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https://www.readbyqxmd.com/read/29041456/cylindrical-vector-resonant-modes-achieved-in-planar-photonic-crystal-cavities-with-enlarged-air-holes
#1
Kang Chang, Liang Fang, Chenyang Zhao, Jianlin Zhao, Xuetao Gan
We reveal a triangular-lattice planar photonic crystal supports Bloch modes with radially and azimuthally symmetric electric field distributions at the top band-edge of the first photonic band. Bifurcated from the corresponding Bloch modes, two cylindrical vector resonant modes are achieved by simply enlarging the central air-hole of the planar photonic crystal, which have high quality factors around 3,000 and small mode volume of (λ/n)(3). The far-field radiations of the two resonant modes present high-quality cylindrical vector beam profiles...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29037270/micron-scale-deformation-a-coupled-in-situ-study-of-strain-bursts-and-acoustic-emission
#2
Ádám István Hegyi, Péter Dusán Ispánovity, Michal Knapek, Dániel Tüzes, Kristián Máthis, František Chmelík, Zoltán Dankházi, Gábor Varga, István Groma
Plastic deformation of micron-scale crystalline materials differs considerably from bulk samples as it is characterized by stochastic strain bursts. To obtain a detailed picture of the intermittent deformation phenomena, numerous micron-sized specimens must be fabricated and tested. An improved focused ion beam fabrication method is proposed to prepare non-tapered micropillars with excellent control over their shape. Moreover, the fabrication time is less compared with other methods. The in situ compression device developed in our laboratory allows high-accuracy sample positioning and force/displacement measurements with high data sampling rates...
October 17, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29033104/progesterone-releasing-devices-for-cattle-estrus-induction-and-synchronization-device-optimization-to-anticipate-shorter-treatment-durations-and-new-device-developments
#3
W de Graaff, B Grimard
Synchronization programs using progesterone-releasing intravaginal devices that allow for fixed time artificial insemination are still finding increasing application in bovine reproduction. This practice is useful for rationalizing livestock management because an increased number of cows can be inseminated in one session without the need for estrus detection. Although much of the innovation related to the design and development of intravaginal devices for use in cattle took place in the previous century, progress in understanding the physiology of the bovine estrous cycle resulted in shorter treatment durations, a trend which is still continuing...
September 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/29031303/current-advances-and-challenges-in-microfluidic-free-flow-electrophoresis-a-critical-review
#4
REVIEW
Pedro Novo, Dirk Janasek
The research field on microfluidic free-flow electrophoresis has developed vast amounts of devices, methods, applications and raised new questions, often in analogy to conventional techniques from which it derives. Most efforts have been employed on device development and a myriad of architectures and fabrication techniques have been reported using simple proof-of-principle separations. As technological aspects reach a quite mature state, researchers' new challenges include the development of protocols for the separation of complex mixtures, as required in the fields of application...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#5
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28973987/creating-active-device-materials-for-nanoelectronics-using-block-copolymer-lithography
#6
Cian Cummins, Alan P Bell, Michael A Morris
The prolonged and aggressive nature of scaling to augment the performance of silicon integrated circuits (ICs) and the technical challenges and costs associated with this has led to the study of alternative materials that can use processing schemes analogous to semiconductor manufacturing. We examine the status of recent efforts to develop active device elements using nontraditional lithography in this article, with a specific focus on block copolymer (BCP) feature patterning. An elegant route is demonstrated using directed self-assembly (DSA) of BCPs for the fabrication of aligned tungsten trioxide (WO₃) nanowires towards nanoelectronic device application...
September 30, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28956820/raman-computational-and-experimental-studies-of-dopamine-detection
#7
John D Ciubuc, Kevin E Bennet, Chao Qiu, Matthew Alonzo, William G Durrer, Felicia S Manciu
A combined theoretical and experimental analysis of dopamine (DA) is presented in this work with the objective of achieving more accurate detection and monitoring of this neurotransmitter at very low concentrations, specific to physiological levels. Surface-enhanced Raman spectroscopy on silver nanoparticles was employed for recording DA concentrations as low as 10(-11) molar. Quantum chemical density functional calculations were carried out using Gaussian-09 analytical suite software. Relatively good agreement between the simulated and experimentally determined results indicates the presence of different DA molecular forms, such as uncharged DA(±), anionic DA(-), and dopaminequinone...
