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IL 17 receptor B

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https://www.readbyqxmd.com/read/29191572/th17%C3%A2-cells-in-primary-sj%C3%A3-gren-s-syndrome-pathogenicity-and-plasticity
#1
REVIEW
Gwenny M Verstappen, Odilia B J Corneth, Hendrika Bootsma, Frans G M Kroese
Th17 cells play an important physiological role at mucosal barriers, and are involved in inflammatory responses to pathogens. Th17 cells and their signature cytokine IL-17 are also present in salivary gland lesions of primary Sjögren's syndrome (pSS) patients and can be elevated in their peripheral blood. In pSS patients, clear correlations between increased Th17 cell activity and symptoms of the disease have not been found, but Th17 cells may contribute to disease progression, for example by supporting autoreactive B cell responses...
November 27, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29189980/patients-with-type-1-diabetes-mellitus-have-impaired-il-1%C3%AE-production-in-response-to-mycobacterium-tuberculosis
#2
E Lachmandas, K Thiem, C van den Heuvel, A Hijmans, B E de Galan, C J Tack, M G Netea, R van Crevel, J A van Diepen
Patients with diabetes mellitus have an increased risk of developing tuberculosis. Although the underlying mechanism is unclear, evidence suggests a role for chronic hyperglycaemia. We examined the influence of hyperglycaemia on Mycobacterium tuberculosis-induced cytokine responses in patients with type 1 diabetes mellitus (T1D). Peripheral blood mononuclear cells (PBMCs) from 24 male T1D patients with sub-optimal glucose control [HbA1c > 7.0% (53 mmol/L)] and from 24 age-matched male healthy controls were stimulated with M...
November 30, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29168181/different-il-17-secreting-tlr-t-cell-subsets-are-associated-with-disease-activity-in-multiple-sclerosis
#3
Thais B Ferreira, Joana Hygino, Ana Cristina Wing, Taissa M Kasahara, Priscila M Sacramento, Solange Camargo, Fernanda Rueda, Soniza V Alves-Leon, Regina Alvarenga, Claudia Cristina Vasconcelos, Anshu Agrawal, Sudhir Gupta, Cleonice A M Bento
Signaling through toll-like receptors (TLRs) may play a role in the pathogenesis of autoimmune diseases, such as multiple sclerosis (MS). In the present study, the expression of TLR2, TLR4 and TLR9 was significantly higher on CD4(+) and CD8(+) T cells from MS patients as compared to healthy individuals. Following in vitro activation, the proportion of IL-17+ and IL-6+ CD4+ and CD8+ T cells was higher in the patients. In addition, the proportion of IFN-γ-secreting TLRs(+) CD8(+) T cells was increased in MS patients...
November 23, 2017: Immunology
https://www.readbyqxmd.com/read/29142230/unique-transcriptome-signatures-and-gm-csf-expression-in-lymphocytes-from-patients-with-spondyloarthritis
#4
M H Al-Mossawi, L Chen, H Fang, A Ridley, J de Wit, N Yager, A Hammitzsch, I Pulyakhina, B P Fairfax, D Simone, Yao Yi, S Bandyopadhyay, K Doig, R Gundle, B Kendrick, F Powrie, J C Knight, P Bowness
Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSF-producing CD4 and CD8 lymphocytes in the blood and joints of patients with spondyloarthritis, and increased numbers of IL-17A(+)GM-CSF(+) double-producing CD4, CD8, γδ and NK cells. GM-CSF production in CD4 T cells occurs both independently and in combination with classical Th1 and Th17 cytokines. Type 3 innate lymphoid cells producing predominantly GM-CSF are expanded in synovial tissues from patients with spondyloarthritis...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29140228/co-factor-independent-phosphoglycerate-mutase-of-leishmania-donovani-modulates-macrophage-signalling-and-promotes-t-cell-repertoires-bearing-epitopes-for-both-mhc-i-and-mhc-ii
#5
Manish K Singh, Fauzia Jamal, Amit K Dubey, Pushkar Shivam, Sarita Kumari, Pushpanjali, Ghufran Ahmed, Manas R Dikhit, S Narayan, V N R DAS, Krishna Pandey, K K Sinha, P DAS, Shubhankar K Singh
Immunoactivation depends upon the antigen potential to modulate T-cell repertoires. The present study has enumerated the effect of 61 kDa recombinant Leishmania donovani co-factor-independent phosphoglycerate mutase (rLd-iPGAM) on mononuclear cells of healthy and treated visceral leishmaniasis subjects as well as on THP-1 cell line. rLd-iPGAM stimulation induced higher expression of interleukin-1β (IL-1β) in the phagocytic cell, its receptor and CD69 on T-cell subsets. These cellular activations resulted in upregulation of host-protective cytokines IL-2, IL-12, IL-17, tumour necrosis factor-α and interferon-γ, and downregulation of IL-4, IL-10 and tumour growth factor-β...
