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Chenlin Pei, Chao Zhao, An-Jiang Wang, Anya X Fan, Viktoriya Grinchuk, Allen Smith, Rex Sun, Yue Xie, Nonghua Lu, Joseph F Urban, Terez Shea-Donohue, Aiping Zhao, Zhonghan Yang
Infection with parasitic nematodes, especially gastrointestinal geohelminths, affects hundreds of millions of people worldwide and thus poses a major risk to global health. The host mechanism of defense against enteric nematode infection remains to be fully understood, but it involves a polarized type 2 immunity leading to alterations in intestinal function that facilitate worm expulsion. We investigated the role of interleukin-25 (IL-25) in host protection against Heligmosomoides polygyrus bakeri infection in mice...
December 2016: Infection and Immunity
Yacine Merrouche, Joseph Fabre, Herve Cure, Christian Garbar, Camille Fuselier, Jeremy Bastid, Frank Antonicelli, Reem Al-Daccak, Armand Bensussan, Jerome Giustiniani
Estrogen receptor-, progesterone receptor- and HER2-negative breast cancers, also known as triple-negative breast cancers (TNBCs), have poor prognoses and are refractory to current therapeutic agents, including epidermal growth factor receptor (EGFR) inhibitors. Resistance to anti-EGFR therapeutic agents is often associated with sustained kinase phosphorylation, which promotes EGFR activation and translocation to the nucleus and prevents these agents from acting on their targets. The mechanisms underlying this resistance have not been fully elucidated...
July 23, 2016: Oncotarget
Vahideh Alinejad, Mohammad Hossein Somi, Behzad Baradaran, Parvin Akbarzadeh, Fatemeh Atyabi, Hanif Kazerooni, Hosein Samadi Kafil, Leili Aghebati Maleki, Homayoon Siah Mansouri, Mehdi Yousefi
Overexpression of IL17RB is associated with poor prognosis and short survival of the breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in the cell growth, proliferation and migration through the activation of NF-κB as well as the up-regulation of the Bcl-2. In this study we designed carboxymethyl dextran (CMD) Chitosan nanoparticles (ChNPs) to encapsulated IL17RB siRNA and doxorubicin (DOX) as an anticancer drug. Then we investigated the efficiency of the simultaneous delivery of drug/siRNA on viability and gene expression of MDA-MB361 cell lines...
June 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Caroline E Gargett, Shanti Gurung
No abstract text is available yet for this article.
June 2016: Biology of Reproduction
Louise Nicol, Anton Gossner, Craig Watkins, Francesca Chianini, Robert Dalziel, John Hopkins
The immunopathology of paucibacillary and multibacillary sheep paratuberculosis is characterized by inflammatory T cell and macrophage responses respectively. IL-23 and IL-25 are key to the development of these responses by interaction with their complex receptors, IL-23R/IL-12RB1 and IL-17RA/IL-17RB. In humans, variations in structure, sequence and/or expression of these genes have been implicated in the different pathological forms of tuberculosis and leprosy, and in gastrointestinal inflammatory disorders such as Crohn's disease...
2016: Veterinary Research
Jee-Boong Lee, Chun-Yu Chen, Bo Liu, Luke Mugge, Pornpimon Angkasekwinai, Valeria Facchinetti, Chen Dong, Yong-Jun Liu, Marc E Rothenberg, Simon P Hogan, Fred D Finkelman, Yui-Hsi Wang
BACKGROUND: Food-mediated allergic reactions have emerged as a major health problem. The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary allergens in the gastrointestinal tract remain elusive. OBJECTIVE: We investigated whether altering IL-25 signaling enhances or attenuates allergic responses to food allergens. METHODS: Mice of an IL-25 transgenic mouse line (iIL-25Tg mice), which constitutively overexpress intestinal IL-25, and Il17rb(-/-) mice, in which Il17rb gene expression is disrupted, were sensitized and gavage fed with ovalbumin (OVA)...
April 2016: Journal of Allergy and Clinical Immunology
Zhangrui Cheng, Chike F Oguejiofor, Theerawat Swangchan-Uthai, Susan Carr, D Claire Wathes
Both high and low circulating urea concentrations, a product of protein metabolism, are associated with decreased fertility in dairy cows through poorly defined mechanisms. The rate of involution and the endometrial ability to mount an adequate innate immune response after calving are both critical for subsequent fertility. Study 1 used microarray analysis to identify genes whose endometrial expression 2 weeks postpartum correlated significantly with the mean plasma urea per cow, ranging from 3.2 to 6.6 mmol/L...
