keyword
https://read.qxmd.com/read/38496438/tuft-cell-il-17rb-restrains-il-25-bioavailability-and-reveals-context-dependent-ilc2-hypoproliferation
#1
Xiaogang Feng, Tilde Andersson, Julia Gschwend, Pascal Flüchter, Ivan Berest, Julian L Muff, Daniele Carchidi, Antonie Lechner, Jeshua C de Tenorio, Nina Brander, Ulrich Boehm, Christoph S N Klose, David Artis, Trese Leinders-Zufall, Frank Zufall, Christoph Schneider
The tuft cell-ILC2 circuit orchestrates rapid type 2 responses upon detecting microbe-derived succinate and luminal helminths. Our findings delineate key mechanistic steps, involving IP3R2 engagement and Ca 2+ flux, governing IL-25 production by tuft cells triggered by succinate detection. While IL-17RB plays a pivotal intrinsic role in ILC2 activation, it exerts a regulatory function in tuft cells. Tuft cells exhibit constitutive Il25 expression, placing them in an anticipatory state that facilitates rapid production of IL-25 protein for ILC2 activation...
March 8, 2024: bioRxiv
https://read.qxmd.com/read/37970362/il25-macrophages-are-a-key-determinant-of-treatment-resistance-of-il17rb-breast-cancer
#2
JOURNAL ARTICLE
Yukinori Ozaki, Keiichi Kinowaki, Hidetaka Kawabata, Chie Kudo-Saito
Recurrence and metastasis are resistant to multimodal treatments, and are the major causes of death in breast cancer. Accumulating evidence suggests that the IL17RB signaling pathway plays a key role in progression and metastasis of breast cancer. Clinical significance of the IL17RB positivity in tumor tissues has been also reported as a poor prognostic factor in breast cancer. However, the molecular mechanisms underlying the poor prognosis of patients with IL17RB+ breast cancer, particularly the immunological aspects, remain to be fully elucidated, and elimination of the IL17RB+ tumors has not been practically achieved in clinical settings...
2023: American Journal of Cancer Research
https://read.qxmd.com/read/37907122/th2-cell-clonal-expansion-at-diagnosis-in-human-type-1-diabetes
#3
JOURNAL ARTICLE
Aditi Narsale, Francisco Almanza, Theo Tran, Breanna Lam, David Seo, Alisa Vu, S Alice Long, Laura Cooney, Elisavet Serti, Joanna D Davies
Soon after diagnosis with type 1 diabetes (T1D), many patients experience a period of partial remission. A longer partial remission is associated with a better response to treatment, but the mechanism is not known. The frequency of CD4+ CD25+ CD127hi (127-hi) cells, a cell subset with an anti-inflammatory Th2 bias, correlates positively with length of partial remission. The purpose of this study was to further characterize the nature of the Th2 bias in 127-hi cells. Single cell RNA sequencing paired with TCR sequencing of sorted 127-hi memory cells identifies clonally expanded Th2 clusters in 127-hi cells from T1D, but not from healthy donors...
October 29, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37448179/il17rb-expression-is-associated-with-malignant-cancer-behaviors-and-poor-prognosis-in-oral-cancer
#4
JOURNAL ARTICLE
Shyng-Shiou F Yuan, Chang-Wei Su, Leong-Perng Chan, Hieu D H Nguyen, Yuk-Kwan Chen, Je-Kang Du, Kuang-Hung Cheng, Yen-Yun Wang
OBJECTIVES: Previously, we demonstrated that IL17RB plays an essential role in lung cancer progression. This study aimed to determine whether IL17RB correlates with oral cancer and promotes oral cancer progression. SUBJECTS AND METHODS: IL17RB expression in oral cancer tissues and normal tissues was determined by immunohistochemistry staining, while the association of IL17RB expression with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC) patients was analyzed and its correlation with progression-free survival and response to radiotherapy and chemotherapy in OSCC patients was also explored...
July 13, 2023: Oral Diseases
https://read.qxmd.com/read/37194082/cinc-2-and-mir-199a-5p-in-evs-secreted-by-transplanted-thy1-cells-activate-hepatocytic-progenitor-cell-growth-in-rat-liver-regeneration
#5
JOURNAL ARTICLE
Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi, Toshihiro Mitaka
BACKGROUND: Small hepatocyte-like progenitor cells (SHPCs) are hepatocytic progenitor cells that transiently form clusters in rat livers treated with retrorsine (Ret) that underwent 70% partial hepatectomy (PH). We previously reported that transplantation of Thy1+ cells obtained from D-galactosamine-treated livers promotes SHPC expansion, thereby accelerating liver regeneration. Extracellular vesicles (EVs) secreted by Thy1+ cells induce sinusoidal endothelial cells (SECs) and Kupffer cells (KCs) to secrete IL17B and IL25, respectively, thereby activating SHPCs through IL17 receptor B (RB) signaling...