November 15, 2017: Parasitology
https://www.readbyqxmd.com/read/29091911/il-23-signaling-in-th17-cells-is-inhibited-by-hiv-infection-and-is-not-restored-by-haart-implications-for-persistent-immune-activation
#6
Jason R Fernandes, Tamara K Berthoud, Ashok Kumar, Jonathan B Angel
OBJECTIVES: HIV infection causes a profound depletion of gut derived Th17 cells, contributing to loss of mucosal barrier function and an increase in microbial translocation, thus driving systemic immune activation. Despite normalization of circulating CD4+ T cell counts with highly active antiretroviral therapy (HAART), Th17 frequency and function often remain impaired. Given the importance of interleukin (IL)-23 in the generation and stabilization of Th17 cells we hypothesized that impaired IL-23 signaling causes persistent Th17 dysfunction in HIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/29091865/the-role-of-sirt1-in-diabetic-retinopathy
#7
REVIEW
Hedyieh Karbasforooshan, Gholamreza Karimi
The prevalence of diabetes mellitus (DM), has been increasing worldwide. Diabetic retinopathy (DR) is the most common microvascular complication in diabetes. It is a multifactorial disease that occurs primarily through the long-term detrimental effects of hyperglycemia. The pathogenesis of DR is complex, including inflammation, oxidative stress and advanced glycation end products (AGES). SIRT1 is a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase that removes acetyl groups from proteins which can be implicated in DR...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29069649/the-systemic-activation-of-programmed-death-1-pd-l1-axis-protects-systemic-lupus-erythematosus-model-from-nephritis
#8
Wenjun Liao, Hua Zheng, Sha Wu, Yanmei Zhang, Wei Wang, Zili Zhang, Chenfei Zhou, Hongjun Wu, Jie Min
BACKGROUND: Systemic lupus erythematosus (SLE) is characterized by abnormal activated T cells, autoreactive B cells, and massive cytokines. The CD4+ T cells determined B-cells differentiation and cytokines production. The programmed death 1 (PD-1) is the checkpoint immunoinhibitory receptor of activated T cells, and its engagement could exhaust T cells. In this study, we investigated the role of PD-1 systemic engagement with PD-L1-Ig in lupus-like nephritis in SLE mice. METHODS: The murine PD-L1-Ig was injected into SLE-prone mice...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#9
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28985996/tlr-induced-secretion-of-novel-cytokine-il-27-is-defective-in-newly-diagnosed-type-2-diabetic-subjects
#10
Haridoss Madhumitha, Viswanathan Mohan, Subash Babu, Vivekanandhan Aravindhan
Toll-like receptors (TLRs), the innate immune receptors, act as sentinels bridging both innate and adaptive arms of immunity. In the present study, we estimated TLR-induced secretion of IL-27, IL-12, IL-23, IL-8, IP-10, IL-17, IL-6 and TNF-α (by ELISA) and expression of Human Leukocyte Antigen- (Human Leukocyte Antigen - antigen D Related (HLA-DR), CD69, CD80 (also known asB7-1) (by flowcytometry) and Activating Transcription Factor 3(ATF3) (by qRT-PCR) in whole blood cultures of control and type-2 diabetic (both newly diagnosed/NDD and known/KDM) subjects...
