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IL 25 receptor

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https://www.readbyqxmd.com/read/29687949/1-25-oh-2-d-3-inhibited-th17-cells-differentiation-via-regulating-the-nf-%C3%AE%C2%BAb-activity-and-expression-of-il-17
#1
Dong Sun, Fei Luo, Jun-Chao Xing, Fei Zhang, Jian-Zhong Xu, Ze-Hua Zhang
OBJECTIVES: The role of vitamin D (VD) in innate and adaptive immune responses to tuberculosis is still unclear. Our research was aimed to uncover the effect of VD on Th17 cells and elucidate potential molecular mechanism. MATERIALS AND METHODS: VDR-deficient and wild-type mice were used to obtain CD4 T cells. Th17 cells were induced and activated by Bacillus Calmette Guerin. Flow cytometry was used to analyse the apoptosis rate and degree of differentiation of Th17 cells in the treatment of 1,25(OH)2 D3 ...
April 24, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29676068/trpv1-blocking-alleviates-airway-inflammation-and-remodeling-in-a-chronic-asthma-murine-model
#2
Joon Young Choi, Hwa Young Lee, Jung Hur, Kyung Hoon Kim, Ji Young Kang, Chin Kook Rhee, Sook Young Lee
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1 (TRPV1) channel in the pathophysiology of asthma. This study examined whether TRPV1 antagonism alleviates asthma features in a murine model of chronic asthma. METHODS: BALB/c mice were sensitized to and challenged by ovalbumin to develop chronic asthma...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29672862/aryl-hydrocarbon-receptor-activation-by-diesel-exhaust-particles-mediates-epithelium-derived-cytokines-expression-in-severe-allergic-asthma
#3
Chih-Ming Weng, Chun-Hua Wang, Meng-Jung Lee, Jung-Re He, Hsin-Yu Huang, Ming-Wei Chao, Kian Fan Chung, Han-Pin Kuo
BACKGROUND: Exposure to environmental pollutants promotes Th2 cell responses. Aryl hydrocarbon receptor (AhR) activation aggravates allergic responses. Epithelium-derived thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33 are implicated in the dysregulation of Th2 immune responses in severe allergic asthma. METHODS: Bronchial biopsies of 28 allergic severe asthma and 6 mild asthma subjects from highly polluted areas were analyzed for AhR nuclear translocation (NT), cytokine expression and gene activation...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29662482/targeting-mycobacterium-tuberculosis-antigens-to-dendritic-cells-via-the-dc-specific-icam3-grabbing-nonintegrin-receptor-induces-strong-t-helper-1-immune-responses
#4
Lis Noelia Velasquez, Philipp Stüve, Maria Virginia Gentilini, Maxine Swallow, Judith Bartel, Nils Yngve Lycke, Daniel Barkan, Mariana Martina, Hugo D Lujan, Hakan Kalay, Yvette van Kooyk, Tim D Sparwasser, Luciana Berod
Tuberculosis remains a major global health problem and efforts to develop a more effective vaccine have been unsuccessful so far. Targeting antigens (Ags) to dendritic cells (DCs) in vivo has emerged as a new promising vaccine strategy. In this approach, Ags are delivered directly to DCs via antibodies that bind to endocytic cell-surface receptors. Here, we explored DC-specific-ICAM3-grabbing-nonintegrin (DC-SIGN) targeting as a potential vaccine against tuberculosis. For this, we made use of the hSIGN mouse model that expresses human DC-SIGN under the control of the murine CD11c promoter...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29661181/tlr4-modulates-inflammatory-gene-targets-in-the-retina-during-bacillus-cereus-endophthalmitis
#5
Phillip S Coburn, Frederick C Miller, Austin L LaGrow, Salai Madhumathi Parkunan, C Blake Randall, Rachel L Staats, Michelle C Callegan
BACKGROUND: Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation during endophthalmitis, more rational targets are needed. Toll-like receptors (TLRs) recognize specific motifs on invading pathogens and initiate the innate inflammatory response. We reported that TLR4 contributes to the robust inflammation which is a hallmark of Bacillus cereus endophthalmitis...
