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https://www.readbyqxmd.com/read/28433436/subharmonic-aided-pressure-estimation-for-monitoring-interstitial-fluid-pressure-in-tumors-calibration-and-treatment-with-paclitaxel-in-breast-cancer-xenografts
#1
Valgerdur G Halldorsdottir, Jaydev K Dave, Andrew Marshall, Anya I Forsberg, Traci B Fox, John R Eisenbrey, Priscilla Machado, Ji-Bin Liu, Daniel A Merton, Flemming Forsberg
Interstitial fluid pressure (IFP) in rats with breast cancer xenografts was non-invasively estimated using subharmonic-aided pressure estimation (SHAPE) versus an invasive pressure monitor. Moreover, monitoring of IFP changes after chemotherapy was assessed. Eighty-nine rats (calibration n = 25, treatment n = 64) were injected with 5 × 10(6) breast cancer cells (MDA-MB-231). Radiofrequency signals were acquired (39 rats successfully imaged) with a Sonix RP scanner (BK Ultrasound, Richmond, BC, Canada) using a linear array (L9-4, transmit/receive: 8/4 MHz) after administration of Definity (Lantheus Medical Imaging, North Billerica, MA, USA; 180 μL/kg) and compared with readings from an invasive pressure monitor (Stryker, Berkshire, UK)...
April 19, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28433206/efficacy-and-safety-of-rivaroxaban-versus-warfarin-in-patients-from-mainland-china-with-nonvalvular-atrial-fibrillation-a-subgroup-analysis-from-the-rocket-af-trial
#2
Yihong Sun, Dayi Hu, Susanna Stevens, Yuliya Lokhnygina, Richard C Becker, Scott D Berkowitz, Günter Breithardt, Werner Hacke, Jonathan L Halperin, Graeme J Hankey, Kenneth W Mahaffey, Christopher C Nessel, Jonathan P Piccini, Daniel E Singer, Keith A A Fox, Manesh R Patel
BACKGROUND: The ROCKET AF study evaluated once-daily rivaroxaban versus dose-adjusted warfarin for the prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). In this analysis, we compared rivaroxaban with warfarin in patients with AF from China, East Asia, and the rest of the world (ROW). METHODS AND RESULTS: We assessed baseline demographics and interaction of treatment effects of rivaroxaban versus warfarin among patients from mainland China, other East Asian countries, and ROW...
April 13, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28432592/perceptual-learning-with-tactile-stimuli-in-rodents-shaping-the-somatosensory-system
#3
REVIEW
Nicole Pacchiarini, Kevin Fox, R C Honey
The animal kingdom contains species with a wide variety of sensory systems that have been selected to function in different environmental niches, but that are also subject to modification by experience during an organism's lifetime. The modification of such systems by experience is often called perceptual learning. In rodents, the classic example of perceptual learning is the observation that simple preexposure to two visual stimuli facilitates a subsequent (reinforced) discrimination between them. However, until recently very little behavioral research had investigated perceptual learning with tactile stimuli in rodents, in marked contrast to the wealth of information about plasticity in the rodent somatosensory system...
April 21, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28431132/revealing-the-biochemical-and-genetic-basis-of-colour-variation-in-a-polymorphic-lizard
#4
Claire A McLean, Adrian Lutz, Katrina J Rankin, Devi Stuart-Fox, Adnan Moussalli
Determining the mechanistic and genetic basis of animal coloration is essential to understand the costs and constraints on colour production, and the evolution and maintenance of phenotypic variation. However, genes underlying structural colour and widespread pigment classes apart from melanin remain largely uncharacterised, in part due to restricted taxonomic focus. We combined liquid chromatography-mass spectrometry and RNA-seq gene expression analyses to characterise the pigments and genes associated with skin colour in the polymorphic lizard, Ctenophorus decresii...
April 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28430833/on-the-need-for-quantitative-bias-analysis-in-the-peer-review-process
#5
Matthew P Fox, Timothy L Lash
Peer review is central to the process through which epidemiologists generate evidence to inform public health and medical interventions. Reviewers thereby act as critical gatekeepers to high-quality research. They are asked to carefully consider the validity of the proposed work or research findings by paying careful attention to the methodology and critiquing the importance of the insight gained. However, although many have noted problems with the peer-review system for both manuscripts and grant submissions, few solutions have been proposed to improve the process...
