keyword
https://read.qxmd.com/read/38534759/the-beneficial-role-of-lactobacillus-paracasei-subsp-paracasei-ntu-101-in-the-prevention-of-atopic-dermatitis
#1
JOURNAL ARTICLE
Chin-Feng Liu, Tsung-Wei Shih, Chun-Lin Lee, Tzu-Ming Pan
Atopic dermatitis (AD) is a recurrent allergic disease characterized by symptoms such as itching, redness, swelling, dryness, scaling skin, inflammation, and tissue damage. The underlying pathogenesis of AD remains unclear. Steroid drugs are commonly used in the clinical treatment of AD; however, their long-term use may lead to associated complications. Numerous studies have indicated that probiotics could modulate the immune system, enhance immune function, or suppress excessive immune responses. In this study, Lactobacillus paracasei subsp...
March 9, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533529/adar2-deficiency-ameliorates-non-alcoholic-fatty-liver-disease-and-muscle-atrophy-through-modulating-serum-amyloid-a1
#2
JOURNAL ARTICLE
Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, Yun-Wen Chen
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLD. Adenosine-to-inosine editing, catalysed by adenosine deaminase acting on RNA (ADAR), is an important post-transcriptional modification of genome-encoded RNA transcripts. Three ADAR gene family members, including ADAR1, ADAR2 and ADAR3, have been identified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38532230/enhancing-oocyte-quality-in-aging-mice-insights-from-mesenchymal-stem-cell-therapy-and-foxo3a-signaling-pathway-activation
#3
JOURNAL ARTICLE
Lingjuan Wang, Yang Liu, Yinhua Song, Qiaojuan Mei, Hongbei Mou, Jiachen Wu, Xinyu Tang, Jihui Ai, Kezhen Li, Houxiu Xiao, Xiaotao Han, Liqun Lv, Huaibiao Li, Ling Zhang, Wenpei Xiang
Ovarian aging reduced the quality of oocytes, resulting in age-related female infertility. It is reported that mesenchymal stem cells (MSCs) therapy can improve age-related ovarian function decline and the success rate of in vitro maturation (IVM) in assisted reproductive therapy. In order to investigate the effectiveness and mechanisms of MSCs to enhance oocyte quality of cumulus oocyte complexes (COCs) in advanced age, this study focus on the respective functional improvement of oocytes and granulosa cells (GCs) from aging mice and further to explore and verify the possible mechanisms...
March 26, 2024: Reproductive Sciences
https://read.qxmd.com/read/38522565/astragalus-polysaccharides-ameliorates-experimental-colitis-by-regulating-memory-b-cells-metabolism
#4
JOURNAL ARTICLE
Yifei Deng, Lizhao Song, Jiaqi Huang, Wen Zhou, Yali Liu, Xiuyun Lu, Haimei Zhao, Duanyong Liu
It is well-established that the reduced Memory B cells (MBCs) play an important role in the pathogenesis of ulcerative colitis (UC), rendering them a potential therapeutic target for UC intervention. Astragalus polysaccharide (APS), a primary active constituent derived from the classic traditional Chinese medicine Astragalus membranaceus (AM), has been used for centuries in the treatment of UC in both human and animal subjects due to its renowned immunomodulatory properties. However, it is unknown whether APS can regulate MBCs to alleviate experimental colitis...
March 22, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38519275/exploratory-pilot-study-to-characterize-the-immune-landscapes-of-malignant-pleural-effusions-and-their-corresponding-primary-tumors-from-patients-with-breast-carcinoma-and-lung-adenocarcinoma
#5
JOURNAL ARTICLE
Caddie Laberiano-Fernandez, Qiong Gan, Sophia Mei Wang, Auriole Tamegnon, Ignacio Wistuba, Esther Yoon, Sinchita Roy-Chowdhuri, Edwin Roger Parra
INTRODUCTION: Malignant pleural effusion (MPE) is a frequent complication of advanced malignancies. In this pilot study, we characterized the immune landscapes of MPEs, compared them to their primary tumor (PT) samples from breast carcinoma (BC) and lung adenocarcinoma (LADC), and tested the utility of multiplexed image technology in cytological samples. MATERIALS AND METHODS: We evaluated the immune contexture of 6 BC and 5 LADC MPEs and their PTs using 3 multiplex immunofluorescence panels...
