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https://www.readbyqxmd.com/read/28227669/green-lasers-are-beyond-power-limits-mandated-by-safety-standards
#1
M H Lee, K Fox, S Goldwasser, D W M Lau, B Aliahmad, M Sarossy, M H Lee, K Fox, S Goldwasser, D W M Lau, B Aliahmad, M Sarossy, B Aliahmad, M H Lee, K Fox, D W M Lau, M Sarossy, S Goldwasser
There has been an increasing number of reports of people losing vision from laser exposure from pocket laser pointers despite the safety limit of 1 milliwatt (1mW) imposed by the Australian government. We hypothesize that this is because commercially available red and green laser pointers are exceeding their labeled power outputs. We tested the power outputs of 4 red and 4 green lasers which were purchased for less than AUD$30 each. The average of 10 measurements was recorded for each laser. We found that 3 out of 4 red lasers conformed to the 1mW safety standard; in contrast, all of the green lasers exceeded this limit, with one of the lasers recording an output of 127...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227503/suitability-of-nitinol-electrodes-in-neural-prostheses-such-as-endovascular-neural-interfaces
#2
Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden, Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden, Sam E John, Stephen M Ronayne, David B Grayden, Nicholas L Opie, Kate E Fox, Giulia Gerboni, Thomas J Oxley, Yan T Wong, Gil S Rind
A major challenge facing neural prostheses is the development of electrodes that are well tolerated by the brain and body. A novel way to circumvent the need to perform an invasive craniotomy and penetration of the blood-brain barrier to implant electrodes, is to guide electrodes up into the cerebral veins and place electrodes on the vessel walls adjacent to neuronal populations. To aid in the development of these stent based devices, microelectrodes manufactured from Nitinol would allow electrodes to be implanted via a catheter and then once deployed, alter their shape to conform to the vessel walls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226419/evaluation-of-risk-factors-for-clostridium-difficile-infection-in-hematopoietic-stem-cell-transplant-recipients
#3
Tonya L Scardina, Elena Kang Martinez, Neelam Balasubramanian, Mary Fox-Geiman, Scott E Smith, Jorge P Parada
STUDY OBJECTIVES: The primary objective was to determine the impact of hematologic malignancies and/or conditioning regimens on the risk of developing Clostridium difficile infection (CDI) in patients undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives were to determine if traditional CDI risk factors applied to patients undergoing HSCT and to determine the presence of CDI markers of severity of illness among this patient population. DESIGN: Single-center, retrospective, case-control study...
February 22, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28225743/damage-control-resuscitation-in-patients-with-severe-traumatic-hemorrhage-a-practice-management-guideline-from-the-eastern-association-for-the-surgery-of-trauma
#4
Jeremy W Cannon, Mansoor A Khan, Ali S Raja, Mitchell J Cohen, John J Como, Bryan A Cotton, Joseph J Dubose, Erin E Fox, Kenji Inaba, Carlos J Rodriguez, John B Holcomb, Juan C Duchesne
BACKGROUND: The resuscitation of severely injured bleeding patients has evolved into a multi-modal strategy termed damage control resuscitation (DCR). This guideline evaluates several aspects of DCR including the role of massive transfusion (MT) protocols, the optimal target ratio of plasma (PLAS) and platelets (PLT) to red blood cells (RBC) during DCR, and the role of recombinant activated factor VII (rVIIa) and tranexamic acid (TXA). METHODS: Using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, a subcommittee of the Practice Management Guidelines (PMG) Section of EAST conducted a systematic review using MEDLINE and EMBASE...
