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https://www.readbyqxmd.com/read/29691261/serum-vancomycin-concentrations-after-oral-and-intracolonic-vancomycin-administration-in-a-patient-with-colonic-discontinuity-and-severe-clostridium-difficile-infection
#1
Katja Wilke, Sina Helbig, Katja de With
PURPOSE: A case of detectable systemic vancomycin levels after oral vancomycin administration but not after intracolonic administration in a patient with colonic discontinuity and severe Clostridium difficile infection (CDI) is reported. SUMMARY: A 63-year-old woman who had recently undergone pancreas-kidney transplantation developed severe CDI after 13 days of meropenem therapy for presumed urosepsis. Meropenem was stopped immediately, and treatment with oral vancomycin (250 mg every 6 hours) was started...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29689547/sirt3-facilitates-amniotic-fluid-stem-cells-to-repair-diabetic-nephropathy-through-protecting-mitochondrial-homeostasis-by-modulation-of-mitophagy
#2
Jianxun Feng, Chang Lu, Qin Dai, Junqin Sheng, Min Xu
BACKGROUND/AIMS: Amniotic fluid stem cells (AFSCs) transplantation is a promising therapeutic strategy for diabetic nephropathy. Sirtuin3 (SIRT3) is a novel mitochondrial protective factor. In the present study, we aimed to investigate whether SIRT3 protects against hyperglycemia-induced AFSCs damage and enhances the therapeutic efficiency of AFSCs in diabetic nephropathy. METHODS: To establish the diabetic nephropathy model, db/ db mice were used. AFSCs were obtained and transplanted into the kidney tissue of db/ db mice...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689120/acute-on-chronic-liver-failure-getting-ready-for-prime-time
#3
Jasmohan S Bajaj, Richard Moreau, Patrick S Kamath, Hugo E Vargas, Vicente Arroyo, K Rajender Reddy, Gyongyi Szabo, Puneeta Tandon, Jody Olson, Constantine Karvellas, Thierry Gustot, Jennifer C Lai, Florence Wong
Acute on chronic liver failure (ACLF) is a culmination of chronic liver disease and extra-hepatic organ failures, which is associated with a high short-term mortality and immense healthcare expenditure. There are varying definitions for organ failures and ACLF in Europe, North America and Asia. These differing definitions need to be reconciled to enhance progress in the field. The pathogenesis of ACLF is multi-factorial and related to interactions between the immuno-inflammatory system, microbiota and the precipitating factors...
April 24, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29688998/persistent-alpha-galactosidase-a-deficiency-following-simultaneous-liver-kidney-transplantation-in-a-patient-with-fabry-disease
#4
Alisa Likhitsup, John H Helzberg, Laura M Alba, Meghan K Larkin, Lee S Cummings, Eddie R Island, Ryan M Lustig, Jameson Forster
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688997/successful-kidney-transplant-from-donor-with-carbon-monoxide-poisoning
#5
Eric Siskind, Johann Jonsson
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688995/correlation-between-kidney-transplant-outcome-metrics-and-waitlist-metrics
#6
Sheng Zhou, Courtenay M Holscher, Allan B Massie, Dorry L Segev, Lauren Hersch Nicholas
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688993/british-transplantation-society-renal-association-uk-guidelines-for-living-donor-kidney-transplantation-2018-summary-of-updated-guidance
#7
Peter A Andrews, Lisa Burnapp
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688992/long-term-outcomes-of-kidney-transplantation-in-fabry-disease
#8
Sara Ersözlü, Robert J Desnick, Uyen Huynh-Do, Sima Canaan-Kühl, Frédéric Barbey, Vera Genitsch, Thomas Müller, Marcus Cheetham, Andreas Flammer, Stefan Schaub, Albina Nowak
BACKGROUND: Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene that obliterate or markedly reduce α-galactosidase A activity. This results in the systemic accumulation of its glycosphingolipid substrates in body fluids and organs, including the kidney. Fabry nephropathy can lead to end-stage renal disease requiring kidney transplantation. Little is known about its long-term outcomes and the overall patient survival after kidney transplantation...
