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https://www.readbyqxmd.com/read/28449509/rapid-response-in-a-critical-lung-adenocarcinoma-presenting-as-large-airway-stenoses-after-receiving-stent-implantation-and-sequential-rebiopsy-guided-alk-inhibitor-therapy-a-case-report
#1
Ling Ding, Cheng Chen, Yuan-Yuan Zeng, Jian-Jie Zhu, Jian-An Huang, Ye-Han Zhu
Airway stent implantation can improve the symptoms of airway stenosis caused by a malignant tumor immediately. However, stent implantation is only a palliative therapy and disease will quickly progress without subsequent treatment. Targeted therapy can provide accurate etiological treatment for patients with critical lung cancer who cannot receive chemotherapies. In our clinic, we encountered a 50-year-old male presenting with stage IV lung adenocarcinoma. He failed both the first-line and second-line chemotherapies and suffered severe complex left and right main bronchial stenoses caused by tumor invasion...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448624/overexpression-of-the-protein-phosphatase-2a-regulatory-subunit-a-gene-zmpp2aa1-improves-low-phosphate-tolerance-by-remodeling-the-root-system-architecture-of-maize
#2
Jiemin Wang, Laming Pei, Zhe Jin, Kewei Zhang, Juren Zhang
Phosphate (Pi) limitation is a constraint for plant growth and development in many natural and agricultural ecosystems. In this study, a gene encoding Zea mays L. protein phosphatase 2A regulatory subunit A, designated ZmPP2AA1, was induced in roots by low Pi availability. The function of the ZmPP2AA1 gene in maize was analyzed using overexpression and RNA interference. ZmPP2AA1 modulated root gravitropism, negatively regulated primary root (PR) growth, and stimulated the development of lateral roots (LRs)...
2017: PloS One
https://www.readbyqxmd.com/read/28447565/risk-factors-for-brain-metastases-in-patients-with-metastatic-colorectal-cancer
#3
Troels Dreier Christensen, Jesper Andreas Palshof, Finn Ole Larsen, Estrid Høgdall, Tim Svenstrup Poulsen, Per Pfeiffer, Benny Vittrup Jensen, Mette Karen Yilmaz, Ib Jarle Christensen, Dorte Nielsen
BACKGROUND: Brain metastases (BM) from colorectal cancer (CRC) are rare, but the incidence is suspected to rise as treatment of metastatic (m) CRC improves. The aim of this study was to identify possible biological and clinical characteristics at initial presentation of mCRC that could predict later risk of developing BM. Furthermore, we wished to estimate the incidence of BM in long-term surviving patients. MATERIAL AND METHODS: We conducted a retrospective study on a Danish multicenter cohort of patients with mCRC who received cetuximab and irinotecan (CetIri) as third-line treatment...
May 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28446071/human-neural-stem-cell-therapy-for-chronic-ischemic-stroke-charting-progress-from-laboratory-to-patients
#4
John D Sinden, Caroline Hicks, Paul Stroemer, Indira Vishnubhatla, Randolph L Corteling
Chronic disability after stroke represents a major unmet neurological need. ReNeuron's development of a human neural stem cell (hNSC) therapy for chronic disability after stroke is progressing through early clinical studies. A Phase I trial has recently been published, showing no safety concerns and some promising signs of efficacy. A single arm Phase II multicenter trial in patients with stable upper limb paresis has recently completed recruitment. The hNSCs administrated are from a manufactured, conditionally immortalized hNSC line (ReNeuron's CTX0E03 or CTX), generated with c-mycERTAM technology...