August 14, 2015: Animals: An Open Access Journal From MDPI
Young Chan Lee, Joo-Ho Chung, Su Kang Kim, Sang Youl Rhee, Suk Chon, Seung Joon Oh, Il Ki Hong, Young Gyu Eun
BACKGROUND: Although numerous recent studies have implicated a role for interleukin 17(IL17) in tumor development, the mechanisms of IL17 involvement are still uncharacterized. The aims of this study were to determine whether single nucleotide polymorphisms (SNPs) in IL17 and IL17R contribute to the development of papillary thyroid cancer (PTC) and to assess the relationship between IL17 and IL17R SNPs and the clinicopathologic characteristics of PTC. MATERIALS AND METHODS: Eight SNPs located within the IL17A, IL17RA, and IL17RB genes were genotyped using direct sequencing in 94 patients with PTC and 260 patients without PTC (controls)...
February 2015: Cytokine
Chiaki Ono, Zhiqian Yu, Yoshiyuki Kasahara, Yoshie Kikuchi, Naoto Ishii, Hiroaki Tomita
BACKGROUND: Peripheral blood samples have been subjected to comprehensive gene expression profiling to identify biomarkers for a wide range of diseases. However, blood samples include red blood cells, white blood cells, and platelets. White blood cells comprise polymorphonuclear leukocytes, monocytes, and various types of lymphocytes. Blood is not distinguishable, irrespective of whether the expression profiles reflect alterations in (a) gene expression patterns in each cell type or (b) the proportion of cell types in blood...
2014: PloS One
Deirdre D Scripture-Adams, Sagar S Damle, Long Li, Koorosh J Elihu, Shuyang Qin, Alexandra M Arias, Robert R Butler, Ameya Champhekar, Jingli A Zhang, Ellen V Rothenberg
GATA-3 expression is crucial for T cell development and peaks during commitment to the T cell lineage, midway through the CD4(-)CD8(-) (double-negative [DN]) stages 1-3. We used RNA interference and conditional deletion to reduce GATA-3 protein acutely at specific points during T cell differentiation in vitro. Even moderate GATA-3 reduction killed DN1 cells, delayed progression to the DN2 stage, skewed DN2 gene regulation, and blocked appearance of the DN3 phenotype. Although a Bcl-2 transgene rescued DN1 survival and improved DN2 cell generation, it did not restore DN3 differentiation...
October 1, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
Jillian L Barlow, Samantha Peel, Jane Fox, Veera Panova, Clare S Hardman, Ana Camelo, Christine Bucks, Xiaoying Wu, Colleen M Kane, Daniel R Neill, Robin J Flynn, Ian Sayers, Ian P Hall, Andrew N J McKenzie
BACKGROUND: IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse studies suggest their immunologic functions in type 2 immunity are almost entirely overlapping. However, only polymorphisms in the IL-33 pathway (IL1RL1 and IL33) have been significantly associated with asthma in large-cohort genome-wide association studies. OBJECTIVE: We sought to identify distinct pathways for IL-25 and IL-33 in the lung that might provide insight into their roles in asthma pathogenesis and potential for therapeutic intervention...
October 2013: Journal of Allergy and Clinical Immunology
Alexei Gratchev, Ilja Ovsiy, Ioannis Manousaridis, Vladimir Riabov, Alexander Orekhov, Julia Kzhyshkowska
Hidden low grade inflammation underlines various cardio-metabolic diseases. This type of inflammation is triggered by abnormal reaction to unwanted self products or deregulation of cellular response to cytokines. In the case of atherosclerosis hidden inflammation is induced by modified lipoproteins and develops under control of different cytokines including IL-4 and TGFβ. The key innate immune cells reacting on these factors are monocytes and macrophages. It is well established that monocytes represent a heterogeneous cell population that easily reacts to pathologic changes in the organism...
2013: Current Pharmaceutical Design
Sungwon Jung, Seungchan Kim, Molly Gale, Irene Cherni, Rafael Fonseca, John Carpten, Bodour Salhia
Previous studies have now demonstrated that both genic and global hypomethylation characterizes the multiple myeloma (MM) epigenome. Whether these methylation changes are associated with global and corresponding increases (or decreases) in transcriptional activity are poorly understood. The purpose of our current study was to correlate DNA methylation levels in MM to gene expression. We analyzed matching datasets generated by the GoldenGate methylation BeadArray and Affymetrix gene expression platforms in 193 MM samples...
