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https://www.readbyqxmd.com/read/29449935/pleomorphic-liposarcoma-of-bone-a-rare-primary-malignant-bone-tumour
#1
G L Tiemeier, J M Brown, S E Pratap, C McCarthy, A Kastrenopoulou, K Bradley, S Wilson, Z Orosz, C L M H Gibbons, U Oppermann, N A Athanasou
Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29449445/evaluation-of-penalized-likelihood-estimation-reconstruction-on-a-digital-time-of-flight-pet-ct-scanner-for-18-f-fdg-whole-body-examinations
#2
Elin Lindström, Anders Sundin, Carlos Trampal, Lars Lindsjö, Ezgi Ilan, Torsten Danfors, Gunnar Antoni, Jens Sörensen, Mark Lubberink
Resolution and quantitative accuracy of positron emission tomography (PET) are highly influenced by the reconstruction method. Penalized likelihood estimation algorithms allow for fully convergent iterative reconstruction, generating a higher image contrast while limiting noise compared to ordered subsets expectation maximization (OSEM). In this study, block-sequential regularized expectation maximization (BSREM) was compared to time-of-flight OSEM (TOF-OSEM). Various strengths of noise penalization factor β were tested along with scan durations and transaxial field of views (FOVs) with the aim to evaluate the performance and clinical use of BSREM for 18 F-FDG-PET-computed tomography (CT), both in quantitative terms and in a qualitative visual evaluation...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29447210/functional-imaging-of-the-interaction-between-gut-microbiota-and-the-human-host-a-proof-of-concept-clinical-study-evaluating-novel-use-for-18f-fdg-pet-ct
#3
Ben Boursi, Thomas J Werner, Saeid Gholami, Sina Houshmand, Ronac Mamtani, James D Lewis, Gary D Wu, Abass Alavi, Yu-Xiao Yang
Recent data comparing germ-free to conventionally-raised mice demonstrated that energy homeostasis of colonocytes is dependent on gut microbiota through regulation of short chain fatty acids (SCFA) production and glucose utilization. We sought to evaluate 18F-FDG PET-CT as a novel technique for functional imaging of alterations in glucose metabolism as a result of the interaction between the gut microbiota and the human host. We conducted a prospective study in healthy humans that underwent 18F-FDG PET-CT and sampling of the gut microbiota before and after orally administered broad-spectrum antibiotics...
2018: PloS One
https://www.readbyqxmd.com/read/29446832/an-assessment-of-18-f-fdg-pet-ct-for-thoracic-screening-and-risk-stratification-of-pulmonary-nodules-in-multiple-endocrine-neoplasia-type-1
#4
Alvin So, Owen Pointon, Richard Hodgson, John Burgess
CONTEXT: Bronchopulmonary neuroendocrine tumours (bpNETs) and thymic carcinoid (ThC) are features of Multiple Endocrine Neoplasia Type 1 (MEN 1) and surveillance guidelines recommend periodic thoracic imaging. The optimal thoracic imaging modality and screening frequency remains uncertain as does the prognosis of small lung nodules when identified. OBJECTIVES: To evaluate fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) for identification and prognostic assessment of thoracic lesions in MEN 1...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29445601/predictors-of-unexpected-nodal-upstaging-in-patients-with-ct1-3n0-non-small-cell-lung-cancer-nsclc-submitted-to-thoracoscopic-lobectomy
#5
Giuseppe Marulli, Enrico Verderi, Giovanni M Comacchio, Nicola Monaci, Giuseppe Natale, Samuele Nicotra, Federico Rea
