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https://www.readbyqxmd.com/read/29458147/sessein-and-isosessein-with-anti-inflammatory-antibacterial-and-antioxidant-activity-isolated-from-salvia-sessei-benth
#1
Abraham Gómez-Rivera, Manasés González-Cortazar, Maribel Herrera-Ruíz, Alejandro Zamilpa, Verónica Rodríguez-López
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia sessei Benth, popularly known as "pipilolxochitl" or "sabanito", is a plant utilized in Mexico in traditional medicine for the treatment of erysipela. To date, only one report, to our knowledge, has been found in which a royleanone-type diterpene of the aerial parts of the species was isolated but, again to our knowledge, studies have not been conducted on the pharmacological activity of extracts and compounds isolated from this plant...
February 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29456393/-in-vitro-h-k-atpase-inhibition-antiradical-effects-of-a-flavonoid-rich-fraction-of-dissotis-rotundifolia-and-in-silico-pass-prediction-of-its-isolated-compounds
#2
Michael Buenor Adinortey, Charles Ansah, Cynthia Ayefoumi Adinortey, Justine McGiboney, Alexander Nyarko
Background: Dissotis rotundifolia , commonly referred to as pink lady, has several medicinal uses including peptic ulcer. This study investigated the inhibitory effects of D. rotundifolia extract on H+ /K+ -ATPase and also assessed its antiradical activity. In silico study of some isolated compounds of this plant was also carried out to affirm the suspected binding properties of extract to H+ /K+ -ATPase enzyme. Materials and Methods: D. rotundifolia whole plant extract was obtained after extraction process and then assessed for its ability to scavenge free radicals in four in vitro test models...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456380/moxibustion-artemisia-plant-at-acupuncture-point-as-alternative-therapy-in-hypertension-a-promising-approach
#3
Mohammad Jamshed Siddiqui, Mohamad Fadly Bin Kamarudin, Abdul Kareem Mohammed Al-Shami, Siti Zaiton Mat So'ad, Shazia Qasim Jamshed
Hypertension is a pathological condition in which the blood pressure is higher than under normal physiological conditions, i.e., 140/90 mmHg or higher. Blood pressure is measured as the force exerted by the blood pumped by the heart against the walls of arteries (aorta) and distributed throughout the body. Use of complementary and alternative medicine as a cure for hypertension is a common phenomenon because of the high risk of cardiovascular complications and kidney diseases caused by conventional Western medicine...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29455337/arbuscular-mycorrhiza-facilitates-the-accumulation-of-glycyrrhizin-and-liquiritin-in-glycyrrhiza-uralensis-under-drought-stress
#4
Wei Xie, Zhipeng Hao, Xiaofu Zhou, Xuelian Jiang, Lijiao Xu, Songlin Wu, Aihua Zhao, Xin Zhang, Baodong Chen
Liquorice (Glycyrrhiza uralensis) is an important medicinal plant for which there is a huge market demand. It has been reported that arbuscular mycorrhizal (AM) symbiosis and drought stress can stimulate the accumulation of the active ingredients, glycyrrhizin and liquiritin, in liquorice plants, but the potential interactions of AM symbiosis and drought stress remain largely unknown. In the present work, we investigated mycorrhizal effects on plant growth and accumulation of glycyrrhizin and liquiritin in liquorice plants under different water regimes...
February 17, 2018: Mycorrhiza
https://www.readbyqxmd.com/read/29454914/substituting-one-paris-for-another-in-vitro-cytotoxic-and-in-vivo-antitumor-activities-of-paris-forrestii-a-substitute-of-paris-polyphylla-var-yunnanensis
#5
Yue-Hu Wang, Min Shi, Hong-Mei Niu, Jun Yang, Meng-Yuan Xia, Ji-Feng Luo, Ying-Jie Chen, Yi-Ping Zhou, Heng Li
ETHNOPHARMACOLOGICAL RELEVANCE: Chong-lou (Paris polyphylla var. yunnanensis or P. polyphylla var. chinensis) is traditionally used as an anticancer medicine in China. It is also the material basis of some Chinese patent anticancer medicines, such as Gan-Fu-Le capsules, Bo-Er-Ning capsules, Lou-Lian capsules, Ruan-Jian oral liquid, and Qi-Zhen capsules. P. forrestii, a substitute for Chong-lou, is planted at a large scale in the Yunnan Province of China. AIM OF THE STUDY: To clarify the active chemical constituents of P...
