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https://www.readbyqxmd.com/read/29679784/a-swinging-seesaw-as-a-novel-model-mechanism-for-time-dependent-hormesis-under-dose-dependent-stimulatory-and-inhibitory-effects-a-case-study-on-the-toxicity-of-antibacterial-chemicals-to-aliivibrio-fischeri
#1
Haoyu Sun, Edward J Calabrese, Min Zheng, Dali Wang, Yongzheng Pan, Zhifen Lin, Ying Liu
Hormesis occurs frequently in broadly ranging biological areas (e.g. plant biology, microbiology, biogerontology), toxicology, pharmacology and medicine. While numerous mechanisms (e.g. receptor and pathway mediated pathway responses) account for stimulatory and inhibitory features of hormetic dose responses, the vast majority emphasizes the inclusion of many doses but only one timepoint or use of a single optimized dose that is assessed over a broad range of timepoints. In this paper, a toxicity study was designed using a large number of properly spaced doses with responses determined over a large number of timepoints, which could help us reveal the underlying mechanism of hormesis...
April 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29677189/progress-in-the-pharmacological-treatment-of-human-cystic-and-alveolar-echinococcosis-compounds-and-therapeutic-targets
#2
Mar Siles-Lucas, Adriano Casulli, Roberto Cirilli, David Carmena
Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29677095/milling-the-mistletoe-nanotechnological-conversion-of-african-mistletoe-loranthus-micranthus-intoantimicrobial-materials
#3
Muhammad Sarfraz, Sharoon Griffin, Tamara Gabour Sad, Rama Alhasan, Muhammad Jawad Nasim, Muhammad Irfan Masood, Karl Herbert Schäfer, Chukwunonso E C C Ejike, Cornelia M Keck, Claus Jacob, Azubuike P Ebokaiwe
Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm...
April 20, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29676953/overinduction-of-the-cyp51a-gene-after-exposure-to-azole-antifungals-provides-a-first-clue-to-the-resistance-mechanism-in-the-fusarium-solani-species-complex
#4
Maurine D'Agostino, Thomas Lemmet, Claire Dufay, Amandine Luc, Jean Pol Frippiat, Marie Machouart, Anne Debourgogne
The genus Fusarium is largely represented in fungal infections, not only mostly in plants but also in humans. Fungi belonging to the Fusarium solani species complex (FSSC) are those that are most frequently isolated in invasive fusariosis and present elevated minimum inhibitory concentrations for the main antifungal drugs used in medicine. This study is the first to investigate the resistance mechanism in FSSC by monitoring CYP51A expression in the presence of azole antifungals. After exposure to voriconazole, an overinduction of CYP51A was observed irrespective of the concentration of antifungal used and the generation studied...
April 20, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29676231/combating-neurodegenerative-diseases-with-the-plant-alkaloid-berberine-molecular-mechanisms-and-therapeutic-potential
#5
Dahua Fan, Liping Liu, Zhengzhi Wu, Meiqun Cao
Neurodegenerative diseases are among the most serious health problems affecting millions of people worldwide. Such diseases are characterized by a progressive degeneration and / or death of neurons in the central nervous system. Currently, there are no therapeutic approaches to cure or even halt the progression of neurodegenerative diseases. During the last two decades, much attention has been paid to the neuroprotective and anti-neurodegenerative activities of compounds isolated from natural products with high efficacy and low toxicity...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29676115/-survival-state-and-fruiting-characteristics-of-endangered-medicinal-plant-sinopodophyllum-hexandrum-plant-in-tibet-plateau
#6
Qi-Qiang Guo, Chao Gao, Hui-E Li, Yan-Hui Ye, Yan-Ying Han
This study was carried out by the methods of typical plots investigation and laboratory test aiming at analyzing the survival state and fruiting characteristics of three Sinopodophyllum hexandrum populations in different environmental habitats. Meanwhile, it could provide scientific basis for enhancing wild population quantity recovery. The results showed that more population quantity grow in the habitats of large-area gap (Population A) and bushes (Population C) with a majority of the young individuals, while the minor-area gap (Population B) was the opposite...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676110/-species-diversity-of-ex-situ-cultivated-chinese-medicinal-plants
#7
Ling Que, Xiu-Lian Chi, Chun-Xin Zang, Yu Zhang, Min Chen, Guang Yang, An-Qi Jin
Ex-situ conservation is an important means to protect biological genetic resources. Resource protection has received more and more attention with the continuous improvement of the comprehensive utilization of traditional Chinese medicine resources. In this paper, the research and compilation of the species list of ex-situ cultivated medicinal plants in 12 Chinese Academy of Sciences botanic gardens and 19 specialized medicinal botanic gardens in China were carried out. Based on the Species 2000(2017) and other classification databases, species diversity of medicinal plants ex-situ cultivated in these botanical gardens were analyzed...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676109/-research-actuality-and-quality-influencing-factor-of-epimedii-folium
#8
Ai-Ping Deng, Wen-Tao Fang, Qing-Gang Zhou, Hong-Jun Yang, Ling Wang, Tie-Gui Nan, Li-Ping Kang, Lan-Ping Guo, Lu-Qi Huang, Zhi-Lai Zhan
