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Non-Hodgkin's Lymphoma

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https://www.readbyqxmd.com/read/29907599/aggressive-b-cell-lymphomas-in-patients-with-myelofibrosis-receiving-jak1-2-inhibitor-therapy
#1
Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gregor Hoermann, Jean-Jacques Kiladjian, Thomas Kolbe, Christoph Kornauth, Maria-Theresa Krauth, Robert Kralovics, Leonhard Muellauer, Mathias Mueller, Michaela Prchal-Murphy, Eva Maria Putz, Emmanuel Raffoux, Ana-Iris Schiefer, Klaus Schmetterer, Christine Schneckenleithner, Ingrid Simonitsch-Klupp, Cathrin Skrabs, Wolfgang R Sperr, Philipp Bernhard Staber, Birgit Strobl, Peter Valent, Ulrich Jaeger, Heinz Gisslinger, Veronika Sexl
Inhibition of Janus-kinase 1/2 (JAK1/2) is a mainstay to treat myeloproliferative neoplasms (MPN). Sporadic observations reported the co-incidence of B-cell non-Hodgkin lymphomas during treatment of MPN with JAK1/2 inhibitors. We assessed 626 MPN patients including 69 with myelofibrosis receiving JAK1/2 inhibitors for lymphoma development. B-cell lymphomas evolved in 4/69 patients (5.8%) upon JAK1/2 inhibition compared to 2/557 (0.36%) with conventional treatment (16-fold increased risk). A similar 15-fold increase was observed in an independent cohort of 929 MPN patients...
June 14, 2018: Blood
https://www.readbyqxmd.com/read/29907126/nf-%C3%AE%C2%BAb-signaling-and-its-relevance-to-the-treatment-of-mantle-cell-lymphoma
#2
REVIEW
Swathi Balaji, Makhdum Ahmed, Elizabeth Lorence, Fangfang Yan, Krystle Nomie, Michael Wang
Mantle cell lymphoma is an aggressive subtype of non-Hodgkin B cell lymphoma that is characterized by a poor prognosis determined by Ki67 and Mantle Cell International Prognostic Index scores, but it is becoming increasingly treatable. The majority of patients, especially if young, achieve a progression-free survival of at least 5 years. Mantle cell lymphoma can initially be treated with an anti-CD20 antibody in combination with a chemotherapy backbone, such as VR-CAP (the anti-CD20 monoclonal antibody rituximab administered with cyclophosphamide, doxorubicin, and prednisone) or R-CHOP (the anti-CD20 monoclonal antibody rituximab administered with cyclophosphamide, doxorubicin, vincristine, and prednisone)...
June 15, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29905579/a-case-of-alk-anaplastic-large-cell-lymphoma-with-aberrant-myeloperoxidase-expression-and-initial-cutaneous-presentation
#3
Alejandro A Gru, Patrick J Voorhess
Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease...
November 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29904021/overcoming-resistance-of-human-non-hodgkin-s-lymphoma-to-cd19-car-ctl-therapy-by-celecoxib-and-histone-deacetylase-inhibitors
#4
Antoni Xavier Torres-Collado, Ali R Jazirehi
Patients with B-cell non-Hodgkin’s lymphoma (B-NHL) who fail to respond to first-line treatment regimens or develop resistance, exhibit poor prognosis. This signifies the need to develop alternative treatment strategies. CD19-chimeric antigen receptor (CAR) T cell-redirected immunotherapy is an attractive and novel option, which has shown encouraging outcomes in phase I clinical trials of relapsed/refractory NHL. However, the underlying mechanisms of, and approaches to overcome, acquired anti-CD19CAR CD8⁺ T cells (CTL)-resistance in NHL remain elusive...
