaudenaerde, Eric K Verbeken, Jan J Vranckx
OBJECTIVES: Prerequisites for successful trachea transplantation include the use of a biocompatible construct, submucosal vascularization and an epithelial covering. Implantation of non-epithelialized tracheal scaffolds may lead to stenosis. However, epithelial grafting or seeding can only be attempted onto a well-vascularized submucosal bed. Our aim was to investigate a method to prevent stenosis during prelamination of non-epithelialized, gently decellularized rabbit tracheae and to evaluate whether grafting of revascularized constructs with buccal mucosa is feasible...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29345950/confined-electroconvective-vortices-at-structured-ion-exchange-membranes
#7
Joeri de Valença, Morten Jõgi, R Martijn Wagterveld, Elif Karatay, Jeffery A Wood, Rob G H Lammertink
In this paper, we investigate electroconvective ion transport at cation exchange membranes with different geometry square-wave structures (line undulations) experimentally and numerically. Electroconvective micro-vortices are induced by strong concentration polarization once a threshold potential difference is applied. The applied potential required to start and sustain electroconvection is strongly affected by the geometry of the membrane. A reduction in the resistance of approximately 50% can be obtained when the structure size is similar to the mixing layer thickness, resulting in confined vortices with less lateral motion compared to the case of flat membranes...
January 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29344523/clinical-skills-temporal-degradation-assessment-in-undergraduate-medical-education
#8
Joseph Fisher, Rebecca Viscusi, Adam Ratesic, Cameron Johnstone, Ross Kelley, Angela M Tegethoff, Jessica Bates, Elaine H Situ-Lacasse, William J Adamas-Rappaport, Richard Amini
Introduction: Medical students' ability to learn clinical procedures and competently apply these skills is an essential component of medical education. Complex skills with limited opportunity for practice have been shown to degrade without continued refresher training. To our knowledge there is no evidence that objectively evaluates temporal degradation of clinical skills in undergraduate medical education. The purpose of this study was to evaluate temporal retention of clinical skills among third year medical students...
January 2018: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/29344324/treatment-of-lateral-periorbital-lines-with-different-dilutions-of-incobotulinumtoxina
#9
Gabriele F Muti, Matteo Basso
BACKGROUND: IncobotulinumtoxinA is a botulinum neurotoxin type A that is free from complexing proteins and is used in various therapeutic indications and aesthetic medicine. It is approved for the treatment of glabellar frown lines in the United States. In Europe, it is also approved for the treatment of lateral periorbital lines (crow's feet) and for the combined treatment of upper facial lines, including glabellar frown lines, crow's feet, and horizontal forehead lines. METHODS: In the present study, incobotulinumtoxinA was injected at two different dilutions to treat female subjects aged 40 to 50 years who had moderate-to-severe lateral periorbital lines at maximum contraction according to a score of 2 or 3 points on the 5-point Merz Aesthetics Scales (MAS)...
September 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29344247/upregulation-of-the-checkpoint-protein-chfr-is-associated-with-tumor-suppression-in-pancreatic-cancers
#10
Di Zhang, Xiao-Lan Xu, Fei Li, Hai-Chen Sun, Ye-Qing Cui, Shuang Liu, Ping-Yong Xu
The checkpoint with forkhead-associated (FHA) domain and RING-finger (CHFR) protein was identified as a cell cycle checkpoint protein and E3 ubiquitin ligase. In the present study, the potential functions of CHFR in pancreatic cancer were investigated. CHFR expression was measured in five pancreatic cancer cell lines by reverse transcription- quantitative polymerase chain reaction and western blotting. Capan-1 cells stably expressing CHFR were established by lentiviral vector transfection. Cell proliferation was assessed using Cell Counting Kit-8, and cell migration/invasion assay was determined using Transwell assays...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343808/stereotactic-topography-of-the-greater-and-third-occipital-nerves-and-its-clinical-implication
#11
Hong-San Kim, Kang-Jae Shin, Jehoon O, Hyun-Jin Kwon, Minho Lee, Hun-Mu Yang
This study aimed to provide topographic information of the greater occipital (GON) and third occipital (3ON) nerves, with the three-dimensional locations of their emerging points on the back muscles (60 sides, 30 cadavers) and their spatial relationship with muscle layers, using a 3D digitizer (Microscribe G2X, Immersion Corp, San Jose CA, USA). With reference to the external occipital protuberance (EOP), GON pierced the trapezius at a point 22.6 ± 7.4 mm lateral and 16.3 ± 5.9 mm inferior and the semispinalis capitis (SSC) at a point 13...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343640/single-cell-transcriptomics-of-the-developing-lateral-geniculate-nucleus-reveals-insights-into-circuit-assembly-and-refinement