February 29, 2024: Journal of the American Society of Cytopathology
https://read.qxmd.com/read/38518980/regulatory-t-cells-supporting-lung-homeostasis-and-promoting-resolution-and-repair-after-lung-injury
#6
JOURNAL ARTICLE
Morgan J McCullough, Pria G Bose, Jason R Mock
Regulatory T cells, characterized by their expression of the transcription factor Forkhead box P3, are indispensable in maintaining immune homeostasis. The respiratory system is constantly exposed to many environmental challenges, making it susceptible to various insults and infections. Regulatory T cells play essential roles in maintaining homeostasis in the lung and promoting repair after injury. Regulatory T cell function dysregulation can lead to inflammation, tissue damage, or aberrant repair. Research on regulatory T cell mechanisms in the lung has unveiled their influence on lung inflammation and repair mechanisms...
March 20, 2024: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/38518842/silencing-of-forkhead-box-protein-o-1-foxo-1-enhances-insulin-producing-cell-generation-from-adipose-mesenchymal-stem-cells-for-diabetes-therapy
#7
JOURNAL ARTICLE
Mohamed M Kamal, Reham A Ammar, Dina H Kassem
AIMS: Generation of mature β-cells from MSCs has been a challenge in the field of stem cell therapy of diabetes. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) have made their mark in regenerative medicine, and provide several advantages compared to other MSCs sources. Forkhead box protein O-1 (FOXO-1) is an important transcription factor for normal development of β-cells, yet its over expression in β-cells may cause glucose intolerance. In this study, we isolated, characterized Ad-MSCs from rat epididymal fat pads, differentiated these MSCs into insulin producing cells (IPCs) and studied the role of FOXO-1 in such differentiation...
March 20, 2024: Life Sciences
https://read.qxmd.com/read/38514922/roles-of-histone-deacetylase-4-in-the-inflammatory-and-metabolic-processes
#8
REVIEW
Hyunju Kang, Young-Ki Park, Ji-Young Lee, Minkyung Bae
Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins, including transcription factors. The activity of HDAC4 is regulated at the transcriptional, post-transcriptional, and post-translational levels. The functions of HDAC4 are tissue-dependent in response to endogenous and exogenous factors and their substrates. In particular, the association of HDAC4 with non-histone targets, including transcription factors, such as myocyte enhancer factor 2, hypoxia-inducible factor, signal transducer and activator of transcription 1, and forkhead box proteins, play a crucial role in regulating inflammatory and metabolic processes...
March 22, 2024: Diabetes & Metabolism Journal
https://read.qxmd.com/read/38514643/vdr-and-deubiquitination-control-neuronal-oxidative-stress-and-microglial-inflammation-in-parkinson-s-disease
#9
JOURNAL ARTICLE
Zihui Zheng, Miao Chen, Shengliang Feng, Huanhuan Zhao, Tiange Qu, Xudong Zhao, Qinli Ruan, Lei Li, Jun Guo
Close correlation between vitamin D (VitD) deficiency and Parkinson's Disease (PD) risk, VitD as an adjuvant treatment promising to improve PD progression. However, VitD excessive intake could induce hypercalcemia and renal damage. Therefore, upregulation of vitD receptor (VDR) is considered a compensatory strategy to overcome VitD insufficiency and alleviate PD symptoms. In this study, we discovered that VDR played antioxidative roles in dopaminergic neurons by decreasing reactive oxygen species (ROS) and maintaining mitochondrial membrane potential...
March 21, 2024: Cell Death Discovery
https://read.qxmd.com/read/38512803/what-is-the-relevance-of-foxp3-in-the-tumor-microenvironment-and-cancer-outcomes
#10
JOURNAL ARTICLE
Abdo Meyiah, Eyad Elkord
INTRODUCTION: Forkhead box P3 (FoxP3) transcription factor plays critical roles in controlling immune responses and cancer progression in different cancers. FoxP3 expression within the tumor microenvironment (TME) may influence clinical outcomes negatively or positively, and it could play dual roles in cancer, either by promoting or inhibiting tumor development and progression. Some studies reported that high levels of FoxP3 could be associated with tumor progression and worse prognosis, while others reported contradictory results...
March 21, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38512300/participation-of-long-noncoding-rna-foxp4-as1-in-the-development-and-progression-of-endometrioid-carcinoma-with-epigenetically-silencing-dusp5
#11
JOURNAL ARTICLE
Leilei Liu, Jingyun Zhao, Hui Guo, Jingde Jia, Li Shi, Jing Ma, Zhengmao Zhang
Background: Long noncoding RNAs (lncRNAs), as emerging regulators of a wide variety of biological processes via diverse mechanisms, have been demonstrated to be of increasing importance in biology. Genome-wide association studies of tumor samples have identified several lncRNAs as either oncogenes or tumor suppressors in various types of cancers. In recent years, the importance of lncRNAs, especially in endometrioid cancer (EEC), has become increasingly well understood. The lncRNA Forkhead box P4 antisense RNA 1 (FOXP4-AS1) has been reported to fulfill roles in several types of cancers; however, the main biological function and associated underlying molecular mechanism of FOXP4-AS1 in EEC have yet to be fully elucidated...