March 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28225717/mobility-and-clinic-switching-among-postpartum-women-considered-lost-to-hiv-care-in-south-africa
#5
Kate Clouse, Sten H Vermund, Mhairi Maskew, Mark N Lurie, William MacLeod, Given Malete, Sergio Carmona, Gayle Sherman, Matthew P Fox
OBJECTIVE: Retention in HIV care, particularly among postpartum women, is a challenge to national antiretroviral therapy programs. Retention estimates may be underestimated because of unreported transfers. We explored mobility and clinic switching among patients considered lost to follow-up (LTFU). DESIGN: Observational cohort study. METHODS: Of 788 women initiating antiretroviral therapy during pregnancy at 6 public clinics in Johannesburg, South Africa, 300 (38...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28225339/latent-tuberculous-infection-in-household-contacts-of-multidrug-resistant-and-newly-diagnosed-tuberculosis
#6
G J Fox, N T Anh, N V Nhung, N T Loi, N B Hoa, L T Ngoc Anh, N K Cuong, T N Buu, G B Marks, D Menzies
BACKGROUND: Differences in the prevalence of latent tuberculous infection (LTBI) and tuberculosis (TB) disease among contacts of patients with multidrug-resistant TB (MDR-TB) and drug-susceptible TB are not well understood. OBJECTIVE: To compare the prevalence of tuberculin skin test (TST) positivity in household contacts of patients with MDR-TB and in contacts of patients never previously treated for TB ('new TB'). DESIGN: Consecutive patients with MDR-TB and their household contacts at nine urban district clinics in Viet Nam were screened for TB and LTBI, and followed up for 6 months...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28225023/traditional-chinese-medicine-suppresses-left-ventricular-hypertrophy-by-targeting-extracellular-signal-regulated-kinases-signaling-pathway-in-spontaneously-hypertensive-rats
#7
Xingjiang Xiong, Xiaochen Yang, Lian Duan, Wei Liu, Yun Zhang, Yongmei Liu, Pengqian Wang, Shengjie Li, Xiaoke Li
Chinese herbal medicine Bu-Shen-Jiang-Ya decoction (BSJYD) is reported to be beneficial for hypertension. Over expression of extracellular signal regulated kinases (ERK) pathway plays an important role in left ventricular hypertrophy (LVH). This study aimed to observe effects of BSJYD on LVH in spontaneously hypertensive rats (SHRs) and explore its possible mechanism on regulation of ERK pathway. Sixty 12-week-old SHRs were randomly allocated into 5 groups: BSJYD high dose group, middle dose group, low dose group, captopril group, and control group...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224974/differences-in-outcomes-in-patients-with-stable-coronary-artery-disease-managed-by-cardiologists-versus-non-cardiologists-the-international-prospective-clarify-registry
#8
Zofia Parma, Philippe Gabriel Steg, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim Fox, Jean-Claude Tardif, Joao Morais, Marco Alcocer Gamba, Stefan Kääb, Michał Tendera
INTRODUCTION    Clinical outcomes of patients with stable coronary artery disease (SCAD) may differ between those primarily managed by cardiologists versus non-cardiologists.  OBJECTIVES    Our main objective was to analyze the clinical outcomes of outpatients with SCAD in relation to the specialty of the managing physicians.  PATIENTS AND METHODS    We studied 32,468 outpatients with SCAD included in the CLARIFY registry, with up to 4 years follow-up data. Cardiologists provided medical care in 84...
January 20, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28222903/modified-mrna-vaccines-protect-against-zika-virus-infection
#9
Justin M Richner, Sunny Himansu, Kimberly A Dowd, Scott L Butler, Vanessa Salazar, Julie M Fox, Justin G Julander, William W Tang, Sujan Shresta, Theodore C Pierson, Giuseppe Ciaramella, Michael S Diamond
The emergence of ZIKV infection has prompted a global effort to develop safe and effective vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine encoding wild-type or variant ZIKV structural genes and tested immunogenicity and protection in mice. Two doses of modified mRNA LNPs encoding prM-E genes that produced virus-like particles resulted in high neutralizing antibody titers (∼1/100,000) that protected against ZIKV infection and conferred sterilizing immunity. To offset a theoretical concern of ZIKV vaccines inducing antibodies that cross-react with the related dengue virus (DENV), we designed modified prM-E RNA encoding mutations destroying the conserved fusion-loop epitope in the E protein...
February 16, 2017: Cell
https://www.readbyqxmd.com/read/28222733/educational-health-disparities-in-hypertension-and-diabetes-mellitus-among-african-descent-populations-in-the-caribbean-and-the-usa-a-comparative-analysis-from-the-spanish-town-cohort-jamaica-and-the-jackson-heart-study-usa
#10
Aurelian Bidulescu, Trevor S Ferguson, Ian Hambleton, Novie Younger-Coleman, Damian Francis, Nadia Bennett, Michael Griswold, Ervin Fox, Marlene MacLeish, Rainford Wilks, E Nigel Harris, Louis W Sullivan
BACKGROUND: Studies have suggested that social inequalities in chronic disease outcomes differ between industrialized and developing countries, but few have directly compared these effects. We explored inequalities in hypertension and diabetes prevalence between African-descent populations with different levels of educational attainment in Jamaica and in the United States of America (USA), comparing disparities within each location, and between countries. METHODS: We analyzed baseline data from the Jackson Heart Study (JHS) in the USA and Spanish Town Cohort (STC) in Jamaica...
