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juvenile rheumatoid arthritis

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https://www.readbyqxmd.com/read/29781829/comparison-of-adults-with-polyarticular-juvenile-idiopathic-arthritis-to-adults-with-rheumatoid-arthritis-a-cross-sectional-analysis-of-clinical-features-and-medication-use
#1
Danielle M Feger, Nicholas Longson, Hiranda Dodanwala, Barbara E Ostrov, Nancy J Olsen, Rayford R June
BACKGROUND/OBJECTIVE: Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. METHODS: We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017...
May 17, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29766247/current-status-of-wrist-imaging-in-juvenile-idiopathic-arthritis
#2
REVIEW
Derk Frederik Matthaus Avenarius, Charlotte Nusman, Clara Malattia, Laura Tanturri de Horatio, Karen Rosendahl, Mario Maas, Lil-Sofie Ording Müller
Wrist involvement occurs in about one-quarter of patients diagnosed with juvenile idiopathic arthritis (JIA), increasing to 40% 5 years after diagnosis. The imaging appearances, both for active inflammation and permanent change, differ from those seen in adult rheumatoid arthritis; therefore, a child-specific approach is crucial for correct assessment. In this review article, we provide an update on the current status for imaging wrist JIA, with a focus on evidence-based practice.
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29743634/replication-study-of-polymorphisms-associated-with-response-to-methotrexate-in-patients-with-rheumatoid-arthritis
#3
Rosario López-Rodríguez, Aida Ferreiro-Iglesias, Aurea Lima, Miguel Bernardes, Andrzej Pawlik, Agnieszka Paradowska-Gorycka, Jerzy Świerkot, Ryszard Slezak, Vita Dolžan, Isidoro González-Álvaro, Javier Narváez, Rafael Cáliz, Eva Pérez-Pampín, Antonio Mera-Varela, Laura Vidal-Bralo, José Gorgonio Acuña Ochoa, Carmen Conde, Juan J Gómez-Reino, Antonio González
About 70 genetic studies have already addressed the need of biomarkers to predict the response of patients with rheumatoid arthritis (RA) to methotrexate (MTX) treatment. However, no genetic biomarker has yet been sufficiently validated. Here, we aimed to replicate a selection of 25 SNPs in the largest collection of patients up to date, which consisted of 915 patients treated with MTX. The change in disease activity (measured as ΔDAS28) from baseline was considered the primary outcome. In addition, response according to widely used criteria (EULAR) was taken as secondary outcome...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29717035/predictors-of-flare-following-etanercept-withdrawal-in-patients-with-rheumatoid-factor-negative-juvenile-idiopathic-arthritis-who-reached-remission-while-taking-medication
#4
Angela Aquilani, Denise Pires Marafon, Emiliano Marasco, Rebecca Nicolai, Virginia Messia, Francesca Perfetti, Silvia Magni-Manzoni, Fabrizio De Benedetti
OBJECTIVE: To evaluate the rate of flare after etanercept (ETN) withdrawal in patients with juvenile idiopathic arthritis (JIA) who attained clinical remission while taking medication, and to identify predictors of flare. METHODS: Patients were included with oligo- (oJIA) and rheumatoid factor-negative polyarticular JIA (pJIA) who received a first course of ETN for at least 18 months, maintained clinically inactive disease (CID) for at least 6 months during treatment, and were followed for 12 months after ETN withdrawal...
May 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29703372/50-years-ago-in-the-journal-of-pediatrics-rash-associated-with-juvenile-rheumatoid-arthritis
#5
Philip J Hashkes
No abstract text is available yet for this article.
May 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29662164/transcription-factors-operate-across-disease-loci-with-ebna2-implicated-in-autoimmunity
#6
John B Harley, Xiaoting Chen, Mario Pujato, Daniel Miller, Avery Maddox, Carmy Forney, Albert F Magnusen, Arthur Lynch, Kashish Chetal, Masashi Yukawa, Artem Barski, Nathan Salomonis, Kenneth M Kaufman, Leah C Kottyan, Matthew T Weirauch
Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors (TFs) occupy multiple loci associated with individual complex genetic disorders. Application to 213 phenotypes and 1,544 TF binding datasets identified 2,264 relationships between hundreds of TFs and 94 phenotypes, including androgen receptor in prostate cancer and GATA3 in breast cancer. Strikingly, nearly half of systemic lupus erythematosus risk loci are occupied by the Epstein-Barr virus EBNA2 protein and many coclustering human TFs, showing gene-environment interaction...