Background: In the last decades, the use of video-assisted thoracoscopic surgery (VATS) lobectomy for the treatment of early stage non-small cell lung cancer is continuously growing. This is mainly due to the development of more advanced surgical devices, to the rising incidence of peripheral lung tumors and is also favored by the increased reliability of preoperative staging techniques. Despite this progress, postoperative unexpected nodal upstaging is still a relevant issue. Aim of this study is to identify possible predictors of unexpected nodal upstaging in patients affected by cT1-3N0 NSCLC submitted to VATS lobectomy...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29443753/intense-18f-fdg-activity-in-aortoiliac-bypass-graft-mimicking-infection-a-case-report
#6
Minkyung Lee, Jeong Seon Ryu, Chang Hae Suh, In Young Hyun
RATIONALE: F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) has the potential to become an important imaging tool for the diagnosis of suspected aortoiliac bypass graft infection (AGI). PATIENT CONCERNS: A 76-year-old man presented with incidental findings of intense F-FDG activity in previous operation site of aortobiiliac bypass graft in the initial staging of small cell lung cancer (SCLC). DIAGNOSES: Based on F-FDG PET/CT examination, preliminary differential diagnosis was AGI...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443079/gene-regulation-and-targeted-therapy-in-gastric-cancer-peritoneal-metastasis-radiological-findings-from-dual-energy-ct-and-pet-ct
#7
Bowen Shi, Huimin Lin, Miao Zhang, Wei Lu, Ying Qu, Huan Zhang
Gastric cancer remains fourth in cancer incidence worldwide with a five-year survival of only 20%-30%. Peritoneal metastasis is the most frequent type of metastasis that accompanies unresectable gastric cancer and is a definitive determinant of prognosis. Preventing and controlling the development of peritoneal metastasis could play a role in helping to prolong the survival of gastric cancer patients. A non-invasive and efficient imaging technique will help us to identify the invasion and metastasis process of peritoneal metastasis and to monitor the changes in tumor nodules in response to treatments...
January 22, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442350/occult-phosphaturic-mesenchymal-tumor-of-femur-cortex-causing-oncogenic-osteomalacia-diagnostic-challenges-and-clinical-outcomes
#8
Deep Dutta, Raghuvansh Kumar Pandey, Rakhee Gogoi, Nagender Solanki, Renu Madan, Anupam Mondal, Shruti Dogra, Pradeep Thapa
BACKGROUND: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Investigations were significant for severe hypophosphatemia, severe phosphaturia, normal serum calcium, reduced 1,25-dihydroxy vitamin-D, elevated ALP, elevated intact parathyroid hormone (iPTH), and pseudo-fractures involving pelvis and bilateral femur...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442349/18f-fdg-avid-sclerosing-angiomatoid-nodular-transformation-sant-of-spleen-on-pet-ct-a-rare-mimicker-of-metastasis
#9
Punit Sharma
Sclerosing Angiomatoid Nodular Transformation (SANT) is a rare benign vascular tumor of spleen. It consists of multiple angiomatoid nodules surrounded by dense fibrous tissue that often coalesces centrally to form a scar, which is considered to be a characteristic feature. These are usually asymptomatic and incidentally detected on imaging for other underlying pathology. SANTs can be 18F-Fluorodeoxyglucose (18F-FDG) avid on positron emission tomography-computed tomography (PET-CT) and thus can lead to false positive finding in oncological patients...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29442347/f-18-fdg-pet-ct-in-pulmonary-artery-sarcoma-clinical-vignette
#10
Stjepan Hmelik, Margareta Dobrenić, Dražen Huić
