keyword
https://read.qxmd.com/read/38382546/scfas-supplementation-rescues-anxiety-and-depression-like-phenotypes-generated-by-fecal-engraftment-of-treatment-resistant-depression-rats
#21
JOURNAL ARTICLE
Mani Surya Kumar Palepu, Siva Nageswara Rao Gajula, Malleshwari K, Rajesh Sonti, Manoj P Dandekar
Alteration of gut microbiota and microbial metabolites such as short-chain fatty acids (SCFAs) coexisted with stress-generated brain disorders, including depression. Herein, we investigated the effect of SCFAs in a treatment-resistant depression (TRD) model of rat. Rats were exposed to chronic-unpredictable mild stress (CUMS) and repeated adrenocorticotropic hormone (ACTH) injections to generate a TRD-like phenotype. The cecal contents of these animals were engrafted into healthy-recipient rats and allowed to colonize for 4 weeks (TRD-FMT group)...
February 21, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38372823/cord-blood-transplantation-for-very-early-onset-inflammatory-bowel-disease-caused-by-interleukin-10-receptor-deficiency
#22
JOURNAL ARTICLE
Ping Wang, Xiaowen Qian, Wenjin Jiang, Hongsheng Wang, Yuhuan Wang, Ying Zhou, Ye Zhang, Ying Huang, Xiaowen Zhai
PURPOSE: Interleukin-10 receptor (IL-10R) deficiency can result in life-threatening very early-onset inflammatory bowel disease (VEO-IBD). Umbilical cord blood transplantation (UCBT) is a curative therapy for patients with IL-10R deficiency. This study aimed to investigate the efficacy of UCBT in treating IL-10R deficiency and develop a predictive model based on pre-transplant factors. METHODS: Eighty patients with IL-10R deficiency who underwent UCBT between July 2015 and April 2023 were retrospectively analyzed...
February 19, 2024: Journal of Clinical Immunology
https://read.qxmd.com/read/38339203/trpv1-channel-in-human-eosinophils-functional-expression-and-inflammatory-modulation
#23
JOURNAL ARTICLE
Tobias Weihrauch, Natalie Gray, Daniela Wiebe, Martin Schmelz, Maren M Limberg, Ulrike Raap
The transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel expressed on sensory neurons and immune cells. We hypothesize that TRPV1 plays a role in human eosinophil function and is modulated by inflammatory conditions. TRPV1 expression on human eosinophils was examined by qPCR, flow cytometry, and immunohistochemistry, respectively. TRPV1 functionality was analyzed by investigating calcium flux, apoptosis, modulation by cytokines and acidic pH, and CD69 externalization using flow cytometry...
February 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38339133/impact-of-glucagon-like-peptide-1-receptor-agonists-on-biochemical-markers-of-the-initiation-of-atherosclerotic-process
#24
JOURNAL ARTICLE
Marcin Hachuła, Michał Kosowski, Sabina Ryl, Marcin Basiak, Bogusław Okopień
Atherosclerosis stands out as one of the leading causes of global mortality. The inflammatory response against vascular wall components plays a pivotal role in the atherogenic process. The initiation of this process is notably driven by oxidized low-density lipoprotein (oxLDL) and a range of pro-inflammatory cytokines, with interleukin-1β (Il-1β) and tumor necrosis factor α (TNFα) emerging as particularly significant in the early stages of atherosclerotic plaque formation. In recent years, researchers worldwide have been diligently exploring innovative therapeutic approaches for metabolic diseases, recognizing their impact on the atherogenesis process...
February 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38339048/chemogenetics-modulation-of-electroacupuncture-analgesia-in-mice-spared-nerve-injury-induced-neuropathic-pain-through-trpv1-signaling-pathway
#25
JOURNAL ARTICLE
I-Han Hsiao, Chia-Ming Yen, Hsin-Cheng Hsu, Hsien-Yin Liao, Yi-Wen Lin
Neuropathic pain, which is initiated by a malfunction of the somatosensory cortex system, elicits inflammation and simultaneously activates glial cells that initiate neuroinflammation. Electroacupuncture (EA) has been shown to have therapeutic effects for neuropathic pain, although with uncertain mechanisms. We suggest that EA can reliably cure neuropathic disease through anti-inflammation and transient receptor potential V1 (TRPV1) signaling pathways from the peripheral to the central nervous system. To explore this, we used EA to treat the mice spared nerve injury (SNI) model and explore the underlying molecular mechanisms through novel chemogenetics techniques...
