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https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#1
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29159873/orthopaedic-manifestations-within-the-22q11-2-deletion-syndrome-a-systematic-review
#2
Jelle F Homans, Isabel N Tromp, Dino Colo, Tom P C Schlösser, Moyo C Kruyt, Vincent F X Deeney, Terrence B Crowley, Donna M McDonald-McGinn, René M Castelein
The 22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion syndrome with an estimated prevalence of 1:4,000 live births. 22q11.2DS is known to have wide phenotypic variability, including orthopaedic manifestations. The purpose of this systematic review is to increase the awareness of orthopaedic manifestations associated with 22q11.2DS. This systematic review was performed according to the PRISMA Guidelines. Original epidemiological studies on the prevalence of orthopaedic manifestations within 22q11...
November 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29157059/90k-immunostimulatory-glycoprotein-in-children-with-juvenile-idiopathic-arthritis
#3
Cristina Cecamore, Manuela Marsili, Roberta Salvatore, Roberto Troiani, Maurizia D'Egidio, Nicola Tinari, Piernicola Pelliccia, Francesco Chiarelli, M Loredana Marcovecchio, Luciana Breda
OBJECTIVES: To assess whether circulating levels of 90K glycoprotein are increased in children with juvenile idiopathic arthritis (JIA) at different stages of the disease, compared to healthy controls and to evaluate potential over time changes in its concentrations following treatment with the antitumor-necrosis factor (TNF) drug etanercept. METHODS: 90K glycoprotein, C-reactive protein, erythrocyte sedimentation rate, TNF, antinuclear antibodies, rheumatoid factor and the Juvenile Arthritis Disease Activity Score were assessed in 71 children: 23 with newly diagnosed JIA, 23 with established and active JIA and 25 healthy controls...
November 20, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29153241/treatment-of-the-temporomandibular-joint-in-a-child-with-juvenile-idiopathic-arthritis
#4
REVIEW
Eric J Granquist
The oral and maxillofacial surgeon is instrumental in the management and care of pediatric patients with juvenile idiopathic arthritis (JIA) and should include JIA in the differential when evaluating pediatric patients with temporomandibular joint (TMJ) dysfunction. Medical management has largely decreased the need for surgical intervention, but these patients may require intraarticular steroid injections of the TMJ, close follow-up to monitor their facial growth, and management of the subsequent postinflammatory degenerative TMJ changes...
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29153240/acquired-abnormalities-of-the-temporomandibular-joint
#5
REVIEW
Anne-Frédérique Chouinard, Leonard B Kaban, Zachary S Peacock
Mandibular growth is a complex process that involves the "functional matrix," an interaction of the muscles of mastication, occlusion, and jaw function. Although not a typical growth center, the mandibular condyle has a significant effect on the ultimate size, shape and function of the mandible and secondarily on overall facial form. Acquired temporomandibular joint (TMJ)/condylar abnormalities, such as juvenile idiopathic arthritis, idiopathic condylar resorption, TMJ ankylosis, and condylar hyperplasia, often result in facial deformity and functional deficits...
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29148422/anti-adalimumab-antibodies-in-juvenile-idiopathic-arthritis-related-uveitis
#6
Sanna T Leinonen, Kristiina Aalto, Kaisu M Kotaniemi, Tero T Kivelä
OBJECTIVES: To evaluate the association of adalimumab trough levels and anti-adalimumab antibodies with activity of uveitis in juvenile idiopathic arthritis-related uveitis. METHODS: This was a retrospective observational case series in a clinical setting at the Department of Ophthalmology, Helsinki University Hospital, Finland in 2014-2016. Thirty-one paediatric patients with chronic anterior juvenile idiopathic arthritis-related uveitis in 58 eyes and who had been on adalimumab ≥6 months were eligible for the study...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29145334/concurrent-one-stage-total-knee-and-hip-arthroplasty-due-to-sequel-of-juvenile-rheumatoid-arthritis-a-case-report
#7
Afshin Taheriazam, Amin Saeidinia
RATIONALE: Rheumatoid arthritis is a chronic systemic connective tissue disease. Total hip and knee arthroplasties are common major orthopaedic procedures worldwide. PATIENT CONCERNS: To date, no studies have presented 1-stage concurrent total hip arthroplasty (THA) and total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA). We reported a case which is, to our knowledge, the first description of both THA and TKA in a patient with RA simultaneously...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143927/update-on-the-treatment-of-uveitis-in-patients-with-juvenile-idiopathic-arthritis-a-review
#8
REVIEW
Ioannis Asproudis, Andreas Katsanos, Nikolaos Kozeis, Alexandra Tantou, Anastasios G Konstas
Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until ocular complications arise. The risk of uveitis is increased in girls with an early onset of oligoarthritis and positive antinuclear antibodies. Even though the inflammation in patients with juvenile idiopathic arthritis is initially limited in the anterior part of the eye, chronic active inflammation may eventually cause significant damage to the posterior pole...