March 20, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38505620/myocardin-reverses-insulin-resistance-and-ameliorates-cardiomyopathy-by-increasing-irs-1-expression-in-a-murine-model-of-lipodystrophy-caused-by-adipose-deficiency-of-vacuolar-h-atpase-v0d1-subunit
#12
JOURNAL ARTICLE
Wenlin Yuan, Hui Lin, Yuan Sun, Lihuan Liu, Meijuan Yan, Yujuan Song, Xiaofan Zhang, Xiangling Lu, Yipei Xu, Qiyue He, Kunfu Ouyang, Chenglin Zhang, Yong Pan, Yu Huang, Ying Li, Xifeng Lu, Jie Liu
Aim: Adipose tissue (AT) dysfunction that occurs in both obesity and lipodystrophy is associated with the development of cardiomyopathy. However, it is unclear how dysfunctional AT induces cardiomyopathy due to limited animal models available. We have identified vacuolar H+ -ATPase subunit Vo d1, encoded by Atp6v0d1 , as a master regulator of adipogenesis, and adipose-specific deletion of Atp6v0d1 ( Atp6v0d1 AKO ) in mice caused generalized lipodystrophy and spontaneous cardiomyopathy. Using this unique animal model, we explore the mechanism(s) underlying lipodystrophy-related cardiomyopathy...
2024: Theranostics
https://read.qxmd.com/read/38500269/foxo1-regulates-wound-healing-responses-in-human-gingival-fibroblasts
#13
JOURNAL ARTICLE
Leticia Rojas, Nicolás Tobar, Javier Espinoza, Susana Ríos, Constanza Martínez, Jorge Martínez, Dana T Graves, Patricio C Smith
BACKGROUND AND OBJECTIVE: Forkhead box-O 1 (FOXO1) is a transcription factor actively involved in oral wound healing at the epithelial barrier. However, less is known regarding the role of FOXO1 during the tissue repair response in the connective tissue compartment. This study explored the involvement of FOXO1 in the modulation of fibroblast activity related to wound healing. METHODS: Primary cultures of human gingival fibroblasts were obtained from four healthy young donors...
March 18, 2024: Journal of Periodontal Research
https://read.qxmd.com/read/38499786/ferritin-heavy-chain-supports-stability-and-function-of-the-regulatory-t-cell-lineage
#14
JOURNAL ARTICLE
Qian Wu, Ana Rita Carlos, Faouzi Braza, Marie-Louise Bergman, Jamil Z Kitoko, Patricia Bastos-Amador, Eloy Cuadrado, Rui Martins, Bruna Sabino Oliveira, Vera C Martins, Brendon P Scicluna, Jonathan Jm Landry, Ferris E Jung, Temitope W Ademolue, Mirko Peitzsch, Jose Almeida-Santos, Jessica Thompson, Silvia Cardoso, Pedro Ventura, Manon Slot, Stamatia Rontogianni, Vanessa Ribeiro, Vital Da Silva Domingues, Inês A Cabral, Sebastian Weis, Marco Groth, Cristina Ameneiro, Miguel Fidalgo, Fudi Wang, Jocelyne Demengeot, Derk Amsen, Miguel P Soares
Regulatory T (TREG) cells develop via a program orchestrated by the transcription factor forkhead box protein P3 (FOXP3). Maintenance of the TREG cell lineage relies on sustained FOXP3 transcription via a mechanism involving demethylation of cytosine-phosphate-guanine (CpG)-rich elements at conserved non-coding sequences (CNS) in the FOXP3 locus. This cytosine demethylation is catalyzed by the ten-eleven translocation (TET) family of dioxygenases, and it involves a redox reaction that uses iron (Fe) as an essential cofactor...