April 16, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29659888/randomized-placebo-controlled-trial-to-evaluate-effects-of-eplerenone-on-metabolic-and-inflammatory-indices-in-hiv
#6
Suman Srinivasa, Kathleen V Fitch, Kimberly Wong, Timothy K O'Malley, Patrick Maehler, Karen L Branch, Sara E Looby, Tricia H Burdo, Edgar L Martinez-Salazar, Martin Torriani, Shannon H Lyons, Julian Weiss, Meghan Feldpausch, Takara L Stanley, Gail K Adler, Steven K Grinspoon
Context: HIV-infected individuals demonstrate unique RAAS physiology, with increased RAAS activation in association with visceral adiposity, insulin resistance, and inflammation. A physiologically-based treatment approach targeting mineralocorticoid receptor (MR) blockade may improve metabolic and inflammatory indices in HIV. Objective: To investigate effects of eplerenone on insulin sensitivity, inflammatory indices and other metabolic parameters in HIV. Design: Six month, double-blind, randomized, placebo-controlled trial...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29643997/new-antimicrobial-peptide-kills-drug-resistant-pathogens-without-detectable-resistance
#7
Jong-Kook Lee, Tudor Luchian, Yoonkyung Park
Clavaspirin peptide (CSP) is derived from the pharyngeal tissues of the tunicate Styela clava . The 23-amino acid peptide is histidine-rich and amidated at the N-terminus. CSP possesses low antimicrobial and high hemolytic activity at pH 7.4. Therefore, we designed 4 CSP analogs with substituted hydrophobic amino acids to reduce hydrophobic amino acid interactions. These modifications reduced the aggregation and cytotoxicity of the analogs at pH 7.4. The analogs also showed potent antimicrobial activity by accumulating on bacterial cell surfaces and inducing the lytic mechanism against gram-negative and gram-positive cells at pH 5...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29627302/inhibitive-effect-of-resveratrol-on-the-inflammation-in-cultured-astrocytes-and-microglia-induced-by-a%C3%AE-1-42
#8
Haifeng Zhao, Qian Wang, Xuejiao Cheng, Xuemin Li, Na Li, Tiantian Liu, Jing Li, Qian Yang, Ruirui Dong, Yusen Zhang, Luping Zhang
Astrocytes and microglia appear central to the initiation and progression of neuroinflammation in Alzheimer's disease (AD). In this study, inflammation was mimicked by Aβ1-42 treatment of rat astrocytes (RA) and N9 microglia cell lines. Inflammation induced by Aβ1-42 can be inhibited by pyrrolidinedithiocarbamicacid (PDTC), indicating that the NF-κB signal pathway is involved in the inflammation. Then, the inhibitive effects of resveratrol (Res) on the inflammation in RA and N9 cells were assessed by observing the changes in inflammatory factors, chemokines, cell cycle and adhesion molecules on the cell surface...
April 5, 2018: Neuroscience
https://www.readbyqxmd.com/read/29624921/a-genetic-variant-in-il-15r%C3%AE-correlates-with-physical-activity-among-european-american-adults
#9
Michael Bruneau, Sean Walsh, Eric Selinsky, Garrett Ash, Theodore J Angelopoulos, Priscilla Clarkson, Paul Gordon, Niall Moyna, Paul Visich, Robert Zoeller, Paul Thompson, Heather Gordish-Dressman, Eric Hoffman, Joseph Devaney, Linda S Pescatello
BACKGROUND: Interleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults. METHODS: Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m2 ) and women (n = 292, 23...
April 6, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29609579/euterpe-oleracea-extract-inhibits-tumorigenesis-effect-of-the-chemical-carcinogen-dmba-in-breast-experimental-cancer
#10
Jéssica Alessandra-Perini, Jamila Alessandra Perini, Karina Cristina Rodrigues-Baptista, Roberto Soares de Moura, Antonio Palumbo Junior, Thiago Alves Dos Santos, Pergentino José Cunha Souza, Luiz Eurico Nasciutti, Daniel Escorsim Machado
BACKGROUND: Among the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) and macrophages. Recently, the extract of Euterpe oleracea (açaí), a fruit that is widely found in the Amazon region, already showed antitumorigenic effects in vitro in human breast cancer cell lines. The present study aimed to investigate the effect of açaí on breast cancer using a chemically DMBA (7,12-dimethylbenzanthracene) experimental model...