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688849/cryptococcoma-of-a-transplanted-kidney-in-a-patient-presenting-with-recurrent-urinary-tract-infection-a-case-report
#9
Albert Z Muranda, Ludolf Greeff, Mike M Sathekge, Thabo Lengano, Victor O L Karusseit
BACKGROUND: Cryptococcosis is an important opportunistic infection of organ transplant recipients. It is the third most common fungal infection of transplant patients and occurs especially in kidney recipients. Cryptococcus neoformans is a ubiquitous fungus which infects humans by inhalation of spores. C. gattii has more recently been recognised as a pathogen. Infection commonly is disseminated affecting mainly the central nervous system and the lungs. Cryptococcoma, a localised form of the disease, has been described in various organs...
April 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29687948/hepatitis-c-virus-infected-kidney-wait-list-patients-treat-now-or-treat-later
#10
B A Kiberd, K Doucette, A J Vinson, K K Tennankore
Currently many but not all centers transplant HCV viremic positive (+) donor kidneys into HCV+ recipients. Directed donation of HCV+ organs reduces the wait time to transplantation for HCV+ patients. Direct acting antiviral (DAA) therapy has the ability to cure HCV in virtually all infected. Some have suggested that treatment of HCV+ wait listed patients be deferred with the hope that earlier transplantation will provide better outcomes than early DAA therapy. However there are not enough organs to guarantee prompt transplantation for the current wait list of infected candidates...
April 24, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29687570/should-we-formulate-an-incentivized-model-facilitating-kidney-donation-from-living-donors-a-focus-on-turkey-s-current-system
#11
Ercan Avci
Kidney transplantation is a lifesaving medical treatment. However, very high demand for kidneys with low kidney donation causes a black market that exploits patients' desperation and donors' vulnerability. The current kidney donation programs fail to produce promising results to avoid illegal and unethical kidney trafficking and commercialism. Even though the primary goal of kidney donation is to increase the number of deceased organ donations, in some countries, like Turkey, due to religious or cultural concerns, it is impossible to supply adequate deceased kidney donations...
April 23, 2018: Developing World Bioethics
https://www.readbyqxmd.com/read/29687010/remaining-physiological-barriers-in-porcine-kidney-xenotransplantation-potential-pathways-behind-proteinuria-as-well-as-factors-related-to-growth-discrepancies-following-pig-to-kidney-xenotransplantation
#12
REVIEW
Jigesh A Shah, Miguel A Lanaspa, Tatsu Tanabe, Hironosuke Watanabe, Richard J Johnson, Kazuhiko Yamada
Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, cross-species solid organ transplantation, offers one potential solution to this dilemma. Previous extensive research dedicated to this field has allowed for resolution of xenograft failure due to acute rejection, leaving new areas of unresolved challenges as barriers to success in large animal models...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29686294/development-of-new-method-to-enrich-human-ipsc-derived-renal-progenitors-using-cell-surface-markers
#13
Azusa Hoshina, Tatsuya Kawamoto, Shin-Ichi Sueta, Shin-Ichi Mae, Toshikazu Araoka, Hiromi Tanaka, Yasunori Sato, Yukiko Yamagishi, Kenji Osafune
Cell therapy using renal progenitors differentiated from human embryonic stem cells (hESCs) or induced pluripotent stem cells (hiPSCs) has the potential to significantly reduce the number of patients receiving dialysis therapy. However, the differentiation cultures may contain undifferentiated or undesired cell types that cause unwanted side effects, such as neoplastic formation, when transplanted into a body. Moreover, the hESCs/iPSCs are often genetically modified in order to isolate the derived renal progenitors, hampering clinical applications...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685925/hla-dq-mismatching-and-kidney-transplant-outcomes
#14
Napat Leeaphorn, Jeremy Ryan A Pena, Natanong Thamcharoen, Eliyahu V Khankin, Martha Pavlakis, Francesca Cardarelli
BACKGROUND AND OBJECTIVES: Recent evidence suggests that HLA epitope-mismatching at HLA-DQ loci is associated with the development of anti-DQ donor-specific antibodies and adverse graft outcomes. However, the clinical significance of broad antigen HLA-DQ mismatching for graft outcomes is not well examined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the United Network Organ Sharing/the Organ Procurement and Transplantation Network (UNOS/OPTN) data, patients with primary kidney transplants performed between 2005 and 2014 were included...