April 16, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29648683/long-term-outcomes-following-achievement-of-clinically-inactive-disease-in-juvenile-idiopathic-arthritis-the-importance-of-definition
#7
Stephanie Jw Shoop-Worrall, Suzanne Mm Verstappen, Janet E McDonagh, Eileen Baildam, Alice Chieng, Joyce Davidson, Helen Foster, Yiannis Ioannou, Flora McErlane, Lucy R Wedderburn, W Thomson, Kimme L Hyrich
BACKGROUND: Potential targets for treat-to-target strategies in JIA are minimal disease activity (MDA) and clinically inactive disease (CID). Short and long-term outcomes following achievement of MDA and CID on the cJADAS10 and CID on Wallace's preliminary criteria were compared. METHODS: Children recruited to the Childhood Arthritis Prospective Study, a UK multicentre inception cohort, were selected if recruited prior to January 2011 and diagnosed with oligoarthritis or rheumatoid factor negative or positive polyarthritis...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29618462/allogeneic-hematopoietic-stem-cell-transplantation-for-severe-refractory-juvenile-idiopathic-arthritis
#8
Juliana M F Silva, Fani Ladomenou, Ben Carpenter, Sharat Chandra, Petr Sedlacek, Renata Formankova, Vicky Grandage, Mark Friswell, Andrew J Cant, Zohreh Nademi, Mary A Slatter, Andrew R Gennery, Sophie Hambleton, Terence J Flood, Giovanna Lucchini, Robert Chiesa, Kanchan Rao, Persis J Amrolia, Paul Brogan, Lucy R Wedderburn, Julie M Glanville, Rachael Hough, Rebecca Marsh, Mario Abinun, Paul Veys
Patients with juvenile idiopathic arthritis (JIA) can experience a severe disease course, with progressive destructive polyarthritis refractory to conventional therapy with disease-modifying antirheumatic drugs including biologics, as well as life-threatening complications including macrophage activation syndrome (MAS). Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative immunomodulatory strategy for patients with such refractory disease. We treated 16 patients in 5 transplant centers between 2007 and 2016: 11 children with systemic JIA and 5 with rheumatoid factor-negative polyarticular JIA; all were either refractory to standard therapy, had developed secondary hemophagocytic lymphohistiocytosis/MAS poorly responsive to treatment, or had failed autologous HSCT...
April 10, 2018: Blood Advances
https://www.readbyqxmd.com/read/29606669/flares-of-disease-in-children-with-clinically-inactive-juvenile-idiopathic-arthritis-were-not-correlated-with-ultrasound-findings
#9
Yongdong Zhao, Nanci E Rascoff, Ramesh S Iyer, Mahesh Thapa, Lucas Reichley, Assaf P Oron, Carol A Wallace
OBJECTIVE: The validity of our current definitions for clinically inactive disease (CID) in juvenile idiopathic arthritis (JIA) based on physical examination is challenged by the development of advanced musculoskeletal imaging tools. We aimed to prospectively determine the prevalence of abnormal ultrasound (US) findings in children with CID in JIA and their clinical significance. METHODS: Children aged ≥ 4 years with CID and a history of arthritis from a single tertiary center were approached over 1 year...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29582130/conventional-radiography-in-juvenile-idiopathic-arthritis-joint-recommendations-from-the-french-societies-for-rheumatology-radiology-and-paediatric-rheumatology
#10
Pauline Marteau, Catherine Adamsbaum, Linda Rossi-Semerano, Michel De Bandt, Irène Lemelle, Chantal Deslandre, Tu Anh Tran, Anne Lohse, Elisabeth Solau-Gervais, Christelle Sordet, Pascal Pillet, Brigitte Bader-Meunier, Julien Wipff, Cécile Gaujoux-Viala, Sylvain Breton, Valérie Devauchelle-Pensec
BACKGROUND: Juvenile idiopathic arthritis (JIA) can cause structural damage. However, data on conventional radiography (CR) in JIA are scant. OBJECTIVE: To provide pragmatic guidelines on CR in each non-systemic JIA subtype. METHODS: A multidisciplinary task force of 16 French experts (rheumatologists, paediatricians, radiologists and one patient representative) formulated research questions on CR assessments in each non-systemic JIA subtype...