April 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28430777/correction-the-subclonal-architecture-of-metastatic-breast-cancer-results-from-a-prospective-community-based-rapid-autopsy-program-cascade
#6
Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi
[This corrects the article DOI: 10.1371/journal.pmed.1002204.].
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28430531/phonological-development-of-danish-speaking-children-a-normative-cross-sectional-study
#7
Marit Carolin Clausen, Annette Fox-Boyer
Detailed knowledge about speech development in children acquiring different languages provides important information from a clinical and a theoretical perspective: First, it provides a baseline for the evaluation of whether a child shows typical, delayed or deviant speech development. Further, differences in speech development across languages can help to understand how the phonological systems of ambient languages affects children's speech acquisition. To date, little is known about Danish. It was suggested, however, that the acquisition process might be slower for Danish-speaking children due to the "blurry" sound structure of Danish...
April 21, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28429846/protected-engagement-time-on-older-adult-mental-health-wards-a-thematic-analysis-of-the-views-of-patients-carers-and-staff
#8
Emily Dodd, Richard Cheston, Charlie Procter, Sarah Heneker, Richard Gray, Chris Fox, Fiona Nolan
During protected engagement time (PET), ward routines are adjusted so that staff can spend time together with patients without interruption. The aim of PET is to increase staff and patient interaction on wards, and ultimately patient well-being. Although PET has been implemented on inpatient wards within the UK, including older adult wards, there is no systematic evidence as to how PET is carried out or how it is experienced by staff, patients, and families. Semistructured interviews were conducted with 28 participants (8 patients, 10 family members, and 10 ward staff) from three different wards with PET, and transcriptions were analysed using thematic analysis...
April 21, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28429728/a-formulated-tlr7-8-agonist-is-a-flexible-highly-potent-and-effective-adjuvant-for-pandemic-influenza-vaccines
#9
Neal Van Hoeven, Christopher B Fox, Brian Granger, Tara Evers, Sharvari W Joshi, Ghislain I Nana, Sarah C Evans, Susan Lin, Hong Liang, Li Liang, Rie Nakajima, Philip L Felgner, Richard A Bowen, Nicole Marlenee, Airn Hartwig, Susan L Baldwin, Rhea N Coler, Mark Tomai, James Elvecrog, Steven G Reed, Darrick Carter
Since 1997, highly pathogenic avian influenza viruses of the H5N1 subtype have been transmitted from avian hosts to humans. The severity of H5N1 infection in humans, as well as the sporadic nature of H5N1 outbreaks, both geographically and temporally, make generation of an effective vaccine a global public health priority. An effective H5N1 vaccine must ultimately provide protection against viruses from diverse clades. Toll-like receptor (TLR) agonist adjuvant formulations have a demonstrated ability to broaden H5N1 vaccine responses in pre-clinical models...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429621/the-distribution-and-movement-of-american-cockroaches-in-urban-niches-of-new-orleans
#10
John C Carlson, Felicia A Rabito, Derek Werthmann, Mark Fox
American cockroaches are an important source of household allergens in tropical and semitropical climates. To determine which outdoor niches produce American cockroaches, traps were placed at 40 homes in New Orleans to collect nymphs. Nymphs were collected from the sewers, yards, and within the homes themselves. To compare sewers and yards as sources of cockroaches entering homes, adult cockroaches were collected, marked, and released into yards and sewers. No sewer-released cockroaches were collected in homes...