April 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29609271/-killing-effect-of-robo1-targeted-chimeric-antigen-receptor-modified-nk92-cells-against-glioma-and-neuroblastoma-cells
#11
Y Qu, J Z Bi
Objective: To study the cytotoxicity of Robo1-CAR-NK92 cells against U87-MG and SH-SY5Y cells, to explore the effects of IL-15, IL-21 and dexamethasone on the proliferation, survival and cytotoxicity of Robo1-CAR-NK92 cells and to optimize the culture protocol. Methods: Robo1-CAR-NK92 cells were constructed by lentivirus transfection.The Robo1 car positive cells were sorted, expanded and detected by flow cytometry.The levels of Robo1 expression in SH-SY5Y and U87-MG cells were examined by flow cytometry.The cytotoxicity of Robo1-CAR-NK92 or NK92 cells against target cells was tested by CCK-8 and live cell imaging...
March 20, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29608910/pre-clinical-and-translational-pharmacology-of-a-human-interleukin-22-igg-fusion-protein-for-potential-treatment-of-infectious-or-inflammatory-diseases
#12
Eric G Stefanich, Julie Rae, Siddharth Sukumaran, Jeff Lutman, Annemarie Lekkerkerker, Wenjun Ouyang, Xiaoting Wang, Donna Lee, Dimitry M Danilenko, Lauri Diehl, Kelly M Loyet, Ann Herman
Interleukin (IL)-22 plays protective roles in infections and in inflammatory diseases that have been linked to its meditation of innate immunity via multiple mechanisms. IL-22 binds specifically to its heterodimeric receptor, which is expressed on a variety of epithelial tissues. UTTR1147A is a recombinant fusion protein that links the human cytokine IL-22 with the Fc portion of human immunoglobulin (Ig) G4. Here, we report extensive in vitro and in vivo nonclinical studies that were conducted to characterize the pharmacological activity of UTTR1147A...
March 30, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29604137/immunomodulatory-effect-of-artemisia-argyi-polysaccharide-on-peripheral-blood-leucocyte-of-broiler-chickens
#13
P Zhang, B Shi, T Li, Y Xu, X Jin, X Guo, S Yan
This study was conducted to investigate the immunomodulatory effect of a water-soluble polysaccharide extracted from Artemisia argyi (AAP) in vitro. The effect was assessed in peripheral blood leucocytes (PBLs) of broilers, which were incubated with different AAP concentrations (0, 25, 50, 100, and 200 μg/ml) for 24 hr at 37°C in a 5% CO2 incubator. The results showed that, compared with the control group, immunoglobulin M (IgM) concentration was increased in the supernatant of the 100 μg/ml AAP-treated group (p < ...
March 31, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29594257/plasma-il-1-receptor-antagonist-concentration-has-an-inverse-association-with-birth-weight-in-prepubertal-children
#14
Henrikki Nordman, Raimo Voutilainen, Leena Antikainen, Jarmo Jääskeläinen
Context: Birth size has an impact on later cardiometabolic risk that is strongly related to low-grade inflammation. Objective: To evaluate plasma interleukin-1 receptor antagonist (IL-1ra) concentrations in relation to birth size and cardiometabolic and inflammatory markers in prepubertal children. Design: A cohort study. Anthropometric data were recorded. Fasting blood samples were collected for plasma analyses of IL-1ra, alanine transaminase, total cholesterol, high- and low-density lipoprotein cholesterols, triglyceride, glucose, and serum analyses of 25-hydroxyvitamin D [25(OH)D] and high-sensitivity C-reactive protein (hs-CRP) concentrations...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29584788/il-17a-il-17rc-polymorphisms-and-il17-plasma-levels-in-tunisian-patients-with-rheumatoid-arthritis
#15
Tarak Dhaouadi, Mayssa Chahbi, Youssra Haouami, Imen Sfar, Leila Abdelmoula, Taieb Ben Abdallah, Yousr Gorgi
BACKGROUND: Interleukin-17 (IL-17), a cytokine mainly secreted by Th17 cells, seems to play a significant role in the pathogenesis of rheumatoid arthritis (RA). Functional genetic polymorphisms in IL-17 and its receptor genes can influence either qualitatively or quantitatively their functions. Therefore, we aimed to study the impact of IL17-A and IL17RC polymorphisms on plasma level of IL-17 and RA susceptibility and severity. METHODS: In this context, IL-17A*rs2275913 and IL-17RC*rs708567 polymorphisms were investigated together with the quantification of IL17 plasma level in 115 RA patients and 91 healthy control subjects matched in age, sex and ethnic origin...