February 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29454617/antihypertensive-potential-of-linalool-and-linalool-complexed-with-%C3%AE-cyclodextrin-effects-of-subchronic-treatment-on-blood-pressure-and-vascular-reactivity
#6
Samuel Barbosa Camargo, Letícia Oliveira Simões, Carla Fiama de Azevedo Medeiros, Anderson de Melo Jesus, Josmara Bartolomei Fregoneze, Afrânio Evangelista, Cristiane Flora Villarreal, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Darizy Flavia Silva
Linalool (LIN) is a monoterpene alcohol present in some aromatic medicinal plants with biological activities that can impact cardiovascular diseases. This chemical class is highly volatile and β-cyclodextrin (β-CD) has been employed to improve the pharmacological properties of monoterpenes. Thus, the aim of this study was to evaluate the cardiovascular effects of LIN free focusing on the antihypertensive properties of this monoterpene and to study whether LIN, complexed in β-cyclodextrin (LIN-βCD) is able to improve the pharmacological activity of LIN...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29453917/comparative-chemical-investigation-and-evaluation-of-antioxidant-and-tyrosinase-inhibitory-effects-of-withania-somnifera-l-dunal-and-solanum-nigrum-l-berries
#7
Abdul Hameed, Naveed Akhtar
In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453255/endophyte-mediated-modulation-of-defense-responsive-genes-and-systemic-resistance-in-withania-somnifera-l-dunal-under-alternaria-alternata-stress
#8
Aradhana Mishra, Satyendra Pratap Singh, Sahil Mahfooz, Surendra Pratap Singh, Arpita Bhattacharya, Nishtha Mishra, C S Nautiyal
Endophytes have been explored to perform an important role in plant health. However, their effects on the host physiological function and disease management remains elusive. The present study was aimed to assess the potential of endophytes singly as well as in combination on various physiological parameters and systemic defense mechanism against Alternaria alternata in Withania somnifera (L.) Dunal. Seed priming with endophytic Bacillus amyloliquefaciens and Pseudomonas fluorescens individually and in combination demonstrated enhanced vigor index and germination rate...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29453086/pegylated-polyaminoacid-capped-mesoporous-silica-nanoparticles-for-mitochondria-targeted-delivery-of-celastrol-in-solid-tumors
#9
Ju Yeon Choi, Biki Gupta, Thiruganesh Ramasamy, Jee-Heon Jeong, Sung Giu Jin, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
The major goal of cancer chemotherapy is to maximize the therapeutic efficacy of anticancer drugs, while minimizing their associated side effects. Celastrol (CST), which is extracted from the traditional Chinese medicinal plant Tripterygium wilfordii, has been reported to exhibit significant anticancer effects in various in vitro and in vivo cancer models. Nanoparticulate drug delivery systems could be employed to preserve and enhance the pharmacological effects of CST in cancer cells. Among these, mesoporous silica nanoparticles (MSNs) are one of the most promising drug delivery systems...
February 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29452960/traditionally-practiced-medicinal-plant-extracts-inhibit-the-ergosterol-biosynthesis-of-clinically-isolated-dermatophytic-pathogens
#10
M Chellappandian, M Saravanan, P Pandikumar, P Harikrishnan, K Thirugnanasambantham, S Subramanian, V I Hairul-Islam, S Ignacimuthu
OBJECTIVE: Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, India. MATERIALS AND METHODS: Selected plant parts were collected, shade dried and powdered. Plant powders were extracted with ethanol and their antifungal potency was investigated against and clinical dermatophytes...
