Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Ai Tien Nguyen, Antoine Rousseau, Bahram Bodaghi, Linda Rossi-Semerano, Caroline Galeotti, Elodie Da Cunha, Laura Eid, Marc Labetoulle, Emmanuel Barreau, Cherif Titah, Adélaïde Toutée, Isabelle Koné-Paut, Perrine Dusser, Charlotte Borocco
INTRODUCTION: Paediatric granulomatous uveitis (PGU) is rare. In addition, lack of awareness often leads to delayed diagnosis and poor visual outcome. Identifying the underlying cause and deciding how best to treat each patient is challenging. OBJECTIVES: To evaluate the demographics, aetiologies, complications, treatments, and visual prognosis of paediatric non-infectious granulomatous uveitis. METHODS: Retrospective chart review of non-infectious PGU occurring in children before the age of 16 years recruited from the Paediatric Rheumatology Unit, Bicêtre Hospital, France, from 2001 to 2023...
May 6, 2024: Rheumatology
#2
COMPARATIVE STUDY
Baoquan Wang, Yushan Zhang, Zhenbiao Zhao, Juan Ping, Liming Zhou, Yining Wang, Yongzhou Zhang
BACKGROUND: The goal of this study was to estimate the relative efficacy and safety of different biological agents (infliximab, canakinumab, baricitinib, anakinra, adalimumab, tofacitinib, tocilizumab, and rilonacept) compared with placebo for systemic juvenile idiopathic arthritis (JIA) patients, through a network meta-analysis. METHODS: Pubmed, Embase, and Cochrane Library were searched from database inception to July 2023 for randomized controlled trials comparing different biological agents (infliximab, canakinumab, baricitinib, anakinra, adalimumab, tofacitinib, tocilizumab, and rilonacept) or placebo directly or indirectly in JIA...
May 3, 2024: Medicine (Baltimore)
#3
JOURNAL ARTICLE
Laura Scagnellato, Giacomo Cozzi, Ilaria Prosepe, Mariagrazia Lorenzin, Andrea Doria, Giorgia Martini, Francesco Zulian, Roberta Ramonda
INTRODUCTION: Our aim was to describe a monocentric cohort of young adult patients with juvenile idiopathic arthritis (JIA), assessing the risk of relapse after transition to adult care. METHODS: We conducted a retrospective study and collected clinical, serological, and demographic data of young adult patients (18-30 years old) referred to the Transition Clinic of a single Italian centre between January 2020 and March 2023. Patients with systemic-onset JIA were excluded...
2024: PloS One
#4
Maha Abdalla Yahia Elhassan, Roua Mohammedali Hussain Idres, Baraa Mohamed Salaheldin Mohamed Elhassan, Naema Siddiq Banaga Siddiq, Rayan Abdelwahab Osman Mohammed, Mohammed Mahmmoud Fadelallah Eljack, Ghassan E Mustafa, Lina Hemmeda, Khabab Abbasher Hussien Mohamed Ahmed
INTRODUCTION AND IMPORTANCE: Macrophage activation syndrome (MAS) is a severe form of hemophagocytic lymphohistiocytosis that is frequently associated with either a flare-up of rheumatologic diseases, or infection and is characterized by intermittent fever, organomegaly, and multisystem dysfunction. Early diagnosis and treatment are crucial for outcome improvement. CASE PRESENTATION: The authors present a 9-year-old male with systemic onset juvenile idiopathic arthritis who presented with fever, vomiting, and nose bleeding, as well as being jaundiced, and having hepatomegaly and ascites...
May 2024: Annals of Medicine and Surgery
#5
JOURNAL ARTICLE
Victor A Verpalen, Francesca A Ververs, Martijn Slieker, Roos Nuboer, Joost F Swart, Cornelis K van der Ent, Zina Fejzic, Jos J M Westenberg, Tim Leiner, Heynric B Grotenhuis, Henk S Schipper
BACKGROUND: The recent Cardiovascular Disease in Adolescents with Chronic Disease (CDACD) study showed enhanced aortic stiffness and wall thickness in adolescents with various chronic disorders. Enhanced aortic stiffness can increase left ventricular (LV) afterload and trigger a cascade of adverse arterioventricular interaction. Here, we investigate the relation between aortic changes and LV function in the CDACD study participants. METHODS: This cross-sectional study included 114 adolescents 12-18 years old with cystic fibrosis (CF, n = 24), corrected coarctation of the aorta (CoA, n = 25), juvenile idiopathic arthritis (JIA, n = 20), obesity (n = 20), and healthy controls (n = 25)...
