Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Anna K M Blackwell, Shadi Daryan, Deborah Roy, Daniel Duffy, Garrett Hisler, Katherine Sawyer, Ben Ainsworth, Derek Richards, Douglas Hiscock, Sophia Papadakis, Jamie Brown, Marcus R Munafò, Pamela Jacobsen, Paul Aveyard, Gemma Taylor
BACKGROUND: In the UK, smoking prevalence in people with depression (34%) and anxiety (29%) is more than double that of the general population (13%). People who stop smoking improve their mental health with comparable effect sizes found for antidepressants. In England, online psychological therapy is a standard treatment for depression and anxiety. Online therapy is an acceptable setting for smoking cessation support; however, integrated smoking and mental health support is not available...
April 19, 2024: Contemporary Clinical Trials
#2
JOURNAL ARTICLE
Sergey S Gutor, Bradley W Richmond, Vineet Agrawal, Evan L Brittain, Ciara M Shaver, Pingsheng Wu, Taryn K Boyle, Ravinder R Mallugari, Katrina Douglas, Robert N Piana, Joyce E Johnson, Robert F Miller, John H Newman, Timothy S Blackwell, Vasiliy V Polosukhin
Exertional dyspnea has been documented in U.S. military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We performed detailed histomorphometry of pulmonary vasculature in 52 Veterans with biopsy-proven post-deployment respiratory syndrome (PDRS) and then recruited five of these same Veterans with continued exertional dyspnea to undergo a follow-up clinical evaluation, including symptom questionnaire, pulmonary function testing, surface echocardiography, and right heart catheterization (RHC)...
April 9, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
#3
JOURNAL ARTICLE
Ayodeji Adegunsoye, Jonathan A Kropski, Juergen Behr, Timothy S Blackwell, Tamera J Corte, Vincent Cottin, Allan Glanville, Marilyn K Glassberg, Matthias Griese, Gary M Hunninghake, Kerri A Johannson, Michael P Keane, John S Kim, Martin Kolb, Toby M Maher, Justin M Oldham, Anna J Podolanczuk, Ivan O Rosas, Fernando J Martinez, Imre Noth, David A Schwartz
Recent genetic and genomic advancements have elucidated the complex etiology of idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases (ILDs), emphasizing the contribution of heritable factors. This state-of-the-art review synthesizes evidence on significant genetic contributors to pulmonary fibrosis (PF), including rare genetic variants and common single nucleotide polymorphisms (SNPs). The MUC5B promoter variant is unusual, a common SNP that markedly elevates the risk of early and established PF...
April 4, 2024: American Journal of Respiratory and Critical Care Medicine
#4
JOURNAL ARTICLE
Ingrid Pretzer-Aboff, R K Elswick, Arnaud Gouelle, Noah Helm, GinaMari Blackwell, Leslie Cloud
INTRODUCTION: Most people with Parkinson's disease (PD) will experience gait problems. Previous studies demonstrated improved gait and balance after vibration stimulation was applied to the feet of PD patients. However, not all study participants showed improvement, perhaps due to sub-optimal vibration stimulus. Thus far, the optimal frequency and amplitude of vibration for mitigating gait dysfunction in PD have yet to be systematically explored. This study aimed to deliver vibration to the feet of 26 people with PD gait disturbances...
2024: Clinical parkinsonism & related disorders
#5
JOURNAL ARTICLE
Heini M Natri, Christina B Del Azodi, Lance Peter, Chase J Taylor, Sagrika Chugh, Robert Kendle, Mei-I Chung, David K Flaherty, Brittany K Matlock, Carla L Calvi, Timothy S Blackwell, Lorraine B Ware, Matthew Bacchetta, Rajat Walia, Ciara M Shaver, Jonathan A Kropski, Davis J McCarthy, Nicholas E Banovich
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the mechanisms through which genetic variation influences complex traits and disease pathobiology. To this end, we performed single-cell RNA sequencing of lung tissue from 66 individuals with pulmonary fibrosis and 48 unaffected donors. Using a pseudobulk approach, we mapped expression quantitative trait loci (eQTLs) across 38 cell types, observing both shared and cell-type-specific regulatory effects...
