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"Device development"

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https://www.readbyqxmd.com/read/29448523/mimicking-the-synaptic-weights-and-human-forgetting-curve-using-hydrothermally-grown-nanostructured-cuo-memristor-device
#1
T D Dongale, P S Pawar, R S Tikke, N B Mullani, V B Patil, A M Teli, K V Khot, S V Mohite, A A Bagade, V S Kumbhar, K Y Rajpure, P N Bhosale, R K Kamat, P S Patil
In the present investigation, we have fabricated copper oxide (CuO) thin film memristor by employing a hydrothermal method for neuromorphic application. The X-ray diffraction pattern confirms the films are polycrystalline in nature with the monoclinic crystal structure. The developed devices show analog memory and synaptic property similar to biological neuron. The size dependent synaptic behavior is investigated for as-prepared and annealed CuO memristor. The results suggested that the magnitude of synaptic weights and resistive switching voltages are dependent on the thickness of the active layer...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29430214/angular-photodiode-array-based-device-to-detect-bacterial-pathogens-in-a-wound-model
#2
Robin E Sweeney, Jeong-Yeol Yoon
We have developed a device that is able to rapidly and specifically diagnose bacterial pathogens in a wound model based on Mie scatter spectra from a tissue surface. The Mie scatter spectra collected is defined as the intensity of Mie scatter over the angle of detection from a tissue surface. A 650 nm LED perpendicular to the surface illuminates a tissue sample (90°) and photodiodes positioned in 10° increments from 10° to 80° of backscatter act as the detectors to collect these Mie scatter spectra. Through principal component analysis of the Mie scatter spectra collected, we have shown significant differences between Mie scatter spectra of tissues with bacterial pathogens versus those without, as well as significant differences between each species of bacteria tested...
November 1, 2017: IEEE Sensors Journal
https://www.readbyqxmd.com/read/29426227/bacterially-driven-cadmium-sulfide-precipitation-on-porous-membranes-toward-platforms-for-photocatalytic-applications
#3
Katherine E Marusak, Julia R Krug, Yaying Feng, Yangxiaolu Cao, Lingchong You, Stefan Zauscher
The emerging field of biofabrication capitalizes on nature's ability to create materials with a wide range of well-defined physical and electronic properties. Particularly, there is a current push to utilize programmed, self-organization of living cells for material fabrication. However, much research is still necessary at the interface of synthetic biology and materials engineering to make biofabrication a viable technique to develop functional devices. Here, the authors exploit the ability of Escherichia coli to contribute to material fabrication by designing and optimizing growth platforms to direct inorganic nanoparticle (NP) synthesis, specifically cadmium sulfide (CdS) NPs, onto porous polycarbonate membranes...
February 9, 2018: Biointerphases
https://www.readbyqxmd.com/read/29422631/electrically-tunable-perfect-light-absorbers-as-color-filters-and-modulators
#4
Seyed Sadreddin Mirshafieyan, Don A Gregory
Methods for spectrally controlling light absorption in optoelectronic devices have attracted considerable attention in recent years. It is now well known that a Fabry-Perot nanocavity comprising thin semiconductor and metal films can be used to absorb light at selected wavelengths. The absorption wavelength is controlled by tailoring the thickness of the nanocavity and also by nanostructure patterning. However, the realization of dynamically tuning the absorption wavelength without changing the structural geometry remains a great challenge in optoelectronic device development...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420761/chinese-military-evaluation-of-a-portable-near-infrared-detector-of-traumatic-intracranial-hematomas
#5
Chun-Yang Liang, Yang Yang, Chun-Sen Shen, Hai-Jiang Wang, Nai-Ming Liu, Zhi-Wen Wang, Feng-Lei Zhu, Ru-Xiang Xu
Introduction: Secondary brain injury is the main cause of mortality from traumatic brain injury (TBI). One hallmark of TBI is intracranial hemorrhage, which occurs in 40-50% of severe TBI cases. Early identification of intracranial hematomas in TBI patients allows early surgical evacuation and can reduce the case fatality rate of TBI. As pre-hospital care is the weakest part of Chinese emergency care, there is an urgent need for a capability to detect brain hematomas early. In China, in addition to preventing injuries and diseases in military staff and in enhancing the military armed forces during war, military medicine participates in actions such as emergency public health crises, natural disasters, emerging conflicts, and anti-terrorist campaigns during peacetime...
