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https://www.readbyqxmd.com/read/29890193/opportunities-in-biotechnology
#1
Kevan M A Gartland, Jill S Gartland
Strategies for biotechnology must take account of opportunities for research, innovation and business growth. At a regional level, public-private collaborations provide potential for such growth and the creation of centres of excellence. By considering recent progress in areas such as genomics, healthcare diagnostics, synthetic biology, gene editing and bio-digital technologies, opportunities for smart, strategic and specialised investment are discussed. These opportunities often involve convergent or disruptive technologies, combining for example elements of pharma-science, molecular biology, bioinformatics and novel device development to enhance biotechnology and the life sciences...
June 8, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29885727/the-relation-between-patient-discomfort-and-uncompensated-forces-of-a-patient-support-device-for-breast-and-regional-lymph-node-radiotherapy
#2
Bert Boute, Liv Veldeman, Bruno Speleers, Annick Van Greveling, Tom Van Hoof, Joris Van de Velde, Tom Vercauteren, Wilfried De Neve, Jan Detand
Although many authors stated that a user-centred design approach in medical device development has added values, the most common research approach within healthcare is evidence-based medicine, which tend to focus on functional data rather than patient wellbeing and comfort. End user comfort is well addressed in literature for commercial products such as seats and hand tools but no data was found for medical devices. A commercial patient support device for breast radiotherapy was analysed and a relation was found between discomfort and uncompensated internal body forces...
October 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29874913/photoluminescence-and-photoconductivity-to-assess-maximum-open-circuit-voltage-and-carrier-transport-in-hybrid-perovskites-and-other-photovoltaic-materials
#3
Ian L Braly, Ryan J Stoddard, Adharsh Rajagopal, Alex K-Y Jen, Hugh W Hillhouse
Photovoltaic (PV) device development is much more expensive and time consuming than the development of the absorber layer alone. This perspective focuses on two methods that can be used to rapidly assess and develop PV absorber materials independent of device development. The absorber material properties of quasi-Fermi level splitting and carrier diffusion length under steady effective one-Sun illumination are indicators of a material's ability to achieve high VOC and JSC. These two material properties can be rapidly and simultaneously assessed with steady-state absolute intensity photoluminescence and photoconductivity measurements...
June 6, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29872335/sublingual-sufentanil-for-postoperative-pain-relief-first-clinical-experiences
#4
Fleur Meijer, Petra Cornelissen, Corina Sie, Michel Wagemans, Anja Mars, Tiny Hobma, Marieke Niesters, Albert Dahan, J Seppe Koopman, Monique Ah Steegers
Background: The sublingual sufentanil tablet system (SSTS) is a novel hand-held patient-controlled analgesia device developed for treatment of moderate-to-severe postoperative pain. Here we present the first results of its clinical use. Methods: Adult patients undergoing major surgery in five hospitals in the Netherlands received the SSTS for postoperative pain relief as part of multimodal pain management that further included paracetamol and a nonsteroidal anti-inflammatory drug (NSAID)...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29862507/a-pilot-study-of-a-novel-specs-for-chronic-dizziness
#5
C R Gordon, R Tamir, R Furas, C Klein, R Roth
OBJECTIVE: A pilot study to assess the efficacy and safety of a novel specs device developed to alleviate chronic dizziness using eyeglasses with referential marks fixed on the lenses. MATERIALS AND METHODS: Forty patients with stable symptoms of chronic dizziness for more than 3 months participated in a 4-week, double-blind, randomized treatment with Active-Specs or Sham-Specs. Efficacy was assessed using validated semiquantitative scales and questionnaires of vertigo, dizziness and anxiety...
June 3, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29848596/building-our-future-to-provide-the-most-optimal-peritoneal-access-through-surgeon-training-programs-and-medical-device-development
#6
John H Crabtree
No abstract text is available yet for this article.
May 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29847689/implantable-miniature-telescope-imt-for-vision-loss-due-to-end-stage-age-related-macular-degeneration
#7
REVIEW
Amisha Gupta, Jessica Lam, Peter Custis, Stephen Munz, Donald Fong, Marguerite Koster
BACKGROUND: Age-related macular degeneration (AMD) causes progressive and irreversible damage to the retina, resulting in loss of central vision. AMD is the third leading cause of irreversible visual impairment worldwide and the leading cause of blindness in industrialized countries. Since AMD is more common in older individuals, the number of affected individuals will increase significantly as the population ages. The implantable miniature telescope (IMT) is an ophthalmic device developed to improve vision in individuals who have lost vision due to AMD...