May 16, 2023: Stem Cell Research & Therapy
https://read.qxmd.com/read/37111458/-il17rb-and-il17rel-expression-are-associated-with-improved-prognosis-in-hpv-infected-head-and-neck-squamous-cell-carcinomas
#6
JOURNAL ARTICLE
Yuhan Sun, Md Abdullah Al Kamran Khan, Stefano Mangiola, Alexander David Barrow
Changes in the cellular secretome are implicated in virus infection, malignancy, and anti-tumor immunity. We analyzed the association between transcriptional signatures (TS) from 24 different immune and stromal cell types on the prognosis of HPV-infected and HPV-free head and neck squamous carcinoma (HNSCC) patients from The Cancer Genome Atlas (TCGA) cohort. We found that HPV-positive HNSCC patients have tumors with elevated immune cell TS and improved prognosis, which was specifically associated with an increased tumor abundance of memory B and activated natural killer (NK) cell TS, compared to HPV-free HNSCC patients...
April 7, 2023: Pathogens
https://read.qxmd.com/read/37083768/faim2-is-correlated-with-metastasis-of-medulloblastoma-through-bioinformatics-analysis
#7
JOURNAL ARTICLE
Xiaojun Zhou, Hao Zhao
Medulloblastoma (MB) is one of the most frequent malignant brain tumors in children. The metastasis of MB outside the nervous system is associated with a poor prognosis. Our study aimed to explore the genes correlated with metastasis in MB. Using the data downloaded from the gene expression omnibus database, the differentially expressed genes were identified between the metastatic and nonmetastatic samples in MB, which were undergone functional enrichment. Prognosis related genes were identified using univariate Cox regression analysis...
April 21, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/36267311/construction-of-a-colorectal-cancer-prognostic-risk-model-and-screening-of-prognostic-risk-genes-using-machine-learning-algorithms
#8
JOURNAL ARTICLE
Xuezhi Du, Han Qi, Wenbin Ji, Peiyuan Li, Run Hua, Wenliang Hu, Feng Qi
This study is aimed at constructing a prognostic risk model for colorectal cancer (CRC) using machine-learning algorithms to provide accurate staging and screening of credible prognostic risk genes. We extracted CRC data from GSE126092 and GSE156355 of the Gene Expression Omnibus (GEO) database and datasets from TCGA to analyze the differentially expressed genes (DEGs) using bioinformatics analysis. Among the 330 shared DEGs related to CRC prognosis, we divided the analysis period into different phases and applied univariate COX regression, LASSO, and multivariate COX regression analysis...
2022: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/36250525/chronic-allergic-asthma-alters-m6a-epitranscriptomic-tagging-of-mrnas-and-lncrnasin-the-lung
#9
JOURNAL ARTICLE
Xiuqin Ni, Xing Li, Bing Hu, Li Wang
To evaluate the role of m6A methylation of mRNAs and long non-coding RNAs (lncRNAs) in chronic allergic asthma. Transcriptome-wide m6A changes in BALB/c mice were profiled using immunoprecipitated methylated RNAs with microarrays in lung with chronic allergic asthma. Gene ontology and KEGG analysis were conducted. Target genes were verified by methylated RNA immunoprecipitation and real-time polymerase chain reaction (PCR). Specifically, the mRNA levels of m6A writers (METTL3, METTL14, and WTAP), and readers and erasers (FTO and ALKBH5) were estimated by real-time PCR analysis, using the SYBR-green method...
October 17, 2022: Bioscience Reports
https://read.qxmd.com/read/35885510/gene-expression-profile-of-stromal-factors-in-cancer-associated-fibroblasts-from-prostate-cancer
#10
JOURNAL ARTICLE
Noemi Eiro, Jesús María Fernández-Gómez, Cristina Gonzalez-Ruiz de León, Maria Fraile, Jorge Gonzalez-Suarez, Beatriz Lobo-Rodríguez, Jorge García-Rodríguez, Safwan Escaf, Francisco J Vizoso
Recent investigations point at the stromal microenvironment to assess additional diagnostic information and provide new therapeutic targets in cancer. The aim of the study was to contribute to the characterization of the phenotype of cancer-associated fibroblasts (CAFs) in prostate cancer (PCa) compared with normal prostate-associated fibroblasts (NAFs) and fibroblasts from benign prostatic hyperplasia (BPH). Three patient populations were prospectively recruited: 23 patients with new localized PCa, 14 patients with advanced PCa treated with androgenic deprivation therapy (ADT), and 7 patients with BPH...
