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https://www.readbyqxmd.com/read/29165309/clinical-characteristics-of-patients-with-dizziness-after-motor-vehicle-accident
#1
Min Bum Kim, Suk Won Chang, Gil Chai Lim, Chan Il Song
OBJECTIVE: The purpose of this study was to identify the clinical characteristics of dizziness occurring after a motor vehicle accident. MATERIALS AND METHODS: We retrospectively analyzed 217 patients who had visited a tertiary medical center complaining of dizziness after a motor vehicle accident between January 2009 and December 2014. Of the 217 patients, we enrolled 54 patients who had undergone a vestibular function test and had no definite evidence of fracture of the temporal bone or intracranial lesions...
November 21, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29164173/factors-related-to-the-severity-of-delirium-in-the-elderly-patients-with-infection
#2
R A Tuty Kuswardhani, Yosef Samon Sugi
Objective: Delirium is a common neuropsychiatric syndrome in the elderly characterized by concurrent impairments in cognition and behavior. Infection is one of the most important risk factors for delirium. The objective of this study is to elaborate the factors related to the severity of delirium in the elderly patients with infection. Method: An observational study on the relationship of several clinical parameters and the severity of delirium in elderly patients (more than 60 years) with infection was conducted at Geriatric Inpatient Ward, Sanglah Hospital...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29162452/dt-13-ameliorates-tnf-%C3%AE-induced-nitric-oxide-production-in-the-endothelium-in-vivo-and-in-vitro
#3
Ruiping Fan, Yuwei Han, Han Han, Zhengdong Chen, Boyang Yu, Junping Kou, Yuanyuan Zhang
The steroidal saponin DT-13 (25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1 → 2)][β-d-xylopyranosyl-(1 → 3)]-β-d-fucopyranoside), one of the major active compounds of the herb Liriope muscari (Decne.), exhibits significant anti-inflammatory, anti-tumour and cardioprotective effects. This study aimed to explore the protective effect of DT-13 on endothelium through regulating of nitric oxide production induced by TNF-α. The results demonstrated that DT-13 inhibits inflammatory cell infiltration and thus plays a protective effect, as shown by H&E staining and immunohistochemical staining...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29160418/vitamin-d3-levels-and-nlrp3-expression-in-murine-models-of-obese-asthma-association-with-asthma-outcomes
#4
J-H Zhang, Y-P Chen, X Yang, C-Q Li
Vitamin D (25(OH)D3) is an essential nutrient that plays a role in the immune system. Serum 25(OH)D3 is found to be associated with asthma. However, the role of vitamin D in obese asthma remains unclear. Therefore, we investigated the association between vitamin D levels and asthma outcomes in a murine model of obese asthma. We also evaluated NLRP3 inflammasome activity in the pathogenesis of obese asthma. We divided 20 male Balb/c mice (3-4 weeks old) into 4 groups: normal control, asthma, obese, and obese asthma and developed an obese asthma mouse model...
November 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29160122/reduced-soluble-toll-like-receptors-2-in-type-2-diabetes
#5
Emanuela Zaharieva, Tsvetelina Velikova, Adelina Tsakova, Zdravko Kamenov
BACKGROUND: Soluble forms of Toll-like receptors (sTLR) 2 and 4 exert negative regulatory control on membrane-bound receptor activation. The study estimates the sTLR2 and sTLR4's serum levels in type 2 diabetes (T2D) and evaluates their relationship with metabolic and inflammatory parameters. SUBJECTS AND METHODS: Sixty three patients with T2D and 25 controls were enrolled. sTLR were assayed through ELISA. Inflammatory markers included Interleukin 6 (IL-6), high sensitivity C-reactive protein (hs-CRP) and tumour necrosis factor α...
November 21, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29159716/rotula-aquatica-lour-attenuates-secretion-of-proinflammatory-mediators-and-cytokines-in-lipopolysaccharide-induced-inflammatory-responses-in-murine-raw-264-7-macrophages
#6
A Vysakh, Prasad Gopika, Kuriakose Jayesh, Raj Karishma, M S Latha
Rotula aquatica belongs to the family Boraginaceae, and is reported to contain baunerol, steroids and alkaloids. In Ayurveda, R. aquatica has been used for the treatment of various diseases such as diabetes, treatment of piles, venereal disease, and cancer. The current study aims to investigate the anti-inflammatory effect of methanolic extract of R. aquatica (MERA) in RAW 264.7 cells. The cytotoxicity of MERA was analyzed by MTT assay. The total cyclooxygenase (COX) activity, 5-lipoxygenase (5-LOX) activity, myeloperoxidase activity, inducible nitric oxide synthase activity, nitrate level and reactive oxygen species production were studied in LPS-stimulated RAW 264...