November 16, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29142039/risk-factors-associated-with-juvenile-idiopathic-arthritis-exposure-to-cigarette-smoke-and-air-pollution-from-pregnancy-to-disease-diagnosis
#9
Camila Maria Paiva França, Adriana Maluf Elias Sallum, Alfésio Luis Ferreira Braga, Fernando Louzada Strufaldi, Clovis Artur Almeida Silva, Sylvia Costa Lima Farhat
OBJECTIVE: To evaluate exposure to environmental factors inhaled during pregnancy and after birth until juvenile idiopathic arthritis (JIA) diagnosis among residents of a large city. METHODS: This is an exploratory case-control study that consists of 66 patients with JIA and 124 healthy controls matched by age and sex, living in the São Paulo, Brazil, metropolitan area until JIA diagnosis, and whose mothers had resided in this region during pregnancy. A structured and reliable questionnaire (κ index for test-retest was 0...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29142026/a-systematic-review-of-quality-measures-for-inflammatory-arthritis
#10
Matthew Cooper, Azin Rouhi, Claire E H Barber
OBJECTIVE: To conduct a systematic review and quality appraisal of quality measures for inflammatory arthritis, including rheumatoid arthritis (RA), spondyloarthritis, psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA). METHODS: Embase, MEDLINE, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) were searched from January 1, 2000, to October 23, 2016, using Medical Subject Headings terms for inflammatory arthritis and quality measures...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29141313/-tocilizumab-for-refractory-systemic-juvenile-idiopathic-arthritis
#11
J M Lai, F Q Wu, Z X Zhou, M Kang, X L Huang, G X Su, S N Li, J Zhu, X N Wang
Objective: To evaluate the efficacy and side effects of tocilizumab for the treatment of systemic juvenile idiopathic arthritis. Method: In this prospective self case-control study, the children diagnosed with refractory systemic juvenile idiopathic arthritis admitted to Department of Rheumatism and Immunology of Children's Hospital Affiliated to Capital Institute of Pediatrics from December 2013 to June 2016 were enrolled and information before and after treatment of tocilizumab was analyzed. The tocilizumab was introvenously guttae in a dose of 8-12 mg/kg every 2 weeks...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29138257/clinical-juvenile-arthritis-disease-activity-score-proves-to-be-a-useful-tool-in-treat-to-target-therapy-in-juvenile-idiopathic-arthritis
#12
Joost F Swart, E H Pieter van Dijkhuizen, Nico M Wulffraat, Sytze de Roock
OBJECTIVES: To assess if the Juvenile Arthritis Disease Activity Score (JADAS71) could be used to correctly identify patients with juvenile idiopathic arthritis (JIA) in need of antitumour necrosis factor therapy (anti-TNF) therapy 3 and 6 months after start of methotrexate (MTX). METHODS: Monocentric retrospective cohort study from 2011 to 2015 analysing all patients with oligoarticular JIA (OJIA) (n=39) and polyarticular course JIA (PJIA) (n=74) first starting MTX...
November 14, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29134239/temporomandibular-joint-atlas-for-detection-and-grading-of-juvenile-idiopathic-arthritis-involvement-by-magnetic-resonance-imaging
#13
Christian J Kellenberger, Thitiporn Junhasavasdikul, Mirkamal Tolend, Andrea S Doria
Contrast-enhanced magnetic resonance imaging (MRI) is considered the diagnostic standard for identifying involvement of the temporomandibular joint by juvenile idiopathic arthritis. Early or active arthritis is shown as bone marrow oedema, joint effusion, synovial thickening and increased joint enhancement. Subsequent joint damage includes characteristic deformity of the mandibular condyle, bone erosion, disk abnormalities and short mandibular ramus due to impaired growth. In this pictorial essay, we illustrate normal MRI findings and growth-related changes of the temporomandibular joint in children...
November 13, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29132381/patients-with-juvenile-idiopathic-arthritis-in-clinical-remission-with-positive-power-doppler-signal-in-joint-ultrasonography-have-an-increased-rate-of-clinical-flare-a-prospective-study
#14
Vanessa Bugni Miotto E Silva, Sônia de Aguiar Vilela Mitraud, Rita Nely Vilar Furtado, Jamil Natour, Claudio Arnaldo Len, Maria Teresa de Sande E Lemos Ramos Ascensão Terreri
BACKGROUND: Ultrasonography (US) studies carried out on joints of juvenile idiopathic arthritis (JIA) patients in clinical remission demonstrate the presence of subclinical synovitis. The significance of subclinical synovitis and the positive power Doppler (PD) signal on US in JIA in clinical remission is not well understood. The objectives of this study were to assess whether the changes detected by US in patients with JIA in clinical remission can predict disease flare and to evaluate factors associated with flare and joint damage over 30 months of follow-up...