October 3, 2017: Cytokine
https://www.readbyqxmd.com/read/28970254/silybin-inhibits-nlrp3-inflammasome-assembly-through-the-nad-sirt2-pathway-in-mice-with-nonalcoholic-fatty-liver-disease
#11
Bangling Zhang, Dan Xu, Linlin She, Zixia Wang, Na Yang, Runbin Sun, Yirui Zhang, Caixia Yan, Qingli Wei, Jiye Aa, Baolin Liu, Guangji Wang, Yuan Xie
Silybin is one of the effective, traditional Chinese medicines used as a hepatoprotective agent in nonalcoholic fatty liver disease (NAFLD) therapy worldwide, and the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been recognized as an important factor involved in NAFLD development. However, little is known about the mechanisms of silybin in the regulation of high-fat diet (HFD)-induced liver inflammation. In our study, we found that silybin inhibited endoplasmic reticulum stress and NLRP3 inflammasome activation in the livers of HFD-fed mice and in cultured hepatocytes...
September 27, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28935156/activation-of-il-17-receptor-leads-to-increased-oxidative-inflammation-in-peripheral-monocytes-of-autistic-children
#12
Ahmed Nadeem, Sheikh F Ahmad, Sabry M Attia, Saleh A Bakheet, Naif O Al-Harbi, Laila Y Al-Ayadhi
Millions of children are affected by different neurodevelopmental disorders, out of which autism spectrum disorder (ASD) poses a major hurdle to normal life style due to associated behavioral abnormalities. Several studies have shown an increased expression/release of Th17 related cytokine, IL-17A in ASD. IL-17A may enhance neuroinflammation via its IL-17A receptor, i.e. IL-17RA expressed in immune cells (such as monocytes) of autistic children. Increased oxidative stress has been implicated in a number of neuropsychiatric disorders including ASD...
January 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28932959/the-role-and-regulation-of-the-11-beta-hydroxysteroid-dehydrogenase-enzyme-system-in-patients-with-inflammatory-bowel-disease
#13
M Hussey, G Holleran, S Smith, Mark Sherlock, D McNamara
INTRODUCTION: Glucocorticoids are known to modulate a number of immunological responses including counteracting inflammation. Within tissues expressing the glucocorticoid and mineralocorticoid receptors including the colon, glucocorticoid metabolism is regulated by the isoenzymes of 11ß-hydroxysteroid dehydrogenase (11β-HSD). 11β-HSD1 acts as an oxidoreductase converting inactive cortisone into active cortisol, while 11β-HSD2 acts as a dehydrogenase converting active cortisol to inactive cortisone...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28922563/role-of-il-18-in-atopic-asthma-is-determined-by-balance-of-il-18-il-18bp-il-18r
#14
Huiyun Zhang, Junling Wang, Ling Wang, Hua Xie, Liping Chen, Shaoheng He
It is recognized that IL-18 is related to development of asthma, but role of IL-18 in asthma remains controversial and confusing. This is largely due to lack of information on expression of IL-18 binding protein (BP) and IL-18 receptor (R) in asthma. In this study, we found that plasma levels of IL-18 and IL-18BP were elevated in asthma. The ratio between plasma concentrations of IL-18 and IL-18BP was 1:12.8 in asthma patients. We demonstrated that 13-fold more monocytes, 17.5-fold more neutrophils and 4.1-fold more B cells express IL-18BP than IL-18 in asthmatic blood, suggesting that there is excessive amount of IL-18BP to abolish actions of IL-18 in asthma...
September 18, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28916002/characterization-of-immune-response-in-staphylococcus-aureus-chronically-infected-bovine-mammary-glands-during-active-involution
#15
Carolina S Andreotti, Celina Baravalle, Sofía C Sacco, Melisa Lovato, Elizabet A L Pereyra, María S Renna, Hugo H Ortega, Luis F Calvinho, Bibiana E Dallard
The aim of this study was to characterize the immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturally acquired S. aureus intramammary infections (IMI) were included in this study. Cows were slaughtered at 7, 14 and 21 d after cessation of milking and samples for immunohistochemical analysis were taken. Protein expression of toll-like receptor 2 (TLR2) and TLR4 was significantly higher in S...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28898280/ilc2s-activated-by-il-25-promote-antigen-specific-th2-and-th9-functions-that-contribute-to-the-control-of-trichinella-spiralis-infection
#16
Pornpimon Angkasekwinai, Wichuda Sodthawon, Siranart Jeerawattanawart, Adithap Hansakon, Kovit Pattanapanyasat, Yui-Hsi Wang
IL-25, an IL-17 family cytokine, derived from epithelial cells was shown to regulate Th2- and Th9-type immune responses. We previously reported that IL-25 was important in promoting efficient protective immunity against T. spiralis infection; however, the cellular targets of IL-25 to elicit type-2 immunity during infection have not yet been addressed. Here, we investigated IL-25-responding cells and their involvement in mediating type-2 immune response during T. spiralis infection. ILC2 and CD4+ Th2 cells residing in the gastrointestinal tract of T...
