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eccentric overload

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https://www.readbyqxmd.com/read/29931050/a-gene-therapeutic-approach-to-inhibit-cib1-ameliorates-maladaptive-remodeling-in-pressure-overload
#1
Andrea Grund, Malgorzata Szaroszyk, Janina K Döppner, Mona Malek Mohammadi, Badder Kattih, Mortimer Korf-Klingebiel, Anna Gigina, Michaela Scherr, George Kensah, Monica Jara-Avaca, Ina Gruh, Ulrich Martin, Kai C Wollert, Antje Gohla, Hugo A Katus, Oliver J Müller, Johann Bauersachs, Joerg Heineke
Aims: Chronic heart failure is becoming increasingly prevalent and is still associated with a high mortality rate. Myocardial hypertrophy and fibrosis drive cardiac remodeling and heart failure, but they are not sufficiently inhibited by current treatment strategies. Furthermore, despite increasing knowledge on cardiomyocyte intracellular signaling proteins inducing pathological hypertrophy, therapeutic approaches to target these molecules are currently unavailable. In this study, we aimed to establish and test a therapeutic tool to counteract the 22kDa calcium and integrin binding protein (CIB) 1, which we have previously identified as nodal regulator of pathological cardiac hypertrophy and as activator of the maladaptive calcineurin/NFAT axis...
June 20, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29927889/accentuated-eccentric-loading-and-cluster-set-configurations-in-the-back-squat-a-kinetic-and-kinematic-analysis
#2
John P Wagle, Aaron J Cunanan, Kevin M Carroll, Matt L Sams, Alexander Wetmore, Garett E Bingham, Christopher B Taber, Brad H DeWeese, Kimitake Sato, Charles A Stuart, Michael H Stone
Wagle, JP, Cunanan, AJ, Carroll, KM, Sams, ML, Wetmore, A, Bingham, GE, Taber, CB, DeWeese, BH, Sato, K, Stuart, CA, and Stone, MH. Accentuated eccentric loading and cluster set configurations in the back squat: a kinetic and kinematic analysis. J Strength Cond Res XX(X): 000-000, 2018-This study examined the kinetic and kinematic differences between accentuated eccentric loading (AEL) and cluster sets in trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, and back squat to body mass ratio = 1...
June 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29873876/can-myocardial-remodeling-be-a-useful-surrogate-predictor-of-myocardial-iron-load-a-3d-echocardiographic-multicentric-study
#3
H M Agha, A F AbdelMassih, M Y AbdelRahman, O Milanesi, B Castaldi, G Geranio, M C Putti, A Kharabish, R Esmail, G El-Kamah, M Hamdy, H El-Baz, N El-Behary, C Hanna, H El-Tagy, M A Mishriky, M Mamdouh, A Livio, T Ramadan
The relationship between myocardial iron load and eccentric myocardial remodeling remains an under-investigated area; it was thought that remodeling is rather linked to fibrosis. This study aims to determine whether or not measures of remodeling can be used as predictors of myocardial iron. For this purpose, 60 patients with thalassemia were studied with 3D echocardiography and myocardial relaxometry (T2*) by Cardiac MRI. 3D derived sphericity index was significantly higher in patients with myocardial iron load...
June 6, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29799277/pressure-volume-analysis-reveals-characteristic-sex-related-differences-in-cardiac-function-in-a-rat-model-of-aortic-banding-induced-myocardial-hypertrophy
#4
Mihály Ruppert, Sevil Korkmaz-Icöz, Sivakkanan Loganathan, Weipeng Jiang, Lorenz H Lehmann, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Matthias Karck, Tamás Radovits, Gábor Szabó
Sex differences in pressure overload (PO)-induced left ventricular (LV) myocardial hypertrophy (LVH) have been intensely investigated. Nevertheless, sex-related disparities of LV hemodynamics in LVH were not examined in detail. Therefore, we aimed to provide a detailed characterization of distinct aspects of LV function in male and female rats during different stages of LVH. Banding of the abdominal aorta (AB) was performed to induce PO for 6 or 12 weeks in male and female rats. Control animals underwent sham operation...
