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https://www.readbyqxmd.com/read/29786742/a-novel-alendronate-functionalized-nanoprobe-for-simple-colorimetric-detection-of-cancer-associated-hypercalcemia
#1
Abhishek Sahu, Youngmin Hwang, Cristian Vilos, Jong-Min Lim, Sunghyun Kim, Won Il Choi, Giyoong Tae
The calcium (Ca2+) ion concentration in the blood serum is tightly regulated, and any abnormalities in the level of serum calcium ions are associated with many potentially dangerous diseases. Thus, monitoring of the Ca2+ ion concentration in the blood serum is of fundamental importance. Gold nanoparticle (GNP)-based colorimetric biosensors have enormous potential in clinical diagnostic applications due to their simplicity, versatility, and unique optical properties. In this study, we have developed an alendronate functionalized gold nanoparticle (GNP-ALD) system for the measurement of Ca2+ ion concentration in biological samples...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29785459/intracorporeal-delta-shaped-gastroduodenostomy-in-reduced-port-robotic-distal-subtotal-gastrectomy-technical-aspects-and-short-term-outcomes
#2
Joong Ho Lee, Taeil Son, Jisu Kim, Won Jun Seo, Chul Kyu Rho, Minah Cho, Hyoung-Il Kim, Woo Jin Hyung
BACKGROUND: Gastroduodenostomy is preferred as a method of reconstruction following distal subtotal gastrectomy. However, in initial reports on reduced-port gastrectomy, gastroduodenostomy has rarely been performed therein because of technical difficulties. The present study describes a novel intracorporeal gastroduodenostomy technique applicable during reduced-port robotic distal subtotal gastrectomy. METHODS: Data were retrospectively reviewed for cases of reduced-port (three-port) robotic distal subtotal gastrectomy with intracorporeal delta-shaped gastroduodenostomy performed from February 2016 to December 2016...
May 21, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29784924/allergy-immunotherapy-restores-airway-epithelial-barrier-dysfunction-through-suppressing-il-25-induced-endoplasmic-reticulum-stress-in-asthma
#3
Xiefang Yuan, Junyi Wang, Yin Li, Xiang He, Bin Niu, Dehong Wu, Nan Lan, Xiaoyun Wang, Yun Zhang, Xi Dai, Xing Wang, Zhigang Liu, Guoping Li
Constant exposure to allergen triggers destructive type 2 cell-mediated inflammation. The effect of allergen specific immunotherapy (SIT) in maintaining airway epithelial barrier function in asthma remains unknown. In the current study, we showed that SIT maintained airway epithelial homeostasis in mice exposed to dermatophagoides farinae (Der f), which induced increased expression of IL-25, endoplasmic reticulum (ER) stress and airway epithelial apoptosis. Meanwhile, SIT treatment ameliorated airway inflammatory infiltration and hyper-responsiveness in allergic mice...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29783820/-efficacy-of-bronchoalveolar-lavage-and-its-influence-factors-in-the-treatment-of-mycoplasma-pneumoniae-pneumonia-with-atelectasis
#4
M Yang, D H Yang, X Yang, Y S Wang, L Wu, Z M Chen
Objective: To investigate the efficacy of bronchoalveolar lavage (BAL) and its influence factors in the treatment of Mycoplasma pneumoniae pneumonia (MPP) with atelectasis. Methods: A retrospective case control study was performed on hospitalized MPP patients with atelectasis and received BAL in the Department of Pulmonology, Children's Hospital Zhejiang University School of Medicine from January 1, 2015 to July 31, 2017. Fever relieved in 48 hours and chest imaging improved in one week after BAL were considered effective...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29783063/inflammatory-patterns-in-takotsubo-cardiomyopathy-and-acute-coronary-syndrome-a-propensity-score-matched-analysis
#5
Francesco Santoro, Maria Domenica Costantino, Francesca Guastafierro, Giuseppe Triggiani, Armando Ferraretti, Nicola Tarantino, Ardan Saguner, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND AND AIMS: Systemic inflammatory activation can be observed in both Takotsubo cardiomyopathy (TTC) and acute coronary syndrome (ACS). The aim of this study was therefore to compare circulating cytokine levels during the acute and subacute phase of TTC and ACS. METHODS: One hundred thirty-six consecutive patients were enrolled in the study; after a propensity score matching, 32 TTC patients were compared with 32 subjects with ACS. Clinical baseline features and circulating levels of interleukin(IL)-1β, IL-1α, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ, MCP1, EGF, VEGF, TNFα were obtained at admission (t0 ) and after 120 h (t1 )...
