Xiaogang Feng, Tilde Andersson, Julia Gschwend, Pascal Flüchter, Ivan Berest, Julian L Muff, Daniele Carchidi, Antonie Lechner, Jeshua C de Tenorio, Nina Brander, Ulrich Boehm, Christoph S N Klose, David Artis, Trese Leinders-Zufall, Frank Zufall, Christoph Schneider
The tuft cell-ILC2 circuit orchestrates rapid type 2 responses upon detecting microbe-derived succinate and luminal helminths. Our findings delineate key mechanistic steps, involving IP3R2 engagement and Ca 2+ flux, governing IL-25 production by tuft cells triggered by succinate detection. While IL-17RB plays a pivotal intrinsic role in ILC2 activation, it exerts a regulatory function in tuft cells. Tuft cells exhibit constitutive Il25 expression, placing them in an anticipatory state that facilitates rapid production of IL-25 protein for ILC2 activation...
March 8, 2024: bioRxiv