May 30, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29843456/carbon-nanotube-field-emitters-synthesized-on-metal-alloy-substrate-by-pecvd-for-customized-compact-field-emission-devices-to-be-used-in-x-ray-source-applications
#8
Sangjun Park, Amar Prasad Gupta, Seung Jun Yeo, Jaeik Jung, Sang Hyun Paik, Mallory Mativenga, Seung Hoon Kim, Ji Hoon Shin, Jeung Sun Ahn, Jehwang Ryu
In this study, a simple, efficient, and economical process is reported for the direct synthesis of carbon nanotube (CNT) field emitters on metal alloy. Given that CNT field emitters can be customized with ease for compact and cold field emission devices, they are promising replacements for thermionic emitters in widely accessible X-ray source electron guns. High performance CNT emitter samples were prepared in optimized plasma conditions through the plasma-enhanced chemical vapor deposition (PECVD) process and subsequently characterized by using a scanning electron microscope, tunneling electron microscope, and Raman spectroscopy...
May 29, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29803934/the-clinical-innovation-network-a-policy-for-promoting-development-of-drugs-and-medical-devices-in-japan
#9
Shunsuke Matsushita, Keisuke Tachibana, Masuo Kondoh
The continuous increase in the costs of developing new drugs and medical devices drives increases in medical expenses. Seventy to ninety percent of these costs are associated with clinical trials. Therefore, the development of cost-effective methods to perform clinical trials remains a challenge. One approach is to use patient registries, collections of data related to patients with a specific diagnosis, condition, or procedure. Patient registries are used in Denmark, Sweden, and the USA for the enrollment of patients into clinical trials, and to evaluate endpoints...
May 24, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29779498/retrieval-of-large-occlutech-figula-flex-septal-defect-occluders-using-a-commercially-available-bioptome-proof-of-concept
#10
Stanimir Georgiev, Daniel Tanase, Thomas Genz, Peter Ewert, Susanne Naumann, Robert Dalla Pozza, Andreas Eicken
OBJECTIVES: This study aimed to develop a method for retrieval of the new meshed nitinol atrial septal defect occluders - Ceraflex and Occlutech. BACKGROUND: The newly developed atrial septal defect occluders have potential benefits considering implantation, but concerns regarding their removal in case of embolisation have been raised. METHODS: Over 21 years, 1449 patients underwent interventional atrial septal defect occlusion in our institution...
May 21, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29751514/magnetoresistance-effect-and-the-applications-for-organic-spin-valves-using-molecular-spacers
#11
REVIEW
Xiannian Yao, Qingqing Duan, Junwei Tong, Yufang Chang, Lianqun Zhou, Gaowu Qin, Xianmin Zhang
Organic spin devices utilizing the properties of both spin and charge inherent in electrons have attracted extensive research interest in the field of future electronic device development. In the last decade, magnetoresistance effects, including giant magetoresistance and tunneling magnetoresistance, have been observed in organic spintronics. Significant progress has been made in understanding spin-dependent transport phenomena, such as spin injection or tunneling, manipulation, and detection in organic spintronics...
May 3, 2018: Materials
https://www.readbyqxmd.com/read/29732002/implantable-wireless-powered-light-emitting-diode-led-for-near-infrared-photoimmunotherapy-device-development-and-experimental-assessment-in-vitro-and-in-vivo
#12
Kohei Nakajima, Toshihiro Kimura, Hideo Takakura, Yasuo Yoshikawa, Atsushi Kameda, Takayuki Shindo, Kazuhide Sato, Hisataka Kobayashi, Mikako Ogawa
Purpose: The aim of this study was to develop and assess a novel implantable, wireless-powered, light-emitting diode (LED) for near-infrared photoimmunotherapy (NIR-PIT). NIR-PIT is a recently developed cancer therapy that uses NIR light and antibody-photosensitizer conjugates and is able to induce cancer-specific cell death. Due to limited light penetration depth it is currently unable to treat tumors in deep tissues. Use of implanted LED might potentially overcome this limitation. Results: The wireless LED system was able to emit NIR light up to a distance of 20 cm from the transmitter coil by using low magnetic fields as compliant with limits for use in humans...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29706898/injection-less-conductance-method-for-vascular-sizing
#13
Ali E Dabiri, Ghassan S Kassab
Lumen vessel sizing is important for optimization of interventional outcomes for treatment of vascular disease. The objective of this study is to develop an injection-less method to determine the lumen diameter, using multiple frequencies that eliminates the need for saline injections. We utilize the same electrical conductance devices developed for the two-injection method. A mathematical electrical model was devised to estimate the lumen area and diameter of the arteries. In vitro experiments were used to validate the method for various lumen diameters with both 5-5-5 (peripheral) and 2-2-2 (coronary) spacing conductance guidewires...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29702099/prostate-ablation-using-high-intensity-focused-ultrasound-the-potential-role-for-patient-preference-information-a-literature-review
#14
REVIEW
Olufemi Babalola, Joyce Ting-Hsuan Lee, Charles Viviano
PURPOSE: The Food and Drug Administration (FDA) recently allowed marketing of two HIFU devices for prostate tissue ablation indications after previous rejections for a prostate cancer indication due to insufficient data on clinical effectiveness or direct patient benefit. A review of the safety and effectiveness of HIFU and knowledge regarding patient preferences, such as tolerance for adverse events associated with HIFU ablation of tissue in men with prostate cancer, may inform decision-making for device developers and the FDA...