May 25, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29663506/new-classification-of-geometric-ventricular-patterns-in-severe-aortic-stenosis-could-it-be-clinically-useful
#5
Concetta Di Nora, Eugenio Cervesato, Iulian Cosei, Andreea Ravasel, Bogdan A Popescu, Concetta Zito, Scipione Carerj, Francesco Antonini-Canterin, Andreea C Popescu
BACKGROUND: In severe aortic stenosis, different left ventricle (LV) remodeling patterns as a response to pressure overload have distinct hemodynamic profiles, cardiac function, and outcomes. The most common classification considers LV relative wall thickness and LV mass index to create 4 different groups. A new classification including also end-diastolic volume index has been recently proposed. AIM: To describe the prevalence of the newly identified remodeling patterns in patients with severe aortic stenosis and to evaluate their clinical relevance according to symptoms...
April 16, 2018: Echocardiography
https://www.readbyqxmd.com/read/29663488/delayed-onset-muscle-soreness-in-human-masticatory-muscles-increases-inhibitory-jaw-reflex-responses
#6
M Koutris, K S Türker, M K A van Selms, F Lobbezoo
The effects of masticatory muscles' overloading on jaw-motor control are not yet fully clarified. Therefore, it was tested whether eccentric and concentric exercises of the human masticatory muscles would influence inhibitory jaw reflex responses. Eleven participants (6 males, 5 females) performed 6, 5-minutes bouts of eccentric-concentric contractions. Before, immediately after, 24 hours, 48 hours and 1 week afterwards, visual analogue scale (VAS) scores for jaw muscle fatigue and pain, maximum voluntary bite force (MVBF) and inhibitory jaw reflexes were recorded...
June 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29590139/the-effects-of-unilateral-and-bilateral-eccentric-overload-training-on-hypertrophy-muscle-power-and-cod-performance-and-its-determinants-in-team-sport-players
#7
Francisco Javier Núñez, Alfredo Santalla, Irene Carrasquila, Jose Antonio Asian, Jose Ignacio Reina, Luis Jesús Suarez-Arrones
The study aimed to compare the chronic eccentric-overload training effects of unilateral (lateral lunge) vs bilateral (half-squat) using an inertial device, on hypertrophy and physical performance. Twenty-seven young team sports male players performed a 4 sets of 7 repetitions of inertial eccentric overload training, biweekly for 6 weeks, distributed in unilateral lunge group (UG: age: 22.8 ± 2.9 years; body mass: 75.3 ± 8.8 kg; height: 177.3 ± 3.7 cm) and bilateral squat group (BG: age: 22.6 ± 2.7 years; body mass: 79...
2018: PloS One
https://www.readbyqxmd.com/read/29558854/characterising-overload-in-inertial-flywheel-devices-for-use-in-exercise-training
#8
Kevin M Carroll, John P Wagle, Kimitake Sato, Christopher B Taber, Nobuhisa Yoshida, Garett E Bingham, Michael H Stone
The purposes of this investigation were to: (1) assess kinetic characteristics of overload, (2) examine eccentric and concentric muscle activations and (3) explore velocity measurement as a method of intensity prescription in inertial flywheel squat training. A series of two experiments were performed: one assessing kinetic and muscle activation characteristics of flywheel squat training using three progressive inertial loads. The second experiment assessed inertial load-velocity relationships using six progressive inertial loads...
March 21, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29518761/hormonal-responses-following-eccentric-exercise-in-humans
#9
Anastassios Philippou, Maria Maridaki, Roxane Tenta, Michael Koutsilieris
OBJECTIVE: Mechanically overloaded muscle and its subsequent damage are strong stimuli for eliciting acute hormonal changes, while the muscle adaptation which occurs following exercise-induced muscle damage may involve complex hormonal responses before the completion of muscle regeneration. The purpose of this study was to investigate systemic responses of various hormones, as well as secreted proteins that are exercise-regulated and associated with muscle adaptation, for several days after eccentric exercise-induced muscle damage in humans...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29389836/strength-training-effects-on-muscular-regeneration-after-acl-reconstruction
#10
Birgit Friedmann-Bette, Francesca Profit, Thomas Gwechenberger, Nadine Weiberg, Mario Parstorfer, Marc-Andre Weber, Nikolaus Streich, Alexander Barié
PURPOSE: Protracted quadriceps muscle atrophy is observed after anterior cruciate ligament reconstruction (ACL-R). The aim of this study was to assess if quadriceps strength training with eccentric overload (CON/ECC) is more efficient to induce muscle regeneration after ACL-R than conventional concentric/eccentric (CON/ECC) strength training. METHODS: Biopsies from the vastus lateralis muscle were obtained from 37 recreational athletes after 12 weeks of regular rehabilitation following ACL-R and again after 12 weeks with twice a week either conventional CON/ECC (n = 16) or CON/ECC (n = 21) one-legged supervised leg-press training...
