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IL17RB

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https://www.readbyqxmd.com/read/28421819/il-4-induces-the-il17rb-gene-transcription-in-monocytic-cells-with-coordinate-autocrine-il-25-signaling
#1
Nathaniel M Weathington, Shreya S Kanth, Qiaoke Gong, James Londino, Akihiko Hoji, Mauricio Rojas, John Trudeau, Sally Wenzel, Rama K Mallampalli
IL-25 and IL-4 signaling in the setting of infection or allergic responses can drive Type 2 inflammation. IL-25 requires the IL-17 receptor B (IL-17Rb) to mediate signaling through nuclear factor kappa B transcriptional activation. Despite the known coexistence of these two cytokines in the Type 2 inflammatory environment, collaborative signaling between the IL-4 and IL-25 axes is poorly explored. Here we demonstrate IL-4 induction of both IL-25 and IL-17Rb protein in human lung tissue culture, primary alveolar macrophages, and the THP-1 monocytic cell line...
April 19, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28355561/pneumocystis-driven-inducible-bronchus-associated-lymphoid-tissue-formation-requires-th2-and-th17-immunity
#2
Taylor Eddens, Waleed Elsegeiny, Maria de la Luz Garcia-Hernadez, Patricia Castillo, Giraldina Trevejo-Nunez, Katelin Serody, Brian T Campfield, Shabaana A Khader, Kong Chen, Javier Rangel-Moreno, Jay K Kolls
Inducible bronchus-associated lymphoid tissue (iBALT) is an ectopic lymphoid structure composed of highly organized T cell and B cell zones that forms in the lung in response to infectious or inflammatory stimuli. Here, we develop a model for fungal-mediated iBALT formation, using infection with Pneumocystis that induces development of pulmonary lymphoid follicles. Pneumocystis-dependent iBALT structure formation and organization required CXCL13 signaling. Cxcl13 expression was regulated by interleukin (IL)-17 family members, as Il17ra(-/-), Il17rb(-/-), and Il17rc(-/-) mice failed to develop iBALT...
March 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/28160754/the-role-of-il17b-il17rb-signaling-pathway-in-breast-cancer
#3
REVIEW
Vahideh Alinejad, Sanam Dolati, Morteza Motallebnezhad, Mehdi Yousefi
Breast cancer is the most important cause of death in women globally. Though, improved survival is due to the developments in the screening techniques, initial diagnosis, and advances in treatments. Numerous factors contributed in the progression of breast cancer, such as inflammation. The most significant factor involved in the inflammatory process, is T helper 17 (Th17) cells. Th17 cells have an exceptional role in many of inflammatory diseases like psoriasis, rheumatoid arthritis, and breast cancer through production of proinflammatory cytokine (IL17)...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27973603/mucosal-expression-of-t-cell-gene-variants-is-associated-with-differential-resistance-to-teladorsagia-circumcincta
#4
Hazel Wilkie, Louise Nicol, Anton Gossner, John Hopkins
Resistance of sheep to the gastrointestinal nematode Teladorsagia circumcincta is a heritable characteristic. Control of parasite colonization and egg production is strongly linked to IgA antibody levels regulated by Th2 T cell activation within lymphoid tissue; and persistently-infected susceptible animals develop an inflammatory Th1/Th17 response within the abomasum that fails to control infection. Differential T cell polarization therefore is associated with parasite resistance and/or susceptibility and is controlled by a specific set of transcription factors and cytokine receptors...
2016: PloS One
https://www.readbyqxmd.com/read/27925343/transplantation-of-thy1-cells-accelerates-liver-regeneration-by-enhancing-the-growth-of-small-hepatocyte-like-progenitor-cells-via-il17rb-signaling
#5
Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Junko Kon, Yusuke Yoshioka, Takahiro Ochiya, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka
Small hepatocyte-like progenitor cells (SHPCs) transiently form clusters in rat livers treated with retrorsine (Ret)/70% partial hepatectomy (PH). When Thy1(+) cells isolated from d-galactosamine-treated rat livers were transplanted into the livers of Ret/PH-treated rats, the mass of the recipient liver transiently increased during the first 30 days after transplantation, suggesting that liver regeneration was enhanced. Here we addressed how Thy1(+) cell transplantation stimulates liver regeneration. We found that the number and size of SHPC clusters increased in the liver at 14 days after transplantation...