February 13, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29452141/a-rich-source-of-potential-bioactive-compounds-with-anticancer-activities-by-catharanthus-roseus-cambium-meristematic-stem-cell-cultures
#11
So Hyun Moon, Muthuraman Pandurangan, Doo Hwan Kim, Jelli Venkatesh, Rahul V Patel, Bhupendra M Mistry
ETHNOPHARMACOLOGICAL IMPORTANCE: Catharanthus roseus (L.) G. Don. is an important medicinal plant with rich sources of remarkable health benefits consisting more than 100 alkaloids and significant amounts of bioactive compounds, which have been widely used as a folk medicine for treatment of several pathologies. THE AIM OF THE STUDY: In the present study, we isolated and cultured innately undifferentiated cambium meristematic cells (CMCs), which were observed stable cell growth, enhancement of bioactive compounds from C...
February 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29451901/the-novel-antibiotic-rhodomyrtone-traps-membrane-proteins-in-vesicles-with-increased-fluidity
#12
Dennapa Saeloh, Varomyalin Tipmanee, Kin Ki Jim, Marien P Dekker, Wilbert Bitter, Supayang P Voravuthikunchai, Michaela Wenzel, Leendert W Hamoen
The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinical applications, very little is known about the mechanism of action of rhodomyrtone. Preceding studies have been focused on intracellular targets, but no specific intracellular protein could be confirmed as main target. Using live cell, high-resolution, and electron microscopy we demonstrate that rhodomyrtone causes large membrane invaginations with a dramatic increase in fluidity, which attract a broad range of membrane proteins...
February 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29451882/de-novo-transcriptomic-analysis-of-leaf-and-fruit-tissue-of-cornus-officinalis-using-illumina-platform
#13
Dian-Yun Hou, Lin-Chun Shi, Meng-Meng Yang, Jiong Li, Shuang Zhou, Hong-Xiao Zhang, Hua-Wei Xu
Cornus officinalis is one of the most widely used medicinal plants in China and other East Asian countries to cure diseases such as liver, kidney, cardiovascular diseases and frequent urination for thousands of years. It is a Level 3 protected species, and is one of the 42 national key protected wild species of animals and plants in China. However, the genetics and molecular biology of C. officinalis are poorly understood, which has hindered research on the molecular mechanism of its metabolism and utilization...
2018: PloS One
https://www.readbyqxmd.com/read/29449878/complete-chloroplast-genome-of-the-medicinal-plant-amomum-compactum-gene-organization-comparative-analysis-and-phylogenetic-relationships-within-zingiberales
#14
Ming-Li Wu, Qing Li, Jiang Xu, Xi-Wen Li
Background: Amomum compactum is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position of A. compactum is not clear yet, and the introduction of this plant has been hindered by many plant diseases. However, the correlational molecular studies are relatively scarce. Methods: The total chloroplast (cp) DNA was extracted according to previous studies, and then sequenced by 454 GS FLX Titanium platform...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449876/authenticity-analyses-of-rhizoma-paridis-using-barcoding-coupled-with-high-resolution-melting-bar-hrm-analysis-to-control-its-quality-for-medicinal-plant-product
#15
Bao-Zhong Duan, Ya-Ping Wang, Hai-Lan Fang, Chao Xiong, Xi-Wen Li, Ping Wang, Shi-Lin Chen
Background: Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. and Paris polyphylla Smith var . chinensis (Franch.) Hara are the two main sources of Chonglou under the monograph of Rhizoma Paridis in Chinese Pharmacopoeia. In the local marketplace, however, this medicine is prone to be accidentally contaminated, deliberately substituted or admixed with other species that are similar to Rhizoma Paridis in shape and color...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449808/suppressive-effects-of-clerodendrum-volubile-p-beauv-labiatae-methanolic-extract-and-its-fractions-on-type-2-diabetes-and-its-complications
#16
Ochuko L Erukainure, Rahman M Hafizur, Nurul Kabir, M Iqbal Choudhary, Olubunmi Atolani, Priyanka Banerjee, Robert Preissner, Chika I Chukwuma, Aliyu Muhammad, Eric O Amonsou, Md Shahidul Islam
