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https://www.readbyqxmd.com/read/29226723/pen-devices-for-self-injection-contrasting-measured-injection-force-with-users-perceived-ease-of-injection
#1
Andreas E Schneider, Jakob Lange
OBJECTIVES: Past research has emphasized injection force as a clinically highly relevant technical attribute of pen devices. However, little work has been conducted to relate these results to in-use studies. This article explores whether and how differences in pen injection force profiles influence users' self-reported perceived ease of injection and preferences. METHODS: Three different pen systems were subjected to measurements of injection force using an automated mechanical set-up followed by a simulated use study where users assessed perceived ease of injection...
December 9, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29222625/using-patient-feedback-to-optimize-the-design-of-a-certolizumab-pegol-electromechanical-self-injection-device-insights-from-human-factors-studies
#2
Barbara Domańska, Oliver Stumpp, Steven Poon, Serkan Oray, Irina Mountian, Clovis Pichon
INTRODUCTION: We incorporated patient feedback from human factors studies (HFS) in the patient-centric design and validation of ava®, an electromechanical device (e-Device) for self-injecting the anti-tumor necrosis factor certolizumab pegol (CZP). METHODS: Healthcare professionals, caregivers, healthy volunteers, and patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or Crohn's disease participated in 11 formative HFS to optimize the e-Device design through intended user feedback; nine studies involved simulated injections...
December 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29197602/continuous-flow-perfused-cadaver-model-for-endovascular-training-research-and-development
#3
Amrita Sarkar, Richa Kalsi, Joseph D Ayers, Charles B Drucker, Vaidehi Kaushal, William Sutton, Robert S Crawford
BACKGROUND: Endovascular simulation employing computer, animal, and static models are common and useful adjuncts for teaching endovascular procedures and developing novel, complex endovascular techniques. Unfortunately, these models lack realistic haptic feedback and thus do not faithfully replicate many of the technical challenges associated with clinical endovascular procedures (e.g., arterial calcification, rigidity, and stenosis). We sought to develop a realistic and reproducible perfused cadaver model for endovascular training, device development and research...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29183379/gait-performance-and-foot-pressure-distribution-during-wearable-robot-assisted-gait-in-elderly-adults
#4
Su-Hyun Lee, Hwang-Jae Lee, Won Hyuk Chang, Byung-Ok Choi, Jusuk Lee, Jeonghun Kim, Gyu-Ha Ryu, Yun-Hee Kim
BACKGROUND: A robotic exoskeleton device is an intelligent system designed to improve gait performance and quality of life for the wearer. Robotic technology has developed rapidly in recent years, and several robot-assisted gait devices were developed to enhance gait function and activities of daily living in elderly adults and patients with gait disorders. In this study, we investigated the effects of the Gait-enhancing Mechatronic System (GEMS), a new wearable robotic hip-assist device developed by Samsung Electronics Co, Ltd...
November 28, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29176639/enhancement-of-power-output-by-using-alginate-immobilized-algae-in-biophotovoltaic-devices
#5
Fong-Lee Ng, Siew-Moi Phang, Vengadesh Periasamy, Kamran Yunus, Adrian C Fisher
We report for the first time a photosynthetically active algae immobilized in alginate gel within a fuel cell design for generation of bioelectricity. The algal-alginate biofilm was utilized within a biophotovoltaics (BPV) device developed for direct bioelectricity generation from photosynthesis. A peak power output of 0.289 mWm-2 with an increase of 18% in power output compared to conventional suspension culture BPV device was observed. The increase in maximum power density was correlated to the maximum relative electron transport rate (rETRm)...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136879/development-and-evaluation-of-a-new-diffusive-gradients-in-thin-films-technique-for-measuring-organotin-compounds-in-coastal-sediment-pore-water
#6
Russell F Cole, Graham A Mills, Michelle S Hale, Ruth Parker, Thi Bolam, Peter R Teasdale, William W Bennett, Gary R Fones
Organotins present a toxicological risk to biota in the aquatic environment. Understanding the behaviour of these compounds in sediment is challenging, with sophisticated analytical techniques required for their measurement. We investigated the use of silica-bound sorbents for diffusive gradients in thin-films (DGT) adsorption gels to pre-concentrate five organotins (monobutlytin (MBT), dibutyltin (DBT), tributyltin (TBT), diphenyltin (DPhT), triphenyltin (TPhT)) found frequently in coastal sediment. C8 sorbent showed optimum performance in uptake and recovery of organotins for pH and ionic strength ranges typical of coastal waters...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29124558/development-of-a-simple-device-enabling-percutaneous-flow-regulation-for-a-small-vascular-graft-for-a-blalock-taussig-shunt-capable-of-flow-regulation-complete-translation-of-a-review-article-originally-published-in-pediatric-cardiology-and-cardiac-surgery
#7
Yoshikazu Motohashi, Ryo Shimada, Tomoyasu Sasaki, Takahiro Katsumata, Kazunori Dan, Yasuhiro Tsutsui, Shintaro Nemoto
OBJECTIVES: The Blalock-Taussig shunt (BTS) operation is a cornerstone as initial palliative surgery for congenital heart disease with severely reduced pulmonary blood flow (PBF). The ideal PBF provided by BTS is crucial for an uneventful postoperative course, since excess PBF results in acute distress of the systemic circulation and insufficient PBF requires another BTS surgery. Therefore, the goal of this study was to develop a simple device to control the shunt graft flow percutaneously using a constrictor balloon connected to a subcutaneous port...