Epimedii Folium has a long history in China as a common traditional Chinese medicine. Key factors of Epimedii Folium quality were summarized based on ancient literatures, Chinese Pharmacopoeias and modern research in different period of history. The main reason for unqualified Epimedii Folium is unstable icariin. Therefore, it's suggested that: the precondition of the quality control of epimedium is to find the proper quality marker. It's suggested that the medicinal parts should be reverted to "dry whole plant overground" to solve Epimedium resource shortage problem...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676087/-anti-breast-cancer-mechanism-of-flavonoids
#9
REVIEW
Bai-Bing Pang, Yuan-Kui Chu, Hua Yang
Flavonoids are a kind of ubiquitous natural products in plants and essential active ingredients of many medicinal plants. They have the characteristics of broad biological activity, high efficiency and low toxicity, with good prevention and cure effects on various types of tumors. Breast cancer is the commonest cancer disease and the main cause of cancer death in women worldwide. In China, the morbidity and mortality are still on the rise. Flavonoids can inhibit the occurrence and development of breast cancer in various aspects...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676085/-research-progress-of-jasmonate-responsive-transcription-factors-in-regulating-plant-secondary-metabolism
#10
REVIEW
Na Yao, Li Jing, Han Zheng, Min Chen, Ye Shen
Jasmonates, as a plant endogenous hormone, can induce the biosynthesis of terpenoids, alkaloids and flavonoids and other medicinal active ingredients, and play an important role in the plant secondary metabolic process. The tanscription factors can activate the expression of multiple genes in the biosynthesis of plant secondary metabolites by binding the cis-elements of the target genes. Then, it effectively activates or inhibits the activities of the enzymes on the biosynthesis of plant secondary metabolites, further regulate specific biosynthesis and accumulation of secondary metabolites...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675816/brc4env-a-network-of-biological-resource-centres-for-research-in-environmental-and-agricultural-sciences
#11
Christian Mougin, Emmanuelle Artige, Frédéric Marchand, Samuel Mondy, Céline Ratié, Nadine Sellier, Philippe Castagnone-Sereno, Armelle Cœur D'Acier, Daniel Esmenjaud, Céline Faivre-Primot, Laurent Granjon, Valérie Hamelet, Frederic Lange, Sylvie Pagès, Frédéric Rimet, Nicolas Ris, Guillaume Sallé
The Biological Resource Centre for the Environment BRC4Env is a network of Biological Resource Centres (BRCs) and collections whose leading objectives are to improve the visibility of genetic and biological resources maintained by its BRCs and collections and to facilitate their use by a large research community, from agriculture research to life sciences and environmental sciences. Its added value relies on sharing skills, harmonizing practices, triggering projects in comparative biology, and ultimately proposing a single-entry portal to facilitate access to documented samples, taking into account the partnership policies of research institutions as well as the legal frame which varies with the biological nature of resources...
April 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29675436/prevention-and-treatment-of-osteoporosis-using-chinese-medicinal-plants-special-emphasis-on-mechanisms-of-immune-modulation
#12
REVIEW
Hongyan Zhao, Ning Zhao, Peng Zheng, Xiaohong Xu, Meijie Liu, Dan Luo, Huihui Xu, Dahong Ju
Numerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. Recent osteoimmunology studies demonstrated that the immune system and immune factors play important regulatory roles in the occurrence of osteoporosis, and people should pay more attention to the relationship between immunity and osteoporosis. Immune and bone cells are located in the bone marrow and share numerous regulatory molecules, signaling molecules, and transcription factors...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29675050/analgesic-and-anti-inflammatory-effects-of-80-methanol-extract-of-leonotis-ocymifolia-burm-f-iwarsson-leaves-in-rodent-models
#13
Asnakech Alemu, Wondmagegn Tamiru, Teshome Nedi, Workineh Shibeshi
Background: Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants. Leonotis ocymifolia is one of such medicinal plants used in folkloric medicine of Ethiopia. However, the plant has not been scientifically evaluated. The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of Leonotis ocymifolia using rodent models. Method: The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29674964/botanical-provenance-of-traditional-medicines-from-carpathian-mountains-at-the-ukrainian-polish-border
#14
REVIEW
Weronika Kozlowska, Charles Wagner, Erin M Moore, Adam Matkowski, Slavko Komarnytsky
Plants were an essential part of foraging for food and health, and for centuries remained the only medicines available to people from the remote mountain regions. Their correct botanical provenance is an essential basis for understanding the ethnic cultures, as well as for chemical identification of the novel bioactive molecules with therapeutic effects. This work describes the use of herbal medicines in the Beskid mountain ranges located south of Krakow and Lviv, two influential medieval centers of apothecary tradition in the region...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29674043/-1-h-nmr-and-antioxidant-profiles-of-polar-and-non-polar-extracts-of-persimmon-diospyros-kaki-l-metabolomics-study-based-on-cultivars-and-origins
