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Douglas Fox
No abstract text is available yet for this article.
March 20, 2018: Scientific American
Ming Zhao, Tao Liu, Feiyan Chen
Language comprehension involves pragmatic information processing, which allows world knowledge to influence the interpretation of a sentence. This study explored whether pragmatic information can be automatically processed during spoken sentence comprehension. The experiment adopted the mismatch negativity (MMN) paradigm to capture the neurophysiological indicators of automatic processing of spoken sentences. Pragmatically incorrect ('Foxes have wings') and correct ('Butterflies have wings') sentences were used as the experimental stimuli...
March 19, 2018: Neuroreport
Gerardo Martin, Carlos Yanez-Arenas, Carla Chen, Raina K Plowright, Rebecca J Webb, Lee F Skerratt
Disease risk mapping is important for predicting and mitigating impacts of bat-borne viruses, including Hendra virus (Paramyxoviridae:Henipavirus), that can spillover to domestic animals and thence to humans. We produced two models to estimate areas at potential risk of HeV spillover explained by the climatic suitability for its flying fox reservoir hosts, Pteropus alecto and P. conspicillatus. We included additional climatic variables that might affect spillover risk through other biological processes (such as bat or horse behaviour, plant phenology and bat foraging habitat)...
March 19, 2018: EcoHealth
Anthony J Mannion, Heather R Martin, Zeli Shen, Ellen M Buckley, JoAnn L Dzink-Fox, Alexis Garcia, Robert P Marini, Mary M Patterson, James G Fox
Non-human primates (NHPs) for biomedical research are commonly infected with Shigella spp. that can cause acute dysentery or chronic episodic diarrhea. These animals are often prophylactically and clinically treated with quinolone antibiotics to eradicate these possible infections. However, chromosomally- and plasmid-mediated antibiotic resistance has become an emerging concern for species in the family Enterobacteriaceae . In this study, five individual isolates of multi-drug resistant Shigella flexneri were isolated from the feces of three macaques...
2018: Frontiers in Microbiology
Jelmer Westra, Shengxian Tu, Simon Winther, Louise Nissen, Mai-Britt Vestergaard, Birgitte Krogsgaard Andersen, Emil Nielsen Holck, Camilla Fox Maule, Jane Kirk Johansen, Lene Nyhus Andreasen, Jo Krogsgaard Simonsen, Yimin Zhang, Steen Dalby Kristensen, Michael Maeng, Anne Kaltoft, Christian Juhl Terkelsen, Lars Romer Krusell, Lars Jakobsen, Johan H C Reiber, Jens Flensted Lassen, Morten Bøttcher, Hans Erik Bøtker, Evald Høj Christiansen, Niels Ramsing Holm
BACKGROUND: Quantitative flow ratio (QFR) is a novel diagnostic modality for functional testing of coronary artery stenosis without the use of pressure wires and induction of hyperemia. QFR is based on computation of standard invasive coronary angiographic imaging. The purpose of WIFI II (Wire-Free Functional Imaging II) was to evaluate the feasibility and diagnostic performance of QFR in unselected consecutive patients. METHODS AND RESULTS: WIFI II was a predefined substudy to the Dan-NICAD study (Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease), referring 362 consecutive patients with suspected coronary artery disease on coronary computed tomographic angiography for diagnostic invasive coronary angiography...
March 2018: Circulation. Cardiovascular Imaging
Graziana Da Rold, Silvia Ravagnan, Fabio Soppelsa, Elena Porcellato, Mauro Soppelsa, Federica Obber, Carlo Vittorio Citterio, Sara Carlin, Patrizia Danesi, Fabrizio Montarsi, Gioia Capelli
BACKGROUND: Northeastern Italy is a hotspot for several tick-borne pathogens, transmitted to animals and humans mainly by Ixodes ricinus. Here we compare the results of molecular monitoring of ticks and zoonotic TBPs over a six-year period, with the monitoring of red foxes (Vulpes vulpes) in an endemic area. RESULTS: In the period 2011-2016, 2,578 ticks were collected in 38 sites of 20 municipalities of Belluno Province. Individual adults (264), pooled larvae (n = 330) and nymphs (n = 1984) were screened for tick-borne encephalitis virus, Borrelia burgdorferi (s...