2012: PloS One
Yang-Gyun Kim, Eun-Young Kim, Chun-Gyoo Ihm, Tae-Won Lee, Sang-Ho Lee, Kyung-Hwan Jeong, Ju-Young Moon, Joo-Ho Chung, Yeong-Hoon Kim
BACKGROUND: Inflammation could be a causal factor in progression of chronic kidney disease. To date, there is convincing experimental and clinical evidence to support the notion that interleukin (IL)-17-producing T cells contribute to kidney injury in renal diseases. However, the genetic relationship between end-stage renal disease (ESRD) and the T-helper 17 pathway has never been studied. In this study, we hypothesized that polymorphisms of IL-17 or their receptors may be associated with ESRD...
2012: American Journal of Nephrology
Bryan C Petersen, Alison L Budelsky, Alan P Baptist, Matthew A Schaller, Nicholas W Lukacs
Interleukin-25 (IL-25) is a cytokine associated with allergy and asthma that functions to promote type 2 immune responses at mucosal epithelial surfaces and serves to protect against helminth parasitic infections in the intestinal tract. This study identifies the IL-25 receptor, IL-17RB, as a key mediator of both innate and adaptive pulmonary type 2 immune responses. Allergen exposure upregulated IL-25 and induced type 2 cytokine production in a previously undescribed granulocytic population, termed type 2 myeloid (T2M) cells...
May 2012: Nature Medicine
Anna Popova, Julia Kzhyshkowska, Dinara Nurgazieva, Sergij Goerdt, Alexei Gratchev
IL17RB is the receptor for IL17E, the only member of IL17 family promoting Th2 reactions. The mechanism of IL17BR regulation is poorly understood. We previously demonstrated that expression of IL17RB is induced on human macrophages by IL4 and enhanced by TGFβ. In the present study we investigated the immediate signaling targets of IL17RB. Using Yeast Two Hybrid screening we identified DAZAP2 as a binding partner of IL17RB. We established that 2 SH2-binding domains of DAZAP2 are essential for its binding to IL17RB...
March 2012: Immunobiology
Baojun Wu, Meng Jin, Yi Zhang, Tiandi Wei, Zengliang Bai
The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have been identified in non-mammalian species, such as zebrafish IL17RD; however, there are no reports on the evolutionary history of this complex gene family through comparative phylogenetic approaches. Here, we concentrated on the IL17R evolution in chordates. There are two IL17Rs in the genome of the basal chordate amphioxus: IL17RA and IL17RD...
December 2011: Immunogenetics
Gary M Hunninghake, Jen-hwa Chu, Sunita S Sharma, Michael H Cho, Blanca E Himes, Angela J Rogers, Amy Murphy, Vincent J Carey, Benjamin A Raby
BACKGROUND: The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known. METHODS: Peripheral blood CD4+ T cells from 223 participants from the Childhood Asthma Management Program (CAMP) with simultaneous measurement of IgE. Total RNA was isolated, and expression profiles were generated with Illumina HumanRef8 v2 BeadChip arrays. Modeling of the relationship between genome-wide gene transcript levels and IgE levels was performed in all subjects, and stratified by sex...
2011: BMC Pulmonary Medicine
Yuri Matsumoto, Emiko Noguchi, Yoshimasa Imoto, Kentaro Nanatsue, Kaoru Takeshita, Masanao Shibasaki, Tadao Arinami, Shigeharu Fujieda
BACKGROUND: Seasonal allergic rhinitis (SAR) to Japanese cedar (Cryptomeria japonica; JC) is an IgE-mediated type I allergy affecting the nasal mucosa. However, the molecular mechanisms that underlie SAR are only partially understood. The aim of the study was to identify novel genes related to SAR during natural exposure to pollens, by using microarray analysis. METHODS: Subjects were 32 SAR patients and 25 controls. Total RNA was extracted from CD4(+) T cells isolated from peripheral blood mononuclear cells and subjected to microarray analysis with Illumina Human Ref8 BeadChip arrays...
March 2011: Allergology International: Official Journal of the Japanese Society of Allergology
Marc Le Vee, Elodie Jouan, Olivier Fardel
Aryl hydrocarbon receptor (AhR) is a drug-sensing receptor activated by environmental contaminants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and is known to drive regulation of target genes in various human cell types. Its involvement in TCDD-mediated regulation of target genes in human hepatocytes however remains to be formally demonstrated. To gain insights into this point, we have analyzed the effects of AhR silencing on the regulation of various genes targeted by TCDD in primary human hepatocytes and highly-differentiated human hepatoma HepaRG cells...
September 2010: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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