April 27, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28445376/defining-temporal-hairline-landmarks
#5
Purushottam A Nagarkar, Jonathan Cheng
Brow dermoids are benign pediatric neoplasms. Endoscopic resection requires incisions placed within the temporal hairline, which is often difficult to reliably locate in infants. The authors studied adult and pediatric patients to define the location of the hairline in relationship to simple facial landmarks. Adult and pediatric patients who were seen in preoperative consultation for facial surgical procedures were identified and included in the study. Patients with a history of facial trauma, surgery, or congenital anomalies were excluded...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445200/the-nasal-tip-rotation-flap-for-reconstruction-of-the-lateral-nasal-tip-anterior-ala-and-soft-triangle-the-authors-experience-with-55-patients
#6
Anastasia Benoit, S Tyler Hollmig, Brian C Leach
BACKGROUND: Defects of the lateral nasal tip, anterior ala, and soft triangle subunits lack reconstructive options that are consistently satisfactory. For such defects, the novel anterior-based nasal tip rotation flap provides functional and aesthetic results in a single operative session. OBJECTIVE: To describe the authors' experience with the nasal tip rotation flap, including patient selection and design modifications to enhance aesthetic success. METHODS: An IRB-approved retrospective database review of nasal tip rotation flap repairs was performed at the Medical University of South Carolina and Stanford University Medical Center...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28444840/topas-simulation-of-the-mevion-s250-compact-proton-therapy-unit
#7
Michael Prusator, Salahuddin Ahmad, Yong Chen
As proton therapy becomes increasingly popular, so does the need for Monte Carlo simulation studies involving accurate beam line modeling of proton treatment units. In this study, the 24 beam configurations of the Mevion S250 proton therapy system installed recently at our institution were modeled using the TOolkit for PArticle Simulation (TOPAS) code. Pristine Bragg peak, spread out Bragg peak (SOBP), and lateral beam profile dose distributions were simulated and matched to the measurements taken during commissioning of the unit...
April 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28442218/alignment-of-the-transcriptome-with-individual-variation-in-animals-selectively-bred-for-high-drinking-in-the-dark-hdid
#8
Robert Hitzemann, Denesa Oberbeck, Ovidiu Iancu, Priscila Darakjian, Shannon McWeeney, Stephanie Spence, Jason Schlumbohm, Pamela Metten, John Crabbe
Among animals at risk for excessive ethanol consumption such as the HDID selected mouse lines, there is considerable individual variation in the amount of ethanol consumed and the associated blood ethanol concentrations (BECs). For the HDID lines, this variation occurs even though the residual genetic variation associated with the DID phenotype has been largely exhausted and thus is most likely associated with epigenetic factors. Here we focus on the question of whether the genes associated with individual variation in HDID-1 mice are different from those associated with selection (risk) (Iancu et al...
April 12, 2017: Alcohol
https://www.readbyqxmd.com/read/28440545/cell-reintegration-stray-epithelial-cells-make-their-way-home
#9
REVIEW
Tyler J Wilson, Dan T Bergstralh
Ongoing work shows that misplaced epithelial cells have the capacity to reintegrate back into tissue layers. This movement appears to underlie tissue stability and may also control aspects of tissue structure. A recent study reveals that cell reintegration in at least one tissue, the Drosophila follicular epithelium, is based on adhesion molecules that line lateral cell surfaces. In this article we will review these observations, discuss their implications for epithelial tissue development and maintenance, and identify future directions for study...
April 25, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28439636/kinematic-alignment-is-a-possible-alternative-to-mechanical-alignment-in-total-knee-arthroplasty
#10
Yong Seuk Lee, Stephen M Howell, Ye-Yeon Won, O-Sung Lee, Seung Hoon Lee, Hamed Vahedi, Seow Hui Teo
PURPOSE: A systematic review was conducted to answer the following questions: (1) Does kinematically aligned (KA) total knee arthroplasty (TKA) achieve clinical outcomes comparable to those of mechanically aligned (MA) TKA? (2) How do the limb, knee, and component alignments differ between KA and MA TKA? (3) How is joint line orientation angle (JLOA) changed from the native knee in KA TKA compared to that in MA TKA? METHODS: Nine full-text articles in English that reported the clinical and radiological outcomes of KA TKA were included...