March 20, 2018: Parasites & Vectors
Martin O Andersson, Conny Tolf, Paula Tamba, Mircea Stefanache, Gabriel Radbea, Dimitrios Frangoulidis, Herbert Tomaso, Jonas Waldenström, Gerhard Dobler, Lidia Chitimia-Dobler
BACKGROUND: Ticks are transmitting a wide range of bacterial pathogens that cause substantial morbidity and mortality in domestic animals. The full pathogen burden transmitted by tick vectors is incompletely studied in many geographical areas, and extensive studies are required to fully understand the diversity and distribution of pathogens transmitted by ticks. RESULTS: We sampled 824 ticks of 11 species collected in 19 counties in Romania. Ticks were collected mainly from dogs, but also from other domestic and wild animals, and were subjected to molecular screening for pathogens...
March 20, 2018: Parasites & Vectors
Maayan Margalit Levi, Yaarit Nachum-Biala, Roni King, Gad Baneth
BACKGROUND: Babesia spp. and Hepatozoon spp. are apicomplexan parasites that infect a variety of animals, including canids. Their life-cycle includes an invertebrate hematophagous vector as a definitive host and vertebrates as intermediate hosts. The aims of this study were to investigate the prevalence and risk factors for Babesia spp. and Hepatozoon spp. infections in wild golden jackals (Canis aureus) and red foxes (Vulpes vulpes) in Israel and to compare spleen with blood sample polymerase chain reaction (PCR) for the detection of infection...
March 20, 2018: Parasites & Vectors
Vasudevan Bakthavatchalu, Katherine J Wert, Yan Feng, Anthony Mannion, Zhongming Ge, Alexis Garcia, Kathleen E Scott, Tyler J Caron, Carolyn M Madden, Johanne T Jacobsen, Gabriel Victora, Rudolf Jaenisch, James G Fox
Immune-compromised mouse models allow for testing the preclinical efficacy of human cell transplantations and gene therapy strategies before moving forward to clinical trials. However, CRISPR/Cas9 gene editing of the Wsh/Wsh mouse strain to create an immune-compromised model lacking function of Rag2 and Il2rγ led to unexpected morbidity and mortality. This warranted an investigation to ascertain the cause and predisposing factors associated with the outbreak. Postmortem examination was performed on 15 moribund mice...
2018: PloS One
Ricardo Carrasco-Garcia, Patricia Barroso, Javier Perez-Olivares, Vidal Montoro, Joaquín Vicente
Understanding the role that facultative scavenger species may play in spreading infectious pathogens, and even becoming reservoirs for humans, domestic and wild ungulates or, on the contrary, preventing the spread of disease, requires a prior understanding of the pattern of carrion scavenging in specific scenarios. The objectives of this paper are (i) to describe the guild of vertebrate scavengers and (ii) to study the species-specific, habitat, and management-related factors involved in the usage of gut piles in South Central Spain (SCS), a tuberculosis (TB) endemic area...
2018: Frontiers in Veterinary Science
Jinhua Wang, Wan Li, Xiangjin Zheng, Xiaocong Pang, Guanhua Du
FOXC1 is a vital member of FOX families which play important roles in biological processes including proliferation, differentiation, apoptosis, migration, invasion, metabolism, and longevity. Here we are focusing on roles of FOXC1 and their mechanisms in cancers. FOXC1 promoted progress of many cancers, such as breast cancer (especially basal-like breast cancer), hepatocellular carcinoma, gastric cancer and so on. FOXC1 was also found to be associated with drug resistance of cancers. FOXC1 promoted metastasis of cancers by increasing expression of MMP7, NEDD9 and Snail...
February 23, 2018: Oncotarget
Ida K Fox, Christine B Novak, Emily M Krauss, Gwendolyn M Hoben, Craig Zaidman, Rimma Ruvinskaya, Neringa Juknis, Anke C Winter, Susan E Mackinnon
BACKGROUND: Nerve transfer surgery to restore upper extremity (UE) function in cervical spinal cord injury (SCI) is novel and may transform treatment. Determining candidacy even years post-SCI is ill-defined and deserves investigation. OBJECTIVE: To develop a diagnostic algorithm, focusing on electrodiagnostic studies (EDX), to determine eligibility for nerve transfer surgery. DESIGN: Retrospective descriptive case series SETTING: Tertiary university-based institution PATIENTS: Individuals with cervical SCI (n = 45) METHODS: The electronic medical records of people referred to the Plastic and Reconstructive Surgery UE Surgery in SCI clinic from 2010-2015 were reviewed...
March 15, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Anne-Marie Burn, Jane Fleming, Carol Brayne, Chris Fox, Frances Bunn
OBJECTIVES: In 2012-2013, the English National Health Service mandated hospitals to conduct systematic case-finding of people with dementia among older people with unplanned admissions. The method was not defined. The aim of this study was to understand current approaches to dementia case-finding in acute hospitals in England and explore the views of healthcare professionals on perceived benefits and challenges. DESIGN: Qualitative study involving interviews, focus groups and thematic content analysis...
