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https://www.readbyqxmd.com/read/27910389/overview-of-diagnostic-performance-and-results-for-the-first-operation-phase-in-wendelstein-7-x-invited
#1
M Krychowiak, A Adnan, A Alonso, T Andreeva, J Baldzuhn, T Barbui, M Beurskens, W Biel, C Biedermann, B D Blackwell, H S Bosch, S Bozhenkov, R Brakel, T Bräuer, B Brotas de Carvalho, R Burhenn, B Buttenschön, A Cappa, G Cseh, A Czarnecka, A Dinklage, P Drews, A Dzikowicka, F Effenberg, M Endler, V Erckmann, T Estrada, O Ford, T Fornal, H Frerichs, G Fuchert, J Geiger, O Grulke, J H Harris, H J Hartfuß, D Hartmann, D Hathiramani, M Hirsch, U Höfel, S Jabłoński, M W Jakubowski, J Kaczmarczyk, T Klinger, S Klose, J Knauer, G Kocsis, R König, P Kornejew, A Krämer-Flecken, N Krawczyk, T Kremeyer, I Książek, M Kubkowska, A Langenberg, H P Laqua, M Laux, S Lazerson, Y Liang, S C Liu, A Lorenz, A O Marchuk, S Marsen, V Moncada, D Naujoks, H Neilson, O Neubauer, U Neuner, H Niemann, J W Oosterbeek, M Otte, N Pablant, E Pasch, T Sunn Pedersen, F Pisano, K Rahbarnia, L Ryć, O Schmitz, S Schmuck, W Schneider, T Schröder, H Schuhmacher, B Schweer, B Standley, T Stange, L Stephey, J Svensson, T Szabolics, T Szepesi, H Thomsen, J-M Travere, H Trimino Mora, H Tsuchiya, G M Weir, U Wenzel, A Werner, B Wiegel, T Windisch, R Wolf, G A Wurden, D Zhang, A Zimbal, S Zoletnik
Wendelstein 7-X, a superconducting optimized stellarator built in Greifswald/Germany, started its first plasmas with the last closed flux surface (LCFS) defined by 5 uncooled graphite limiters in December 2015. At the end of the 10 weeks long experimental campaign (OP1.1) more than 20 independent diagnostic systems were in operation, allowing detailed studies of many interesting plasma phenomena. For example, fast neutral gas manometers supported by video cameras (including one fast-frame camera with frame rates of tens of kHz) as well as visible cameras with different interference filters, with field of views covering all ten half-modules of the stellarator, discovered a MARFE-like radiation zone on the inboard side of machine module 4...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27867310/the-north-wyke-farm-platform-effect-of-temperate-grassland-farming-systems-on-soil-moisture-contents-runoff-and-associated-water-quality-dynamics
#2
R J Orr, P J Murray, C J Eyles, M S A Blackwell, L M Cardenas, A L Collins, J A J Dungait, K W T Goulding, B A Griffith, S J Gurr, P Harris, J M B Hawkins, T H Misselbrook, C Rawlings, A Shepherd, H Sint, T Takahashi, K N Tozer, A P Whitmore, L Wu, M R F Lee
: The North Wyke Farm Platform was established as a United Kingdom national capability for collaborative research, training and knowledge exchange in agro-environmental sciences. Its remit is to research agricultural productivity and ecosystem responses to different management practices for beef and sheep production in lowland grasslands. A system based on permanent pasture was implemented on three 21-ha farmlets to obtain baseline data on hydrology, nutrient cycling and productivity for 2 years...