June 2024: IJC Heart & Vasculature
#6
MULTICENTER STUDY
Kyoko Saito, Avinash Gabbeta, Evan Mulvihill, Lina Al-Jaberi, Timothy Beukelman, James D Lewis, Carlos D Rose, Brian L Strom, Daniel B Horton
PURPOSE: To facilitate claims-based research on populations with juvenile idiopathic arthritis (JIA), we sought to validate an algorithm of new medication use as a proxy for worsening JIA disease activity. METHODS: Using electronic health record data from three pediatric centers, we defined new JIA medication use as (re)initiation of disease-modifying antirheumatic drugs or glucocorticoids (oral or intra-articular). Data were collected from 201 randomly selected subjects with (101) or without (100) new medication use...
May 2024: Pharmacoepidemiology and Drug Safety
#7
JOURNAL ARTICLE
Seher Sener, Emil Aliyev, Ezgi Deniz Batu, Zeynep Balik, Yagmur Bayindir, Veysel Cam, Ozge Basaran, Yelda Bilginer, Seza Ozen
OBJECTIVE: Our study was designed to investigate the reasons for starting the conventional disease-modifying anti-rheumatic drugs (DMARDs) and the variables that impact the response to DMARD treatment in oligoarticular juvenile idiopathic arthritis (JIA) patients. METHODS: Oligoarticular JIA patients (n = 187) were categorized into two groups: Group A consisted of patients who achieved remission with DMARD, and Group B comprised those who did not respond to DMARD therapy...
April 29, 2024: Clinical Rheumatology
#8
JOURNAL ARTICLE
Luis Fang, Dalgys Martínez, Catherine Meza-Torres, Ana Moreno-Woo, Nicole Pereira-Sanandres, Alex Domínguez-Vargas, Gloria Garavito, Eduardo Egea
OBJECTIVE: To evaluate the IgE reactivity of sera in patients suffering from type 1 diabetes (T1D), lupus nephritis (LN) and juvenile idiopathic arthritis (JIA) against a molecule constructed from T epitopes of A. lumbricoides allergens. METHODS: We designed and expressed a synthetic multi-epítope protein named MP1 from A. lumbricoides and house dust mites allergens. By indirect ELISA, we evaluated IgE-reactivity to MP1 and to the whole-body extract of Ascaris lumbricoides in 45 sera from Colombian Caribbean patients with lupus nephritis (LN; n=25), type 1 diabetes (T1D; n=10) and Juvenil idiopathic arthritis (JIA; n=10)...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#9
JOURNAL ARTICLE
Silvia Rosina, Ana I Rebollo-Gimenez, Letizia Tarantola, Angela Pistorio, Yulia Vyzhga, Yasser El Miedany, Hala M Lotfy, Hend Abu-Shady, Mervat Eissa, Naglaa S Osman, Waleed Hassan, Marwa Y Mahgoub, Nermeen A Fouad, Doaa M Mosa, Yasmin Adel, Sheren E M Mohamed, Ahmed R Radwan, Mohamed H Abu-Zaid, Samar A A Tabra, Radwa H Shalaby, Samah I Nasef, Raju Khubchandani, Archana Khan, Naziya P Maldar, Seza Ozen, Yagmur Bayindir, Motasem Alsuweiti, Raed Alzyoud, Hiba Almaaitah, Soamarat Vilaiyuk, Butsabong Lerkvaleekul, Ekaterina Alexeeva, Tatyana Dvoryakovskaya, Ivan Kriulin, Claudia Bracaglia, Manuela Pardeo, Fabrizio De Benedetti, Francesco Licciardi, Davide Montin, Francesca Robasto, Francesca Minoia, Giovanni Filocamo, Martina Rossano, Gabriele Simonini, Edoardo Marrani, Sarah Abu-Rumeleih, Mikhail M Kostik, Konstantin E Belozerov, Priyankar Pal, Jigna N Bathia, María M Katsicas, Giselle Villarreal, Achille Marino, Stefania Costi, Flavio Sztajnbok, Rodrigo M Silva, Maria C Maggio, Dalia H El-Ghoneimy, Rasha El Owaidy, Adele Civino, Federico Diomeda, Sulaiman M Al-Mayouf, Fuad Al-Sofyani, Zane Dāvidsone, Elisa Patrone, Claudia Saad-Magalhães, Alessandro Consolaro, Angelo Ravelli
OBJECTIVE: To develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis (sJIA), based on subjective disease state assessment by the treating pediatric rheumatologist. METHODS: The cutoffs definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries...