March 26, 2018: European Radiology
https://www.readbyqxmd.com/read/29576918/nonspanning-total-wrist-arthrodesis-with-a-low-profile-locking-plate
#11
Schneider K Rancy, Eugene T Ek, Sophia Paul, Robert N Hotchkiss, Scott W Wolfe
Purpose  This study aims to compare the outcomes and complications of our technique for nonspanning total wrist arthrodesis using a locking plate with the standard carpometacarpal spanning technique. Methods  A retrospective review of charts was performed to identify patients who underwent total wrist arthrodesis by the senior author (S.W.W.). We compared the outcomes of 15 cases of nonspanning wrist fusion with a 2.4/2.7 mm locking T plate to 11 cases of spanning wrist fusion with a 2.7/3.5 mm locking compression plate...
April 2018: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29574865/rheumatologic-complications-in-a-cohort-of-227-patients-with-common-variable-immunodeficiency
#12
Gholamreza Azizi, Fatemeh Kiaee, Ehsan Hedayat, Reza Yazdani, Elahe Dolatshahi, Tina Alinia, Laleh Sharifi, Hamed Mohammadi, Hoda Kavosi, Farhad Jadidi-Niaragh, Vahid Ziaee, Hassan Abolhassani, Asghar Aghamohammadi
INTRODUCTION: Common variable immunodeficiency (CVID) is the most prevalent symptomatic type of human primary immunodeficiency diseases (PID). Clinically, CVID is characterized by increased susceptibility to infections and a wide variety of autoimmune and rheumatologic disorders. METHODS: All CVID patients registered in Iranian PID Registry (IPIDR) were enrolled in this retrospective cohort study. We investigated the frequency of rheumatologic diseases and its association with immunological and clinical phenotypes in CVID patients...
March 24, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29573557/the-correlation-between-the-childhood-health-assessment-questionnaire-and-disease-activity-in-juvenile-idiopathic-arthritis
#13
Watchareewan Sontichai, Soamarat Vilaiyuk
BACKGROUND: The Childhood Health Assessment Questionnaire (CHAQ) has been adapted from the Stanford Health Assessment Questionnaire for assessing functional ability in children. The present study aimed to determine the correlation between CHAQ and disease activity in juvenile idiopathic arthritis (JIA) during active and inactive disease. METHODS: JIA patients in the Pediatric Department, Ramathibodi Hospital, between January 2011 and December 2013, were included in the study...
March 24, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29570475/tocilizumab-in-giant-cell-arteritis
#14
Vincent J Mariano, William H Frishman
Giant cell arteritis is a granulomatous immune-mediated vasculitis of medium and large vessels. It most commonly affects Caucasian females over the age of 50 and is the most common primary vasculitis in the United States. Treatment of this disease has classically been with high-dose corticosteroids, but this therapy has been associated with severe morbidity and mortality. Tocilizumab, a humanized monoclonal antibody targeting the interleukin-6 receptor, has been used with great efficacy and safety in rheumatoid arthritis and systemic-onset juvenile idiopathic arthritis...
March 22, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29556750/the-effect-of-interactive-digital-interventions-on-physical-activity-in-people-with-inflammatory-arthritis-a-systematic-review
#15
REVIEW
Alison J Griffiths, Claire M White, Peter K Thain, Lindsay M Bearne
The aim of this systematic review was to evaluate the evidence from randomised controlled trials (RCTs) evaluating the effectiveness of interactive digital interventions (IDIs) for physical activity (PA) and health related quality of life (HRQoL) in people with Inflammatory Arthritis [rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) axial Spondyloarthritis (AS) and psoriatic arthritis (PsA)]. Seven electronic databases identified published and unpublished studies. Two reviewers conducted independent data extraction and quality assessment using the Cochrane risk of bias tool (RoB)...