March 28, 2024: Nature Genetics
#6
JOURNAL ARTICLE
Xueying Zhang, Courtney K Blackwell, Janet Moore, Shelley H Liu, Chang Liu, Christopher B Forrest, Jody Ganiban, Annemarie Stroustrup, Judy L Aschner, Leonardo Trasande, SeanC L Deoni, Amy J Elliott, Jyoti Angal, Catherine J Karr, Barry M Lester, Cindy T McEvoy, T Michael O'Shea, Rebecca C Fry, Gayle M Shipp, James E Gern, Julie Herbstman, Kecia N Carroll, Susan L Teitelbaum, Robert O Wright, Rosalind J Wright
The corona virus disease (COVID-19) pandemic disrupted daily life worldwide, and its impact on child well-being remains a major concern. Neighborhood characteristics affect child well-being, but how these associations were affected by the pandemic is not well understood. We analyzed data from 1039 children enrolled in the Environmental influences on Child Health Outcomes Program whose well-being was assessed using the Patient-Reported Outcomes Measurement Information System Global Health questionnaire and linked these data to American Community Survey (ACS) data to evaluate the impacts of neighborhood characteristics on child well-being before and during the pandemic...
March 26, 2024: Environmental Research
#7
JOURNAL ARTICLE
Sigmund J Degitz, Philip P Degoey, Jonathan T Haselman, Jennifer H Olker, Emma H Stacy, Chad Blanksma, Scott Meyer, Kali Z Mattingly, Brett Blackwell, Anne S Opseth, Michael W Hornung
As part of the US Environmental Protection Agency's perfluoroalkyl and polyfluoroalkyl substances (PFAS) Action Plan, the agency is committed to increasing our understanding of the potential ecological effects of PFAS. The objective of these studies was to examine the developmental toxicity of PFAS using the laboratory model amphibian species Xenopus laevis. We had two primary aims: (1) to understand the developmental toxicity of a structurally diverse set of PFAS compounds in developing embryos and (2) to characterize the potential impacts of perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), and hexafluoropropylene oxide-dimer acid (HFPO-DA a...
March 26, 2024: Journal of Applied Toxicology: JAT
#8
JOURNAL ARTICLE
Maddy L Dyer, Steph F Suddell, Jasmine N Khouja, Michelle A Havill, Anna K M Blackwell, Olivia M Maynard, Marcus R Munafò, Angela S Attwood
INTRODUCTION: Youth use of electronic cigarettes (e-cigarettes) is rising globally and is associated with health harms. Flavour descriptions on e-liquid packaging may contribute to the appeal of e-cigarettes among youth. This study compared subjective ratings of e-liquid packaging flavour descriptions among non-smoking and non-vaping UK adolescents. METHODS: This was an online observational study in a UK sample of non-smoking and non-vaping adolescents aged 11-17 years...
March 12, 2024: Nicotine & Tobacco Research
#9
JOURNAL ARTICLE
Sharoda Dasgupta, Stacy M Crim, John K Weiser, Angela Blackwell, Jen-Feng Lu, Margaret A Lampe, Ada Dieke, Robyn Neblett Fanfair
INTRODUCTION: The sexual and reproductive health of cisgender women with HIV is essential for overall health and well-being. Nationally representative estimates of sexual and reproductive health outcomes among women with HIV were assessed in this study. METHODS: Data from the Centers for Disease Control and Prevention's Medical Monitoring Project-including data on sexual and reproductive health-were collected during June 2018-May 2021 through interviews and medical record abstraction among women with HIV and analyzed in 2023...
February 27, 2024: American Journal of Preventive Medicine
#10
JOURNAL ARTICLE
Matthew B Murphy, Zhenjiang Yang, Tuerdi Subati, Eric Farber-Eger, Kyungsoo Kim, Daniel J Blackwell, Matthew R Fleming, Joshua M Stark, Joseph C Van Amburg, Kaylen K Woodall, Justin P Van Beusecum, Vineet Agrawal, Charles D Smart, Ashley Pitzer, James B Atkinson, Agnes B Fogo, Julie A Bastarache, Annet Kirabo, Quinn S Wells, Meena S Madhur, Joey V Barnett, Katherine T Murray
AIMS: The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signaling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and hematologic disorders including stroke. In mice, deletion of Lnk causes inflammation and oxidative stress. We hypothesized that Lnk-/- mice are susceptible to atrial fibrillation (AF) and that rs3184504 is associated with AF and AF-related stroke in humans. During inflammation, reactive lipid dicarbonyls are a major component of oxidative injury, and we further hypothesized that these mediators are critical drivers of the AF substrate in Lnk-/- mice...