June 30, 2022: Diagnostics
https://read.qxmd.com/read/35844575/antigenic-determinants-of-sars-cov-2-specific-cd4-t-cell-lines-reveals-m-protein-driven-dysregulation-of-interferon-signaling
#11
JOURNAL ARTICLE
Pedro H Gazzinelli-Guimaraes, Gayatri Sanku, Alessandro Sette, Daniela Weiskopf, Paul Schaughency, Justin Lack, Thomas B Nutman
We generated CD4+ T cell lines (TCLs) reactive to either SARS-CoV-2 spike (S) or membrane (M) proteins from unexposed naïve T cells from six healthy donor volunteers to understand in fine detail whether the S and M structural proteins have intrinsic differences in driving antigen-specific CD4+ T cell responses. Having shown that each of the TCLs were antigen-specific and antigen-reactive, single cell mRNA analyses demonstrated that SARS-CoV-2 S and M proteins drive strikingly distinct molecular signatures...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35810502/enhancing-early-life-nutrition-alters-the-hepatic-transcriptome-of-angus-%C3%A3-holstein-friesian-heifer-calves
#12
JOURNAL ARTICLE
C J Byrne, A K Kelly, K Keogh, D A Kenny
Early life nutrition has a major influence on subsequent lifetime performance in cattle. The aim of this experiment was to investigate the effect of plane of nutrition from 3 to 21 weeks of age on the liver transcriptome. Holstein-Friesian × Angus heifer calves with a mean (±SD) age and BW of 19 (±5) days and 51.2 (±7.8) kg, respectively, were assigned to either a high-energy diet to support a mean average daily gain (ADG) of 1.2 kg/day (HI; n = 15) or a moderate diet (MOD; n = 15) to support a mean ADG of 0...
July 7, 2022: Animal
https://read.qxmd.com/read/35755802/liver-kinase-b1-regulates-remodeling-of-the-tumor-microenvironment-in-triple-negative-breast-cancer
#13
JOURNAL ARTICLE
Connor T King, Margarite D Matossian, Jonathan J Savoie, Khoa Nguyen, Maryl K Wright, C Ethan Byrne, Steven Elliott, Hope E Burks, Melyssa R Bratton, Nicholas C Pashos, Bruce A Bunnell, Matthew E Burow, Bridgette M Collins-Burow, Elizabeth C Martin
Liver kinase B1 (LKB1) is a potent tumor suppressor that regulates cellular energy balance and metabolism as an upstream kinase of the AMP-activated protein kinase (AMPK) pathway. LKB1 regulates cancer cell invasion and metastasis in multiple cancer types, including breast cancer. In this study, we evaluated LKB1's role as a regulator of the tumor microenvironment (TME). This was achieved by seeding the MDA-MB-231-LKB1 overexpressing cell line onto adipose and tumor scaffolds, followed by the evaluation of tumor matrix-induced tumorigenesis and metastasis...
2022: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/35506298/microrna-155-5p-modulates-the-progression-of-acute-respiratory-distress-syndrome-by-targeting-interleukin-receptors
#14
JOURNAL ARTICLE
Zhenfei Huang, Hui Huang, Meirong Shen, Changrong Li, Chao Liu, Huayong Zhu, Weiwei Zhang
Acute respiratory distress syndrome (ARDS) is a multifactorial inflammatory lung failure with a high incidence and a high cost burden. However, the underlying pathogenesis of ARDS is still unclear. Recently, microRNA has been shown to have critical function in regulating the pathogenesis of ARDS development and inflammation. To identify the important microRNA in the serum from patients with ARDS that may be potential biomarkers for the disease and explore the underlying disease mechanism. We found significant upregulation of miR-155-5p expression in serum samples from patients with ARDS compared with the control group (p < 0...
May 2022: Bioengineered
https://read.qxmd.com/read/34724890/development-of-a-prognostic-signature-of-patients-with-esophagus-adenocarcinoma-by-using-immune-related-genes
#15
JOURNAL ARTICLE
Xiangxin Zhang, Liu Yang, Ming Kong, Jian Ma, Yutao Wei
BACKGROUND: Esophageal adenocarcinoma (EAC) is an aggressive malignancy with a poor prognosis. The immune-related genes (IRGs) are crucial to immunocytes tumor infiltration. This study aimed to construct a IRG-related prediction signature in EAC. METHODS: The related data of EAC patients and IRGs were obtained from the TCGA and ImmPort database, respectively. The cox regression analysis constructed the prediction signature and explored the transcription factors regulatory network through the Cistrome database...