July 2016: European Journal of Soil Science
https://www.readbyqxmd.com/read/27768338/h-e-s-s-limits-on-linelike-dark-matter-signatures-in-the-100%C3%A2-gev-to-2%C3%A2-tev-energy-range-close-to-the-galactic-center
#3
H Abdalla, A Abramowski, F Aharonian, F Ait Benkhali, A G Akhperjanian, T Andersson, E O Angüner, M Arrieta, P Aubert, M Backes, A Balzer, M Barnard, Y Becherini, J Becker Tjus, D Berge, S Bernhard, K Bernlöhr, E Birsin, R Blackwell, M Böttcher, C Boisson, J Bolmont, P Bordas, J Bregeon, F Brun, P Brun, M Bryan, T Bulik, M Capasso, J Carr, S Casanova, N Chakraborty, R Chalme-Calvet, R C G Chaves, A Chen, J Chevalier, M Chrétien, S Colafrancesco, G Cologna, B Condon, J Conrad, C Couturier, Y Cui, I D Davids, B Degrange, C Deil, J Devin, P deWilt, A Djannati-Ataï, W Domainko, A Donath, L O'C Drury, G Dubus, K Dutson, J Dyks, M Dyrda, T Edwards, K Egberts, P Eger, J-P Ernenwein, S Eschbach, C Farnier, S Fegan, M V Fernandes, A Fiasson, G Fontaine, A Förster, S Funk, M Füßling, S Gabici, M Gajdus, Y A Gallant, T Garrigoux, G Giavitto, B Giebels, J F Glicenstein, D Gottschall, A Goyal, M-H Grondin, M Grudzińska, D Hadasch, J Hahn, J Hawkes, G Heinzelmann, G Henri, G Hermann, O Hervet, A Hillert, J A Hinton, W Hofmann, C Hoischen, M Holler, D Horns, A Ivascenko, A Jacholkowska, M Jamrozy, M Janiak, D Jankowsky, F Jankowsky, M Jingo, T Jogler, L Jouvin, I Jung-Richardt, M A Kastendieck, K Katarzyński, U Katz, D Kerszberg, B Khélifi, M Kieffer, J King, S Klepser, D Klochkov, W Kluźniak, D Kolitzus, Nu Komin, K Kosack, S Krakau, M Kraus, F Krayzel, P P Krüger, H Laffon, G Lamanna, J Lau, J-P Lees, J Lefaucheur, V Lefranc, A Lemière, M Lemoine-Goumard, J-P Lenain, E Leser, R Liu, T Lohse, M Lorentz, I Lypova, V Marandon, A Marcowith, C Mariaud, R Marx, G Maurin, N Maxted, M Mayer, P J Meintjes, M Meyer, A M W Mitchell, R Moderski, M Mohamed, K Morå, E Moulin, T Murach, M de Naurois, F Niederwanger, J Niemiec, L Oakes, P O'Brien, H Odaka, S Ohm, M Ostrowski, S Öttl, I Oya, M Padovani, M Panter, R D Parsons, M Paz Arribas, N W Pekeur, G Pelletier, C Perennes, P-O Petrucci, B Peyaud, S Pita, H Poon, D Prokhorov, H Prokoph, G Pühlhofer, M Punch, A Quirrenbach, S Raab, A Reimer, O Reimer, M Renaud, R de Los Reyes, F Rieger, C Romoli, S Rosier-Lees, G Rowell, B Rudak, C B Rulten, V Sahakian, D Salek, D A Sanchez, A Santangelo, M Sasaki, R Schlickeiser, F Schüssler, A Schulz, U Schwanke, S Schwemmer, M Settimo, A S Seyffert, N Shafi, I Shilon, R Simoni, H Sol, F Spanier, G Spengler, F Spies, Ł Stawarz, R Steenkamp, C Stegmann, F Stinzing, K Stycz, I Sushch, J-P Tavernet, T Tavernier, A M Taylor, R Terrier, L Tibaldo, M Tluczykont, C Trichard, R Tuffs, J van der Walt, C van Eldik, B van Soelen, G Vasileiadis, J Veh, C Venter, A Viana, P Vincent, J Vink, F Voisin, H J Völk, T Vuillaume, Z Wadiasingh, S J Wagner, P Wagner, R M Wagner, R White, A Wierzcholska, P Willmann, A Wörnlein, D Wouters, R Yang, V Zabalza, D Zaborov, M Zacharias, A A Zdziarski, A Zech, F Zefi, A Ziegler, N Żywucka
: A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l=-1...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27740645/frequency-of-root-surface-microgrooves-associated-with-periodontal-destruction
#4
Stephen K Harrel, Pillar Valderrama, James B Barnes, Evan L Blackwell
Small linear microgrooves have been observed on root surfaces associated with osseous defects when videoscope-assisted minimally invasive surgery (V-MIS) is performed. The aim of this study was to evaluate the frequency of occurrence of these microgrooves associated with osseous defects. Videos of dry skulls from an anatomy department collection and videos made during consecutive V-MIS procedures on patients were evaluated to determine the presence or absence of microgrooves associated with osseous defects...