November 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29157803/iridoid-glycosides-fraction-from-picrorhiza-kurroa-attenuates-cyclophosphamide-induced-renal-toxicity-and-peripheral-neuropathy-via-ppar-%C3%AE-mediated-inhibition-of-inflammation-and-apoptosis
#7
Supriya Sharma, Pallavi Sharma, Pankaj Kulurkar, Damanpreet Singh, Dinesh Kumar, Vikram Patial
BACKGROUND: Picrorhiza kurroa Royle (Scrophulariaceae) is an important medicinal herb being widely used in variety of ailments. PURPOSE: The present study was envisaged to evaluate the effects of iridoid glycosides enriched fraction (IGs) from Picrorhiza kurroa rhizome against cyclophosphamide (CP) -induced renal toxicity and peripheral neuropathy. METHODS: Mice in different groups were pretreated with 25, 50 and 100 mg/kg; p.o. doses of IGs for 21 days, followed by cyclophosphamide intoxication for consecutive two days...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29154988/role-of-p-mkk7-in-myricetin-induced-protection-against-intestinal-ischemia-reperfusion-injury
#8
Yuchao Sun, Mengqiao Lian, Yuan Lin, Bin Xu, Yanli Li, Jin Wen, Dapeng Chen, Ming Xu, Marwan Almoiliqy, Li Wang
Intestinal ischemia reperfusion (I/R) may cause inflammation-, oxidative stress-, and apoptosis-related tissue injuries and facilitate bacterial infection, leading to multiple organ failure. Myricetin, a flavonoid, is found to have diverse biological effects including anti-inflammatory, anti-oxidative, and anti-bacterial effects. Based on our pre-experiment, we proposed that myricetin pretreatment (25, 50mg/kg) could ameliorate intestinal I/R injury and myricetin-induced modulation on MKK7/JNK signal pathway might play a key role in the amelioration...
November 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29154438/impact-of-heat-shock-protein-60kd-in-combination-with-outer-membrane-proteins-on-immune-response-against-brucella-melitensis
#9
Tooba Abbassi-Daloii, Soheil Yousefi, Mohammad Hadi Sekhavati, Mojtaba Tahmoorespur
Brucellosis caused by the bacterium Brucella affects various domestic and wild species. The outer membrane proteins 25 and 31 play key roles on stimulation of cell-mediated immune response against Brucella. GroEL as one of the major Brucella antigens stimulates the immune system and increases intracellular survival of bacteria. In the present study, we assumed injection of GroEL in combination with OMP25 and OMP31 would offer higher immunity levels. So, the impact of GroEL with different concentrations of recombinant outer membrane proteins emulsified in Chitosan Nanoparticles on immune responses was evaluated in mice model...