February 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38339021/structural-analysis-of-breast-milk-%C3%AE-s1-casein-an-%C3%AE-helical-conformation-is-required-for-tlr4-stimulation
#26
JOURNAL ARTICLE
Thorsten Saenger, Marten F Schulte, Stefan Vordenbäumen, Fabian C Hermann, Juliana Bertelsbeck, Kathrin Meier, Ellen Bleck, Matthias Schneider, Joachim Jose
Breast-milk αS1 -casein is a Toll-like receptor 4 (TLR4) agonist, whereas phosphorylated αS1 -casein does not bind TLR4. The objective of this study was to analyse the structural requirements for these effects. In silico analysis of αS1 -casein indicated high α-helical content with coiled-coil characteristics. This was confirmed by CD-spectroscopy, showing the α-helical conformation to be stable between pH 2 and 7.4. After in vitro phosphorylation, the α-helical content was significantly reduced, similar to what it was after incubation at 80 °C...
February 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38339008/p2x7-receptor-induced-human-mast-cell-degranulation-is-enhanced-by-interleukin-33
#27
JOURNAL ARTICLE
Barbora Salcman, Rajia Bahri, Peter W West, Chiara Tontini, Karen Affleck, Silvia Bulfone-Paus
MCs are tissue-resident immune cells that strategically reside in barrier organs and respond effectively to a wide range of stimuli, such as IL-33, a mediator released upon epithelial damage. Adenosine triphosphate (ATP) accumulates at sites of tissue injury and is known to modulate MC activities. This study investigated how an inflammatory tissue environment rich in IL-33 modulates the ATP-mediated activation of MCs. Human primary MCs primed with IL-33 displayed a strongly increased response to ATP but not ADP...
January 31, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338983/the-new-therapeutic-frontiers-in-the-treatment-of-eosinophilic-esophagitis-biological-drugs
#28
REVIEW
Erminia Ridolo, Alessandro Barone, Martina Ottoni, Silvia Peveri, Marcello Montagni, Francesca Nicoletta
Eosinophilic esophagitis (EoE) is a multifaceted disease characterized by a wide heterogeneity of clinical manifestations, endoscopic and histopathologic patterns, and responsiveness to therapy. From the perspective of an effective approach to the patient, the different inflammatory mechanisms involved in the pathogenesis of EoE and biologics, in particular monoclonal antibodies (mAbs), targeting these pathways are needed. Currently, the most relevant is dupilumab, which interferes with both interleukin (IL)-4 and IL-13 pathways by binding IL-4 receptor α, and is the only mAb approved by the European Medicine Agency and US Food and Drug Administration for the treatment of EoE...
January 30, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338960/cb2-cannabinoid-receptor-as-a-potential-target-in-myocardial-infarction-exploration-of-molecular-pathogenesis-and-therapeutic-strategies
#29
REVIEW
Sagar A More, Rucha S Deore, Harshal D Pawar, Charu Sharma, Kartik T Nakhate, Sumit S Rathod, Shreesh Ojha, Sameer N Goyal
The lipid endocannabinoid system has recently emerged as a novel therapeutic target for several inflammatory and tissue-damaging diseases, including those affecting the cardiovascular system. The primary targets of cannabinoids are cannabinoid type 1 (CB1) and 2 (CB2) receptors. The CB2 receptor is expressed in the cardiomyocytes. While the pathological changes in the myocardium upregulate the CB2 receptor, genetic deletion of the receptor aggravates the changes. The CB2 receptor plays a crucial role in attenuating the advancement of myocardial infarction (MI)-associated pathological changes in the myocardium...
January 30, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338871/performance-measures-and-plasma-biomarker-levels-in-patients-with-multiple-sclerosis-after-14-days-of-fampridine-treatment-an-explorative-study
#30
JOURNAL ARTICLE
Maria Thorning, Kate Lykke Lambertsen, Henrik Boye Jensen, Lars Henrik Frich, Jonna Skov Madsen, Dorte Aalund Olsen, Anders Holsgaard-Larsen, Helle Hvilsted Nielsen
Peripheral cytokine levels may serve as biomarkers for treatment response and disease monitoring in patients with multiple sclerosis (pwMS). The objectives were to assess changes in plasma biomarkers in PwMS after 14 days of fampridine treatment and to explore correlations between changes in performance measures and plasma biomarkers. We included 27 PwMS, 14 women and 13 men, aged 52.0 ± 11.6 years, with a disease duration of 17 ± 8.5 years, and an Expanded Disability Status Scale of 6 [IQR 5.0/6...