June 14, 2018: Cancers
https://www.readbyqxmd.com/read/29901588/clinical-analysis-of-215-consecutive-cases-with-fever-of-unknown-origin-a-cohort-study
#5
Yong-Zhi Zhai, Xin Chen, Xin Liu, Zhi-Qiang Zhang, Hong-Ju Xiao, Gang Liu
Fever of unknown origin (FUO) is a frequently observed phenomenon in clinical practice. The present study was aimed to investigate potential causes of FUO, thereby improving clinical diagnosis of this disorder.In this retrospective study, clinical data were collected from 215 patients who were diagnosed with FUO between January 2009 and December 2010, and an 18 to 36 months follow-up visit was also performed for these patients.Among these FUO cases, the most common causes of the disease were infectious diseases (IDs) (42...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901111/dihydrocelastrol-exerts-potent-antitumor-activity-in-mantle-cell-lymphoma-cells-via-dual-inhibition-of-mtorc1-and-mtorc2
#6
Yongsheng Xie, Bo Li, Wenxuan Bu, Lu Gao, Yong Zhang, Xiucai Lan, Jun Hou, Zhijian Xu, Shuaikang Chang, Dandan Yu, Bingqian Xie, Yingcong Wang, Houcai Wang, Yiwen Zhang, Xiaosong Wu, Weiliang Zhu, Jumei Shi
Mantle cell lymphoma (MCL) is a distinct and highly aggressive subtype of B-cell non-Hodgkin lymphoma. Dihydrocelastrol (DHCE) is a dihydro-analog of celastrol, which is isolated from the traditional Chinese medicinal plant Tripterygium wilfordii. The present study aimed to investigate the effects of DHCE treatment on MCL cells, and to determine the mechanism underlying its potent antitumor activity in vitro and in vivo using the Cell Counting kit-8 assay, clonogenic assay, apoptosis assay, cell cycle analysis, immunofluorescence staining, western blotting and tumor xenograft models...
June 12, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29898383/foxp3-positive-t-cell-lymphomas-in-non-htlv1-carriers-include-alk-negative-anaplastic-large-cell-lymphoma-expanding-the-spectrum-of-t-cell-lymphomas-with-regulatory-phenotype
#7
Cristiane R Ferreira, Shuchun Zhao, Malaya K Sahoo, Benjamin Pinsky, Jenna Weber, Luis A P C Lage, Juliana Pereira, Maria C N Zerbini, Yasodha Natkunam
Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56years with a male predominance. Sites of disease included lymph nodes (4), skin (2), subcutaneous tissue (1) and bone marrow (1). All cases showed monomorphic large cells, some with Hodgkin-like or anaplastic cells. All cases expressed pan T cell markers and lacked cytotoxic markers; one case showed diffuse PD1 staining...
June 10, 2018: Human Pathology
https://www.readbyqxmd.com/read/29898091/cardiovascular-risk-and-use-of-conicity-index-in-patients-submitted-to-autologous-hematopoietic-stem-cell-transplantation
#8
Suelyne Rodrigues de Morais, Ana Carolina Cavalcante Viana, Ana Filomena Camacho Santos Daltro, Priscila da Silva Mendonça
OBJECTIVE: To analyze the prevalence of overweight and the use of conicity index for cardiovascular risk assessment in individuals submitted to autologous hematopoietic stem cell transplantation. METHODS: The sample comprised 91 patients of both sexes, who underwent autologous hematopoietic stem cell transplantation from September 2008 to December 2013, aged 18 years or over. To determine the nutritional profile, we collected anthropometric data on weight, height, waist circumference upon hospital admission...
June 7, 2018: Einstein
https://www.readbyqxmd.com/read/29895931/a-phase-iv-randomized-multicenter-open-label-trial-comparing-efficacy-and-systemic-exposure-for-a-standard-weight-based-dose-versus-a-fixed-dose-of-plerixafor-in-combination-with-g-csf-in-patients-with-non-hodgkin-s-lymphoma-weighing-%C3%A2-70-kg
#9
John Kuruvilla, Cheng-Hwai Tzeng, Seok-Goo Cho, Seok Jin Kim, Jih-Luh Tang, Yaming Su, Jingyang Wu, Rita Vargo, Peter Cheverton
A randomized, multicenter, open-label study explored the effect of a fixed-dose (FD) of plerixafor versus the approved weight-based (WB) dose for the mobilization of hematopoietic stem cells (HSCs) in patients with non-Hodgkin's lymphoma and a body weight of ≤70 kg. After mobilization with granulocyte colony-stimulating factor (G-CSF) 10 μg/kg/day for 4 days, patients were randomized 1:1 to either plerixafor FD 20 mg (n = 30) or WB 0.24 mg/kg (n = 31) on the evening of Day 4. Co-primary endpoints were the proportion of patients achieving ≥5 × 106 CD34+ cells/kg in ≤4 days of apheresis, and total systemic exposure to plerixafor (area under the concentration-time curve from 0 to 10 h [AUC0-10 ])...
