Yui-Hsi Wang, Pornpimon Angkasekwinai, Ning Lu, Kui Shin Voo, Kazuhiko Arima, Shino Hanabuchi, Andreas Hippe, Chris J Corrigan, Chen Dong, Bernhard Homey, Zhengbin Yao, Sun Ying, David P Huston, Yong-Jun Liu
Interleukin (IL) 25 (IL-17E), a distinct member of the IL-17 cytokine family, plays important roles in evoking T helper type 2 (Th2) cell-mediated inflammation that features the infiltrations of eosinophils and Th2 memory cells. However, the cellular sources, target cells, and underlying mechanisms remain elusive in humans. We demonstrate that human Th2 memory cells expressing distinctive levels of IL-25 receptor (R) are one of the responding cell types. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)-activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering...
August 6, 2007: Journal of Experimental Medicine