March 19, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29538382/a-systematic-review-of-randomised-controlled-trials-assessing-effectiveness-of-prosthetic-and-orthotic-interventions
#16
Aoife Healy, Sybil Farmer, Anand Pandyan, Nachiappan Chockalingam
BACKGROUND: Assistive products are items which allow older people and people with disabilities to be able to live a healthy, productive and dignified life. It has been estimated that approximately 1.5% of the world's population need a prosthesis or orthosis. OBJECTIVE: The objective of this study was to systematically identify and review the evidence from randomized controlled trials assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions...
2018: PloS One
https://www.readbyqxmd.com/read/29502236/a-review-of-recent-advances-using-tocilizumab-in-the-treatment-of-rheumatic-diseases
#17
REVIEW
Andrea Rubbert-Roth, Daniel E Furst, Jan Michael Nebesky, Angela Jin, Erhan Berber
Tocilizumab (TCZ) is the first humanized anti-interleukin-6 (IL-6) receptor monoclonal antibody approved for the treatment of patients with rheumatoid arthritis (RA), Castleman's disease, polyarticular and systemic juvenile idiopathic arthritis, and, most recently, giant cell arteritis as well as for the treatment of chimeric antigen receptor T cell therapy-induced cytokine release syndrome. The global clinical development program for TCZ provides a wealth of clinical data on intravenous TCZ, and more recent studies in patients with RA have provided evidence characterizing the role of intravenous TCZ as monotherapy in early disease and led to the introduction of a subcutaneous formulation of TCZ...
June 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29454012/immunologic-effects-of-chronic-administration-of-tofacitinib-a-janus-kinase-inhibitor-in-cynomolgus-monkeys-and-rats-comparison-of-juvenile-and-adult-responses
#18
Mark Collinge, Douglas J Ball, Christopher J Bowman, Andrea L Nilson, Zaher A Radi, W Mark Vogel
Tofacitinib, an oral Janus kinase (JAK) inhibitor for treatment of rheumatoid arthritis, targets JAK1, JAK3, and to a lesser extent JAK2 and TYK2. JAK1/3 inhibition impairs gamma common chain cytokine receptor signaling, important in lymphocyte development, homeostasis and function. Adult and juvenile cynomolgus monkey and rat studies were conducted and the impact of tofacitinib on immune parameters (lymphoid tissues and lymphocyte subsets) and function (T-dependent antibody response (TDAR), mitogen-induced T cell proliferation) assessed...
April 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29439723/is-palindromic-rheumatism-amongst-children-a-benign-disease
#19
Yonatan Butbul-Aviel, Yosef Uziel, Nofar Hezkelo, Riva Brik, Gil Amarilyo
BACKGROUND: Palindromic rheumatism is an idiopathic, periodic arthritis characterized by multiple, transient, recurring episodes. Palindromic rheumatism is well-characterized in adults, but has never been reported in pediatric populations. The aim of this study was to characterize the clinical features and outcomes of a series of pediatric patients with palindromic rheumatism. METHODS: We defined clinical criteria for palindromic rheumatism and reviewed all clinical visits in three Pediatric Rheumatology centers in Israel from 2006through 2015, to identify patients with the disease...
February 13, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29437586/baseline-ultrasound-examination-as-possible-predictor-of-relapse-in-patients-affected-by-juvenile-idiopathic-arthritis-jia
#20
Orazio De Lucia, Viviana Ravagnani, Francesca Pregnolato, Arvena Hila, Irene Pontikaki, Maurizio Gattinara, Micol Romano, Valeria Gerloni, Sara Pieropan, Antonella Murgo, Maurizio Rossini, Rolando Cimaz, Pier Luigi Meroni
OBJECTIVES: To define the correlation between joint ultrasonography and clinical examination in patients with juvenile idiopathic arthritis (JIA) and to assess whether synovitis detected by ultrasonography in clinically inactive patients predicts arthritis flares. METHODS: 88 consecutive patients with JIA-46 (52%) with persistent oligoarthritis, 15 (17%) with extended oligoarthritis, 15 (17%) with rheumatoid factor-negative polyarthritis and 12 (14%) with other forms of JIA, all clinically inactive for a minimum of 3 months-underwent ultrasound (US) assessment of 44 joints...
February 6, 2018: Annals of the Rheumatic Diseases
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