May 18, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29779777/interleukin-23-interleukin-17-axis-activated-by-mycobacterium-avium-complex-mac-is-attenuated-in-patients-with-mac-lung-disease
#6
Chin-Chung Shu, Jann-Yuan Wang, Ming-Fang Wu, Hsin-Chih Lai, Bor-Luen Chiang, Chong-Jen Yu
BACKGROUND: Mycobacterium avium complex (MAC)-lung disease (LD) is increasing in patients without human immunodeficiency virus infection. However, data on host vulnerability to MAC-related immune responses, and in particular the interleukin (IL)-23/IL-17 axis, are lacking. METHODS: We enrolled 50 patients with MAC-LD, 25 age-matched patients with tuberculosis (TB) and 25 controls. We measured levels of plasma cytokines, and studied IL-12/IL-17 responses in macrophage and lymphocyte activation to MAC...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779365/hierarchical-metal-organic-framework-assembled-membrane-filter-for-efficient-removal-of-particulate-matter
#7
Won-Tae Koo, Ji-Soo Jang, Shaopeng Qiao, Wontae Hwang, Gaurav Jha, Reginald M Penner, Il-Doo Kim
Here, we propose heterogeneous nucleation assisted hierarchical growth of metal-organic framework (MOF) for efficient particulate matter (PM) removal. The assembly of 2-dimensional (2D) Zn based zeolite imidazole framework (2D-ZIF-L) in deionized water over a period time produced hierarchical ZIF-L (H-ZIF-L) on hydrophilic substrates. During the assembly, the 2nd nucleation and growth of ZIF-L occurred on the surface of 1st ZIF-L, leading to the formation of flower-like H-ZIF-L on the substrate. The flower-like H-ZIF-L was easily synthesized on various substrates, including glass, polyurethane 3D foam, nylon microfibers, and non-woven fabrics...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29778504/solitary-chemosensory-cells-are-a-primary-epithelial-source-of-interleukin-25-in-chronic-rhinosinusitis-with-nasal-polyps
#8
Michael A Kohanski, Alan D Workman, Neil N Patel, Li-Yin Hung, Julie P Shtraks, Bei Chen, Mariel Blasetti, Laurel Doghramji, David W Kennedy, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen
BACKGROUND: IL-25 can function as an early signal for the respiratory Type 2 response characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In the mouse gut, tuft cells are the epithelial source of IL-25. However, the source of human airway epithelial IL-25 has remained elusive. OBJECTIVE: In this study, we sought to determine if the solitary chemosensory cell (SCC) is the predominant source of IL-25 in the sinonasal epithelium...
May 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29777383/predictive-value-of-pct-and-il-6-for-bacterial-infection-in-children-with-cancer-and-febrile-neutropenia
#9
Hilde T van der Galiën, Erik A H Loeffen, Karin G E Miedema, Wim J E Tissing
PURPOSE: Only a third of children with cancer and febrile neutropenia (FN) have a proven bacterial infection; nevertheless, most children are hospitalized and treated with intravenous antibiotics. Several biomarkers have been proposed as predictive markers for bacterial infection in this population. We aimed to evaluate the role of interleukin-6 (IL-6) and procalcitonin (PCT) in diagnosing bacterial infection in children with cancer and FN. METHODS: The study population was derived from a prospective database (2006-2013, IL-8 study) comprising children with cancer who presented with FN...