February 20, 2024: Cardiovascular Research
#11
JOURNAL ARTICLE
Runguo Wu, Claire Williams, Junwen Zhou, Iryna Schlackow, Jonathan Emberson, Christina Reith, Anthony Keech, John Robson, Jane Armitage, Alastair Gray, John Simes, Colin Baigent, Borislava Mihaylova, Jane Armitage, Colin Baigent, Elizabeth Barnes, Lisa Blackwell, Rory Collins, Kelly Davies, Jonathan Emberson, Jordan Fulcher, Heather Halls, William G Herrington, Lisa Holland, Anthony Keech, Adrienne Kirby, Borislava Mihaylova, Rachel O'Connell, David Preiss, Christina Reith, John Simes, Kate Wilson, Michael Blazing, Eugene Braunwald, James de Lemos, Sabina Murphy, Terje R Pedersen, Marc Pfeffer, Harvey White, Stephen Wiviott, Michael Clearfield, John R Downs, Antonio Gotto, Stephen Weis, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Terje R Pedersen, David Gordon, Barry Davis, Curt Furberg, Richard Grimm, Sara Pressel, Jeffrey L Probstfield, Mahboob Rahman, Lara Simpson, Michael Koren, Björn Dahlöf, Ajay Gupta, Neil Poulter, Peter Sever, Hans Wedel, Robert H Knopp, Stuart Cobbe, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Roland Schmieder, Faiez Zannad, D John Betteridge, Helen M Colhoun, Paul N Durrington, John Fuller, Graham A Hitman, Andrew Neil, Eugene Braunwald, Barry Davis, C Morton Hawkins, Lemuel Moyé, Marc Pfeffer, Frank Sacks, John Kjekshus, Hans Wedel, John Wikstrand, Christoph Wanner, Vera Krane, Maria Grazia Franzosi, Roberto Latini, Donata Lucci, Aldo Maggioni, Roberto Marchioli, Enrico B Nicolis, Luigi Tavazzi, Gianni Tognoni, Jackie Bosch, Eva Lonn, Salim Yusuf, Jane Armitage, Louise Bowman, Rory Collins, Anthony Keech, Martin Landray, Sarah Parish, Richard Peto, Peter Sleight, John Jp Kastelein, Terje R Pedersen, Robert Glynn, Antonio Gotto, John Jp Kastelein, Wolfgang Koenig, Jean MacFadyen, Paul M Ridker, Anthony Keech, Stephen MacMahon, Ian Marschner, Andrew Tonkin, John Shaw, John Simes, Harvey White, Patrick W Serruys, Genell Knatterud, Gerard J Blauw, Stuart Cobbe, Ian Ford, Peter Macfarlane, Chris Packard, Naveed Sattar, James Shepherd, Stella Trompet, Eugene Braunwald, Christopher P Cannon, Sabina Murphy, Rory Collins, Jane Armitage, Louise Bowman, Richard Bulbulia, Richard Haynes, Sarah Parish, Richard Peto, Peter Sleight, Pierre Amarenco, K Michael Welch, John Kjekshus, Terje R Pedersen, Lars Wilhelmsen, Philip Barter, Antonio Gotto, John LaRosa, John Jp Kastelein, James Shepherd, Stuart Cobbe, Ian Ford, Sharon Kean, Peter Macfarlane, Chris Packard, Michele Roberston, Naveed Sattar, James Shepherd, Robin Young, Hiroyuki Arashi, Robert Clarke, Marcus Flather, Shinya Goto, Uri Goldbourt, Jemma Hopewell, G Kees Hovingh, George Kitas, Connie Newman, Marc S Sabatine, Gregory G Schwartz, Liam Smeeth, Jonathan Tobert, John Varigos, Junichi Yamamguchi
BACKGROUND: UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. AIM: To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK. DESIGN AND SETTING: A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys...
February 19, 2024: British Journal of General Practice
#12
JOURNAL ARTICLE
Heeju Ryu, Timothy M Bi, Thomas H Pulliam, Korok Sarkar, Candice D Church, Nandita Kumar, Koshlan Mayer-Blackwell, Saumya Jani, Nirasha Ramchurren, Ulla K Hansen, Sine R Hadrup, Steven P Fling, David M Koelle, Paul Nghiem, Evan W Newell
Merkel cell carcinoma is a skin cancer often driven by Merkel cell polyomavirus (MCPyV) with high rates of response to anti-PD-1 therapy despite low mutational burden. MCPyV-specific CD8 T cells are implicated in anti-PD-1-associated immune responses and provide a means to directly study tumor-specific T cell responses to treatment. Using mass cytometry and combinatorial tetramer staining, we find that baseline frequencies of blood MCPyV-specific cells correlated with response and survival. Frequencies of these cells decrease markedly during response to therapy...