December 7, 2016: Stem Cells
https://www.readbyqxmd.com/read/27620722/critical-role-for-interleukin-25-in-host-protective-th2-memory-response-against-heligmosomoides-polygyrus-bakeri
#6
Chenlin Pei, Chao Zhao, An-Jiang Wang, Anya X Fan, Viktoriya Grinchuk, Allen Smith, Rex Sun, Yue Xie, Nonghua Lu, Joseph F Urban, Terez Shea-Donohue, Aiping Zhao, Zhonghan Yang
Infection with parasitic nematodes, especially gastrointestinal geohelminths, affects hundreds of millions of people worldwide and thus poses a major risk to global health. The host mechanism of defense against enteric nematode infection remains to be fully understood, but it involves a polarized type 2 immunity leading to alterations in intestinal function that facilitate worm expulsion. We investigated the role of interleukin-25 (IL-25) in host protection against Heligmosomoides polygyrus bakeri infection in mice...
December 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27462789/il-17e-synergizes-with-egf-and-confers-in-vitro-resistance-to-egfr-targeted-therapies-in-tnbc-cells
#7
Yacine Merrouche, Joseph Fabre, Herve Cure, Christian Garbar, Camille Fuselier, Jeremy Bastid, Frank Antonicelli, Reem Al-Daccak, Armand Bensussan, Jerome Giustiniani
Estrogen receptor-, progesterone receptor- and HER2-negative breast cancers, also known as triple-negative breast cancers (TNBCs), have poor prognoses and are refractory to current therapeutic agents, including epidermal growth factor receptor (EGFR) inhibitors. Resistance to anti-EGFR therapeutic agents is often associated with sustained kinase phosphorylation, which promotes EGFR activation and translocation to the nucleus and prevents these agents from acting on their targets. The mechanisms underlying this resistance have not been fully elucidated...
August 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27372407/co-delivery-of-il17rb-sirna-and-doxorubicin-by-chitosan-based-nanoparticles-for-enhanced-anticancer-efficacy-in-breast-cancer-cells
#8
Vahideh Alinejad, Mohammad Hossein Somi, Behzad Baradaran, Parvin Akbarzadeh, Fatemeh Atyabi, Hanif Kazerooni, Hosein Samadi Kafil, Leili Aghebati Maleki, Homayoon Siah Mansouri, Mehdi Yousefi
Overexpression of IL17RB is associated with poor prognosis and short survival of the breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in the cell growth, proliferation and migration through the activation of NF-κB as well as the up-regulation of the Bcl-2. In this study we designed carboxymethyl dextran (CMD) Chitosan nanoparticles (ChNPs) to encapsulated IL17RB siRNA and doxorubicin (DOX) as an anticancer drug. Then we investigated the efficiency of the simultaneous delivery of drug/siRNA on viability and gene expression of MDA-MB361 cell lines...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27146030/endometrial-mesenchymal-stem-stromal-cells-their-fibroblast-progeny-in-endometriosis-and-more
#9
Caroline E Gargett, Shanti Gurung
No abstract text is available yet for this article.
June 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/26861902/variations-in-il-23-and-il-25-receptor-gene-structure-sequence-and-expression-associated-with-the-two-disease-forms-of-sheep-paratuberculosis
#10
Louise Nicol, Anton Gossner, Craig Watkins, Francesca Chianini, Robert Dalziel, John Hopkins
The immunopathology of paucibacillary and multibacillary sheep paratuberculosis is characterized by inflammatory T cell and macrophage responses respectively. IL-23 and IL-25 are key to the development of these responses by interaction with their complex receptors, IL-23R/IL-12RB1 and IL-17RA/IL-17RB. In humans, variations in structure, sequence and/or expression of these genes have been implicated in the different pathological forms of tuberculosis and leprosy, and in gastrointestinal inflammatory disorders such as Crohn's disease...