#12
Brian T Kalish, Lucas Cheadle, Sinisa Hrvatin, M Aurel Nagy, Samuel Rivera, Megan Crow, Jesse Gillis, Rory Kirchner, Michael E Greenberg
Coordinated changes in gene expression underlie the early patterning and cell-type specification of the central nervous system. However, much less is known about how such changes contribute to later stages of circuit assembly and refinement. In this study, we employ single-cell RNA sequencing to develop a detailed, whole-transcriptome resource of gene expression across four time points in the developing dorsal lateral geniculate nucleus (LGN), a visual structure in the brain that undergoes a well-characterized program of postnatal circuit development...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29342275/hot-spot-kif5a-mutations-cause-familial-als
#13
David Brenner, Rüstem Yilmaz, Kathrin Müller, Torsten Grehl, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Wolfgang Ruf, Christoph Neuwirth, Markus Weber, Susana Pinto, Kristl G Claeys, Berthold Schrank, Berit Jordan, Antje Knehr, Kornelia Günther, Annemarie Hübers, Daniel Zeller, Christian Kubisch, Sibylle Jablonka, Michael Sendtner, Thomas Klopstock, Mamede de Carvalho, Anne Sperfeld, Guntram Borck, Alexander E Volk, Johannes Dorst, Joachim Weis, Markus Otto, Joachim Schuster, Kelly Del Tredici, Heiko Braak, Karin M Danzer, Axel Freischmidt, Thomas Meitinger, Tim M Strom, Albert C Ludolph, Peter M Andersen, Jochen H Weishaupt
Heterozygous missense mutations in the N-terminal motor or coiled-coil domains of the kinesin family member 5A (KIF5A) gene cause monogenic spastic paraplegia (HSP10) and Charcot-Marie-Tooth disease type 2 (CMT2). Moreover, heterozygous de novo frame-shift mutations in the C-terminal domain of KIF5A are associated with neonatal intractable myoclonus, a neurodevelopmental syndrome. These findings, together with the observation that many of the disease genes associated with amyotrophic lateral sclerosis disrupt cytoskeletal function and intracellular transport, led us to hypothesize that mutations in KIF5A are also a cause of amyotrophic lateral sclerosis...
January 12, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29340993/laparoscopic-assisted-modified-intersphincter-resection-for-ultralow-rectal-cancer
#14
Haiyang Zhou, Canping Ruan, Zhiguo Wang, Zhiqian Hu
BACKGROUND: Intersphincter resection (ISR) is considered to be a superior technique offering sphincter preservation in patients with ultralow rectal cancer.1 Because high-definition laparoscopy offers wider and clearer vision into the narrow pelvic cavity and intersphincteric space, ISR has been further refined.2 However, functional outcome after ISR has not been optimal. More than half of patients receiving ISR suffer partial or even complete anal incontinence.3 We therefore propose a laparoscopic-assisted modified ISR, with the aim of improving sphincter function following ISR...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29339813/a-new-group-of-synthetic-phenolic-containing-amphiphilic-molecules-for-multipurpose-applications-physico-chemical-characterization-and-cell-toxicity-study
#15
Sampson Anankanbil, Bianca Pérez, Iva Fernandes, Katarzyna Magdalena Widzisz, Zegao Wang, Nuno Mateus, Zheng Guo
Nine synthetic amphiphilic phenolic lipids, varied in phenolic moiety (caffeoyl/dimethylcaffeoyl) and fatty acid chain lengths (8-18) were characterized by differential scanning calorimetry (DSC), temperature-ramp Fourier transform infra-red spectroscopy (FT-IR) and atomic force microscopy (AFM). FT-IR and DSC results revealed that the physical state and lateral packing of synthetic molecules were largely governed by fatty acyls. The critical micelle concentrations (CMC) of synthetic lipids was in the range of 0...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337067/the-impact-of-growth-factors-on-human-induced-pluripotent-stem-cells-differentiation-into-cardiomyocytes
#16
Marianne E Yassa, Iman A Mansour, Nadia I Sewelam, Hala Hamza, Taghrid Gaafar
Human induced pluripotent stem cells (hiPSCs) act as a promising therapeutic alternative for cardiovascular diseases. They yield a large number of functional cardiomyocytes (CMs) from autologous cell sources without ethical or immunological problems. However, significant limitations still remain in terms of line-to-line variability in CM yield and reproducibility. AIM: To efficiently enhance NP0040 hiPSCs differentiation into CMs. MAIN METHODS: Following a standard cardiac differentiation protocol using small molecules targeting the canonical Wnt signaling, growth factors (BMP4 and FGF2) and ascorbic acid were added further in order to increase the cardiac differentiation efficiency...