2017: PloS One
https://www.readbyqxmd.com/read/28878128/respiratory-syncytial-virus-infection-of-newborn-cx3cr1-deficent-mice-induces-a-pathogenic-pulmonary-innate-immune-response
#17
Sudipta Das, Mahesh Raundhal, Jie Chen, Timothy B Oriss, Rachael Huff, John V Williams, Anuradha Ray, Prabir Ray
Respiratory syncytial virus (RSV) infects almost all infants by 2 years of age, and severe bronchiolitis resulting from RSV infection is the primary cause of hospitalization in the first year of life. Among infants hospitalized due to RSV-induced bronchiolitis, those with a specific mutation in the chemokine receptor CX3CR1, which severely compromises binding of its ligand CX3CL1, were at a higher risk for more severe viral bronchiolitis than those without the mutation. Here, we show that RSV infection of newborn mice deficient in CX3CR1 leads to significantly greater neutrophilic inflammation in the lungs, accompanied by an increase in mucus production compared with that induced in WT mice...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28866647/chemotaxis-of-v%C3%AE-2-t-cells-to-the-joints-contributes-to-the-pathogenesis-of-rheumatoid-arthritis
#18
Wen-Xiu Mo, Shan-Shan Yin, Hua Chen, Chen Zhou, Jia-Xin Zhou, Li-Dan Zhao, Yun-Yun Fei, Hua-Xia Yang, Jing-Bo Guo, Yu-Jia Mao, Lin-Fang Huang, Wen-Jie Zheng, Wen Zhang, Jian-Min Zhang, Wei He, Xuan Zhang
OBJECTIVES: To explore the role of Vδ2 T cells in the pathogenesis of rheumatoid arthritis (RA). METHODS: Sixty-eight patients with RA, 21 patients with osteoarthritis and 21 healthy controls were enrolled in the study. All patients with RA fulfilled the 2010 American College of Rheumatology/European League Against Rheumatism criteria for RA. Peripheral Vδ2T population, chemokine receptor expression and proinflammatory cytokine secretion were quantified by flow cytometry...
September 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28853490/interleukin-26-production-in-human-primary-bronchial-epithelial-cells-in-response-to-viral-stimulation-modulation-by-th17-cytokines
#19
Karlhans Fru Che, Riitta Kaarteenaho, Elisa Lappi-Blanco, Bettina Levänen, Jitong Sun, Åsa Wheelock, Lena Palmberg, C Magnus Sköld, Anders Lindén
Interleukin (IL)-26 is abundant in human airways and this cytokine is involved in the local immune response to a bacterial stimulus in vivo. Specifically, local exposure to the toll-like receptor (TLR) 4 agonist endotoxin does increase IL-26 in human airways and this cytokine potentiates chemotactic responses in human neutrophils. In addition to T-helper (Th) 17 cells, alveolar macrophages can produce IL-26, but it remains unknown whether this cytokine can also be produced in the airway mucosa per se in response to a viral stimulus...
August 29, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28837629/effects-of-subconjunctival-administration-of-anti-high-mobility-group-box-1-on-dry-eye-in-a-mouse-model-of-sj%C3%B3-gren-s-syndrome
#20
Kyeong Hwan Kim, Dong Hyun Kim, Hyun Jeong Jeong, Jin Suk Ryu, Yu Jeong Kim, Joo Youn Oh, Mee Kum Kim, Won Ryang Wee
PURPOSE: Extracellular high mobility group box 1 (HMGB1) acts as a damage associated molecular pattern molecule through the Toll-like receptor to promote autoreactive B cell activation, which may be involved in the pathogenesis of Sjӧgren's syndrome. The aim of this study was to investigate the effect of subconjunctival administration of anti-HMGB1 on dry eye in a mouse model of Sjӧgren's syndrome. METHODS: Ten weeks-old NOD.B10.H2b mice were subconjunctivally injected with 0...
2017: PloS One
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