June 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29895668/preinfusion-polyfunctional-anti-cd19-chimeric-antigen-receptor-t-cells-associate-with-clinical-outcomes-in-nhl
#10
John Rossi, Patrick Paczkowski, Yueh-Wei Shen, Kevin Morse, Brianna Flynn, Alaina Kaiser, Colin Ng, Kyle Gallatin, Tom Cain, Rong Fan, Sean Mackay, James R Heath, Steven A Rosenberg, James N Kochenderfer, Jing Zhou, Adrian Bot
After treatment with chimeric antigen receptor (CAR) T cells, interleukin (IL)-15 elevation and CAR T-cell expansion are associated with non-Hodgkin lymphoma (NHL) outcomes. However, the association of preinfusion CAR product T-cell functionality with clinical outcomes has not been reported. A single-cell analysis of the preinfusion CD19 CAR product from patients with NHL demonstrated that CAR products contain polyfunctional T-cell subsets capable of deploying multiple immune programs represented by cytokines and chemokines including interferon-γ (IFN-γ), IL-17A, IL-8, and macrophage inflammatory protein 1-α...
June 12, 2018: Blood
https://www.readbyqxmd.com/read/29895666/management-of-aggressive-b-cell-nhls-in-the-aya-population-an-adult-versus-pediatric-perspective
#11
Kieron Dunleavy, Thomas G Gross
The adolescents and young adult (AYA) population represent a group where mature B-cell lymphomas constitute a significant proportion of the overall malignancies that occur. Among these are aggressive B-cell non-Hodgkin lymphomas (NHLs) which are predominantly diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma (PMBCL) and Burkitt lymphoma (BL). For the most part, there is remarkable divide in how pediatric/adolescent patients (under the age of 18 years) with lymphoma are treated versus their young adult counterparts and molecular data are lacking, especially in pediatric and AYA series...
June 12, 2018: Blood
https://www.readbyqxmd.com/read/29893646/head-and-neck-tumors-amide-proton-transfer-mri
#12
Benjamin King Hong Law, Ann D King, Qi-Yong Ai, Darren M C Poon, Weitian Chen, Kunwar S Bhatia, Anil T Ahuja, Brigette B Ma, David Ka-Wai Yeung, Frankie Kwok Fai Mo, Yi-Xiang Wang, Jing Yuan
Purpose To evaluate the utility of amide proton transfer (APT) imaging in the characterization of head and neck tumors. Materials and Methods This retrospective study of APT imaging included 117 patients with 70 nasopharyngeal undifferentiated carcinomas (NUCs), 26 squamous cell carcinomas (SCCs), eight non-Hodgkin lymphomas (NHLs), and 13 benign salivary gland tumors (BSGTs). Normal tissues were examined in 25 patients. The APT means of malignant tumors, normal tissues, and benign tumors were calculated and compared with the Student t test and analysis of variance...
June 12, 2018: Radiology
https://www.readbyqxmd.com/read/29892537/widely-disseminated-sporadic-burkitt-lymphoma-initially-presented-as-oral-manifestations-in-a-6-year-old-boy
#13
Bong-Hae Cho, Dong-Hoon Shin, Yun-Hoa Jung, Hae-Ryoun Park
Burkitt lymphoma, a subtype of non-Hodgkin's lymphoma, is an aggressive neoplasm with three variants that are endemic, sporadic, and immunodeficiency associated. We present an unusual case of sporadic Burkitt lymphoma in a 6-year-old boy who initially presented with hypermobile teeth and no other specific signs or symptoms. On dental radiography, the patient was found to have alveolar bone resorption adjacent to the maxillary first molars, with the appearance of floating teeth. In addition, magnetic resonance imaging (MRI) showed extensive soft tissue masses involving four quadrants of the jaws...
May 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29892149/a-preliminary-study-on-the-estimation-of-the-number-of-cancer-patients-eligible-for-hadron-therapy-in-iran-and-fars-province
#14
Mohammad Amin Hosseini, Mohammad Mohamadianpanah, Mohammad Zare-Bandeamiri, Mohammad Amin Mosleh-Shirazi
Hadron therapy (HT) with protons and carbon ions is an advanced radiotherapy technique. As the first report addressing this topic, the present study aimed to estimate the number of patients eligible for HT in Fars province and the whole of Iran. The data were collected through direct inspection of medical records of the patients treated at the Radiotherapy Department, Namazi Hospital, Shiraz, Iran in 2014. The patients who were treated with external-beam radiotherapy and declared to be a resident of Fars province were extracted from the medical records...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29888716/ocular-adnexal-lymphomas-an-eye-care-service-experience-in-turkey
#15
B Kiziltas, C Baskan, R Duman, M S Dal
Aim: This study aimed to evaluate the clinical and pathological features of ocular adnexal lymphoma (OAL) and the treatment results in an eye care service center in Turkey. Materials and Methods: The data sets of the patients diagnosed with OAL acquired between January 2008 and January 2016 were collected and analyzed. Results: Fifteen patients were included in our study. The mean age was 55.80 ± 17.85 years. The age range was 7-85 years...