Pulmonary artery sarcomas (PAS's) are extremely rare malignant tumors that arise from the endothelial lining of the pulmonary arteries. On CT scans PAS's appear as intraluminal filling defects in the pulmonary arteries, mimicking pulmonary embolism (PE). Due to the similarities in radiographic features as well as in clinical presentation, PAS's are usually misdiagnosed as pulmonary embolism. Since PASs are F-18 FDG avid, F-18 FDG PET/CT scan is a useful imaging tool for differentiating between these two conditions, as shown in this case report...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29441371/gastrointestinal-stromal-tumor-of-the-esophagus-current-issues-of-diagnosis-surgery-and-drug-therapy
#11
REVIEW
Jun Hihara, Hidenori Mukaida, Naoki Hirabayashi
Gastrointestinal stromal tumors (GISTs) often arise in the stomach and small intestine, while esophageal GISTs are rare. Due to their rarity, clinicopathological data on esophageal GISTs are extremely limited, and this results in a lack of clear recommendations concerning optimal surgical management for esophageal GISTs. It is difficult to distinguish esophageal GIST from leiomyoma, the most frequent esophageal mesenchymal tumor, prior to resection, because the two types of tumors appear similar on computed tomography (CT), endoscopic ultrasound (EUS), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29439011/measurement-of-brown-adipose-tissue-activity-using-microwave-radiometry-mrad-and-fdg-pet-ct
#12
John Crandall, Joo Hyun O, Prateek Gajwani, Jeffrey P Leal, Daniel D Mawhinney, Fred Sterzer, Richard L Wahl
Purpose: The aim of this study was to evaluate a microwave radiometer system in the non-invasive assessment of activated and non-activated brown adipose tissue (BAT). Materials and Methods: In this prospective study, microwave radiometry (MRAD) and fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with computed tomography (CT) were performed on nineteen participants who underwent a cold intervention to activate BAT. The cold intervention involved the participant intermittently placing their feet on a cold block of ice while sitting in a cool room...
February 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29438845/-brain-over-body-a-study-on-the-willful-regulation-of-autonomic-function-during-cold-exposure
#13
Otto Muzik, Kaice T Reilly, Vaibhav A Diwadkar
The defense of body temperature against environmental thermal challenges is a core objective of homeostatic regulation governed by the autonomic nervous system. Autonomous mechanisms of thermoregulation are only weakly affected by top-down modulation, allowing only transient tolerance for extreme cold. There is however, anecdotal evidence of a unique set of individuals known for extreme cold tolerance. Here we present a case study of a 57-year old Dutch national, Wim Hof, the so-called "Iceman", with the ability to withstand frequent prolonged periods of extreme cold exposure based on the practice of a self-developed technique involving a combination of forced breathing, cold exposure and meditation (collectively referred to as the Wim Hof Method, henceforth "WHM")...
February 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29437755/a-diagnostic-cohort-study-on-the-accuracy-of-18-fluorodeoxyglucose-18-fdg-positron-emission-tomography-pet-ct-for-evaluation-of-malignancy-in-anterior-mediastinal-lesions-the-decimal-study
#14
Chiara Proli, Paulo De Sousa, Simon Jordan, Vladimir Anikin, Anand Devaraj, Susannah M Love, Michael Shackcloth, Nikolaos Kostoulas, Kostas Papagiannopoulos, Yama Haqzad, Mahmoud Loubani, Francesco Sellitri, Felice Granato, Alexander Bush, Adrian Marchbank, Swetha Iyer, Marco Scarci, Eric Lim
OBJECTIVES: The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass SETTING: DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites...