February 14, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28222386/heterogeneous-fractionation-profiles-of-meta-analytic-coactivation-networks
#11
Angela R Laird, Michael C Riedel, Mershack Okoe, Radu Jianu, Kimberly L Ray, Simon B Eickhoff, Stephen M Smith, Peter T Fox, Matthew T Sutherland
Computational cognitive neuroimaging approaches can be leveraged to characterize the hierarchical organization of distributed, functionally specialized networks in the human brain. To this end, we performed large-scale mining across the BrainMap database of coordinate-based activation locations from over 10,000 task-based experiments. Meta-analytic coactivation networks were identified by jointly applying independent component analysis (ICA) and meta-analytic connectivity modeling (MACM) across a wide range of model orders (i...
February 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28222333/immunoprofiling-as-a-predictor-of-patient-s-response-to-cancer-therapy-promises-and-challenges
#12
REVIEW
Daniel Bethmann, Zipei Feng, Bernard A Fox
Immune cell infiltration is common to many tumors and has been recognized by pathologists for more than 100 years. The application of digital imaging and objective assessment software allowed a concise determination of the type and quantity of immune cells and their location relative to the tumor and, in the case of colon cancer, characterized overall survival better than AJCC TNM staging. Subsequently, expression of PD-L1, by 50% or more tumor cells, identified NSCLC patients with double the response rate to anti-PD-1...
February 18, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28221057/-understanding-the-neural-basis-of-cognitive-bias-modification-as-a-clinical-treatment-for-depression-correction-to-eguchi-et-al-2016
#13
(no author information available yet)
: Reports an error in "Understanding the neural basis of cognitive bias modification as a clinical treatment for depression" by Akihiro Eguchi, Daniel Walters, Nele Peerenboom, Hannah Dury, Elaine Fox and Simon Stringer (Journal of Consulting and Clinical Psychology, Advanced Online Publication, Dec 19, 2016, np). In the article, there was an error in the Discussion section's first paragraph for Implications and Future Work. The in-text reference citation for Penton-Voak et al. (2013) was incorrectly listed as "Blumenfeld, Preminger, Sagi, and Tsodyks (2006)"...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28220573/a-comparison-of-two-types-of-ankle-supports-in-men-with-haemophilia-and-unilateral-ankle-pain-from-arthropathy
#14
D Oleson, L Fox, T Nguyen, P Sochacki, M McCarthy, E Adams, M Recht
INTRODUCTION: Adults with haemophilia frequently have a painful and disordered gait due to ankle arthropathy. AIM: The aim of this study was to determine if pain and gait parameters were affected by the use of different types of ankle bracing. METHODS: We investigated the gait patterns of 17 men with severe haemophilia without bracing, using a fracture boot (FB) and a carbon fibre floor reaction ankle foot orthosis (CF-AFO). Pain relief was determined in each condition...
February 20, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28219666/relation-of-iliac-artery-calcium-with-adiposity-measures-and-peripheral-artery-disease
#15
Jane J Lee, Alison Pedley, Ido Weinberg, Kathryn A Britton, Joseph M Massaro, Udo Hoffmann, Emily Manders, Caroline S Fox, Joanne M Murabito
Arterial calcification is associated with cardiovascular morbidity and mortality. To improve the understanding of the pathogenesis involved with iliac artery calcium (IAC), we sought to examine the associations between the burden of IAC with adiposity measures and peripheral artery disease (PAD). Participants (n = 1,236, 52% women, mean age 60 years) were drawn from the Framingham Heart Study Offspring cohort who underwent multidetector computed tomography. The extent of IAC was quantified based on calcified atherosclerotic plaques detected in the iliac arteries...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28218803/error-monitoring-and-empathy-explorations-within-a-neurophysiological-context
#16
Azhani Amiruddin, Simone N Fueggle, An T Nguyen, Gilles E Gignac, Karen L Clunies-Ross, Allison M Fox
Past literature has proposed that empathy consists of two components: cognitive and affective empathy. Error monitoring mechanisms indexed by the error-related negativity (ERN) have been associated with empathy. Studies have found that a larger ERN is associated with higher levels of empathy. We aimed to expand upon previous work by investigating how error monitoring relates to the independent theoretical domains of cognitive and affective empathy. Study 1 (N = 24) explored the relationship between error monitoring mechanisms and subcomponents of empathy using the Questionnaire of Cognitive and Affective Empathy and found no relationship...