February 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29414009/a-gold-standard-method-for-the-evaluation-of-antibody-based-materials-functionality-approach-to-forced-degradation-studies
#6
Gaëlle Coussot, Aurélie Le Postollec, Clément Faye, Michel Dobrijevic
The scope of this paper is to present a gold standard method to evaluate functional activity of antibody (Ab)-based materials during the different phases of their development, after their exposure to forced degradations or even during routine quality control. Ab-based materials play a central role in the development of diagnostic devices, for example, for screening or therapeutic target characterization, in formulation development, and in novel micro(nano)technology approaches to develop immunosensors useful for the analysis of trace substances in pharmaceutical and food industries, clinical and environmental fields...
January 23, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29389429/conceptualizing-treatment-of-uncomplicated-type-b-dissection-using-the-ideal-framework
#7
Grace J Wang, Philip P Goodney, Art Sedrakyan
OBJECTIVE: The objective of this study was to introduce a new framework, called IDEAL (idea, development, exploration, assessment, and long-term study), to guide physicians, investigators, and regulatory agencies through the life cycle of device development and procedural refinement. METHODS: This review describes the IDEAL framework and illustrates its application for treatment of uncomplicated type B dissection (uTBD) as an example of this process. RESULTS: Components of IDEAL are summarized and applied to devices used to treat uTBD...
February 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29377941/sex-differences-in-the-outcomes-of-stent-implantation-in-mini-swine-model
#8
Mie Kunio, Gee Wong, Peter M Markham, Elazer R Edelman
Sex-related differences have been noted in cardiovascular anatomy, pathophysiology, and treatment responses, yet we continued to drive evaluation of vascular device development in animal models without consideration of animal sex. We aimed to understand sex-related differences in the vascular responses to stent implantation by analyzing the pooled data of endovascular interventions in 164 Yucatan mini-swine (87 female, 77 male). Bare metal stents (BMS) or drug-eluting stents (DES) were implanted in 212 coronary arteries (63 single BMS implantation, 68 single DES implantation, 33 overlapped BMS implantation, and 48 overlapped DES implantation)...
2018: PloS One
https://www.readbyqxmd.com/read/29372641/enhanced-metal-insulator-transition-performance-in-scalable-vanadium-dioxide-thin-films-prepared-using-a-moisture-assisted-chemical-solution-approach
#9
Weizheng Liang, Min Gao, Chang Lu, Zhi Zhang, Cheuk Ho Chan, Lanjian Zhuge, Ji-Yan Dai, Hao Yang, Chonglin Chen, Bae Ho Park, Quanxi Jia, Yuan Lin
Vanadium dioxide (VO2) is a strong-correlated metal-oxide with a sharp metal-insulator transition (MIT) for broad device development. However, synthesizing epitaxial VO2 films with desired properties has been a challenge due to the difficulty in controlling the oxygen stoichiometry of VOx, where x can be in the range of 1< x <2.5 and V has multiple valence states. Herein, a unique moisture-assisted chemical solution approach has been developed to successfully manipulate the oxygen stoichiometry, to significantly broaden the growth window, and to significantly enhance the MIT performance of VO2 films...