November 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27700099/organic-acids-regulation-of-chemical-microbial-phosphorus-transformations-in-soils
#5
Daniel Menezes-Blackburn, Cecilia Paredes, Hao Zhang, Courtney D Giles, Tegan Darch, Marc Stutter, Timothy S George, Charles Shand, David Lumsdon, Patricia Cooper, Renate Wendler, Lawrie Brown, Martin Blackwell, Catherine Wearing, Philip M Haygarth
We have used an integrated approach to study the mobility of inorganic phosphorus (P) from soil solid phase as well as the microbial biomass P and respiration at increasing doses of citric and oxalic acid in two different soils with contrasting agronomic P status. Citric or oxalic acids significantly increased soil solution P concentrations for doses over 2 mmol kg-1. However, low organic acid doses (<2 mmol kg-1) were associated with a steep increase in microbial biomass P, which was not seen for higher doses...
October 4, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27683396/shell-we-date-esr-dating-sangamon-interglacial-episode-deposits-at-hopwood-farm-il
#6
Bonnie A B Blackwell, Danny M K Kim, B Brandon Curry, David A Grimley, Joel I B Blickstein, Anne R Skinner
During the Sangamon Episode, North America occasionally experienced warm climates. At Hopwood Farm, IL, a small kettle lake filled with sediment after the Illinois Episode glaciers retreated from southern Illinois. To date those deposits, 14 mollusc samples newly collected with associated sediment from three depths at Hopwood Farm were dated by standard electron spin resonance (ESR) dating. ESR can date molluscs from ~0.5 ka to >2 Ma in age with 5-10% precision, by comparing the accumulated radiation dose with the total radiation dose rate from the mollusc and its environment...
September 28, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27661677/search-for-dark-matter-annihilations-towards-the-inner-galactic-halo-from-10-years-of-observations-with-h-e-s-s
#7
H Abdallah, A Abramowski, F Aharonian, F Ait Benkhali, A G Akhperjanian, E Angüner, M Arrieta, P Aubert, M Backes, A Balzer, M Barnard, Y Becherini, J Becker Tjus, D Berge, S Bernhard, K Bernlöhr, E Birsin, R Blackwell, M Böttcher, C Boisson, J Bolmont, P Bordas, J Bregeon, F Brun, P Brun, M Bryan, T Bulik, M Capasso, J Carr, S Casanova, N Chakraborty, R Chalme-Calvet, R C G Chaves, A Chen, J Chevalier, M Chrétien, S Colafrancesco, G Cologna, B Condon, J Conrad, C Couturier, Y Cui, I D Davids, B Degrange, C Deil, P deWilt, A Djannati-Ataï, W Domainko, A Donath, L O'C Drury, G Dubus, K Dutson, J Dyks, M Dyrda, T Edwards, K Egberts, P Eger, J-P Ernenwein, S Eschbach, C Farnier, S Fegan, M V Fernandes, A Fiasson, G Fontaine, A Förster, S Funk, M Füßling, S Gabici, M Gajdus, Y A Gallant, T Garrigoux, G Giavitto, B Giebels, J F Glicenstein, D Gottschall, A Goyal, M-H Grondin, M Grudzińska, D Hadasch, J Hahn, J Hawkes, G Heinzelmann, G Henri, G Hermann, O Hervet, A Hillert, J A Hinton, W Hofmann, C Hoischen, M Holler, D Horns, A Ivascenko, A Jacholkowska, M Jamrozy, M Janiak, D Jankowsky, F