April 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28428781/analysis-of-the-listeria-monocytogenes-population-structure-among-isolates-from-1931-to-2015-in-australia
#11
Amy V Jennison, Jesse J Masson, Ning-Xia Fang, Rikki M Graham, Mark I Bradbury, Narelle Fegan, Kari S Gobius, Trudy M Graham, Christine J Guglielmino, Janelle L Brown, Edward M Fox
Listeriosis remains among the most important bacterial illnesses, with a high associated mortality rate. Efforts to control listeriosis require detailed knowledge of the epidemiology of the disease itself, and its etiological bacterium, Listeria monocytogenes. In this study we provide an in-depth analysis of the epidemiology of 224 L. monocytogenes isolates from Australian clinical and non-clinical sources. Non-human sources included meat, dairy, seafood, fruit, and vegetables, along with animal and environmental isolates...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28428306/draft-nuclear-genome-sequence-of-the-liquid-hydrocarbon-accumulating-green-microalga-botryococcus-braunii-race-b-showa
#12
Daniel R Browne, Jerry Jenkins, Jeremy Schmutz, Shengqiang Shu, Kerrie Barry, Jane Grimwood, Jennifer Chiniquy, Aditi Sharma, Thomas D Niehaus, Taylor L Weiss, Andrew T Koppisch, David T Fox, Suraj Dhungana, Shigeru Okada, Joe Chappell, Timothy P Devarenne
Botryococcus braunii has long been known as a prodigious producer of liquid hydrocarbon oils that can be converted into combustion engine fuels. This draft genome for the B race of B. braunii will allow researchers to unravel important hydrocarbon biosynthetic pathways and identify possible regulatory networks controlling this unusual metabolism.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28427709/upper-limb-impairment-is-associated-with-use-of-assistive-devices-and-unemployment-in-multiple-sclerosis
#13
Ruth Ann Marrie, Gary R Cutter, Tuula Tyry, Stacey S Cofield, Robert Fox, Amber Salter
BACKGROUND: Individuals with multiple sclerosis (MS) frequently suffer from impaired sensory function, reduced strength and tremor in the upper limbs, which may interfere with upper limb function. However, upper limb impairment in MS is under-recognized and understudied. We aimed to evaluate the prevalence of upper limb impairment in a large sample of persons with MS; the association between upper limb function and employment status in MS; and the frequency of use of assistive devices aimed at addressing upper limb impairments...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28426834/acceptability-of-an-open-label-wait-listed-trial-design-experiences-from-the-proud-prep-study
#14
Mitzy Gafos, Elizabeth Brodnicki, Monica Desai, Sheena McCormack, Will Nutland, Sonali Wayal, Ellen White, Gemma Wood, Tristan Barber, Gill Bell, Amanda Clarke, David Dolling, David Dunn, Julie Fox, Lewis Haddow, Charles Lacey, Anthony Nardone, Killian Quinn, Caroline Rae, Iain Reeves, Michael Rayment, David White, Vanessa Apea, Wilbert Ayap, Claire Dewsnap, Yolanda Collaco-Moraes, Gabriel Schembri, Yinka Sowunmi, Rob Horne
BACKGROUND: PROUD participants were randomly assigned to receive pre-exposure prophylaxis (PrEP) immediately or after a deferred period of one-year. We report on the acceptability of this open-label wait-listed trial design. METHODS: Participants completed an acceptability questionnaire, which included categorical study acceptability data and free-text data on most and least liked aspects of the study. We also conducted in-depth interviews (IDI) with a purposely selected sub-sample of participants...
2017: PloS One
https://www.readbyqxmd.com/read/28423030/molecular-characterization-of-cryptosporidium-and-giardia-from-the-tasmanian-devil-sarcophilus-harrisii
#15
Liana F Wait, Samantha Fox, Sarah Peck, Michelle L Power
The Tasmanian devil (Sarcophilus harrisii) is a carnivorous marsupial found only in the wild in Tasmania, Australia. Tasmanian devils are classified as endangered and are currently threatened by devil facial tumour disease, a lethal transmissible cancer that has decimated the wild population in Tasmania. To prevent extinction of Tasmanian devils, conservation management was implemented in 2003 under the Save the Tasmanian Devil Program. This study aimed to assess if conservation management was altering the interactions between Tasmanian devils and their parasites...
2017: PloS One
https://www.readbyqxmd.com/read/28423011/the-range-of-the-mange-spatiotemporal-patterns-of-sarcoptic-mange-in-red-foxes-vulpes-vulpes-as-revealed-by-camera-trapping
#16
David Carricondo-Sanchez, Morten Odden, John D C Linnell, John Odden
Sarcoptic mange is a widely distributed disease that affects numerous mammalian species. We used camera traps to investigate the apparent prevalence and spatiotemporal dynamics of sarcoptic mange in a red fox population in southeastern Norway. We monitored red foxes for five years using 305 camera traps distributed across an 18000 km2 area. A total of 6581 fox events were examined to visually identify mange compatible lesions. We investigated factors associated with the occurrence of mange by using logistic models within a Bayesian framework, whereas the spatiotemporal dynamics of the disease were analysed with space-time scan statistics...
