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https://www.readbyqxmd.com/read/29935346/ethnopharmacology-phytochemistry-and-pharmacology-of-chinese-salvia-species-a-review
#1
REVIEW
Xu Jianping, Wei Kunhua, Zhang Guojun, Lei Lujing, Yang Dawei, Wang Wenle, Han Qiheng, Xia Yuan, Bi Yaqiong, Yang Min, Li Minhui
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Salvia is one of the largest genera of the Lamiaceae family. In China, about 40 Salvia species have been used as medicinal plants for treatment of various diseases, specifically hepatic and renal diseases and those of the cardiovascular and immune systems. AIM OF THIS REVIEW: This review aims to provide systematically organized information on the ethnopharmacology, phytochemistry, pharmacology, and toxicology of medicinal Salvia species in China to support their therapeutic potential in the treatment of human diseases...
June 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29934731/medicinal-plant-using-ground-state-stabilization-of-natural-antioxidant-curcumin-by-keto-enol-tautomerisation
#2
S Manimaran, K SambathKumar, R Gayathri, K Raja, N Rajkamal, M Venkatachalapathy, G Ravichandran, C Lourdu EdisonRaj
Curcumin is a medicinal agent that exhibits anti-cancer properties and bioactive pigment in Turmeric has a huge therapeutic value. It has a keto-enol moiety that gives rise to many of its chemical properties. A recent study has shown that keto-enol tautomerisation at this moiety is implicated the effect of curcumin. The tautomerisation of curcumin in methanol, acetone and acetonitrile are used in nuclear magnetic resonance (1 H, 13 C) spectroscopy. It was characterized using UV, IR and Raman spectral values...
June 22, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29934653/quorum-sensing-inhibitory-activity-of-the-metabolome-from-endophytic-kwoniella-sp-py016-characterization-and-hybrid-model-based-optimization
#3
Abhirup Mookherjee, Ramalingam Dineshkumar, Nithya N Kutty, Tarun Agarwal, Ramkrishna Sen, Adinpunya Mitra, Tapas Kumar Maiti, Mrinal Kumar Maiti
Quorum sensing, the microbial communication system, is gaining importance as a therapeutic target against pathogens. The two key reasons for the rising demand of quorum sensing (QS) inhibitory molecules are low selective pressure to develop resistance by pathogens and possibility of more species-specific effects. Due to complex interactions in a unique niche of live plant tissues, endophytes, as a survival mechanism, potentially produce various bioactive compounds such as QS inhibitors. We report the isolation of an endophytic fungus Kwoniella sp...
June 22, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29933667/-correlation-analysis-between-cold-and-heat-property-of-traditional-chinese-medicines-and-light-conditions-of-their-original-plants-in-habitat
#4
Hong-Zhuan Shi, Xiao-Lu Yan, Qiao-Sheng Guo, Pan-Pan Chen, Tao Wang
The current study was conducted to explore the relationship between property of traditional Chinese medicines (TCM) and the light conditions of their original plant in habitats and advance a "light-cold and heat property" hypothesis under the guidance of theory of TCM. In the present study, we selected 127 common Chinese herbs. Association rules mining method was used to find out the association relationship between the cold-heat properties of different TCM and the habitats of their original plant, while using statistical methods to analyze the correlation between light condition and cold-heat property of TCM based on the description of the habitats in the Flora of China and investigation...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29933657/-research-advances-on-chemical-constituents-from-calycanthaceae-plants-and-their-pharmacological-activities
#5
REVIEW
Jin-Biao Xu, Jun-Jie Pan, Qun-Dan Lyu, Ke-Jun Cheng
Calycanthaceae family comprises of four genera including Chimonanthus, Sinocalycanthus, Calycanthus, and Idiospermum. The plants of Calycanthaceae are popular ornamental shrubs and used as foods and medicines, which are mainly distributed in China, North America, and Australia. The plants of Calycanthaceae are rich in volatile components, alkaloids, sesquiterpenes and coumarins. Dimeric piperidinoquinoline and dimeric pyrrolidinoindoline alkaloids, dimeric and/or trimeric coumarins are characteristic compositions in these plants...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29933591/chemical-profiling-and-screening-of-the-marker-components-in-the-fruit-of-cassia-fistula-by-hplc-and-uhplc-ltq-orbitrap-ms-n-with-chemometrics
#6
Jiawei Tan, Mengcheng Zheng, Susu Duan, Yanling Zeng, Ziwei Zhang, Qingyu Cui, Jiamei Zhang, Tingting Hong, Jie Bai, Shouying Du
Cassia fistula L. which is known as “Golden Shower”, is used as an ornamental plant due to its flowers, and fruit parts of this plant have a high medicinal value. There are few reports providing a comprehensive overview of the chemical composition of its fruit or explaining the differences between samples from different sources because of the complexity of its chemical components. The purpose of the present study was to establish a fingerprint evaluation system based on Similarity Analysis (SA), Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA) for the composition identification and quality control of this herb...
