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https://www.readbyqxmd.com/read/28551486/qualitative-agreement-and-diagnostic-performance-of-arterial-spin-labelling-mri-and-fdg-pet-ct-in-suspected-early-stage-dementia-comparison-of-arterial-spin-labelling-mri-and-fdg-pet-ct-in-suspected-dementia
#1
Kathleen Weyts, Meike Vernooij, Rebecca Steketee, Roelf Valkema, Marion Smits
18FDG PET-CT is useful for early and differential diagnosis of dementia. ASL-MRI seems an attractive alternative. Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ=0.85-0.86, p<0.05). Intermodality regional agreement was variable, moderate (κ=0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement...
May 19, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28551401/imaging-workup-of-suspected-classical-paraneoplastic-neurological-syndromes-a-systematic-review-and-retrospective-analysis-of-18-f-fdg-pet-ct
#2
Benedikt Sundermann, Jens-Burchard Schröder, Tobias Warnecke, Walter Heindel, Michael Schäfers, Matthias Weckesser, Boris Buerke
RATIONALE AND OBJECTIVES: This study aimed to assess the clinical efficacy of positron emission tomography (PET) or combined PET-computed tomography (CT) with (18)F-fluorodeoxyglucose (FDG) for whole-body cancer screening in patients with suspected paraneoplastic neurological syndromes (PNS). The following main research questions were addressed: What is the percentage of positive findings to be expected in whole-body FDG-PET-CT in adult patients with PNS? How many false positives can be expected as assessed by clinical and histopathological workup? Are there patients who present with a tumor despite initially negative findings? MATERIALS AND METHODS: This is a systematic review of the literature and retrospective analysis of FDG-PET-CT and clinical follow-up data from 45 consecutive patients (age: 56...
May 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28551398/regional-variation-in-skeletal-muscle-and-adipose-tissue-fdg-uptake-using-pet-ct-and-their-relation-to-bmi
#3
Marcus D Goncalves, Judith Green-McKenzie, Abass Alavi, Drew A Torigian
RATIONALE AND OBJECTIVES: Skeletal muscle metabolism is a primary contributor to whole-body energy expenditure. Currently, methods to measure changes in skeletal muscle metabolism in vivo are limited. Our objectives were to characterize the regional variation in skeletal muscle and adipose tissue (AT) FDG uptake as a surrogate for glycolytic metabolism using (18)F-2-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in healthy men and to correlate these findings to body mass index (BMI)...
May 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28550668/-the-relationship-between-18-f-fdg-pet-ct-metabolic-parameters-and-clinicopathological-features-of-breast-cancer
#4
B Tang, Y Zhang, J Zhou, Y Xu, T R Li, C Y Ding
Objective: To investigate the relationship between metabolic parameters of primary lesion and clinicopathological features of patients with breast cancer. Methods: Clinical data of 78 patients with breast cancer undergone (18)F-FDG PET/CT before surgery was retrospectively analyzed. SUVmax, SUVmean and metabolic tumor volume (MTV) of primary lesions were measured by horizontal, sagittal and coronal position volume section with a threshold of 40% SUVmax. TLG was calculated and the highest SUVmax among metastatic lymph nodes was measured...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28550639/philadelphia-chromosome-positive-acute-myeloid-leukemia-with-masses-and-osteolytic-lesions-finding-of-18f-fdg-pet-ct
#5
Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng
Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lytic lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lytic bone lesions...
May 27, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28550488/the-value-of-preoperative-positron-emission-tomography-computed-tomography-in-node-negative-endometrial-cancer-on-magnetic-resonance-imaging
#6
Jeong-Yeol Park, Jong Jin Lee, Hyuck Jae Choi, In Hye Song, Chang Ohk Sung, Hye Ok Kim, Sun-Young Chae, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: The aim of this study was to investigate the value of [18F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in predicting lymph node status in node-negative endometrial cancer on preoperative magnetic resonance imaging (MRI). METHODS: Patients with endometrial cancer who underwent both preoperative MRI and FDG-PET/CT followed by hysterectomy and lymphadenectomy were initially included. We then enrolled patients with MRI-defined node-negative disease (lymph nodes <1 cm in the short-axis diameter, or no visible lymph node)...
May 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28549964/a-strange-collection-after-surgery-for-an-aneurysm-of-the-popliteal-artery
#7
Gian Franco Veraldi, Luca Mezzetto, Roberta La Mendola, Paolo Criscenti, Marco Macrì, Albino Eccher
The popliteal fossa is the site of several diseases that may be similar in the clinical setting but very different in aetiology, treatment and prognosis. The contemporary presentation of more than one of these conditions is a rare though potentially fatal combination that may lead to a delay in the diagnosis and therapeutic approach. In this report we describe the case of a patient that presented at our Vascular Department for persistent pain and severe swelling of the right popliteal fossa eight months after the surgical treatment of a symptomatic popliteal aneurysm by mean of a dacron prosthetic graft...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549959/pet-scan-and-duplex-ultrasound-for-the-detection-of-arterial-complications-of-bacterial-endocarditis
#8
Carine Boulon, Noëlle Bernard, Fabrice Bonnet, Joël Constans
18F-FDG-PET may be useful to diagnose complications of endocarditis in difficult cases. We report the case of a young patient who had endocarditis and a painful leg. FDG PET/CT showed hypermetabolism in the leg and duplex ultrasound suggested an inflammatory aneurysm at the site of the hypermetabolism. The combination of FDG-PET/CT and duplex ultrasound is useful to diagnose mycotic aneurysm in the setting of bacterial endocarditis.