January 11, 2018: Life Sciences
https://www.readbyqxmd.com/read/29337012/expanding-the-limits-of-endoscopic-intraorbital-tumor-resection-using-3-dimensional-reconstruction
#17
Luciano Lobato Gregorio, Nicolas Y Busaba, Marcel M Miyake, Suzanne K Freitag, Benjamin S Bleier
INTRODUCTION: Endoscopic orbital surgery is a nascent field and new tools are required to assist with surgical planning and to ascertain the limits of the tumor resectability. OBJECTIVE: We purpose to utilize three-dimensional radiographic reconstruction to define the theoretical lateral limit of endoscopic resectability of primary orbital tumors and to apply these boundary conditions to surgical cases. METHODS: A three-dimensional orbital model was rendered in 4 representative patients presenting with primary orbital tumors using OsiriX open source imaging software...
December 26, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29336775/neural-correlates-of-emotional-action-control-in-anger-prone-women-with-borderline-personality-disorder
#18
Katja Bertsch, Karin Roelofs, Paul Jonathan Roch, Bo Ma, Saskia Hensel, Sabine C Herpertz, Inge Volman
BACKGROUND: Difficulty in controlling emotional impulses is a crucial component of borderline personality disorder (BPD) that often leads to destructive, impulsive behaviours against others. In line with recent findings in aggressive individuals, deficits in prefrontal amygdala coupling during emotional action control may account for these symptoms. METHODS: To study the neurobiological correlates of altered emotional action control in individuals with BPD, we asked medication-free, anger-prone, female patients with BPD and age- and intelligence-matched healthy women to take part in an approach-avoidance task while lying in an MRI scanner...
January 12, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29336694/-it-has-changed-my-whole-life-the-systemic-implications-of-chronic-low-back-pain-among-older-adults
#19
Meredith L Stensland, Sara Sanders
Chronic low back pain (CLBP) is the most common pain complaint among older adults. Despite its prevalence, very little research has qualitatively examined the diverse consequences of living with CLBP in later life. As part of a larger study aiming to understand the experience of CLBP among older adults, the objective of this manuscript is to understand how older adults experience CLBP and its impacts on the functioning of older adults. Guided by van Manen's phenomenological method, 23 semi-structured interviews with 21 pain clinic patients aged 66-83 were conducted...
January 16, 2018: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/29336294/esthetic-nasolabial-angle-according-to-the-degree-of-upper-lip-protrusion-in-an-asian-population
#20
So Young Choi, Su Jin Kim, Ho Yun Lee, Dong Sik Chang, Myoung Su Choi
BACKGROUND: The positioning of the nasal tip is as esthetically important as the tip projection when rhinoplasty is being considered. It is not uncommon for Asians to have a protruding upper lip and teeth that affect the nasolabial angle (NLA). This study aimed to find the preferred NLA according to the degree of upper lip protrusion in an Asian population. METHODS: A left-side lateral photograph of each participant was used for simulation of six different tip angles by using a photoshop program...
January 1, 2018: American Journal of Rhinology & Allergy
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