Jankowsky, M Jingo, T Jogler, L Jouvin, I Jung-Richardt, M A Kastendieck, K Katarzyński, U Katz, D Kerszberg, B Khélifi, M Kieffer, J King, S Klepser, D Klochkov, W Kluźniak, D Kolitzus, Nu Komin, K Kosack, S Krakau, M Kraus, F Krayzel, P P Krüger, H Laffon, G Lamanna, J Lau, J-P Lees, J Lefaucheur, V Lefranc, A Lemière, M Lemoine-Goumard, J-P Lenain, E Leser, T Lohse, M Lorentz, R Lui, I Lypova, V Marandon, A Marcowith, C Mariaud, R Marx, G Maurin, N Maxted, M Mayer, P J Meintjes, U Menzler, M Meyer, A M W Mitchell, R Moderski, M Mohamed, K Morå, E Moulin, T Murach, M de Naurois, F Niederwanger, J Niemiec, L Oakes, H Odaka, S Ohm, S Öttl, M Ostrowski, I Oya, M Padovani, M Panter, R D Parsons, M Paz Arribas, N W Pekeur, G Pelletier, P-O Petrucci, B Peyaud, S Pita, H Poon, D Prokhorov, H Prokoph, G Pühlhofer, M Punch, A Quirrenbach, S Raab, A Reimer, O Reimer, M Renaud, R de Los Reyes, F Rieger, C Romoli, S Rosier-Lees, G Rowell, B Rudak, C B Rulten, V Sahakian, D Salek, D A Sanchez, A Santangelo, M Sasaki, R Schlickeiser, F Schüssler, A Schulz, U Schwanke, S Schwemmer, A S Seyffert, N Shafi, R Simoni, H Sol, F Spanier, G Spengler, F Spieß, L Stawarz, R Steenkamp, C Stegmann, F Stinzing, K Stycz, I Sushch, J-P Tavernet, T Tavernier, A M Taylor, R Terrier, M Tluczykont, C Trichard, R Tuffs, J van der Walt, C van Eldik, B van Soelen, G Vasileiadis, J Veh, C Venter, A Viana, P Vincent, J Vink, F Voisin, H J Völk, T Vuillaume, Z Wadiasingh, S J Wagner, P Wagner, R M Wagner, R White, A Wierzcholska, P Willmann, A Wörnlein, D Wouters, R Yang, V Zabalza, D Zaborov, M Zacharias, A A Zdziarski, A Zech, F Zefi, A Ziegler, N Żywucka
The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using γ-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant γ-ray signal above background...
September 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27622023/embracing-rejection-immunologic-trends-in-brain-metastasis
#8
REVIEW
S Harrison Farber, Vadim Tsvankin, Jessica L Narloch, Grace J Kim, April K S Salama, Gordana Vlahovic, Kimberly L Blackwell, John P Kirkpatrick, Peter E Fecci
Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood-brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of the CNS will be crucial to forging therapeutic advances...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27606778/pregnancy-outcomes-in-women-with-preeclampsia-superimposed-on-chronic-hypertension-with-and-without-severe-features
#9
Hind N Moussa, Mateo G Leon, Ana Marti, Alissar Chediak, Claudia Pedroza, Sean C Blackwell, Baha M Sibai
Objective The American Congress of Obstetricians and Gynecologists (ACOG) task force on hypertension in pregnancy introduced a new definition of superimposed preeclampsia (SIP) adding severe features (SF) as new criteria to define severe disease. They also recommended that those with SIP be delivered ≥ 37 weeks, whereas those with SF be delivered ≤ 34 weeks. Our aim was to investigate the validity of this new definition by comparing adverse pregnancy outcomes in SIP with (SIP-SF) and without SF (SIP)...