#15
M Maulidiani, Ahmed Mediani, Faridah Abas, Yong Seo Park, Yang-Kyun Park, Young Mo Kim, Shela Gorinstein
Persimmon (Diospyros kaki L.) is one of the most important fruits that has been consumed for its medicinal properties due to the presence of some active metabolites, particularly polyphenols and carotenoids. Previously described methods, including HPLC, were limited in the determination of metabolites in different persimmon varieties. The present study shows the evaluation and the differences among persimmon polar and non-polar extracts by 1 H NMR-based metabolomics approach. The hierarchical clustering analysis (HCA) based on score values of principal component analysis (PCA) model was used to analyze the important compounds in investigated fruits...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673553/the-discoveries-of-molecular-mechanisms-for-the-circadian-rhythm-the-2017-nobel-prize-in-physiology-or-medicine
#16
Rong-Chi Huang
Circadian clocks evolved to allow plants and animals to adapt their behaviors to the 24-hr change in the external environment due to the Earth's rotation. While the first scientific observation of circadian rhythm in the plant leaf movement may be dated back to the early 18th century, it took 200 years to realize that the leaf movement is controlled by an endogenous circadian clock. The cloning and characterization of the first Drosophila clock gene period in the early 1980s, independently by Jeffery C. Hall and Michael Rosbash at Brandeis University and Michael Young at Rockefeller University, paved the way for their further discoveries of additional genes and proteins, culminating in establishing the so-called transcriptional translational feedback loop (TTFL) model for the generation of autonomous oscillator with a period of ∼24 h...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29672820/a-review-of-the-toxicity-of-compounds-found-in-herbal-dietary-supplements
#17
Amy Hudson, Elizabeth Lopez, Ahmad J Almalki, Amy L Roe, Angela I Calderón
Use of herbal dietary supplements by the public is common and has been happening for centuries. In the United States, the Food and Drug Administration has a limited scope of regulation over marketed herbal dietary supplements, which may contain toxic botanical compounds that pose a public health risk. While the Food and Drug Administration has made efforts to prohibit the sale of unsafe herbal dietary supplements, numerous reports have proliferated of adverse events due to these supplements. This literature review investigates bioactive plant compounds commonly used in herbal dietary supplements and their relative toxicities...
April 19, 2018: Planta Medica
https://www.readbyqxmd.com/read/29672819/isolation-and-determination-of-phenolic-glycosides-and-anthraquinones-from-rhizomes-of-various-reynoutria-species
#18
Izabela Nawrot-Hadzik, Sebastian Granica, Krzysztof Domaradzki, Łukasz Pecio, Adam Matkowski
Giant knotweeds of the genus Reynoutria (syn. Fallopia )- Reynoutria japonica, Reynoutria sachalinensis , and a hybrid of them, Reynoutria x bohemica -are noxious invasive plants in Europe and North America. R. japonica is a traditional East Asian (Japan and China) drug ( Polygoni cuspidati rhizoma ). Recently, it has been included in European Pharmacopoeia as one of the traditional Chinese medicinal herbs. In this study, a reversed-phase high performance liquid chromatography method with diode array detector and time-of-flight mass spectrometry was developed and validated for the profiling of rhizomes from European invasive populations and Polygoni cuspidati rhizoma purchased in China...
April 19, 2018: Planta Medica
https://www.readbyqxmd.com/read/29672818/the-in-vitro-and-in-vivo-effects-of-hypoxis-hemerocallidea-on-indinavir-pharmacokinetics-modulation-of-efflux
#19
Kaylee Havenga, Efrem Abay, Lubbe Wiesner, Alvaro Viljoen, Dewald Steyn, Josias Hamman
Hypoxis hemerocallidea (African potato) is a popular medicinal plant that has been used traditionally for the treatment of various disorders. Some HIV/AIDS patients use this traditional medicine together with their antiretroviral therapy. This study aimed to determine the impact of selected H. hemerocallidea materials (i.e., a commercial product, an aqueous extract, and biomass reference plant material) on the bidirectional permeability of indinavir across Caco-2 cell monolayers as well as the bioavailability of indinavir during an acute, single administration study in Sprague-Dawley rats...
April 19, 2018: Planta Medica
https://www.readbyqxmd.com/read/29671239/ethnobotanical-knowledge-of-pastoral-community-for-treating-livestock-diseases-in-somali-regional-state-eastern-ethiopia
#20
Ewonetu Kebede, Melese Mengistu, Biresaw Serda
Modern livestock health care is still at its lowest stage in Ethiopia and most modern veterinary services like drugs and veterinary professionals are not accessible and affordable to the majority of pastoral farmers. As a result, they rely on their traditional knowledge and practices on locally available. However, this traditional knowledge has not yet been well documented. Therefore, this study identified medicinal plants used in treating animal diseases and examined factors that threatens ethno-veterinary in pastoral community of Shinle Districts...
April 18, 2018: Tropical Animal Health and Production
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