May 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29777144/benefits-in-radical-mastectomy-protocol-a-randomized-trial-evaluating-the-use-of-regional-anesthesia
#10
Marcio Matsumoto, Eva M Flores, Pedro P Kimachi, Flavia V Gouveia, Mayra A Kuroki, Alfredo C S D Barros, Marcelo M C Sampaio, Felipe E M Andrade, João Valverde, Eduardo F Abrantes, Claudia M Simões, Rosana L Pagano, Raquel C R Martinez
Surgery is the first-line treatment for early, localized, or operable breast cancer. Regional anesthesia during mastectomy may offer the prevention of postoperative pain. One potential protocol is the combination of serratus anterior plane block (SAM block) with pectoral nerve block I (PECS I), but the results and potential benefits are limited. Our study compared general anesthesia with or without SAM block + PECS I during radical mastectomy with axillary node dissection and breast reconstruction using evaluations of pain, opioid consumption, side effects and serum levels of interleukin (IL)-1beta, IL-6 and IL-10...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776658/ustekinumab-for-refractory-giant-cell-arteritis-a-prospective-52-week-trial
#11
Richard Conway, Lorraine O'Neill, Phil Gallagher, Geraldine M McCarthy, Conor C Murphy, Douglas J Veale, Ursula Fearon, Eamonn S Molloy
OBJECTIVES: Giant cell arteritis (GCA) is the most common form of systemic vasculitis. Glucocorticoids are an effective treatment but have significant adverse events and relapses are common. Interleukins 12 (IL-12) and 23 (IL-23) stimulate TH 1 and TH 17 responses and are implicated in the pathogenesis of GCA. The aim of this study was to evaluate the efficacy and safety of IL-12/23 blockade with ustekinumab in GCA. METHODS: We performed a prospective open label study of ustekinumab in patients with refractory GCA...
April 22, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29776428/evidence-of-the-impact-of-systemic-inflammation-on-neuroinflammation-from-a-non-bacterial-endotoxin-animal-model
#12
Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong, Raymond Chuen Chung Chang
BACKGROUND: Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory. This study uses a single model, laparotomy without any pathogen, to characterize these changes and their responses to anti-inflammatory treatment in the intermediate term. METHODS: In a two-part experiment, wild-type C57BL/6N mice (male, 3 month old, 25 ± 2 g) were subjected to sevoflurane anesthesia alone or to a laparotomy...
May 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29773890/intraperitoneal-administration-of-the-anti-il-23-antibody-prevents-the-establishment-of-intestinal-nematodes-in-mice
#13
M Gomez-Samblas, D Bernal, A Bolado-Ortiz, S Vilchez, F Bolás-Fernández, A M Espino, M Trelis, A Osuna
Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p < 0...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773169/comparison-of-the-effect-of-dietary-copper-nanoparticles-and-one-copper-ii-salt-on-the-metabolic-and-immune-status-in-a-rat-model
#14
Ewelina Cholewińska, Jerzy Juśkiewicz, Katarzyna Ognik
The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two different chemical forms (carbonate and nanoparticles) on metabolic, immune and antioxidant status in a rat model. Five experimental treatments (8 rats in each) were used to test different dosages of Cu added to the diet (standard -6.5 mg/kg, half the standard dosage -3.25 mg/kg, and no added Cu as a negative control) and two sources of added copper (standard -CuCO3 and copper nanoparticles -CuNPs). Blood and urine samples were collected from all the animals after four weeks of treatment...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773130/identification-of-emu-tegp11-an-ef-hand-domain-containing-tegumental-protein-of-echinococcus-multilocularis
#15
Yadong Zheng, Xiaola Guo, Meng Su, Xiaoqian Chen, Xiaoliang Jin, Juntao Ding, Zhengrong Wang, Xinwen Bo, Mazhar Ayaz, Ivan Kutyrev, Wanzhong Jia, Xichen Zhang, Jing Zhang
Tegumental proteins (TegPs) are a group of proteins that coat on the surface of worms, mainly being involved in ion uptake and immune evasion. Echinococcus species have many TegPs, but none of them have been characterized and their role remains unclear. The genome-wide analysis revealed that there were at least 14 tegp genes (tegp1 - 14) in Echinococcus species, the majority of which were found to contain an EF-hand domain or a dynein light chain-like domain or both. Despite low identity, all TegP11 proteins from 25 flatworms were conserved in structure...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772806/cancer-incidence-trend-in-the-hebei-spirit-oil-spill-area-from-1999-to-2014-an-ecological-study
#16
Kyung-Hwa Choi, Myung-Sook Park, Mina Ha, Jong-Il Hur, Hae-Kwan Cheong
The Hebei Spirit oil spill (HSOS) occurred in the Republic of Korea on 7 December 2007. We aimed to describe the cancer incidence trend in Taean County before and after the oil spill. Five major cancers and leukemia were analyzed. Cancer incidence data were obtained from the Korean National Cancer Center. We compared the standardized incidence rates in Taean with those observed nationwide and selected three coastal areas. Joinpoint regression analysis was used to examine the trends in the average annual percent change and perform comparisons...