January 30, 2024: Cell reports medicine
#13
JOURNAL ARTICLE
Stefany Olague, Helen Boyle, Imtiaz Ahmed, Basharat Buchh, Giang Sinh T Truong, Brent Reyburn, Clarissa DeLeon, Grace C Lin, Kaashif A Ahmad, Barbara Carr, Meghali Singhal, Melissa Althouse, Raymond Castro, Anthony Rudine, Evelyn Rider, Melissa L Macomber-Estill, Bradley Doles, Jenelle F Ferry, Hector Pierantoni, Savannah Sutherland, Reese H Clark, Courtney K Blackwell, P Brian Smith, Daniel K Benjamin, Rachel G Greenberg
Under traditional circumstances, most clinical trials rely on in-person operations to identify, recruit, and enroll study participants and to complete study-related visits. During unusual circumstances, such as the COVID-19 pandemic, the typical clinical trial model is challenged and forced to explore alternative approaches to implementing study recruitment, participant enrollment, and data collection strategies. One such alternative is a direct-to-participant approach which leverages electronic resources and relevant technological devices ( e...
April 2024: Contemporary Clinical Trials Communications
#14
JOURNAL ARTICLE
Maxwell Mansolf, Courtney K Blackwell, David Cella, Jin-Shei Lai
PURPOSE: Using the lens of classical test theory, we examine a linkage's generalizability with respect to use in multivariable analyses, including multiple regression and structural equation modeling, rather than comparison of established subpopulations as is most common in the literature. METHODS: To aid in this evaluation, we present a structural-equation-modeling based statistical method to examine the suitability of a given linkage for use cases involving continuous and categorical variables external to the linkage itself...
January 31, 2024: Quality of Life Research
#15
JOURNAL ARTICLE
Caroline Bull, Emma Hazelwood, Joshua A Bell, Vanessa Tan, Andrei-Emil Constantinescu, Carolina Borges, Danny Legge, Kimberley Burrows, Jeroen R Huyghe, Hermann Brenner, Sergi Castellvi-Bel, Andrew T Chan, Sun-Seog Kweon, Loic Le Marchand, Li Li, Iona Cheng, Rish K Pai, Jane C Figueiredo, Neil Murphy, Marc J Gunter, Nicholas J Timpson, Emma E Vincent
BACKGROUND: Recognizing the early signs of cancer risk is vital for informing prevention, early detection, and survival. METHODS: To investigate whether changes in circulating metabolites characterize the early stages of colorectal cancer (CRC) development, we examined the associations between a genetic risk score (GRS) associated with CRC liability (72 single-nucleotide polymorphisms) and 231 circulating metabolites measured by nuclear magnetic resonance spectroscopy in the Avon Longitudinal Study of Parents and Children (N = 6221)...
December 21, 2023: ELife
#16
JOURNAL ARTICLE
Ryan D Blackwell, Stephen Parlamas, Nicholas J Dunbar, Sabir K Ismaily, David Rodriguez-Quintana, Alfred A Mansour, Shuyang Han
BACKGROUND: Pelvic tilt is an important sagittal parameter that varies greatly among individuals. The objective of this study was to quantify the effect of pelvic tilt on femoral head coverage and range of motion in a dysplastic population following periacetabular osteotomy. METHODS: Twenty-three dysplastic hips from 19 patients (17 female, 2 male) were included in this study. Three-dimensional models were reconstructed using pre-operative CT images, and patient-specific neutral pelvic tilt was obtained on an anteroposterior X-ray...
December 9, 2023: Clinical Biomechanics
#17
JOURNAL ARTICLE
Aaron Domack, Morgan M Sandelski, Syed Ali, Keith E Blackwell, Marisa Buchakjian, Andrés M Bur, Steven B Cannady, Carlos X Castellanos, Yadranko Ducic, Tamer A Ghanem, Andrew T Huang, Ryan S Jackson, Niels Kokot, Shawn Li, Patrik Pipkorn, Sidharth V Puram, Rod Rezaee, Karthik Rajasekaran, Yelizaveta Shnayder, Uttam K Sinha, Daniel Sukato, Neeraj Suresh, Akina Tamaki, Carissa M Thomas, Eric J Thorpe, Mark K Wax, Sara Yang, Andrea Ziegler, Amy L Pittman
INTRODUCTION: Coronavirus disease 2019 (COVID-19) affects the vascular system, subjecting patients to a hypercoagulable state. This is of particular concern for the success of microvascular free flap reconstruction. This study aims to report head and neck free flap complications in patients with COVID-19 during the perioperative period. We believe these patients are more likely to experience flap complications given the hypercoagulable state. METHODS: This is a multi-institutional retrospective case series of patients infected with COVID-19 during the perioperative period for head and neck free flap reconstruction from March 2020 to January 2022...