March 18, 2024: EMBO Journal
https://read.qxmd.com/read/38495278/anti-oxidative-stress-treatment-and-current-clinical-trials
#15
JOURNAL ARTICLE
Chun-Ye Zhang, Ming Yang
Oxidative stress disturbs the balance between the production of reactive oxygen species (ROS) and the detoxification biological process. It plays an important role in the development and progression of many chronic diseases. Upon exposure to oxidative stress or the inducers of ROS, the cellular nucleus undergoes some biological processes via different signaling pathways, such as stress adaption through the forkhead box O signaling pathway, inflammatory response through the IκB kinase/nuclear factor-κB signaling pathway, hypoxic response via the hypoxia-inducible factor/prolyl hydroxylase domain proteins pathway, DNA repair or apoptosis through the p53 signaling pathway, and antioxidant response through the Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2 signaling pathway...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38495135/foxm1-promotes-the-progression-of-non-small-cell-lung-cancer-by-inhibiting-mir-509-5p-expression-via-binding-to-the-mir-509-5p-promoter-region
#16
JOURNAL ARTICLE
Mengcha Tian, Jiaming Li, Huihui Wu, Yuying Wu
BACKGROUND: Forkhead box M1 (FOXM1) functions as a transcription factor and is consistently overexpressed in various cancers, including non-small-cell lung-, breast-, cervical-, and colorectal cancer. Its overexpression is associated with poor prognosis in patients with non-small-cell lung cancer, although the detailed mechanisms by which FOXM1 promotes the development of non-small-cell lung cancer remain unclear. OBJECTIVE: The mechanism of FOXM1 in migration, invasion, apoptosis, and viability of lung cancer cells was investigated...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38490272/cobalt-protoporphyrin-promotes-heme-oxygenase-1-expression-and-ameliorates-cardiac-dysfunction-in-long-term-fasting-mice
#17
JOURNAL ARTICLE
Masayuki Shiba, Takao Kato, Yuta Seko, Eri Minamino-Muta, Yohei Tanada, Takeshi Kimura, Koh Ono
BACKGROUND: The association between malnutrition and cardiac dysfunction has been reported. Heme oxygenase (HO)-1 played protective roles in the animals functioning as a myocardial infarction, heart failure, or cardiomyopathy model. We hypothesized that the administration of HO-1 inducer, cobalt protoporphyrin (CoPP) reduces oxidative stress and ameliorates cardiac systolic dysfunction in long-term fasting mice. METHODS: C57BL/6 J mice were classified into three groups: fed mice (fed group), 48-h fasting mice with a single intraperitoneal injection of the corresponding vehicle (fasting group), and 48-h fasting mice with a single intraperitoneal injection of 5 mg/kg CoPP (CoPP group)...
March 13, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38485044/roles-of-heat-shock-protein-a12a-in-the-development-of-diabetic-cardiomyopathy
#18
JOURNAL ARTICLE
Yunxiao Jia, Yunhao Yu, Chenxi Gao, Yuehua Li, Chuanfu Li, Zhengnian Ding, Qiuyue Kong, Li Liu
Long-term hyperglycemia can lead to diabetic cardiomyopathy (DCM), a main lethal complication of diabetes. However, the mechanisms underlying DCM development have not been fully elucidated. Heat shock protein A12A (HSPA12A) is the atypic member of HSP70 family. In the present study, we found that the expression of HSPA12A was upregulated in hearts of mice with streptozotocin (STZ)-induced diabetes, while ablation of HSPA12A improved cardiac systolic and diastolic dysfunction and increased cumulative survival of diabetic mice...
March 12, 2024: Cell Stress & Chaperones
https://read.qxmd.com/read/38466962/context-responsive-nanoparticle-derived-from-synthetic-zwitterionic-ionizable-phospholipids-in-targeted-crispr-cas9-therapy-for-basal-like-breast-cancer
#19
JOURNAL ARTICLE
Parikshit Moitra, David Skrodzki, Matthew Molinaro, Nivetha Gunaseelan, Dinabandhu Sar, Teresa Aditya, Dipendra Dahal, Priyanka Ray, Dipanjan Pan
The majority of triple negative breast cancers (TNBCs) are basal-like breast cancers (BLBCs), which tend to be more aggressive, proliferate rapidly, and have poor clinical outcomes. A key prognostic biomarker and regulator of BLBC is the Forkhead box C1 (FOXC1) transcription factor. However, because of its functional placement inside the cell nucleus and its structural similarity with other related proteins, targeting FOXC1 for therapeutic benefit, particularly for BLBC, continues to be difficult. We envision targeted nonviral delivery of CRISPR/Cas9 plasmid toward the efficacious knockdown of FOXC1...
March 11, 2024: ACS Nano
https://read.qxmd.com/read/38466341/forkhead-box-o-proteins-steering-the-course-of-stem-cell-fate
#20
REVIEW
Mengdi Cheng, Yujie Nie, Min Song, Fulin Chen, Yuan Yu
Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately balanced between maintaining their pluripotency and differentiating as needed. Disruptions in this balance can lead to a spectrum of diseases, underscoring the importance of unraveling the complex molecular mechanisms that govern stem cell fate. Forkhead box O (FOXO) proteins, a family of transcription factors, are at the heart of this intricate regulation, influencing a myriad of cellular processes such as survival, metabolism, and DNA repair...
March 11, 2024: Cell Regeneration
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