April 29, 2024: Arthritis & Rheumatology
#10
JOURNAL ARTICLE
Tao Zeng, Jian-Zhong Ye, Hui Qin, Qian-Qian Xu
BACKGROUND: Various non-steroidal anti-inflammatory drugs (NSAIDs) have been used for juvenile idiopathic arthritis (JIA). However, the optimal method for JIA has not yet been developed. AIM: To perform a systematic review and network meta-analysis to determine the optimal instructions. METHODS: We searched for randomized controlled trials (RCTs) from PubMed, EMBASE, Google Scholar, CNKI, and Wanfang without restriction for publication date or language at August, 2023...
April 26, 2024: World Journal of Clinical Cases
#11
JOURNAL ARTICLE
Bagavathy Shanmugam Karthikeyan, Tuulia Hyötyläinen, Tannaz Ghaffarzadegan, Eric Triplett, Matej Orešič, Johnny Ludvigsson
BACKGROUND: Prenatal exposure to environmental contaminants is a significant health concern because it has the potential to interfere with host metabolism, leading to adverse health effects in early childhood and later in life. Growing evidence suggests that genetic and environmental factors, as well as their interactions, play a significant role in the development of autoimmune diseases. OBJECTIVE: In this study, we hypothesized that prenatal exposure to environmental contaminants impacts cord serum metabolome and contributes to the development of autoimmune diseases...
April 27, 2024: Journal of Exposure Science & Environmental Epidemiology
#12
Niloofar Shashaani, Mehrnoush Hasas Yeganeh, Reza Sinaei, Shima Salehi, Reza Shiari
BACKGROUND: Mixed Connective Tissue Disease (MCTD) is a rare condition in children, characterized by a high titer of anti-ribonucleoprotein-U1 (anti-U1 RNP) antibodies, often presenting with overlapping features of two or more rheumatologic disorders, including juvenile idiopathic arthritis (JIA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), and juvenile dermatomyositis/polymyositis (JDM/PM). CASE PRESENTATION: We report the case of an 8-year-old girl with a history of fever, hair loss, lower extremities edema, weakness, oral aphthous ulcers, and a high titer of anti-U1 RNP antibodies, which is consistent with the diagnosis of MCTD...
April 25, 2024: Current Rheumatology Reviews
#13
JOURNAL ARTICLE
Ruy Pires de Oliveira-Sobrinho, Simone Appenzeller, Ianne Pessoa Holanda, Júlia Lôndero Heleno, Josep Jorente, On Behalf Of The Rare Genomes Project Consortium, Társis Paiva Vieira, Carlos Eduardo Steiner
Juvenile idiopathic arthritis is a heterogeneous group of diseases characterized by arthritis with poorly known causes, including monogenic disorders and multifactorial etiology. 22q11.2 proximal deletion syndrome is a multisystemic disease with over 180 manifestations already described. In this report, the authors describe a patient presenting with a short stature, neurodevelopmental delay, and dysmorphisms, who had an episode of polyarticular arthritis at the age of three years and eight months, resulting in severe joint limitations, and was later diagnosed with 22q11...