November 9, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29101314/clinical-and-radiological-analysis-of-bryan-cervical-artificial-disc-replacement-for-skip-multi-segment-cervical-spondylosis-long-term-follow-up-results
#8
Zikun Shang, Yingze Zhang, Di Zhang, Wenyuan Ding, Yong Shen
BACKGROUND The aim of this study was to retrospectively analyze the clinical and radiological efficacy of Bryan cervical artificial disc replacement (ADR) for "skip" multi-segment cervical spondylosis (SCS). MATERIAL AND METHODS We enrolled 49 patients with SCS treated with either Bryan cervical ADR (18 cases) or ACDF (31 cases). Each case was evaluated preoperatively and at more than 48 months postoperatively in follow-up using the JOA, NDI, and VAS. Cervical sagittal curvature, total cervical ROM, and degree of middle segments of motion were also evaluated...
November 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29073776/distance-between-the-anterior-distal-tibial-edge-and-the-anterior-tibial-artery-in-distraction-and-nondistraction-during-anterior-ankle-arthroscopy-a-cadaveric-study
#9
Ichiro Tonogai, Fumio Hayashi, Yoshihiro Tsuruo, Koichi Sairyo
BACKGROUND: Anterior ankle arthroscopy is widely applied for various osteoarthropathies. However, distraction of the ankle may put the anterior tibial artery (ATA) at risk of injury during the procedure. The purpose of this study was to assess the difference in the distance between the anterior distal tibial edge and the ATA in distraction and nondistraction of the ankle with joint space expansion by saline injection into the joint. METHODS: Eight whole fresh-frozen cadaveric feet (mean age 78...
October 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29071193/recent-advances-in-biosensor-development-for-foodborne-virus-detection
#10
REVIEW
Suresh Neethirajan, Syed Rahin Ahmed, Rohit Chand, John Buozis, Éva Nagy
Outbreaks of foodborne diseases related to fresh produce have been increasing in North America and Europe. Viral foodborne pathogens are poorly understood, suffering from insufficient awareness and surveillance due to the limits on knowledge, availability, and costs of related technologies and devices. Current foodborne viruses are emphasized and newly emerging foodborne viruses are beginning to attract interest. To face current challenges regarding foodborne pathogens, a point-of-care (POC) concept has been introduced to food testing technology and device...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29068728/tissue-adhesive-for-vascular-access-devices-who-what-where-and-when
#11
Amanda Corley, Nicole Marsh, Amanda J Ullman, Claire M Rickard
Despite vascular access devices (VADs) being vital for patient care, device failure rates are unacceptably high with around 25% of central venous devices, and 30-40% of peripheral venous devices, developing complications that result in VAD failure. The use of tissue adhesive is a novel method of securing VADs and is gaining popularity, however the evidence base guiding its clinical use is still emerging. This article aims to review the types and properties of tissue adhesives, provide an overview of the existing evidence base, and discuss how tissue adhesives may be used in clinical practice...
October 26, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29059044/expanding-the-utilization-of-robotic-procedures-in-urologic-surgery
#12
REVIEW
Gilad Amiel, Tareq Aro, Michael Mullerad, Gilad E Amiel
Although the word "robot" was coined in 1921, only close to 70 years later were robotic devices developed to assist during surgery. Urology has always been at the forefront of endoscopic, minimally invasive, and robotic developments in medicine. Robotic prostatectomy signaled the emerging role of robotic surgery in urology, but since then it has been applied to every urologic laparoscopic procedure.