November 1, 2021: BMC Bioinformatics
https://read.qxmd.com/read/34716287/construction-and-verification-of-a-hypoxia-stemness-based-gene-signature-for-risk-stratification-in-esophageal-cancer
#16
JOURNAL ARTICLE
Kang Tang, Yong Cheng, Qian Li
BACKGROUND Numerous studies have shown that esophageal cancer (ESCA) contains areas of intertumoral hypoxia. It is widely accepted that the association of hypoxia with cancer stemness in the tumor microenvironment of ESCA is of profound clinical significance. However, reliable prognostic signatures based on hypoxia and cancer stemness are still lacking in ESCA. MATERIAL AND METHODS The t-SNE algorithm was used to estimate the hypoxia status based on the transcriptome profiles of the discovery cohort in the TCGA database...
October 30, 2021: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/34449811/critical-role-of-il-25-ilc2-il-5-axis-in-the-production-of-anti-francisella-lps-igm-by-b1-b-cells
#17
JOURNAL ARTICLE
Carlos Henrique D Barbosa, Louis Lantier, Joseph Reynolds, Jinyong Wang, Fabio Re
B1 cells, a subset of B lymphocytes whose developmental origin, phenotype, and function differ from that of conventional B2 cells, are the main source of "natural" IgM but can also respond to infection by rapidly producing pathogen-specific IgM directed against T-independent antigens. Francisella tularensis (Ft) is a Gram-negative bacterium that causes tularemia. Infection with Ft Live Vaccine Strain activates B1 cells for production of IgM directed against the bacterial LPS in a process incompletely understood...
August 27, 2021: PLoS Pathogens
https://read.qxmd.com/read/34381138/effect-of-black-ginseng-and-silkworm-supplementation-on-obesity-the-transcriptome-and-the-gut-microbiome-of-diet-induced-overweight-dogs
#18
JOURNAL ARTICLE
Miey Park, Ki Hyun Kim, Varun Jaiswal, Jihee Choi, Ju Lan Chun, Kang Min Seo, Mi-Jin Lee, Hae-Jeung Lee
Like humans, weight control in overweight dogs is associated with a longer life expectancy and a healthier life. Dietary supplements are one of the best strategies for controlling obesity and obesity-associated diseases. This study was conducted to assess the potential of black ginseng (BG) and silkworm (SW) as supplements for weight control in diet-induced overweight beagle dogs. To investigate the changes that occur in dogs administered the supplements, different obesity-related parameters, such as body condition score (BCS), blood fatty acid profile, transcriptome, and microbiome, were assessed in high energy diet (HD) and HD with BG + SW supplementation (HDT) groups of test animals...
August 11, 2021: Scientific Reports
https://read.qxmd.com/read/34304115/the-significance-of-hoxb7-and-il17rb-serum-levels-in-prognosis-of-hormonally-dependent-breast-cancer-a-pilot-study
#19
JOURNAL ARTICLE
Nataša Todorović-Raković, Jelena Milovanović, John Greenman, Marko Radulovic
PURPOSE: Improved prognostication of a patient's outcome could allow for personalized treatment decisions in breast cancer. Homeobox B7 (HOXB7) and interleukin 17 receptor B (IL17RB) are proteins reportedly involved in the development of hormonal therapy resistance. Their prognostic value was previously investigated in tumor tissue but recent mass spectrometric detection of HOXB7 and IL17RB proteins in serum has prompted us to perform the first prognostic evaluation of their serum levels...
July 22, 2021: Advances in Medical Sciences
https://read.qxmd.com/read/33545363/identification-of-novel-serological-autoantibodies-in-takayasu-arteritis-patients-using-huprot-arrays
#20
JOURNAL ARTICLE
Xiaoting Wen, Guang Song, Chaojun Hu, Jianbo Pan, Ziyan Wu, Liubing Li, Chenxi Liu, Xinping Tian, Fengchun Zhang, Jiang Qian, Heng Zhu, Yongzhe Li
To identify novel autoantibodies of Takayasu arteritis (TAK) using HuProt array-based approach. A two-phase approach was adopted. In Phase I, serum samples collected from 40 TAK patients, 15 autoimmune disease patients, and 20 healthy subjects were screened to identify TAK-specific autoantibodies using human protein (HuProt) arrays. In Phase II, the identified candidate autoantibodies were validated with TAK-focused arrays using an additional cohort comprised of 109 TAK patients, 110 autoimmune disease patients, and 96 healthy subjects...
February 2, 2021: Molecular & Cellular Proteomics: MCP
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