September 8, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27475758/bringing-together-pharmacological-and-psychological-approaches-to-mental-health-research
#10
Abigail Moss, H Valerie Curran, Michael A P Bloomfield, Sunjeev K Kamboj, Simon E Blackwell, Tom P Freeman
No abstract text is available yet for this article.
August 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27398621/the-genetic-architecture-of-type-2-diabetes
#11
Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stancáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Noël P Burtt, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C Florez, Laura J Scott, Andrew P Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I McCarthy
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups...
August 4, 2016: Nature
https://www.readbyqxmd.com/read/27364991/transglutaminase-is-a-critical-link-between-inflammation-and-hypertension
#12
Renna Luo, Chen Liu, Serra E Elliott, Wei Wang, Nicholas Parchim, Takayuki Iriyama, Patrick S Daugherty, Lijian Tao, Holger K Eltzschig, Sean C Blackwell, Baha M Sibai, Rodney E Kellems, Yang Xia
BACKGROUND: The pathogenesis of essential hypertension is multifactorial with different underlying mechanisms contributing to disease. We have recently shown that TNF superfamily member 14 LIGHT (an acronym for homologous to lymphotoxins, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes, also known as TNFSF14) induces hypertension when injected into mice. Research reported here was undertaken to examine the role of transglutaminase (TGase) in LIGHT-induced hypertension...
July 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27166393/tbcrc-010-phase-i-ii-study-of-dasatinib-in-combination-with-zoledronic-acid-for-the-treatment-of-breast-cancer-bone-metastasis
#13
Zahi Mitri, Rita Nanda, Kimberly Blackwell, Colleen M Costelloe, Ilona Hood, Caimiao Wei, Abenaa M Brewster, Nuhad K Ibrahim, Kimberly B Koenig, Gabriel N Hortobagyi, Catherine Van Poznak, Mothaffar F Rimawi, Stacy Moulder-Thompson
PURPOSE: Osteoclast-mediated bone resorption through src kinase releases growth factors, sustaining bone metastases. This trial determined the recommended phase II dose (RP2D) and clinical efficacy of the src kinase inhibitor dasatinib combined with zoledronic acid in bone predominant, HER2-negative breast cancer metastases. EXPERIMENTAL DESIGN: A 3+3 lead in phase I design confirmed the RP2D allowing activation of the single-arm, phase II trial. Zoledronic acid was administered intravenously on day 1, and dasatinib was given orally once daily for 28 days each cycle as twice daily administration caused dose-limiting toxicity (DLT)...
December 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27142695/an-evaluation-of-uk-foundation-trainee-doctors-learning-behaviours-in-a-technology-enhanced-learning-environment
#14
Hannah L Brooks, Sarah K Pontefract, James Hodson, Nicholas Blackwell, Elizabeth Hughes, John F Marriott, Jamie J Coleman
BACKGROUND: Technology-Enhanced Learning (TEL) can be used to educate Foundation Programme trainee (F1 and F2) doctors. Despite the advantages of TEL, learning behaviours may be exhibited that are not desired by system developers or educators. The aim of this evaluation was to investigate how learner behaviours (e.g. time spent on task) were affected by temporal (e.g. time of year), module (e.g. word count), and individual (e.g. knowledge) factors for 16 mandatory TEL modules related to prescribing and therapeutics...
2016: BMC Medical Education
https://www.readbyqxmd.com/read/27080434/a-cohort-of-indigenous-australian-women-and-their-children-through-pregnancy-and-beyond-the-gomeroi-gaaynggal-study
#15
A M Ashman, C E Collins, L Weatherall, L J Brown, M E Rollo, D Clausen, C C Blackwell, K G Pringle, J Attia, R Smith, E R Lumbers, K M Rae
Indigenous Australians have high rates of chronic diseases, the causes of which are complex and include social and environmental determinants. Early experiences in utero may also predispose to later-life disease development. The Gomeroi gaaynggal study was established to explore intrauterine origins of renal disease, diabetes and growth in order to inform the development of health programmes for Indigenous Australian women and children. Pregnant women are recruited from antenatal clinics in Tamworth, Newcastle and Walgett, New South Wales, Australia, by Indigenous research assistants...
