keyword
https://read.qxmd.com/read/38341853/schwann-cell-promotes-macrophage-recruitment-through-il-17b-il-17rb-pathway-in-injured-peripheral-nerves
#21
JOURNAL ARTICLE
Yanju Huang, Liwen Wu, Yueshan Zhao, Jia Guo, Ruoyi Li, Suchen Ma, Zhengxin Ying
Macrophage recruitment to the injured nerve initiates a cascade of events, including myelin debris clearance and nerve trophic factor secretion, which contribute to proper nerve tissue repair. However, the mechanism of macrophage recruitment is still unclear. Here, by comparing wild-type with Mlkl-/- and Sarm1-/- mice, two mouse strains with impaired myelin debris clearance after peripheral nerve injury, we identify interleukin-17B (IL-17B) as a key regulator of macrophage recruitment. Schwann-cell-secreted IL-17B acts in an autocrine manner and binds to IL-17 receptor B to promote macrophage recruitment, and global or Schwann-cell-specific IL-17B deletion reduces macrophage infiltration, myelin clearance, and axon regeneration...
February 10, 2024: Cell Reports
https://read.qxmd.com/read/38331257/systems-genetics-of-influenza-a-virus-infected-mice-identifies-trim21-as-a-critical-regulator-of-pulmonary-innate-immune-response
#22
JOURNAL ARTICLE
Zhuoyuan Alex Li, Akhilesh Kumar Bajpai, Ruixue Wang, Yaxin Liu, Richard J Webby, Esther Wilk, Weikuan Gu, Klaus Schughart, Kui Li, Lu Lu
Tripartite motif 21 (TRIM21) is a cytosolic Fc receptor that targets antibody-bound, internalized pathogens for destruction. Apart from this intrinsic defense role, TRIM21 is implicated in autoimmune diseases, inflammation, and autophagy. Whether TRIM21 participates in host interactions with influenza A virus (IAV), however, is unknown. By computational modeling of body weight and lung transcriptome data from the BXD parents (C57BL/6J (B6) and DBA/2J (D2)) and 41 BXD mouse strains challenged by IAV, we reveal that a Trim21-associated gene network modulates the early host responses to IAV infection...
February 6, 2024: Virus Research
https://read.qxmd.com/read/38324324/sex-specific-pathways-from-prenatal-maternal-inflammation-to-adolescent-depressive-symptoms
#23
JOURNAL ARTICLE
Emily Lipner, Naoise Mac Giollabhui, Elizabeth C Breen, Barbara A Cohn, Nickilou Y Krigbaum, Piera M Cirillo, Thomas M Olino, Lauren B Alloy, Lauren M Ellman
IMPORTANCE: Prenatal maternal inflammation has been associated with major depressive disorder in offspring in adulthood as well as with internalizing and externalizing symptoms in childhood; however, the association between prenatal inflammation and offspring depression in adolescence has yet to be examined. OBJECTIVE: To determine whether maternal levels of inflammatory biomarkers during pregnancy are associated with depressive symptomatology in adolescent-aged offspring and to examine how gestational timing, offspring sex, and childhood psychiatric symptoms impact these associations...
February 7, 2024: JAMA Psychiatry
https://read.qxmd.com/read/38319998/cbl-b-mitigates-the-responsiveness-of-naive-cd8-t-cells-that-experience-extensive-tonic-t-cell-receptor-signaling
#24
JOURNAL ARTICLE
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth M Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Naive T cells experience tonic T cell receptor (TCR) signaling in response to self-antigens presented by major histocompatibility complex (MHC) in secondary lymphoid organs. We investigated how relatively weak or strong tonic TCR signals influence naive CD8+ T cell responses to stimulation with foreign antigens. The heterogeneous expression of Nur77-GFP, a transgenic reporter of tonic TCR signaling, in naive CD8+ T cells suggests variable intensities or durations of tonic TCR signaling. Although the expression of genes associated with acutely stimulated T cells was increased in Nur77-GFPHI cells, these cells were hyporesponsive to agonist TCR stimulation compared with Nur77-GFPLO cells...
February 6, 2024: Science Signaling
https://read.qxmd.com/read/38303095/genes-and-pathways-revealed-by-whole-transcriptome-analysis-of-milk-derived-bovine-mammary-epithelial-cells-after-escherichia-coli-challenge
#25
JOURNAL ARTICLE
Terhi Iso-Touru, Frank Panitz, Daniel Fischer, Minna K Kyläniemi, Suvi Taponen, Jonna Tabell, Anneli Virta, Johanna Vilkki
Mastitis, inflammation of the mammary gland, is the costliest disease in dairy cattle and a major animal welfare concern. Mastitis is usually caused by bacteria, of which staphylococci, streptococci and Escherichia coli are most frequently isolated from bovine mastitis. Bacteria activate the mammary immune system in variable ways, thereby influencing the severity of the disease. Escherichia coli is a common cause of mastitis in cattle causing both subclinical and clinical mastitis. Understanding of the molecular mechanisms that activate and regulate the host response would be central to effective prevention of mastitis and breeding of cows more resistant to mastitis...
