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https://www.readbyqxmd.com/read/29035328/pterodontic-acid-isolated-from-laggera-pterodonta-inhibits-viral-replication-and-inflammation-induced-by-influenza-a-virus
#1
Wenda Guan, Jing Li, Qiaolian Chen, Zhihong Jiang, Rongping Zhang, Xinhua Wang, Zifeng Yang, Xiping Pan
Laggera pterodonta (DC.) Benth. is a traditional Chinese medicine. The previous study revealed that the crude extracts of this herb could inhibit influenza virus infection, but its anti-influenza components and underlying mechanism of action remain unknown. Column chromatography was performed to isolate components from the plant. Activity against influenza virus of the compound was determined by CPE inhibition assay. Neuraminidase (NA) inhibition was measured by chemiluminescence assay. The anti-virus and anti-inflammation effects were determined using dual-luciferase reporter assay, immunofluorescence, quantitative real-time PCR and luminex assay...
October 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29034955/a-review-of-issues-of-nomenclature-and-taxonomy-of-hypericum-perforatum-l-and-kew-s-medicinal-plant-names-services
#2
REVIEW
Elizabeth Anne Dauncey, Jason Thomas Whitley Irving, Robert Allkin
OBJECTIVES: To review which names are used to refer to Hypericum perforatum L. in health regulation and medicinal plant references, and the potential for ambiguity or imprecision. KEY FINDINGS: Structured searches of Kew's Medicinal Plant Names Services Resource, supplemented with other online bibliographic resources, found that the scientific name Hypericum perforatum L. is used consistently in the literature, but variation between subspecies is rarely considered by researchers...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034952/viscum-articulatum-burm-f-a-review-on-its-phytochemistry-pharmacology-and-traditional-uses
#3
REVIEW
Bhishma P Patel, Pawan K Singh
OBJECTIVES: The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. METHODS: Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034745/withanolide-production-by-fungal-endophyte-isolated-from-withania-somnifera
#4
Muthukrishnan Sathiyabama, Ramalingam Parthasarathy
Withanolides, the secondary metabolite from Withania species is used in Ayurvedic medicine and now proved to have potential use in treating cardiovascular, Alzheimer's disease, etc. Its production in plants varies between genotypes with very low yield. For improved industrial commercialisation, there is a need to increase its production. Endophytic fungi are symbiotically associated with plants and can synthesise the same bioactive compounds and natural products as their host plant. There are no reports available on withanolide-producing (endophytic) fungi...
October 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29034472/protective-effects-of-curcumin-against-aflatoxicosis-a-comprehensive-review
#5
REVIEW
Mohammad Mohajeri, Behzad Behnam, Arrigo F G Cicero, Amirhossein Sahebkar
Aflatoxicosis is a deleterious medical condition that results from aflatoxins (AFs) or ochratoxins (OTs). Contamination with these toxins exerts detrimental effects on the liver, kidneys, reproductive organs, and also on immunological and cardiovascular systems. Aflatoxicosis is closely associated with overproduction of reactive oxygen species (ROS) as key contributors to oxidative and nitrosative stress responses, and subsequent damages to lipids, proteins, RNA, and DNA. The main target organ for AF toxicity is the liver, where DNA adducts, degranulation of endoplasmic reticulum, increased hepatic lipid peroxide, GSH depletion, mitochondrial dysfunction, and reduction of enzymatic and non-enzymatic antioxidants are manifestations of aflatoxicosis...
October 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29034202/wound-healing-potentials-of-thevetia-peruviana-antioxidants-and-inflammatory-markers-criteria
#6
Nazneen Rahman, Haseebur Rahman, Mir Haris, Riaz Mahmood
Thevetia peruviana is a medicinal plant used in the treatment of external wounds, infected area, ring worms, tumours etc. in traditional system of medicine. The aim of the study was to evaluate the wound healing potentials of T. peruviana leaves hexane (LH) and fruit rind (FW) water extracts and to prove the folkloric claims. The antimicrobial, antioxidant and anti-inflammatory potentials could be important strategies in defining potent wound healing drug. Based on these approaches the current study was designed using incision, excision and dead space wound models with the biochemical, antioxidant enzymes and inflammatory marker analysis...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29034191/pharmacological-properties-of-salvia-officinalis-and-its-components
#7
Ahmad Ghorbani, Mahdi Esmaeilizadeh
Salvia officinalis (Sage) is a plant in the family of Labiatae/Lamiaceae. It is native to Middle East and Mediterranean areas, but today has been naturalized throughout the world. In folk medicine, S. officinalis has been used for the treatment of different kinds of disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhea, and hyperglycemia. In recent years, this plant has been a subject of intensive studies to document its traditional use and to find new biological effects...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29034189/antidiabetic-activity-of-extracts-of-anacardium-occidentale-linn-leaves-on-n-streptozotocin-diabetic-rats
#8
Y S Jaiswal, P A Tatke, S Y Gabhe, A B Vaidya