January 26, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29371003/how-sensors-devices-and-biomarkers-can-transform-precision-medicine-perspectives-from-a-clinical-and-translational-science-institute
#10
Jill L Maron, Graham B Jones
PURPOSE: The ability of sophisticated sensors and medical devices to monitor critical biomarkers has the potential to greatly advance precision medicine initiatives. A stakeholder event was organized to develop working models for the evolution of the field. METHODS: A workshop devoted to the subject matter was held at the Tufts Clinical and Translational Science Institute involving clinicians, device developers, regulators, engineers, and scientists. FINDINGS: Several areas for collaborative development were identified and interested teams offered resources for development of research programs...
January 19, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29368505/cohpi-nanoflakes-for-enhanced-oxygen-evolution-reaction
#11
Jingjing Wang, Hua Chun Zeng
Electrochemical splitting of water to produce hydrogen and oxygen is an important process for many energy storage and conversion devices. Developing efficient, robust, low-cost, and earth-abundant electrocatalysts for the oxygen evolution reaction (OER) is therefore of great importance. Herein, we report a method to prepare two-dimensional cobalt hydrogen phosphate (CoHPi) through chemical conversion of α-Co(OH)2 precursor at room-temperature. The CoHPi nanoflakes contain HPO42- anions which have been demonstrated to serve as a proton acceptor in proton coupled electron transfer process (PCET) of OER...
January 25, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29362293/self-neutralizing-plga-magnesium-composites-as-novel-biomaterials-for-tissue-engineering
#12
Thomas O Xu, Hyun Sung Kim, Tyler Stahl, Syam Prasad Nukavarapu
Controlling acidic degradation of biodegradable polyesters remains a major challenge when used them as biomaterials in biomedical devices. This work presents a simple strategy of developing polyester composites with biodegradable magnesium metal or alloys. PLGA films with compositions of 1, 3, 5, and 10 wt% Mg were simply produced using the solvent-casting method, which resulted in composite films with near uniform Mg metal/alloy particle dispersion. Degradation study of the composite films showed that all compositions higher than 1 wt% Mg were able to extend the duration of degradation, and buffer acidic pH resulting from PLGA degradation...
January 24, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29331489/modulation-of-lower-extremity-joint-stiffness-work-and-power-at-different-walking-and-running-speeds
#13
Li Jin, Michael E Hahn
Locomotion task and speed changes affect dynamic joint function. Walking and running require different coordination patterns of lower extremity joint mechanics. These coordination differences can result in measurable changes in kinematic and kinetic patterns. When locomotion speed changes, the functional role and movement strategy of each joint is altered. A deeper understanding of joint level mechanics and functional interactions will benefit rehabilitation programs and assistive device development. In this study, joint stiffness, joint mechanical work and power were assessed, as they relate to dynamic function of joints during locomotion...
January 10, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29329885/innoscent-system-advancing-flavor-analysis-using-an-original-gas-chromatographic-analytical-device
#14
A Villière, S Le Roy, C Fillonneau, C Prost
Despite continuous advances in analytical and physiological knowledge, the comprehension of an aroma is still a challenge. Gas chromatography coupled to olfactometry (GC-O) is an efficient method to identify and estimate individual potential of odorants, but there is a gap between this individual characterization and the effective contribution of compounds in the mixture, which is due to complex chemical and perceptual interactions. Therefore, recombination and omission experiments are often performed to achieve an understanding of food aromas...
December 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29318451/bringing-the-national-security-agency-into-the-classroom-ethical-reflections-on-academia-intelligence-agency-partnerships
#15
Christopher Kampe, Gwendolynne Reid, Paul Jones, Colleen S, Sean S, Kathleen M Vogel
Academia-intelligence agency collaborations are on the rise for a variety of reasons. These can take many forms, one of which is in the classroom, using students to stand in for intelligence analysts. Classrooms, however, are ethically complex spaces, with students considered vulnerable populations, and become even more complex when layering multiple goals, activities, tools, and stakeholders over those traditionally present. This does not necessarily mean one must shy away from academia-intelligence agency partnerships in classrooms, but that these must be conducted carefully and reflexively...