January 31, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29339993/functional-and-muscle-size-effects-of-flywheel-resistance-training-with-eccentric-overload-in-professional-handball-players
#11
Sergio Maroto-Izquierdo, David García-López, José A de Paz
The aim of the study was to analyse the effects of 6 week (15 sessions) flywheel resistance training with eccentric-overload (FRTEO) on different functional and anatomical variables in professional handball players. Twenty-nine athletes were recruited and randomly divided into two groups. The experimental group (EXP, n = 15) carried out 15 sessions of FRTEO in the leg-press exercise, with 4 sets of 7 repetitions at a maximum-concentric effort. The control group (CON, n = 14) performed the same number of training sessions including 4 sets of 7 maximum repetitions (7RM) using a weight-stack leg-press machine...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29283475/the-importance-of-integrated-left-atrial-evaluation-from-hypertension-to-heart-failure-with-preserved-ejection-fraction
#12
REVIEW
Matteo Beltrami, Alberto Palazzuoli, Luigi Padeletti, Elisabetta Cerbai, Stefano Coiro, Michele Emdin, Rossella Marcucci, Doralisa Morrone, Matteo Cameli, Ketty Savino, Roberto Pedrinelli, Giuseppe Ambrosio
AIM: Functional analysis and measurement of left atrium are an integral part of cardiac evaluation, and they represent a key element during non-invasive analysis of diastolic function in patients with hypertension (HT) and/or heart failure with preserved ejection fraction (HFpEF). However, diastolic dysfunction remains quite elusive regarding classification, and atrial size and function are two key factors for left ventricular (LV) filling evaluation. Chronic left atrial (LA) remodelling is the final step of chronic intra-cavitary pressure overload, and it accompanies increased neurohormonal, proarrhythmic and prothrombotic activities...
February 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29196344/differential-cardiac-hypertrophy-and-signaling-pathways-in-pressure-versus-volume-overload
#13
Jieyun You, Jian Wu, Qi Zhang, Yong Ye, Shijun Wang, Jiayuan Huang, Haibo Liu, Xiaoyan Wang, Weijing Zhang, Liping Bu, Jiming Li, Li Lin, Junbo Ge, Yunzeng Zou
Mechanical overload can be classified into pressure overload and volume overload, causing concentric and eccentric cardiac hypertrophy, respectively. Here, we aimed to differentiate the load-mediated signaling pathways involved in pressure versus volume overload cardiac hypertrophy. Pressure or volume overload was imposed on C57BL/6J mice by transverse aortic constriction (TAC) or aortic regurgitation (AR), respectively. After surgery (2 wk), left ventricular structure and function were evaluated by echocardiographic, hemodynamic, and histological analyses...
March 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29182431/impact-induced-muscle-damage-and-contact-sport-aetiology-effects-on-neuromuscular-function-and-recovery-and-the-modulating-effects-of-adaptation-and-recovery-strategies
#14
Mitchell Naughton, Joanna Miller, Gary J Slater
Athletes involved in contact-sports are habitually exposed to skeletal muscle damage as part of their training and performance environments. This often leads to exercise-induced muscle damage (EIMD) resulting from repeated eccentric and/or high-intensity exercise, and impact-induced muscle damage (IIMD) resulting from collisions with opponents and the playing surface. Whilst EIMD has been an area of extensive investigation, IIMD has received comparatively little research, with the magnitude and timeframe of alterations following IIMD not presently well understood...
November 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29081259/brain-activation-associated-with-eccentric-movement-a-narrative-review-of-the-literature
#15
Stéphane Perrey
The movement occurring when a muscle exerts tension while lengthening is known as eccentric muscle action. Literature contains limited evidence on how our brain controls eccentric movement. However, how the cortical regions in the motor network are activated during eccentric muscle actions may be critical for understanding the underlying control mechanism of eccentric movements encountered in daily tasks. This is a novel topic that has only recently begun to be investigated through advancements in neuroimaging methods (electroencephalography, EEG; functional magnetic resonance imaging, fMRI)...