January 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338686/gt-00axil15-a-novel-tumor-targeted-il-15-based-immunocytokine-for-the-treatment-of-ta-muc1-positive-solid-tumors-preclinical-in-vitro-and-in-vivo-pharmacodynamics-and-biodistribution-studies
#31
JOURNAL ARTICLE
Johanna Gellert, Anika Jäkel, Antje Danielczyk, Christoph Goletz, Timo Lischke, Anke Flechner, Laura Dix, Alexandra Günzl, Patrik Kehler
GT-00AxIL15 is a novel interleukin-15-based immunocytokine targeting a tumor-specific, glycosylated epitope of MUC1 (TA-MUC1). We characterized mode of action, pharmacokinetic (PK) and pharmacodynamic (PD) properties and investigated the relevance of TA-MUC1 binding for the concept of delivering IL-15 to solid tumors. In vitro pharmacology was analyzed in binding and cell-based assays. The in vivo PK profile and IL-15-mediated PD effects of GT-00AxIL15 were investigated in tumor-free mice. Tumor accumulation, immune infiltration and anti-tumor activity were assessed in TA-MUC1+ syngeneic and xenogeneic murine tumor models...
January 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338657/combined-use-of-tocilizumab-and-mesenchymal-stem-cells-attenuate-the-development-of-an-anti-hla-a2-1-antibody-in-a-highly-sensitized-mouse-model
#32
JOURNAL ARTICLE
Xianying Fang, Sheng Cui, Hanbi Lee, Ji Won Min, Sun Woo Lim, Eun-Jee Oh, Chul Woo Yang, Yoo Jin Shin, Byung Ha Chung
Sensitization to HLA can result in allograft loss for kidney transplantation (KT) patients. Therefore, it is required to develop an appropriate desensitization (DSZ) technique to remove HLA-donor-specific anti-HLA antibody (DSA) before KT. The aim of this research was to investigate whether combined use of the IL-6 receptor-blocking antibody, tocilizumab (TCZ), and bone-marrow-derived mesenchymal stem cells (BM-MSCs) could attenuate humoral immune responses in an allo-sensitized mouse model developed using HLA...
January 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38328140/vagus-nerve-stimulation-vns-modulates-synaptic-plasticity-in-the-rat-infralimbic-cortex-via-trk-b-receptor-activation-to-reduce-drug-seeking
#33
Christopher M Driskill, Jessica E Childs, Aarron J Phensy, Sierra R Rodriguez, John T O'Brien, Kathy L Lindquist, Aurian Naderi, Bogdan Bordieanu, Jacqueline F McGinty, Sven Kroener
UNLABELLED: Drugs of abuse cause changes in the prefrontal cortex (PFC) and associated regions that impair inhibitory control over drug-seeking. Breaking the contingencies between drug-associated cues and the delivery of the reward during extinction learning reduces relapse. Vagus nerve stimulation (VNS) has previously been shown to enhance extinction learning and reduce drug-seeking. Here we determined the effects of VNS-mediated release of brain-derived neurotrophic factor (BDNF) on extinction and cue-induced reinstatement in rats trained to self-administer cocaine...
January 26, 2024: bioRxiv
https://read.qxmd.com/read/38319525/hydroxysafflor-yellow-a-inhibits-pyroptosis-and-protecting-huvecs-from-ogd-r-via-nlrp3-caspase-1-gsdmd-pathway
#34
JOURNAL ARTICLE
Fan Guo, Xiao Han, Yue You, Shu-Juan Xu, Ye-Hao Zhang, Yuan-Yuan Chen, Gao-Jie Xin, Zi-Xin Liu, Jun-Guo Ren, Ce Cao, Ling-Mei Li, Jian-Hua Fu
OBJECTIVE: To observe the protective effect and mechanism of hydroxyl safflower yellow A (HSYA) from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells (HUVECs). METHODS: HUVECs were treated with oxygen-glucose deprivation reperfusion (OGD/R) to simulate the ischemia reperfusion model, and cell counting kit-8 was used to detect the protective effect of different concentrations (1.25-160 µ mol/L) of HSYA on HUVECs after OGD/R. HSYA 80 µ mol/L was used for follow-up experiments...
February 6, 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38317239/single-cell-analysis-reveals-alterations-in-cellular-composition-and-cell-cell-communication-associated-with-airway-inflammation-and-remodeling-in-asthma
#35
JOURNAL ARTICLE
Xiu Yu, Lifei Li, Bicheng Cai, Wei Zhang, Quan Liu, Nan Li, Xing Shi, Li Yu, Rongchang Chen, Chen Qiu
BACKGROUND: Asthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with abnormal responses of various cell types in the lung. The specific interactions between immune and stromal cells, crucial for asthma pathogenesis, remain unclear. This study aims to determine the key cell types and their pathological mechanisms in asthma through single-cell RNA sequencing (scRNA-seq). METHODS: A 16-week mouse model of house dust mite (HDM) induced asthma (n = 3) and controls (n = 3) were profiled with scRNA-seq...
