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IL 25 receptor

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https://www.readbyqxmd.com/read/29465363/inhibitory-effect-and-mechanism-of-1-25-dihydroxy-vitamin-d3-on-rankl-expression-in-fibroblast-like-synoviocytes-and-osteoclast-like-cell-formation-induced-by-il-22-in-rheumatoid-arthritis
#1
Hongyan Wen, Yang Liu, Jinchan Li, Dandan Wei, Dandan Liu, Fangfang Zhao
OBJECTIVES: To explore the inhibitory effect and mechanism of 1,25-dihydroxy vitamin D3 (l,25(OH)2D3) on receptor activator of nuclear factor-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLSs) and osteoclastogenesis induced by interleukin (IL)-22 in patients with rheumatoid arthritis (RA). METHODS: Fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLSs) were cultured and stimulated for RANKL expression with IL-22 in the absence or presence of various concentrations of l,25(OH)2D3, and JAK-2 inhibitor or p38 MAPK inhibitor at the optimised time point of IL-22 treatment...
February 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29465346/il-6-receptor-inhibition-modulates-type-iii-collagen-and-c-reactive-protein-degradation-in-rheumatoid-arthritis-patients-with-an-inadequate-response-to-anti-tumour-necrosis-factor-therapy-analysis-of-connective-tissue-turnover-in-the-tocilizumab-radiate
#2
Pernille Juhl, Christian S Thudium, Natasja S Gudmann, Morten A Karsdal, Anne-Christine Bay-Jensen, Anne Sofie Siebuhr
OBJECTIVES: The objective of this study was to examine the tissue degradation in response to anti-IL6 receptor treatment in rheumatoid arthritis (RA) patients which are anti-TNF-α inadequate responders. METHODS: RADIATE was a randomised, double-blinded, placebo-controlled, parallel-group, phase III trial. RA patients with previous inadequate response to anti-TNFα therapy (n=299) were randomly assigned to tocilizumab 4 or 8 mg/kg with methotrexate (10-25 mg weekly) or placebo with methotrexate...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29456832/interleukin-25-and-eosinophils-progenitor-cell-mobilization-in-allergic-asthma
#3
Wei Tang, Steven G Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M Salter, Gail M Gauvreau, Paul M O'Byrne, Roma Sehmi
Background: Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways. Sputum levels of EoP are increased in asthmatics compared to normal controls suggesting an exaggerated eosinophilopoietic environment in the airways. Understanding what factors promote EoP traffic to the airways is important to understand the diathesis of asthma pathology...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29450537/enhanced-expression-of-nlrp3-inflammasome-related-inflammation-in-diabetic-retinopathy
#4
Hui Chen, Xiongze Zhang, Nanying Liao, Lan Mi, Yuting Peng, Bing Liu, Shaochong Zhang, Feng Wen
Purpose: The aim of this study was to determine the association between nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation and disease severity in diabetic retinopathy (DR). Methods: Blood samples were collected from 64 patients with diabetes (DR, 43; without DR, 21) and 25 healthy controls. The protein and mRNA expression levels of NLRP3 inflammasomes in peripheral blood mononuclear cells were determined using western blotting and quantitative real-time reverse transcription-PCR...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29439934/suppressed-networks-of-inflammatory-mediators-characterize-chronic-venous-insufficiency
#5
Ulka Sachdev, Lena Vodovotz, Julie Bitner, Derek Barclay, Ruben Zamora, Jinling Yin, Richard L Simmons, Yoram Vodovotz
OBJECTIVE: Chronic venous insufficiency (CVI) affects 25 million adults in the United States. Little emphasis has been placed on inflammatory changes associated with CVI. We hypothesize that in patients with early to mid-stage benign varicose vein disease, differences in circulating inflammatory mediators will be manifested in blood draining the involved area vs circulating blood in control subjects. METHODS: Patients undergoing either endovenous ablation or sclerotherapy for Clinical, Etiology, Anatomy, and Pathophysiology clinical class 3 to 5 disease underwent phlebotomy from regional veins at the time of the procedure...