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549570/pet-mri-of-the-breast
#9
Donna M Plecha, Peter Faulhaber
The future clinical use of the combination of positron emission tomography (PET) with 2-Fluoro[F-18]-2-Deoxy-d-Glucose (FDG)and MRI is still unclear. If a patient requires a PET and breast DCE-MRI for staging purposes, both scans can be done in the same visit. In the breast, DCE-MRI is better at lesion detection (sensitivity), margin evaluation, and has a higher specificity than CT. The potential for multiparametric qualitative and quantitative imaging is also an advantage of PET/MRI which provides opportunity to improve tumor characterization and may ultimately lead to outcome prediction...
May 10, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28547176/metabolic-volume-performs-better-than-suvmax-in-the-detection-of-left-ventricular-assist-device-driveline-infection
#10
Nemanja Avramovic, Angelo Maria Dell'Aquila, Matthias Weckesser, Danka Milankovic, Alexis Vrachimis, Jürgen R Sindermann, Christian Wenning
PURPOSE: A continuous-flow left ventricular assist device (LVAD) is a new and highly promising therapy in supporting end-stage heart failure patients, either bridging them to heart transplantation or as a destination therapy. Infection is one of the major complications associated with LVAD implants. (18)F-FDG PET/CT has already been shown to be useful in the detection of LVAD infection. The goal of this study was to compare the diagnostic accuracy of different PET analysis techniques (visual grading versus SUVmax and metabolic volume)...
May 25, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28547129/quantitative-analysis-of-dynamic-18-f-fdg-pet-ct-for-measurement-of-lung-inflammation
#11
Christopher Coello, Marie Fisk, Divya Mohan, Frederick J Wilson, Andrew P Brown, Michael I Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S Murphy, Joseph Cheriyan, Roger N Gunn
BACKGROUND: An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) has been proposed as a promising imaging biomarker to assess this inflammation. We sought to introduce a fully quantitative analysis method and compare this with previously published studies based on the Patlak approach using a dataset comprising (18)F-FDG PET scans from COPD subjects with elevated circulating inflammatory markers (fibrinogen) and matched healthy volunteers (HV)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28546336/the-value-of-18-f-fdg-pet-ct-in-diagnosis-and-during-follow-up-in-273-patients-with-chronic-q-fever
#12
Ilse Kouijzer, Linda Kampschreur, Peter Wever, Corneline Hoekstra, Marjo van Kasteren, Monique de Jager-Leclercq, Marrigje Nabuurs-Franssen, Marjolijn Wegdam-Blans, Heidi Ammerlaan, Jacqueline Buijs, Lioe-Fee de Geus-Oei, Wim Oyen, Chantal Bleeker-Rovers
In 1-5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) in chronic Q fever at diagnosis and during follow-up. Methods: All Dutch adult patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015 when at least one (18)F-FDG-PET/CT was performed...
May 25, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28546332/establishing-177-lu-psma-617-radioligand-therapy-in-a-syngeneic-model-of-murine-prostate-cancer
#13
Wolfgang P Fendler, Andreea D Stuparu, Susan Evans-Axelsson, Katharina Lückerath, Liu Wei, Woosuk Kim, Soumya Poddar, Jonathan Said, Caius G Radu, Matthias Eiber, Johannes Czernin, Roger Slavik, Ken Herrmann
Clinical (177)Lu-PSMA-617 radioligand therapy (RLT) is applied in advanced stage prostate cancer. However, to the best of our knowledge murine models to study the biological effects of various activity levels have not been established. AIM: To optimize specific and total activity for (177)Lu-PSMA-617 RLT in a syngeneic model of murine prostate cancer. Methods: 0.1x106 murine reconstituted, oncogene-driven prostate cancer cells (RM1), transduced to express human prostate-specific membrane antigen (PSMA), were injected into the left flank of C57Bl6 immunocompetent mice...
May 25, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28546331/evaluation-of-dual-time-point-imaging-18-f-fdg-pet-ct-for-lymph-node-staging-in-vulvar-cancer
#14
Angela Collarino, Giorgia Garganese, Renato A Valdés Olmos, Antonella Stefanelli, Germano Perotti, Paoletta Mirk, Simona M Fragomeni, Francesco P Ieria, Giovanni Scambia, Alessandro Giordano, Vittoria Rufini
This study aimed to assess the value of dual time point (DTP) (18)F-FDG-PET/CT in the prediction of lymph node (LN) status in patients with invasive vulvar cancer (VC) scheduled for inguinofemoral lymph node dissection (IFLD). Methods: From April 2013 to July 2015, all consecutive patients with VC scheduled for IFLD were prospectively enrolled. All patients underwent a preoperative whole-body (18)F-FDG-PET/CT scan at 1-hour (standard exam) and an additional scan from T11 to the groins at 3-hour (delayed exam) after (18)F-FDG injection...