November 20, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29151411/-protective-effect-of-thalidomide-on-ali-induced-by-paraquat-poisoning-in-rats-and-its-mechanism
#10
Tao Liu, Yuan Xie, Mengtong Xu, Fenshuang Zheng
OBJECTIVE: To investigate the protective effect of thalidomide on acute lung injury (ALI) induced by paraquat (PQ) poisoning in rats and its possible mechanism. METHODS: Sixty SPF Wistar rats were randomly divided into six groups with 10 rats in each group. The rat model of PQ poisoning was reproduced by intraperitoneal injection of PQ solution 20 mg/kg (PQ model group), and the rats were treated by intraperitoneal injection of gradient thalidomide (50, 100, 200 mg/kg treatment groups) 30 minutes later continuously for 3 days...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29151409/-curative-effect-of-paraquat-detoxification-recipe-combined-with-continuous-hemoperfusion-in-the-treatment-of-patients-with-app-and-clinical-value-of-presepsin
#11
Weizhan Wang, Jing Li, Baoyue Zhu, Xun Gao, Qingmian Xiao, Hongna Qi, Yanqiao Ye, Yongjian Liu, Yongyan Han, Gongying Ma, Pu Wang
OBJECTIVE: To investigate the clinical effect of paraquat (PQ) detoxification recipe combined with continuous hemoperfusion (HP) in the treatment of patients with acute paraquat poisoning (APP) and clinical significance of soluble CD14 subtype (sCD14-st, Presepsin). METHODS: A prospective randomized controlled trial was conducted. 152 patients with moderate APP admitted to Department of Emergency Medicine of Harrison International Peace Hospital Affiliated to Hebei Medical University from July 2013 to June 2017 were enrolled, and they were randomly divided into three groups...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29150701/process-development-of-oxalic-acid-production-in-submerged-culture-of-aspergillus-niger-f22-and-its-biocontrol-efficacy-against-the-root-knot-nematode-meloidogyne-incognita
#12
Sang Il Lee, Keon Jin Lee, Ho Hyun Chun, Sanghyun Ha, Hyun Jung Gwak, Ho Myeong Kim, Jong-Hee Lee, Hak-Jong Choi, Hyeong Hwan Kim, Teak Soo Shin, Hae Woong Park, Jin-Cheol Kim
Oxalic acid has potent nematicidal activity against the root-knot nematode Meloidogyne incognita. In this study, fermentation parameters for oxalic acid production in submerged culture of Aspergillus niger F22 at 23, 25, and 30 °C were optimized in 5-L jar fermenters. The viscosity of the culture broth increased with increasing temperature. There was a negative correlation between oxalic acid production and the apparent viscosity; high volumetric productivity of oxalic acid was obtained at low apparent viscosity (less than 1000 cP), with a productivity of more than 100 mg/L h...
November 17, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29149904/concomitant-sequential-and-7-day-triple-therapy-in-first-line-treatment-of-helicobacter-pylori-infection-in-korea-study-protocol-for-a-randomized-controlled-trial
#13
Hyuk Lee, Beom Jin Kim, Sang Gyun Kim, Jin Il Kim, Il Ju Choi, Yong Chan Lee, Jae G Kim, Jae J Kim
BACKGROUND: Most international guidelines recommend triple-therapy regimens consisting of a proton pump inhibitor, clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of Helicobacter pylori. However, the efficacy of 7-day clarithromycin-based standard triple therapy for H. pylori infection is currently unacceptable in Korea. In this study, we will compare the efficacy and safety of 7-day standard triple therapy, 10-day sequential therapy, and 10-day concomitant therapy for the first-line treatment of H...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/29149783/hematological-improvement-of-patients-with-active-rheumatoid-arthritis-by-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-nsaid-with-immunosuppressive-property
#14
Hossein Ahmadi, Ahmad Reza Jamshidi, Mahdi Mahmoudi, Farhad Gharibdoost, Mahdi Vojdanian, Mohammad Javad Fattahi, Noushin Rastkari, Zahra Aghazadeh, Abbas Mirshafiey
The aim of this study was to investigate the effect of β-D-mannuronic acid (M2000) on hematological parameters in patients with active rheumatoid arthritis. This study was conducted on 25 patients with active rheumatoid arthritis (RA) (identifier: IRCT2014011213739N2). M2000 was administered orally for anemic and non-anemic RA patients at a dose of 500 mg twice daily for 12 weeks. The patients were permitted to continue the conventional treatments excluding NSAIDs. Blood samples were collected at baseline, 4 and 12 weeks after drug administration and were tested for hematological parameters...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29149171/risk-factors-for-hospitalizations-among-patients-with-cirrhosis-a-prospective-cohort-study
#15
Shari S Rogal, Viyan Udawatta, Imo Akpan, Akshata Moghe, Alexis Chidi, Amit Shetty, Eva Szigethy, Klaus Bielefeldt, Andrea DiMartini
This study was designed to assess unique baseline factors associated with subsequent hospitalizations in a cohort of outpatients with cirrhosis. A cohort of 193 patients with cirrhosis was recruited from an outpatient liver disease clinic at a single, tertiary medical center. Comorbidities, prescription medications, liver disease symptoms and severity, and psychiatric and pain symptoms were assessed at baseline using validated instruments. Inflammatory markers were measured using standardized Luminex assays...