February 9, 2016: Veterinary Research
https://www.readbyqxmd.com/read/26560039/il-25-and-cd4-th2-cells-enhance-type-2-innate-lymphoid-cell-derived-il-13-production-which-promotes-ige-mediated-experimental-food-allergy
#11
Jee-Boong Lee, Chun-Yu Chen, Bo Liu, Luke Mugge, Pornpimon Angkasekwinai, Valeria Facchinetti, Chen Dong, Yong-Jun Liu, Marc E Rothenberg, Simon P Hogan, Fred D Finkelman, Yui-Hsi Wang
BACKGROUND: Food-mediated allergic reactions have emerged as a major health problem. The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary allergens in the gastrointestinal tract remain elusive. OBJECTIVE: We investigated whether altering IL-25 signaling enhances or attenuates allergic responses to food allergens. METHODS: Mice of an IL-25 transgenic mouse line (iIL-25Tg mice), which constitutively overexpress intestinal IL-25, and Il17rb(-/-) mice, in which Il17rb gene expression is disrupted, were sensitized and gavage fed with ovalbumin (OVA)...
April 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26479384/relationships-between-circulating-urea-concentrations-and-endometrial-function-in-postpartum-dairy-cows
#12
Zhangrui Cheng, Chike F Oguejiofor, Theerawat Swangchan-Uthai, Susan Carr, D Claire Wathes
Both high and low circulating urea concentrations, a product of protein metabolism, are associated with decreased fertility in dairy cows through poorly defined mechanisms. The rate of involution and the endometrial ability to mount an adequate innate immune response after calving are both critical for subsequent fertility. Study 1 used microarray analysis to identify genes whose endometrial expression 2 weeks postpartum correlated significantly with the mean plasma urea per cow, ranging from 3.2 to 6.6 mmol/L...
August 14, 2015: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/25484349/association-between-interleukin-17-interleukin-17-receptor-gene-polymorphisms-and-papillary-thyroid-cancer-in-korean-population
#13
Young Chan Lee, Joo-Ho Chung, Su Kang Kim, Sang Youl Rhee, Suk Chon, Seung Joon Oh, Il Ki Hong, Young Gyu Eun
BACKGROUND: Although numerous recent studies have implicated a role for interleukin 17(IL17) in tumor development, the mechanisms of IL17 involvement are still uncharacterized. The aims of this study were to determine whether single nucleotide polymorphisms (SNPs) in IL17 and IL17R contribute to the development of papillary thyroid cancer (PTC) and to assess the relationship between IL17 and IL17R SNPs and the clinicopathologic characteristics of PTC. MATERIALS AND METHODS: Eight SNPs located within the IL17A, IL17RA, and IL17RB genes were genotyped using direct sequencing in 94 patients with PTC and 260 patients without PTC (controls)...
February 2015: Cytokine
https://www.readbyqxmd.com/read/25379667/fluorescently-activated-cell-sorting-followed-by-microarray-profiling-of-helper-t-cell-subtypes-from-human-peripheral-blood
#14
Chiaki Ono, Zhiqian Yu, Yoshiyuki Kasahara, Yoshie Kikuchi, Naoto Ishii, Hiroaki Tomita
BACKGROUND: Peripheral blood samples have been subjected to comprehensive gene expression profiling to identify biomarkers for a wide range of diseases. However, blood samples include red blood cells, white blood cells, and platelets. White blood cells comprise polymorphonuclear leukocytes, monocytes, and various types of lymphocytes. Blood is not distinguishable, irrespective of whether the expression profiles reflect alterations in (a) gene expression patterns in each cell type or (b) the proportion of cell types in blood...
2014: PloS One
https://www.readbyqxmd.com/read/25172496/gata-3-dose-dependent-checkpoints-in-early-t-cell-commitment
#15
Deirdre D Scripture-Adams, Sagar S Damle, Long Li, Koorosh J Elihu, Shuyang Qin, Alexandra M Arias, Robert R Butler, Ameya Champhekar, Jingli A Zhang, Ellen V Rothenberg
GATA-3 expression is crucial for T cell development and peaks during commitment to the T cell lineage, midway through the CD4(-)CD8(-) (double-negative [DN]) stages 1-3. We used RNA interference and conditional deletion to reduce GATA-3 protein acutely at specific points during T cell differentiation in vitro. Even moderate GATA-3 reduction killed DN1 cells, delayed progression to the DN2 stage, skewed DN2 gene regulation, and blocked appearance of the DN3 phenotype. Although a Bcl-2 transgene rescued DN1 survival and improved DN2 cell generation, it did not restore DN3 differentiation...