May 25, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28545563/additional-value-of-18-f-fdg-pet-ct-response-evaluation-in-axillary-nodes-during-neoadjuvant-therapy-for-triple-negative-and-her2-positive-breast-cancer
#15
Mette S van Ramshorst, Suzana C Teixeira, Bas B Koolen, Kenneth E Pengel, Kenneth G Gilhuijs, Jelle Wesseling, Sjoerd Rodenhuis, Renato A Valdés Olmos, Emiel J Rutgers, Wouter V Vogel, Gabe S Sonke, Marie-Jeanne T Vrancken Peeters
BACKGROUND: (18)F-FDG PET/CT can monitor metabolic activity in early breast cancer during neoadjuvant systemic therapy (NST), but it is unknown if the metabolic breast and axillary response differ. We evaluated the correlation between metabolic breast and axillary response at various time points during NST. Furthermore, we analysed if the combined metabolic response improves pathologic complete response (pCR) prediction compared to using the metabolic breast response alone. METHODS: (18)F-FDG PET/CT was performed at baseline (PET1), 2-3 weeks (PET2), and 6-8 weeks (PET3) of NST in patients with triple-negative (TN) and HER2-positive node-positive breast cancer...
May 25, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28545366/role-of-positron-emission-tomography-for-central-nervous-system-involvement-in-systemic-autoimmune-diseases-status-and-perspectives
#16
Daniele Mauro, Gaetano Barbagallo, Salvatore D'Angelo, Sannino Pasqualina, Saverio Naty, Caterina Bruno, Ignazio Olivieri, Rosa Daniela Grembiale, Francesco Ursini
In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography (PET). The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography (CT) or magnetic resonance imaging(MRI) in order to improve spatial resolution. Early preclinical studies suggested that 18F-FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28543682/residual-thymic-tissue-and-lymph-node-involvement-by-acute-myeloid-leukaemia-presenting-as-mediastinal-strongly-18-fdg-pet-positive-masses
#17
Georg Maschmeyer, Ingo Brink, Doris Jähne, Renate Arnold, Olaf Schega
We report on a multidisciplinary management of a 68-year old AML patient presenting with a PET-positive mediastinal tumour typical for lymph node metastasis. It was removed via minimally invasive thoracoscopic intervention and was identified as a thymus residual infiltrated by AML. Follow-up PET-CT scan after resection and remission induction chemotherapy was completely normal. To our knowledge, this is the first documented case report of AML presenting with PET-positive infiltrates of thymic and lymph node tissue along the aortic bow mimicking a second intrathoracic malignancy...
May 22, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28542311/18f-fdg-pet-ct-based-early-treatment-response-evaluation-of-nanoparticle-assisted-photothermal-cancer-therapy
#18
Kamilla Norregaard, Jesper T Jørgensen, Marina Simón, Fredrik Melander, Lotte K Kristensen, Pól M Bendix, Thomas L Andresen, Lene B Oddershede, Andreas Kjaer
Within the field of nanoparticle-assisted photothermal cancer therapy, focus has mostly been on developing novel heat-generating nanoparticles with the right optical and dimensional properties. Comparison and evaluation of their performance in tumor-bearing animals are commonly assessed by changes in tumor volume; however, this is usually a late-occurring event. This study implements 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography imaging to perform early evaluation of the treatment outcome of photothermal therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28541634/prognostic-value-of-metabolic-parameters-determined-by-preoperative-%C3%A2-%C3%A2-f-fdg-pet-ct-in-patients-with-uterine-carcinosarcoma
#19
Hyun Ju Lee, Jong Jin Lee, Jeong Yeol Park, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: To evaluate the prognostic value of metabolic parameters measured by preoperative ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT) in patients with uterine carcinosarcoma (UCS). METHODS: Data of 55 eligible patients with UCS who underwent preoperative ¹⁸F-FDG PET/CT and surgical staging were analyzed retrospectively. Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV₂.₅), and total lesion glycolysis (TLG₂...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28541123/new-exponential-functions-based-on-ct-density-to-estimate-the-percentage-of-liver-that-is-fat
#20
Georgia Keramida, A Michael Peters
OBJECTIVES: In FDG PET/CT, hepatic standardised uptake value (SUV) is reduced through 'signal dilution' by hepatic fat. Maximum SUV (SUVmax) is less affected than mean SUV (SUVmean), so SUVmax/SUVmean correlates with hepatic fat. SUV can be corrected for signal dilution using an equation relating CT density (CTD) to %fat. The objective was to exploit the relationship between SUV indices and CTD to assess the validity of two previously published equations (one linear, one sigmoid) for estimating %fat from CTD, and two new exponential equations...
May 25, 2017: British Journal of Radiology
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