2017: PloS One
https://www.readbyqxmd.com/read/29147882/growth-inhibition-patterns-and-transfer-factor-profiles-in-arsenic-stressed-rice-oryza-sativa-l
#16
Ha-Il Jung, Jinwook Lee, Mi-Jin Chae, Myung-Suk Kong, Chang-Hoon Lee, Seong-Soo Kang, Yoo-Hak Kim
Arsenic (As) accumulation in rice owing to uptake from the soil is a critical human health issue. Here, we studied the chemical properties of As-treated soils, growth inhibition patterns of As-stressed rice plants, changes in the As content of soil and soil solutions, and the relationship between As accumulation and As transfer factor from the soil to the rice organs. Rice plants were cultivated in a greenhouse under four concentrations of As: 0 (control), 25, 50, and 75 mg kg(-1). A significant positive correlation was found between available P2O5 and exchangeable K and between As concentration and available P2O5 or exchangeable K...
November 16, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29147443/4-nitroquinoline-1-oxide-induced-tongue-and-esophagus-carcinogenesis-in-obese-and-diabetic-tsod-mice
#17
Takuji Tanaka, Kunihiro Kawabata, Shigeyuki Sugie
Background: Obesity and diabetes mellitus are associated with lifestyle-related carcinogenesis. They are also risk factors of esophageal adenocarcinoma, but there are only a few reports on association between obesity/diabetes and development of squamous cell carcinoma in the oral cavity and esophagus. In this study, we therefore aimed to determine whether obesity and diabetes affect oral and esophageal carcinogenesis using model mice of obesity and diabetes, the Tsumura Suzuki obese diabetes (TSOD) and Tsumura Suzuki non-obesity (TSNO) control mice, which were treated with 4-nitroquinoline 1-oxide (4-NQO) to produce tongue and esophageal carcinomas...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29145330/pathologic-femoral-fracture-due-to-tenofovir-induced-fanconi-syndrome-in-patient-with-chronic-hepatitis-b-a-case-report
#18
You-Sung Suh, Dong-Il Chun, Sung-Woo Choi, Hwan-Woong Lee, Jae-Hwi Nho, Soon-Hyo Kwon, Jae-Ho Cho, Sung Hun Won
RATIONALE: We report a case of a hepatitis B virus (HBV)-positive patient with preexisting bone disease who developed tenofovir-induced Fanconi syndrome and subsequently sustained pathologic fracture. To our best knowledge, this is the first report in the English literature about pathologic femoral fracture due to tenofovir-induced Fanconi syndrome in patient with chronic hepatitis B (CHB). The present report describes detailed our experience with the diagnosis of pathologic femoral fracture due to tenofovir-induced Fanconi syndrome and treatment...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142605/aviscumine-a-recombinant-ribosomal-inhibitor-increases-the-antitumor-activity-of-natural-killer-cells
#19
Gabriele Gamerith, Arno Amann, Bettina Schenk, Thomas Auer, Hans Lentzen, Dirk O Mügge, Katharina M Cima, Judith Löffler-Ragg, Wolfgang Hilbe, Heinz Zwierzina
Aviscumine, a recombinant lectin I, has been identified as an immunomodulatory agent within a new class of ribotoxic stress-inducing anticancer substances that have demonstrated efficacy in phase I/II trials. The aim of the present study was to elucidate the presumed effect of aviscumine on enhancing human natural killer (NK) cell antitumor cytotoxicity. To measure the effect of aviscumine on human NK cell cytotoxicity, chromium-51-release assays against K-562 cells were performed with isolated NK cells from the whole blood of 34 healthy volunteers...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29142418/marantodes-pumilum-blume-kuntze-inhibited-secretion-of-lipopolysaccharide-and-monosodium-urate-crystal-stimulated-cytokines-and-plasma-prostaglandin-e2
#20
Eldiza Puji Rahmi, Jamia Azdina Jamal, Endang Kumolosasi, Juriyati Jalil, Nor-Ashila Aladdin
Background: Marantodes pumilum is traditionally used for dysentery, gonorrhea, and sickness in the bones. Previous studies revealed its antibacterial and xanthine oxidase inhibitory activities. Objective: To evaluate the inhibitory effects of three M. pumilum varieties on the secretion of lipopolysaccharide (LPS)- and monosodium urate crystal (MSU)-induced cytokines and plasma prostaglandin E2 (PGE2) in vitro. Materials and Methods: The leaves and roots of M...
October 2017: Pharmacognosy Magazine
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