March 17, 2018: BMJ Open
Katie A Hunt, Yosuke Yamada, Vadivelam Murthy, Prashanth Srihari Bhat, Morag Campbell, Grenville F Fox, Anthony D Milner, Anne Greenough
OBJECTIVES: End tidal carbon dioxide (ETCO2 ) monitoring can facilitate identification of successful intubation. The aims of this study were to determine the time to detect ETCO2 following intubation during resuscitation of infants born prematurely and whether it differed according to maturity at birth or the Apgar scores (as a measure of the infant's condition after birth). DESIGN: Analysis of recordings of respiratory function monitoring. SETTING: Two tertiary perinatal centres...
March 17, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Lindsay M Fox, Mikiko Murakami, Houman Danesh, Alex F Manini
INTRODUCTION: Battlefield acupuncture (BFA) is an ear acupuncture protocol used by the military for immediate pain relief. This is a pilot feasibility study of BFA as a treatment for acute low back pain (LBP) in the emergency department (ED). METHODS: Thirty acute LBP patients that presented to ED were randomized to standard care plus BFA or standard care alone. In the BFA group, outcomes were assessed at the time of randomization, 5 min after intervention, and again within 1 h after intervention...
February 27, 2018: American Journal of Emergency Medicine
Mathieu Kerneis, C Michael Gibson, Gerald Chi, Roxana Mehran, Fahad AlKhalfan, Usama Talib, Seyedmahdi Pahlavani, Mahshid Mir, Christoph Bode, Jonathan L Halperin, Tarek Nafee, Eric D Peterson, Freek W A Verheugt, Peter Wildgoose, Martin van Eickels, Gregory Y H Lip, Keith A A Fox, Marc Cohen
OBJECTIVES: This study sought to assess whether there were significant interactions of procedural access strategies and lesion characteristics with bleeding and ischemic events among atrial fibrillation (AF) patients anticoagulated with rivaroxaban or warfarin following a percutaneous coronary intervention. BACKGROUND: Among stented AF patients, the impact of procedural access strategies or lesion characteristics on antithrombotic safety and efficacy outcomes is unclear...
March 8, 2018: JACC. Cardiovascular Interventions
Allison M Cummins, Rachel Smith, Christine Catling, Nicole Watts, Vanessa Scarf, Deborah Fox, Joanne Gray
No abstract text is available yet for this article.
February 22, 2018: Midwifery
Mel O'Leary, Daria Boscolo, Nicole Breslin, Jeremy M C Brown, Igor P Dolbnya, Chris Emerson, Catarina Figueira, Oliver J L Fox, David Robert Grimes, Vladimir Ivosev, Annette K Kleppe, Aaron McCulloch, Ian Pape, Chris Polin, Nathan Wardlow, Fred J Currell
Absolute measurements of the radiolytic yield of Fe3+ in a ferrous sulphate dosimeter formulation (6 mM Fe2+), with a 20 keV x-ray monoenergetic beam, are reported. Dose-rate suppression of the radiolytic yield was observed at dose rates lower than and different in nature to those previously reported with x-rays. We present evidence that this effect is most likely to be due to recombination of free radicals radiolytically produced from water. The method used to make these measurements is also new and it provides radiolytic yields which are directly traceable to the SI standards system...
March 16, 2018: Scientific Reports
Sylvia R Kodsi, Sara L Bristow, Joyce E Fox, Avner Hershlag
Preimplantation genetic diagnosis can allow a family with a hereditary genetic mutation to conceive a disease-free child. We report the first published case of a child born without Leber congenital amaurosis through preimplantation genetic testing to a couple who had a son with a homozygous mutation in the GUCY2D gene.
March 13, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Matt DeLisi, Bryanna H Fox, Matthew Fully, Michael G Vaughn
Recent interest among criminologists on the construct of temperament has been fueled by DeLisi and Vaughn's (2014) temperament-based theory of antisocial behavior. Their theory suggests that core self-regulation capacity and negative emotionality are the most salient temperament features for understanding the emergence and maintenance of antisocial and violent behavior, even among offending populations. The present study tests the relative effects of these temperamental features along with psychopathic traits and trauma in their association with violent and non-violent delinquency in a sample of 252 juvenile offenders...
March 2018: International Journal of Law and Psychiatry
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