2017: PloS One
https://www.readbyqxmd.com/read/28422815/no-time-for-silence-an-urgent-need-for-political-activism-among-the-medical-community
#17
Erik Levinsohn, Karrin Weisenthal, Priscilla Wang, Andi Shahu, Matthew Meizlish, Talia Robledo-Gil, Eamon Duffy, Samara Fox, Juliana Berk-Krauss
Despite being a major stakeholder in the U.S. health care system, the medical community has remained relatively mute in the debate over the future of the Patient Protection and Affordable Care Act (ACA). If the ACA were repealed, tens of millions of Americans would be in danger of losing their insurance, resulting in a significant increase in mortality. Because misinformation about the ACA is rampant, it is imperative that health care providers explain to the public what exactly the ACA is and how repeal will affect patients...
April 18, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28420726/intra-and-inter-observer-reproducibility-assessment-of-pd-l1-biomarker-in-non-small-cell-lung-cancer-nsclc
#18
Wendy A Cooper, Prudence A Russell, Maya Cherian, Edwina E Duhig, David Godbolt, Peter J Jessup, Christine Khoo, Connull Leslie, Annabelle Mahar, David F Moffat, Vanathi Sivasubramaniam, Céline Faure, Alena Reznichenko, Amanda Grattan, Stephen B Fox
<br />Reliable and reproducible methods for identifying PD-L1 expression on tumor cells are necessary to identify responders to anti-PD-1 therapy. We tested the reproducibility of the assessment of PD-L1 expression in non-small cell lung cancer (NSCLC) tissue samples by pathologists.<br />Experimental Design: <br />NSCLC samples were stained with PD-L1 22C3 pharmDx™ kit using the Dako Autostainer Link 48 Platform. Two sample sets of 60 samples each were designed to assess inter- and intra-observer reproducibility considering 2 cut-points for positivity: 1% or 50% of PD-L1 stained tumor cells...
April 18, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28420323/study-protocol-insight-46-a-neuroscience-sub-study-of-the-mrc-national-survey-of-health-and-development
#19
Christopher A Lane, Thomas D Parker, Dave M Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M Jorge Cardoso, Ana Carvalho, Jessica Collins, Enrico De Vita, John C Dickson, Norah Epie, Miklos Espak, Susie M D Henley, Chandrashekar Hoskote, Michael Hutel, Jana Klimova, Ian B Malone, Pawel Markiewicz, Andrew Melbourne, Marc Modat, Anette Schrag, Sachit Shah, Nikhil Sharma, Carole H Sudre, David L Thomas, Andrew Wong, Hui Zhang, John Hardy, Henrik Zetterberg, Sebastien Ourselin, Sebastian J Crutch, Diana Kuh, Marcus Richards, Nick C Fox, Jonathan M Schott
BACKGROUND: Increasing age is the biggest risk factor for dementia, of which Alzheimer's disease is the commonest cause. The pathological changes underpinning Alzheimer's disease are thought to develop at least a decade prior to the onset of symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment - including β-amyloid depostion, vascular disease, network breakdown and atrophy - to be assessed repeatedly and non-invasively...
April 18, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28417479/accp-template-for-evaluating-a-clinical-pharmacist
#20
Mary Lee, Melissa E Badowski, Nicole M Acquisto, Douglas F Covey, Brian D Fox, Sarah M Gaffney, Stuart T Haines, Michelle L Hilaire, Alexandre Raymond, Marissa C Salvo, Kyle Turner
ACCP is committed to ensuring that clinical pharmacists possess the competencies necessary to deliver comprehensive medication management in team-based, direct patient care environments. These competencies are divided into six essential domains: direct patient care, pharmacotherapy knowledge, systems-based care and population health, communication, professionalism, and continuing professional development. The 2016 ACCP Clinical Practice Affairs Committee has developed an evaluation tool that includes the assessable tasks of today's clinical pharmacists that fall within each domain...
April 17, 2017: Pharmacotherapy
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