November 13, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29131689/do-pedometers-with-or-without-education-on-exercise-increase-functional-walking-capacity-and-physical-activity-level-in-adolescents-with-juvenile-idiopathic-arthritis
#15
Jill Blitz, Sara M Stern, Katherine Marzan
To evaluate the impact of pedometer use on the physical activity (PA) and functional walking capacity (FWC) of adolescents with juvenile idiopathic arthritis (JIA) and lower extremity (LE) involvement. Twenty-seven adolescents, aged 11-19 years with JIA and LE involvement, participated in the three-phase pedometer study that introduced the use of a pedometer and an education seminar at 6 weeks. Measurements were taken at the baseline first visit and at weeks 6, 12, and 20. The primary outcome measure was the 6-minute walk test (6MWT)...
November 13, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29120582/role-of-ptpn22-1858-c-t-polymorphisms-in-juvenile-idiopathic-arthritis-in-egyptian-patients
#16
Yasser A Soliman, Nashwa I Hashaad, Sherin M Emam, Rehab R Mohamed
Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. The study included 60 children with JIA and 40 age and sex matched healthy children as controls. Patients and control groups were subjected to PTPN gene polymorphism analysis. Our findings indicated a significant difference in PTPN22 polymorphism between JIA patients and the control group (P = 0...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29116003/protocols-on-classification-monitoring-and-therapy-in-children-s-rheumatology-pro-kind-results-of-the-working-group-polyarticular-juvenile-idiopathic-arthritis
#17
REVIEW
Gerd Horneff, Ariane Klein, Gerd Ganser, Michaela Sailer-Höck, Annette Günther, Ivan Foeldvari, Frank Weller-Heinemann
OBJECTIVE: Several effective pharmacologic treatment options for polyarticual juvenile idiopathic arthritis (JIA) have emerged but initial treatment is heterogeneous in Germany. Therefore, the German Society of Pediatric Rheumatolgy has established a commission to develop consensus "Protocols on classification, monitoring and therapy in children's rheumatology (PRO-KIND)" to harmonize diagnostic and treatment approaches for new-onset JIA in Germany. METHODS: A set of definitions for in- and exclusion, diagnostic workup, parameters for the evaluation of disease activity criteria, therapeutic options, medication dosing, monitoring recommendations, targets, definitions of a therapy failure and four therapeutic algorithms developed by a working group were agreed by web based survey to which all members of the GKJR have been invited...
November 7, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29106714/pharmacokinetics-immunogenicity-and-efficacy-of-etanercept-in-pediatric-patients-with-moderate-to-severe-plaque-psoriasis
#18
Richard G Langley, Sree Kasichayanula, Mona Trivedi, Girish A Aras, Arunan Kaliyaperumal, Theresa Yuraszeck, John Gibbs, Megan Gibbs, Greg Kricorian, Amy S Paller
Etanercept has been recently approved in the United States for the treatment of moderate to severe plaque psoriasis in patients aged 4-17 years. The objective of this study was to characterize etanercept pharmacokinetics, immunogenicity, and efficacy in pediatric patients. Data from a phase 3 study and open-label extension study were analyzed. Etanercept serum concentrations in pediatric patients receiving etanercept 0.8 mg/kg (maximum, 50 mg) weekly were compared with adult psoriasis patients and pediatric patients with juvenile idiopathic arthritis (JIA) who received etanercept 0...
November 6, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29103180/safety-of-weekly-adalimumab-in-the-treatment-of-juvenile-idiopathic-arthritis-and-pediatric-chronic-uveitis
#19
Colleen K Correll, Danielle R Bullock, Rachel M Cafferty, Richard K Vehe
Weekly adalimumab dosing is used to treat juvenile idiopathic arthritis (JIA), uveitis, and other pediatric rheumatic diseases, but the safety of such dosing has not previously been studied. A retrospective chart review was conducted to assess the safety of weekly adalimumab. Demographic and clinical data were collected. Basic descriptive analysis was performed to assess for adverse events from weekly adalimumab. Sixty-nine patients at the University of Minnesota or Gillette Children's Hospital were identified as treated with weekly adalimumab...
November 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29101579/clinical-outcome-and-long-term-remission-in-jia
#20
REVIEW
Mia Glerup, T Herlin, M Twilt
PURPOSE OF REVIEW: This review assesses the long-term remission and predictors of clinical outcome in patients with juvenile idiopathic arthritis (JIA). A comprehensive literature search was performed including articles published between January 1, 2004 and February 28, 2017. Studies, with a minimum follow-up of 24 months, were selected independently by two reviewers based on in- and exclusion criteria. The objective outcome was inactive disease/clinical remission as defined by the Wallace criteria at last follow-up...
November 4, 2017: Current Rheumatology Reports
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