January 9, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29299924/high-performance-colorimetric-carbon-monoxide-sensor-for-continuous-personal-exposure-monitoring
#16
Chenwen Lin, Xiaojun Xian, Xingcai Qin, Di Wang, Francis Tsow, Erica S Forzani, Nongjian Tao
Carbon monoxide (CO) is a highly poisonous gas, which can cause serious health risk. CO monitoring helps protect us from excessive exposure at home and in the workplace, and reduce occupation-related health risks for workers. Conventional electrochemical and metal oxide semiconductors (MOS) based CO sensors have been widely used, but the drawbacks such as poor selectivity and calibration burden also limit their applications, e.g. as wearable exposure monitors. Aiming at the reliable, miniaturized, and easy-to-use personal exposure device development, we report a colorimetric CO sensing platform, which achieves a detection limit of 1 ppm, dynamic range of 0 ~ 500 ppm, and high selectivity to CO over common interferents in air, such as CO2, NO2, SO2, and O3...
January 4, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29291239/seizure-forecasting-from-idea-to-reality-outcomes-of-the-my-seizure-gauge-epilepsy-innovation-institute-workshop
#17
Sonya B Dumanis, Jaqueline A French, Christophe Bernard, Gregory A Worrell, Brandy E Fureman
The Epilepsy Innovation Institute (Ei2) is a new research program of the Epilepsy Foundation designed to be an innovation incubator for epilepsy. Ei2 research areas are selected based on community surveys that ask people impacted by epilepsy what they would like researchers to focus on. In their 2016 survey, unpredictability was selected as a top issue regardless of seizure frequency or severity. In response to this need, Ei2 launched the My Seizure Gauge challenge, with the end goal of creating a personalized seizure advisory system device...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29239680/the-spots-system-an-ocular-scoring-system-optimized-for-use-in-modern-preclinical-drug-development-and-toxicology
#18
Joshua Seth Eaton, Paul E Miller, Ellison Bentley, Sara M Thomasy, Christopher J Murphy
PURPOSE: To present a semiquantitative ocular scoring system comprising elements and criteria that address many of the limitations associated with systems commonly used in preclinical studies, providing enhanced cross-species applicability and predictive value in modern ocular drug and device development. METHODS: Revisions to the ocular scoring systems of McDonald-Shadduck and Hackett-McDonald were conducted by board-certified veterinary ophthalmologists at Ocular Services On Demand (OSOD) over the execution of hundreds of in vivo preclinical ocular drug and device development studies and general toxicological investigations...
December 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29226723/pen-devices-for-self-injection-contrasting-measured-injection-force-with-users-perceived-ease-of-injection
#19
Andreas E Schneider, Jakob Lange
OBJECTIVES: Past research has emphasized injection force as a clinically highly relevant technical attribute of pen devices. However, little work has been conducted to relate these results to in-use studies. This article explores whether and how differences in pen injection force profiles influence users' self-reported perceived ease of injection and preferences. METHODS: Three different pen systems were subjected to measurements of injection force using an automated mechanical set-up followed by a simulated use study where users assessed perceived ease of injection...
December 9, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29222625/using-patient-feedback-to-optimize-the-design-of-a-certolizumab-pegol-electromechanical-self-injection-device-insights-from-human-factors-studies
#20
Barbara Domańska, Oliver Stumpp, Steven Poon, Serkan Oray, Irina Mountian, Clovis Pichon
INTRODUCTION: We incorporated patient feedback from human factors studies (HFS) in the patient-centric design and validation of ava®, an electromechanical device (e-Device) for self-injecting the anti-tumor necrosis factor certolizumab pegol (CZP). METHODS: Healthcare professionals, caregivers, healthy volunteers, and patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or Crohn's disease participated in 11 formative HFS to optimize the e-Device design through intended user feedback; nine studies involved simulated injections...
December 8, 2017: Advances in Therapy
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