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"Device development"

Terrence R Tiersch, William T Monroe
Development of devices through design, prototyping, testing, and fabrication is especially necessary for enhancement of research and eventual application in cryobiology. The advent of 3-dimensional printing offers unique opportunities for this process, given that the materials involved are suitable for use in cryogenic temperatures. We report herein that 3-D printing with polylactic acid (PLA) thermoplastic is ideally suited for cryobiology device development. Devices that are designed and standardized in open-source fashion can be electronically distributed and created locally on increasingly affordable 3-D printers, and can accelerate cryobiology findings and improve reproducibility of results...
October 18, 2016: Cryobiology
Tilman R Rohrer, Reiko Horikawa, Anne-Marie Kappelgaard
Adherence to daily growth hormone (GH) injections optimizes treatment benefit; however, adherence rates are sometimes poor. Reasons for poor adherence and persistence are multifaceted. GH injection devices are undergoing continual improvement to enhance adherence. Areas covered: This review evaluates published data on the evolution of GH injection devices to meet patients' needs and preferences, patients' perception of new devices and the projected impact of device developments on adherence. Published studies were identified through literature database searches including EMBASE and PubMed (January 1985-November 2015)...
October 10, 2016: Expert Opinion on Drug Delivery
Mandar M Shirolkar, Xiaolei Dong, Jieni Li, Shiliu Yin, Ming Li, Haiqian Wang
Particle size significantly affects the properties and therefore the potential applications of multiferroics. However, is there special particle size effect in BiFeO3, which has a spiral modulated spin structure? This is still under investigation for sub-5 nm BiFeO3. In this report, the structural, electronic and magnetic properties are investigated for chemically synthesized BiFeO3 nanoparticles with an average size of 3 nm. We observed nanotwinning features in the specific size regime of the nanoparticles (2-4 nm)...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
Myron Spector
No abstract text is available yet for this article.
October 6, 2016: Biomedical Materials
Jiangwei Liu, Hirotaka Ohsato, Xi Wang, Meiyong Liao, Yasuo Koide
The lack of large-area single-crystal diamond wafers has led us to downscale diamond electronic devices. Here, we design and fabricate a hydrogenated diamond (H-diamond) triple-gate metal-oxide-semiconductor field-effect transistor (MOSFET) to extend device downscaling and increase device output current. The device's electrical properties are compared with those of planar-type MOSFETs, which are fabricated simultaneously on the same substrate. The triple-gate MOSFET's output current (174.2 mA mm(-1)) is much higher than that of the planar-type device (45...
October 6, 2016: Scientific Reports
Paul J Ponganis
A new automated blood sampler for seals is only the third such device developed for research with higher marine vertebrates.
October 5, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Stanislav A Evlashin, Pavel Dyakonov, Roman Khmelnitsky, Sarkis Dagesyan, Andrey Klokov, Andrey Sharkov, Peter S Timashev, Svetlana Minaeva, Konstantin I Maslakov, Sergey Svyakhovskiy, Nikolay V Suetin
This article presents a new simple method of creating light absorbing carbon material for optical devices such as bolometers. A simple method of laser microstructuring of graphene oxide is used in order to create such material. The absorption values of more than 98% in the visible and more than 90% in the IR range are achieved. Moreover thermal properties of the films, such as temperature dependence and the thermal response of the samples are studied. The change in resistance with temperature is 13 Ohm K(-1), temperature coefficient of resistance (TCR) 0...
October 5, 2016: ACS Applied Materials & Interfaces
Michael Rosenblatt, Marc M Boutin, Samuel R Nussbaum
No abstract text is available yet for this article.
September 26, 2016: JAMA: the Journal of the American Medical Association
Susan L Deems-Dluhy, Chandrasekaran Jayaraman, Steve Green, Mark V Albert, Arun Jayaraman
BACKGROUND: Difficulty ascending ramps and inclines with a manual wheelchair adversely affects the everyday mobility and overall quality of life of manual wheelchair users. Currently, various anti-rollback devices are available to assist manual wheelchair users to ascend ramps and inclines. However, these devices have 2 main shortcomings: restriction to backward motion limiting recovery from an overturning wheelie, which is a safety concern; and difficulty in engaging/disengaging the device while on the ramp...
September 21, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
(no author information available yet)
This final rule details the requirements for submitting registration and summary results information, including adverse event information, for specified clinical trials of drug products (including biological products) and device products and for pediatric postmarket surveillances of a device product to, the clinical trial registry and results data bank operated by the National Library of Medicine (NLM) of the National Institutes of Health (NIH). This rule provides for the expanded registry and results data bank specified in Title VIII of the Food and Drug Administration Amendments Act of 2007 (FDAAA) to help patients find trials for which they might be eligible, enhance the design of clinical trials and prevent duplication of unsuccessful or unsafe trials, improve the evidence base that informs clinical care, increase the efficiency of drug and device development processes, improve clinical research practice, and build public trust in clinical research...
September 21, 2016: Federal Register
Shaheen Hasmat, Nigel H Lovell, Gregg J Suaning, Tsu-Hui Hubert Low, Jonathan Clark
The most devastating outcome of facial nerve paralysis is the inability to completely close the eye as it can lead to corneal ulceration and loss of vision. Gravity-assisted eye closure with upper lid loading is commonly used; however it is limited in replicating physiological eye closure to adequately lubricate the cornea. Superior results can be obtained using more advanced reconstructive approaches, however they depend on nerve regrowth which may be unpredictable and prolonged. This report describes a novel technique for creating an active eye closure using an implantable actuator...
