Jing Guo, Roshni Roy Chowdhury, Vamsee Mallajosyula, Jianming Xie, Megha Dubey, Yuanyuan Liu, Jing Li, Yu-Ling Wei, Brad A Palanski, Conghua Wang, Lingfeng Qiu, Mané Ohanyan, Oliver Kask, Elsa Sola, Lilit Kamalyan, David B Lewis, Thomas J Scriba, Mark M Davis, Dylan Dodd, Xun Zeng, Yueh-Hsiu Chien
γδ T cells are essential for immune defense and modulating physiological processes. While they have the potential to recognize large numbers of antigens through somatic gene rearrangement, the antigens which trigger most γδ T cell response remain unidentified, and the role of antigen recognition in γδ T cell function is contentious. Here, we show that some γδ T cell receptors (TCRs) exhibit polyspecificity, recognizing multiple ligands of diverse molecular nature...
January 23, 2024: Proceedings of the National Academy of Sciences of the United States of America