February 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29435154/efficacy-of-granulocyte-macrophage-colony-stimulating-factor-combined-with-metronomic-paclitaxel-in-the-treatment-of-lewis-lung-carcinoma-transplanted-in-mice
#15
Nengping Zhu, Rongsheng Qin, Qin Zhang, Shaozhi Fu, Shanshan Liu, Yue Chen, Juan Fan, Yunwei Han
Metronomic chemotherapy in combination with immunotherapy is an attractive approach in cancer therapy. The purpose of the present study was to investigate the anti-tumor effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with metronomic paclitaxel (MET PTX) on Lewis lung carcinoma transplanted in mice. In the present study, tumor-bearing mice survival time and tumor growth were monitored. The day after the end of the treatment, white blood cells were counted, and the number and maturation of dendritic cell were determined by flow cytometry...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434881/18f-fluorodeoxyglucose-positron-emission-computed-tomography-for-monitoring-tumor-response-in-esophageal-carcinoma-treated-with-concurrent-chemoradiotherapy
#16
Peiliang Zhang, Zengyun Li, Dongqing Wang, Fuling Ma, Ran Zhang, Wanhua Liang, Mingping Sun, Zheng Fu, Xiaorong Sun
The aim of the present study was to explore the value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in monitoring the early tumor response of esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). A total of 48 patients with pathologically proven ESCC were retrospectively analyzed. All patients underwent two serial 18F-FDG PET scans at baseline (pre-CRT) and 40 Gy/4 weeks of starting radiation therapy (inter-CRT). All patients received intensity-modulated radiotherapy (with a total radiation dose of 59...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434164/nivolumab-induces-sustained-liver-injury-in-a-patient-with-malignant-melanoma-a-case-report
#17
Tokuhiro Matsubara, Tsutomu Nishida, Yu Higaki, Ryo Tomita, Hiromi Shimakoshi, Akiyoshi Shimoda, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Dai Nakamatsu, Kaori Mukai, Masashi Yamamoto, Koji Fukui, Shiro Adachi, Masami Inada
A 42-year-old man was diagnosed with cStage IIIb malignant melanoma and underwent resection. After interferon-beta therapy, 18-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) showed multiple lung metastases, and he received nivolumab (2 mg/kg) every 3 weeks, resulting in a total of 17 cycles. After treatment, 18F-FDG PET/CT showed a significant decrease in the size of the metastases, but he had a Grade 4 ALT elevation. Liver histology revealed drug-induced liver damage. Therefore, we performed steroid half-pulse therapy followed by oral methylprednisolone, but his ALT level did not completely recover to the normal range even after five months...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432345/18f-fdg-pet-ct-findings-in-a-patient-with-igg4-related-sclerosing-mesenteritis
#18
Zhanli Fu, Guoqian Chen, Meng Liu, Ziao Li, Qian Li
A large mass in the abdomen was revealed by ultrasonography on a 68-year-old woman presenting with abdominal pain and weight loss. To exclude the malignancy, an F-FDG PET/CT was performed, which showed a solitary soft tissue mass with heterogeneous F-FDG avidity at the root of small bowel mesentery. Because of the elevation of inflammatory markers and serum IgG4 level, IgG4-related sclerosing mesenteritis was suspected, which was proved by the subsequent biopsy. The mass gradually shrunk and ultimately disappeared in 6 months after a low-dose steroid therapy...
February 9, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29432344/metaplastic-squamous-cell-carcinoma-of-breast-demonstrated-on-18f-fdg-pet-ct
#19
Hongyan Yin, Yan Xiu, Rongkui Luo, Hongwei Zhang, Hongcheng Shi
A 32-year-old woman presented with 3 months' history of rapid enlargement of the left breast and superficial ulceration. Staging F-FDG PET/CT performed after admission demonstrated a hypermetabolic mass in the left breast, with smaller hypermetabolic areas in the left axillary and internal mammary lymph nodes, as well as in the sternum. Postoperatively, the mass was diagnosed as metaplastic squamous cell carcinoma of the breast.
February 9, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29432341/rare-case-of-intratracheal-metastasis-detected-on-68ga-prostate-specific-membrane-antigen-pet-ct-scan-in-a-case-of-thyroglobulin-elevated-negative-iodine-scan-syndrome
#20
Arun Sasikumar, Ajith Joy, M R A Pillai, Karuna Elza Oommen, R Jayakumar
A 64-year-old woman underwent completion thyroidectomy with upper tracheal ring resection and right-sided neck dissection for papillary carcinoma of the thyroid infiltrating the trachea and was given I radioiodine treatment. Three years later, she presented with hemoptysis. On evaluation, she had increased serum thyroglobulin and negative iodine scan (TENIS). F-FDG PET/CT scan did not identify any site of disease. One year later, Ga-PSMA scan done revealed a moderate focal tracer-avid intratracheal soft tissue; biopsy revealed it to be metastatic papillary carcinoma of the thyroid...
February 9, 2018: Clinical Nuclear Medicine
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