October 1, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/23810766/il-33-is-more-potent-than-il-25-in-provoking-il-13-producing-nuocytes-type-2-innate-lymphoid-cells-and-airway-contraction
#16
Jillian L Barlow, Samantha Peel, Jane Fox, Veera Panova, Clare S Hardman, Ana Camelo, Christine Bucks, Xiaoying Wu, Colleen M Kane, Daniel R Neill, Robin J Flynn, Ian Sayers, Ian P Hall, Andrew N J McKenzie
BACKGROUND: IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse studies suggest their immunologic functions in type 2 immunity are almost entirely overlapping. However, only polymorphisms in the IL-33 pathway (IL1RL1 and IL33) have been significantly associated with asthma in large-cohort genome-wide association studies. OBJECTIVE: We sought to identify distinct pathways for IL-25 and IL-33 in the lung that might provide insight into their roles in asthma pathogenesis and potential for therapeutic intervention...
October 2013: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/23438959/novel-monocyte-biomarkers-of-atherogenic-conditions
#17
REVIEW
Alexei Gratchev, Ilja Ovsiy, Ioannis Manousaridis, Vladimir Riabov, Alexander Orekhov, Julia Kzhyshkowska
Hidden low grade inflammation underlines various cardio-metabolic diseases. This type of inflammation is triggered by abnormal reaction to unwanted self products or deregulation of cellular response to cytokines. In the case of atherosclerosis hidden inflammation is induced by modified lipoproteins and develops under control of different cytokines including IL-4 and TGFβ. The key innate immune cells reacting on these factors are monocytes and macrophages. It is well established that monocytes represent a heterogeneous cell population that easily reacts to pathologic changes in the organism...
2013: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/23285118/dna-methylation-in-multiple-myeloma-is-weakly-associated-with-gene-transcription
#18
Sungwon Jung, Seungchan Kim, Molly Gale, Irene Cherni, Rafael Fonseca, John Carpten, Bodour Salhia
Previous studies have now demonstrated that both genic and global hypomethylation characterizes the multiple myeloma (MM) epigenome. Whether these methylation changes are associated with global and corresponding increases (or decreases) in transcriptional activity are poorly understood. The purpose of our current study was to correlate DNA methylation levels in MM to gene expression. We analyzed matching datasets generated by the GoldenGate methylation BeadArray and Affymetrix gene expression platforms in 193 MM samples...
2012: PloS One
https://www.readbyqxmd.com/read/23147652/gene-polymorphisms-of-interleukin-17-and-interleukin-17-receptor-are-associated-with-end-stage-kidney-disease
#19
Yang-Gyun Kim, Eun-Young Kim, Chun-Gyoo Ihm, Tae-Won Lee, Sang-Ho Lee, Kyung-Hwan Jeong, Ju-Young Moon, Joo-Ho Chung, Yeong-Hoon Kim
BACKGROUND: Inflammation could be a causal factor in progression of chronic kidney disease. To date, there is convincing experimental and clinical evidence to support the notion that interleukin (IL)-17-producing T cells contribute to kidney injury in renal diseases. However, the genetic relationship between end-stage renal disease (ESRD) and the T-helper 17 pathway has never been studied. In this study, we hypothesized that polymorphisms of IL-17 or their receptors may be associated with ESRD...
2012: American Journal of Nephrology
https://www.readbyqxmd.com/read/22543263/interleukin-25-induces-type-2-cytokine-production-in-a-steroid-resistant-interleukin-17rb-myeloid-population-that-exacerbates-asthmatic-pathology
#20
Bryan C Petersen, Alison L Budelsky, Alan P Baptist, Matthew A Schaller, Nicholas W Lukacs
Interleukin-25 (IL-25) is a cytokine associated with allergy and asthma that functions to promote type 2 immune responses at mucosal epithelial surfaces and serves to protect against helminth parasitic infections in the intestinal tract. This study identifies the IL-25 receptor, IL-17RB, as a key mediator of both innate and adaptive pulmonary type 2 immune responses. Allergen exposure upregulated IL-25 and induced type 2 cytokine production in a previously undescribed granulocytic population, termed type 2 myeloid (T2M) cells...
May 2012: Nature Medicine
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