February 10, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29434775/il-25-promotes-th2-bias-by-upregulating-il-4-and-il-10-expression-of-decidual-%C3%AE-%C3%AE-t-cells-in-early-pregnancy
#6
Yuan Zhang, Ying Wang, Ming-Qing Li, Jie Duan, Deng-Xuan Fan, Li-Ping Jin
Decidual immune cells (DICs), consisting of both innate and adaptive immune cells, have a pivotal role in maintaining immune tolerance for normal pregnancy. Our previous study demonstrated that interleukin (IL)-25 stimulates the proliferation of decidual stromal cells (DSCs) in an autocrine manner. However, the role of IL-25 in functional regulation of DICs is largely unknown. Flow cytometry was used to analyze the expression of IL-25 and its receptor (IL-17RB) in DICs, and the effect of IL-25 on the expression of Ki-67, IL-4, IL-10, interferon (IFN)-γ and transforming growth factor (TGF)-β in decidual γδT cells...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29427987/advances-and-evolving-concepts-in-allergic-asthma
#7
Hui-Ying Tung, Evan Li, Cameron Landers, An Nguyen, Farrah Kheradmand, J Morgan Knight, David B Corry
Allergic asthma is a heterogeneous disorder that defies a unanimously acceptable definition, but is generally recognized through its highly characteristic clinical expression of dyspnea and cough accompanied by clinical data that document reversible or exaggerated airway constriction and obstruction. The generally rising prevalence of asthma in highly industrialized societies despite significant therapeutic advances suggests that the fundamental cause(s) of asthma remain poorly understood. Detailed analyses of both the indoor (built) and outdoor environments continue to support the concept that not only inhaled particulates, especially carbon-based particulate pollution, pollens, and fungal elements, but also many noxious gases and chemicals, especially biologically derived byproducts such as proteinases, are essential to asthma pathogenesis...
February 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29409499/mechanisms-of-multiple-neurotransmitters-in-the-effects-of-lycopene-on-brain-injury-induced-by-hyperlipidemia
#8
Weichun Yang, Ziyi Shen, Sixian Wen, Wei Wang, Minyu Hu
BACKGROUND: Lycopene is a kind of carotenoid, with a strong capacity of antioxidation and regulating the bloodlipid. There has been some evidence that lycopene has protective effects on the central nervous system, but few studies have rigorously explored the role of neurotransmitters in it. Therefore, the present study was designed to investigate the effects of several neurotransmitters as lycopene exerts anti-injury effects induced by hyperlipidemia. METHODS: Eighty adult SD rats, half male and half female, were randomly divided into eight groups on the basis of serum total cholesterol (TC) levels and body weight...
February 7, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29408715/single-cell-profiling-of-peanut-responsive-t-cells-in-peanut-allergic-subjects-reveals-heterogeneous-effector-th2-subsets
#9
David Chiang, Xintong Chen, Stacie M Jones, Robert A Wood, Scott H Sicherer, A Wesley Burks, Donald Y M Leung, Charuta Agashe, Alexander Grishin, Peter Dawson, Wendy F Davidson, Leah Newman, Robert Sebra, Miriam Merad, Hugh A Sampson, Bojan Losic, M Cecilia Berin
BACKGROUND: The contribution of phenotypic variation of peanut-specific T cells to clinical allergy or tolerance to peanut is not well understood. OBJECTIVES: Our objective was to comprehensively phenotype peanut-specific T cells in the peripheral blood of individuals with and without peanut allergy (PA). METHODS: We obtained samples from PA individuals, including a cohort undergoing baseline peanut challenges for an immunotherapy trial (CoFAR6)...
January 30, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29402810/basophil-membrane-expression-of-epithelial-cytokine-receptors-in-patients-with-severe-asthma
#10
Monica Boita, Enrico Heffler, Paola Omedè, Michela Bellocchia, Claudia Bussolino, Paolo Solidoro, Veronica Giorgis, Francesco Guerrera, Giuseppe Riva, Luisa Brussino, Caterina Bucca, Giovanni Rolla
BACKGROUND: Severe asthma is a heterogeneous disease, which is characterized by airway damage and remodeling. All triggers of asthma, such as allergens, bacteria, viruses, and pollutants, interact with the airway epithelial cells, which drive the airway inflammatory response through the release of cytokines, particularly IL-25, IL-33, and thymic stromal lymphopoietin (TSLP). OBJECTIVES AND METHODS: To investigate whether the expression of the IL-25, IL-33, and TSLP receptors on the basophil membrane are associated with asthma severity...