February 20, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28217978/the-association-of-chronic-kidney-disease-and-microalbuminuria-with-heart-failure-with-preserved-vs-reduced-ejection-fraction
#17
Matthew Nayor, Martin G Larson, Na Wang, Rajalakshmi Santhanakrishnan, Douglas S Lee, Connie W Tsao, Susan Cheng, Emelia J Benjamin, Ramachandran S Vasan, Daniel Levy, Caroline S Fox, Jennifer E Ho
AIMS: Chronic kidney disease (CKD) and microalbuminuria are associated with incident heart failure (HF), but their relative contributions to HF with preserved vs. reduced EF (HFpEF and HFrEF) are unknown. We sought to evaluate the associations of CKD and microalbuminuria with incident HF subtypes in the community-based Framingham Heart Study (FHS). METHODS AND RESULTS: We defined CKD as glomerular filtration rate <60 mL/min/1.73 m(2) , and microalbuminuria as a urine albumin to creatinine ratio (UACR) ≥17 mg/g in men and ≥25 mg/g in women...
February 20, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28216490/-expression-and-purification-of-foxo1-dna-binding-domain-and-its-dna-properties
#18
Yinuer Ha, Jun Li, Yongheng Chen, Lin Chen, Zhuchu Chen
To express and purify FOXO1 DNA binding domain (DBD) and to evaluate its DNA binding properties.
 Methods: Gene sequence of FOXO1-DBD was optimized and the recombinant strains were induced at low temperature to obtain soluble protein of FOXO1-DBD. Then, FOXO1-DBD protein was purified through Ni affinity chromatography and cation exchange. Finally, the DNA binding properties of FOXO1-DBD was evaluated by electrophoretic mobility shift assay (EMSA).
 Results: Most of soluble proteins were obtained by optimizing its genes sequence and induction at 21 ℃...
January 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28216442/a-seven-day-course-of-trimethoprim-sulfamethoxazole-may-be-as-effective-as-a-seven-day-course-of-ciprofloxacin-for-the-treatment-of-pyelonephritis
#19
Miriam T Fox, Michael T Melia, Rebecca G Same, Anna T Conley, Pranita D Tamma
INTRODUCTION: The Infectious Diseases Society of America guidelines recommend either 14 days of trimethoprim-sulfamethoxazole (TMP-SMX) or 7 days of ciprofloxacin for the treatment of pyelonephritis. Antibiotic courses of 7 days of TMP-SMX versus 7 days of ciprofloxacin for pyelonephritis have not been previously compared. We evaluated the odds of a subsequent, symptomatic urinary tract infection (UTI) for women with E. coli pyelonephritis receiving a 7-day course of TMP-SMX versus a 7-day course of ciprofloxacin...
February 16, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28216403/investigation-of-orexin-2-selective-receptor-antagonists-structural-modifications-resulting-in-dual-orexin-receptor-antagonists
#20
Jason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, Anthony J Roecker, Joseph G Bruno, Mark A Pausch, Julie A O'Brien, Tamara D Cabalu, Joanne Stevens, Joseph Brunner, Pamela L Tannenbaum, W Peter Wuelfing, Susan L Garson, Steven V Fox, Alan T Savitz, Charles M Harrell, Anthony L Gotter, Christopher J Winrow, John J Renger, Scott D Kuduk, Paul J Coleman
In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent, OX2R-selective molecule that exhibited a promising in vivo profile. Further structural modification led to an unexpected restoration of OX1R antagonism. Herein, these changes are discussed and a rationale for selectivity based on computational modeling is proposed...
February 9, 2017: Bioorganic & Medicinal Chemistry Letters
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