August 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/26959208/pregnancy-associated-hypertension-in-glucose-intolerant-pregnancy-and-subsequent-metabolic-syndrome
#16
Madeline Murguia Rice, Mark B Landon, Michael W Varner, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Joseph R Biggio, John M Thorp, Edward K Chien, George Saade, Alan M Peaceman, Sean C Blackwell, J Peter VanDorsten
OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy...
April 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26945549/bruton-s-tyrosine-kinase-deficiency-inhibits-autoimmune-arthritis-in-mice-but-fails-to-block-immune-complex-mediated-inflammatory-arthritis
#17
Lindsay E Nyhoff, Bridgette L Barron, Elizabeth M Johnson, Rachel H Bonami, Damian Maseda, Benjamin A Fensterheim, Wei Han, Timothy S Blackwell, Leslie J Crofford, Peggy L Kendall
OBJECTIVE: Bruton's tyrosine kinase (BTK) is a B cell signaling protein that also contributes to innate immunity. BTK inhibitors prevent autoimmune arthritis but have off-target effects, and the mechanisms of protection remain unknown. We undertook these studies using genetic deletion to investigate the role of BTK in adaptive and innate immune responses that drive inflammatory arthritis. METHODS: BTK-deficient K/BxN mice were generated to study the role of BTK in a spontaneous model that requires both adaptive and innate immunity...
August 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26911395/a-holistic-approach-to-understanding-the-desorption-of-phosphorus-in-soils
#18
Daniel Menezes-Blackburn, Hao Zhang, Marc Stutter, Courtney D Giles, Tegan Darch, Timothy S George, Charles Shand, David Lumsdon, Martin Blackwell, Catherine Wearing, Patricia Cooper, Renate Wendler, Lawrie Brown, Philip M Haygarth
The mobility and resupply of inorganic phosphorus (P) from the solid phase were studied in 32 soils from the UK. The combined use of diffusive gradients in thin films (DGT), diffusive equilibration in thin films (DET) and the "DGT-induced fluxes in sediments" model (DIFS) were adapted to explore the basic principles of solid-to-solution P desorption kinetics in previously unattainable detail. On average across soil types, the response time (Tc) was 3.6 h, the desorption rate constant (k-1) was 0.0046 h(-1), and the desorption rate was 4...
April 5, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/26908710/increased-fiber-intake-decreases-premenopausal-breast-cancer-risk
#19
COMMENT
Kathleen K Harnden, Kimberly L Blackwell
No abstract text is available yet for this article.
March 2016: Pediatrics
https://www.readbyqxmd.com/read/26872784/traf2-exerts-opposing-effects-on-basal-and-tnf%C3%AE-induced-activation-of-the-classic-ikk-complex-in-hematopoietic-cells-in-mice
#20
Laiqun Zhang, Ken Blackwell, Lauren M Workman, Katherine N Gibson-Corley, Alicia K Olivier, Gail A Bishop, Hasem Habelhah
The role of TRAF2 and TRAF5 in TNFα-induced NF-κB activation has become complicated owing to the accumulation of conflicting data. Here, we report that 7-day-old TRAF2-knockout (KO) and TRAF2 TRAF5 double KO (TRAF2/5-DKO) mice exhibit enhanced canonical IκB kinase (IKK) and caspase-8 activation in spleen and liver, and that subsequent knockout of TNFα suppresses the basal activity of caspase-8, but not of IKK. In primary TRAF2 KO and TRAF2/5-DKO cells, TNFα-induced immediate IKK activation is impaired, whereas delayed IKK activation occurs normally; as such, owing to elevated basal and TNFα-induced delayed IKK activation, TNFα stimulation leads to significantly increased induction of a subset of NF-κB-dependent genes in these cells...
April 1, 2016: Journal of Cell Science
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