October 16, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/29041456/cylindrical-vector-resonant-modes-achieved-in-planar-photonic-crystal-cavities-with-enlarged-air-holes
#13
Kang Chang, Liang Fang, Chenyang Zhao, Jianlin Zhao, Xuetao Gan
We reveal a triangular-lattice planar photonic crystal supports Bloch modes with radially and azimuthally symmetric electric field distributions at the top band-edge of the first photonic band. Bifurcated from the corresponding Bloch modes, two cylindrical vector resonant modes are achieved by simply enlarging the central air-hole of the planar photonic crystal, which have high quality factors around 3,000 and small mode volume of (λ/n)(3). The far-field radiations of the two resonant modes present high-quality cylindrical vector beam profiles...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29037270/micron-scale-deformation-a-coupled-in-situ-study-of-strain-bursts-and-acoustic-emission
#14
Ádám István Hegyi, Péter Dusán Ispánovity, Michal Knapek, Dániel Tüzes, Kristián Máthis, František Chmelík, Zoltán Dankházi, Gábor Varga, István Groma
Plastic deformation of micron-scale crystalline materials differs considerably from bulk samples as it is characterized by stochastic strain bursts. To obtain a detailed picture of the intermittent deformation phenomena, numerous micron-sized specimens must be fabricated and tested. An improved focused ion beam fabrication method is proposed to prepare non-tapered micropillars with excellent control over their shape. Moreover, the fabrication time is less compared with other methods. The in situ compression device developed in our laboratory allows high-accuracy sample positioning and force/displacement measurements with high data sampling rates...
October 17, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29033104/progesterone-releasing-devices-for-cattle-estrus-induction-and-synchronization-device-optimization-to-anticipate-shorter-treatment-durations-and-new-device-developments
#15
W de Graaff, B Grimard
Synchronization programs using progesterone-releasing intravaginal devices that allow for fixed time artificial insemination are still finding increasing application in bovine reproduction. This practice is useful for rationalizing livestock management because an increased number of cows can be inseminated in one session without the need for estrus detection. Although much of the innovation related to the design and development of intravaginal devices for use in cattle took place in the previous century, progress in understanding the physiology of the bovine estrous cycle resulted in shorter treatment durations, a trend which is still continuing...
September 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/29031303/current-advances-and-challenges-in-microfluidic-free-flow-electrophoresis-a-critical-review
#16
REVIEW
Pedro Novo, Dirk Janasek
The research field on microfluidic free-flow electrophoresis has developed vast amounts of devices, methods, applications and raised new questions, often in analogy to conventional techniques from which it derives. Most efforts have been employed on device development and a myriad of architectures and fabrication techniques have been reported using simple proof-of-principle separations. As technological aspects reach a quite mature state, researchers' new challenges include the development of protocols for the separation of complex mixtures, as required in the fields of application...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#17
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28973987/creating-active-device-materials-for-nanoelectronics-using-block-copolymer-lithography
#18
Cian Cummins, Alan P Bell, Michael A Morris
The prolonged and aggressive nature of scaling to augment the performance of silicon integrated circuits (ICs) and the technical challenges and costs associated with this has led to the study of alternative materials that can use processing schemes analogous to semiconductor manufacturing. We examine the status of recent efforts to develop active device elements using nontraditional lithography in this article, with a specific focus on block copolymer (BCP) feature patterning. An elegant route is demonstrated using directed self-assembly (DSA) of BCPs for the fabrication of aligned tungsten trioxide (WO₃) nanowires towards nanoelectronic device application...
September 30, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28956820/raman-computational-and-experimental-studies-of-dopamine-detection
#19
John D Ciubuc, Kevin E Bennet, Chao Qiu, Matthew Alonzo, William G Durrer, Felicia S Manciu
A combined theoretical and experimental analysis of dopamine (DA) is presented in this work with the objective of achieving more accurate detection and monitoring of this neurotransmitter at very low concentrations, specific to physiological levels. Surface-enhanced Raman spectroscopy on silver nanoparticles was employed for recording DA concentrations as low as 10(-11) molar. Quantum chemical density functional calculations were carried out using Gaussian-09 analytical suite software. Relatively good agreement between the simulated and experimentally determined results indicates the presence of different DA molecular forms, such as uncharged DA(±), anionic DA(-), and dopaminequinone...
September 28, 2017: Biosensors
https://www.readbyqxmd.com/read/28941247/wear-testing-of-a-canine-hip-resurfacing-implant-that-uses-highly-cross-linked-polyethylene
#20
Kevin J Warburton, John B Everingham, Jillian L Helms, Andrew J Kazanovicz, Katherine A Hollar, Jeff D Brourman, Steven M Fox, Trevor J Lujan
Hip resurfacing offers advantages for young, active patients afflicted with hip osteoarthritis and may also be a beneficial treatment for adult canines. Conventional hip resurfacing uses metal-on-metal bearings to preserve bone stock, but it may be feasible to use metal-on-polyethylene bearings to reduce metal wear debris while still preserving bone. This study characterized the short-term wear behavior of a novel hip resurfacing implant for canines that uses a 1.5 mm thick liner of highly cross-linked polyethylene in the acetabular component...
September 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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