February 1, 2024: Veterinary Research
https://read.qxmd.com/read/38287463/insights-into-the-mechanism-of-l-malic-acid-on-drip-loss-of-chicken-meat-under-commercial-conditions
#26
JOURNAL ARTICLE
Haijun Sun, Xue Yan, Lu Wang, Ruimin Zhu, Meixia Chen, Jingdong Yin, Xin Zhang
BACKGROUND: A deterioration in the meat quality of broilers has attracted much more attention in recent years. L-malic acid (MA) is evidenced to decrease meat drip loss in broilers, but the underlying molecular mechanisms are still unclear. It's also not sure whether the outputs obtained under experimental conditions can be obtained in a commercial condition. Here, we investigated the effects and mechanisms of dietary MA supplementation on chicken meat drip loss at large-scale rearing...
January 29, 2024: Journal of Animal Science and Biotechnology
https://read.qxmd.com/read/38285889/substance-basis-and-pharmacological-mechanism-of-heat-clearing-herbs-in-the-treatment-of-ischaemic-encephalopathy-a-systematic-review-and-network-pharmacology
#27
JOURNAL ARTICLE
Andong Zhao, Qianqian Sun, Jiahao Zhang, Tian Hu, Xuewei Zhou, Chuan Wang, Jiping Liu, Bin Wang
BACKGROUND AND OBJECTIVE: Ischaemic encephalopathy is a common cerebrovascular disease caused by insufficient blood supply to the cerebral vessels. The ischaemic encephalopathy is closely associated with the development of many chronic diseases such as obesity, hypertension and diabetes. Neurotrophic therapy has become the main therapeutic strategy for ischaemic encephalopathy. However, neurotrophic drugs only slightly recover the neurological function of patients, and their long-term efficacy is uncertain...
December 2024: Annals of Medicine
https://read.qxmd.com/read/38279604/cosentyx-alleviates-psoriasis-induced-podocyte-injury-by-inhibiting-the-tlr-nf-%C3%AE%C2%BAb-signaling-pathway
#28
JOURNAL ARTICLE
Wang Aixue, Wei Feng, Zhang Huanhuan, M Xixing, L Yanling
BACKGROUND: Pathological studies have shown an association between psoriasis and renal podocyte injury, and the specific mechanism of podocyte injury in psoriasis remains unclear, with no effective treatments currently available. This study aimed to investigate the underlying mechanisms of podocyte and epidermal cell injury in psoriasis and evaluate the therapeutic effect of Cosentyx. MATERIALS AND METHODS: A psoriasis-like mouse model was established using BALB/C mice, and Cosentyx treatment was administered via intraperitoneal injection...
February 2024: Skin Research and Technology
https://read.qxmd.com/read/38261838/cancer-immunotherapy-with-enveloped-self-amplifying-mrna-carg-2020-that-modulates-il-12-il-17-and-pd-l1-pathways-to-prevent-tumor-recurrence
#29
JOURNAL ARTICLE
Ju Chen, Bhaskara Reddy Madina, Elham Ahmadi, Timur Olegovich Yarovinsky, Marie Marthe Krady, Eileen Victoria Meehan, Isabella China Wang, Xiaoyang Ye, Elise Pitmon, Xian-Yong Ma, Bijan Almassian, Valerian Nakaar, Kepeng Wang
Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for humans. Here, we describe the application of virus-like vesicles (VLV) for delivery of three immunomodulators alone and in combination, as a promising approach for cancer immunotherapy. VLV vectors were designed to deliver single chain interleukin (IL)-12, short-hairpin RNA (shRNA) targeting programmed death ligand 1 (PD-L1), and a dominant-negative form of IL-17 receptor A (dn-IL17RA) as a single payload or as a combination payload...
January 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38259136/expression-of-il-17ra-in-innate-cells-of-patients-with-common-variable-immunodeficiency-cvid-and-its-clinical-implications
#30
JOURNAL ARTICLE
P Botelho Alves, H Pires Pereira, J Costa Carvalho, I Nunes, A Todo-Bom, E Faria, F Regateiro, A Paiva
Background. Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by B-cell dysfunction and immunoglobulin production deficiency. Dysregulation of interleukin-17 (IL-17) and its receptor IL-17RA have been reported in various immune disorders. This study aimed to investigate the expression of IL-17RA in innate immune cells of CVID patients and its correlation with clinical manifestations. Methods. A cross-sectional study included 22 CVID patients and 14 age- and sex-matched healthy controls...