February 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29068866/does-flywheel-paradigm-training-improve-muscle-volume-and-force-a-meta-analysis
#16
Francisco J Nuñez Sanchez, Eduardo Sáez de Villarreal
Núñez Sanchez, FJ and Sáez de Villarreal, E. Does flywheel paradigm training improve muscle volume and force? A meta-analysis. J Strength Cond Res 31(11): 3177-3186, 2017-Several studies have confirmed the efficacy of flywheel paradigm training for improving or benefiting muscle volume and force. A meta-analysis of 13 studies with a total of 18 effect sizes was performed to analyse the role of various factors on the effectiveness of flywheel paradigm training. The following inclusion criteria were employed for the analysis: (a) randomized studies; (b) high validity and reliability instruments; (c) published in a high quality peer-reviewed journal; (d) healthy participants; (e) studies where the eccentric programme were described; and (f) studies where increases in muscle volume and force were measured before and after training...
November 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28888840/teneligliptin-prevents-cardiomyocyte-hypertrophy-fibrosis-and-development-of-hypertensive-heart-failure-in-dahl-salt-sensitive-rats
#17
Masayoshi Yamamoto, Tomoko Ishizu, Yoshihiro Seo, Yoshimi Suto, Seika Sai, Dongzhu Xu, Nobuyuki Murakoshi, Taizo Kimura, Yasushi Kawakami, Kazutaka Aonuma
BACKGROUND: We investigated the effects of the dipeptidyl peptidase 4 inhibitor teneligliptin on cardiac function and hemodynamics during heart failure in hypertensive model rats. METHODS AND RESULTS: Fifty-five male Dahl salt-sensitive rats were divided into 4 groups: control group (0.3% NaCl chow; n = 13), hypertension (HT) group (8% NaCl chow; n = 20), HT-early TNL group (8% NaCl chow and teneligliptin from 6 weeks; n = 10), and HT-late TNL group (8% NaCl chow and teneligliptin from 10 weeks; n = 12)...
January 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28885350/usefulness-of-three-dimensional-spherical-index-to-assess-different-types-of-left-ventricular-remodeling-a-meta-analysis
#18
Decai Zeng, Hui Chen, Chun Lan Jiang, Ji Wu
BACKGROUND: Left ventricular (LV) remodeling after myocardial injury, volume or pressure overload is characterized by a change in LV shape from an ellipse to more of a sphere. The usefulness of 3-dimensional (3D) sphericity index (SpI) for accurate evaluation of LV remodeling remains uncertain despite extensive research. METHODS: We searched Pubmed, Embase, Web of Science, and Cochrane databases to identify relevant studies from January 1, 1990 to August 1, 2016...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28872379/influence-of-different-inertial-loads-on-basic-training-variables-during-the-flywheel-squat-exercise
#19
Rafael Sabido, Jose Luis Hernández-Davó, Gabriel T Pereyra-Gerber
PURPOSE: This study aimed to analyse the effects of different inertial loads on power production and power maintenance), as well as the number of sessions required for proper familiarization during the flywheel quarter-squat. METHODS: Twenty-four high-level handball players attended four testing sessions consisting of 4 sets of 10 repetitions using 4 different inertial loads (0.025, 0.050, 0.075 and 0.100 kg·m2). In addition, a fifth set of 15 repetitions was performed...
September 5, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28738671/inertial-flywheel-resistance-training-and-muscle-oxygen-saturation
#20
Rafael Timón, Jesús G Ponce-González, José L González-Montesinos, Guillermo Olcina, Alejandro Pérez-Pérez, José Castro-Piñero
BACKGROUND: The inertial flywheel device causes an increase in eccentric overload during training. The aim was to study muscle oxygen saturation produced during an inertial flywheel squat training, comparing it with a barbell squat training. METHODS: Twelve male adults performed a barbell squat training (3 x 8 reps, 75-80% 1RM) and a flywheel squat training (3 x 8 reps, all-out). Muscle oxygen saturation (%SmO2), total hemoglobin (tHb), reoxygenation, heart rate (HR), lactate, vertical jumps, maximal voluntary isometric contraction and rated perceived exertion (RPE) were studied...
July 24, 2017: Journal of Sports Medicine and Physical Fitness
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