June 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29887343/incidence-of-cancer-other-than-gastric-cancer-in-pernicious-anaemia-a-systematic-review-with-meta-analysis
#16
REVIEW
Edith Lahner, Marina Capasso, Marilia Carabotti, Bruno Annibale
BACKGROUND: Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers. AIM: To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC. METHODS: Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017)...
May 24, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29884850/high-dose-therapy-with-beac-conditioning-compared-to-beam-conditioning-prior-to-autologous-stem-cell-transplantation-for-non-hodgkin-lymphoma-no-differences-in-toxicity-or-outcome-a-matched-control-study-of-the-ebmt-lymphoma-working-party
#17
Stephen Paul Robinson, Ariane Boumendil, Herve Finel, Peter Dreger, Anna Sureda, Olivier Hermine, Silvia Montoto
A recent shortage of melphalan has prompted the use of alternatives to BEAM (BCNU, Etoposide, Cytarabine, Melphalan) conditioning for autologous stem cell transplantion (ASCT). The BEAC (BCNU, Etoposide, Cytarabine, Cyclophosphamide) regimen has been employed as a conditioning regimen in lymphoma patients. However, there have been recent concerns about the toxicity of BEAC. We conducted a retrospective analysis of the EBMT database comparing the outcome of patients conditioned using BEAC with a matched cohort of patients conditioned with BEAM...
June 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29883922/multiple-primary-tumors-colorectal-carcinoma-and-non-hodgkin-s-lymphoma
#18
Diana A Pantoja Pachajoa, Marco Antonio Bruno, Fernando A Alvarez, Germán Viscido, Facundo Mandojana, Alejandro Doniquian
INTRODUCTION: Colorectal cancer (CRC) is the third most commonly diagnosed cancer, whereas lymphoma is the sixth leading cause of cancer death, 90% of which corresponds to non-Hodgkin's lymphoma (NHL). The association of these two primary tumors, a solid tumor with an hematological malignancy, is very uncommon. PRESENTATION OF CASE: We report the case of a 47-year-old man who presented with abdominal pain, a right upper quadrant mass and 12 kg of weight loss in 9 months...
May 30, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29883920/dyspnoea-thoracic-pain-and-fever-in-a-young-caucasian-female-a-case-report
#19
Alessandro Giuseppe Fois, Rocco Trisolini, Giorgio Carlo Ginesu, Elisabetta Zinellu, Silvia Negri, Alessandra Cancellieri, Alessandra Garau, Pietro Pirina
INTRODUCTION: The diagnostic approach to patients with mediastinal pathology is not always simple and an improper diagnostic work-up can lead to significant diagnosis delay. PRESENTATION OF CASE: We report on the case of a young woman who was admitted to the Emergency Department complaining of thoracic pain, dyspnoea, fever and productive cough. The physical examination showed a painful swelling over the sternum's upper left margin, which had become evident 4 months earlier...
May 31, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29881715/an-update-from-the-pediatric-proton-consortium-registry
#20
Clayton B Hess, Daniel J Indelicato, Arnold C Paulino, William F Hartsell, Christine E Hill-Kayser, Stephanie M Perkins, Anita Mahajan, Nadia N Laack, Ralph P Ermoian, Andrew L Chang, Suzanne L Wolden, Victor S Mangona, Young Kwok, John C Breneman, John P Perentesis, Sara L Gallotto, Elizabeth A Weyman, Benjamin V M Bajaj, Miranda P Lawell, Beow Y Yeap, Torunn I Yock
Background/objectives: The Pediatric Proton Consortium Registry (PPCR) was established to expedite proton outcomes research in the pediatric population requiring radiotherapy. Here, we introduce the PPCR as a resource to the oncology community and provide an overview of the data available for further study and collaboration. Design/methods: A multi-institutional registry of integrated clinical, dosimetric, radiographic, and patient-reported data for patients undergoing proton radiation therapy was conceived in May 2010...
2018: Frontiers in Oncology
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