May 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29772098/insights-in-particulate-matter-induced-allergic-airway-inflammation-focus-on-the-epithelium
#17
Katrien C De Grove, Sharen Provoost, Guy G Brusselle, Guy F Joos, Tania Maes
Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM-induced respiratory responses...
May 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29771438/methylene-blue-attenuates-renal-ischemia-reperfusion-injury-by-negative-regulation-of-nlrp3-signaling-pathway
#18
J-J Liu, L Lu, F-Q Hu, H Yuan, Q Xu, Y-F Qin, J-H Gong
OBJECTIVE: To investigate the effect of methylene blue (MB) on renal ischemia-reperfusion (IR) injury in mice and its possible relevant mechanisms. MATERIALS AND METHODS: A total of 30 male C57/BL6 mice aged 4 months old were randomly divided into the following three groups: Sham group (n=10), IR group (n=10), and MB group (n=10). Mice in MB group were treated with gavage continuously using methylene blue solution (dosage: 25 mg·kg-1·d-1) until they were 7 months old...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29765986/advanced-glycation-end-products-enhance-murine-monocyte-proliferation-in-bone-marrow-and-prime-them-into-an-inflammatory-phenotype-through-mapk-signaling
#19
Xian Jin, Liang Liu, Yaping Zhang, Yin Xiang, Guizhi Yin, Yi Lu, Ludong Shi, Jian Dong, Chengxing Shen
Objective: Increased monocytes, particularly the inflammatory subset, are associated with accelerated atherosclerosis in diabetes through thus far incompletely defined mechanisms. The present study tested the hypothesis that advanced glycation end products (AGEs) promote bone marrow monocytes to proliferate and drive them into an inflammatory phenotype. Methods and Results: In vivo, AGEs (25 mg/kg i.p. for 7 days) increased proportions of CD115+ monocytes and the inflammatory subset, the CD115+ Ly6Chigh cells, in murine bone marrow (flow cytometry analysis (FCM)), and enhanced gene expression of proinflammatory cytokines (IL-1 β and TNF- α ) but only slightly upregulated mRNA expression of anti-inflammatory cytokine (IL-10) (real-time PCR) in monocytes...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29764548/-effects-of-different-core-temperatures-after-heat-strike-on-serum-inflammatory-cytokines-and-multiple-organ-dysfunction-syndrome-in-rats
#20
Qinghua Li, Rongqing Sun, Hongdi Lyu, Dexin Shen, Qing Hu, Haiwei Wang, Nannan Wang, Jin Yan, Jing Wang
OBJECTIVE: To observe the effect of different core temperatures (Tc) after heat strike on serum inflammatory cytokines and multiple organ dysfunction syndrome (MODS) in rat. METHODS: 120 male Sprague-Dawley (SD) rats were randomly divided into normal control group (n = 30) and heat strike group (n = 90). The rats in heat strike group were put into simulated thermal climate animal module after adaptive training. The module temperature was raised to 39 centigrade in 30 minutes with 65% humidity...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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