April 19, 2024: Genes
#14
JOURNAL ARTICLE
Lillemor Berntson, Andreas Elfving, Alice Gabrielsson Samuelsson, Anders Öman, Fariborz Mobarrez
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most prevalent rheumatic disease in children, and the inflammatory process is widely studied, primarily characterized by its impact on joint health. Emerging evidence suggests that JIA may also affect the central nervous system (CNS). This study investigates the potential CNS involvement in JIA by analyzing the presence of astrocyte-derived extracellular vesicles (EVs) and the S100B protein in plasma, both of which are indicative of astrocyte activity and blood-brain barrier (BBB) integrity...
April 26, 2024: Pediatric Rheumatology Online Journal
#15
JOURNAL ARTICLE
Özlem Akgün, Beyza Eliuz Tipici, Işık Gülcan Kahraman, Vafa Guliyeva, Fatma Gül Demirkan, Melike Zeynep Tuğrul Aksakal, Nuray Aktay Ayaz
OBJECTIVE: Proper nutrition is a significant contributor to growth achievement in patients with juvenile idiopathic arthritis (JIA). In this study, the aim was to analyze the growth parameters and nutritional status of children with JIA and then compare them with their healthy peers. METHODS: A cross-sectional study was conducted with 54 patients with JIA and the same number of healthy peers. Growth parameter z-scores and nutrient distributions were analyzed and compared with a control group and among disease subgroups...
March 30, 2024: Nutrition
#16
JOURNAL ARTICLE
Patrick Brossard, Christian Laveille
INTRODUCTION: Emapalumab is a fully human monoclonal antibody that targets free and receptor-bound interferon-gamma (IFNγ), neutralizing its biological activity. IFNγ levels differ by orders of magnitude between patients with primary hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS; a form of secondary HLH) in systemic juvenile idiopathic arthritis (sJIA). Therefore, this study aimed to develop a population pharmacokinetic model for emapalumab across a patient population with a wide range of total (free and emapalumab-bound) IFNγ levels using observations from patients with primary HLH or MAS in sJIA in clinical trials...
April 25, 2024: Rheumatology and Therapy
#17
JOURNAL ARTICLE
Nikhil C Gowda, Rudrarpan Chatterjee, Anu Balakrishnan, Able Lawrence, Amita Aggarwal
Juvenile Idiopathic Arthritis (JIA) causes caregiver burden on families with children affected with it. Our study aimed to explore this multifaceted burden in the Indian context. In this cross-sectional study, we administered the Hindi translated CAREGIVER questionnaire to adult caregivers in the families of JIA patients ≤ 18 years. The responses to the 28 items were used to calculate the burden scores in various dimensions. The relationship of the global burden scores with demographic and socioeconomic factors were analysed...
April 25, 2024: Clinical Rheumatology
#18
COMMENT
Ana T A Sachetto, Nigel Mackman
No abstract text is available yet for this article.
2024: Frontiers in Immunology
#19
JOURNAL ARTICLE
Racheal Githumbi, Susan Kuhn, Carla Osiowy, Jacqueline Day, Jennifer C C deBruyn, Marvin J Fritzler, Nicole A Johnson, Otto Vanderkooi, Heinrike Schmeling
This pilot randomized controlled trial assessed the immunogenicity of paediatric versus adult Hepatitis A vaccine doses in immunosuppressed adolescents (12-15 years) with Juvenile Idiopathic Arthritis and Crohn's Disease. The study aimed to assess if a single, higher dose provides better immunogenicity, particularly beneficial before travel.
April 23, 2024: Journal of Travel Medicine
#20
JOURNAL ARTICLE
Elnaz Panah, Erin Garfield, Zisansha Zahirsha, Aaron Muhlbauer, Eden Lake, Jodi Speiser
Blau syndrome is a rare familial autoinflammatory disorder characterized by the triad of granulomatous dermatitis, polyarthritis, and uveitis. Blau syndrome exhibits an autosomal dominant inheritance pattern and can be caused by a gain-of-function mutation in nucleotide-binding oligomerization domain 2 (NOD2), a member of the NOD-like receptor family of pattern recognition receptors. Mutations in NOD2 cause upregulation of inflammatory cytokines and resultant autoinflammation. Because of the rarity of this condition and early onset of symptoms, Blau syndrome may be misdiagnosed as juvenile idiopathic arthritis...
April 23, 2024: American Journal of Dermatopathology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