June 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29933016/potential-therapeutic-applications-of-the-genus-annona-local-and-traditional-uses-and-pharmacology
#7
REVIEW
A M Quílez, M A Fernández-Arche, M D García-Giménez, R De la Puerta
ETHNO-PHARMACOLOGICAL RELEVANCE: Annona species (Annonaceae) have long been used as traditional herbal medicines by native peoples in tropical areas. In different countries they are used against a large variety of illnesses, such as parasitic and infectious diseases, cancer, diabetes, peptic ulcers, and mental disorders. AIM OF THE STUDY: This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29933012/bioassay-guided-isolation-of-active-substances-from-semen-torreyae-identifies-two-new-anthelmintic-compounds-with-novel-mechanism-of-action
#8
Maoxuan Liu, Cedrick Veryser, Jing-Guang Lu, Tom Wenseleers, Wim M De Borggraeve, Zhi-Hong Jiang, Walter Luyten
ETHNOPHARMACOLOGICAL RELEVANCE: Semen Torreyae, the seeds of Torreya grandis Fortune ex Lindley (Cephalotaxaceae) is a well-known traditional Chinese medicinal plant recorded in the Chinese Pharmacopeia (2010 version). It is widely used for treating intestinal parasites in China, owing to its desirable efficacy and safety. However, the anthelmintic compounds in Semen Torreyae have not yet been identified. AIM OF THE STUDY: This study aims to identify the compounds active against helminths from Semen Torreyae...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29933011/the-rise-of-medicalization-of-plants-in-brazil-a-temporal-perspective-on-vernacular-names
#9
Bruno V L Siqueira, Cássia M Sakuragui, Bruno E Soares, Danilo R de Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Brazilian plant species used in folk medicine have acquired several popular names related to commercial medicines in recent decades. This fact has directly effect to the medicalization process. AIM OF THE STUDY: Evaluate the rise of medicalized popular names of medicinal plants in Brazil. MATERIALS AND METHODS: Medicalized popular names of medicinal plants were recorded from 273 ethnobotanical articles in eleven scientific journals published between 1980 and 2017...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29932657/chemical-constituents-of-apios-americana-tubers-and-their-inhibitory-activities-on-nitric-oxide-production-in-lipopolysaccharide-stimulated-raw-264-7-macrophages
#10
Young Hye Seo, Ju-Hyun Jeon, Miran Jeong, Seung Mok Ryu, Won Kyung Jeon, Dae Sik Jang, Sang Hee Shim, Dongho Lee, Jung-Hye Choi, Jun Lee
Apios americana is an important food crop producing edible tubers with high nutritional and medicinal values and is widely cultivated in many countries. Despite its usefulness, research on its secondary metabolites and biological activities has been limited. In the present study, a new coumaronochromone, (2 R,3 S)-3,7,4'-trihydroxy-5-methoxycoumaronochromone (1), and two new isoflavone glucosides, 7,2',4'-trihydroxy-5-methoxyisoflavone-4'- O-β-d-glucopyranoside (3) and 5,7,4'-trihydroxyisoflavone-7- O-β-d-gentiotrioside (5), were isolated from the tubers of A...