January 23, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38258117/co-delivery-of-a-novel-lipidated-tlr7-8-agonist-and-hemagglutinin-based-influenza-antigen-using-silica-nanoparticles-promotes-enhanced-immune-responses
#31
JOURNAL ARTICLE
Walid M Abdelwahab, Sarah Auclair, Timothy Borgogna, Karthik Siram, Alexander Riffey, Hélène G Bazin, Howard B Cottam, Tomoko Hayashi, Jay T Evans, David J Burkhart
Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here, we report amine-grafted silica nanoparticles (A-SNP) as a tunable vaccine co-delivery platform for TLR7/8 agonists along with the recombinant influenza antigen hemagglutinin H7 (H7) to APCs. A-SNP of two different sizes (50 and 200 nm) were prepared and coated with INI-4001 at different coating densities, followed by co-adsorption of H7. Both INI-4001 and H7 showed >90% adsorption to the tested A-SNP formulations...
January 13, 2024: Pharmaceutics
https://read.qxmd.com/read/38232664/lipid-mediators-obtained-from-docosahexaenoic-acid-by-soybean-lipoxygenase-attenuate-rankl-induced-osteoclast-differentiation-and-rheumatoid-arthritis
#32
JOURNAL ARTICLE
Yan Su, Yunjon Han, Hack Sun Choi, Gil-Yong Lee, Hee Won Cho, Heonsik Choi, Jong Hyun Choi, Yong-Suk Jang, Jeong-Woo Seo
Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by persistent inflammation and joint destruction. A lipid mediator (LM, namely, 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX in a ratio of 3:47:50) produced by soybean lipoxygenase from DHA, exhibits anti-inflammatory activity. In this study, we determined the effect of LM on collagen antibody-induced arthritis (CAIA) in mice and receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation in RAW264...
February 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38230768/identification-of-peanut-skin-components-for-treating-hepatocellular-carcinoma-via-network-pharmacology-and-in%C3%A2-vitro-experiments
#33
JOURNAL ARTICLE
Sha Li, Wen Liu, Tong-Tong Wang, Tong-Qiang Chen, Jin-Cai Guo
Peanut skin (PS) contains various flavonoids and phenols that have antitumor and antioxidant effects. However, no research has been conducted on PS and hepatocellular carcinoma (HCC). Therefore, this study sought to explore the potential mechanism of PS in treating HCC. PS was searched for in the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and SYMMAP databases. HCC targets were searched for in five major databases. Protein-protein interaction network, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses were performed...
January 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38227652/%C3%AE-%C3%AE-t-cell-antigen-receptor-polyspecificity-enables-t-cell-responses-to-a-broad-range-of-immune-challenges
#34
JOURNAL ARTICLE
Jing Guo, Roshni Roy Chowdhury, Vamsee Mallajosyula, Jianming Xie, Megha Dubey, Yuanyuan Liu, Jing Li, Yu-Ling Wei, Brad A Palanski, Conghua Wang, Lingfeng Qiu, Mané Ohanyan, Oliver Kask, Elsa Sola, Lilit Kamalyan, David B Lewis, Thomas J Scriba, Mark M Davis, Dylan Dodd, Xun Zeng, Yueh-Hsiu Chien
γδ T cells are essential for immune defense and modulating physiological processes. While they have the potential to recognize large numbers of antigens through somatic gene rearrangement, the antigens which trigger most γδ T cell response remain unidentified, and the role of antigen recognition in γδ T cell function is contentious. Here, we show that some γδ T cell receptors (TCRs) exhibit polyspecificity, recognizing multiple ligands of diverse molecular nature...
January 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38219844/effects-of-the-mineralocorticoid-receptor-antagonist-eplerenone-in-experimental-autoimmune-encephalomyelitis
#35
JOURNAL ARTICLE
Guido S Alvarez Quintero, Analia Lima, Paulina Roig, Maria Meyer, E Ron de Kloet, Alejandro F De Nicola, Laura I Garay
There is growing evidence indicating that mineralocorticoid receptor (MR) expression influences a wide variety of functions in metabolic and immune response. The present study explored if antagonism of the MR reduces neuroinflammation in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE). Eplerenone (EPLE) (100mg/kg dissolved in 30% 2-hydroxypropyl-β-cyclodextrin) was administered intraperitoneally (i.p.) daily from EAE induction (day 0) until sacrificed on day 17 post-induction...