February 3, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29402365/-effect-and-mechanism-of-dexmedetomidine-on-lungs-in-patients-of-sepsis-complicated-with-acute-respiratory-distress-syndrome
#11
Xianfeng Chen, Juntao Hu, Chi Zhang, Yiping Pan, Diansheng Tian, Fafa Kuang, Zhanhong Tang
OBJECTIVE: To investigate the mechanisms of protective effects of dexmedetomidine on lungs in patients of sepsis complicated with acute respiratory distress syndrome (ARDS). METHODS: The adult patients with sepsis complicated with ARDS, the oxygenation index (PaO2/FiO2) was 150-200 mmHg (1 mmHg = 0.133 kPa), acute physiology and chronic health evaluation II (APACHE II) score was 10-20, need mechanical ventilation (MV) treatment > 72 hours, and admitted to intensive care unit (ICU) of the First Affiliated Hospital of Guangxi Medical University from September 2013 to June 2017 were enrolled...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29402356/-brl-44408-maleate-the-antagonist-of-%C3%AE-2a-adrenoceptor-attenuates-endogenous-lipopolysacchride-induced-acute-lung-injury-through-inhibiting-the-mitogen-activated-protein-kinase-kinase-extracellular-regulated-protein-kinases-signaling-pathway-in-mice
#12
Xiangpeng Lyu, Zhukai Cong, Yifan Tao, Dan Li, Xi Zhu
OBJECTIVE: To explore the effects and mechanism of α2A-adrenergic receptor (α2A-AR) antagonist BRL-44408 maleate on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. METHODS: Sixty male C57BL/6 mice were randomly divided into three groups (n = 20): sham group, LPS group and BRL-44408 maleate pre-treated group (BRL+LPS group). The model of ALI was replicated by intratracheally administrated of LPS (5 mg/kg), and the mice in the sham group were received an equal volume of saline...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29399397/il-25-dampens-the-growth-of-human-germinal-center-derived-b-cell-non-hodgkin-lymphoma-by-curtailing-neoangiogenesis
#13
Elisa Ferretti, Emma Di Carlo, Emanuela Ognio, Giulio Fraternali-Orcioni, Anna Corcione, Beatrice Belmonte, Jean Louis Ravetti, Claudio Tripodo, Domenico Ribatti, Vito Pistoia
Interleukin (IL)-25, a member of the IL-17 cytokine superfamily, is produced by immune and non-immune cells and exerts type 2 pro-inflammatory effects in vitro and in vivo. The IL-25 receptor(R) is composed of the IL-17RA/IL-17RB subunits. Previous work showed that germinal centre (GC)-derived B-cell non Hodgkin lymphomas (B-NHL) expressed IL-17AR, formed by IL-17RA and IL-17RC subunits, and IL-17A/IL-17AR axis promoted B-NHL growth by stimulating neoangiogenesis. Here, we have investigated expression and function of IL-25/IL-25R axis in lymph nodes from human GC-derived B-NHL, i...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29395365/prognostic-impact-of-interleukin-1-receptor-antagonist-in-patients-with-documented-coronary-artery-disease
#14
Niklas Schofer, Sebastian Ludwig, Nicole Rübsamen, Renate Schnabel, Karl J Lackner, Hans J Ruprecht, Christoph Bickel, Ulf Landmesser, Stefan Blankenberg, Tanja Zeller
BACKGROUND: IL-1β-mediated inflammation contributes to development and progression of coronary artery disease (CAD). We aimed to assess the prognostic impact of the inflammatory marker Interleukin-1 receptor antagonist (IL1-Ra), reflecting high IL-1β activity, in patients with documented CAD. METHODS: IL-1Ra levels were determined in 1337 subjects of the AtheroGene study, a prospective cardiovascular registry comprising patients with CAD as detected by coronary angiography presenting with acute coronary syndrome (ACS) or stable angina...
January 29, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29387386/body-condition-score-prior-to-parturition-is-associated-with-plasma-and-adipose-tissue-biomarkers-of-lipid-metabolism-and-inflammation-in-holstein-cows
#15
Abdulrahman Alharthi, Zheng Zhou, Vincenzo Lopreiato, Erminio Trevisi, Juan J Loor
Background: Previous research has revealed a strong inflammatory response within adipose (AT) tissue during the transition into lactation. Whether this effect is a result of oxidative stress induced by lipolysis and fatty acid oxidation associated with differences in prepartum body condition score remains to be determined. The objectives of this study were to investigate systemic biomarkers of energy balance and inflammation and the expression of lipid metabolism- and inflammation-related genes in AT during the transition period in dairy cows...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29384117/vitamin-d-receptor-variants-and-uncontrolled-asthma
#16
K Hutchinson, C P Kerley, J Faul, P Greally, D Coghlan, M Louw, B Elnazir, Y Rochev
Background. Asthma is a common childhood respiratory disease, affecting around 20% of Irish children. In other populations, vitamin D receptor (VDR) polymorphisms have been associated with asthma risk. We aimed to investigate the association between 2 VDR polymorphisms and uncontrolled paediatric asthma. Methods. 44 asthmatic children and 57 healthy volunteers were studied. The VDR TaqI gene variant in exon 9 (T/C) (rs731236) and ApaI (rs7975232) in intron 8 (C/T) were determined, using TaqMan® Assays. The lung function, serum 25-hydroxyvitamin D (25OHD) levels and other biomarkers of allergy, immunity, airway and systemic inflammation were as-sessed...