Anacardium occidentale L. (Anacardiaceae) is used in South Cameroon as well as in other tropical countries by traditional practitioners as a folk remedy for treatment of diabetes mellitus. We demonstrated the antidiabetic potential of the plant extracts in n-streptozotocin diabetic rats. The aim of the current study was to investigate the antidiabetic effects of ethanol extract of leaves of A. occidentale on neonatal streptozotocin diabetic rats. Two day old neonates were injected with 100 mg/kg of streptozotocin...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29034185/ashtawarga-plants-suffering-a-triple-standardization-syndrome
#9
REVIEW
Jaswinder Kaur Virk, Vikas Gupta, Sanjiv Kumar, Ranjit Singh, Parveen Bansal
Ayurveda is one of the oldest known holistic health care systems recommending diverse medicinal uses of plants for prevention and cure of diseases and illness. World Health Organization (WHO) estimates that the holistic system is gaining more popularity due to its easy availability, low cost, congeniality, better accessibility and higher safety than allopathic medicine. Demand of herbal drugs is increasing day-by-day because of increasing popularity of herbal drugs; however market fails to meet this supply due to numerous factors, one of the important factors being the extinction of these plants from local flora...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29034184/understanding-nutrition-and-immunity-in-disease-management
#10
REVIEW
Edwin L Cooper, Melissa J Ma
As we search for answers to modern medicine's most prevalent and challenging problems, the relationship between nutrition, immunity, and biological function of various natural compounds are preimminent. Nutritional research involving genomics provides rational capabilities for preventing disease. Scientific advances in genomic sequencing reveal opportunities for exploring diet-health relationships and potential for individual, genotype based dietary recommendations. Utilizing molecular and genetic technology to analyze impact of nutrition on genomics and metabolism reveals that nutrients may influence certain innate and/or acquired immune functions...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29034183/alzheimer-disease-clues-from-traditional-and-complementary-medicine
#11
REVIEW
Edwin L Cooper, Melissa J Ma
Despite modern medicine's incredible innovation and resulting accumulation of valuable knowledge, many of the world's most problematic diseases such as Alzheimer Disease (AD) still lack effective cures and treatments. Western medicine has revealed many genetic, cellular, and molecular processes that characterize AD such as protein aggregation and inflammation. As the need for novel and effective treatments increases, researchers have turned towards traditional medicine as a resource. Modern, evidence based research examining traditional and complementary remedies for AD has generated promising results within the last decade...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033832/cyclotides-isolated-from-an-ipecac-root-extract-antagonize-the-corticotropin-releasing-factor-type-1-receptor
#12
Mohsen Fahradpour, Peter Keov, Carlotta Tognola, Estela Perez-Santamarina, Peter J McCormick, Alireza Ghassempour, Christian W Gruber
Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular. Previously the cyclotide kalata B7 was identified to modulate the human oxytocin and vasopressin G protein-coupled receptors (GPCRs), providing molecular validation of the plants' uterotonic properties and further establishing cyclotides as valuable source for GPCR ligand design. In this study we screened a cyclotide extract derived from the root powder of the South American medicinal plant ipecac (Carapichea ipecacuanha) for its GPCR modulating activity of the corticotropin-releasing factor type 1 receptor (CRF1R)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29033234/antibacterial-constituents-of-the-plant-family-amaryllidaceae
#13
REVIEW
Jerald J Nair, Anke Wilhelm, Susanna L Bonnet, Johannes van Staden
There is a pressing need in antibiotic drug discovery for new drugs to counterbalance the effects of multidrug resistance. Plants represent a viable platform for such endeavors owing to their traditional relevance in infectious disease therapies as well as their vast chemical resources. As many as fifty different species of the Amaryllidaceae are discernible with such functions in traditional medicine, thirty-nine of which have been subjected to pharmacological evaluations. Submicromolar antibacterial activities for several of these plants have been the driving force behind studies targeting their active constituents...
September 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29032757/an-evidence-based-review-of-medicinal-herbs-for-the-treatment-of-gastroesophageal-reflux-disease-gerd
#14
Ayda Hosseinkhani, Kamran Bagheri Lankarani, Abdolali Mohagheghzadeh, Chunlin Long, Mehdi Pasalar
BACKGROUND: Gastroesophageal reflux disease (GERD) is one of the most common diseases in society, affecting up to 40% of the population. It has major impact on the quality of life and a high burden on medical expenditure. In this work, herbs used by ancient Iranians to treat GERD have been introduced. METHODS: Different well-known Persian textbooks and recent electronic databases were searched to explore the treatment of GERD and the pharmacological mechanisms of the identified medicinal plants...