September 7, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Luigi F Cuturi, Elena Aggius-Vella, Claudio Campus, Alberto Parmiggiani, Monica Gori
The last quarter of a century has seen a dramatic rise of interest in the development of technological solutions for visually impaired people. However, despite the presence of many devices, user acceptance is low. Not only are visually impaired adults not using these devices but they are also too complex for children. The majority of these devices have been developed without considering either the brain mechanisms underlying the deficit or the natural ability of the brain to process information. Most of them use complex feedback systems and overwhelm sensory, attentional and memory capacities...
September 5, 2016: Neuroscience and Biobehavioral Reviews
R M Gibson, A M Owen, D Cruse
The disorders of consciousness refer to clinical conditions that follow a severe head injury. Patients diagnosed as in a vegetative state lack awareness, while patients diagnosed as in a minimally conscious state retain fluctuating awareness. However, it is a challenge to accurately diagnose these disorders with clinical assessments of behavior. To improve diagnostic accuracy, neuroimaging-based approaches have been developed to detect the presence or absence of awareness in patients who lack overt responsiveness...
2016: Progress in Brain Research
S Z Zhong, C H Fang
In recent years, the three-dimentional(3D)printing technology is gradually applied in medicine.Now, the 3D printing has already play an important role in medical education, surgical device development, prosthesis implantation and so on.There are still many challenges and difficulties in the clinical overall application of 3D printing for some time, but it also contains a huge application prospect.Once with appropriate applications of this technology, it will be a major breakthrough in iatrical history once more...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Csilla Vér, Miklós Emri, Tamás Spisák, Ervin Berényi, Kázmér Kovács, Péter Katona, László Balkay, László Menyhárt, László Kardos, László Csiba
BACKGROUND: This study aims at investigating the short-term efficacy of the continuous passive motion (CPM) device developed for the therapy of ankle-foot paresis and to investigate by fMRI the blood oxygen level-dependent responses (BOLD) during ankle passive movement (PM). METHODS: Sixty-four stroke patients were investigated. Patients were assigned into 2 groups: 49 patients received both 15 min manual and 30 min device therapy (M + D), while the other group (n = 15) received only 15 min manual therapy (M)...
August 31, 2016: European Neurology
Marina V Makarova, Yuji Okawa, Elisseos Verveniotis, Kenji Watanabe, Takashi Taniguchi, Christian Joachim, Masakazu Aono
The electrical characterization of single-polymer chains on a surface is an important step towards novel molecular device development. The main challenge is the lack of appropriate atomically flat insulating substrates for fabricating single-polymer chains. Here, using atomic force microscopy, we demonstrate that the (0001) surface of an insulating hexagonal boron nitride (h-BN) substrate leads to a flat-lying self-assembled monolayer of diacetylene compounds. The subsequent heating or ultraviolet irradiation can initiate an on-surface polymerization process leading to the formation of long polydiacetylene chains...
September 30, 2016: Nanotechnology
S A Ranamukhaarachchi, S Lehnert, S L Ranamukhaarachchi, L Sprenger, T Schneider, I Mansoor, K Rai, U O Häfeli, B Stoeber
Collecting human skin samples for medical research, including developing microneedle-based medical devices, is challenging and time-consuming. Researchers rely on human skin substitutes and skin preservation techniques, such as freezing, to overcome the lack of skin availability. Porcine skin is considered the best substitute to human skin, but their mechanical resemblance has not been fully validated. We provide a direct mechanical comparison between human and porcine skin samples using a conventional mechano-analytical technique (microindentation) and a medical application (microneedle insertion), at 35% and 100% relative humidity...
2016: Scientific Reports
Zixian Jia, Antoine Rousseau
Sorbent-TRACK is a new device developed to monitor adsorption and surface oxidation of pollutants under direct plasma exposure. It is based on direct transmitted Fourier Transformed Infrared (FTIR) spectroscopy. A pyrex reactor under controlled gas pressure and composition is inserted on the infrared beam of a commercially available Nicolet 5700 FTIR spectrometer. A substrate holder is located on the optical path of the infrared beam. A thin pellet of a dedicated catalyst (CeO2 in the present work) is inserted in a substrate holder and can be exposed to direct plasma treatment using a Dielectric Barrier Discharge...
2016: Scientific Reports
Tomoya Tsukada, Masahide Kaji, Jun Kinoshita, Koichi Shimizu
BACKGROUND AND OBJECTIVES: Laparoscopic anastomotic methods are not commonly used because of the cumbersome laparoscopic intracorporeal sutures and tying involved. The barbed suture is one of the various devices developed to simplify the placement of intracorporeal sutures. However, barbed sutures are not commonly used during reconstruction after radical gastrectomy in cancer patients or for single-layer entire-thickness running suturing for intestinal anastomoses. We describe the procedure for using barbed sutures and report on the short-term surgical outcomes...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Natalia I Ossetrova, William F Blakely, Vitaly Nagy, Camille McGann, Patrick H Ney, Christine L Christensen, Amory L Koch, Jatinder Gulani, George B Sigal, Eli N Glezer, Kevin P Hieber
An assessment of multiple biomarkers from radiation casualties undergoing limited- or full-supportive care including treatment with filgrastim is critical to develop rapid and effective diagnostic triage strategies. The efficacy of filgrastim with full-supportive care was compared with results with limited-supportive care by analyzing survival, necropsy, histopathology and serial blood samples for hematological, serum chemistry and protein profiles in a non-human primate (Macaca mulatta, male and female) model during 60-d post-monitoring period following sham- and total-body irradiation with 6...
July 29, 2016: Radiation Protection Dosimetry
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