January 12, 2024: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/38207130/propionate-functions-as-a-feeding-state-dependent-regulatory-metabolite-to-counter-pro-inflammatory-signaling-linked-to-nutrient-load-and-obesity
#36
JOURNAL ARTICLE
Kim Han, Allison M Meadows, Matthew J Rodman, Anna Chiara Russo, Rahul Sharma, Komudi Singh, Shahin Hassanzadeh, Pradeep K Dagur, Rebecca D Huffstutler, Fynn N Krause, Julian L Griffin, Yvonne Baumer, Tiffany M Powell-Wiley, Michael N Sack
Generally, fasting and refeeding confer anti- and pro-inflammatory effects, respectively. In humans, these caloric-load interventions function, in part, via regulation of CD4+ T cell biology. However, mechanisms orchestrating this regulation remain incomplete. We employed integrative bioinformatics of RNA-seq and HPLC-mass spectrometry data to measure serum metabolites and gene expression of peripheral blood mononuclear cells isolated from fasting and refeeding in volunteers to identify nutrient-load metabolite-driven immunoregulation...
January 11, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38204622/ischemic-myocardial-inflammatory-signaling-in-starvation-versus-hypoxia-derived-extracellular-vesicles-a-comparative-analysis
#37
JOURNAL ARTICLE
Mohamed Sabra, Sharif A Sabe, Dwight D Harris, Cynthia M Xu, Mark Broadwin, Krishnah G Bellam, Debolina Banerjee, M Ruhul Abid, Frank W Sellke
BACKGROUND: Coronary artery disease remains a leading cause of death worldwide. Bone mesenchymal stem cell-derived extracellular vesicles (EVs) have shown promise in the setting of myocardial ischemia. Furthermore, the properties of the EVs can be modified via preconditioning of progenitor cells. Previous research from our lab demonstrated a significant decrease in proinflammatory signaling following treatment with EVs derived from starvation preconditioning of human bone mesenchymal stem cells (MVM EVs) in a porcine model of chronic myocardial ischemia...
December 2023: JTCVS open
https://read.qxmd.com/read/38196838/prediction-of-an-immunogenic-peptide-ensemble-and-multi-subunit-vaccine-for-visceral-leishmaniasis-using-bioinformatics-approaches
#38
JOURNAL ARTICLE
Manu Kupani, Rajeev Kumar Pandey, Sharad Vashisht, Satyendra Singh, Vijay Kumar Prajapati, Sanjana Mehrotra
Visceral Leishmaniasis (VL) is a neglected tropical disease of public health importance in the Indian subcontinent. Despite consistent elimination initiatives, the disease has not yet been eliminated and there is an increased risk of resurgence from active VL reservoirs including asymptomatic, post kala azar dermatitis leishmaniasis (PKDL) and HIV-VL co-infected individuals. To achieve complete elimination and sustain it in the long term, a prophylactic vaccine, which can elicit long lasting immunity, is desirable...
December 2023: Heliyon
https://read.qxmd.com/read/38188548/molecular-mechanism-of-xuebijing-in-treating-pyogenic-liver-abscess-complicated-with-sepsis
#39
JOURNAL ARTICLE
Wei Zhou, Maiying Fan, Xiang Li, Fang Yu, En Zhou, Xiaotong Han
BACKGROUND: Xuebijing (XBJ) can alleviate the inflammatory response, improve organ function, and shorten the intensive care unit (ICU) stay in patients with pyogenic liver abscess (PLA) complicated with sepsis, but the molecular mechanisms have not been elucidated. This study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology approach. METHODS: The active ingredients and targets of XBJ were retrieved from the ETCM database...
2024: World Journal of Emergency Medicine
https://read.qxmd.com/read/38168873/differences-in-toll-like-receptor-ligand-induced-cytokine-concentrations-before-and-after-solid-organ-transplantation-a-prospective-observational-cohort-study-in-a-clinical-setting
#40
JOURNAL ARTICLE
Dina Leth Møller, Søren Schwartz Sørensen, Michael Perch, Finn Gustafsson, Annemette Hald, Andreas Delhbæk Knudsen, Ranya Abdulovski, Nicoline Stender Arentoft, Jens Lundgren, Allan Rasmussen, Sisse Rye Ostrowski, Susanne Dam Nielsen
Reliable methods to assess immune function after solid organ transplantation (SOT) are needed to guide dosing of immunosuppression. We hypothesized that toll-like receptor ligand-induced cytokine concentrations would decrease post-transplantation due to the use of immunosuppressive medication. Furthermore, we hypothesized that induced cytokine concentrations pre-transplantation would be higher in recipients with episodes of acute rejection post-transplantation due to underlying immunological dispositions. We aimed to investigate toll-like receptor ligand-induced cytokine concentrations by TruCulture©, a standardized immunoassay, in SOT recipients before and 3 months after SOT and explored associations with methylprednisolone-treated acute rejections...
November 20, 2023: Scandinavian Journal of Immunology
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