Type 2 diabetes is the most prominent of all diabetes types, contributing to global morbidity and mortality. Availability and cost of treatment with little or no side effect especially in developing countries, remains a huge burden. This has led to the search of affordable alternative therapies especially from medicinal plants. In this study, the antidiabetic effect of the methanolic extract, dichloromethane (DCM), butanol (BuOH) and aqueous fractions of Clerodendrum volubile leaves were investigated in type 2 diabetic rats for their effect on glucose homeostasis, serum insulin level and hepatic biomarkers, lipid profile, pancreatic redox balance and Ca 2+ levels, and β-cell distribution and function...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29449610/phaeophleospora-vochysiae-savi-glienke-sp-nov-isolated-from-vochysia-divergens-found-in-the-pantanal-brazil-produces-bioactive-secondary-metabolites
#17
Daiani C Savi, Khaled A Shaaban, Francielly Maria Wilke Ramos Gos, Larissa V Ponomareva, Jon S Thorson, Chirlei Glienke, Jürgen Rohr
Microorganisms associated with plants are highly diverse and can produce a large number of secondary metabolites, with antimicrobial, anti-parasitic and cytotoxic activities. We are particularly interested in exploring endophytes from medicinal plants found in the Pantanal, a unique and widely unexplored wetland in Brazil. In a bio-prospecting study, strains LGMF1213 and LGMF1215 were isolated as endophytes from Vochysia divergens, and by morphological and molecular phylogenetic analyses were characterized as Phaeophleospora vochysiae sp...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448941/traditional-healing-practices-in-rural-bangladesh-a-qualitative-investigation
#18
Md Imdadul Haque, A B M Alauddin Chowdhury, Md Shahjahan, Md Golam Dostogir Harun
BACKGROUND: Traditional healing practice is an important and integral part of healthcare systems in almost all countries of the world. Very few studies have addressed the holistic scenario of traditional healing practices in Bangladesh, although these serve around 80% of the ailing people. This study explored distinctive forms of traditional healing practices in rural Bangladesh. METHODS: During July to October 2007, the study team conducted 64 unstructured interviews, and 18 key informant interviews with traditional healers and patients from Bhabanipur and Jobra, two adjacent villages in Chittagong district, Bangladesh...
February 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29448811/production-of-a-new-mucilage-compound-in-lepidium-sativum-callus-by-optimizing-in-vitro-growth-conditions
#19
Pooran Golkar, Fatemeh Hadian, Mehrana Koohi Dehkordi
The mucilage in Lepidium sativum L. is considered a biologically active compound with diverse medicinal properties. Different explants (hypocotyls and leaf) were transferred to Murashige and Skoog (MS) medium supplemented with twelve different plant growth regulator combinations under two different incubations (light and dark). The best mucilage production from callus (36.76% g g -1 dry weight) was obtained in the MS medium supplemented with 1 mg L -1 of 2, 4-D and 2 mg L -1 of BAP under the light condition...
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29447984/salicin-7-sulfate-a-new-salicinoid-from-willow-and-implications-for-herbal-medicine
#20
Clarice Noleto-Dias, Jane L Ward, Alice Bellisai, Charlotte Lomax, Michael H Beale
Willow (Salix sp.) is a historically well-known herbal medicine that provided the lead compound (salicin) for the discovery of aspirin, one of the most successful plant derived drugs in human medicine. During a metabolomics screen of 86 Salix species contained in the UK National Willow Collection, we have discovered, isolated and fully characterised a new natural salicinoid - salicin-7-sulfate. This molecule may have important human pharmacological actions that need to be considered in determining the efficacy and safety of willow herbal medicines...
February 12, 2018: Fitoterapia
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