June 22, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29932194/quality-assessment-of-penthorum-chinense-pursh-through-multicomponent-qualification-and-fingerprint-chemometric-and-antihepatocarcinoma-analyses
#11
Zong-Liang Sun, Yu-Zhen Zhang, Feng Zhang, Jia-Wei Zhang, Guo-Can Zheng, Ling Tan, Chong-Zhi Wang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
An efficient method combined with fingerprint and chemometric analyses was developed to evaluate the quality of the traditional Chinese medicine plant Penthorum chinense Pursh. Nine samples were collected from different regions during different harvest periods, and 17 components in the form of extracts were simultaneously examined to assess quality by using high-performance liquid chromatography. The hepatoprotective effects of components were investigated by assessing the inhibition of SMMC-7721 cell growth...
June 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29932143/a-balanced-risk-benefit-analysis-to-determine-human-risks-associated-with-pyrrolizidine-alkaloids-pa-the-case-of-herbal-medicinal-products-containing-st-john-s-wort-extracts-sjw
#12
REVIEW
Michael Habs, Karin Binder, Stefan Krauss, Karolina Müller, Brigitte Ernst, Luzia Valentini, Michael Koller
OBJECTIVES: Pyrrolizidine alkaloids (PA) exist ubiquitously in our environment. More than 6000 plants, about 3% of the world’s flowering plants, are known to synthesize PA. As a consequence, many herbal ingredients, including St. John’s wort (SJW), are contaminated with PA that can possess acute and subchronic toxic effects as well as mutagenic and genotoxic properties. Therefore, the possible benefits of SJW as an herbal remedy against depression need to be weighed against the possible risks of unwanted PA intake...
June 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29932034/clinical-use-of-toxic-proteins-and-peptides-from-tian-hua-fen-and-scorpion-venom
#13
Chen Ling, Yuanhui Zhang, Jun Li, Wenli Chen, Changquan Ling
Traditional Chinese Medicine (TCM) has been practiced in China for thousands of years. As a complementary and alternative treatment, herbal medicines that are frequently used in the TCM are the most accepted in the Western world. However, animal materials, which are equally important in the TCM practice, are not well-known in other countries. On the other hand, the Chinese doctors had documented the toxic profiles of hundreds of animals and plants thousand years ago. Furthermore, they saw the potential benefits of these materials and used their toxic properties to treat a wide variety of diseases, such as heavy pain and cancer...
June 21, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29932016/utilization-of-struvite-recovered-from-high-strength-ammonium-containing-simulated-wastewater-as-slow-release-fertilizer-and-fire-retardant-barrier
#14
Kaan Yetilmezsoy, Emel Kocak, Havva Melda Akbin, Didem Özçimen
Sustainable uses of the struvite (magnesium ammonium phosphate hexahydrate, MgNH4 PO4 ·6H2 O, MAP) recovered from the synthetic wastewater, as a high-quality slow-release fertilizer for the growth of nine medicinal plants and a fire-retardant barrier on the flammability of cotton fabric and wooden plate, were explored in this study. The previous experimental results demonstrated that under the optimal conditions, about 98.7% of NH4 + -N (initial NH4 + -N = 1000 mg/L) could be effectively and successfully recovered from simulated wastewater in the form of MAP precipitate...
June 22, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29931585/euphol-a-tetracyclic-triterpene-from-euphorbia-tirucalli-induces-autophagy-and-sensitizes-temozolomide-cytotoxicity-on-glioblastoma-cells
#15
Viviane A O Silva, Marcela N Rosa, Vera Miranda-Gonçalves, Angela M Costa, Aline Tansini, Adriane F Evangelista, Olga Martinho, Adriana C Carloni, Chris Jones, João Paulo Lima, Luiz F Pianowski, Rui Manuel Reis
Glioblastoma (GBM) is the most frequent and aggressive type of brain tumor. There are limited therapeutic options for GBM so that new and effective agents are urgently needed. Euphol is a tetracyclic triterpene alcohol, and it is the main constituent of the sap of the medicinal plant Euphorbia tirucalli. We previously identified anti-cancer activity in euphol based on the cytotoxicity screening of 73 human cancer cells. We now expand the toxicological screening of the inhibitory effect and bioactivity of euphol using two additional glioma primary cultures...