September 28, 2017: Biosensors
https://www.readbyqxmd.com/read/28941247/wear-testing-of-a-canine-hip-resurfacing-implant-using-highly-cross-linked-polyethylene
#8
Kevin J Warburton, John B Everingham, Jillian L Helms, Andrew J Kazanovicz, Katherine A Hollar, Jeff D Brourman, Steven M Fox, Trevor J Lujan
Hip resurfacing offers advantages for young active patients afflicted with hip osteoarthritis, and may also be a beneficial treatment for adult canines. Conventional hip resurfacing uses metal-on-metal bearings to preserve bone stock, but it may be feasible to use metal-on-polyethylene bearings to reduce metal wear debris, while still preserving bone. This study characterized the short-term wear behavior of a novel hip resurfacing implant for canines that uses a 1.5 mm thick liner of highly cross-linked polyethylene in the acetabular component...
September 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28940163/predicting-the-dimensions-of-an-intracardiac-partial-assist-pump-for-percutaneous-delivery-by-analytical-and-numerical-methods
#9
Robert E Smith, P Alex Smith, William E Cohn
A minimally invasive ventricular assist device is under development for percutaneous insertion into the left atrium via transseptal access from the right atrium (RA). This study aimed to mathematically describe the vascular anatomy along possible insertion pathways to determine the device's maximum outer dimensions. We developed 2-dimensional mathematical models describing the vascular anatomy to the RA from three access points: subclavian vein (SCV), internal jugular vein (IJV), and femoral vein (FV). All pathways terminated by turning from the superior or inferior vena cava (SVC/IVC) into the RA...
September 22, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28938307/design-and-development-of-a-miniaturized-percutaneously-deployable-wireless-left-ventricular-assist-device-early-prototypes-and-feasibility-testing
#10
Brian Letzen, Jiheum Park, Zeynep Tuzun, Pramod Bonde
The current left ventricular assist devices (LVADs) are limited by a highly invasive implantation procedure in a severely unstable group of advanced heart failure patients. Additionally, the current transcutaneous power drive line acts as a nidus for infection resulting in significant morbidity and mortality. In an effort to decrease this invasiveness and eliminate drive line complications, we have conceived a wireless miniaturized percutaneous LVAD, capable of being delivered endovascularly with a tether-free operation...
September 21, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28923774/endotoxin-adsorption-direct-hemoperfusion-with-the-polymyxin-b-immobilized-fiber-column-pmx
#11
REVIEW
Tomoharu Shimizu, Toru Miyake, Naomi Kitamura, Masaji Tani, Yoshihiro Endo
Toraymyxin(®) is a medical device developed to adsorb circulating endotoxins in the blood using direct hemoperfusion therapy for patients with septic shock. In 1994, the Japanese National Health Insurance system approved the use of Toraymyxin for the treatment of endotoxemia and septic shock. Since then, Toraymyxin has been safely used in more than 100,000 cases in emergency and intensive care units in Japan. Toraymyxin is currently available for use in the clinical setting in 14 countries worldwide. In this study, we reviewed and introduced the development, clinical use, and efficacy of Toraymyxin and commented on its anticoagulant use and cartridge clotting issue in the treatment of severe sepsis and septic shock...
August 31, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28917987/development-and-characterisation-of-electrospun-timolol-maleate-loaded-polymeric-contact-lens-coatings-containing-various-permeation-enhancers
#12
Prina Mehta, Ali A Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Despite exponential growth in research relating to sustained and controlled ocular drug delivery, anatomical and chemical barriers of the eye still pose formulation challenges. Nanotechnology integration into the pharmaceutical industry has aided efforts in potential ocular drug device development. Here, the integration and in vitro effect of four different permeation enhancers (PEs) on the release of anti-glaucoma drug timolol maleate (TM) from polymeric nanofiber formulations is explored. Electrohydrodynamic (EHD) engineering, more specifically electrospinning, was used to engineer nanofibers (NFs) which coated the exterior of contact lenses...
September 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28904394/ultraviolet-b-light-emitting-diodes-leds-are-more-efficient-and-effective-in-producing-vitamin-d3-in-human-skin-compared-to-natural-sunlight
#13
T A Kalajian, A Aldoukhi, A J Veronikis, K Persons, M F Holick
Vitamin D, the sunshine vitamin is important for health. Those with fat malabsorption disorders malabsorb vitamin D and thus must rely on cutaneous production of vitamin D3. Vitamin D3 is generated secondary to exposure to ultraviolet B (UVB) radiation (whether from the sun or from an artificial source). Light emitting diodes (LEDs) have been developed to emit ultraviolet radiation. Little is known about the efficiency of UVB emitting LEDs tuned to different wavelengths for producing vitamin D3 in human skin...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886558/glyphosate-and-ampa-passive-sampling-in-freshwater-using-a-microporous-polyethylene-diffusion-sampler
#14
Vincent Fauvelle, Natalia Montero, Jochen F Mueller, Andrew Banks, Nicolas Mazzella, Sarit L Kaserzon
Glyphosate (PMG) is one of the most widely used herbicides with a reported 8.6 million tons applied globally in 2016. Due to widespread use and limited understanding of long-term environmental impacts, it is expected that future monitoring requirements for PMG and its primary metabolite aminomethyl phosphonic acid (AMPA) in aquatic environments will increase, along with the need for low cost monitoring and risk assessment strategies. The aim of this study was to investigate a microporous polyethylene tube (MPT; 2-mm thickness, 17...