April 24, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29664645/mesoscopic-elastic-distortions-in-gaas-quantum-dot-heterostructures
#15
Anastasios Pateras, Joonkyu Park, Youngjun Ahn, Jack A Tilka, Martin V Holt, Christian Reichl, Werner Wegscheider, Timothy A Baart, Juan Pablo Dehollain, Uditendu Mukhopadhyay, Lieven M K Vandersypen, Paul G Evans
Quantum devices formed in high-electron-mobility semiconductor heterostructures provide a route through which quantum mechanical effects can be exploited on length scales accessible to lithography and integrated electronics. The electrostatic definition of quantum dots in semiconductor heterostructure devices intrinsically involves the lithographic fabrication of intricate patterns of metallic electrodes. The formation of metal/semiconductor interfaces, growth processes associated with polycrystalline metallic layers, and differential thermal expansion produce elastic distortion in the active areas of quantum devices...
May 9, 2018: Nano Letters
https://www.readbyqxmd.com/read/29663370/deformable-torso-phantoms-of-chinese-adults-for-personalized-anatomy-modelling
#16
Hongkai Wang, Xiaobang Sun, Tongning Wu, Congsheng Li, Zhonghua Chen, Meiying Liao, Mengci Li, Wen Yan, Hui Huang, Jia Yang, Ziyu Tan, Libo Hui, Yue Liu, Hang Pan, Yue Qu, Zhaofeng Chen, Liwen Tan, Lijuan Yu, Hongcheng Shi, Li Huo, Yanjun Zhang, Xin Tang, Shaoxiang Zhang, Changjian Liu
In recent years, there has been increasing demand for personalized anatomy modelling for medical and industrial applications, such as ergonomics device development, clinical radiological exposure simulation, biomechanics analysis, and 3D animation character design. In this study, we constructed deformable torso phantoms that can be deformed to match the personal anatomy of Chinese male and female adults. The phantoms were created based on a training set of 79 trunk computed tomography (CT) images (41 males and 38 females) from normal Chinese subjects...
July 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29651487/the-organic-2d-transition-metal-dichalcogenide-heterointerface
#17
REVIEW
Yu Li Huang, Yu Jie Zheng, Zhibo Song, Dongzhi Chi, Andrew T S Wee, Su Ying Quek
Since the first isolation of graphene, new classes of two-dimensional (2D) materials have offered fascinating platforms for fundamental science and technology explorations at the nanometer scale. In particular, 2D transition metal dichalcogenides (TMD) such as MoS2 and WSe2 have been intensely investigated due to their unique electronic and optical properties, including tunable optical bandgaps, direct-indirect bandgap crossover, strong spin-orbit coupling, etc., for next-generation flexible nanoelectronics and nanophotonics applications...
May 8, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29619894/analysis-of-laboratory-and-benchtop-performance-of-a-mealtime-insulin-delivery-system
#18
Eric Zijlstra
In the current issue of Journal of Diabetes Science and Technology, Dreon et al give a comprehensive overview of the technical performance of a wearable patch for bolus insulin delivery. The test results generated by the manufacturer of the bolus-patch provide the technical prerequisites for clinical application. As the device received FDA clearance already in 2010, positive results from the nonclinical performance testing were to be expected, but present nevertheless interesting insights into the device development...
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29608504/inter-atrial-shunting-a-novel-device-based-therapy-for-patients-with-heart-failure
#19
Brian Kw Yum, William H Frishman
Heart failure patients with either reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF) experience a high mortality rate. The most recent pharmacologic advance for treating patients with HFrEF has been with sacubitril/valsartan. Along with pharmaceutical research, there has been interest in device-based therapies as another treatment approach. One novel interventional device therapy that has shown promise in early tests and trials is the inter-atrial shunt device developed by Corvia Medical Inc...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29579404/analytical-chemistry-in-the-regulatory-science-of-medical-devices
#20
Yi Wang, Allan Guan, Samanthi Wickramasekara, K Scott Phillips
In the United States, regulatory science is the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of all Food and Drug Administration-regulated products. Good regulatory science facilitates consumer access to innovative medical devices that are safe and effective throughout the Total Product Life Cycle (TPLC). Because the need to measure things is fundamental to the regulatory science of medical devices, analytical chemistry plays an important role, contributing to medical device technology in two ways: It can be an integral part of an innovative medical device (e...
March 26, 2018: Annual Review of Analytical Chemistry
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