April 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28439277/expression-of-pennisetum-glaucum-eukaryotic-translational-initiation-factor-4a-pgeif4a-confers-improved-drought-salinity-and-oxidative-stress-tolerance-in-groundnut
#11
Tata Santosh Rama Bhadra Rao, Juturu Vijaya Naresh, Palakolanu Sudhakar Reddy, Malireddy K Reddy, Garladinne Mallikarjuna
Eukaryotic translational initiation factor 4A belong to family of helicases, involved in multifunctional activities during stress and non-stress conditions. The eIF4A gene was isolated and cloned from semi-arid cereal crop of Pennisetum glaucum. In present study, the PgeIF4A gene was expressed under the regulation of stress inducible Arabidopsis rd29A promoter in groundnut (cv JL-24) with bar as a selectable marker. The de-embryonated cotyledons were infected with Agrobacterium tumefaciens (LBA4404) carrying rd29A:PgeIF4A construct and generated high frequency of multiple shoots in phosphinothricin medium...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28439169/the-cortical-boundary-line-as-a-guide-for-incisor-re-positioning-with-anterior-segmental-osteotomies
#12
Abraham Vinod Korath, Ratna Padmanabhan, Anantanarayanan Parameswaran
Anterior alveolar anatomical constraints involving presurgical orthodontic incisor repositioning are often unrecognized and overlooked during orthodontic-surgical treatment planning. A clear discrimination of this cortical limitation is invaluable during the planning stage as it permits the consideration of alternative approaches like the anterior maxillary osteotomy for effecting the required incisor movement. A simple reference line termed the "Cortical Boundary Line" is introduced to facilitate the clinical translation of this information and through suitable case illustrations, the construction of the reference line using the conventional lateral cephalometric radiograph and its usefulness as an adjunct in aiding decisions on orthodontic incisor decompensation is highlighted...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28438995/csilsfm-combines-light-sheet-fluorescence-microscopy-and-coherent-structured-illumination-for-a-lateral-resolution-below-100-nm
#13
Bo-Jui Chang, Victor Didier Perez Meza, Ernst H K Stelzer
Light-sheet-based fluorescence microscopy (LSFM) features optical sectioning in the excitation process. It minimizes fluorophore bleaching as well as phototoxic effects and provides a true axial resolution. The detection path resembles properties of conventional fluorescence microscopy. Structured illumination microscopy (SIM) is attractive for superresolution because of its moderate excitation intensity, high acquisition speed, and compatibility with all fluorophores. We introduce SIM to LSFM because the combination pushes the lateral resolution to the physical limit of linear SIM...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28437630/modified-natural-cycle-for-embryo-transfer-using-frozen-thawed-blastocysts-a-satisfactory-option
#14
Quoc V Le, Sina Abhari, Omar M Abuzeid, Jennifer DeAnna, Mohamed A Satti, Tarek Abozaid, Iqbal Khan, Mostafa I Abuzeid
OBJECTIVE: To describe pregnancy outcomes of frozen-thawed blastocysts cycles using modified natural cycle frozen embryo transfers (NC-FET) and down-regulated hormonally controlled frozen embryo transfers (HC-FET) protocols. STUDY DESIGN: This retrospective cohort study included all patients undergoing either modified NC-FET or down-regulated HC-FET using frozen-thawed day 5 embryos. Cycles with donor blastocysts were excluded. Four hundred twenty eight patients underwent a total of 493 FET cycles...
April 6, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28437057/psychotic-and-bipolar-disorders-behavioral-disorders-in-dementia
#15
Sherri Morgan
Psychosis is one of the most common conditions in later life, with dementia being a main contributing factor. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), now categorizes the various types of dementia as neurocognitive disorders. Alzheimer disease is a common cause of dementia and psychosis. Psychosis also is seen in patients with vascular dementia and dementia with Lewy bodies. Psychosis can be primary, caused by a psychiatric disorder listed in the DSM-5, or secondary, due to a medical or neurologic condition...