August 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28883226/rapid-globalization-of-medical-device-clinical-development-programs-in-japan%C3%A3-the-case-of-drug-eluting-stents
#15
Madoka Murakami, Yuka Suzuki, Toshiyoshi Tominaga
Delays in the introduction to the Japanese market of drug-eluting stents (DES) developed overseas (i.e., "device lag") decreased sharply between 2004 and 2012. The reduction accompanied a shift in clinical development from a succession pattern (initial product development and approval overseas followed by eventual entrance into the Japanese market) to parallel development (employing multiregional clinical trials (MRCTs)). Although resource-intensive in the short-term, MRCTs are proving to be an effective tool in simultaneous global product development...
September 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28877750/mit-skywalker-considerations-on-the-design-of-a-body-weight-support-system
#16
Rogério Sales Gonçalves, Hermano Igo Krebs
BACKGROUND: To provide body weight support during walking and balance training, one can employ two distinct embodiments: support through a harness hanging from an overhead system or support through a saddle/seat type. This paper presents a comparison of these two approaches. Ultimately, this comparison determined our selection of the body weight support system employed in the MIT-Skywalker, a robotic device developed for the rehabilitation/habilitation of gait and balance after a neurological injury...
September 6, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28874215/participatory-design-of-pediatric-upper-limb-prostheses-qualitative-methods-and-prototyping
#17
Tara Sims, Andy Cranny, Cheryl Metcalf, Paul Chappell, Maggie Donovan-Hall
OBJECTIVES: The study aims to develop an understanding of the views of children and adolescents, parents, and professionals on upper limb prosthetic devices to develop and improve device design. Previous research has found that children are dissatisfied with prostheses but has relied heavily on parent proxy reports and quantitative measures (such as questionnaires) to explore their views. METHODS: Thirty-four participants (eight children aged 8-15 years with upper limb difference, nine parents, eight prosthetists, and nine occupational therapists) contributed to the development of new devices through the BRIDGE methodology of participatory design, using focus groups and interviews...
September 6, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28873838/overview-of-robotic-devices-for-nursing-care-project
#18
Hirohisa Hirukawa
METI/AMED are conducting a project on the development and deployment of robotic devices for nursing care to enhance the autonomy of elderly persons and assist care givers. An evaluation protocol is presented and the devices developed in the project are introduced. The devices consist of transfer assist devices (wearable/non-wearable), walking assist devices (outdoor/indoor), safety surveillance sensors (nursing home/private home), bath lift and toilet assist.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28870312/recent-advances-in-microfluidic-sample-preparation-and-separation-techniques-for-molecular-biomarker-analysis-a-critical-review
#19
REVIEW
Mukul Sonker, Vishal Sahore, Adam T Woolley
Microfluidics is a vibrant and expanding field that has the potential for solving many analytical challenges. Microfluidics show promise to provide rapid, inexpensive, efficient, and portable diagnostic solutions that can be used in resource-limited settings. Researchers have recently reported various microfluidic platforms for biomarker analysis applications. Sample preparation processes like purification, preconcentration and labeling have been characterized on-chip. Additionally, improvements in microfluidic separation techniques have been reported for molecular biomarkers...
September 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28862633/nanosecond-pump-probe-device-for-time-resolved-serial-femtosecond-crystallography-developed-at-sacla
#20
Minoru Kubo, Eriko Nango, Kensuke Tono, Tetsunari Kimura, Shigeki Owada, Changyong Song, Fumitaka Mafuné, Ken Miyajima, Yoshihiro Takeda, Jun Ya Kohno, Naoya Miyauchi, Takanori Nakane, Tomoyuki Tanaka, Takashi Nomura, Jan Davidsson, Rie Tanaka, Michio Murata, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Richard Neutze, Makina Yabashi, So Iwata
X-ray free-electron lasers (XFELs) have opened new opportunities for time-resolved X-ray crystallography. Here a nanosecond optical-pump XFEL-probe device developed for time-resolved serial femtosecond crystallography (TR-SFX) studies of photo-induced reactions in proteins at the SPring-8 Angstrom Compact free-electron LAser (SACLA) is reported. The optical-fiber-based system is a good choice for a quick setup in a limited beam time and allows pump illumination from two directions to achieve high excitation efficiency of protein microcrystals...
September 1, 2017: Journal of Synchrotron Radiation
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