February 5, 2024: Respiratory Research
https://read.qxmd.com/read/38317180/dynamics-of-host-immune-responses-and-a-potential-function-of-trem2-hi-interstitial-macrophages-in-pneumocystis-pneumonia
#36
JOURNAL ARTICLE
Hu-Qin Yang, Han Sun, Kang Li, Ming-Ming Shao, Kan Zhai, Zhao-Hui Tong
BACKGROUND: Pneumocystis pneumonia (PCP) is a life-threatening opportunistic fungal infection with a high mortality rate in immunocompromised patients, ranging from 20 to 80%. However, current understanding of the variation in host immune response against Pneumocystis across different timepoints is limited. METHODS: In this study, we conducted a time-resolved single-cell RNA sequencing analysis of CD45+ cells sorted from lung tissues of mice infected with Pneumocystis...
February 5, 2024: Respiratory Research
https://read.qxmd.com/read/38309959/-standard-technical-specifications-for-methacholine-chloride-methacholine-bronchial-challenge-test-2023
#37
JOURNAL ARTICLE
(no author information available yet)
The methacholine challenge test (MCT) is a standard evaluation method of assessing airway hyperresponsiveness (AHR) and its severity, and has significant clinical value in the diagnosis and treatment of bronchial asthma. A consensus working group consisting of experts from the Pulmonary Function and Clinical Respiratory Physiology Committee of the Chinese Association of Chest Physicians, the Task Force for Pulmonary Function of the Chinese Thoracic Society, and the Pulmonary Function Group of Respiratory Branch of the Chinese Geriatric Society jointly developed this consensus...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38287119/the-clarithromycin-binding-proteins-nipsnap1-and-2-regulate-cytokine-production-through-mitochondrial-quality-control
#38
JOURNAL ARTICLE
Soh Yamamoto, Noriko Ogasawara, Yukari Mitsuhashi, Kenichi Takano, Shin-Ichi Yokota
The mechanism underlying the anti-inflammatory effect of macrolide antibiotics, such as clarithromycin (CAM), remains to be clarified. The CAM-binding proteins 4-nitrophenylphosphatase domain and non-neuronal synaptosomal associated protein 25 (SNAP25)-like protein homolog (NIPSNAP) 1 and 2 are involved in the immune response and mitochondrial homeostasis. However, the axis between CAM-NIPSNAP-mitochondria and Toll-like receptor (TLR) and their molecular mechanisms remain unknown. In this study, we sought to elucidate the relationship between mitochondrial homeostasis mediated by NIPSNAP1 and 2 and the immunomodulatory effect of CAM...
January 29, 2024: Scientific Reports
https://read.qxmd.com/read/38285776/the-apoptotic-property-of-nymphaea-caerulea-flower-extract-on-acute-myeloid-leukaemia-cell-line-thp-1
#39
JOURNAL ARTICLE
Debasmita Chatterjee, Banhishikha Singh, Krishnendu Paira, Satadal Das
BACKGROUND: Acute Myeloid Leukaemia (AML) is considered to be an extremely heterogeneous malignancy of bone marrow and blood. The first line of therapy for AML is prolonged chemotherapy. Due to the presence of molecular heterogeneity in AML as confirmed by next-generation sequencing, researchers are planning to develop newer strategies of therapy. OBJECTIVE: In the present study we have explored the anti-cancer potentiality of the hydro-ethanolic extract (50% and 70%) of the whole flower of Nymphaea caerulea against the Acute Myeloid Leukaemia cell line, THP-1 with control of normal human kidney epithelial cell line (HEK 293)...
January 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38258051/immunomodulatory-effect-of-hypericin-mediated-photodynamic-therapy-on-oral-cancer-cells
#40
JOURNAL ARTICLE
Marcin Olek, Agnieszka Machorowska-Pieniążek, Zenon P Czuba, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka
In 2020, there were 377,713 new oral and lip cancer diagnoses and 177,757 deaths. Oral cancer is a malignancy of the head and neck region, and 90% of cases are squamous cell carcinomas (OSCCs). One of the alternative methods of treating pre-cancerous lesions and oral cancer is photodynamic therapy (PDT). In addition to the cytotoxic effect, an important mechanism of PDT action is the immunomodulatory effect. This study used the OSCC (SCC-25) cell line and the healthy gingival fibroblast (HGF-1) line. A compound of natural origin-hypericin (HY)-was used as the photosensitizer (PS)...
December 27, 2023: Pharmaceutics
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