April 23, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29685884/incidence-risk-factors-and-sequelae-of-post-kidney-transplant-delirium
#15
Christine E Haugen, Alexandra Mountford, Fatima Warsame, Rachel Berkowitz, Sunjae Bae, Alvin G Thomas, Charles H Brown, Daniel C Brennan, Karin J Neufeld, Michelle C Carlson, Dorry L Segev, Mara McAdams-DeMarco
Background Frail kidney transplant (KT) recipients may be particularly vulnerable to surgical stressors, resulting in delirium and subsequent adverse outcomes. We sought to identify the incidence, risk factors, and sequelae of post-KT delirium. Methods We studied 125,304 adult KT recipients (1999-2014) to estimate delirium incidence in national registry claims. Additionally, we used a validated chart abstraction algorithm to identify post-KT delirium in 893 adult recipients (2009-2017) from a cohort study of frailty...
April 23, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29685212/gathering-clues-to-explain-the-stagnation-in-living-donor-kidney-transplantation-in-the-united-states
#16
EDITORIAL
Jesse D Schold, Emilio D Poggio, Joshua J Augustine
No abstract text is available yet for this article.
May 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29684255/molecular-profiling-of-post-reperfusion-milieu-determines-acute-kidney-injury-after-liver-transplantation-a-prospective-study
#17
Carlo Pulitano, Phong Ho, Deborah Verran, Charbel Sandroussi, David Joseph, David G Bowen, Geoffrey W McCaughan, Michael Crawford, Nicholas Shackel
Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study is to investigate the potential relationship between post-reperfusion gene expression, serum mediators, and the onset of AKI after LT. Sixty-five consecutive patients undergoing LT were included in the study. Reverse transcription polymerase chain reaction (RT- PCR), was performed on liver biopsies. Gene expression of 23 genes involved in ischemia reperfusion injury (IRI) was evaluated...
April 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29684175/aminoglycoside-exposure-and-renal-function-before-lung-transplantation-in-adult-cystic-fibrosis-patients
#18
Etienne Novel-Catin, Solenne Pelletier, Quitterie Reynaud, Raphaele Nove-Josserand, Stephane Durupt, Laurence Dubourg, Isabelle Durieu, Denis Fouque
Background: Patients with cystic fibrosis (CF) are at risk of kidney injury even before undergoing lung transplantation, because of prolonged exposure to aminoglycosides (AGs), chronic dehydration and complications of diabetes mellitus. The usual equations estimating the glomerular filtration rate (GFR), such as Cockcroft-Gault and Modification of Diet in Renal Disease, are not adapted to the CF population due to patients' low body weight and reduced muscle mass. The aim of this study was to precisely measure GFR in adult CF patients and to see whether repeated AG treatment would impair renal function before lung transplantation...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29683999/normothermic-ex-vivo-kidney-perfusion-reduces-warm-ischemic-injury-of-porcine-kidney-grafts-retrieved-after-circulatory-death-dcd
#19
Matyas Hamar, Peter Urbanellis, Moritz Johann Kaths, Dagmar Kollmann, Ivan Linares, Sujani Ganesh, Aryn Wiebe, Jun Yu Cen, Paul M Yip, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, David R Grant, Lisa A Robinson, Markus Selzner
BACKGROUND: Cold storage is poorly tolerated by kidney grafts retrieved after Donation after Circulatory Death (DCD). It has been determined that normothermic ex vivo kidney perfusion (NEVKP) preservation decreases injury by minimizing cold ischemic storage. The impact of NEVKP on warm ischemic injury is unknown. METHODS: We compared pig kidneys retrieved after 30minutes warm ischemia and immediate transplantation (no-preservation) with grafts that were exposed to 30min of warm ischemia plus 8hr NEVKP or plus 8hr SCS...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683972/bladder-versus-enteric-drainage-of-exocrine-secretions-in-pancreas-transplantation-a-retrospective-analysis-of-the-united-network-for-organ-sharing-database
#20
Eric J Siskind, Leo I Amodu, Sonia Pinto, Meredith Akerman, Johann Jonsson, Ernesto P Molmenti, Jorge Ortiz
OBJECTIVES: The method for drainage of exocrine secretions in pancreas transplantation remains a matter of debate. Different methods have evolved over time. Most data on these methods are from single-center studies with small sample sizes. Larger studies have yielded conflicting results. METHODS: Data from the United Network for Organ Sharing database on all adult subjects who received pancreas and kidney-pancreas transplants between 1996 and 2012 were analyzed (n = 19,934)...
April 19, 2018: Pancreas
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