June 22, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29929980/an-n-methyltransferase-from-ephedra-sinica-catalyzing-the-formation-of-ephedrine-and-pseudoephedrine-enables-microbial-phenylalkylamine-production
#16
Jeremy S Morris, Ryan A Groves, Jillian M Hagel, Peter J Facchini
Phenylalkylamines, such as the plant compounds ephedrine and pseudoephedrine and the animal neurotransmitters dopamine and adrenaline, compose a large class of natural and synthetic molecules with important physiological functions and pharmaceutically valuable bioactivities. The final steps of ephedrine and pseudoephedrine biosynthesis in members of the plant genus Ephedra involve N -methylation of norephedrine and norpseudoephedrine, respectively. Here, using a plant transcriptome screen, we report the isolation and characterization of an N -methyltransferase (NMT) from Ephedra sinica able to catalyze the formation of (pseudo)ephedrine and other naturally occurring phenylalkylamines, including N -methylcathinone and N -methyl(pseudo)ephedrine...
June 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29929299/occurrence-and-ecotoxicological-assessment-of-pharmaceuticals-is-there-a-risk-for-the-mediterranean-aquatic-environment
#17
REVIEW
Fanny Desbiolles, Laure Malleret, Christophe Tiliacos, Pascal Wong-Wah-Chung, Isabelle Laffont-Schwob
Due to their pseudo-persistence and their biological activity, pharmaceuticals are emerging contaminants of major concern for the environment. The aim of this review is to provide an updated inventory of the contamination of aquatic environments by 43 drugs representing different classes of pharmaceuticals, such as antibiotics, anti-inflammatory drugs, anti-depressants, sex hormones, lipid regulators and beta-blockers. The data collected is focused on contamination levels reported in marine coastal waters and in waste and river waters flowing into the Mediterranean Sea...
October 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29929208/dna-barcoding-for-the-identification-of-phyllanthus-taxa-used-medicinally-in-brazil
#18
Peter W Inglis, Lorena R Mata, Marcos José da Silva, Roberto F Vieira, Rosa de B N Alves, Dijalma B Silva, Vânia C R Azevedo
Plants of the genus Phyllanthus, principally Phyllanthus amarus, Phyllanthus urinaria, Phyllanthus niruri , and Phyllanthus tenellus, are used in Brazilian folk medicine to treat kidney stones as well as other ailments, where the latter two species are listed in the Brazilian Pharmacopeia as quebra-pedra ( stone-breaker ). However, only P. niruri has been shown to be effective in a clinical setting. Nuclear ribosomal internal transcribed spacer (ITS1 - 5.8S rRNA-ITS2), internal transcribed spacer 2, and chloroplasts rbc L, mat K, psb A- trn H, trn L, and trn L- trn F were screened for their potential as DNA barcodes for the identification of 48 Phyllanthus taxa in Brazilian medicinal plant germplasm banks and in "living pharmacies"...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29928326/miltirone-induced-apoptosis-in-cisplatin-resistant-lung-cancer-cells-through-upregulation-of-p53-signaling-pathways
#19
Zhongcheng Zhu
The active ingredients of natural plants are important sources of antitumor agents. Miltirone is a major effective ingredient in traditional Chinese medicine and it is considered to have anti-infection and immunosuppressive activities. Clinically, it is often used for the treatment of arthritis and immune diseases. The effect of miltirone on cisplatin-resistant lung cancer cells has not been investigated to date. The present study aimed to examine the anticancer effect of miltirone in cisplatin-resistant lung cancer cells...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928122/the-effect-of-evening-primrose-oil-on-fatigue-and-quality-of-life-in-patients-with-multiple-sclerosis
#20
Nastaran Majdinasab, Foroogh Namjoyan, Mohsen Taghizadeh, Hamid Saki
Background: Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system that is characterized by demyelination in the central nervous system. In regard to the prevalence of diseases and enormous costs imposed on society and the health system, finding a way to stop the progression of the disease using drugs with fewer side effects seems a serious sanitation issue to the health of the international community. This study aimed to evaluate the effect of evening primrose oil (EPO) on fatigue and quality of life in patients with MS...
2018: Neuropsychiatric Disease and Treatment
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