2018: PloS One
https://www.readbyqxmd.com/read/29577184/endogenous-regulators-of-the-immune-system-scd100-malonic-dialdehyde-and-arginase
#16
A N Kazimirskii, G V Poryadin, Zh M Salmasi, L Yu Semenova
Tissue damage in various diseases, hypoxic conditions, and some pathologies are associated with production of endogenous factors such as the soluble form of the surface receptor CD100, malonic dialdehyde, and arginase and their release into circulation. These factors modulate functional state of lymphocytes in the immune system: potentiate activation of B lymphocytes, activate synthesis and secretion of IL-25 and IL-17 cytokines, and suppress proliferative activity of T lymphocytes, thus modulating immunological reactivity of the organism...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29558888/the-serum-based-veristrat%C3%A2-test-is-associated-with-proinflammatory-reactants-and-clinical-outcome-in-non-small-cell-lung-cancer-patients
#17
Mary Jo Fidler, Cristina L Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi, Jeffrey A Borgia
BACKGROUND: The VeriStrat test is a serum proteomic signature originally discovered in non-responders to second line gefitinib treatment and subsequently used to predict differential benefit from erlotinib versus chemotherapy in previously treated advanced non-small cell lung cancer (NSCLC). Multiple studies highlight the clinical utility of the VeriStrat test, however, the mechanistic connection between VeriStrat-poor classification and poor prognosis in untreated and previously treated patients is still an active area of research...
March 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29525270/evaluation-of-murine-lung-epithelial-cells-tc-1-jhu-1-line-to-develop-th2-promoting-cytokines-il-25-il-33-tslp-and-genes-tlr2-tlr4-in-response-to-aspergillus-fumigatus
#18
A R Khosravi, H Shokri, S Hassan Al-Heidary, F Ghafarifar
OBJECTIVE: The aims of this study were to determine the role of live and heat-killed Aspergillus fumigatus conidia in releasing interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP) and to express Toll-like receptor (Tlr)2 and Tlr4 genes. MATERIALS AND METHODS: Murine lung epithelial cells were incubated with live and heat-killed A. fumigatus conidia at 37°C for 6, 24 and 48h. After treatments, ELISA was performed to measure the concentrations of IL-25, IL-33 and TSLP in the supernatants...
March 7, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29522785/vitamin-d3-inhibits-the-proliferation-of-t-helper-cells-downregulate-cd4-t-cell-cytokines-and-upregulate-inhibitory-markers
#19
Vida Sheikh, Pinar Kasapoglu, Alireza Zamani, Zahra Basiri, Ahmad Tahamoli-Roudsari, Mahdi Alahgholi-Hajibehzad
1 α, 25-dihydroxyvitamin D3 (VitD3) has been suggested to have strong modulatory properties in the immune system. Researchers in the present study primarily aimed to understand the effect of VitD3 on human CD4+ T cell proliferation in antigen presenting cells (APCs) free condition in vitro. The effect of VitD3 on intracellular cytokine responses trend to Th1, Th2, Th17 and Th22 was evaluated using the flow cytometry. Moreover the effect of VitD3 on the expression of inhibitory markers such as PD1, PD-L1, and CTLA4 which are induced upon polyclonal T cell receptor (TCR) activation on CD4+ T cells, was assessed...
March 6, 2018: Human Immunology
https://www.readbyqxmd.com/read/29500135/pharmacokinetics-and-pharmacodynamics-of-intravesical-and-intravenous-tmx-101-and-tmx-202-in-a-f344-rat-model
#20
Johannes Falke, Christina A Hulsbergen-van de Kaa, Roberto Maj, Egbert Oosterwijk, Johannes Alfred Witjes
OBJECTIVES: To evaluate and compare the pharmacokinetic and pharmacodynamic properties of 2 investigational Toll-like receptor 7 agonists, TMX-101, and TMX-202 after intravenous and intravesical administration in a rat model. TLR-7 agonists are successfully used as topical treatment for various (pre)malignant skin lesions and are now under investigation as intravesical therapy for non-muscle-invasive bladder cancer. METHODS: Rats received an intravesical instillation with TMX-101, TMX-202, or vehicle...
February 27, 2018: Urologic Oncology
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