October 10, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29032167/evaluation-of-embryotoxic-and-teratogenic-effects-of-the-oil-extracted-from-caryocar-brasiliense-cambess-pulp-in-rats
#15
Giseli Karenina Traesel, Fernando Freitas de Lima, Ariany Carvalho Dos Santos, Roosevelt Isaias Carvalho Souza, Daniela Torres Cantadori, Carlos Roberto Kretschmer, Vinicius João Navarini, Silvia Aparecida Oesterreich
The objective of this study was to evaluate the maternal, embryotoxic and teratogenic effects of Caryocar brasiliense pulp oil (OPCB), oil widely used in Brazilian cuisine and traditional medicine. Pregnant Wistar female rats were used in this study for three treatment groups (250, 500 and 1000 mg/kg/day) and a control group. The OPCB was administered orally throughout the period of organogenesis of females (6th until the 15th day of gestation). The pregnant females were gross necropsied on d20, followed by maternal and fetus examination, to evaluate the teratogenicity, reproductive and developmental performance of OPCB...
October 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29031657/achyrocline-alata-potentiates-repair-of-skin-full-thickness-excision-in-mice
#16
Luciana Xavier Pereira, Hygor Kleber Cabral Silva, Tamara Ribeiro Longatti, Patrícia Pereira Silva, Cláudia Di Lorenzo Oliveira, Anna Bárbara de Freitas Carneiro Proietti, Ralph Gruppi Thomé, Maria do Carmo Vieira, Carlos Alexandre Carollo, Daniel Pecoraro Demarque, João Máximo de Siqueira, Hélio Batista Dos Santos, Gleydes Gambogi Parreira, Rosy Iara Maciel de Azambuja Ribeiro
Plants of the Asteraceae family have been traditionally used as medicinal plants. The species Achyrocline satureioides and Achyrocline alata present anti-inflammatory properties and great chemical similarity. However, no study has been performed to evaluate the influence of these plants on skin wound healing in vivo. Here, we have assessed the effect of these plants extracts on skin wound healing in mice. Mice were randomly arranged into three groups (n = 10), an injury was performed on the dorsal area of the animals, which received the following topical treatment: group 1, control (ointment base); group 2, A...
September 29, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29030263/the-role-of-endemic-plants-in-mauritian-folkloric-medicine-therapeutic-efficacy-or-placebo-effect
#17
REVIEW
Nawraj Rummun, Vidushi S Neergheen-Bhujun, Kersley B Pynee, Cláudia Baider, Theeshan Bahorun
ETHNOPHARMACOLOGICAL RELEVANCE: The Mauritian endemic flora has been recorded to be used as medicinal for nearly 300 years. Despite acceptance of these endemic plants among the local population, proper documentation of their therapeutic uses is scarce. This review aims at summarizing documented traditional uses of Mauritian endemic plants with existing scientific data of their alleged bioactivities, showing there is a need for more stringent evidence-based validations for clinical efficacy...
October 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29030039/effect-of-acidic-and-enzymatic-pretreatment-on-the-analysis-of-mountain-tea-sideritis-spp-volatiles-via-distillation-and-ultrasound-assisted-extraction
#18
Virginia D Dimaki, Gregoris Iatrou, Fotini N Lamari
A number of beneficial medicinal properties are attributed to the extract and essential oil of the aerial parts of Sideritis species (Lamiaceae). Hydrodistillation of the aerial parts of wild Sideritis clandestina ssp. peloponnesiaca (an endemic taxon in northern Peloponnesus, Greece) gave a low essential oil yield (<0.12%); about 65 components, mainly α-pinene, β-caryophyllene, β-pinene, globulol, caryophyllene oxide, were identified via GC-MS. Internal and external standards were used for quantification...
October 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29030035/quali-quantitative-characterization-of-the-volatile-constituents-in-cordia-verbenacea-d-c-essential-oil-exploiting-advanced-chromatographic-approaches-and-nuclear-magnetic-resonance-analysis
#19
Danilo Sciarrone, Daniele Giuffrida, Archimede Rotondo, Giuseppe Micalizzi, Mariosimone Zoccali, Sebastiano Pantò, Paola Donato, Rosana Goncalves Rodrigues-das-Dores, Luigi Mondello
Cordia verbenacea D.C. (Boraginaceae, Varronia curassavica Jacq. synonym) is a medicinal plant, native from Brazil, especially the leaves are used in folk medicine. The aim of this study was to extend the characterization of the volatile fraction of the essential oil obtained from this plant, by using GC-FID, GC-MS, and chiral GC. Moreover, to further clarify the composition of the volatile fraction, preparative multidimensional-GC (prep-MDGC) was used to collect unknown compounds, followed by NMR characterization...
October 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29029598/a-method-for-named-entity-normalization-in-biomedical-articles-application-to-diseases-and-plants
#20
Hyejin Cho, Wonjun Choi, Hyunju Lee
BACKGROUND: In biomedical articles, a named entity recognition (NER) technique that identifies entity names from texts is an important element for extracting biological knowledge from articles. After NER is applied to articles, the next step is to normalize the identified names into standard concepts (i.e., disease names are mapped to the National Library of Medicine's Medical Subject Headings disease terms). In biomedical articles, many entity normalization methods rely on domain-specific dictionaries for resolving synonyms and abbreviations...
October 13, 2017: BMC Bioinformatics
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