November 28, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383579/selenium-na2seo3-upregulates-expression-of-immune-genes-and-blood-testis-barrier-constituent-proteins-of-bovine-sertoli-cell-in-vitro
#17
E O Adegoke, Xue Wang, Hao Wang, Chen Wang, Han Zhang, Guixue Zhang
Sertoli cells were isolated from newborn calves and cultured in a medium supplemented with 0, 0.25, 0.50, 0.75, and 1.00 mg/L of sodium selenite to study their immune stimulatory effect, influence on cell's viability, and expression of blood-testis barrier proteins (occludin, connexin-43, zonula occluden, E-cadherin) using quantitative PCR and western blot analyses. Results showed that medium supplemented with 0.50 mg/L of selenium significantly (P < 0.05) promoted cell viability, upregulated toll-like receptor gene (TLR4), anti-inflammatory cytokines (IL-4, IL-10, TGFβ1), and expressions of blood-testis barrier proteins, and modulated expressions of pro-inflammatory cytokines (TNF-α, IL-1β, IFN-γ)...
January 31, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29380012/lymphocyte-surface-markers-and-cytokines-are-suitable-for-detection-and-potency-assessment-of-skin-sensitizing-chemicals-in-an-in-vitro-model-of-allergic-contact-dermatitis-the-lcsa-ly
#18
Janna Frombach, Anna Sonnenburg, Björn-Dirk Krapohl, Torsten Zuberbier, Matthias Peiser, Ralf Stahlmann, Maximilian Schreiner
Allergic contact dermatitis is a widespread health disorder and occupational skin disease. Hence, screening for contact-sensitizing chemicals is highly relevant to toxicology, dermatology, and occupational medicine. The use of animal tests for this purpose is constrained by ethical considerations, need for high-throughput screening, and legislation (e.g., for cosmetics in the European Union). T cell activation is the final and most specific key event of the "adverse outcome pathway" for skin sensitization and therefore a promising target for the development of in vitro sensitization assays...
January 30, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29360942/il-6-trans-activation-contributes-to-aldosterone-induced-cardiac-fibrosis
#19
Chia-Hung Chou, Chi-Sheng Hung, Che-Wei Liao, Lin-Hung Wei, Ching-Way Chen, Chia-Tung Shun, Wen-Fen Wen, Cho-Hua Wan, Xue-Ming Wu, Yi-Yao Chang, Vin-Cent Wu, Kwan-Dun Wu, Yen-Hung Lin
Aims: An excess of aldosterone results in cardiac remodeling and fibrosis. Interleukin-6 (IL-6) is a key mediator in the fibrotic process, however the effect of aldosterone on the expression of IL-6 remains unclear. We investigated whether aldosterone induces the expression of IL-6 and thereby contributes to the fibrotic process. Methods and Results: In this clinical study, we prospectively enrolled 25 patients with primary aldosteronism (PA) and 26 patients with essential hypertension (EH)...
January 19, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29356901/glycine-enhances-expression-of-adiponectin-and-il-10-in-3t3-l1-adipocytes-without-affecting-adipogenesis-and-lipolysis
#20
Jingqing Chen, Xiaoshi Ma, Ying Yang, Zhaolai Dai, Zhenlong Wu, Guoyao Wu
Glycine supplementation has been reported to enhance white-fat loss and improve sensitivity to insulin in animals with obesity or type 2 diabetes. However, the underlying mechanisms responsible for the beneficial effects of glycine remain largely unknown. The purpose of this study was to test the hypothesis that glycine regulates adipocyte differentiation, adipogenesis, and lipolysis, therefore, contributing to white-fat reduction. 3T3-L1 pre-adipocytes were induced to differentiate into adipocytes in the presence of glycine (0, 0...
January 22, 2018: Amino Acids
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