November 8, 2023: Laryngoscope
#18
JOURNAL ARTICLE
Vineet Agrawal, Jonathan A Kropski, Jason J Gokey, Elizabeth Kobeck, Matthew B Murphy, Katherine T Murray, Niki L Fortune, Christy S Moore, David F Meoli, Ken Monahan, Yan Ru Su, Thomas Blackwell, Deepak K Gupta, Megha H Talati, Santhi Gladson, Erica J Carrier, James D West, Anna R Hemnes
BACKGROUND: Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood. We sought to determine whether a well-accepted murine model of HFpEF also displays features of PH, and we sought to identify pathways that might drive early remodeling of the pulmonary vasculature in HFpEF. METHODS: Eight-week-old male and female C57BL/6J mice received either Nγ -nitro-L-arginine methyl ester and high-fat diet or control water and diet for 2, 5, and 12 weeks...
November 10, 2023: Circulation Research
#19
JOURNAL ARTICLE
Karen L Thierry, Christine W Hockett, Amy J Elliott, Adaeze C Wosu, Aruna Chandran, Courtney K Blackwell, Amy E Margolis, Margaret R Karagas, Carmen Velez Vega, Cristiane S Duarte, Carlos A Camargo, Barry M Lester, Elisabeth C McGowan, Assiamira Ferrara, Thomas G O'Connor, Cindy T McEvoy, Alison E Hipwell, Leslie D Leve, Jody M Ganiban, Sarah S Comstock, Dana Dabelea
BACKGROUND: Economic hardships imposed by the pandemic could have implications for children's experiences of adversity in the home, or Adverse Childhood Experiences (ACEs). OBJECTIVE: This observational cohort study examined associations between COVID-19-related hardships and distress (e.g., job loss, caregiver stress) and the cumulative number of child ACEs reported by caregivers during the pandemic (i.e., March 1, 2020-February 28, 2022). PARTICIPANTS AND SETTING: The study included children (N = 4345; median age = 6...
November 1, 2023: Child Abuse & Neglect
#20
JOURNAL ARTICLE
Courtney K Blackwell, Phillip Sherlock, Kathryn L Jackson, Julie A Hofheimer, David Cella, Molly A Algermissen, Akram N Alshawabkeh, Lyndsay A Avalos, Tracy Bastain, Clancy Blair, Michelle Bosquet Enlow, Patricia A Brennan, Carrie Breton, Nicole R Bush, Aruna Chandran, Shaina Collazo, Elisabeth Conradt, Sheila E Crowell, Sean Deoni, Amy J Elliott, Jean A Frazier, Jody M Ganiban, Diane R Gold, Julie B Herbstman, Christine Joseph, Margaret R Karagas, Barry Lester, Jessica A Lasky-Su, Leslie D Leve, Kaja Z LeWinn, W Alex Mason, Elisabeth C McGowan, Kimberly S McKee, Rachel L Miller, Jenae M Neiderhiser, Thomas G O'Connor, Emily Oken, T Michael O'Shea, David Pagliaccio, Rebecca J Schmidt, Anne Marie Singh, Joseph B Stanford, Leonardo Trasande, Rosalind J Wright, Cristiane S Duarte, Amy E Margolis
To assess the public health impact of the COVID-19 pandemic on mental health, investigators from the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) research program developed the Pandemic-Related Traumatic Stress Scale (PTSS). Based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) acute stress disorder symptom criteria, the PTSS is designed for adolescent (13-21 years) and adult self-report and caregiver-report on 3-12-year-olds. To evaluate psychometric properties, we used PTSS data collected between April 2020 and August 2021 from non-pregnant adult caregivers ( n = 11,483), pregnant/postpartum individuals ( n = 1,656), adolescents ( n = 1,795), and caregivers reporting on 3-12-year-olds ( n = 2,896)...
November 2023: Psychological Assessment
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