April 2017: FP Essentials
https://www.readbyqxmd.com/read/28436252/cost-effectiveness-and-safety-of-ramucirumab-plus-paclitaxel-chemotherapy-in-the-treatment-of-advanced-and-recurrent-gastric-cancer
#16
Michio Kimura, Eiseki Usami, Hitomi Teramachi, Tomoaki Yoshimura
Introduction Weekly paclitaxel (PTX), irinotecan (CPT-11) and ramucirumab plus paclitaxel (Ram + PTX) are currently recommended as the standard second-line or later chemotherapies for advanced and recurrent gastric cancer. This study aims to compare the cost-effectiveness of using Ram + PTX vs. PTX or CPT-11. Furthermore, we investigated the safety and treatment continuity of Ram + PTX in Japan. Methods Expected costs were calculated based on data from patients with advanced and recurrent gastric cancer who were treated with PTX, CPT-11 and Ram + PTX...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28433679/part-i-design-synthesis-and-biological-evaluation-of-novel-pyrazole-benzimidazole-conjugates-as-checkpoint-kinase-2-chk2-inhibitors-with-studying-their-activities-alone-and-in-combination-with-genotoxic-drugs
#17
Shadia A Galal, Ahmed S Abdelsamie, Samia A Shouman, Yasmin M Attia, Hamed I Ali, Ashraf Tabll, Reem El-Shenawy, Yasmine S El Abd, Mamdouh M Ali, Abeer E Mahmoud, Abeer H Abdel-Halim, Amal A Fyiad, Adel S Girgis, Hoda I El-Diwani
Activated checkpoint kinase 2 (Chk2) is a tumor suppressor as one of the main enzymes that affect the cell cycle. 2-Biarylbenzimidazoles are potent selective class of Chk2 inhibitors; the structure-based design was applied to synthesize a new series of this class with replacing the lateral aryl group by substituted pyrazoles. Ten pyrazole-benzimidazole conjugates from the best fifty candidates according to docking programs have been subjected to chemical synthesis in this study. The activities of the conjugates 5-14 as checkpoint kinase inhibitors and as antitumor alone and in combination with genotoxic drugs were evaluated...
April 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28432875/one-step-surgical-correction-of-transverse-and-anteroposterior-maxillary-deficiencies-using-wire-fixation-a-new-approach-and-long-term-stability
#18
Max Domingues Pereira, Vivian Farfel, Gabriela Pereira Ribeiro Prado, Lydia Masako Ferreira
PURPOSE: To describe a retrospective assessment of the long-term stability of a new approach using wire fixation for 1-step surgical correction of transverse and anteroposterior maxillary deficiencies. PATIENTS AND METHODS: The authors implemented a case series of 5 adult patients (3 men and 2 women; mean age, 31.4 yr) needing maxillary advancement less than 5 mm and had transverse maxillary deficiency greater than 7 mm who underwent total Le Fort I and median palatal suture osteotomies and had their maxilla advanced and stabilized bilaterally with stainless steel wire...
March 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28432172/why-tuberculosis-control-programmes-fail-role-of-microlevel-and-macrolevel-factors-an-analysis-from-india
#19
Sudip Bhattacharya, Amarjeet Singh
India accounts for one-fourth of the global tuberculosis (TB) burden. The National TB Program was started in 1962. Over a period of time, some lacunae such as poor case detection rate and incomplete treatment were observed. Later, the government formulated the Revised National Tuberculosis Control Program (RNTCP), which achieved a case detection rate of 70% and a cure rate of 85%. Still, the problem of relapse and defaulter cases persists. In 2014, 6% defaulter cases were reported from India. RNTCP has also focused on microlevel aspects, that is, newer diagnostics such as GenXpert, line probe assay and medicines such as bedaquiline for drug-resistant TB...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28428666/linear-short-term-heart-rate-variability-parameters-of-subjects-tobacco-cigarette-smokers-and-subjects-nonsmokers-in-preoperative-period
#20
Meldijana Omerbegovic
BACKGROUND: Variations of heart cycles reflect complex dynamic cardiocirculatory regulatory systems in humans. Exposure to tobacco from cigarettes has been shown to elicit specific alterations of heart rate variability parameters leading to predominance of sympathetic and decreasing parameters of parasympathetic measures of cardiac autonomic nervous system tone. AIM: The aim of the trial was assessing differences of linear parameters of heart rate variability in subjects with habit of consuming of cigarettes tobacco in regard to subjects who are not consumers of tobacco...
February 2017: Medical Archives
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